UY27140A1 - VEHICLE WITH SOLID FIBRINOGEN AND SOLID THROMBIN. - Google Patents
VEHICLE WITH SOLID FIBRINOGEN AND SOLID THROMBIN.Info
- Publication number
- UY27140A1 UY27140A1 UY27140A UY27140A UY27140A1 UY 27140 A1 UY27140 A1 UY 27140A1 UY 27140 A UY27140 A UY 27140A UY 27140 A UY27140 A UY 27140A UY 27140 A1 UY27140 A1 UY 27140A1
- Authority
- UY
- Uruguay
- Prior art keywords
- acid
- solid
- vehicle
- fibrinogen
- thrombin
- Prior art date
Links
Landscapes
- Materials For Medical Uses (AREA)
Abstract
La presente invención se refiere a una composición sólida útil para el pegado de tejidos, sellado de tejidos y para Hemostasis, que consiste esencialmente en a) un vehículo que tiene al menos una de las siguientes propiedades físicas: módulo de elasticidad en el intervalo de 5-100 N/cm, densidad de 1-10mg/cm3, diámetro de cámara mayor que 0.75 mm y menor que 4mm y/o que tiene un diámetro medio de cámara inferior a 3mm y distribuido uniformemente y fijado sobre dicho vehículo, b) fibrinógeno sólido, y c) trombina sólida. El vehículo es un polímero biodegradable tal como un ácido polihialurónico, ácido polihidroxilado, por ejemplo ácido láctico, ácido gulocólico, ácido hidroxibutanoico, una celulosa, gelatina o colágeno, tal como una esponja de colágeno que consiste esencialmente en fibras de colágeno de tipo I. El fibrinógeno y la trombina son preferiblemente humanos transgénicos o recombinantes. En una realización preferida, la composición no comprende ningún agente antifibrinolítico tal como aprotinina, ácido e-aminocaproico o alfa2-antiplasmina.The present invention relates to a solid composition useful for tissue bonding, tissue sealing and hemostasis, which essentially consists of a) a vehicle having at least one of the following physical properties: modulus of elasticity in the range of 5 -100 N / cm, density of 1-10mg / cm3, chamber diameter greater than 0.75 mm and less than 4mm and / or having an average chamber diameter less than 3mm and evenly distributed and fixed on said vehicle, b) fibrinogen solid, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxylated acid, for example lactic acid, gulocolic acid, hydroxybutanoic acid, a cellulose, gelatin or collagen, such as a collagen sponge consisting essentially of type I collagen fibers. The fibrinogen and thrombin are preferably transgenic or recombinant human. In a preferred embodiment, the composition does not comprise any antifibrinolytic agent such as aprotinin, e-aminocaproic acid or alpha2-antiplasmin.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100235 | 2001-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY27140A1 true UY27140A1 (en) | 2002-07-31 |
Family
ID=34877998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY27140A UY27140A1 (en) | 2001-02-13 | 2002-01-25 | VEHICLE WITH SOLID FIBRINOGEN AND SOLID THROMBIN. |
Country Status (1)
| Country | Link |
|---|---|
| UY (1) | UY27140A1 (en) |
-
2002
- 2002-01-25 UY UY27140A patent/UY27140A1/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 110 | Patent granted |
Effective date: 20180115 |
|
| VENC | Patent expired |
Effective date: 20220125 |