[go: up one dir, main page]

US3872867A - Wet-dry additive assembly - Google Patents

Wet-dry additive assembly Download PDF

Info

Publication number
US3872867A
US3872867A US35869373A US3872867A US 3872867 A US3872867 A US 3872867A US 35869373 A US35869373 A US 35869373A US 3872867 A US3872867 A US 3872867A
Authority
US
United States
Prior art keywords
sleevelike
end portion
vial
disposed
sheath
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Fred M Killinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to US35869373 priority Critical patent/US3872867A/en
Application granted granted Critical
Publication of US3872867A publication Critical patent/US3872867A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means

Definitions

  • This invention relates in general to a device for storing and supplying additives or'medicaments and, more particularly, to a type thereof including one sealed vial holding a diluent, another sealed vial holding an additive or medicament and interconnecting means for holding the vials together and for effecting selective communication between said vials, whereby said diluent can be mixed with said additive and thereafter fed into a passageway, such as a tube connected to a patient by a cannula for intravenous feeding.
  • a passageway such as a tube connected to a patient by a cannula for intravenous feeding.
  • additives or medicaments have long been aware of the fact that certain, additives, for example, tend to loose their effectiveness rather soon after they are mixed with a diluent in preparation for administration. Thus, they must be stored in a dry or non-liquid condition and then mixed with a diluent, preferably just before the additive is supplied, for example, to an intravenous bottle.
  • a primary object of this invention is the provision of a double vial assembly with a connecting structure between the vials whereby the sterility of the diluent and the additive or medicament in the vials is maintained prior to and during the mixing of the diluent with the additive and, at the same time, the cannula for the administration of the solution is shielded from contamination during the mixing and up to the very moment of insertion into the intravenous system or bottle.
  • a further object of this invention is the provision of a double vial assembly, as aforesaid, in which injectable additives or medicaments can be safely stored for relatively long periods of time, as in drug stores, clinics and doctors offices, along with a suitable diluent in a single package capable of mixing the diluent, and additive without any likelihood of contaminating the needle, the diluent or the additive.
  • a further object of this invention is the provision of an assembly, as aforesaid, which is rugged so that it cannot be readily damaged during shipment or storage, which is constructed so that accidental mixing of the diluent and the additive is positively opposed and, yet, wherein intentional mixing of the additive and the diluent can be effected safely, easily and quickly in preparation for supplying of the solution. by any person capable of following simple instructions.
  • FIG. 5 is a fragment of FIG. 2 showinga modified structure
  • an assembly including one sealed vial containing a diluent, another sealed vial containing an. additive or medicament, which may be liquid or dry, and a connection structure that includes a sheath and a cannula which extend between and are supported upon the sealed ends of the two vials.
  • the connection structure is arranged so that the sharpened ends of the cannula can be held spaced from, or slightly embedded in, the seals over the open ends of the vials.
  • the additive vial is under vacuum or the diluent vial is pressurized to effect movement of the diluent from its vial through the cannula into the additive vial after which the additive is dissolved in the diluent by gently shaking the assembly.
  • the diluent vial and sheath are now removed from the assembly so that the cannula is exposed and cube injected into an intravenous system of bottle whichis also undervacuum.
  • the double vial assembly 10 (FIGS. 1 and 2) is comprised of a vial 11 connected to a similar or identical vial 12 by an intermediate structure 13.
  • the vial 11 has a chamber 16, and the lower open mouth portion 18 thereof is of reduced diameter and is covered by a seal 19 which may be a resilient, flanged stopper.
  • the seal is held in place by the integral enlarged portion 22 of the sleeve 23 which is preferably fabricated from metal.
  • the sleeve 23 has a shoulder 24 which forms part of the enlarged portion 22 and presses the flange 25 of the seal 19 firmly against the lower end of the vial 16.
  • the vial 12 has an open mouth 36 which is covered by a seal, such as the flanged stopper 37, which is in turn held in place by the enlarged lower portion 38 of the sleeve 39. That is, the sleeve 39 has an integral shoulder 42 which bears downwardly against the flange of the stopper 37 thereby holding it tightly against the upper end 36 of the vial 12.
  • a seal such as the flanged stopper 37
  • a cannula 26, which is sharpened on both ends, has a hub 27 rigidly secured thereto and spaced from both ends thereof.
  • a tubular cannula support 28 has one end thereof secured to the hub 27 which it concentrically encircles. The remainder of the tubular support 28 is spaced radially outwardly from the cannula and projects toward the lower end thereof.
  • the tubular support 28 has an integral flange 29 at its lower end.
  • the hub 27. may be made from metal or plastic and the tubular support 28 is preferably fabricated from plastic. In some circumstances, the hu b 27 may be integral with and part of the tubular support 28.
  • the upper end portion of the sleeve 39 (FIG. 4) and the lower portion of the tubular support 28 have interferring deformations, such as annular ridges 32 and 33, respectively, by which the spaced relationship between the lower. end of the cannula 26 and the seal 37 is determined.
  • This spaced position is shown in FIG. 2.
  • the ridge 33 on the tubular support 28 is moved downwardly from between the two uppermost ridges 32 on the sleeve 23 until said ridge 33 moves past the lowermost ridge 32A, during which the seal 37 is penetrated by the cannula 26.
  • the ridge 32A and the ridge 33 hold the cannula in the penetrating position.
  • a substantially cylindrical sheath 43 extends from the enlarged portion 22 of sleeve 23 to the enlarged portion 38 of sleeve 39.
  • Said sheath 43 has a central cylindrical opening 44 the lower portion of which is sleeved snugly but slidably upon the tubular support 28.
  • Said sheath has a lower enlarged opening 46 with an inside diameter approximately equal to the outside diameter of the enlarged portion 38 of sleeve 39.
  • Said lower opening 46 is also slightly larger than the flange 29. at the lower end of the tubular support 28.
  • the engagement between the flange 29 and the shoulder 47 at the upper end of the lower opening 46 act to move the tubular support 28, hence the cannula 26, downwardly with the sheath 43.
  • the enlarged portion 38 is slidably received upwardly into the opening 46 in snug engagement with the lower part of sheath 43 defining the peripheral wall of the opening 46.
  • a flanged sleeve 45 is snugly disposed in the upper end of the central opening 44 (FIG. 3).
  • Said sleeve has an annular ridge 48 which coacts with annular ridges 49 on the sleeve 23.
  • the ridge 48 is located between the ridges 49 when the upper end of the cannula 29 is spaced from, or at least is not penetrating through, the stopper 19.
  • the sheath 43 can be moved upwardly relative to the sleeve 23 into a position where the ridge 48 is above the uppermost ridge 49A, at which time the cannula 26 penetrates completely through the stopper 19. Also, during this movement, the enlarged portion 22 on the sleeve 23 is slidably but snugly moved downwardly into the enlarged opening 52 at the upper end of the sheath 43 and coaxial with the central opening 44.
  • the vial 12 will be filled with a medicament, which may be a liquid or a dry powdery material produced by evaporative procedures, and the pressure in the vial 12 will preferably be reduced (that is, less than atmospheric).
  • the stopper 37 which is held in place by the sleeve 39, will be unperforated, and the vial 11 may be pressurized.
  • the vial 11 will contain a liquid and the sleeve 23 (FIG. 2) will hold theseal 19, which is also unperforated.
  • the cannula support 28, which is secured tothe cannula 26 through the hub 27, will be mounted upon the upper end of the sleeve 39 so that the ridge 33 near the lower end of the interior wall of the tubular support 28 is located between the two ridges 32 near the upper end of the sleeve 39. In this position, the cannula will be spaced from the seal 37.
  • the sheath 43 is now sleeved downwardly over the cannula 26 at the tubular support 28 until the shoulder 47 engages the flange 29.
  • the lower end 46 of the sheath 43 will preferably slightly overlap the enlarged portion 38 of the sleeve 39, which portion 38 surround the vial mouth 36.
  • the sheath 43 and vial 12 can now be simultaneously manually engaged in one hand while the vial 12 is engaged in the other hand and the sleeve 23 on the vial 11 is slidably inserted first into the enlarged opening 52 at the upper end of the sheath and then into the sleeve 45 in the upper end of the centralopening 44.
  • the assembly 10 is now in condition for shipment and/or storage as long as desired. While the diluent has been disclosed in the upper vial 11 and the medicament in the lower vial 12, this situation can be reversed. Also, it will be seen that the flanged sleeve 45 can be an integral part of the sheath 43.
  • the two vials 11 and 12 are either simultaneously or sequentially urged toward the sheath so that the cannula perforates and extends completely through the seals 19 and 37, thereby communicating with and between the chambers within the two vials.
  • the diluent in vial 11 will now move downwardly due to the differential pressure through the cannula into the vial 12.
  • the powdered or liquid material within the lower vial 12 is mixed with the diluent from the upper vial 11. If the mixed diluent and additive must be administered at once, the sheath 43 and vial l1 are moved upwardly away from the vial 12 and the tubular cannula support 28 so that the upper end of the cannula 26 is exposed.
  • the cannula will remain in position with respect to the vial 12 due to the interengagement of the ridges on the sleeve 39 with the ridge on the tubular support 28. That is, ridge 33 will be under the ridge 32A and the upper ridges 32 may be somewhat embedded in the interior wall of the tubular support 28.
  • the cannula 26 is inserted downwardly into an intravenous bottle, for example, in which the pressure is reduced so that the liquified additive is withdrawn from the vial 12 through the cannula 26 and into the l.V. bottle.
  • the stopper 37 of FlG. 3 may be replaced by the stopper 56 (FIG. 5) having an upward extension 57 into which the lower end of cannula 26 is embedded to seal the end thereof.
  • a double vial assembly for storing a medicament comprising:
  • first vial means defining a chamber therein and having a first elongated sleevelike end portion of reduced diameter, said first sleevelike end portion having a first flow opening therethrough for providing the only communication with said chamber;
  • perforable seal means blocking said first opening, said seal means being spaced inwardly from the outer end of said first opening as defined adjacent the free end of said first sleevelike end portion;
  • second vial means defining a chamber therein and having a second elongated sleevelike end portion of reduced diameter, said second sleevelike end portion having a second flow opening therethrough for providing the only communication with said chamber in said second vial means;
  • perforable stopper means blocking said second flow opening, said perforable stopper means being spaced inwardly of said second sleevelike opening from the outer end thereof as defined adjacent the free end of said second end portion;
  • cannula means extending between said first and second vial means, said cannula means having one end portion thereof loosely but slidably disposed within said first sleevelike end portion, the other end portion of said cannula means being loosely but slidably disposed within said second sleevelike end portion;
  • support means disposed in surrounding relationship to said cannula means and fixedly secured thereto at a location disposed between the ends thereof, said support means including a portion disposed in snug, slidable, telescopic engagement with said second sleevelike end portion;
  • releasable detent means coacting between said portion of said support means and said second sleevelike end portion for resisting movement of said cannula means relative to said second vial means;
  • sheath means surrounding said cannula means and extending between said first and second vial means for connecting same together, said sheath means including a first annular end portion having first and second sleevelike parts of different diameters disposed in surrounding relationship to said first sleevelike end portion and said first vial means, respectively, and disposed in snug slidable engagement therewith; said sheath means including a second annular end portion having first and second sleevelike parts of different diameters disposed in surrounding relationship to said second sleevelike end portion and said second vial means, respectively, and disposed in snug slidable engagement therewith, whereby said sheath means can be slidably disconnected from both said first and second vial means;
  • releasable detent means coacting between said first sleevelike end portion and said sheath means for resisting relative movement of said sheath means toward said first vial means.
  • said means coacting between said first sleevelike end portion and said sheath means includes an intermediate sleeve member snugly and slidably disposed within the first sleevelike part of said sheath.
  • said intermediate sleeve member being slidably disposed on and surrounding said first sleevelike end portion, and said releasable detent means coacting between said first sleevelike end portion and said intermediate sleeve member.
  • first and second sleevelike end portions are of substantially the same diameter
  • said first sleevelike part associated with the first annular end portion and the first sleevelike part associated with the second annular end portion are of the same diameter and are connected to one another to form an intermediate tubular portion of uniform diameter
  • said support means including a sleevelike support member disposed within said intermediate tubular portion and positioned in surrounding relationship to said second sleevelike end portion
  • said means coacting between said first sleevelike end portion and said sheath means including an intermediate sleeve member snugly and slidably disposed within the intermediate tubular portion of said sheath means and disposed in surrounding relationship to said first sleevelike end portion.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

