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US8617392B2 - Device and system for filtering blood - Google Patents

Device and system for filtering blood Download PDF

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Publication number
US8617392B2
US8617392B2 US13/347,074 US201213347074A US8617392B2 US 8617392 B2 US8617392 B2 US 8617392B2 US 201213347074 A US201213347074 A US 201213347074A US 8617392 B2 US8617392 B2 US 8617392B2
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Prior art keywords
blood
filtrate
container
filter unit
filter
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Expired - Fee Related
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US13/347,074
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US20120116283A1 (en
Inventor
Anders Nilsson
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Gambro Lundia AB
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Gambro Lundia AB
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Priority to US13/347,074 priority Critical patent/US8617392B2/en
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Priority to US14/096,774 priority patent/US8852433B2/en
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Publication of US8617392B2 publication Critical patent/US8617392B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A61M1/341—Regulation parameters by measuring the filtrate rate or volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/15—Detection of leaks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/08—Supports for equipment
    • A61M2209/088—Supports for equipment on the body

Definitions

  • the invention concerns a device for filtering blood.
  • the invention also concerns a system for ultra filtration of blood including such a device.
  • Hemodialysis treatments are traditionally carried out about three times a week, whereby the blood is purified and the liquid balance is adjusted at a hemodialysis site in a hospital.
  • One condition for hemodialysis is the establishment of a connection to the patient's bloodstream having a sufficience flow. This may be accomplished by inserting catheters into the blood system or to use an implanted bloodstream access device which may be connected to an artificial kidney. Such devices may be used repeatedly for numerous treatments.
  • a device for filtering blood including a filter unit having a blood filter, an inlet for blood to be filtered and being connectable to an artery of a patient and a blood outlet for filtered blood and being connectable to a vein of the patient, and having a filtrate container for receiving filtrate passing through the blood filter during a filtering process and that the filtrate container is a closed container which in a filled state is arranged to establish a counter-pressure over the blood filter, whereby the filtering process is interrupted characterized in that the filtrate container encloses the filter unit.
  • the device is simple to make portable so as to be capable of being conveniently used outside a dialysis site. Patients could therefore without any difficulty be trained to use it, for example, in the homes, and still be movable. This allows the patients to attend also to other tasks, such as cooking, cleaning etc., without being restricted to stay in bed or be tied to a specific, stationary apparatus for a substantial time during the treatment.
  • a filtrate container which encloses the filter unit simplifies production and handling of the device as well as the process for its use in practice.
  • the device comprises an integral unit which is being disposable after use.
  • FIG. 1 shows a system according to the invention carried by a patient
  • FIG. 2 shows a device for filtering blood included in the system of FIG. 1 .
  • FIGS. 3 and 4 show alternative embodiments of the device according to the invention.
  • a dialysis patient 1 suffering from renal failure conditions carries an implanted bloodstream access device 2 which is connected over connection houses 3 , 4 to a blood filtering device 5 .
  • the bloodstream access device 2 is preferably an implanted device, as the one disclosed in WO 99/20338 (Danielson et. al.).
  • Such an access device is marketed under the trade mark Hemaport® 605. That device provides a considerable pressure difference between the artery and the vein side so as to drive a continuous flow of blood through an external circuit. Also other blood access devices providing sufficient pressure difference may be used together with the invention.
  • vascular grafts and fistulas which are commonly used for gaining access to a patient's bloodstream do not provide sufficient pressure difference for driving the blood through a blood filtering device according to the invention.
  • the blood filtering device includes a rigid container which is carried by the patient 1 with the aid of a fastening strap 16 .
  • the blood filtering device 5 is shown in greater detail in FIG. 2 .
  • the device 5 is shown including a filtrate container 6 which at its upper portion contains a filter unit 7 .
  • the filter unit is comprised of a substantially tubular, hollow ultra filtration filter having closed ends in inlet and outlet regions of the filter unit 7 .
  • An inlet connection hose 4 is connected to an inlet nipple 8 leading in to the interior of the filter unit 7 .
