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UY26988A1 - NEW INDOLINONES REPLACED, ITS PREPARATION AND ITS USE AS MEDICINES. - Google Patents

NEW INDOLINONES REPLACED, ITS PREPARATION AND ITS USE AS MEDICINES.

Info

Publication number
UY26988A1
UY26988A1 UY26988A UY26988A UY26988A1 UY 26988 A1 UY26988 A1 UY 26988A1 UY 26988 A UY26988 A UY 26988A UY 26988 A UY26988 A UY 26988A UY 26988 A1 UY26988 A1 UY 26988A1
Authority
UY
Uruguay
Prior art keywords
preparation
medicines
replaced
indolinones
cell proliferation
Prior art date
Application number
UY26988A
Other languages
Spanish (es)
Inventor
Dr Armin Heckel
Dr Rainer Walter
Dr Jacobus Van Meel
Dr Walter Spevak
Dr Gerald Roth
Dr Jorg Kley
Dr Gisela Schnapp
Dr Martin Lenter
Dr Ulrike Weyer-Czernilofsky
Original Assignee
Boehringer Ingelheim Pharma
Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma, Co Kg filed Critical Boehringer Ingelheim Pharma
Publication of UY26988A1 publication Critical patent/UY26988A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

El invento se refiere a indolinonas sustituidas de la fórmula general (I) sus isómeros y sus sales, en particular sus sales fisiológicamente compatibles, en donde R1, R2, R3, R4, R5, R6 y X presentan el significado indicado en la reivindicación 1, así como procedimientos para su preparación y su utilización. Los nuevos compuestos son valiosos inhibidores de la proliferación de células, especialmente de la proliferación de células de tumores, e inhibidores de proteína - quinasas.The invention relates to substituted indolinones of the general formula (I), their isomers and their salts, in particular their physiologically compatible salts, wherein R1, R2, R3, R4, R5, R6 and X have the meaning indicated in claim 1 , as well as procedures for its preparation and use. The new compounds are valuable inhibitors of cell proliferation, especially tumor cell proliferation, and protein kinase inhibitors.

UY26988A 2000-11-01 2001-10-29 NEW INDOLINONES REPLACED, ITS PREPARATION AND ITS USE AS MEDICINES. UY26988A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10054019A DE10054019A1 (en) 2000-11-01 2000-11-01 New substituted indolinones, their production and their use as medicines

Publications (1)

Publication Number Publication Date
UY26988A1 true UY26988A1 (en) 2002-07-31

Family

ID=7661712

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26988A UY26988A1 (en) 2000-11-01 2001-10-29 NEW INDOLINONES REPLACED, ITS PREPARATION AND ITS USE AS MEDICINES.

Country Status (6)

Country Link
EP (1) EP1341760A1 (en)
JP (1) JP4275942B2 (en)
AU (1) AU2002215980A1 (en)
DE (1) DE10054019A1 (en)
UY (1) UY26988A1 (en)
WO (1) WO2002036564A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10237423A1 (en) 2002-08-16 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Treating immunological (or related) diseases, e.g. inflammatory bowel disease, rheumatoid arthritis or psoriasis, comprises administration of 3-methylene-2-indolinone derivative or quinazoline compound
JP4879492B2 (en) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド Kinase inhibitors for the treatment of diseases
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
FR2866879A1 (en) * 2004-02-27 2005-09-02 Oreal PARA-PHENYLENEDIAMINE SECONDARY N-ALKYLAMINEE, DYEING COMPOSITION OF KERATIN FIBERS CONTAINING SUCH A PARA-PHENYLENEDIAMINE, METHODS USING THE SAME AND USES THEREOF
US7338536B2 (en) 2004-02-27 2008-03-04 L'oreal S. A. N-alkylamino secondary para-phenylenediamine, composition for dyeing keratin fibers comprising such a para-phenylenediamine, processes using this composition and uses thereof
PE20060777A1 (en) 2004-12-24 2006-10-06 Boehringer Ingelheim Int INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
JP2008542433A (en) * 2005-06-09 2008-11-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Α-Carboline as a CDK-1 inhibitor
WO2007057399A2 (en) * 2005-11-15 2007-05-24 Boehringer Ingelheim International Gmbh Treatment of cancer with indole derivatives
JP2009533480A (en) * 2006-04-24 2009-09-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 3- (Aminomethylidene) 2-indolinone derivatives and their use as cytostatics
FR2913019A1 (en) * 2007-02-23 2008-08-29 Cerep Sa New substituted heterocyclic compounds useful for treating/preventing cancer e.g. prostate, lung, breast, colon, skin, kidney and bone cancer, psoriasis, rheumatoid arthritis, Kaposis sarcoma, atherosclerosis and autoimmune diseases
US9487485B2 (en) 2013-02-28 2016-11-08 Takeda Pharmaceutical Company Limited Method for producing sulfonyl chloride compound
US10450295B2 (en) 2013-08-09 2019-10-22 Acclaim BioMed USA LLC Method of using an indolinone molecule and derivatives for inhibiting liver fibrosis and hepatitis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9716557D0 (en) * 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
DE50012136D1 (en) * 1999-08-27 2006-04-13 Boehringer Ingelheim Pharma Substituierte indolinone als tyrosinkinase inhibitoren

Also Published As

Publication number Publication date
JP2004513113A (en) 2004-04-30
EP1341760A1 (en) 2003-09-10
WO2002036564A1 (en) 2002-05-10
AU2002215980A1 (en) 2002-05-15
JP4275942B2 (en) 2009-06-10
DE10054019A1 (en) 2002-05-23

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20160202