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UY27918A1 - Derivados de benzodioxol - Google Patents

Derivados de benzodioxol

Info

Publication number
UY27918A1
UY27918A1 UY27918A UY27918A UY27918A1 UY 27918 A1 UY27918 A1 UY 27918A1 UY 27918 A UY27918 A UY 27918A UY 27918 A UY27918 A UY 27918A UY 27918 A1 UY27918 A1 UY 27918A1
Authority
UY
Uruguay
Prior art keywords
compounds
benzodioxol derivatives
benzodioxol
derivatives
prophylaxis
Prior art date
Application number
UY27918A
Other languages
English (en)
Inventor
Alexander Alanine
Thomas Luebbers
Dagmar Kube
Gisbert Schneider
Jean-Marc Plancher
Konrad Bleicher
Mark Rogers-Evans
Olivier Roche
Wolfgang Guba
Wolfgang Haap
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY27918A1 publication Critical patent/UY27918A1/es

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    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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Abstract

La presente invención se refiere a compuestos de la fórmula (I) en la que R1, R2, R3, R4, R5, R6, R7 y X tienen los significados definidos en la descripción y las reivindicaciones, y las sales farmacéuticamente aceptables de los mismos. Dichos compuestos son útiles para el tratamiento y/o profilaxis de enfermedades asociadas con la modulación de receptores CB1.
UY27918A 2002-07-29 2003-07-31 Derivados de benzodioxol UY27918A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02016831 2002-07-29

Publications (1)

Publication Number Publication Date
UY27918A1 true UY27918A1 (es) 2003-12-31

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UY27918A UY27918A1 (es) 2002-07-29 2003-07-31 Derivados de benzodioxol

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US (2) US6900227B2 (es)
EP (1) EP1532132B1 (es)
JP (1) JP4202319B2 (es)
KR (1) KR100741231B1 (es)
CN (1) CN100486973C (es)
AR (1) AR040694A1 (es)
AT (1) ATE389646T1 (es)
AU (1) AU2003250117B2 (es)
BR (1) BR0313041A (es)
CA (1) CA2493313C (es)
DE (1) DE60319837T2 (es)
ES (1) ES2301833T3 (es)
HR (1) HRP20050044A2 (es)
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MY (1) MY135841A (es)
NZ (1) NZ537685A (es)
PA (1) PA8578601A1 (es)
PE (1) PE20040720A1 (es)
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RU (1) RU2304580C2 (es)
TW (1) TW200413345A (es)
UY (1) UY27918A1 (es)
WO (1) WO2004013120A1 (es)
ZA (1) ZA200500340B (es)

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ATE478856T1 (de) * 2004-01-28 2010-09-15 Hoffmann La Roche Spirobenzodioxole und deren verwendung als cb1- antagonisten
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
JP2008515956A (ja) * 2004-10-12 2008-05-15 ノボ ノルディスク アクティーゼルスカブ １１β−ヒドロキシステロイドデヒドロゲナーゼ１型活性スピロ化合物
WO2006050842A1 (en) 2004-11-09 2006-05-18 F. Hoffmann-La Roche Ag Dibenzosuberone derivatives
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