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UY26362A1 - Nuevos derivados de la 2, 4, 6 - trione-pirimidina - Google Patents

Nuevos derivados de la 2, 4, 6 - trione-pirimidina

Info

Publication number
UY26362A1
UY26362A1 UY26362A UY26362A UY26362A1 UY 26362 A1 UY26362 A1 UY 26362A1 UY 26362 A UY26362 A UY 26362A UY 26362 A UY26362 A UY 26362A UY 26362 A1 UY26362 A1 UY 26362A1
Authority
UY
Uruguay
Prior art keywords
pirimidina
trione
new derivatives
radical
substituted
Prior art date
Application number
UY26362A
Other languages
English (en)
Inventor
Ernesto Menta
Frank Grams
Gerd Zimermann
Hans-Willi Krell
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of UY26362A1 publication Critical patent/UY26362A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos de la fórmula (I) en la cual r1 representa un radical fenoxilo, feniltio, fenilsufinilo, fenilsulfonilo, fenilamino o fenilmetilo, substituido o sin substituir y r2 representa un radical arilo o heteroarilo, opcionalmente substituido, con actividad como inhibidor de la metalo- proteinasa.
UY26362A 1999-10-01 2000-09-29 Nuevos derivados de la 2, 4, 6 - trione-pirimidina UY26362A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99119506 1999-10-01

Publications (1)

Publication Number Publication Date
UY26362A1 true UY26362A1 (es) 2001-04-30

Family

ID=8239103

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26362A UY26362A1 (es) 1999-10-01 2000-09-29 Nuevos derivados de la 2, 4, 6 - trione-pirimidina

Country Status (29)

Country Link
US (1) US6498252B1 (es)
EP (1) EP1226128B1 (es)
JP (1) JP3848160B2 (es)
KR (1) KR100459975B1 (es)
CN (1) CN1157382C (es)
AR (1) AR033651A1 (es)
AT (1) ATE289595T1 (es)
AU (1) AU768309B2 (es)
BR (1) BR0014678A (es)
CA (1) CA2385863C (es)
CO (1) CO5210860A1 (es)
CZ (1) CZ20021535A3 (es)
DE (1) DE60018301T2 (es)
ES (1) ES2235955T3 (es)
HK (1) HK1050198A1 (es)
HU (1) HUP0202832A3 (es)
IL (1) IL148573A0 (es)
MA (1) MA26823A1 (es)
MX (1) MXPA02003192A (es)
NO (1) NO20021380D0 (es)
NZ (1) NZ517635A (es)
PE (1) PE20010659A1 (es)
PL (1) PL202680B1 (es)
RU (1) RU2248971C2 (es)
TR (1) TR200200858T2 (es)
UY (1) UY26362A1 (es)
WO (1) WO2001025217A1 (es)
YU (1) YU22102A (es)
ZA (1) ZA200201754B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716845B2 (en) * 2001-03-30 2004-04-06 Hoffmann-La Roche Inc. Barbituric acid derivatives
WO2003053940A1 (en) 2001-12-20 2003-07-03 Bristol-Myers Squibb Company Barbituric acid derivatives as inhibitors of tnf-$g(a) converting enzyme (tace) and/or matrix metalloproteinases
WO2004084903A1 (en) * 2003-03-27 2004-10-07 F. Hoffmann-La Roche Ag Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis
WO2004084902A1 (en) * 2003-03-28 2004-10-07 F. Hoffmann-La Roche Ag Use of a trioxopyrimidine for the treatment of chronic wounds
BRPI0509583A (pt) * 2004-04-01 2007-10-09 Hoffmann La Roche composições farmacêuticas de pirimidina-2,4,6-trionas
BRPI0509562A (pt) * 2004-04-01 2007-09-25 Hoffmann La Roche uso de uma trioxopirimidina para o tratamento e a prevenção de doenças inflamatórias brÈnquicas
EP1632489A1 (en) * 2004-08-24 2006-03-08 University of Liege 5-(1,1'-Biphenyl)-4-yl-5-(4-(4-aminoacylphenyl)-piperazin)-1-yl-pyrimidine-2,4,6-trione derivatives, as inhibitors of zinc metallondopeptidases, their preparation and use.
RU2449994C1 (ru) * 2011-03-10 2012-05-10 Светлана Алексеевна Мещерякова 6-(4-бензилпиперазино)-1,3-диметилурацила дигидрохлорид, проявляющий биологическую активность
RU2598607C1 (ru) * 2015-07-16 2016-09-27 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный университет" (Астраханский государственный университет) Способ получения 5-гетарилметиленпиримидин-2,4,6-трионов

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1246743B (de) * 1965-01-12 1967-08-10 Dresden Arzneimittel Verfahren zur Herstellung von 5-Phenyl-5-piperidinobarbitursaeuren
US4595700A (en) 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
GB8726714D0 (en) 1987-11-14 1987-12-16 Beecham Group Plc Compounds
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
US5239078A (en) 1990-11-21 1993-08-24 Glycomed Incorporated Matrix metalloprotease inhibitors
KR927003520A (ko) 1990-12-03 1992-12-18 죤 에드워드 베리만 펩티딜(peptidyl) 유도체
CA2058797A1 (en) 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
US5789434A (en) 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
GEP20012388B (en) 1995-12-08 2001-03-25 Agouron Pharma Metalloproteinase Inhibitors, Pharmaceutical Compositions on Their Base, Use and Methods for Obtaining and Intermediates
DE19548624A1 (de) 1995-12-23 1997-06-26 Boehringer Mannheim Gmbh Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers

Also Published As

Publication number Publication date
HUP0202832A3 (en) 2003-03-28
TR200200858T2 (tr) 2002-07-22
ZA200201754B (en) 2003-06-02
MXPA02003192A (es) 2002-09-30
AU768309B2 (en) 2003-12-04
JP3848160B2 (ja) 2006-11-22
AR033651A1 (es) 2004-01-07
DE60018301T2 (de) 2006-04-06
ATE289595T1 (de) 2005-03-15
AU7784900A (en) 2001-05-10
RU2248971C2 (ru) 2005-03-27
HUP0202832A2 (hu) 2003-02-28
CN1374954A (zh) 2002-10-16
PL202680B1 (pl) 2009-07-31
KR20020039356A (ko) 2002-05-25
CA2385863A1 (en) 2001-04-12
PE20010659A1 (es) 2001-06-20
DE60018301D1 (de) 2005-03-31
CN1157382C (zh) 2004-07-14
NO20021380L (no) 2002-03-20
HK1050198A1 (en) 2003-06-13
CO5210860A1 (es) 2002-10-30
CA2385863C (en) 2009-04-14
US6498252B1 (en) 2002-12-24
CZ20021535A3 (cs) 2002-11-13
EP1226128A1 (en) 2002-07-31
MA26823A1 (fr) 2004-12-20
IL148573A0 (en) 2002-09-12
WO2001025217A1 (en) 2001-04-12
JP2003511376A (ja) 2003-03-25
YU22102A (sh) 2004-11-25
BR0014678A (pt) 2002-07-23
NZ517635A (en) 2003-11-28
NO20021380D0 (no) 2002-03-20
EP1226128B1 (en) 2005-02-23
ES2235955T3 (es) 2005-07-16
KR100459975B1 (ko) 2004-12-03
PL357385A1 (en) 2004-07-26

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20110819