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WO1983000386A1 - Conteneur pour petites quantites de liquides - Google Patents

Conteneur pour petites quantites de liquides Download PDF

Info

Publication number
WO1983000386A1
WO1983000386A1 PCT/US1982/000980 US8200980W WO8300386A1 WO 1983000386 A1 WO1983000386 A1 WO 1983000386A1 US 8200980 W US8200980 W US 8200980W WO 8300386 A1 WO8300386 A1 WO 8300386A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
housing
receptacle
cavity
inches
Prior art date
Application number
PCT/US1982/000980
Other languages
English (en)
Inventor
Hospital Supply Corporation American
Max D. Liston
Paul K. Hsei
Original Assignee
American Hospital Supply Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Hospital Supply Corp filed Critical American Hospital Supply Corp
Priority to AU88235/82A priority Critical patent/AU8823582A/en
Publication of WO1983000386A1 publication Critical patent/WO1983000386A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/023—Adapting objects or devices to another adapted for different sizes of tubes, tips or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0854—Double walls

Definitions

  • Biofluids are routinely analyzed in hospital clinical laboratories to aid in the diagnosis of disease and to provide critical information about a patient's well-being.
  • the constituents of blood, lymph, urine, or products derived therefrom provide meaningful patient health information to a clinician or physician. Since physicians are becoming increasingly dependent on clinical
  • the processing and manipulation steps generally include the eentrifugation of blood or filtration of biological fluids followed by serial dilutions and tr ⁇ insf er to a cuvette or sample container.
  • Biological fluids such -as blood
  • Conventional blood collection tubes used in many hospitals and clinics are elongated cylindrical containers having an opening at one
  • ⁇ end fitted with a resilient stopper, and a rounded or flat bottom at the other end.
  • the most common size of these blood collection tubes accommodates 30 10 milliliters of blood or other biological fluid.
  • Illustrative of such blood collection tubes is the VACUTAINER* brand sold by Becton-Diekinson ( ⁇ Reg ⁇ istered Trademark of Becton-Diekinson).
  • a phlembotomist first obt-ains a specimen of a patient's blood, appropriately labels the patient's specimen, and delivers the specimen to the clinical laboratory for analysis. The plasma or serum derived therefrom is processed and analyzed either manually, sem ⁇ - automat ⁇ cally, or automatically. In the majority of cases, the specimen must first be dispensed from the collection tube to a sample test tube or cuvette as described above.
  • Certain automated chemical analyzers are capable of utilizing standard- sized conventional specimen containers as a means for introducing a patient's specimen into the analyzer.
  • they are not equipped to handle specimen containers designed to hold small quantities of fluid. Therefore, one such instrument manufacturer requires that a separate sample cup be placed in the top of a standard-sized 10 milliliter collection tube for withdrawal of specimen and delivery to the analyzer.
  • This creates several drawbacks for the rapid and reliable processing of a patient's specimen.
  • One problem being the additional error-prone and time-consuming step of transferring the specimen from the specimen container to the sample cup, and another being the size requirements of the sample cups which contributes to significant evaporation of smaller fluid samples and which do not permit handling of small or micro quantities of fluid sample. Arrangements such as this are also prone to sample spillage due to dislodge ments of the sample cup from the top of the container.
  • a container for holding a small quantity of liquid comprising an elongated housing having top and bottom end portions; and a fluid receptacle disposed at said top portion formed integral with said housing, the dimensions of said receptacle being substantially less than the dimensions of said housing.
  • Figure 1 is a side plan view of a standard-sized sample container con ⁇ structed in accordance with the prior art
  • Figure 2 is a side plan view of a container for small quantities of liquids constructed in accordance with an embodiment of the present invention
  • Figure 3 is a partial, side sectional view of the container shown in ⁇ Figure 2 taken along line 3-3 thereof;
  • Figure 4 is a top view of the container shown in Figure 2;
  • Figure 5 is a side plan view of an alternate embodiment of a container for small quantities of liquids constructed in accordance with the present invention.
  • Figure 6 is a partial, side sectional view of the container shown in
  • Figure 7 is a top view of the container shown in Figure 5; Detailed Description of the Preferred Embodiment
  • a micro-container has been developed in accordance with the present invention which overcomes the above-described problems associated with known containers designed for holding small sample volumes.
  • the micro- container of the present invention is not only useful for storage of biological fluids in conventional test tube storage racks, but is also useful in storage racks especially designed for use in automated chemical analyzers since their overall dimensions are similar to those of standard blood collection tubes.
  • the micro-containers of the present invention are easily handled by a laboratory technician, resulting in a rapid and reliable processing of fluid specimens for analysis.
  • the preferred containers are cylindrical.
  • the preferred micro-container of the present invention comprises an elongated cylindrical housing 10 having a top 12 and bottom 14 end portion and general dimensions similar to the standard sample collection tube 15 shown in Figure 1.
  • the clinician is .able to conveniently grasp the micro-container by its elongated housing portion 10 as he or she would a conventional container.
