[go: up one dir, main page]

UY35906A - Novedosos derivados de bencimidazol como ligandos de ep4 - Google Patents

Novedosos derivados de bencimidazol como ligandos de ep4

Info

Publication number
UY35906A
UY35906A UY0001035906A UY35906A UY35906A UY 35906 A UY35906 A UY 35906A UY 0001035906 A UY0001035906 A UY 0001035906A UY 35906 A UY35906 A UY 35906A UY 35906 A UY35906 A UY 35906A
Authority
UY
Uruguay
Prior art keywords
ligandos
bencimidazol
news
derived
preparation
Prior art date
Application number
UY0001035906A
Other languages
English (en)
Inventor
Bothe Ulrich
Dr Marcus Koppitz
Dr Olaf Peters
Dr Nico Bräuer
Dr Jens Nagel
Dr Gernot Langer
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of UY35906A publication Critical patent/UY35906A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a novedosos derivados de bencimidazol de la fórmula general (I), a procedimientos para su preparación, así como su uso para la preparación de agentes farmacéuticos para el tratamiento de enfermedades e indicaciones que están relacionadas con el receptor EP4.
UY0001035906A 2013-12-19 2014-12-19 Novedosos derivados de bencimidazol como ligandos de ep4 UY35906A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13198448 2013-12-19

Publications (1)

Publication Number Publication Date
UY35906A true UY35906A (es) 2015-07-31

Family

ID=49876417

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001035906A UY35906A (es) 2013-12-19 2014-12-19 Novedosos derivados de bencimidazol como ligandos de ep4

Country Status (11)

Country Link
US (1) US10730856B2 (es)
EP (1) EP3083603B1 (es)
JP (1) JP6411513B2 (es)
CN (1) CN105814038B (es)
AR (1) AR098843A1 (es)
CA (1) CA2934094C (es)
ES (1) ES2651857T3 (es)
HK (1) HK1223355A1 (es)
TW (1) TW201607943A (es)
UY (1) UY35906A (es)
WO (1) WO2015091475A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA115576C2 (uk) * 2012-12-06 2017-11-27 Байєр Фарма Акцієнгезелльшафт Похідні бензимідазолу як антагоністи ер4
TW201607943A (zh) 2013-12-19 2016-03-01 拜耳製藥公司 作為ｅｐ４配體之新穎苯并咪唑衍生物
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
WO2018162562A1 (en) * 2017-03-10 2018-09-13 Bayer Pharma Aktiengesellschaft Use of an ep4 antagonist for the treatment of inflammatory pain
EP3625223B1 (en) 2017-05-18 2021-08-11 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
HUE056080T2 (hu) 2017-05-18 2022-01-28 Idorsia Pharmaceuticals Ltd Fenilszármazékok mint PGE2 receptor modulátorok
CN110621666A (zh) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 N-取代吲哚衍生物
TW201900178A (zh) 2017-05-18 2019-01-01 瑞士商愛杜西亞製藥有限公司 作為pge2受體調節劑之嘧啶衍生物
AR111807A1 (es) 2017-05-18 2019-08-21 Idorsia Pharmaceuticals Ltd Derivados de benzofurano y benzotiofeno como moduladores del receptor pge2
US20230390303A1 (en) 2020-11-13 2023-12-07 Ono Pharmaceutical Co., Ltd. Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor
CN114249660B (zh) * 2021-12-10 2024-04-09 浙江工业大学 一种利用含醚键醇类衍生物的n-烷基化反应制备含醚芳胺衍生物的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6000900A (en) * 1999-07-23 2001-02-13 Astrazeneca Uk Limited Carbazole derivatives and their use as neuropeptide y5 receptor ligands
IL150775A0 (en) 2000-01-18 2003-02-12 Schering Ag Drospirenone for hormone replacement therapy
HN2001000224A (es) 2000-10-19 2002-06-13 Pfizer Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
AR035543A1 (es) 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
NZ535748A (en) 2002-04-12 2007-06-29 Pfizer Use of EP4 receptor ligands in the treatment of IL-6 involved diseases
US7022714B2 (en) * 2002-07-31 2006-04-04 Euro-Celtique S.A. Aryl substituted benzimidazoles and their use as sodium channel blockers
US6949564B2 (en) 2002-12-18 2005-09-27 Pfizer Inc. NPY-5 antagonists
KR101094003B1 (ko) 2003-01-29 2011-12-15 아스터랜드 유케이 리미티드 Ｅｐ4 수용체 길항제
AU2004268839A1 (en) 2003-09-03 2005-03-10 Pfizer Inc. Phenyl or pyridyl amide compounds as prostaglandin E2 antagonists
MXPA06012172A (es) * 2004-04-20 2007-01-17 Pfizer Prod Inc Combinaciones que comprenden ligandos alfa-2-delta y antagonistas del receptor ep4.
MXPA06012830A (es) 2004-05-04 2007-01-26 Pfizer Compuestos de aril- o heteroaril-amida ortosustituidos.
US7968578B2 (en) 2006-04-24 2011-06-28 Merck Frosst Canada Ltd. Indole amide derivatives as EP4 receptor antagonists
GB0614066D0 (en) * 2006-07-14 2006-08-23 Glaxo Group Ltd Compounds
JP5259592B2 (ja) 2006-08-11 2013-08-07 メルク カナダ インコーポレイテッド Ｅｐ４受容体リガンドとしてのチオフェンカルボキサミド誘導体
AU2008221194B2 (en) 2007-02-26 2013-06-27 Merck Canada Inc. Indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists
DE102007011105A1 (de) 2007-03-02 2008-09-04 Bayer Schering Pharma Aktiengesellschaft Mineralcorticoid-Rezeptor-Antagonisten zur Behandlung von Endometriose
JP5408434B2 (ja) 2007-07-03 2014-02-05 アステラス製薬株式会社 アミド化合物
AU2008284303A1 (en) 2007-08-09 2009-02-12 Merck & Co., Inc. Process for making thiophene carboxamide derivative
TW201029986A (en) * 2008-11-14 2010-08-16 Neurosearch As Novel compounds
WO2010124097A2 (en) 2009-04-22 2010-10-28 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
CA3009937C (en) * 2010-02-22 2020-12-15 Askat Inc. Use of ep4 receptor antagonists in the treatment of il-23 mediated diseases
UA115576C2 (uk) 2012-12-06 2017-11-27 Байєр Фарма Акцієнгезелльшафт Похідні бензимідазолу як антагоністи ер4
TW201607943A (zh) 2013-12-19 2016-03-01 拜耳製藥公司 作為ｅｐ４配體之新穎苯并咪唑衍生物