A pair of vials each having a perforable seal closing an opening in one end thereof and a hollow cylindrical portion of reduced diameter adjacent the seal. A double-ended cannula is slidably receivable into the reduced end portions of the vials for perforating the seals to communicate with and between the interiors of the vials. A support on the cannula is removably engageable with the reduced portion on one of the vials. An elongated tubular sheath extends between and is slidably supported upon the cannula support and upon both of the vials.

Description

llnited States Patent [1 1 ltillinger [111 3,872,867 Mar. 25, 1975 WET-DRY ADDITIVE ASSEMBLY Inventor: Fred M. Killinger, Portage, Mich.
The Upjohn Company, Kalamazoo, Mich.
Filed: May 9, 1973 Appl. No.: 358,693
Related U.S. Application Data Continuation-in-part of Ser. No. 149,321, June 2, 1971, Pat. No. 3,788,369, Continuation-impart of Ser. No. 212,592, Dec. 27, 1971, Pat. No. 3,826,260.
Assignee:
U.S. Cl 128/272, 206/219, 128/DIG. 28 Int. Cl. A6lj 1/00 Field of Search 128/D1G. 28, 272, 218 M, 128/218 NV, 218 R, 218 N, 215, 216, 221, 218 D, 218 DA References Cited UNITED STATES PATENTS 3/1961 Murrish 128/272 8/1967 Sarnoff et a1 128/218 M 2/1968 Hassing et al 128/221 3,375,825 2/1968 Keller 128/221 3,392,726 7/1968 Pochyla et al 128/218 M X 3,563,373 2/1971 Paulson 128/218 M X 3,659,602 5/1972 Cloyd 128/220 Primary Examiner-Richard A. Gaudet Assistant Examiner-J. C. McGowan Attorney, Agent, or Firm-Woodhams, Blanchard and Flynn [57] ABSTRACT 4 Claims, 5 Drawing Figures WET-DRY ADDITIVE ASSEMBLY This application is a Continuation-in-Part of patent applications Ser. No. 149,321, filed June-2, 1971, now U.S. Pat. No. 3,788,369 and entitled APPARATUS FOR TRANSFERRING LIQUID BETWEEN A CON- TAINER AND A FLEXIBLE BAG, and Ser. No. 212,592, filed Dec. 27, 1971, now US. Pat. No. 3,826,260 entitled VIAL AND SYRINGE COMBI- NATION.
BACKGROUND OF THE INVENTION This invention relates in general to a device for storing and supplying additives or'medicaments and, more particularly, to a type thereof including one sealed vial holding a diluent, another sealed vial holding an additive or medicament and interconnecting means for holding the vials together and for effecting selective communication between said vials, whereby said diluent can be mixed with said additive and thereafter fed into a passageway, such as a tube connected to a patient by a cannula for intravenous feeding.
Persons familiar with the preparation and use of pa renteral. additives or medicaments have long been aware of the fact that certain, additives, for example, tend to loose their effectiveness rather soon after they are mixed with a diluent in preparation for administration. Thus, they must be stored in a dry or non-liquid condition and then mixed with a diluent, preferably just before the additive is supplied, for example, to an intravenous bottle.
In the past, it has been common practice to furnish separate vials of dry additive and diluent and to use a conventional syringe for transferring the diluent from one vial to another for the purpose of mixing the two in order to administer the additive. This arrangement involves the risk of contamination, the risk of improper dose and even the risk of mixing the wrong ingredients where the administration .of additive must be handled by unskilled persons.
Numerous attempts have been made to solve the foregoing problems as by furnishing syringes and vials connected together so that the supply and administration means are part of a package which is more readily usable. However, the previous combinations or packages involving an additive and a diluent have not proven satisfactory, heretofore, for a variety of reasons. For example, they have not satisfactorily avoided contamination, they have been too delicate for conventional storing and handling procedures, they have been too susceptible to accidental actuation whereby the materials are mixed too soon, and in general they have been almost as complicated and delicate to operate as the devices which they were intended to replace.
Accordingly, a primary object of this invention is the provision of a double vial assembly with a connecting structure between the vials whereby the sterility of the diluent and the additive or medicament in the vials is maintained prior to and during the mixing of the diluent with the additive and, at the same time, the cannula for the administration of the solution is shielded from contamination during the mixing and up to the very moment of insertion into the intravenous system or bottle.
A further object of this invention is the provision of a double vial assembly, as aforesaid, in which injectable additives or medicaments can be safely stored for relatively long periods of time, as in drug stores, clinics and doctors offices, along with a suitable diluent in a single package capable of mixing the diluent, and additive without any likelihood of contaminating the needle, the diluent or the additive.
A further object of this invention is the provision of an assembly, as aforesaid, which is rugged so that it cannot be readily damaged during shipment or storage, which is constructed so that accidental mixing of the diluent and the additive is positively opposed and, yet, wherein intentional mixing of the additive and the diluent can be effected safely, easily and quickly in preparation for supplying of the solution. by any person capable of following simple instructions.
Other objects and purposes of this invention will bei FIG. 5 is a fragment of FIG. 2 showinga modified structure; a
For convenience in description, the terms upper, lower and words of similar import will have reference to the double vial assembly or parts thereof as appearing in FIGS. 1 and 2. The terms inner, outer and derivatives thereof will have reference to the geometric center of the assembly and major components thereof. I
SUMMARY OF THE INVENTION The objects and purposes of the invention, including those set forth above, have been met by providing an assembly including one sealed vial containing a diluent, another sealed vial containing an. additive or medicament, which may be liquid or dry, and a connection structure that includes a sheath and a cannula which extend between and are supported upon the sealed ends of the two vials. The connection structure is arranged so that the sharpened ends of the cannula can be held spaced from, or slightly embedded in, the seals over the open ends of the vials. By effecting relative movement of the vials toward each other, the cannula pierces the seals and thereby communicates with and between the interiors of the vials. The additive vial is under vacuum or the diluent vial is pressurized to effect movement of the diluent from its vial through the cannula into the additive vial after which the additive is dissolved in the diluent by gently shaking the assembly. The diluent vial and sheath are now removed from the assembly so that the cannula is exposed and cube injected into an intravenous system of bottle whichis also undervacuum.
DETAILED DESCRIPTION The double vial assembly 10 (FIGS. 1 and 2) is comprised of a vial 11 connected to a similar or identical vial 12 by an intermediate structure 13. The vial 11 has a chamber 16, and the lower open mouth portion 18 thereof is of reduced diameter and is covered by a seal 19 which may be a resilient, flanged stopper. The seal is held in place by the integral enlarged portion 22 of the sleeve 23 which is preferably fabricated from metal. The sleeve 23 has a shoulder 24 which forms part of the enlarged portion 22 and presses the flange 25 of the seal 19 firmly against the lower end of the vial 16.
The vial 12 has an open mouth 36 which is covered by a seal, such as the flanged stopper 37, which is in turn held in place by the enlarged lower portion 38 of the sleeve 39. That is, the sleeve 39 has an integral shoulder 42 which bears downwardly against the flange of the stopper 37 thereby holding it tightly against the upper end 36 of the vial 12.
A cannula 26, which is sharpened on both ends, has a hub 27 rigidly secured thereto and spaced from both ends thereof. A tubular cannula support 28 has one end thereof secured to the hub 27 which it concentrically encircles. The remainder of the tubular support 28 is spaced radially outwardly from the cannula and projects toward the lower end thereof. The tubular support 28 has an integral flange 29 at its lower end. The hub 27. may be made from metal or plastic and the tubular support 28 is preferably fabricated from plastic. In some circumstances, the hu b 27 may be integral with and part of the tubular support 28.
The upper end portion of the sleeve 39 (FIG. 4) and the lower portion of the tubular support 28 have interferring deformations, such as annular ridges 32 and 33, respectively, by which the spaced relationship between the lower. end of the cannula 26 and the seal 37 is determined. This spaced position is shown in FIG. 2. By moving the tubular support28, hence the cannula 26, downwardly, the ridge 33 on the tubular support 28 is moved downwardly from between the two uppermost ridges 32 on the sleeve 23 until said ridge 33 moves past the lowermost ridge 32A, during which the seal 37 is penetrated by the cannula 26. The ridge 32A and the ridge 33 hold the cannula in the penetrating position.
A substantially cylindrical sheath 43 (FIG. 4) extends from the enlarged portion 22 of sleeve 23 to the enlarged portion 38 of sleeve 39. Said sheath 43 has a central cylindrical opening 44 the lower portion of which is sleeved snugly but slidably upon the tubular support 28. Said sheath has a lower enlarged opening 46 with an inside diameter approximately equal to the outside diameter of the enlarged portion 38 of sleeve 39. Said lower opening 46 is also slightly larger than the flange 29. at the lower end of the tubular support 28. Thus, as the sheath 43 is moved downwardly relative to the vial 12, the engagement between the flange 29 and the shoulder 47 at the upper end of the lower opening 46 act to move the tubular support 28, hence the cannula 26, downwardly with the sheath 43. At the same time, the enlarged portion 38 is slidably received upwardly into the opening 46 in snug engagement with the lower part of sheath 43 defining the peripheral wall of the opening 46.
