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US3917063A - Packages enabling the extemporaneous preparation of suspensions or sterile solutions - Google Patents

Packages enabling the extemporaneous preparation of suspensions or sterile solutions Download PDF

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Publication number
US3917063A
US3917063A US36743773A US3917063A US 3917063 A US3917063 A US 3917063A US 36743773 A US36743773 A US 36743773A US 3917063 A US3917063 A US 3917063A
Authority
US
United States
Prior art keywords
flask
package
flasks
set forth
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
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English (en)
Inventor
Jean Chibret
Charles Manni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEmballage et de Conditionnement SEMCO SAM
Original Assignee
Societe dEmballage et de Conditionnement SEMCO SAM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe dEmballage et de Conditionnement SEMCO SAM filed Critical Societe dEmballage et de Conditionnement SEMCO SAM
Application granted granted Critical
Publication of US3917063A publication Critical patent/US3917063A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D55/00—Accessories for container closures not otherwise provided for
    • B65D55/02—Locking devices; Means for discouraging or indicating unauthorised opening or removal of closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
    • B65D81/3211—Separate rigid or semi-rigid containers joined to each other at their external surfaces coaxially and provided with means facilitating admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/08—Mixing

Definitions

  • a package for the extemporaneous preparation of suspensions or sterile solutions comprises two flasks at least one of which is of a flexible material and which are adapted respectively to contain one a liquid and the other a solid product to be dissolved in or put into suspension in the liquid at the time of use.
  • Each flask has associated therewith stopper means and the package includes means for temporarily putting the flask interiors into communication with one another through at least-one part of said stopper means.
  • Said at least one of the flasks is manually deformable to effect the passage of the liquid from its flask into the flask containing'the solid product, and the return into said at least one of said flasks of the resultant solution or suspension.
  • FIG l PACKAGES ENABLING THE EXTEMPORANEOUS PREPARATION OF SUSPENSIONS OR STERILE SOLUTIONS
  • This invention relates to packagesenabling the extemporaneous preparation of suspensions or sterile solutions.
  • the primary object of the invention is to simplify these preparations while paying proper regard to the usual conditions of asepsis.
  • the present invention is a package comprising two flasks of which at least one is of a flexible material and which are adapted to contain one a liquid and the other a solid product to be dissolved in or put into suspension in said liquid at the time of use, stopper means on each flask and means for temporarily putting the interiors of the two flasks into communication with one another through at least one part of said stopper means, and in which the passage of the liquid from its flask to that of the solid product and the return of the solution or of the suspension to the flask for the liquid may be effected by manual deformation of at least one of the flasks.
  • This package enables there to be obtained a preparation the sterility of which is perfectly maintained both in use and in keeping in stock.
  • the stopper means on one of the flasks makes up at least partially a device for perforating the stopper means on the other flask.
  • FIG. 1 is a sectional elevation ofa package according to a first embodiment of the invention, in the condition before the two flasks have been put into communication with one another;
  • FIG. 2 is an exploded sectional elevation of the package shown in FIG. 1;
  • FIG. 3 is a sectional elevation ofa package according to a second embodiment of the invention in the condition before the two flasks have been put into communication with one another;
  • FIG. 4 is a sectional elevation of a package according to a third embodiment of the invention in the condition after the two flasks have been put into communication with one another;
  • FIG. 5 is an exploded sectional elevation of the package shown in FIG. 4, the stopper means and the cover being in the condition before the two flasks have been put into communication with one another;
  • FIG. 6 is a sectional elevation of a modified plug for the package shown in FIGS. 4 and 5.
  • the package of FIGS. 1 and 2 is made up mainly by two flasks l and 2, the flask 1 containing a liquid and the flask 2 containing a solid product.
  • the flask l at least is of a flexible material.
  • the flask 2 is stopped by a plug 3 of elastomeric material provided with a blind hole 4 located below a membrane 5.
  • a ball 6 is held captive resiliently in the plug 3.
  • a washer 7 which is impervious to the liquid in the flask 1 and is formed by a polyethylene disk coated on one of its faces with a film of aluminium.
  • the washer 7 itself has thereabove an internallythreaded tubular casing 8, held in place on the plug 3 with the said washer by a collar 9 flanged around and taking support on the rim of the neck of the bottle 2.
