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UY34725A - Nuevos derivados de tienopirimidina, procesos para su preparación y sus usos terapéuticos. - Google Patents

Nuevos derivados de tienopirimidina, procesos para su preparación y sus usos terapéuticos.

Info

Publication number
UY34725A
UY34725A UY0001034725A UY34725A UY34725A UY 34725 A UY34725 A UY 34725A UY 0001034725 A UY0001034725 A UY 0001034725A UY 34725 A UY34725 A UY 34725A UY 34725 A UY34725 A UY 34725A
Authority
UY
Uruguay
Prior art keywords
tienopirimidine
processes
preparation
therapeutic uses
new derivatives
Prior art date
Application number
UY0001034725A
Other languages
English (en)
Inventor
Olivier Duclos
Carry Jean-Christophe
Fabienne Chatreaux
Deprets Stephanie
Vincent Leroy
Sergio Mallart
Melon-Manguer Dominique
Mendez-Perez Maria
Fabrice Vergne
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48095815&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY34725(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of UY34725A publication Critical patent/UY34725A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula I,en la que R6 es -CONH2 o un grupo -C(R¿)(R¿)(OH); R es un grupo fenilo o heteroarilo sustituido; R7 es un grupo arilo o heteroarilo opcionalmente sustituido. Procesos para su preparación y su uso terapéutico.
UY0001034725A 2012-04-03 2013-04-03 Nuevos derivados de tienopirimidina, procesos para su preparación y sus usos terapéuticos. UY34725A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1253044A FR2988722B1 (fr) 2012-04-03 2012-04-03 Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques

Publications (1)

Publication Number Publication Date
UY34725A true UY34725A (es) 2013-09-30

Family

ID=48095815

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001034725A UY34725A (es) 2012-04-03 2013-04-03 Nuevos derivados de tienopirimidina, procesos para su preparación y sus usos terapéuticos.

Country Status (38)

Country Link
US (6) US9115140B2 (es)
EP (1) EP2834248B1 (es)
JP (1) JP6096278B2 (es)
KR (1) KR102039764B1 (es)
CN (2) CN104540834B (es)
AR (1) AR090572A1 (es)
AU (1) AU2013244992B2 (es)
BR (1) BR112014024489B1 (es)
CA (1) CA2868685C (es)
CL (1) CL2014002661A1 (es)
CO (1) CO7091179A2 (es)
CR (1) CR20140435A (es)
CY (1) CY1117843T1 (es)
DK (1) DK2834248T3 (es)
DO (1) DOP2014000216A (es)
EA (1) EA025558B1 (es)
ES (1) ES2577382T3 (es)
FR (1) FR2988722B1 (es)
HK (2) HK1201263A1 (es)
HR (1) HRP20160649T1 (es)
HU (1) HUE027895T2 (es)
IL (1) IL234960A (es)
MA (1) MA37384B1 (es)
MX (1) MX355104B (es)
MY (1) MY166151A (es)
PE (1) PE20150289A1 (es)
PH (1) PH12014502180A1 (es)
PL (1) PL2834248T3 (es)
PT (1) PT2834248E (es)
RS (1) RS54850B1 (es)
SG (1) SG11201406091RA (es)
SI (1) SI2834248T1 (es)
TN (1) TN2014000415A1 (es)
TW (1) TWI579288B (es)
UA (1) UA112685C2 (es)
UY (1) UY34725A (es)
WO (1) WO2013150036A1 (es)
ZA (1) ZA201407021B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2988722B1 (fr) 2012-04-03 2014-05-09 Sanofi Sa Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques
JP2017516855A (ja) * 2014-05-28 2017-06-22 シャンハイ フォチョン ファーマシューティカル カンパニー リミテッド 特定のタンパク質キナーゼ阻害剤
JP6966423B2 (ja) * 2015-04-24 2021-11-17 グアンジョウ マキシノベル ファーマシューティカルズ カンパニー リミテッド 縮合環ピリミジンアミノ誘導体、その製造方法、中間体、薬学的組成物及び応用
WO2017114351A1 (en) * 2015-12-27 2017-07-06 Chongqing Fochon Pharmaceutical Co., Ltd. Certain protein kinase inhibitors
AU2017262155B2 (en) * 2016-05-07 2021-03-11 Fochon Pharmaceuticals, Ltd. Certain protein kinase inhibitors
WO2019054427A1 (ja) 2017-09-14 2019-03-21 第一三共株式会社 環状構造を有する化合物
CN112074505B (zh) 2018-03-08 2024-04-05 因赛特公司 作为PI3K-γ抑制剂的氨基吡嗪二醇化合物
CN110551142B (zh) 2018-05-31 2023-05-12 上海再极医药科技有限公司 一种稠环嘧啶类化合物的盐、晶型及其制备方法和应用
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CN110922421B (zh) * 2019-12-17 2023-05-05 安徽英特美科技有限公司 一种n-甲基-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯的合成方法
CN113384582A (zh) * 2020-03-13 2021-09-14 广州再极医药科技有限公司 稠环嘧啶化合物在制备治疗癌症的药物中的应用
WO2023169461A1 (zh) * 2022-03-08 2023-09-14 广州再极医药科技有限公司 一种噻吩并嘧啶类化合物、中间体、其制备方法、组合物和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470356A1 (de) * 1964-01-15 1970-04-30 Thomae Gmbh Dr K Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung
EA005889B1 (ru) * 1997-11-11 2005-06-30 Пфайзер Продактс Инк. Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов
WO2000075145A1 (en) 1999-06-03 2000-12-14 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
DE10042997A1 (de) 2000-09-01 2002-03-14 Merck Patent Gmbh Thienopyrimidine
US20080108611A1 (en) 2006-01-19 2008-05-08 Battista Kathleen A Substituted thienopyrimidine kinase inhibitors
WO2007127183A1 (en) 2006-04-26 2007-11-08 Genentech, Inc. Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them
PT2091918E (pt) 2006-12-08 2014-11-24 Irm Llc Compostos e composições como inibidores de proteína cinase
WO2009062258A1 (en) * 2007-11-15 2009-05-22 Cytopia Research Pty Ltd N-containing heterocyclic compounds
DE102008017853A1 (de) 2008-04-09 2009-10-15 Merck Patent Gmbh Thienopyrimidine
KR101147550B1 (ko) * 2009-10-22 2012-05-17 한국과학기술연구원 단백질 키나아제 저해활성을 가지는 2,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
KR101094446B1 (ko) * 2009-11-19 2011-12-15 한국과학기술연구원 단백질 키나아제 저해활성을 가지는 2,4,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
WO2012004900A1 (en) 2010-07-09 2012-01-12 Aska Pharmaceutical Co., Ltd. Thienopyrimidine compounds
FR2988722B1 (fr) 2012-04-03 2014-05-09 Sanofi Sa Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques

Also Published As

Publication number Publication date
WO2013150036A1 (en) 2013-10-10
PL2834248T3 (pl) 2016-09-30
CO7091179A2 (es) 2014-10-21
US20150352124A1 (en) 2015-12-10
ES2577382T3 (es) 2016-07-14
SI2834248T1 (sl) 2016-07-29
EA201491820A1 (ru) 2015-02-27
PT2834248E (pt) 2016-06-24
TN2014000415A1 (en) 2015-12-21
US20200323874A1 (en) 2020-10-15
PE20150289A1 (es) 2015-03-05
SG11201406091RA (en) 2014-10-30
US10736904B2 (en) 2020-08-11
MA37384A1 (fr) 2016-06-30
CY1117843T1 (el) 2017-05-17
US10220044B2 (en) 2019-03-05
JP2015512434A (ja) 2015-04-27
CN104540834B (zh) 2017-11-14
US10500212B2 (en) 2019-12-10
FR2988722B1 (fr) 2014-05-09
FR2988722A1 (fr) 2013-10-04
EP2834248B1 (en) 2016-03-16
KR102039764B1 (ko) 2019-11-01
CN104540834A (zh) 2015-04-22
UA112685C2 (uk) 2016-10-10
TWI579288B (zh) 2017-04-21
US20170319594A1 (en) 2017-11-09
EP2834248A1 (en) 2015-02-11
MX2014011921A (es) 2015-02-24
JP6096278B2 (ja) 2017-03-15
BR112014024489B1 (pt) 2020-11-10
US10980816B2 (en) 2021-04-20
PH12014502180B1 (en) 2014-12-10
CA2868685C (en) 2021-01-12
US9744176B2 (en) 2017-08-29
CL2014002661A1 (es) 2014-12-26
CN107652303B (zh) 2020-08-04
US20130261106A1 (en) 2013-10-03
AU2013244992B2 (en) 2017-04-20
KR20150001781A (ko) 2015-01-06
HK1201263A1 (zh) 2015-08-28
DK2834248T3 (en) 2016-07-04
MY166151A (en) 2018-06-06
ZA201407021B (en) 2015-11-25
AR090572A1 (es) 2014-11-19
HK1248214A1 (zh) 2018-10-12
IL234960A (en) 2017-06-29
MX355104B (es) 2018-04-05
US20190151330A1 (en) 2019-05-23
MA37384B1 (fr) 2017-03-31
US9115140B2 (en) 2015-08-25
AU2013244992A1 (en) 2014-10-23
DOP2014000216A (es) 2017-09-15
RS54850B1 (sr) 2016-10-31
CR20140435A (es) 2015-03-13
EA025558B1 (ru) 2017-01-30
CA2868685A1 (en) 2013-10-10
HUE027895T2 (en) 2016-10-28
US20200078370A1 (en) 2020-03-12
CN107652303A (zh) 2018-02-02
PH12014502180A1 (en) 2014-12-10
HRP20160649T1 (hr) 2016-07-15
TW201345914A (zh) 2013-11-16

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20210526