[go: up one dir, main page]

US3912450A - Method for synergistic disinfection or sterilization - Google Patents

Method for synergistic disinfection or sterilization Download PDF

Info

Publication number
US3912450A
US3912450A US361148A US36114873A US3912450A US 3912450 A US3912450 A US 3912450A US 361148 A US361148 A US 361148A US 36114873 A US36114873 A US 36114873A US 3912450 A US3912450 A US 3912450A
Authority
US
United States
Prior art keywords
percent
glutaraldehyde
weight
nonionic
sporicidal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US361148A
Other languages
English (en)
Inventor
Raymond Marcel Gut Boucher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wave Energy Systems Inc
Original Assignee
Wave Energy Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR7233008A priority Critical patent/FR2199470B1/fr
Priority to CH1363072A priority patent/CH564947A5/xx
Application filed by Wave Energy Systems Inc filed Critical Wave Energy Systems Inc
Priority to US361148A priority patent/US3912450A/en
Priority claimed from US05/596,289 external-priority patent/US3968250A/en
Application granted granted Critical
Publication of US3912450A publication Critical patent/US3912450A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/025—Ultrasonics
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/72—Ethers of polyoxyalkylene glycols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2072—Aldehydes-ketones
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/40—Specific cleaning or washing processes
    • C11D2111/46—Specific cleaning or washing processes applying energy, e.g. irradiation