  • an outlet nipple 9 connects with an outlet connection hose 3 .
  • the inlet and outlet connection hoses 4 and 3 are connected to the respective artery and vein side of the bloodstream access device 2 ( FIG. 1 ).
  • the inlet and outlet nipples 8 , 9 also contribute to positioning the filter unit 7 with respect to the filtrate container 6 by being engaged in through-holes (not shown) in the wall of the container.
  • the remaining components of the blood are discharged through the outlet nipple 9 over the connection hose 3 so as to be brought back into the bloodstream of the patient over the bloodstream access device ( FIG. 1 ).
  • the properties of the filter of the filter unit 7 is chosen in such a way that an appropriate amount of said liquid component is filtered out as filtrate. This could be easily tested for for example ultra filtration filters and choosing a suitable filter area for chosen material properties so as to apply to certain conditions and applications of use.
  • a condition to consider is the body weight of a patient.
  • the filtrate container 6 is a rigid or semi-rigid container, gas or air being present inside the filtrate container must be allowed to escape therefrom so as to leave room for the filtrate. For that reason at least one air vent 10 is provided at an appropriate position at the top region of the filtrate container 6 .
  • the air vent 10 includes a membrane which is air or gas permeable and liquid impermeable so that no liquid leakage will occur through the air vent 10 while gas may escape.
  • a membrane which is air or gas permeable and liquid impermeable so that no liquid leakage will occur through the air vent 10 while gas may escape.
  • Other solutions such as liquid controlled flap-valves or the like are also possible to use, in order to allow air to escape from the filtrate container but liquid to remain inside.
  • the filtrate container 6 may come in different volumes, for example having between 0.2 to 1 litre volume, depending on such conditions as for example body weight of the patient and also which amount of liquid that is desired to withdraw from the patient at the specific occasion.
  • the filtrate container 6 is at least translucent, allowing a visual indication of the level 13 of filtrate 12 inside the container.
  • the container may also have a scale 11 readable against the filtrate level 13 .
  • the filtrate container 6 when a desired amount of filtrate is withdrawn from the bloodstream the filtrate container 6 will be completely filled with that amount of filtrate. This will result in that the filtering operation of the filter unit 7 is interrupted because a counter-pressure will be established over the filter wall of the filter unit. This in turn results in that all blood entering the filter unit 7 through the inlet nipple also will flow through the outlet nipple 9 . From there it will be fed back into the bloodstream through the outlet connection hose 3 and the bloodstream access device 2 ( FIG. 1 ).
  • a counter-pressure over the blood filter will be established when the filtrate 12 reaches a filtrate level over the air vent 10 , thereby trapping air between the filtrate level 13 and the filter unit 7 . This may create a sufficient counter-pressure over the wall of the filter for the filter action be terminated.
  • a filtrate container 14 is shown being a flexible, collapsible pouch type filtrate container.
  • a counter-pressure of a magnitude being sufficient for the filter action to be terminated will be established when the pouch comprising the filtrate container 14 reaches such an expanded state that further expansion is impossible with the pressure available through the wall of the filter unit 7 .
  • the filter unit is placed inside the filtrate container 14 .
  • FIG. 4 shows a further embodiment, wherein a filtrate container 14 , substantially like the one described in connection with FIG. 3 , is contained inside a rigid outer container 15 .
  • That outer container 15 must not be liquid tight but may only be intended to protect the flexible container and possibly to provide a volume restriction thereof.
  • connection lid which is intended to co-operate with the bloodstream access device 2 ( FIG. 1 ).
  • a connection lid may be of a kind described in the above mentioned WO 99/20338.
  • Filter materials for use in the filter units shall be of the kind normally used for filtration of blood such as ultra filtration filters.
  • the invention is described for filtering a liquid component from a patient's blood. That liquid component may, however, include also certain solid substances.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

Device (5) for filtering blood including a filter unit (7) having a blood filter, an inlet (8) for blood to be filtered and being connectable to an artery of a patient and a blood outlet (9) for filtered blood and being connectable to a vein of the patient, and having a filtrate container (6,14), that encloses the filter unit (7), for receiving filtrate (12) passing through the blood filter during a filtering process and that the filtrate container (6,14) is a closed container, which in a filled state is arranged to establish a counter-pressure over the blood filter, whereby the filtering process is interrupted. The invention also concerns a system including the above device.

