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UY27388A1 - Nuevos compuestos - Google Patents

Nuevos compuestos

Info

Publication number
UY27388A1
UY27388A1 UY27388A UY27388A UY27388A1 UY 27388 A1 UY27388 A1 UY 27388A1 UY 27388 A UY27388 A UY 27388A UY 27388 A UY27388 A UY 27388A UY 27388 A1 UY27388 A1 UY 27388A1
Authority
UY
Uruguay
Prior art keywords
compounds
new compounds
formula
preparation
present
Prior art date
Application number
UY27388A
Other languages
English (en)
Inventor
Takehiro Okada
Fumio Watanabe
Mikio Taniguchi
Toshihiko Fujii
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY27388A1 publication Critical patent/UY27388A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a nuevos compuestos de fórmula I, con actividad anti-tumoral, en donde R1, R2, R3, R4, R5 y n son tal como se describen en la descripción y las reivindicaciones y las sales farmacéuticamente aceptables de las mismas. La presente invención concierne también a la composición farmacéutica que comprende compuestos de fórmula (I), el uso de compuestos de fórmula (I) para la preparación de medicamentos y procesos para la preparación de compuestos (I).
UY27388A 2001-07-19 2002-07-17 Nuevos compuestos UY27388A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01117410 2001-07-19

Publications (1)

Publication Number Publication Date
UY27388A1 true UY27388A1 (es) 2003-01-31

Family

ID=8178073

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27388A UY27388A1 (es) 2001-07-19 2002-07-17 Nuevos compuestos

Country Status (30)

Country Link
US (1) US6737409B2 (es)
EP (1) EP1412328B1 (es)
JP (1) JP2004534859A (es)
KR (2) KR20060057652A (es)
CN (1) CN1553897A (es)
AR (1) AR036175A1 (es)
AT (1) ATE341537T1 (es)
BR (1) BR0211289A (es)
CA (1) CA2453987A1 (es)
CO (1) CO5550462A2 (es)
DE (1) DE60215179T2 (es)
DK (1) DK1412328T3 (es)
ES (1) ES2272763T3 (es)
GT (1) GT200200154A (es)
HR (1) HRP20040043A2 (es)
HU (1) HUP0401253A2 (es)
IL (1) IL159890A0 (es)
MX (1) MXPA04000577A (es)
MY (1) MY127718A (es)
NO (1) NO20040198L (es)
NZ (1) NZ530655A (es)
PA (1) PA8551001A1 (es)
PE (1) PE20030258A1 (es)
PL (1) PL367682A1 (es)
PT (1) PT1412328E (es)
RU (1) RU2296750C2 (es)
SI (1) SI1412328T1 (es)
UY (1) UY27388A1 (es)
WO (1) WO2003008378A1 (es)
ZA (1) ZA200400334B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7256257B2 (en) 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
NZ535139A (en) 2002-03-22 2007-07-27 Eisai Co Ltd Hemiasterlin derivatives and uses thereof in the treatment of cancer
US7064211B2 (en) 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
WO2004010957A2 (en) 2002-07-31 2004-02-05 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
AU2004316290C1 (en) 2003-11-06 2012-02-02 Seagen Inc. Monomethylvaline compounds capable of conjugation to ligands
CA2567914A1 (en) * 2004-06-02 2005-12-15 F. Hoffmann-La Roche Ag Synthesis of amino-alkoxy-heptanoic alkyl ester
AU2005332660A1 (en) 2004-11-12 2006-12-14 Seattle Genetics, Inc. Auristatins having an aminobenzoic acid unit at the N terminus
KR20070086128A (ko) * 2004-12-13 2007-08-27 에프. 호프만-라 로슈 아게 3-피롤리딘-2-일-프로피온산 유도체의 신규 제조 방법
WO2006063707A2 (en) * 2004-12-13 2006-06-22 F. Hoffmann-La Roche Ag Novel pharmaceutical composition containing at least one dolastatin 10 derivative
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
CN101102993A (zh) * 2005-01-13 2008-01-09 霍夫曼-拉罗奇有限公司 有用的双取代胺类的新型一步合成
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
WO2007008603A1 (en) * 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
US8871720B2 (en) * 2005-07-07 2014-10-28 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
KR101506466B1 (ko) 2006-05-16 2015-03-27 파마사이언스 인크. Ｉａｐ ｂｉｒ 도메인 결합 화합물
US20080003652A1 (en) * 2006-06-28 2008-01-03 Hans Iding Novel enzymatic process for the manufacture of Boc-Dap-Oh priority to related application(s)
SI2474557T1 (sl) 2007-07-16 2014-12-31 Genentech, Inc. Protiteles proti CD79b in imunokonjugati in postopki za uporabo
CN101802013B (zh) 2007-07-16 2014-07-02 健泰科生物技术公司 人源化抗cd79b抗体和免疫偶联物及使用方法
EP2247620B1 (en) 2008-01-31 2016-05-18 Genentech, Inc. Anti-cd79b antibodies and immunoconjugates and methods of use
CA2718942A1 (en) 2008-03-18 2009-09-24 Seattle Genetics, Inc. Auristatin drug linker conjugates
KR20130009760A (ko) 2010-02-10 2013-01-23 이뮤노젠 아이엔씨 Ｃｄ２０ 항체 및 이의 용도
AU2011214057B2 (en) 2010-02-12 2016-11-17 Pharmascience Inc. IAP BIR domain binding compounds
US8722629B2 (en) 2010-06-10 2014-05-13 Seattle Genetics, Inc. Auristatin derivatives and use thereof
JP5933562B2 (ja) 2010-09-29 2016-06-15 シアトル ジェネティックス， インコーポレイテッド Ｎ−カルボキシアルキル−アウリスタチンおよびその使用
ES2543888T3 (es) 2011-03-16 2015-08-25 Seattle Genetics, Inc. N-carboxialquil-auristatinas y su utilización
AU2012262560B2 (en) 2011-05-27 2016-06-09 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
MX371526B (es) * 2011-05-27 2020-01-31 Ambrx Inc Composiciones que contienen, metodos que incluyen, y usos de derivados de dolastatina enlazados a aminoacidos no naturales.
KR101520302B1 (ko) 2012-09-20 2015-05-15 (주)셀트리온 돌라스타틴 10 유도체, 그의 제조방법 및 그를 포함하는 항암제 조성물
CA2935077C (en) 2013-12-27 2022-03-15 Geoffrey C. Winters Sulfonamide-containing linkage systems for drug conjugates
US20160082120A1 (en) 2014-09-23 2016-03-24 Genentech, Inc. METHODS OF USING ANTI-CD79b IMMUNOCONJUGATES
CN105949277B (zh) * 2015-05-05 2019-03-01 成都永泰诺科技有限公司 一种抗肿瘤化合物及其用途
EP3438118B1 (en) * 2016-03-29 2023-03-29 Toray Industries, Inc. Peptide derivative and use thereof
CN109021065B (zh) * 2017-06-08 2021-10-01 复旦大学 一种制备海兔毒素Dolastatin10的方法
KR20240051956A (ko) 2021-09-03 2024-04-22 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323315B1 (en) 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides

Also Published As

Publication number Publication date
EP1412328B1 (en) 2006-10-04
NO20040198L (no) 2004-02-19
AR036175A1 (es) 2004-08-18
KR20040023661A (ko) 2004-03-18
JP2004534859A (ja) 2004-11-18
WO2003008378A1 (en) 2003-01-30
ES2272763T3 (es) 2007-05-01
US6737409B2 (en) 2004-05-18
MY127718A (en) 2006-12-29
ATE341537T1 (de) 2006-10-15
DE60215179D1 (de) 2006-11-16
CN1553897A (zh) 2004-12-08
GT200200154A (es) 2003-05-16
BR0211289A (pt) 2004-08-03
HUP0401253A2 (hu) 2004-12-28
CO5550462A2 (es) 2005-08-31
DK1412328T3 (da) 2007-02-12
PE20030258A1 (es) 2003-03-19
NZ530655A (en) 2006-08-31
ZA200400334B (en) 2005-06-29
PL367682A1 (en) 2005-03-07
MXPA04000577A (es) 2004-04-20
IL159890A0 (en) 2004-06-20
KR20060057652A (ko) 2006-05-26
RU2296750C2 (ru) 2007-04-10
DE60215179T2 (de) 2007-10-18
PT1412328E (pt) 2007-01-31
US20030055002A1 (en) 2003-03-20
RU2004105145A (ru) 2005-07-10
PA8551001A1 (es) 2003-09-17
SI1412328T1 (sl) 2007-02-28
CA2453987A1 (en) 2003-01-30
KR100611540B1 (ko) 2006-08-10
EP1412328A1 (en) 2004-04-28
HRP20040043A2 (en) 2004-08-31

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20141226