Also Published As

Publication number Publication date
CA2934094C (en) 2022-07-26
HK1223355A1 (zh) 2017-07-28
ES2651857T3 (es) 2018-01-30
WO2015091475A1 (de) 2015-06-25
US20160318905A1 (en) 2016-11-03
CN105814038B (zh) 2018-12-04
JP6411513B2 (ja) 2018-10-24
JP2017500327A (ja) 2017-01-05
CA2934094A1 (en) 2015-06-25
EP3083603B1 (de) 2017-09-13
EP3083603A1 (de) 2016-10-26
US10730856B2 (en) 2020-08-04
AR098843A1 (es) 2016-06-15
TW201607943A (zh) 2016-03-01
CN105814038A (zh) 2016-07-27

Similar Documents

Publication Publication Date Title
CR20150296A (es) Novedosos derivados de bencimidazol como antagonistas de ep4
UY35906A (es) Novedosos derivados de bencimidazol como ligandos de ep4
SV2017005487A (es) Derivados de 4h-pirrol[3,2-c]piridin-4-ona
DOP2017000078A (es) Indazoles sustituidos con bencilo como inhibidores de bub1.
DOP2016000144A (es) Moduladores de tetrahidropiridopirazinas de gpr6
DOP2015000270A (es) Potenciador de inhibidores del homólogo de zeste
GT201400063A (es) Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas
CR20150370A (es) Compuestos antivirales
UY35500A (es) Indazoles sustituidos con heteroarilo
UY35467A (es) Compuestos orgánicos
PE20151067A1 (es) Inhibidores de autotaxina
DOP2014000115A (es) Uso de 4-fenil-piridinas sustituidas para la fabricación de medicamentos útiles en el tratamiento de enfermedades relacionadas con el receptor de nk1
UY34602A (es) ?Derivados de bencimidazolil- e imidazopiridinil-metilamina?
EA201591728A1 (ru) Гетероциклические соединения и способы их применения
UY34955A (es) 4-metil-2,3,5,9,9b-pentaaza-ciclopenta[a]naftalenos
CR20140257A (es) Nuevos 2h-indazoles como antagonistas del receptor ep2
SV2018005760A (es) Derivados de aminotiazol utiles como agentes antiviricos
NI201500050A (es) Benzamidas
CR20150248A (es) Derivados de oxazolidin-2-ona-pirimidina
UY34314A (es) Derivados de anilina, su preparación y su aplicación terapéutica.
MX2017007377A (es) Compuestos organicos.
ECSP13013016A (es) Derivados de 2-amino-3-(imidazol-2-il)-piridin-4-ona, y su uso como inhibidores de la cinasa del receptor vegf
MX372922B (es) Un derivado de la cromona como el antagonista del receptor de la dopamina d3 para su uso en el tratamiento del trastorno del espectro autista.
CU20140058A7 (es) Nuevos 2h-indizoles como antagonistas del receptor ep-2
UY35443A (es) Derivados oxindol con un sustituyente oxetano y uso de los mismos para tratar enfermedades relacionadas con la vasopresina

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20211230