A flanged sleeve 45 is snugly disposed in the upper end of the central opening 44 (FIG. 3). Said sleeve has an annular ridge 48 which coacts with annular ridges 49 on the sleeve 23. In this case, there are three ridges 49, two near the lower end of the sleeve and one near the upper end. The ridge 48 is located between the ridges 49 when the upper end of the cannula 29 is spaced from, or at least is not penetrating through, the stopper 19. The sheath 43 can be moved upwardly relative to the sleeve 23 into a position where the ridge 48 is above the uppermost ridge 49A, at which time the cannula 26 penetrates completely through the stopper 19. Also, during this movement, the enlarged portion 22 on the sleeve 23 is slidably but snugly moved downwardly into the enlarged opening 52 at the upper end of the sheath 43 and coaxial with the central opening 44.
OPERATION The operation of the double vial assembly (FIG. 1), to which this application applies, will be apparent to skilled persons upon reading the foregoing description. However, for convenience, such operation will now be summarized briefly.
In preparation, the vial 12 will be filled with a medicament, which may be a liquid or a dry powdery material produced by evaporative procedures, and the pressure in the vial 12 will preferably be reduced (that is, less than atmospheric). The stopper 37, which is held in place by the sleeve 39, will be unperforated, and the vial 11 may be pressurized.
The vial 11 will contain a liquid and the sleeve 23 (FIG. 2) will hold theseal 19, which is also unperforated. The cannula support 28, which is secured tothe cannula 26 through the hub 27, will be mounted upon the upper end of the sleeve 39 so that the ridge 33 near the lower end of the interior wall of the tubular support 28 is located between the two ridges 32 near the upper end of the sleeve 39. In this position, the cannula will be spaced from the seal 37.
The sheath 43 is now sleeved downwardly over the cannula 26 at the tubular support 28 until the shoulder 47 engages the flange 29. At the same time, the lower end 46 of the sheath 43 will preferably slightly overlap the enlarged portion 38 of the sleeve 39, which portion 38 surround the vial mouth 36. The sheath 43 and vial 12 can now be simultaneously manually engaged in one hand while the vial 12 is engaged in the other hand and the sleeve 23 on the vial 11 is slidably inserted first into the enlarged opening 52 at the upper end of the sheath and then into the sleeve 45 in the upper end of the centralopening 44. This sliding connection will be terminated when-the ridge 48 on the wall-defining the opening through the sleeve 45 is located between the ridges 49 on the sleeve 23. At this time, theupper end of the sheath 43 will be preferably telescoped slightly over the vial mouth 18, as by engaging the enlarged portion 22 of the sleeve 23.
The assembly 10 is now in condition for shipment and/or storage as long as desired. While the diluent has been disclosed in the upper vial 11 and the medicament in the lower vial 12, this situation can be reversed. Also, it will be seen that the flanged sleeve 45 can be an integral part of the sheath 43.
When it becomes desirable to administer the medicament in the vial 12, the two vials 11 and 12 are either simultaneously or sequentially urged toward the sheath so that the cannula perforates and extends completely through the seals 19 and 37, thereby communicating with and between the chambers within the two vials. The diluent in vial 11 will now move downwardly due to the differential pressure through the cannula into the vial 12.
By a gentle shaking action, the powdered or liquid material within the lower vial 12 is mixed with the diluent from the upper vial 11. If the mixed diluent and additive must be administered at once, the sheath 43 and vial l1 are moved upwardly away from the vial 12 and the tubular cannula support 28 so that the upper end of the cannula 26 is exposed. The cannula will remain in position with respect to the vial 12 due to the interengagement of the ridges on the sleeve 39 with the ridge on the tubular support 28. That is, ridge 33 will be under the ridge 32A and the upper ridges 32 may be somewhat embedded in the interior wall of the tubular support 28. The cannula 26 is inserted downwardly into an intravenous bottle, for example, in which the pressure is reduced so that the liquified additive is withdrawn from the vial 12 through the cannula 26 and into the l.V. bottle.
In a modified construction, the stopper 37 of FlG. 3 may be replaced by the stopper 56 (FIG. 5) having an upward extension 57 into which the lower end of cannula 26 is embedded to seal the end thereof.
Although particular preferred embodiments of the invention have been disclosed in detail for illustrative purposes, it will be recognized that variations or modifications of the disclosed apparatus, including the rearrangement of parts, lie within the scope of the present invention.
The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:
l. A double vial assembly for storing a medicament, comprising:
first vial means defining a chamber therein and having a first elongated sleevelike end portion of reduced diameter, said first sleevelike end portion having a first flow opening therethrough for providing the only communication with said chamber;
perforable seal means blocking said first opening, said seal means being spaced inwardly from the outer end of said first opening as defined adjacent the free end of said first sleevelike end portion;
second vial means defining a chamber therein and having a second elongated sleevelike end portion of reduced diameter, said second sleevelike end portion having a second flow opening therethrough for providing the only communication with said chamber in said second vial means;
perforable stopper means blocking said second flow opening, said perforable stopper means being spaced inwardly of said second sleevelike opening from the outer end thereof as defined adjacent the free end of said second end portion;
elongated double ended cannula means extending between said first and second vial means, said cannula means having one end portion thereof loosely but slidably disposed within said first sleevelike end portion, the other end portion of said cannula means being loosely but slidably disposed within said second sleevelike end portion;
support means disposed in surrounding relationship to said cannula means and fixedly secured thereto at a location disposed between the ends thereof, said support means including a portion disposed in snug, slidable, telescopic engagement with said second sleevelike end portion;
releasable detent means coacting between said portion of said support means and said second sleevelike end portion for resisting movement of said cannula means relative to said second vial means;
removable tubular sheath means surrounding said cannula means and extending between said first and second vial means for connecting same together, said sheath means including a first annular end portion having first and second sleevelike parts of different diameters disposed in surrounding relationship to said first sleevelike end portion and said first vial means, respectively, and disposed in snug slidable engagement therewith; said sheath means including a second annular end portion having first and second sleevelike parts of different diameters disposed in surrounding relationship to said second sleevelike end portion and said second vial means, respectively, and disposed in snug slidable engagement therewith, whereby said sheath means can be slidably disconnected from both said first and second vial means;
and
means, including releasable detent means, coacting between said first sleevelike end portion and said sheath means for resisting relative movement of said sheath means toward said first vial means.
2. An assembly according to claim 1, wherein said second vial means has the chamber thereof maintained under a pressure which is substantially below atmospheric pressure.
3. An assembly according to claim 1, wherein said means coacting between said first sleevelike end portion and said sheath means includes an intermediate sleeve member snugly and slidably disposed within the first sleevelike part of said sheath. means, said intermediate sleeve member being slidably disposed on and surrounding said first sleevelike end portion, and said releasable detent means coacting between said first sleevelike end portion and said intermediate sleeve member.
4. An assembly according to claim ll, wherein said first and second sleevelike end portions are of substantially the same diameter, wherein the said first sleevelike part associated with the first annular end portion and the first sleevelike part associated with the second annular end portion are of the same diameter and are connected to one another to form an intermediate tubular portion of uniform diameter, said support means including a sleevelike support member disposed within said intermediate tubular portion and positioned in surrounding relationship to said second sleevelike end portion, and said means coacting between said first sleevelike end portion and said sheath means including an intermediate sleeve member snugly and slidably disposed within the intermediate tubular portion of said sheath means and disposed in surrounding relationship to said first sleevelike end portion. =l