Definitions

  • ABSTRACT A method for disinfecting or sterilizing medical, surgical, dental instruments or other objects in liquid phase with improved sporicidal compositions.
  • the method is based upon the synergistic effects observed when combining nonionic and anionic surfactants with aqueous or alcoholic glutaraldehyde solutions.
  • the method can be used also with ultrasonic irradiation over a wide frequency range (10 to 850 kHz). Two types of particularly effective synergistic sporicidal compositions are also described.
  • This invention relates to a method for disinfecting or sterilizing objects in liquid phase with improved chemosterilizer compositions.
  • the method object of our invention is based upon the synergistic sporicidal effects observed when using relatively moderate temperatures combined or not combined with ultrasonic irradiation in specially formulated sporicidal compositions.
  • the latter are based upon active combinations of glutaraldehyde with nonionic surfactants such as ethoxylates'or isomeric linear alcohols (C to C or anionic alkyl aryl sulfonates.
  • the method object of the present invention enables reducing from hours to minutes the time requirements for surface disinfection or sterilization of heat sensitive materials.
  • Formaldehyde isone of the oldest chemosterilizers employed for the destruction of spores, and, although 1 percent to 2 percent solutions have been used, a relatively long period of time (up to hours) is required to destroy Bacillus subtilis var. niger spores. A somewhat shorter time is needed if one uses higher concentrations of formaldehyde (around 8 percent) in isopropyl alcohol.
  • This solution, called Formalin has several drawbacks. The irritating fumes of formaldehyde limit its usefulness, and its toxicity for tissue requires that disinfected materials be thoroughly rinsed with sterile water before use.
  • Alkalanized glutaraldehyde solutions known commercially under the trade name CIDEX are the only widely used for practical applications today. They consist of a 2 percent aqueous glutaraldehyde solution buffered by suitable alkalinating agents (generally 0.3 percent sodium bicarbonate) to pH of 7.5 to 8.5. In the acid state at room temperature the glutaraldehyde solution is stable for long periods of time when stored in a closed container. However, when rendered alkaline, the glutaraldehyde gradually undergoes polymerization and loses its activity. Above pH 9 the polymerization proceeds very rapidly. In the 7.5 to 8.5 pH range polymerization is slower, but it is acknowledged by the manufacturer himself that sporicidal activity disappears after 2 weeks.
  • suitable alkalinating agents generally 0.3 percent sodium bicarbonate
  • Bacterial spores are much more resistant to adverse effects of heat, radiation and chemicals than their corresponding vegetative cells. The resistance of spores differs within the microbial population and species variation is common.
  • Bacillus subtilis Bacillus stea'rothermopilus, Bacillus pumilus, Clostridium sporogenes and Clostridium tetani.
  • a bacterial spore is typically about one micro diameter and consists essentially of a small cell, often called the core or spore protoplast, surrounded by a number of specialized layers.
  • the principal layers are the thick cortex and the multilayered coats and, around spores of certain species, a further loose and thin layer called exosporium.
  • alkylating agents such as ethylene oxide, B propiolactone, formaldehyde, glutaraldehyde as well as other aldehydes attack the sulfhydryl (SH), hydroxyl (OH), amino (NH and carboxy groups present in spore cell proteins.
  • alkylating agents such as ethylene oxide, B propiolactone, formaldehyde, glutaraldehyde as well as other aldehydes attack the sulfhydryl (SH), hydroxyl (OH), amino (NH and carboxy groups present in spore cell proteins.
  • T. J. Munton and A. D. Russell J. Appl. Bact., 1970
  • the chemical sites for glutaraldehyde action could involve NH groups, including cross linking reactions between these groups (D. Hopwood, Histochemie, 1968). According to these authors, however, the suggested mechanism does not exclude sites of action with other chemical groups.
  • the nonionic linear alcohol ethoxylates decrease the surface tension and increase the wettability at the spore/liquid interface in such a manner that they promote a faster absorbtion rate of glutaraldehyde molecules.
  • anionic alkyl aryl sulfonates mixed with nonionic polyoxethylene alcohol ethers.
  • sporicidal compositions object of the present invention in combination with ultrasonic irradiation extremely high killing rates are observed.
  • murein or peptidoglycan
  • Murein is present, in lesser amounts, in the walls of all bacteria. It is a large, cross-linked, net-like molecule exhibiting several unusual features.
  • This polymer is acidic, and in spores may exist as a layer tightly contracted by some positively charged molecules.
  • contractile pressure exerted by this structure may squeeze the central core sufficiently to maintain it in a state so dry as to confer heat resistance.
  • Ultrasonic irradiation is one of the most efficient techniques (KY Sergeeva, Sov. Phys. Acoust., March 1966) to shake up polymer lattices and produce a fast depolymerization.
  • This technique is said to be quite efficient over a wide frequency range both at low (G. Schmid, et al., Kolloid L, 1951) and high frequency (M. A. K. Mostafa, J. Polym. Sci. 1958).
  • murein depolymerization or a partial destruction of the tight cross-linked lattice would enable the aldehyde groups to penetrate and combine faster with the active spore sites.
  • Nonionic and anionic surfactants will indeed accelerate the penetration through the loosened polymer lattice.
  • High intensity ultrasonic energy could also play an important role through other secondary but important mechanisms.
  • the proteinaceous outer coats of spores contain a disulphide-rich protein with some properties close to those of keratins. Since keratin-like proteins are typically strong, inert towards chemical reagents and resistant to enzymes they constitute an ideal protective barrier for spores. High intensity ultrasonics, however, could physically degrade keratin (J. H. Bradbury, Nature, 1960) and thus promote a faster penetration of active glutaraldehyde molecules.
  • spores Two more components characteristic of spores are high levels of calcium (often 2 percent of the spores dry weight) and dipicolinic acid (DPA) which may account for over 10 percent of a spores dry weight. Under acoustic turbulence ion exchange (Ca depletion) can take place while the heterocyclic DPA molecule could also be broken (I. E. Elpiner and A. V. Sokolskaya, Sov. Phys. Acoust. March 1963). In short, ultrasonic energy could either accelerate the physical diffusion of molecules or active radicals to reaction sites inside the spores, produce chemical bond breakages of critical spore components (including site modification) or both.
  • DPA dipicolinic acid
  • a novel aqueous bactericidal, virucidal and sporicidal composition of the present invention is prepared with 2 percent glutaraldehyde (Union Carbide grade) and 0.2 percent of a nonionic surface active agent which is a mixture of ethoxylates of isomeric linear alcohols.
  • the linear alkyl hydrophobic portion of the surfactant being a mixture of C to C linear chains.
  • the hydrophylic portion being a polyoxyethylene chain (9 to 13 oxyethylene groups) randomly attached to the linear aliphatic chain through an ether linkage as shown in the following formula:
  • the nonionic surfactant used in the formulation object of the present invention had the following characteristics: Molecular weight 728, Cloud point (1 percent aqueous solution) 90C, Pour point 17C, 100 percent solubility in water at 25C, Apparent specific gravity 20/20C; 1.023, density 8.49 lb/gal at 30C, viscosity 48 CKS at 40C, flashpoint 460F. (ASTM method D).
  • the anionic surfactant blend with nonionic polyoxethylene alcohol ethers used in the second formulation object of the present invention had the following characteristics: Specific gravity 1.02, density 8.5- lb/gal, clear liquid soluble in hot or cold water, pH comprised between 6' and 8, freezing point -10C.
  • the spores against which the solutions have been tested were vacuum dried strains of Clostridium Sporogenes (ATCC 7955), Bacillus globigii, Bacillus pumilus, Bacillus stearolhermophilus and Bacillus Subtilis.
  • Tests were conducted in specially designed ultrasonic stainless steel tanks (Wave Energy Systems series CTG 160) with a 2 gallon capacity.
  • One gallon of spore suspension was used in each test.
  • the acoustic output in liquid phase could vary from 10 to watts per liter of spore suspension.
  • the experimental irradiation frequency was either 10 kHz or 27 k'Hz ,(i '1 kHz);
  • At high frequency 850 kHz 20 watts/liter to 5 watts/cc
  • the spore solution was contained in a 2 gal glass beaker which was placed in a water filled container fitted at the bottom with a submersible transducer (glazed cobalt lead zirconate titanate).
  • the temperature was thermostatically controlled to i 1C of the recited temperature.
  • spores of Bacillus subtilis were used in all the reported experiments.
  • the preparation of clean spores was accomplished with the G. Sierra and A. Bowman technique (Journ. Appl. Microbiology, 17: 372-378, 1969).
  • the spores were pasteurized (C, 15 min) and stored at 4C as concentrated suspensions in deionized water and used within one week.
  • the standardization of the spore suspensions was carried out as described by G. Sierra (Can. Journ. Microbiology, 13: 489-501, 1967).
  • Glutaraldehyde and glutaraldehyde/surfactant solutions were freshly prepared in deionized water for each experiment. Concentrated stock solution of the buffers or sodium bicarbonate were added'separately to pasteurized spore suspensions. The pH values reported here are those of a complete system after all additions and were read with a Beckman Zeromatic ll pH meter, the calibration of which was checked before each assay was run-Stirring was continuous, and the pH was read after allowing the electrode potential to stabilize.
  • Nonionic surfactant concentration 0.2% Glutaraldehyde Minimum time in minutes T mp r re: 55C Concentration for 100% kill I 2 30 no ultrasound Dfluem PH fi g; F862 5 30 no ultrasound km 2 10 with ultrasound and nonionic surfactant (0.2%) Deionized water 6 l0 2 20 no ultrasound but with Deionized water 8 (with buffer) l0 nonionic surfactant (0,2 7) Deionized water 10 (with buffer) l2 Water and isopropyl alcohol (667:) 6.5 10
  • a method for disinfecting or sterilizing medical, Deionized water 25 H dental, surgical instruments or other ob ects in liquid Deionized water 5 10 phase at a temperature of at least 15 C comprising contacting said object with a sporicidal composition comprising from about 0.1 percent by weight to about percent by weight of glutaraldehyde and from about 0.01 percent by weight to about 1 percent by weight of a nonionic surface active agent which is a mixture of ethoxylates of isomeric linear alcohols having the following formula:
  • n 9 to 13 and x is 9 to 13.
  • a method of disinfecting or sterilizing a contaminated object in liquid phase at a temperature of at least 15C comprising contacting said object with an aqueous sporicidal solution comprising from about 0.1 percent by weight to about 5 percent by weight of glutaraldehyde and from about 0.01 percent by weight to about 1 percent by weight of a nonionic surface active agent which is a mixture of ethoxylates of isomeric linear alcohols having the following formula:
  • n 9 to 13 and x is 9 to 13, while simultaneously subjecting said solution to sonic or ultrasonic fields having a frequency of from about 10 kHz to about 850 kHz and an acoustic energy density of about 1 watt per liter to about 5 watts per cubic centimeter inside the irradiated liquid phase.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
US361148A 1971-06-21 1973-05-17 Method for synergistic disinfection or sterilization Expired - Lifetime US3912450A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR7233008A FR2199470B1 (pt) 1971-06-21 1972-09-18
CH1363072A CH564947A5 (pt) 1971-06-21 1972-09-18
US361148A US3912450A (en) 1971-06-21 1973-05-17 Method for synergistic disinfection or sterilization

