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WO1988007080A3 - Transgenic animal cells resistant to viral infection - Google Patents

Transgenic animal cells resistant to viral infection Download PDF

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Publication number
WO1988007080A3
WO1988007080A3 PCT/US1988/000491 US8800491W WO8807080A3 WO 1988007080 A3 WO1988007080 A3 WO 1988007080A3 US 8800491 W US8800491 W US 8800491W WO 8807080 A3 WO8807080 A3 WO 8807080A3
Authority
WO
WIPO (PCT)
Prior art keywords
animal cells
viral infection
transgenic animal
cells resistant
resistant
Prior art date
Application number
PCT/US1988/000491
Other languages
French (fr)
Other versions
WO1988007080A2 (en
Inventor
Erik A Petrovskis
Leonard E Post
Original Assignee
Upjohn Co
Erik A Petrovskis
Leonard E Post
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Erik A Petrovskis, Leonard E Post filed Critical Upjohn Co
Publication of WO1988007080A2 publication Critical patent/WO1988007080A2/en
Publication of WO1988007080A3 publication Critical patent/WO1988007080A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention provides methods for producing animal cells resistant to viral infection. In particular, the present invention provides animal cells transformed with the pseudorabies virus gene encoding glycoprotein gp50 which are resistant to infection by herpes viruses, specifically, herpes simplex virus and pseudorabies virus.
PCT/US1988/000491 1987-03-09 1988-02-26 Transgenic animal cells resistant to viral infection WO1988007080A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2340187A 1987-03-09 1987-03-09
US023,401 1987-03-09

Publications (2)

Publication Number Publication Date
WO1988007080A2 WO1988007080A2 (en) 1988-09-22
WO1988007080A3 true WO1988007080A3 (en) 1988-11-03

Family

ID=21814864

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/000491 WO1988007080A2 (en) 1987-03-09 1988-02-26 Transgenic animal cells resistant to viral infection

Country Status (4)

Country Link
EP (1) EP0354213A1 (en)
JP (1) JPH02502425A (en)
AU (1) AU616211B2 (en)
WO (1) WO1988007080A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989005349A1 (en) * 1987-12-09 1989-06-15 The Australian National University Method of combating viral infections
NL8901651A (en) * 1989-06-29 1991-01-16 Centraal Diergeneeskundig Inst VACCINE AGAINST PESTIVIRUS INFECTIONS, SUCH AS SWINE FEVER; USEFUL NUCLEOTIDE SEQUENCES AND POLYPEPTIDES THEREFOR.
FR2655855B1 (en) * 1989-12-20 1992-04-10 Pasteur Institut GENETIC PROTECTION OF ANIMALS AGAINST INFECTION WITH THE BOVINE LEUCEMOGEN VIRUS, AND PROVIRUS AND RECOMBINANT VIRUS DERIVED FROM THIS VIRUS.
GB9520641D0 (en) * 1995-10-10 1995-12-13 Medical Res Council Improvements in or relating to protection against intracellular infection
IL123411A0 (en) * 1998-02-22 1998-09-24 Kimron Veterinary Inst High efficiency methods and compositions for integrating exogenous dna into genomic dna of sperm

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986005516A1 (en) * 1985-03-21 1986-09-25 Duke University Parasite-derived resistance
WO1987002058A1 (en) * 1985-10-04 1987-04-09 The Upjohn Company Pseudorabies virus protein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE122720T1 (en) * 1987-03-19 1995-06-15 Synergen Inc VIRAL VECTOR SYSTEM FOR INTRODUCING FOREIGN DNA EXPRESSION PRODUCTS IN GALLINACEOUS BIRDS.
EP0364492A1 (en) * 1987-06-30 1990-04-25 The Upjohn Company Virus proteins having reduced o-linked glycosylation
ZA886518B (en) * 1987-09-03 1989-05-30 Commw Scient Ind Res Org Coal ash modification and reduction

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986005516A1 (en) * 1985-03-21 1986-09-25 Duke University Parasite-derived resistance
WO1987002058A1 (en) * 1985-10-04 1987-04-09 The Upjohn Company Pseudorabies virus protein

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Cell, vol. 27, November 1981 R.L. Brinster et al.: "Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs" pages 223-231 *
Journal of Virology, vol. 59, no. 2, August 1986, American Soc. for Microbiology, US; E.A. Petrovskis et al.: "DNA sequence of the gene for Pseudorabies virus gp50, a glycoprotein without N-linked glycosylation", pages 216-223 *
Science, vol. 229, 26th July 1985 J.G. Izant et al.: "Constitutive and conditional suppression of exogenous and endogenous genes by anti-sense RNA" pages 345-352 *

Also Published As

Publication number Publication date
WO1988007080A2 (en) 1988-09-22
JPH02502425A (en) 1990-08-09
AU616211B2 (en) 1991-10-24
AU2380088A (en) 1988-10-10
EP0354213A1 (en) 1990-02-14

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