UY31689A1 - Derivados de platino-carbeno n-heterocíclico, su preparación y su aplicación en terapéutica - Google Patents
Derivados de platino-carbeno n-heterocíclico, su preparación y su aplicación en terapéuticaInfo
- Publication number
- UY31689A1 UY31689A1 UY031689A UY31689A UY31689A1 UY 31689 A1 UY31689 A1 UY 31689A1 UY 031689 A UY031689 A UY 031689A UY 31689 A UY31689 A UY 31689A UY 31689 A1 UY31689 A1 UY 31689A1
- Authority
- UY
- Uruguay
- Prior art keywords
- preparation
- platinum
- therapeutics
- heterocyclic
- application
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 1
- 150000003057 platinum Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invención se refiere a los derivados de platino carbenoN-heterociclo o NHC-Pt, de fórmula general (I), en forma de hidratos o de solvatos, la que los sustituyentes y radicales son tales como se han especificado en la Memoria Descriptiva y en las Reivindicaciones ; y se refiere también a su preparación y a su aplicación terapéutica en el tratamiento del cáncer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0801155A FR2928151B1 (fr) | 2008-03-03 | 2008-03-03 | Derives platine-carbene n-heterocyclique, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31689A1 true UY31689A1 (es) | 2009-09-30 |
Family
ID=39739698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY031689A UY31689A1 (es) | 2008-03-03 | 2009-03-03 | Derivados de platino-carbeno n-heterocíclico, su preparación y su aplicación en terapéutica |
Country Status (9)
Country | Link |
---|---|
US (2) | US8481522B2 (es) |
EP (1) | EP2268652B1 (es) |
JP (1) | JP5385923B2 (es) |
AR (1) | AR070733A1 (es) |
CL (1) | CL2009000502A1 (es) |
FR (1) | FR2928151B1 (es) |
TW (1) | TW200944199A (es) |
UY (1) | UY31689A1 (es) |
WO (1) | WO2009118475A2 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8168794B2 (en) | 2008-03-03 | 2012-05-01 | Novartis Ag | Pim kinase inhibitors and methods of their use |
FR2928151B1 (fr) * | 2008-03-03 | 2010-12-31 | Sanofi Aventis | Derives platine-carbene n-heterocyclique, leur preparation et leur application en therapeutique |
WO2011050574A1 (en) * | 2009-10-28 | 2011-05-05 | The University Of Hong Kong | Pharmaceutical composition containing cyclometalated n-heterocyclic carbene complexes for cancer treatment |
FR2969615B1 (fr) * | 2010-12-23 | 2013-10-25 | Centre Nat Rech Scient | Nouveau complexes carbeniques de platine et leur utilisation comme medicaments |
FR2969616B1 (fr) * | 2010-12-23 | 2013-01-11 | Centre Nat Rech Scient | Procede de preparation de complexes carbeniques de platine |
CN102206226B (zh) * | 2011-04-14 | 2013-10-23 | 天津师范大学 | 三甲基苯连接的氮杂环卡宾金属配合物及其制备方法 |
TW201408641A (zh) | 2012-05-21 | 2014-03-01 | Novartis Ag | 可作爲激酶抑制劑之新穎環取代n-吡啶基醯胺 |
CN106659765B (zh) | 2014-04-04 | 2021-08-13 | 德玛医药 | 二脱水半乳糖醇及其类似物或衍生物用于治疗非小细胞肺癌和卵巢癌的用途 |
WO2016004324A1 (en) | 2014-07-02 | 2016-01-07 | University Of Florida Research Foundation, Inc. | Aptamer conjugates with n-heterocyclic carbene metal complexes for targeted drug delivery |
CN106008609B (zh) * | 2016-05-31 | 2018-11-06 | 安徽大学 | 一种环金属铂配合物及其制备方法 |
CN108689939A (zh) * | 2017-04-07 | 2018-10-23 | 厦门华绰生物医药科技有限公司 | 取代咪唑盐类化合物、其制备方法、药用组合物及其应用 |
CN114375294B (zh) * | 2019-09-19 | 2024-06-28 | 香港大学 | 用于探测错配的dna的颜色可调的发光二齿铂(ii)配合物 |
WO2022084325A1 (en) | 2020-10-20 | 2022-04-28 | Institut Curie | Metallic trans-(n-heterocyclic carbene)-amine-platinum complexes and uses thereof for treating cancer |
CN116143842A (zh) * | 2023-01-10 | 2023-05-23 | 广西师范大学 | 氧化异阿朴菲生物碱与n-杂环卡宾的环金属铱配合物及其合成方法和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4447066A1 (de) * | 1994-12-29 | 1996-07-04 | Hoechst Ag | Heterocyclische Carbene enthaltende Metallkomplexverbindungen |
FR2825707B1 (fr) | 2001-06-07 | 2004-11-26 | Rhodia Chimie Sa | Procede de preparation de catalyseurs metalliques a base de carbenes, pour l'hydrosilylation de composes insatures et catalyseurs de ce type |
FR2928151B1 (fr) * | 2008-03-03 | 2010-12-31 | Sanofi Aventis | Derives platine-carbene n-heterocyclique, leur preparation et leur application en therapeutique |
-
2008
- 2008-03-03 FR FR0801155A patent/FR2928151B1/fr not_active Expired - Fee Related
-
2009
- 2009-03-02 EP EP09724326A patent/EP2268652B1/fr active Active
- 2009-03-02 WO PCT/FR2009/000220 patent/WO2009118475A2/fr active Application Filing
- 2009-03-02 AR ARP090100729A patent/AR070733A1/es not_active Application Discontinuation
- 2009-03-02 JP JP2010549173A patent/JP5385923B2/ja not_active Expired - Fee Related
- 2009-03-03 CL CL2009000502A patent/CL2009000502A1/es unknown
- 2009-03-03 UY UY031689A patent/UY31689A1/es not_active Application Discontinuation
- 2009-03-03 TW TW098106864A patent/TW200944199A/zh unknown
-
2010
- 2010-09-02 US US12/874,815 patent/US8481522B2/en not_active Expired - Fee Related
-
2013
- 2013-06-21 US US13/923,540 patent/US8980875B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2928151B1 (fr) | 2010-12-31 |
FR2928151A1 (fr) | 2009-09-04 |
EP2268652A2 (fr) | 2011-01-05 |
WO2009118475A2 (fr) | 2009-10-01 |
JP2011513373A (ja) | 2011-04-28 |
US20130338128A1 (en) | 2013-12-19 |
CL2009000502A1 (es) | 2010-03-05 |
AR070733A1 (es) | 2010-04-28 |
US8481522B2 (en) | 2013-07-09 |
WO2009118475A3 (fr) | 2009-11-19 |
US8980875B2 (en) | 2015-03-17 |
EP2268652B1 (fr) | 2012-12-19 |
JP5385923B2 (ja) | 2014-01-08 |
US20110172199A1 (en) | 2011-07-14 |
TW200944199A (en) | 2009-11-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20140808 |