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US15523371A 1971-06-21 1971-06-21
FR7233008A FR2199470B1 (pt) 1971-06-21 1972-09-18
CH1363072A CH564947A5 (pt) 1971-06-21 1972-09-18
US361148A US3912450A (en) 1971-06-21 1973-05-17 Method for synergistic disinfection or sterilization
US48621074A 1974-07-05 1974-07-05
US05/596,289 US3968250A (en) 1971-06-21 1975-07-16 Method and sporicidal compositions for synergistic disinfection or sterilization
US05/596,372 US3968248A (en) 1971-06-21 1975-07-16 Method and sporicidal compositions for synergistic disinfection or sterilization

Publications (1)

Publication Number Publication Date
US3912450A true US3912450A (en) 1975-10-14

Family

ID=27561148

Family Applications (1)

Application Number Title Priority Date Filing Date
US361148A Expired - Lifetime US3912450A (en) 1971-06-21 1973-05-17 Method for synergistic disinfection or sterilization

Country Status (3)

Country Link
US (1) US3912450A (pt)
CH (1) CH564947A5 (pt)
FR (1) FR2199470B1 (pt)

Cited By (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4048336A (en) * 1974-04-22 1977-09-13 West Chemical Products, Incorporated Means for killing bacterial spores with glutaraldehyde sporicidal compositions
US4084747A (en) * 1976-03-26 1978-04-18 Howard Alliger Germ killing composition and method
US4093744A (en) * 1971-06-28 1978-06-06 West Laboratories, Inc. Killing bacterial spores with glutaraldehyde sporicidal compositions
US4103001A (en) * 1976-08-30 1978-07-25 Schattner Robert I Buffered phenol-glutaraldehyde sterilizing compositions
US4208404A (en) * 1974-07-29 1980-06-17 Cowan Stanley M Glutaraldehyde sterilizing compositions
US4211744A (en) * 1978-05-24 1980-07-08 Biophysics Research & Consulting Corporation Process for ultrasonic pasteurization
US4294797A (en) * 1979-04-24 1981-10-13 Kaltenbach & Voight Gmbh & Co. Servicing composition for spraying on medical instruments
US4308229A (en) * 1980-09-04 1981-12-29 Voit J Kenneth Sterilization apparatus and method
US4381314A (en) * 1980-11-21 1983-04-26 Bausch & Lomb Incorporated Contact lens disinfecting and preserving solution
US4389490A (en) * 1981-05-29 1983-06-21 Coulter Electronics, Inc. Method of stabilizing platelets for determining multiple platelet parameters in reference control and calibrator compositions; and diluents thereof
US4424188A (en) 1981-12-31 1984-01-03 International Paper Company Sterilization of packaging material
US4436754A (en) 1980-08-14 1984-03-13 Surgikos, Inc. Disinfecting and sterilizing composition
US4444785A (en) * 1980-11-21 1984-04-24 Bausch & Lomb Incorporated Contact lens disinfecting and preserving solution
US4448750A (en) * 1981-06-05 1984-05-15 Fuesting Michael L Sterilization method
WO1984001894A1 (en) * 1982-11-12 1984-05-24 American Hospital Supply Corp Chemical sterilization of implantable biological tissue
USRE31779E (en) * 1976-03-26 1984-12-25 Alcide Corporation Germ-killing composition and method
US4592892A (en) * 1981-11-12 1986-06-03 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Aqueous sterilizing agent for foods or food processing machines and utensils
US4607652A (en) * 1984-08-29 1986-08-26 Yung Simon K C Contact lens cleaning apparatus
US4690772A (en) * 1985-06-03 1987-09-01 National Medical Care Sterilant compositions
US4697605A (en) * 1984-08-29 1987-10-06 Smc Metal Tech Co., Ltd. Contact lens cleaning apparatus
EP0255875A1 (en) * 1986-08-08 1988-02-17 Germo S.P.A. Glutaraldehyde-based sterilising composition of antibacterial and antimycotic activity in an aqueous vehicle
US4847304A (en) * 1987-05-21 1989-07-11 Surgikos, Inc. Disinfecting and sterilizing composition
US4851449A (en) * 1987-05-21 1989-07-25 Surgikos, Inc. Odorless aromatic dialdehyde disinfecting and sterilizing composition
EP0360118A1 (de) * 1988-09-19 1990-03-28 Henkel Kommanditgesellschaft auf Aktien Verfahren zur Desinfektion von medizinischen Abformmassen
US4971999A (en) * 1987-05-21 1990-11-20 Johnson & Johnson Medical, Inc. Odorless aromatic dialdehyde disinfecting and sterilizing composition and method of using the same
US4978530A (en) * 1986-05-02 1990-12-18 Health Care Products, Inc. Sanitized, disinfected and sporicidal articles, and processes for sanitizing, disinfecting and rendering objects sporicidal
US5008023A (en) * 1990-08-13 1991-04-16 Betz Laboratories, Inc. Biocidal compositions and use thereof containing a synergistic mixture of glutaraldehyde and 2-(decylthio) enthanamine
WO1991016083A1 (en) * 1990-04-16 1991-10-31 Wave Energy Systems, Inc. Stable antimicrobial glutaraldehyde system
WO1992010935A1 (en) * 1990-12-20 1992-07-09 Glaxo S.P.A. Sterilising composition
US5250573A (en) * 1986-08-08 1993-10-05 Germo S.P.A. Glutaraldehyde-based sterilising composition of antibacterial and antimycotic activity, in an aqueous vehicle
WO1994013138A1 (en) * 1992-12-15 1994-06-23 Williams Robert M Sterilization devices, sporidical compositions, sterilization methods, and devices for reducing surface tension
EP0609106A1 (en) * 1993-01-29 1994-08-03 Toni Martin Marketing And Distributors Cc A glutaraldehyde composition
US5401625A (en) * 1993-06-24 1995-03-28 E. K. Industries, Inc. Histological composition for light microscopy