  • the flask 1 is stopped by a dropper 10 the position of which in the neck of the bottle 1 is limited by a shoulder 11.
  • the flask l is screwed by a thread 12 around its neck into the internally-threaded tubular casing 8.
  • the end of the dropper 10 which is open, rests on the impervious washer 7 and the relative position of the flask 1 dropper l0 assembly with respect to the flask 2 and to the parts which are united therewith is ensured by a tearable or rupturable spacing ring 13 accommodated in a peripheral space between a peripheral external flange 20 around the neck of the flask l, and the adjacent end of the tubular casing 8.
  • the spacing ring 13 supports a removable cover 14 which can subsequently be used for covering and protecting the lesser diameter end of the dropper 10.
  • FIGS. 1 and 2 The package of FIGS. 1 and 2 is used as follows:
  • the flask 1 is screwed into. the tubular casing 8, this occasioning successively puncturings of the washer 7 and of the membrane 5 by the end of the dropper l0 7 and the dropping into the flask of the ball 6 expelled from its seat,
  • the solution or the desired suspension is obtained.
  • the ball 6 then plays the part of an agitator in the flask 2 and speeds up the obtaining of the preparation,
  • the package is then inverted and the preparation sucked into the flask l, which is thereafter separated (with its dropper 10) from the flask 2.
  • the dropper 10 is covered by the cover 14 detached from the spacer ring 13.
  • the package of FIG. 3 includes two flasks 1a and 2a whereof the former holds a perforating dropper 10a and the latter a plug 3a with a ball 6a, an impervious washer7a and an encasing ring 9a.
  • the initial positioning of the flasks la and 2a is ensuredby a spacing ring 15 whichit isnecessary to tear inorder to enable successively the perforation of the washer 7a and that of the membrane 50 aswell as the dropping of the ball 6a into the receptacle 2a and the stepspof transferring the products, such as have been described with reference to FlGS. l and 2.
  • the packageofFlGS. 4 and is made upmainly of.
  • the flask 2b is stopped by a plug 3b with a perferable membrane Shanda cover 17 kept on the flask 2b an encasing ring 9b.
  • the cover 17 includes a hemispherical central part 18 which can be cut off just as can the bulged part.16 of the dropper.
  • the flasks 1b and 2b are initially sepa- 7 rated.
  • the bulged part 1 6 of the dropper 10b' and thehemispherical central part 18 of the cover 17 are cutoff along the respective dot-dash lines'x and y indic ated in FIGS.
  • the extremity of the dropper 10b is then introduced into the remaining part of the cover 17, which ensures guidance of the dropper, and 'the latter pierces the perforable membrane 5b of the plug 3b.
  • the package then being in the condition shown in FIG. 4, it is possible to proceed with the trans-1 fer of the liquid and then the preparation by dcforma tions under consideration; without thereby departing from the scope of the invention defined in the claims.
  • a package comprising two flasks of which at least one is of a flexible material and which are adapted to contain one a liquid and the other a solid product which is a'se'lected member of thegroup consisting of substances dissol'vable in and'substances suspendible in said liquid at the time of use, stopper means on each flask and means fortemporarily putting the interiors of the two flasks into communication with one another through at least one part of said stopper means, said at least one of the flasks being manually deformable to effeet the passage ofthe liquid fromits flask into that of the solid product and the return of the solution or of the suspension tothe flask for the liquid, said flasks are kept together in alignment and in readiness for the putting of their contents into communication with each other by spacing means which can be torn away- 2.
  • the stopper means on one of the flasks makes up at least partially a device for perforating the stopper means on the other
  • stopper means of said other of the flasks comprises a plug of'elastomeric material held in the neck of the flask and having an axial bore stopped by means which canbe overcome by said dropper projecting end.
  • a package as set forthv in claim 4, in which said means which can be overcome consists of an ejectable ball and a perforable membrane.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)
US36743773 1972-06-13 1973-06-06 Packages enabling the extemporaneous preparation of suspensions or sterile solutions Expired - Lifetime US3917063A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7221179A FR2188565A5 (fr) 1972-06-13 1972-06-13

Publications (1)

Publication Number Publication Date
US3917063A true US3917063A (en) 1975-11-04

Family

ID=9100094

Family Applications (1)

Application Number Title Priority Date Filing Date
US36743773 Expired - Lifetime US3917063A (en) 1972-06-13 1973-06-06 Packages enabling the extemporaneous preparation of suspensions or sterile solutions

Country Status (6)

Country Link
US (1) US3917063A (fr)
BE (1) BE800782A (fr)
DE (1) DE2329704A1 (fr)
FR (2) FR2188565A5 (fr)
IT (1) IT989075B (fr)
LU (1) LU67780A1 (fr)