Claims (4)

1. A double vial Assembly for storing a medicament, comprising: first vial means defining a chamber therein and having a first elongated sleevelike end portion of reduced diameter, said first sleevelike end portion having a first flow opening therethrough for providing the only communication with said chamber; perforable seal means blocking said first opening, said seal means being spaced inwardly from the outer end of said first opening as defined adjacent the free end of said first sleevelike end portion; second vial means defining a chamber therein and having a second elongated sleevelike end portion of reduced diameter, said second sleevelike end portion having a second flow opening therethrough for providing the only communication with said chamber in said second vial means; perforable stopper means blocking said second flow opening, said perforable stopper means being spaced inwardly of said second sleevelike opening from the outer end thereof as defined adjacent the free end of said second end portion; elongated double ended cannula means extending between said first and second vial means, said cannula means having one end portion thereof loosely but slidably disposed within said first sleevelike end portion, the other end portion of said cannula means being loosely but slidably disposed within said second sleevelike end portion; support means disposed in surrounding relationship to said cannula means and fixedly secured thereto at a location disposed between the ends thereof, said support means including a portion disposed in snug, slidable, telescopic engagement with said second sleevelike end portion; releasable detent means coacting between said portion of said support means and said second sleevelike end portion for resisting movement of said cannula means relative to said second vial means; removable tubular sheath means surrounding said cannula means and extending between said first and second vial means for connecting same together, said sheath means including a first annular end portion having first and second sleevelike parts of different diameters disposed in surrounding relationship to said first sleevelike end portion and said first vial means, respectively, and disposed in snug slidable engagement therewith; said sheath means including a second annular end portion having first and second sleevelike parts of different diameters disposed in surrounding relationship to said second sleevelike end portion and said second vial means, respectively, and disposed in snug slidable engagement therewith, whereby said sheath means can be slidably disconnected from both said first and second vial means; and means, including releasable detent means, coacting between said first sleevelike end portion and said sheath means for resisting relative movement of said sheath means toward said first vial means.
2. An assembly according to claim 1, wherein said second vial means has the chamber thereof maintained under a pressure which is substantially below atmospheric pressure.
3. An assembly according to claim 1, wherein said means coacting between said first sleevelike end portion and said sheath means includes an intermediate sleeve member snugly and slidably disposed within the first sleevelike part of said sheath means, said intermediate sleeve member being slidably disposed on and surrounding said first sleevelike end portion, and said releasable detent means coacting between said first sleevelike end portion and said intermediate sleeve member.
4. An assembly according to claim 1, wherein said first and second sleevelike end portions are of substantially the same diameter, wherein the said first sleevelike part associated with the first annular end portion and the first sleevelike part associated with the second annular end portion are of the same diameter and are connected to one another to form an intermediate tubular portion of uniform diameter, said support means including a sleevelike support member disposed within said interMediate tubular portion and positioned in surrounding relationship to said second sleevelike end portion, and said means coacting between said first sleevelike end portion and said sheath means including an intermediate sleeve member snugly and slidably disposed within the intermediate tubular portion of said sheath means and disposed in surrounding relationship to said first sleevelike end portion.
US35869373 1971-06-02 1973-05-09 Wet-dry additive assembly Expired - Lifetime US3872867A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US35869373 US3872867A (en) 1971-06-02 1973-05-09 Wet-dry additive assembly