US5422068A (en) * 1994-01-05 1995-06-06 Shalaby; Shalaby W. Radiochemical sterilization
US5674829A (en) * 1993-01-29 1997-10-07 Antoinetta P. Martin Stable aqueous glutaraldehyde solutions containing sodium acetate and a nonionic detergent
US5736100A (en) * 1994-09-20 1998-04-07 Hitachi, Ltd. Chemical analyzer non-invasive stirrer
US6379685B1 (en) * 1997-09-26 2002-04-30 Ecolab Inc. Acidic aqueous chlorite teat dip with improved emollient providing shelf life, sanitizing capacity and tissue protection
US6387858B1 (en) * 2000-03-31 2002-05-14 Steris Inc. Safe transport gel for treating medical instruments
WO2003011027A1 (en) * 2001-07-27 2003-02-13 Antonietta Pamela Martin A glutaraldehyde composition
US20030190258A1 (en) * 2000-11-04 2003-10-09 Smith Francis X. Ophthalmic and contact lens solutions using low molecular weight amines
US6632397B1 (en) 1998-10-01 2003-10-14 Minntech Corporation Multi-part anti-microbial concentrate system, activated solution, use-dilution solution, method of making same, and method of sterilizing with the use-dilution solution
US20040043332A1 (en) * 2002-08-28 2004-03-04 Fujitsu Limited Method of manufacturing semiconductor device, and method of forming resist pattern
US20040110099A1 (en) * 2002-12-09 2004-06-10 Fujitsu Limited Process for forming resist pattern, semiconductor device and fabrication thereof
US6749869B1 (en) 1997-09-26 2004-06-15 Ecolab Acidic aqueous chlorite teat dip providing shelf life, sanitizing capacity and tissue protection
DE19626872B4 (de) * 1996-07-04 2005-01-27 Miele & Cie. Kg Spülverfahren für medizinische oder chirurgische Instrumente in einem programmgesteuerten Spülautomaten und Reiniger für das Verfahren
US20050042198A1 (en) * 1999-11-04 2005-02-24 Smith Francis X. Ophthalmic and contact lens wetting solutions
US6891069B1 (en) 2004-01-30 2005-05-10 Ethicon, Inc. Synthesis of 4-substituted phthalaldehyde
US20050136118A1 (en) * 2003-12-19 2005-06-23 Wu Su-Syin S. Distribution and preparation of germicidal compositions
US20050136086A1 (en) * 2003-12-19 2005-06-23 Rafael Herruzo Efficacy enhancers for germicides
US20050171201A1 (en) * 2004-01-30 2005-08-04 Zhu Peter C. Alpha-hydroxy sulfonate aldehydes, germicidal compositions containing the alpha-hydroxy sulfonate aldehydes, or mixtures of alpha-hydroxy sulfonate aldehydes and phthalaldehydes, and methods of using the compounds or compositions for disinfection or sterilization
US20050171215A1 (en) * 2004-01-30 2005-08-04 Ethicon, Inc. Germicidal compositions containing halogenated phthalaldehyes, and methods of using such compositions for disinfection or sterilization
US20050171121A1 (en) * 2004-01-30 2005-08-04 Zhu Peter C. Germicidal compositions containing phenylmalonaldehyde-type compounds, or mixtures of phenylmalonaldehyde-type compounds and phthalaldehydes, and methods of using such compositions for disinfection or sterilization
US20050171216A1 (en) * 2004-01-30 2005-08-04 Zhu Peter C. Germicidal compositions containing phthalaldehyde mixtures and methods of using such compositions for disinfection or sterilization
US20050238732A1 (en) * 2003-12-19 2005-10-27 Kaitao Lu Carbonated germicide with pressure control
US20060078626A1 (en) * 2000-11-08 2006-04-13 Bioconcept Laboratories Opthalmic and contact lens solutions with a peroxide source and a cationic polymeric preservative
US20060142169A1 (en) * 2000-11-08 2006-06-29 Bioconcept Laboratories Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
US20060148665A1 (en) * 2000-11-08 2006-07-06 Bioconcept Laboratories Ophthalmic and contact lens solutions containing forms of vitamin b
US20070004808A1 (en) * 2005-06-29 2007-01-04 Zhu Peter C Forming germicidal aromatic dialdehydes with acetals
US20070098818A1 (en) * 2000-11-08 2007-05-03 Fxs Ventures, Llc Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
US20070098813A1 (en) * 2000-11-08 2007-05-03 Fxs Ventures, Llc Ophthalmic and contact lens solutions with a peroxide source and a preservative
US20070104744A1 (en) * 2000-11-08 2007-05-10 Fxs Ventures, Llc Ophthalmic and contact lens solutions containing forms of vitamin b
US20080167246A1 (en) * 2003-04-15 2008-07-10 Bioconcept Laboratories Ophthalmic and Contact Lens Solutions Containing Peptides as Preservative
US20090227684A1 (en) * 2001-07-27 2009-09-10 Antonietta Pamela Martin Glutaraldehyde composition
JP2015505677A (ja) * 2011-12-23 2015-02-26 シージェイ チェルジェダン コーポレイション ポリエチレングリコール系非イオン性界面活性剤を用いた菌体の死滅化方法
US9308264B2 (en) 2000-11-08 2016-04-12 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT360172B (de) * 1978-12-22 1980-12-29 Oesterr Studien Atomenergie Verfahren zur sterilisation von thermolumines- zenzdosimetern
DE3032795C2 (de) 1980-08-30 1986-10-09 Schülke & Mayr GmbH, 2000 Norderstedt Desinfektionsmittel auf der Basis in 2-Stellung substituierter Glutardialdehyde
DE3611422A1 (de) * 1986-04-05 1987-10-15 Henkel Kgaa Verfahren zur reinigung verschmutzter fester formteile
EP0251743B1 (en) * 1986-06-27 1994-09-07 Reginald Keith Whiteley Liquid sterilising composition
FR2622397A1 (en) * 1987-11-03 1989-05-05 Sogeval Disinfectant composition