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559983A (en) * 1982-12-29 1985-12-24 Laboratoires Merck Sharp & Dohme Chibret Device for preparing and dispensing a solution
US4573506A (en) * 1983-09-26 1986-03-04 Laboratories Merck Sharp & Dohme - Chibret Two-bottle assembly for preparing and dispensing a solution
US4591049A (en) * 1984-01-16 1986-05-27 Kidde, Inc. Hermetically sealed two-component mixing system
EP0246835A2 (fr) * 1986-05-21 1987-11-25 Johnsen & Jorgensen Jaypak Limited Systèmes et appareils pour mélanger des produits
US4858759A (en) * 1985-12-21 1989-08-22 Hilti Aktiengesellschaft Container arrangement for cartridge dispensing two-component mass
US4936446A (en) * 1988-03-02 1990-06-26 Laboratoires Merck, Sharp & Dohme-Chibret Packaging and dispensing system for packaging two ingredients separately and mixing them extemporaneously at the time of first use, and method of assembling same
US4986322A (en) * 1987-03-24 1991-01-22 Societe Semco System of packaging for ready to use preparations
EP0503867A2 (fr) * 1991-03-08 1992-09-16 Material Engineering Technology Laboratory, Inc. Obturateur pour récipient, et dispositif de stockage et de mélange
US5207320A (en) * 1989-05-24 1993-05-04 Allen Nicholas J Compartmented mixing device with bead
US5209565A (en) * 1991-12-20 1993-05-11 L'oreal Assembly adapted for the mixing of two different products stored separately
US5257650A (en) * 1989-06-02 1993-11-02 Abbott Laboratories Two-piece reagent container assembly
US5342347A (en) * 1991-08-29 1994-08-30 Nissho Corporation Drug container and dual container system for fluid therapy employing the same
US5342346A (en) * 1992-04-10 1994-08-30 Nissho Corporation Fluid container
US5380315A (en) * 1992-02-04 1995-01-10 Material Engineering Technology Laboratory Incorporated Mixing apparatus
US5409141A (en) * 1992-03-13 1995-04-25 Nissho Corporation Two component mixing and delivery system
US5454409A (en) * 1991-02-15 1995-10-03 Waverly Pharmaceutical, Ltd. Transfer adaptors
US5465768A (en) * 1994-03-01 1995-11-14 Deroos; Bradley G. Fluid transport container
US5893484A (en) * 1995-07-14 1999-04-13 Ing. Erich Pfeiffer Gmbh Discharge device for fluid media, particularly for single-stroke only discharge
US6022339A (en) * 1998-09-15 2000-02-08 Baxter International Inc. Sliding reconstitution device for a diluent container
EP0945364A3 (fr) * 1998-03-23 2000-03-01 Wella Aktiengesellschaft Récipient pour produit à deux composants
US6063068A (en) * 1997-12-04 2000-05-16 Baxter International Inc. Vial connecting device for a sliding reconstitution device with seal
US6126032A (en) * 1998-03-23 2000-10-03 Wella Aktiengesellschaft Two-component container
US6164501A (en) * 1996-02-08 2000-12-26 Tebro Device for dispensing a fluid contained in a hermetically closed container
AU732164B2 (en) * 1997-01-24 2001-04-12 Diagnostica Stago Seal for reagent flask usable by a blood analyser
US6237649B1 (en) * 1997-08-27 2001-05-29 Pentapharm Ag Dual vial connecting system for lyophilized products
US6582415B1 (en) 1998-09-15 2003-06-24 Thomas A. Fowles Sliding reconstitution device for a diluent container
US20040050885A1 (en) * 2000-12-08 2004-03-18 Giuseppe Stradella Fluid or powdery product dispensing device
US20050088496A1 (en) * 2003-10-22 2005-04-28 Lui Pui K. Ink refilling cap
US20050238408A1 (en) * 2004-01-20 2005-10-27 L'oreal Kit comprising two receptacles and an applicator
US7074216B2 (en) 1998-09-15 2006-07-11 Baxter International Inc. Sliding reconstitution device for a diluent container
US20070224089A1 (en) * 2006-03-23 2007-09-27 Logan Thomas M Sample tube and vial processing system, and method for processing the sample
US7358505B2 (en) 1998-09-15 2008-04-15 Baxter International Inc. Apparatus for fabricating a reconstitution assembly
US7425209B2 (en) 1998-09-15 2008-09-16 Baxter International Inc. Sliding reconstitution device for a diluent container
US7641851B2 (en) 2003-12-23 2010-01-05 Baxter International Inc. Method and apparatus for validation of sterilization process
US20130079756A1 (en) * 2011-09-23 2013-03-28 Adapta Medical, Inc. Catheter Reservoir Seal
CN105857890A (zh) * 2016-06-06 2016-08-17 洛阳海惠新材料股份有限公司 一种乙二醇锑的包装容器
US10238803B2 (en) 2016-05-02 2019-03-26 Sun Pharmaceutical Industries Limited Drug delivery device for pharmaceutical compositions
US10258583B2 (en) 2014-05-01 2019-04-16 Sun Pharmaceutical Industries Limited Extended release liquid compositions of guanfacine
US10285908B2 (en) 2014-07-30 2019-05-14 Sun Pharmaceutical Industries Ltd Dual-chamber pack
US10369078B2 (en) 2016-05-02 2019-08-06 Sun Pharmaceutical Industries Limited Dual-chamber pack for pharmaceutical compositions
US10669063B2 (en) * 2012-08-17 2020-06-02 Archon Pharmaceutical Consulting Llc System for compounding and packaging ready to reconstitute drug powders of solutions to a solution or to a suspension or to an injectable
US10981713B2 (en) 2009-01-12 2021-04-20 Aktivax, Inc. Packaged products, inserts and compartments for aseptic mixing of substances, along with methods for use therewith
US11504345B2 (en) 2014-05-01 2022-11-22 Sun Pharmaceutical Industries Limited Extended release liquid compositions of metformin