  • the elongated housing also provides an adequate area for positioning of labels or other means of identification . on the container to facilitate positive sample identification in an automated clinical analyzer.
  • the elongated cylindrical housing acts as a permanent support for the micro-container such that tipping of the container and subsequent spillage of precious sample is avoided.
  • the receptacle 18 Disposed at the top end portion 12 of the elongated cylindrical housing 10 is a fluid receptacle 18, for holding small quantities of liquid.
  • the receptacle 18 comprises and open-topped enclosure member 20 projecting upwardly from the top 12 of the housing 10.
  • the receptacle includes an upstanding cylindrical wall portion 22 extending from the top 12 of said housing 10, and a curved, preferably concave bottom portion 24 adjacent
  • enclosure member 20 has an inner volume of approximately 0.6 cubic centimeters to approximately 1.2 cubic centimeters.
  • the wall portion 22 of enclosure member 20 is preferably high enough to contain small amounts of sample at the bottom-most portion thereof and still have enough head space to avoid spillage or evaportion of said sample. In one use of the present invention, this head space is also necessary for determining the meniscus level of the fluid contained therein.
  • the liquid volume size of enclosure member 20 will be less than 1 milliliter.
  • the fluid receptacle 18 comprises a cavity 26 formed within and integral with the top end 12 of the cylindrical housing 10.
  • the cavity 26 includes a cylindrical wall portion 28 depending downwardly into the housing 10 and extending from a horizontal top wall portion 30 of said housing, and a curved, preferably concave bottom portion 32 adjacent to and integral with the bottom of portion of said cylindrical cavity.
  • the dimensions of the cavity are substantially less than the dimensions of said housing and preferably the cross-sectional area of the cavity is substantially smaller than that of the housing.
  • the depth of the cavity walls 28 can be increased substantially more than the height of the wall portion 22 of enclosure member 20 of the alternate embodiment described above since the overall height of the container need not be changed.
  • An additional advantage of the embodiment in Figures 5 and 6 of present invention is that the shoulder region 34 between the receptacle and housing as shown in Figures 2 and 3 is eliminated. Although this would not affect the use of the containers in most procedures, it has been found that the embodiment shown in Figures 5 and 6 is more ideally suited for use in automated chemical analyzers such as described in co-pending application Serial Number , filed July , 1981.
  • a level-sensing device is disclosed which controls the elevation of the liquid level 36 in the sample containers to a predetermined height. The elevation of the containers to this predetermined height facilitates the dispensing of the sample from the container to the cuvettes in the chemical analyzer.
  • the micro-container shown in Figures 2-4 has an additional interface or shoulder 34 between the open-topped enclosure 20 and the cylindrical housing 10 which may produce a false signal by deflecting the path of the light beam to the optical means.
  • This potential problem can been eliminated with the use of the micro-container shown in Figures 5-7 since this additional interface or shoulder 35 is eliminated.
  • this shoulder may also interf er with the mechanical handling of the micro-container by the automated instru ⁇ ment.
  • the micro-containers of the present invention may be formed by injection molding of polystyrene or other suitable plastics, although other non-plastic materials are also suitable for forming the micro- containers.
  • the container of one embodiment of the present invention must be capable of transmitting light, and preferably has a polished upper portion 40 so as to efficiently transmit light without scattering thereof.
  • the overall dimensions of the micro-container permit it to be used in auto- mated clinical analyzers which are designed to employ conventional blood . - collection tubes, and the smaller cross-sectional dimension of the receptacle prevents evaporation of fluid due to currents of air passing thereover.
  • the receptacle should preferably have su ficient depth to minimize the con ⁇ vention of air, and in keeping with the micro-sample requirements, the diameter of the receptacle should be substantially smaller than that of the housing to insure an adequate fluid height for dispensing of specimen therefrom.
  • the overall diameter of housing 10 is about 0.625 inches, and it has a height of about 4.0 inches.
  • the horizontal wall portion 30 of the housing has a length of 0.188 inches, and the corresponding diameter of fluid receptacle 18 is about 0.250 inches.
  • the length of the downwardly depending cylindrical wall portion 28 of the cavity is about 1.3 inches.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

Le conteneur comprend un boîtier allongé (10) contenant un réceptacle de fluide (18) disposé dans l'extrémité supérieure (12) du boîtier. Les dimensions du réceptacle sont sensiblement inférieures aux dimensions totales du boîtier (10), ce qui facilite la manipulation du conteneur et empêche l'évaporation du liquide contenu.
PCT/US1982/000980 1981-07-20 1982-07-19 Conteneur pour petites quantites de liquides WO1983000386A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU88235/82A AU8823582A (en) 1981-07-20 1982-07-19 Container for small quantities of liquids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28498081A 1981-07-20 1981-07-20
US284,980810720 1981-07-20

Publications (1)

Publication Number Publication Date
WO1983000386A1 true WO1983000386A1 (fr) 1983-02-03

Family

ID=23092261

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1982/000980 WO1983000386A1 (fr) 1981-07-20 1982-07-19 Conteneur pour petites quantites de liquides