Description

This is a Continuation application of application Ser. No. 10/514,634, filed Feb. 17, 2005, which is a nationalization application of PCT/SE03/00783 filed May 14, 2003, published in English, which claims benefit of Sweden Application 0201496-7filed May 17, 2002.
FIELD OF THE INVENTION
The invention concerns a device for filtering blood. The invention also concerns a system for ultra filtration of blood including such a device.
DESCRIPTION OF PRIOR ART
It is previously known to treat patients having chronic renal failure with hemodialysis. Hemodialysis treatments are traditionally carried out about three times a week, whereby the blood is purified and the liquid balance is adjusted at a hemodialysis site in a hospital.
One condition for hemodialysis is the establishment of a connection to the patient's bloodstream having a sufficience flow. This may be accomplished by inserting catheters into the blood system or to use an implanted bloodstream access device which may be connected to an artificial kidney. Such devices may be used repeatedly for numerous treatments.
Since the kidneys of a patient suffering from renal conditions usually do not produce any urine, the patient normally turns up at the hemodialysis site with an excess of liquid in the body. After the hemodialysis treatment this has been changed to a shortage of liquid in the body. These fluctuating fluid levels may cause serious health problems besides the conditions that the patients are treated for.
AIM AND MOST IMPORTANT FEATURES OF THE INVENTION
It is an aim of this invention to provide a solution to the above problem and in particular to suggest a simple, economic and effective solution allowing better control of the liquid balance for dialysis patients having a chronic renal failure diagnosis.
The aim is achieved with a device for filtering blood including a filter unit having a blood filter, an inlet for blood to be filtered and being connectable to an artery of a patient and a blood outlet for filtered blood and being connectable to a vein of the patient, and having a filtrate container for receiving filtrate passing through the blood filter during a filtering process and that the filtrate container is a closed container which in a filled state is arranged to establish a counter-pressure over the blood filter, whereby the filtering process is interrupted characterized in that the filtrate container encloses the filter unit.
This way it is possible to effectively filter out a desired, predetermined amount of liquid from the blood of the patient between the ordinary hemodialysis treatments. This brings about great advantages for the patients, since it provides important opportunities to better control the liquid balance between the treatments, whereby the liquid level is allowed to be equalised over time. This measure can radically reduce strain on the patient's body caused by fluctuating liquid levels.
The device is simple to make portable so as to be capable of being conveniently used outside a dialysis site. Patients could therefore without any difficulty be trained to use it, for example, in the homes, and still be movable. This allows the patients to attend also to other tasks, such as cooking, cleaning etc., without being restricted to stay in bed or be tied to a specific, stationary apparatus for a substantial time during the treatment. In particular, the provision of a filtrate container which encloses the filter unit simplifies production and handling of the device as well as the process for its use in practice.
Providing a substantially rigid vessel for collecting filtrate and having an air vent therein, allows production and provision of a robust device which can be easily handled in virtually any environment.
Providing a flexible expandable container, which is collapsible in an empty state, as the filtrate container, simplifies transport, storage and related handling.
Production, handling and use is further enhanced when the device comprises an integral unit which is being disposable after use.
Further advantages are obtained with other aspects of the invention. Such aspects are subject to dependent claims and will become apparent from the following description of embodiments.
BRIEF DESCRIPTION OF THE DRAWINGS
The invention is now described in greater detail at the background of an embodiment and with reference to the annexed drawings, wherein:
FIG. 1 shows a system according to the invention carried by a patient,
FIG. 2 shows a device for filtering blood included in the system of FIG. 1, and
FIGS. 3 and 4 show alternative embodiments of the device according to the invention.
 DESCRIPTION OF A PREFERRED EMBODIMENT
In FIG. 1 a dialysis patient 1 suffering from renal failure conditions carries an implanted bloodstream access device 2 which is connected over connection houses 3, 4 to a blood filtering device 5. The bloodstream access device 2 is preferably an implanted device, as the one disclosed in WO 99/20338 (Danielson et. al.).
Such an access device is marketed under the trade mark Hemaport® 605. That device provides a considerable pressure difference between the artery and the vein side so as to drive a continuous flow of blood through an external circuit. Also other blood access devices providing sufficient pressure difference may be used together with the invention.
In this connection it could be mentioned that vascular grafts and fistulas which are commonly used for gaining access to a patient's bloodstream do not provide sufficient pressure difference for driving the blood through a blood filtering device according to the invention.