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14932171A 1971-06-02 1971-06-02
US35869373 US3872867A (en) 1971-06-02 1973-05-09 Wet-dry additive assembly

Publications (1)

Publication Number Publication Date
US3872867A true US3872867A (en) 1975-03-25

Family

ID=26846635

Family Applications (1)

Application Number Title Priority Date Filing Date
US35869373 Expired - Lifetime US3872867A (en) 1971-06-02 1973-05-09 Wet-dry additive assembly

Country Status (1)

Country Link
US (1) US3872867A (en)

Cited By (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3938518A (en) * 1975-01-15 1976-02-17 Astra Pharmaceutical Products Inc. Syringe attachment device
US3993063A (en) * 1975-06-16 1976-11-23 Union Carbide Corporation Protective shielding assembly for use in loading a hypodermic syringe with radioactive material
US3995630A (en) * 1974-09-12 1976-12-07 U.S. Philips Corporation Injection syringe with telescopic assembly between cartridge and vial
US3999543A (en) * 1976-02-06 1976-12-28 Illinois Tool Works Inc. Medicament additive system
US4161178A (en) * 1977-12-08 1979-07-17 Abbott Laboratories Additive transfer device
US4346820A (en) * 1979-05-02 1982-08-31 Sigma-Tau Industrie Farmaceutiche Riunite Apparatus for mixing and dispersing two substances under sterile conditions
US4361253A (en) * 1980-08-04 1982-11-30 Instrumentation Laboratory Inc. Liquid transfer device
US4410321A (en) * 1982-04-06 1983-10-18 Baxter Travenol Laboratories, Inc. Closed drug delivery system
US4411662A (en) * 1982-04-06 1983-10-25 Baxter Travenol Laboratories, Inc. Sterile coupling
WO1983003539A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Container for mixing a liquid and a solid
WO1983003587A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Separated packaging and sterile processing for liquid-powder mixing
WO1985004801A1 (en) * 1984-04-16 1985-11-07 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US4573967A (en) * 1983-12-06 1986-03-04 Eli Lilly And Company Vacuum vial infusion system
US4591049A (en) * 1984-01-16 1986-05-27 Kidde, Inc. Hermetically sealed two-component mixing system
US4607671A (en) * 1984-08-21 1986-08-26 Baxter Travenol Laboratories, Inc. Reconstitution device
WO1986005683A1 (en) * 1985-04-03 1986-10-09 Mediplast Ab Transfer device
DE3510166A1 (en) * 1985-03-21 1987-01-22 Tecnotrans Ag REFILL CAP FOR CHEMICAL-PHARMACEUTICAL SUBSTANCES AND METHOD FOR THE PRODUCTION THEREOF
WO1987002239A1 (en) * 1985-10-09 1987-04-23 Kendall Mcgaw Laboratories, Inc. Connector
US4759756A (en) * 1984-09-14 1988-07-26 Baxter Travenol Laboratories, Inc. Reconstitution device
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
US4898209A (en) * 1988-09-27 1990-02-06 Baxter International Inc. Sliding reconstitution device with seal
US4936446A (en) * 1988-03-02 1990-06-26 Laboratoires Merck, Sharp & Dohme-Chibret Packaging and dispensing system for packaging two ingredients separately and mixing them extemporaneously at the time of first use, and method of assembling same
US5088996A (en) * 1984-04-16 1992-02-18 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US5117875A (en) * 1988-06-02 1992-06-02 Piero Marrucchi Method and device for manipulating and transferring products between confined volumes
US5176673A (en) * 1988-06-02 1993-01-05 Piero Marrucchi Method and device for manipulating and transferring products between confined volumes
US5364369A (en) * 1987-07-08 1994-11-15 Reynolds David L Syringe
US5370164A (en) * 1988-10-20 1994-12-06 Galloway Company Aseptic fluid transfer apparatus and methods
US5445631A (en) * 1993-02-05 1995-08-29 Suntory Limited Fluid delivery system
US5456678A (en) * 1993-03-29 1995-10-10 Nicoletti; Pio Safety device for taking samples and performing infusions
WO1996024323A1 (en) * 1995-02-10 1996-08-15 Pharmacia & Upjohn Ab Transfer device
US5743312A (en) * 1995-04-11 1998-04-28 Behringwerke Aktiengesellschaft Component mixing apparatus and system including a movable cannula
WO1998017397A1 (en) * 1996-10-21 1998-04-30 Winkelman James W Apparatus and method for separating blood samples
WO1999038606A1 (en) * 1998-01-30 1999-08-05 Fusion Medical Technologies, Inc. Fluid dispersion and delivery assembly and method
US5957166A (en) * 1997-06-16 1999-09-28 Fusion Medical Technologies, Inc. Method and apparatus for dispersing fluid into a material
US6021824A (en) * 1995-03-02 2000-02-08 Novo Nordisk A/S Kit for storage and mixing of agents of which at least one is liquid
US6149623A (en) * 1996-01-11 2000-11-21 Duoject Medical Systems Inc. Delivery system for pharmaceuticals packed in pharmaceutical vials
US6378714B1 (en) * 1998-04-20 2002-04-30 Becton Dickinson And Company Transferset for vials and other medical containers
US20030055376A1 (en) * 2001-09-17 2003-03-20 Sedat Device for the bidirectional transfer of a liquid between a vial and a carpule
US20030067837A1 (en) * 2001-10-09 2003-04-10 Seaton James P. Multi-component, product handling and delivering system
EP1447072A1 (en) * 2003-02-13 2004-08-18 Becton Dickinson and Company Method and device for transferring fluids between collection tube holders
US6957745B2 (en) * 1998-04-20 2005-10-25 Becton, Dickinson And Company Transfer set
WO2006011751A1 (en) * 2004-07-30 2006-02-02 Lg Life Sciences, Ltd. Pharmaceutical mixing assembly
EP1345566B1 (en) * 2000-12-06 2006-06-07 Technoflex Reconstitution device in particular for mixing substances in the medical field
US20080172001A1 (en) * 2006-10-16 2008-07-17 Reynolds David L Reconstitution system for mixing the contents of a vial containing a first substance with a second substance stored in a cartridge
US20080177226A1 (en) * 2005-02-09 2008-07-24 Kaken Pharmaceutical Co., Ltd. Syringe Device and Method of Preparing Medicine Using the Device
US20090326448A1 (en) * 2006-04-18 2009-12-31 Pingan Huo Sterile Drug-Mixing Syringe
WO2010052707A1 (en) * 2008-11-04 2010-05-14 Situ Gen Ltd. Dually activated connector
US20110106021A1 (en) * 2009-10-30 2011-05-05 Revance Therapeutics, Inc. Device and Method for Topical Application of Therapeutics or Cosmetic Compositions
CN102481228A (en) * 2009-09-08 2012-05-30 泰尔茂株式会社 Mixing apparatus and piercing method for a double-ended needle
CN102985048A (en) * 2010-01-26 2013-03-20 弗雷泽纽斯卡比德国有限公司 Connector for containers containing medical agents
US20130231630A1 (en) * 2003-10-30 2013-09-05 Teva Medical Ltd. Safety drug handling device
US20140014547A1 (en) * 2011-03-28 2014-01-16 Terumo Kabushiki Kaisha Drug storage container
US20140034185A1 (en) * 2011-04-12 2014-02-06 Roche Diagnostics International Ag Connector Device
US20140261861A1 (en) * 2013-03-15 2014-09-18 Becton Dickinson and Company Limited Seal System for Cannula
US20150183560A1 (en) * 2009-09-14 2015-07-02 Nestec S.A. Package with foil seals and penetrating means
US9186635B2 (en) 2009-03-17 2015-11-17 Stryker Ireland Limited Vacuum mixing device for bone cement and method for mixing bone cement in said device
US20160199583A1 (en) * 2011-10-14 2016-07-14 Amgen Inc. Method of assembling and filling a drug delivery device
CN106456917A (en) * 2014-07-04 2017-02-22 阿普塔尔法国简易股份公司 Device for dispensing a fluid product
US9642774B2 (en) 2011-09-07 2017-05-09 Stryker European Holdings I, Llc Liquid container with predetermined breaking point
US10022531B2 (en) 2016-01-21 2018-07-17 Teva Medical Ltd. Luer lock adaptor
US10166347B1 (en) 2014-07-18 2019-01-01 Patrick Vitello Closure assembly for a medical device
US10166343B1 (en) 2015-03-13 2019-01-01 Timothy Brandon Hunt Noise evident tamper cap
US10183129B1 (en) 2010-12-03 2019-01-22 Medical Device Engineering, Llc Tamper indicating closure assembly
US10207099B1 (en) 2014-02-21 2019-02-19 Patrick Vitello Closure assembly for medical fitting
US10300263B1 (en) 2015-02-27 2019-05-28 Timothy Brandon Hunt Closure assembly for a medical connector
US10307548B1 (en) 2016-12-14 2019-06-04 Timothy Brandon Hunt Tracking system and method for medical devices
US10315024B1 (en) 2015-03-19 2019-06-11 Patick Vitello Torque limiting closure assembly
US20200030188A1 (en) * 2017-03-06 2020-01-30 All India Institute Of Medical Sciences (Aiims) A device, method and kit for the reconstitution of a solid or semi solid pharmaceutical composition
US10675628B2 (en) * 2014-04-02 2020-06-09 Merck Patent Gmbh Fluid transfer device and process of aseptically transferring a fluid
US10758684B1 (en) 2017-03-03 2020-09-01 Jonathan J. Vitello Tamper evident assembly
US10850037B2 (en) 2013-03-22 2020-12-01 Amgen Inc. Injector and method of assembly
USD903865S1 (en) 2018-11-19 2020-12-01 International Medical Industries, Inc. Self-righting tip cap
US10888672B1 (en) 2017-04-06 2021-01-12 International Medical Industries, Inc. Tamper evident closure assembly for a medical device
US10898659B1 (en) 2017-05-19 2021-01-26 International Medical Industries Inc. System for handling and dispensing a plurality of products
US10912898B1 (en) 2014-02-03 2021-02-09 Medical Device Engineering Llc Tamper evident cap for medical fitting
US10933202B1 (en) 2017-05-19 2021-03-02 International Medical Industries Inc. Indicator member of low strength resistance for a tamper evident closure
US10953162B1 (en) 2016-12-28 2021-03-23 Timothy Brandon Hunt Tamper evident closure assembly
US11040149B1 (en) 2017-03-30 2021-06-22 International Medical Industries Tamper evident closure assembly for a medical device
US11097071B1 (en) 2016-12-14 2021-08-24 International Medical Industries Inc. Tamper evident assembly
US11097055B2 (en) 2013-10-24 2021-08-24 Amgen Inc. Injector and method of assembly
US11278681B1 (en) 2018-02-20 2022-03-22 Robert Banik Tamper evident adaptor closure
USD948713S1 (en) 2019-09-03 2022-04-12 International Medical Industries, Inc. Asymmetrical self righting tip cap
US11357588B1 (en) 2019-11-25 2022-06-14 Patrick Vitello Needle packaging and disposal assembly
US11413406B1 (en) 2018-03-05 2022-08-16 Jonathan J. Vitello Tamper evident assembly
US11426328B1 (en) 2018-08-31 2022-08-30 Alexander Ollmann Closure for a medical container
US11471610B1 (en) 2018-10-18 2022-10-18 Robert Banik Asymmetrical closure for a medical device
US11523970B1 (en) 2020-08-28 2022-12-13 Jonathan Vitello Tamper evident shield
US11541180B1 (en) 2017-12-21 2023-01-03 Patrick Vitello Closure assembly having a snap-fit construction
US11690994B1 (en) 2018-07-13 2023-07-04 Robert Banik Modular medical connector
US11697527B1 (en) 2019-09-11 2023-07-11 Logan Hendren Tamper evident closure assembly
US11779520B1 (en) 2018-07-02 2023-10-10 Patrick Vitello Closure for a medical dispenser including a one-piece tip cap
US11793987B1 (en) 2018-07-02 2023-10-24 Patrick Vitello Flex tec closure assembly for a medical dispenser
US11857751B1 (en) 2018-07-02 2024-01-02 International Medical Industries Inc. Assembly for a medical connector
US11872187B1 (en) 2020-12-28 2024-01-16 Jonathan Vitello Tamper evident seal for a vial cover
US11904149B1 (en) 2020-02-18 2024-02-20 Jonathan Vitello Oral tamper evident closure with retained indicator
US11911339B1 (en) 2019-08-15 2024-02-27 Peter Lehel Universal additive port cap
US12070591B1 (en) 2020-12-14 2024-08-27 Patrick Vitello Snap action tamper evident closure assembly
US12172803B1 (en) 2021-10-04 2024-12-24 Patrick Vitello Tamper evident integrated closure

