Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Definitions

• This invention relates to a method for prophylactically treating dairy cattle for parturient paresis using a mixture of 25-hydroxycholecalciferol and 1 ⁇ -hydroxycholecalciferol.
• Parturient paresis is a metabolic disease of dairy cows wherein severe hypocalcemia, resulting from parturition and the initial formation of milk, leads to a disorder characterized by the cow's inability to command use of their muscles and a placid, immobile appearance.
• the disease is manifested by a decrease in plasma calcium, usually between six to thirty hours after parturition, to a value so low as to induce tetany with resultant immobilization of the cow.
• the blood phosphate level is about 10 mg./100 ml. (or 10 mg. percent). Following parturition this level will normally dip to about 7-8 mg. percent but will then rise in a reasonable time to the more normal 10 mg. percent range.
• the plasma calcium may dip more drastically, such as into the 5 mg. percent range, and it is recognized that at such plasma calcium levels the cow can go into tetany and a condition known as Downer's Syndrome.
• milk fever disease has been estimated to be in the range from about 3.5-5% of the world's dairy cows. In individual herds, however, the incidence may be as high as 60-70%. It appears that the incidence of the disease is highest among high milk producing cows during the third and later lactation periods although at times it has been observed in the second lactation period. In any event, once a cow has had milk fever there is an 80-90% probability that she will again be so afflicted after her next parturition. As a consequence, there has been much interest in developing procedures for preventing this disorder.
• the cow is fed 20 million units per day of vitamin D for three to seven days before calving while in another method 10 million units of vitamin D is injected intramuscularly before calving.
• these methods are of value they are associated with potentially high risk and other disadvantages.
• administration of such large dosages of vitamin D there is a real danger of vitamin D toxicity and, as a consequence, death of the cow or damage through abnormal calcification of the soft tissues such as the kidney, aorta, etc.
• 25-hydroxyvitamin D 3 (25-OH-D 3 ) can markedly reduce the incidence of parturient paresis will be evident from the following table although it should also be observed that 25-OH-D 3 does not eliminate or totally prevent the disorder.
• the preferred dose would be 4 mg. of 25-OH-D 3 to achieve the lowest incidence of the disease.
• 1 ⁇ -hydroxycholecalciferol (1 ⁇ -OH-D 3 ) is also capable of reducing the incidence of parturient paresis as will be evident from the following table.
• Effective and practical administration of the combination of 25-OH-D 3 and 1 ⁇ -OH-D 3 can be accomplished by injection of the material intravenously, intramuscularly or subcutaneously while dissolved in a suitable vehicle such as an innocuous oil or propylene glycol.
• a suitable vehicle such as an innocuous oil or propylene glycol.
• the combination of 25-OH-D 3 and 1 ⁇ -OH-D 3 can be compounded with other materials to form a bolus, or can be encapsulated, so that oral administration can be the preferred route of administration.
• the materials can be applied topically in a suitable vehicle and perhaps in the presence of an agent e.g. dimethyl-sulfoxide, which enhances penetration of the skin.
• the dosages in the foregoing Example are effective in providing total protection against parturient paresis
• the particular dosages, or ratios of 25-OH-D 3 to 1 ⁇ -OH-D 3 specified are not necessarily critical, other dosages, as well as ratios, of the combination of these compounds being equally effective. Dosage can, of course, vary with the size of the cow to which it is being administered. In any event, sufficient of the combination in effective ratios of one to the other must be given to accomplish the desired end, namely, complete protection against the incidence of parturient paresis. The use of more than sufficient material to accomplish such end should be avoided as an economically unsound practice.

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• Health & Medical Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Medicinal Chemistry (AREA)
• Pharmacology & Pharmacy (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Epidemiology (AREA)
• Engineering & Computer Science (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Endocrinology (AREA)
• Reproductive Health (AREA)
• Chemical Kinetics & Catalysis (AREA)
• General Chemical & Material Sciences (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Organic Chemistry (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
• Fodder In General (AREA)
• Medicinal Preparation (AREA)

Priority Applications (12)

Applications Claiming Priority (1)

Publications (1)

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Cited By (10)

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Citations (2)

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• 1981
  • 1981-05-11 US US06/262,093 patent/US4338312A/en not_active Expired - Fee Related
• 1982
  • 1982-05-06 CA CA000402445A patent/CA1187794A/fr not_active Expired
  • 1982-05-07 NL NL8220210A patent/NL8220210A/nl not_active Application Discontinuation
  • 1982-05-07 WO PCT/US1982/000602 patent/WO1982004051A1/fr active Application Filing
  • 1982-05-07 JP JP57501922A patent/JPS58500665A/ja active Granted
  • 1982-05-07 AU AU85818/82A patent/AU549959B2/en not_active Ceased
  • 1982-05-10 FR FR8208110A patent/FR2505184B1/fr not_active Expired
  • 1982-05-10 GB GB8213484A patent/GB2098066B/en not_active Expired
  • 1982-05-10 BE BE0/208056A patent/BE893136A/fr not_active IP Right Cessation
  • 1982-05-11 IE IE1131/82A patent/IE53147B1/en unknown
  • 1982-05-11 IL IL65744A patent/IL65744A/xx unknown

Patent Citations (2)

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