In the case illustrated in FIG. 1, the blood filtering device includes a rigid container which is carried by the patient 1 with the aid of a fastening strap 16.
The blood filtering device 5 is shown in greater detail in FIG. 2. Here the device 5 is shown including a filtrate container 6 which at its upper portion contains a filter unit 7. The filter unit is comprised of a substantially tubular, hollow ultra filtration filter having closed ends in inlet and outlet regions of the filter unit 7. An inlet connection hose 4 is connected to an inlet nipple 8 leading in to the interior of the filter unit 7.
At the outlet end of the filter unit 7, an outlet nipple 9 connects with an outlet connection hose 3. The inlet and outlet connection hoses 4 and 3 are connected to the respective artery and vein side of the bloodstream access device 2 (FIG. 1). The inlet and outlet nipples 8, 9 also contribute to positioning the filter unit 7 with respect to the filtrate container 6 by being engaged in through-holes (not shown) in the wall of the container.
In use of the device 5, blood flows from inlet nipple 8 through the filter unit 7, where a portion of the liquid component of the blood is filtered out as filtrate through the filter wall of the filter unit 7 so as to be collected inside the filtrate container 6. The remaining components of the blood are discharged through the outlet nipple 9 over the connection hose 3 so as to be brought back into the bloodstream of the patient over the bloodstream access device (FIG. 1).
The properties of the filter of the filter unit 7 is chosen in such a way that an appropriate amount of said liquid component is filtered out as filtrate. This could be easily tested for for example ultra filtration filters and choosing a suitable filter area for chosen material properties so as to apply to certain conditions and applications of use. One example of a condition to consider is the body weight of a patient.
In case the filtrate container 6 is a rigid or semi-rigid container, gas or air being present inside the filtrate container must be allowed to escape therefrom so as to leave room for the filtrate. For that reason at least one air vent 10 is provided at an appropriate position at the top region of the filtrate container 6.
Preferably the air vent 10 includes a membrane which is air or gas permeable and liquid impermeable so that no liquid leakage will occur through the air vent 10 while gas may escape. Other solutions such as liquid controlled flap-valves or the like are also possible to use, in order to allow air to escape from the filtrate container but liquid to remain inside.
The filtrate container 6 may come in different volumes, for example having between 0.2 to 1 litre volume, depending on such conditions as for example body weight of the patient and also which amount of liquid that is desired to withdraw from the patient at the specific occasion.
Preferably the filtrate container 6 is at least translucent, allowing a visual indication of the level 13 of filtrate 12 inside the container. The container may also have a scale 11 readable against the filtrate level 13.
According to the invention, when a desired amount of filtrate is withdrawn from the bloodstream the filtrate container 6 will be completely filled with that amount of filtrate. This will result in that the filtering operation of the filter unit 7 is interrupted because a counter-pressure will be established over the filter wall of the filter unit. This in turn results in that all blood entering the filter unit 7 through the inlet nipple also will flow through the outlet nipple 9. From there it will be fed back into the bloodstream through the outlet connection hose 3 and the bloodstream access device 2 (FIG. 1).
As an alternative, is possible that a counter-pressure over the blood filter will be established when the filtrate 12 reaches a filtrate level over the air vent 10, thereby trapping air between the filtrate level 13 and the filter unit 7. This may create a sufficient counter-pressure over the wall of the filter for the filter action be terminated.
In FIG. 3 a filtrate container 14 is shown being a flexible, collapsible pouch type filtrate container. In this case a counter-pressure of a magnitude being sufficient for the filter action to be terminated will be established when the pouch comprising the filtrate container 14 reaches such an expanded state that further expansion is impossible with the pressure available through the wall of the filter unit 7. Also in this case the filter unit is placed inside the filtrate container 14.
FIG. 4 shows a further embodiment, wherein a filtrate container 14, substantially like the one described in connection with FIG. 3, is contained inside a rigid outer container 15. That outer container 15 must not be liquid tight but may only be intended to protect the flexible container and possibly to provide a volume restriction thereof.
It is highly preferred that all parts of the system for blood filtering are disposable after use, including the filtrate container, the filter unit, the connection hoses and also a connection lid which is intended to co-operate with the bloodstream access device 2 (FIG. 1). Such a connection lid may be of a kind described in the above mentioned WO 99/20338.
Materials for use in elements comprising the invention must fulfil normal requirements for medical purposes. Filter materials for use in the filter units shall be of the kind normally used for filtration of blood such as ultra filtration filters.
The invention is described for filtering a liquid component from a patient's blood. That liquid component may, however, include also certain solid substances.