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2973758A (en) * 1956-12-27 1961-03-07 Invenex Pharmaceuticals Apparatus for manufacturing parenteral solutions
US3336924A (en) * 1964-02-20 1967-08-22 Sarnoff Two compartment syringe package
US3368557A (en) * 1964-05-28 1968-02-13 Novo Terapeutisk Labor As Ampoule with actuatable cover automatically readying ampoule for injection
US3375825A (en) * 1965-09-02 1968-04-02 Becton Dickinson Co Prefilled syringe
US3392726A (en) * 1965-08-09 1968-07-16 Upjohn Co Combination syringe and vial container
US3563373A (en) * 1967-10-06 1971-02-16 Paul E Paulson Hypodermic syringe assembly
US3659602A (en) * 1970-12-30 1972-05-02 Nosco Plastics Two component syringe

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2973758A (en) * 1956-12-27 1961-03-07 Invenex Pharmaceuticals Apparatus for manufacturing parenteral solutions
US3336924A (en) * 1964-02-20 1967-08-22 Sarnoff Two compartment syringe package
US3368557A (en) * 1964-05-28 1968-02-13 Novo Terapeutisk Labor As Ampoule with actuatable cover automatically readying ampoule for injection
US3392726A (en) * 1965-08-09 1968-07-16 Upjohn Co Combination syringe and vial container
US3375825A (en) * 1965-09-02 1968-04-02 Becton Dickinson Co Prefilled syringe
US3563373A (en) * 1967-10-06 1971-02-16 Paul E Paulson Hypodermic syringe assembly
US3659602A (en) * 1970-12-30 1972-05-02 Nosco Plastics Two component syringe