Families Citing this family (11)

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DE2433716C2 (de) * 1974-07-13 1985-08-01 Henkel KGaA, 4000 Düsseldorf 2-Komponentenverpackung
DE2533036A1 (de) * 1975-07-24 1977-02-10 Merck Patent Gmbh Zweikammerspritze
EP0345230B1 (fr) * 1988-06-02 1994-09-14 Piero Marrucchi Procédé et dispositif pour manipuler et transférer des produits entre des volumes isolés
FR2655022B1 (fr) * 1989-11-30 1992-02-28 Oreal Dispositif applicateur d'un produit liquide ou pateux sur une surface.
US5199808A (en) * 1989-11-30 1993-04-06 L'oreal Device for application of a liquid or pasty product to a surface
FR2745492B1 (fr) * 1996-03-04 1998-06-12 Manni Charles Ensemble de conditionnement pour preparations lyophilisees
FR2758743B1 (fr) * 1997-01-24 1999-04-02 Stago Diagnostica Flacon en verre pour reactif utilisable par un automate d'analyse
WO2000002795A1 (fr) * 1998-07-10 2000-01-20 Pentapharm Ag Systeme de raccord double pour flacons
WO2003076296A1 (fr) 2002-03-13 2003-09-18 Henkel Kommanditgesellschaft Auf Aktien Emballage blister
DE10211303A1 (de) * 2002-03-13 2003-10-09 Henkel Kgaa Verpackungseinheit für ein Mehrkomponenten-Endprodukt
DE102004028921A1 (de) * 2004-06-15 2006-01-05 Sempre Hair-Color-Mix Gmbh Flaschensatz

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US2798488A (en) * 1954-09-15 1957-07-09 Merck & Co Inc Syringe unit
US2957609A (en) * 1958-11-06 1960-10-25 Burroughs Wellcome Co Device for dispensing muscle relaxant drugs
US2984570A (en) * 1959-04-23 1961-05-16 Sarah A Prell Dispenser container and method of altering the flavor and color of a substance packaged therein
US3206073A (en) * 1963-02-13 1965-09-14 Abbott Lab Dispensing assembly for a container and a sheath therefor
US3337039A (en) * 1963-05-27 1967-08-22 Union Carbide Corp Fluid storage mixing and dispensing containers
US3651990A (en) * 1969-10-23 1972-03-28 Edward J Cernei Container for keeping liquids in separate condition and commingling and dispensing the same
US3720523A (en) * 1970-10-16 1973-03-13 S Nakagami Dressing container assembly

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BE791634A (fr) * 1971-11-20 1973-05-21 Hoechst Ag Seringue a deux chambres
FR2552404B1 (fr) * 1983-09-26 1987-12-24 Merck Sharp & Dohme Ensemble de preparation et de delivrance d'une solution, bouchon obturateur pour cet ensemble et procede de fabrication de ce bouchon