Claims (8)

The invention claimed is:
1. A device for filtering blood comprising:
a filter unit having an inlet for blood to be filtered and being connectable to an artery of a patient and a blood outlet for filtered blood and being connectable to a vein of the patient, and
a filtrate container for receiving a filtrate filtered from the blood passing through the filter unit during a filtering process, said filtrate container enclosing the filter unit,
the filtrate container being a closed container which, during the filtering provides room for filtrate received through walls of the filtering unit and, the filtrate container in a filled state, establishing a counter-pressure over the walls of the filter unit so that the filtering process is interrupted, wherein the filtrate container includes a flexible, expandable container which is collapsed in an empty state.
2. The device according to claim 1, wherein the flexible, expandable container is enclosed in an outer, substantially rigid container.
3. The device according to claim 1, wherein the filtrate container with the filter unit is a one-way, disposable unit.
4. The device according to claim 1, wherein the filter unit comprises a substantially tubular filter body.
5. The device according to claim 1, wherein the filter unit is an ultra filtration filter.
6. The device according to claim 1, wherein a filtrate volume of the filtrate container is chosen between about 0.2-1 liter.
7. A system for ultra filtration of blood including a device according to claim 1.
8. The system according to claim 7 further including an implanted bloodstream access device.
US13/347,074 2002-05-17 2012-01-10 Device and system for filtering blood Expired - Fee Related US8617392B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/347,074 US8617392B2 (en) 2002-05-17 2012-01-10 Device and system for filtering blood
US14/096,774 US8852433B2 (en) 2002-05-17 2013-12-04 Device and system for filtering blood

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
SE0201496 2002-05-17
SE0201496-7 2002-05-17
SE0201496A SE522048C2 (en) 2002-05-17 2002-05-17 Blood filtration device and system
PCT/SE2003/000783 WO2003097130A1 (en) 2002-05-17 2003-05-14 Device and system for filtering blood
US10/514,634 US8153008B2 (en) 2002-05-17 2003-05-14 Device and method for filtering blood
US13/347,074 US8617392B2 (en) 2002-05-17 2012-01-10 Device and system for filtering blood