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2801216A (en) * 1956-04-05 1957-07-30 Union Carbide & Carbon Corp Treatment of water with dialdehyde bactericides
US3016328A (en) * 1961-01-03 1962-01-09 Ethicon Inc Dialdehyde alcoholic sporicidal composition
US3057775A (en) * 1959-02-04 1962-10-09 Champion Co Embalming composition
US3282775A (en) * 1963-05-10 1966-11-01 Ethicon Inc Sporicidal compositions comprising a saturated dialdehyde and a cationic surfactant
US3481687A (en) * 1965-03-08 1969-12-02 Sherman S Fishman Method and apparatus for ultrasonic sterilization
US3497590A (en) * 1967-08-24 1970-02-24 Colgate Palmolive Co Oral compositions containing non-toxic,non-volatile aliphatic aldehyde
US3697222A (en) * 1970-08-03 1972-10-10 Ontario Research Foundation Sterilization with glutaraldehyde

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2801216A (en) * 1956-04-05 1957-07-30 Union Carbide & Carbon Corp Treatment of water with dialdehyde bactericides
US3057775A (en) * 1959-02-04 1962-10-09 Champion Co Embalming composition
US3016328A (en) * 1961-01-03 1962-01-09 Ethicon Inc Dialdehyde alcoholic sporicidal composition
US3282775A (en) * 1963-05-10 1966-11-01 Ethicon Inc Sporicidal compositions comprising a saturated dialdehyde and a cationic surfactant
US3481687A (en) * 1965-03-08 1969-12-02 Sherman S Fishman Method and apparatus for ultrasonic sterilization
US3497590A (en) * 1967-08-24 1970-02-24 Colgate Palmolive Co Oral compositions containing non-toxic,non-volatile aliphatic aldehyde
US3697222A (en) * 1970-08-03 1972-10-10 Ontario Research Foundation Sterilization with glutaraldehyde