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US2642870A (en) * 1950-08-26 1953-06-23 Arthur E Smith Receptacle closure
US2798488A (en) * 1954-09-15 1957-07-09 Merck & Co Inc Syringe unit
US2957609A (en) * 1958-11-06 1960-10-25 Burroughs Wellcome Co Device for dispensing muscle relaxant drugs
US2984570A (en) * 1959-04-23 1961-05-16 Sarah A Prell Dispenser container and method of altering the flavor and color of a substance packaged therein
US3206073A (en) * 1963-02-13 1965-09-14 Abbott Lab Dispensing assembly for a container and a sheath therefor
US3337039A (en) * 1963-05-27 1967-08-22 Union Carbide Corp Fluid storage mixing and dispensing containers
US3651990A (en) * 1969-10-23 1972-03-28 Edward J Cernei Container for keeping liquids in separate condition and commingling and dispensing the same
US3720523A (en) * 1970-10-16 1973-03-13 S Nakagami Dressing container assembly

Cited By (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559983A (en) * 1982-12-29 1985-12-24 Laboratoires Merck Sharp & Dohme Chibret Device for preparing and dispensing a solution
US4573506A (en) * 1983-09-26 1986-03-04 Laboratories Merck Sharp & Dohme - Chibret Two-bottle assembly for preparing and dispensing a solution
US4591049A (en) * 1984-01-16 1986-05-27 Kidde, Inc. Hermetically sealed two-component mixing system
US4858759A (en) * 1985-12-21 1989-08-22 Hilti Aktiengesellschaft Container arrangement for cartridge dispensing two-component mass
EP0246835A2 (fr) * 1986-05-21 1987-11-25 Johnsen & Jorgensen Jaypak Limited Systèmes et appareils pour mélanger des produits
EP0246835A3 (fr) * 1986-05-21 1988-01-07 Johnsen & Jorgensen Jaypak Limited Systèmes et appareils pour mélanger des produits
US4986322A (en) * 1987-03-24 1991-01-22 Societe Semco System of packaging for ready to use preparations
US4936446A (en) * 1988-03-02 1990-06-26 Laboratoires Merck, Sharp & Dohme-Chibret Packaging and dispensing system for packaging two ingredients separately and mixing them extemporaneously at the time of first use, and method of assembling same
US5207320A (en) * 1989-05-24 1993-05-04 Allen Nicholas J Compartmented mixing device with bead
US5257650A (en) * 1989-06-02 1993-11-02 Abbott Laboratories Two-piece reagent container assembly
US5454409A (en) * 1991-02-15 1995-10-03 Waverly Pharmaceutical, Ltd. Transfer adaptors
EP0503867A2 (fr) * 1991-03-08 1992-09-16 Material Engineering Technology Laboratory, Inc. Obturateur pour récipient, et dispositif de stockage et de mélange
EP0503867A3 (en) * 1991-03-08 1993-11-18 Shinsozai Sogo Kenkyusho Kk Stopper device for container, and storing and mixing apparatus
US5423793A (en) * 1991-03-08 1995-06-13 Material Engineering Technology Lab., Inc. Stopper device for container and mixing apparatus using the same
US5342347A (en) * 1991-08-29 1994-08-30 Nissho Corporation Drug container and dual container system for fluid therapy employing the same
US5209565A (en) * 1991-12-20 1993-05-11 L'oreal Assembly adapted for the mixing of two different products stored separately
US5380315A (en) * 1992-02-04 1995-01-10 Material Engineering Technology Laboratory Incorporated Mixing apparatus
US5409141A (en) * 1992-03-13 1995-04-25 Nissho Corporation Two component mixing and delivery system
US5342346A (en) * 1992-04-10 1994-08-30 Nissho Corporation Fluid container
US5465768A (en) * 1994-03-01 1995-11-14 Deroos; Bradley G. Fluid transport container
US5893484A (en) * 1995-07-14 1999-04-13 Ing. Erich Pfeiffer Gmbh Discharge device for fluid media, particularly for single-stroke only discharge
US6164501A (en) * 1996-02-08 2000-12-26 Tebro Device for dispensing a fluid contained in a hermetically closed container
AU732164B2 (en) * 1997-01-24 2001-04-12 Diagnostica Stago Seal for reagent flask usable by a blood analyser
US6237649B1 (en) * 1997-08-27 2001-05-29 Pentapharm Ag Dual vial connecting system for lyophilized products
US6610040B1 (en) 1997-12-04 2003-08-26 Baxter International Inc. Sliding reconstitution device with seal
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Also Published As

Publication number Publication date
FR2612892B2 (fr) 1989-09-08
LU67780A1 (fr) 1974-07-10
FR2612892A2 (fr) 1988-09-30
IT989075B (it) 1975-05-20
BE800782A (fr) 1973-12-12
FR2188565A5 (fr) 1974-01-18
DE2329704A1 (de) 1973-12-20

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