Cited By (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995630A (en) * 1974-09-12 1976-12-07 U.S. Philips Corporation Injection syringe with telescopic assembly between cartridge and vial
US3938518A (en) * 1975-01-15 1976-02-17 Astra Pharmaceutical Products Inc. Syringe attachment device
US3993063A (en) * 1975-06-16 1976-11-23 Union Carbide Corporation Protective shielding assembly for use in loading a hypodermic syringe with radioactive material
US3999543A (en) * 1976-02-06 1976-12-28 Illinois Tool Works Inc. Medicament additive system
US4161178A (en) * 1977-12-08 1979-07-17 Abbott Laboratories Additive transfer device
US4346820A (en) * 1979-05-02 1982-08-31 Sigma-Tau Industrie Farmaceutiche Riunite Apparatus for mixing and dispersing two substances under sterile conditions
US4361253A (en) * 1980-08-04 1982-11-30 Instrumentation Laboratory Inc. Liquid transfer device
US4411662A (en) * 1982-04-06 1983-10-25 Baxter Travenol Laboratories, Inc. Sterile coupling
US4410321A (en) * 1982-04-06 1983-10-18 Baxter Travenol Laboratories, Inc. Closed drug delivery system
WO1983003539A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Container for mixing a liquid and a solid
WO1983003540A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Sterile coupling
WO1983003587A1 (en) * 1982-04-06 1983-10-27 Baxter Travenol Lab Separated packaging and sterile processing for liquid-powder mixing
US4432755A (en) * 1982-04-06 1984-02-21 Baxter Travenol Laboratories, Inc. Sterile coupling
US4458733A (en) * 1982-04-06 1984-07-10 Baxter Travenol Laboratories, Inc. Mixing apparatus
US4467588A (en) * 1982-04-06 1984-08-28 Baxter Travenol Laboratories, Inc. Separated packaging and sterile processing for liquid-powder mixing
US4484920A (en) * 1982-04-06 1984-11-27 Baxter Travenol Laboratories, Inc. Container for mixing a liquid and a solid
US4573967A (en) * 1983-12-06 1986-03-04 Eli Lilly And Company Vacuum vial infusion system
US4591049A (en) * 1984-01-16 1986-05-27 Kidde, Inc. Hermetically sealed two-component mixing system
EP0161797A2 (en) * 1984-04-16 1985-11-21 Rudolph J. Kopfer Anti-aerosoling drug reconstitution device
WO1985004801A1 (en) * 1984-04-16 1985-11-07 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
EP0161797A3 (en) * 1984-04-16 1986-07-09 Rudolph J. Kopfer Anti-aerosoling drug reconstitution device
US5088996A (en) * 1984-04-16 1992-02-18 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US4619651A (en) * 1984-04-16 1986-10-28 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US4607671A (en) * 1984-08-21 1986-08-26 Baxter Travenol Laboratories, Inc. Reconstitution device
US4759756A (en) * 1984-09-14 1988-07-26 Baxter Travenol Laboratories, Inc. Reconstitution device
DE3510166A1 (en) * 1985-03-21 1987-01-22 Tecnotrans Ag REFILL CAP FOR CHEMICAL-PHARMACEUTICAL SUBSTANCES AND METHOD FOR THE PRODUCTION THEREOF
WO1986005683A1 (en) * 1985-04-03 1986-10-09 Mediplast Ab Transfer device
US4675020A (en) * 1985-10-09 1987-06-23 Kendall Mcgaw Laboratories, Inc. Connector
WO1987002239A1 (en) * 1985-10-09 1987-04-23 Kendall Mcgaw Laboratories, Inc. Connector
US5137511A (en) * 1987-07-08 1992-08-11 Duoject Medical Systems Inc. Syringe
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
US5364369A (en) * 1987-07-08 1994-11-15 Reynolds David L Syringe
US4936446A (en) * 1988-03-02 1990-06-26 Laboratoires Merck, Sharp & Dohme-Chibret Packaging and dispensing system for packaging two ingredients separately and mixing them extemporaneously at the time of first use, and method of assembling same
US5117875A (en) * 1988-06-02 1992-06-02 Piero Marrucchi Method and device for manipulating and transferring products between confined volumes
US5176673A (en) * 1988-06-02 1993-01-05 Piero Marrucchi Method and device for manipulating and transferring products between confined volumes
WO1990003536A1 (en) * 1988-09-27 1990-04-05 Baxter International Inc. Sliding reconstitution device with seal
US4898209A (en) * 1988-09-27 1990-02-06 Baxter International Inc. Sliding reconstitution device with seal
US5370164A (en) * 1988-10-20 1994-12-06 Galloway Company Aseptic fluid transfer apparatus and methods
US5445631A (en) * 1993-02-05 1995-08-29 Suntory Limited Fluid delivery system
US5456678A (en) * 1993-03-29 1995-10-10 Nicoletti; Pio Safety device for taking samples and performing infusions
WO1996024323A1 (en) * 1995-02-10 1996-08-15 Pharmacia & Upjohn Ab Transfer device
US6021824A (en) * 1995-03-02 2000-02-08 Novo Nordisk A/S Kit for storage and mixing of agents of which at least one is liquid
US5743312A (en) * 1995-04-11 1998-04-28 Behringwerke Aktiengesellschaft Component mixing apparatus and system including a movable cannula
AU697521B2 (en) * 1995-04-11 1998-10-08 Csl Behring Gmbh Apparatus for combining a first liquid component and a second solid or liquid component by means of reduced pressure under sterile conditions
US20040024354A1 (en) * 1996-01-11 2004-02-05 Reynolds David L. Transfer device and method for transferring a pharmaceutical component between a vial and a syringe
US6638244B1 (en) * 1996-01-11 2003-10-28 Duoject Medical Systems Inc. Delivery system for multi-component pharmaceuticals
US6149623A (en) * 1996-01-11 2000-11-21 Duoject Medical Systems Inc. Delivery system for pharmaceuticals packed in pharmaceutical vials
US6132353A (en) * 1996-10-21 2000-10-17 Winkelman; James W. Apparatus and method for separating plasma or serum from the red cells of a blood sample
US6398705B1 (en) * 1996-10-21 2002-06-04 Manfred Grumberg Apparatus for separating plasma or serum from the red cells with a blood sample
WO1998017397A1 (en) * 1996-10-21 1998-04-30 Winkelman James W Apparatus and method for separating blood samples
US5957166A (en) * 1997-06-16 1999-09-28 Fusion Medical Technologies, Inc. Method and apparatus for dispersing fluid into a material
AU740645B2 (en) * 1998-01-30 2001-11-08 Fusion Medical Technologies, Inc. Fluid dispersion and delivery assembly and method
WO1999038606A1 (en) * 1998-01-30 1999-08-05 Fusion Medical Technologies, Inc. Fluid dispersion and delivery assembly and method
US6378714B1 (en) * 1998-04-20 2002-04-30 Becton Dickinson And Company Transferset for vials and other medical containers
US6957745B2 (en) * 1998-04-20 2005-10-25 Becton, Dickinson And Company Transfer set
EP1345566B1 (en) * 2000-12-06 2006-06-07 Technoflex Reconstitution device in particular for mixing substances in the medical field
US6752180B2 (en) * 2001-09-17 2004-06-22 Sedat Device for the bidirectional transfer of a liquid between a vial and a carpule
US20030055376A1 (en) * 2001-09-17 2003-03-20 Sedat Device for the bidirectional transfer of a liquid between a vial and a carpule
EP1441842A1 (en) * 2001-10-09 2004-08-04 Immedica Multi-component, product handling and delivering system
US20030067837A1 (en) * 2001-10-09 2003-04-10 Seaton James P. Multi-component, product handling and delivering system
EP1441842A4 (en) * 2001-10-09 2006-04-12 Immedica Multi-component, product handling and delivering system
US6572256B2 (en) * 2001-10-09 2003-06-03 Immedica Multi-component, product handling and delivering system
EP1447072A1 (en) * 2003-02-13 2004-08-18 Becton Dickinson and Company Method and device for transferring fluids between collection tube holders
US20040162540A1 (en) * 2003-02-13 2004-08-19 Becton, Dickinson And Company Transfer device