Cited By (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093744A (en) * 1971-06-28 1978-06-06 West Laboratories, Inc. Killing bacterial spores with glutaraldehyde sporicidal compositions
US4048336A (en) * 1974-04-22 1977-09-13 West Chemical Products, Incorporated Means for killing bacterial spores with glutaraldehyde sporicidal compositions
US4208404A (en) * 1974-07-29 1980-06-17 Cowan Stanley M Glutaraldehyde sterilizing compositions
US4084747A (en) * 1976-03-26 1978-04-18 Howard Alliger Germ killing composition and method
USRE31779E (en) * 1976-03-26 1984-12-25 Alcide Corporation Germ-killing composition and method
US4103001A (en) * 1976-08-30 1978-07-25 Schattner Robert I Buffered phenol-glutaraldehyde sterilizing compositions
US4211744A (en) * 1978-05-24 1980-07-08 Biophysics Research & Consulting Corporation Process for ultrasonic pasteurization
US4294797A (en) * 1979-04-24 1981-10-13 Kaltenbach & Voight Gmbh & Co. Servicing composition for spraying on medical instruments
US4436754A (en) 1980-08-14 1984-03-13 Surgikos, Inc. Disinfecting and sterilizing composition
US4308229A (en) * 1980-09-04 1981-12-29 Voit J Kenneth Sterilization apparatus and method
US4444785A (en) * 1980-11-21 1984-04-24 Bausch & Lomb Incorporated Contact lens disinfecting and preserving solution
US4381314A (en) * 1980-11-21 1983-04-26 Bausch & Lomb Incorporated Contact lens disinfecting and preserving solution
US4389490A (en) * 1981-05-29 1983-06-21 Coulter Electronics, Inc. Method of stabilizing platelets for determining multiple platelet parameters in reference control and calibrator compositions; and diluents thereof
US4448750A (en) * 1981-06-05 1984-05-15 Fuesting Michael L Sterilization method
US4592892A (en) * 1981-11-12 1986-06-03 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Aqueous sterilizing agent for foods or food processing machines and utensils
US4424188A (en) 1981-12-31 1984-01-03 International Paper Company Sterilization of packaging material
WO1984001894A1 (en) * 1982-11-12 1984-05-24 American Hospital Supply Corp Chemical sterilization of implantable biological tissue
JPS60500014A (ja) * 1982-11-12 1985-01-10 バツクスター　トラベノル　ラボラトリーズ　インコーポレーテツド 移殖できる生物学的組織の化学滅菌
US4607652A (en) * 1984-08-29 1986-08-26 Yung Simon K C Contact lens cleaning apparatus
US4697605A (en) * 1984-08-29 1987-10-06 Smc Metal Tech Co., Ltd. Contact lens cleaning apparatus
US4690772A (en) * 1985-06-03 1987-09-01 National Medical Care Sterilant compositions
US4978530A (en) * 1986-05-02 1990-12-18 Health Care Products, Inc. Sanitized, disinfected and sporicidal articles, and processes for sanitizing, disinfecting and rendering objects sporicidal
EP0255875A1 (en) * 1986-08-08 1988-02-17 Germo S.P.A. Glutaraldehyde-based sterilising composition of antibacterial and antimycotic activity in an aqueous vehicle
US5250573A (en) * 1986-08-08 1993-10-05 Germo S.P.A. Glutaraldehyde-based sterilising composition of antibacterial and antimycotic activity, in an aqueous vehicle
US4971999A (en) * 1987-05-21 1990-11-20 Johnson & Johnson Medical, Inc. Odorless aromatic dialdehyde disinfecting and sterilizing composition and method of using the same
US4847304A (en) * 1987-05-21 1989-07-11 Surgikos, Inc. Disinfecting and sterilizing composition
US4851449A (en) * 1987-05-21 1989-07-25 Surgikos, Inc. Odorless aromatic dialdehyde disinfecting and sterilizing composition
US5190724A (en) * 1988-09-19 1993-03-02 Henkel Kommanditgesellschaft Auf Aktien Process for disinfecting medical molding materials
WO1990003191A1 (de) * 1988-09-19 1990-04-05 Henkel Kommanditgesellschaft Auf Aktien Verfahren zur desinfektion von medizinischen abformmassen
EP0360118A1 (de) * 1988-09-19 1990-03-28 Henkel Kommanditgesellschaft auf Aktien Verfahren zur Desinfektion von medizinischen Abformmassen
US5447684A (en) * 1988-10-03 1995-09-05 Williams; Robert M. Sterilization devices, sporicidal compositions, sterilization methods, and devices for reducing surface tension
WO1991016083A1 (en) * 1990-04-16 1991-10-31 Wave Energy Systems, Inc. Stable antimicrobial glutaraldehyde system
US5008023A (en) * 1990-08-13 1991-04-16 Betz Laboratories, Inc. Biocidal compositions and use thereof containing a synergistic mixture of glutaraldehyde and 2-(decylthio) enthanamine
WO1992010935A1 (en) * 1990-12-20 1992-07-09 Glaxo S.P.A. Sterilising composition
WO1994013138A1 (en) * 1992-12-15 1994-06-23 Williams Robert M Sterilization devices, sporidical compositions, sterilization methods, and devices for reducing surface tension
US5783146A (en) * 1992-12-15 1998-07-21 Williams, Jr.; Robert M. Sporicidal compositions, sterlization devices and methods for rapid cleaning, disinfection, and sterilization
US5674829A (en) * 1993-01-29 1997-10-07 Antoinetta P. Martin Stable aqueous glutaraldehyde solutions containing sodium acetate and a nonionic detergent
AU671878B2 (en) * 1993-01-29 1996-09-12 Toni Martin Marketing And Distributors Cc A glutaraldehyde composition
EP0609106A1 (en) * 1993-01-29 1994-08-03 Toni Martin Marketing And Distributors Cc A glutaraldehyde composition
US5401625A (en) * 1993-06-24 1995-03-28 E. K. Industries, Inc. Histological composition for light microscopy
US5422068A (en) * 1994-01-05 1995-06-06 Shalaby; Shalaby W. Radiochemical sterilization
US5736100A (en) * 1994-09-20 1998-04-07 Hitachi, Ltd. Chemical analyzer non-invasive stirrer
DE19626872B4 (de) * 1996-07-04 2005-01-27 Miele & Cie. Kg Spülverfahren für medizinische oder chirurgische Instrumente in einem programmgesteuerten Spülautomaten und Reiniger für das Verfahren
USRE41279E1 (en) 1997-09-26 2010-04-27 Ecolab Inc. Acidic aqueous chlorite teat dip with improved visual indicator stability, extended shelf life, sanitizing capacity and tissue protection
US6379685B1 (en) * 1997-09-26 2002-04-30 Ecolab Inc. Acidic aqueous chlorite teat dip with improved emollient providing shelf life, sanitizing capacity and tissue protection
US6749869B1 (en) 1997-09-26 2004-06-15 Ecolab Acidic aqueous chlorite teat dip providing shelf life, sanitizing capacity and tissue protection
US6436444B1 (en) 1997-09-26 2002-08-20 Ecolab Inc. Acidic aqueous chlorite teat dip providing shelf life sanitizing capacity and tissue protection
US6699510B2 (en) 1997-09-26 2004-03-02 Ecolab Inc. Acidic aqueous chlorite teat dip with improved visual indicator stability, extended shelf life, sanitizing capacity and tissue protection