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
US10514634 Continuation 2003-05-14
PCT/SE2003/000783 Continuation WO2003097130A1 (en) 2002-05-17 2003-05-14 Device and system for filtering blood
US10/514,634 Continuation US8153008B2 (en) 2002-05-17 2003-05-14 Device and method for filtering blood

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/096,774 Continuation US8852433B2 (en) 2002-05-17 2013-12-04 Device and system for filtering blood

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US20120116283A1 US20120116283A1 (en) 2012-05-10
US8617392B2 true US8617392B2 (en) 2013-12-31

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US13/347,074 Expired - Fee Related US8617392B2 (en) 2002-05-17 2012-01-10 Device and system for filtering blood
US14/096,774 Expired - Fee Related US8852433B2 (en) 2002-05-17 2013-12-04 Device and system for filtering blood

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US (3) US8153008B2 (en)
EP (1) EP1509262B1 (en)
JP (2) JP4727983B2 (en)
AT (1) ATE367839T1 (en)
AU (1) AU2003232702A1 (en)
DE (1) DE60315155T2 (en)
ES (1) ES2287513T3 (en)
SE (1) SE522048C2 (en)
WO (1) WO2003097130A1 (en)

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AU2008345218B2 (en) 2007-12-28 2015-02-19 Takeda Pharmaceutical Company Limited Counter-pressure filtration of proteins
ES2625135T3 (en) 2010-07-05 2017-07-18 Gambro Lundia Ab An ambulatory ultrafiltration device, related methods and a computer program product
US9907570B2 (en) 2013-08-23 2018-03-06 Oscor Inc. Steerable medical devices
MA39440A1 (en) * 2016-11-07 2018-05-31 Univ Hassan Ii De Casablanca Portable ultrafiltration device
WO2020176879A1 (en) * 2019-02-28 2020-09-03 Qidni Labs Inc. Systems and methods of gas removal from a wearable device
US11266825B2 (en) 2020-02-20 2022-03-08 First Pass, Llc Manual clot aspiration and filtration system and method of removing a clot

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US3388803A (en) 1965-04-16 1968-06-18 Applied Biolog Sciences Lab In Wearable dialysis apparatus
US3884808A (en) 1973-06-20 1975-05-20 Res Dev Systems Inc Wearable, self-regenerating dialysis appliance
US4071444A (en) 1976-10-12 1978-01-31 Purdue Research Foundation Portable chemical reactor for use as an artificial kidney
US4235233A (en) 1977-05-04 1980-11-25 Johnson & Johnson Bag for collecting, storing and administering including filtering blood, blood components, intravenous fluids and similar fluids
US4275732A (en) 1977-08-19 1981-06-30 Gereg Gordon A Suction canister with membrane shut-off valve
GB2052948A (en) 1979-06-22 1981-02-04 Biotest Serum Institut Gmbh Apparatus for conserving blood or plasma
JPS5875558A (en) 1981-10-31 1983-05-07 住友ベークライト株式会社 Mountable artificial kidney
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US20120116283A1 (en) 2012-05-10
JP2010221058A (en) 2010-10-07
ES2287513T3 (en) 2007-12-16
JP4727983B2 (en) 2011-07-20
EP1509262A1 (en) 2005-03-02
US20140091018A1 (en) 2014-04-03
US20050126962A1 (en) 2005-06-16
JP2005525878A (en) 2005-09-02
SE522048C2 (en) 2004-01-07
AU2003232702A1 (en) 2003-12-02
DE60315155D1 (en) 2007-09-06
US8153008B2 (en) 2012-04-10
WO2003097130A1 (en) 2003-11-27
DE60315155T2 (en) 2008-05-15
SE0201496D0 (en) 2002-05-17
ATE367839T1 (en) 2007-08-15
SE0201496L (en) 2003-11-18
US8852433B2 (en) 2014-10-07
EP1509262B1 (en) 2007-07-25

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