Country Status (4)

Country Link
EP (1) EP0084557A4 (fr)
JP (1) JPS58501146A (fr)
ES (1) ES275137Y (fr)
WO (1) WO1983000386A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252623A3 (en) * 1986-07-10 1988-11-17 Technicon Instruments Corporation Microsample cup for liquid analysis systems microsample cup for liquid analysis systems
WO1990000442A1 (fr) * 1988-07-07 1990-01-25 Walter Sarstedt Geräte und Verbrauchsmaterial für Medizin und Wissenschaft Reacteur pour quantites minimes d'echantillons fluides
EP0434147A3 (en) * 1989-12-22 1991-10-09 Eastman Kodak Company Kit of collection vessels of uniform outside dimensions, different volumes
FR2688888A1 (fr) * 1992-03-23 1993-09-24 Boy Sa Inst Jacques Dispositif destine notamment a la mise en óoeuvre de microtechniques d'analyse.
EP0819941A3 (fr) * 1991-03-04 1998-11-18 Ciba Corning Diagnostics Corp. Conteneur pour réactif avec convercle
US6436349B1 (en) 1991-03-04 2002-08-20 Bayer Corporation Fluid handling apparatus for an automated analyzer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2302830A (en) * 1940-10-30 1942-11-24 Sol A Axelrad Microscope test slide
US3807955A (en) * 1971-04-15 1974-04-30 Becton Dickinson Co Serum/plasma isolator cup
US3942717A (en) * 1973-02-09 1976-03-09 Robison William O Specimen container
US4015941A (en) * 1975-01-29 1977-04-05 Japan Medical Supply Co., Ltd. Test tube assembly
US4021124A (en) * 1975-02-27 1977-05-03 Kunststoff-Spritzgusswerk Vessels for the optical observation of liquids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2252750A (en) * 1938-08-08 1941-08-19 Walter M Basch Transparent double walled jar for testing liquids
DE1299136B (de) * 1965-03-25 1969-07-10 Hellma Gmbh & Co Glastechnisch Kuevette mit Temperiermantel, insbesondere solche Fluessigkeitskuevette
US3811326A (en) * 1972-02-10 1974-05-21 V Sokol Disposable dilution system
US4172670A (en) * 1977-06-27 1979-10-30 Welker Robert H Liquid sample collection apparatus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2302830A (en) * 1940-10-30 1942-11-24 Sol A Axelrad Microscope test slide
US3807955A (en) * 1971-04-15 1974-04-30 Becton Dickinson Co Serum/plasma isolator cup
US3942717A (en) * 1973-02-09 1976-03-09 Robison William O Specimen container
US4015941A (en) * 1975-01-29 1977-04-05 Japan Medical Supply Co., Ltd. Test tube assembly
US4021124A (en) * 1975-02-27 1977-05-03 Kunststoff-Spritzgusswerk Vessels for the optical observation of liquids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0084557A4 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252623A3 (en) * 1986-07-10 1988-11-17 Technicon Instruments Corporation Microsample cup for liquid analysis systems microsample cup for liquid analysis systems
WO1990000442A1 (fr) * 1988-07-07 1990-01-25 Walter Sarstedt Geräte und Verbrauchsmaterial für Medizin und Wissenschaft Reacteur pour quantites minimes d'echantillons fluides
US5167929A (en) * 1988-07-07 1992-12-01 Walter Sarstedt Geraete Und Verbrauchsmaterial Fuer Medizin Und Wissenshaft Reaction vessel for receiving minimal quantities of fluid samples
EP0434147A3 (en) * 1989-12-22 1991-10-09 Eastman Kodak Company Kit of collection vessels of uniform outside dimensions, different volumes
EP0819941A3 (fr) * 1991-03-04 1998-11-18 Ciba Corning Diagnostics Corp. Conteneur pour réactif avec convercle
US6074615A (en) * 1991-03-04 2000-06-13 Bayer Corporation Reagent container for an automated analyzer
US6436349B1 (en) 1991-03-04 2002-08-20 Bayer Corporation Fluid handling apparatus for an automated analyzer
US6555062B1 (en) 1991-03-04 2003-04-29 Bayer Corporation Reagent container for an automated analyzer
US7182912B2 (en) 1991-03-04 2007-02-27 Bayer Corporation Fluid handling apparatus for an automated analyzer
FR2688888A1 (fr) * 1992-03-23 1993-09-24 Boy Sa Inst Jacques Dispositif destine notamment a la mise en óoeuvre de microtechniques d'analyse.
EP0564383A1 (fr) * 1992-03-23 1993-10-06 Institut Jacques Boy Dispositif destiné notamment à la mise en oeuvre de microtechniques d'analyse

Also Published As

Publication number Publication date
JPS58501146A (ja) 1983-07-14
EP0084557A1 (fr) 1983-08-03
ES275137U (es) 1984-02-01
EP0084557A4 (fr) 1985-09-16
ES275137Y (es) 1984-10-01

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