US6632397B1 (en) 1998-10-01 2003-10-14 Minntech Corporation Multi-part anti-microbial concentrate system, activated solution, use-dilution solution, method of making same, and method of sterilizing with the use-dilution solution
US8247461B2 (en) 1999-11-04 2012-08-21 Smith Francis X Ophthalmic and contact lens solution
US20100122918A1 (en) * 1999-11-04 2010-05-20 Smith Francis X Ophthalmic and contact lens solution
US20050042198A1 (en) * 1999-11-04 2005-02-24 Smith Francis X. Ophthalmic and contact lens wetting solutions
US6387858B1 (en) * 2000-03-31 2002-05-14 Steris Inc. Safe transport gel for treating medical instruments
US20030190258A1 (en) * 2000-11-04 2003-10-09 Smith Francis X. Ophthalmic and contact lens solutions using low molecular weight amines
US8557868B2 (en) 2000-11-04 2013-10-15 Fxs Ventures, Llc Ophthalmic and contact lens solutions using low molecular weight amines
US9492582B2 (en) 2000-11-08 2016-11-15 Fxs Ventures, Llc Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
US20060148665A1 (en) * 2000-11-08 2006-07-06 Bioconcept Laboratories Ophthalmic and contact lens solutions containing forms of vitamin b
US9585394B2 (en) 2000-11-08 2017-03-07 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B
US20070104744A1 (en) * 2000-11-08 2007-05-10 Fxs Ventures, Llc Ophthalmic and contact lens solutions containing forms of vitamin b
US9492581B2 (en) 2000-11-08 2016-11-15 Fxs Ventures, Llc Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
US9308264B2 (en) 2000-11-08 2016-04-12 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B
US20070098813A1 (en) * 2000-11-08 2007-05-03 Fxs Ventures, Llc Ophthalmic and contact lens solutions with a peroxide source and a preservative
US10595532B2 (en) 2000-11-08 2020-03-24 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B
US10064410B2 (en) 2000-11-08 2018-09-04 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B
US20060078626A1 (en) * 2000-11-08 2006-04-13 Bioconcept Laboratories Opthalmic and contact lens solutions with a peroxide source and a cationic polymeric preservative
US20060142169A1 (en) * 2000-11-08 2006-06-29 Bioconcept Laboratories Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
US20070098818A1 (en) * 2000-11-08 2007-05-03 Fxs Ventures, Llc Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
US20040242702A1 (en) * 2001-07-27 2004-12-02 Martin Antonietta Pamela Glutaraldehyde composition
US8729135B2 (en) 2001-07-27 2014-05-20 Antonietta Pamela Martin Glutaraldehyde composition
US20090227684A1 (en) * 2001-07-27 2009-09-10 Antonietta Pamela Martin Glutaraldehyde composition
WO2003011027A1 (en) * 2001-07-27 2003-02-13 Antonietta Pamela Martin A glutaraldehyde composition
US8257909B2 (en) * 2002-08-28 2012-09-04 Fujitsu Semiconductor Limited Method of manufacturing semiconductor device, and method of forming resist pattern
US20040043332A1 (en) * 2002-08-28 2004-03-04 Fujitsu Limited Method of manufacturing semiconductor device, and method of forming resist pattern
US8338080B2 (en) * 2002-12-09 2012-12-25 Fujitsu Limited Process for forming resist pattern, semiconductor device and fabrication thereof
US20040110099A1 (en) * 2002-12-09 2004-06-10 Fujitsu Limited Process for forming resist pattern, semiconductor device and fabrication thereof
US20110212885A1 (en) * 2003-04-15 2011-09-01 Smith Francis X Ophthalmic and contact lens solutions containing peptides as preservative
US20080167246A1 (en) * 2003-04-15 2008-07-10 Bioconcept Laboratories Ophthalmic and Contact Lens Solutions Containing Peptides as Preservative
US7939501B2 (en) 2003-04-15 2011-05-10 Smith Francis X Ophthalmic and contact lens solutions containing peptides as preservative
US20050238732A1 (en) * 2003-12-19 2005-10-27 Kaitao Lu Carbonated germicide with pressure control
US20050136086A1 (en) * 2003-12-19 2005-06-23 Rafael Herruzo Efficacy enhancers for germicides
US20050136118A1 (en) * 2003-12-19 2005-06-23 Wu Su-Syin S. Distribution and preparation of germicidal compositions
US20050171201A1 (en) * 2004-01-30 2005-08-04 Zhu Peter C. Alpha-hydroxy sulfonate aldehydes, germicidal compositions containing the alpha-hydroxy sulfonate aldehydes, or mixtures of alpha-hydroxy sulfonate aldehydes and phthalaldehydes, and methods of using the compounds or compositions for disinfection or sterilization
US7476767B2 (en) 2004-01-30 2009-01-13 Ethicon, Inc. Alpha-hydroxy sulfonate aldehydes, germicidal compositions containing the alpha-hydroxy sulfonate aldehydes, or mixtures of alpha-hydroxy sulfonate aldehydes and phthalaldehydes, and methods of using the compounds or compositions for disinfection or sterilization
US20050171216A1 (en) * 2004-01-30 2005-08-04 Zhu Peter C. Germicidal compositions containing phthalaldehyde mixtures and methods of using such compositions for disinfection or sterilization
US20050171121A1 (en) * 2004-01-30 2005-08-04 Zhu Peter C. Germicidal compositions containing phenylmalonaldehyde-type compounds, or mixtures of phenylmalonaldehyde-type compounds and phthalaldehydes, and methods of using such compositions for disinfection or sterilization
US20050171215A1 (en) * 2004-01-30 2005-08-04 Ethicon, Inc. Germicidal compositions containing halogenated phthalaldehyes, and methods of using such compositions for disinfection or sterilization
US7390837B2 (en) 2004-01-30 2008-06-24 Ethicon, Inc. Germicidal compositions containing phenylmalonaldehyde-type compounds, or mixtures of phenylmalonaldehyde-type compounds and phthalaldehydes, and methods of using such compositions for disinfection or sterilization
US6891069B1 (en) 2004-01-30 2005-05-10 Ethicon, Inc. Synthesis of 4-substituted phthalaldehyde
US20070004808A1 (en) * 2005-06-29 2007-01-04 Zhu Peter C Forming germicidal aromatic dialdehydes with acetals
US7291649B2 (en) 2005-06-29 2007-11-06 Ethicon, Inc. Forming germicidal aromatic dialdehydes with acetals
JP2015505677A (ja) * 2011-12-23 2015-02-26 シージェイ チェルジェダン コーポレイション ポリエチレングリコール系非イオン性界面活性剤を用いた菌体の死滅化方法
EP2796543A4 (en) * 2011-12-23 2015-08-05 Cj Cheiljedang Corp METHOD FOR STERILIZING MICROBIAL CELLS USING A NON-TENANT TENSID ON POLYETHYLENE GLYCOL BASIS
US9504271B2 (en) 2011-12-23 2016-11-29 Cj Cheiljedang Corporation Method for sterilizing microbial cells using polyethylene glycol-based nonionic surfactant

Also Published As

Publication number Publication date
FR2199470A1 (pt) 1974-04-12
FR2199470B1 (pt) 1977-12-30
CH564947A5 (pt) 1975-08-15

Similar Documents

Publication Publication Date Title
US3912450A (en) Method for synergistic disinfection or sterilization
US3968248A (en) Method and sporicidal compositions for synergistic disinfection or sterilization
US3697222A (en) Sterilization with glutaraldehyde
EP1064845B1 (en) Virucidal and sporicidal composition
AU2003302067B2 (en) Hydrogen peroxide disinfectant containing an acid and/or an alcohol
US5911951A (en) Method of sterilization
US5405602A (en) Nonaqueous cold sterilant
US4971999A (en) Odorless aromatic dialdehyde disinfecting and sterilizing composition and method of using the same
JPS6054922B2 (ja) 緩衝フエノ−ルジアルデヒド滅菌剤
JP2019521121A (ja) 抗菌性組成物およびその使用方法
JPH08504623A (ja) 亜塩素酸ナトリウムおよびポリビニルピロリドンを含有するコンタクトレンズ消毒溶液
Boucher Potentiated acid 1, 5 pentanedial solution—a new chemical sterilizing and disinfecting agent
US5985929A (en) Cold chemical sterilant
JP7058490B2 (ja) ウイルス、細菌および真菌を抑える抗菌組成物
CA1039183A (en) Oxydiacetaldehyde compositions and processes
Coates et al. Sporicidal activity of mixtures of alcohol and hypochlorite.
US6331514B1 (en) Sterilizing and disinfecting compound
KR102270164B1 (ko) 세정제 조성물
WO2001034754A1 (en) Sterilizing and disinfecting compound
EP0515626B1 (en) Sterilising composition
JP4879387B2 (ja) 殺芽胞剤組成物
JP2009500449A (ja) 結核菌殺菌活性が増大し臭気が減少した、酢酸塩およびアルコールを用いたグルタルアルデヒド消毒薬
NO138471B (no) Steriliserings- og desinfeksjonsmiddel
Gasparini et al. The sporicidal effects of a biodegradable peroxidic disinfectant
DE2246609A1 (de) Verfahren und sporicide zusammensetzung zur synergistischen desinfektion oder sterilisation