US9532927B2 (en) * 2003-10-30 2017-01-03 Teva Medical Ltd. Safety drug handling device
US20130231630A1 (en) * 2003-10-30 2013-09-05 Teva Medical Ltd. Safety drug handling device
US9345641B2 (en) * 2003-10-30 2016-05-24 Teva Medical Ltd. Safety drug handling device
US20140020792A1 (en) * 2003-10-30 2014-01-23 Teva Medical Ltd. Safety drug handling device
WO2006011751A1 (en) * 2004-07-30 2006-02-02 Lg Life Sciences, Ltd. Pharmaceutical mixing assembly
US7597680B2 (en) * 2005-02-09 2009-10-06 Kaken Pharmaceutical Co., Ltd. Syringe device and method of preparing medicine using the device
US20080177226A1 (en) * 2005-02-09 2008-07-24 Kaken Pharmaceutical Co., Ltd. Syringe Device and Method of Preparing Medicine Using the Device
US8007461B2 (en) * 2006-04-18 2011-08-30 Pingan Huo Sterile drug-mixing syringe
US20090326448A1 (en) * 2006-04-18 2009-12-31 Pingan Huo Sterile Drug-Mixing Syringe
US8100154B2 (en) * 2006-10-16 2012-01-24 Duoject Medical Systems Inc. Reconstitution system for mixing the contents of a vial containing a first substance with a second substance stored in a cartridge
US20080172001A1 (en) * 2006-10-16 2008-07-17 Reynolds David L Reconstitution system for mixing the contents of a vial containing a first substance with a second substance stored in a cartridge
WO2010052707A1 (en) * 2008-11-04 2010-05-14 Situ Gen Ltd. Dually activated connector
US9999459B2 (en) 2009-03-17 2018-06-19 Stryker European Holdings I, Llc Vacuum mixing device for bone cement and method for mixing bone cement in said device
US9186635B2 (en) 2009-03-17 2015-11-17 Stryker Ireland Limited Vacuum mixing device for bone cement and method for mixing bone cement in said device
US20120172830A1 (en) * 2009-09-08 2012-07-05 Terumo Kabushiki Kaisha Mixing apparatus and piercing method for a double-ended needle
CN102481228B (en) * 2009-09-08 2014-07-09 泰尔茂株式会社 Mixing apparatus and piercing method for a double-ended needle
CN102481228A (en) * 2009-09-08 2012-05-30 泰尔茂株式会社 Mixing apparatus and piercing method for a double-ended needle
US20150183560A1 (en) * 2009-09-14 2015-07-02 Nestec S.A. Package with foil seals and penetrating means
US20110106021A1 (en) * 2009-10-30 2011-05-05 Revance Therapeutics, Inc. Device and Method for Topical Application of Therapeutics or Cosmetic Compositions
CN102985048B (en) * 2010-01-26 2016-03-16 弗雷泽纽斯卡比德国有限公司 For comprising the adapter of the container of medicinal active ingredient
CN102985048A (en) * 2010-01-26 2013-03-20 弗雷泽纽斯卡比德国有限公司 Connector for containers containing medical agents
US10183129B1 (en) 2010-12-03 2019-01-22 Medical Device Engineering, Llc Tamper indicating closure assembly
US8863948B2 (en) * 2011-03-28 2014-10-21 Terumo Kabushiki Kaisha Drug storage container
US20140014547A1 (en) * 2011-03-28 2014-01-16 Terumo Kabushiki Kaisha Drug storage container
US9254242B2 (en) * 2011-04-12 2016-02-09 Roche Diabetes Care, Inc. Connector device
US20160151242A1 (en) * 2011-04-12 2016-06-02 Roche Diagnostics International Ag Connector Device
US10045910B2 (en) * 2011-04-12 2018-08-14 Roche Diabetes Care, Inc. Connector device
US20140034185A1 (en) * 2011-04-12 2014-02-06 Roche Diagnostics International Ag Connector Device
US9642774B2 (en) 2011-09-07 2017-05-09 Stryker European Holdings I, Llc Liquid container with predetermined breaking point
US11298463B2 (en) 2011-10-14 2022-04-12 Amgen Inc. Method of assembling and filling a drug delivery device
US11129941B2 (en) * 2011-10-14 2021-09-28 Amgen Inc. Method of assembling and filling a drug delivery device
US11160931B2 (en) 2011-10-14 2021-11-02 Amgen Inc. Method of assembling and filling a drug delivery device
US11058821B2 (en) 2011-10-14 2021-07-13 Amgen Inc. Injector and method of assembly
US11273260B2 (en) 2011-10-14 2022-03-15 Amgen Inc. Injector and method of assembly
US11110225B2 (en) 2011-10-14 2021-09-07 Amgen Inc. Injector and method of assembly
US10537682B2 (en) 2011-10-14 2020-01-21 Amgen Inc. Injector and method of assembly
US20160199583A1 (en) * 2011-10-14 2016-07-14 Amgen Inc. Method of assembling and filling a drug delivery device
US10537681B2 (en) 2011-10-14 2020-01-21 Amgen Inc. Injector and method of assembly
US10314976B2 (en) 2011-10-14 2019-06-11 Amgen Inc. Method of assembling and filling a drug delivery device
US20140261861A1 (en) * 2013-03-15 2014-09-18 Becton Dickinson and Company Limited Seal System for Cannula
US10052259B2 (en) 2013-03-15 2018-08-21 Becton Dickinson and Company Ltd. Seal system for cannula
US9414990B2 (en) * 2013-03-15 2016-08-16 Becton Dickinson and Company Ltd. Seal system for cannula
US10850037B2 (en) 2013-03-22 2020-12-01 Amgen Inc. Injector and method of assembly
US11759571B2 (en) 2013-03-22 2023-09-19 Amgen Inc. Injector and method of assembly
US11097055B2 (en) 2013-10-24 2021-08-24 Amgen Inc. Injector and method of assembly
US11040154B1 (en) 2014-02-03 2021-06-22 Medical Device Engineering Llc Tamper evident cap for medical fitting
US10912898B1 (en) 2014-02-03 2021-02-09 Medical Device Engineering Llc Tamper evident cap for medical fitting
US10207099B1 (en) 2014-02-21 2019-02-19 Patrick Vitello Closure assembly for medical fitting
US10675628B2 (en) * 2014-04-02 2020-06-09 Merck Patent Gmbh Fluid transfer device and process of aseptically transferring a fluid
CN106456917A (en) * 2014-07-04 2017-02-22 阿普塔尔法国简易股份公司 Device for dispensing a fluid product
US10166347B1 (en) 2014-07-18 2019-01-01 Patrick Vitello Closure assembly for a medical device
US10300263B1 (en) 2015-02-27 2019-05-28 Timothy Brandon Hunt Closure assembly for a medical connector
US10166343B1 (en) 2015-03-13 2019-01-01 Timothy Brandon Hunt Noise evident tamper cap
US10315024B1 (en) 2015-03-19 2019-06-11 Patick Vitello Torque limiting closure assembly
US10682505B2 (en) 2016-01-21 2020-06-16 Simplivia Healthcare Ltd. Luer lock adaptor
US11517731B2 (en) 2016-01-21 2022-12-06 Simplivia Healthcare Ltd. Luer lock adaptor
US10022531B2 (en) 2016-01-21 2018-07-17 Teva Medical Ltd. Luer lock adaptor
US10307548B1 (en) 2016-12-14 2019-06-04 Timothy Brandon Hunt Tracking system and method for medical devices
US11097071B1 (en) 2016-12-14 2021-08-24 International Medical Industries Inc. Tamper evident assembly
US10953162B1 (en) 2016-12-28 2021-03-23 Timothy Brandon Hunt Tamper evident closure assembly
US10758684B1 (en) 2017-03-03 2020-09-01 Jonathan J. Vitello Tamper evident assembly
US11701301B2 (en) * 2017-03-06 2023-07-18 All India Institute Of Medical Sciences (Aiims) Device, method and kit for the reconstitution of a solid or semi solid pharmaceutical composition
US20200030188A1 (en) * 2017-03-06 2020-01-30 All India Institute Of Medical Sciences (Aiims) A device, method and kit for the reconstitution of a solid or semi solid pharmaceutical composition
US11040149B1 (en) 2017-03-30 2021-06-22 International Medical Industries Tamper evident closure assembly for a medical device
US10888672B1 (en) 2017-04-06 2021-01-12 International Medical Industries, Inc. Tamper evident closure assembly for a medical device
US10898659B1 (en) 2017-05-19 2021-01-26 International Medical Industries Inc. System for handling and dispensing a plurality of products
US10933202B1 (en) 2017-05-19 2021-03-02 International Medical Industries Inc. Indicator member of low strength resistance for a tamper evident closure
US11541180B1 (en) 2017-12-21 2023-01-03 Patrick Vitello Closure assembly having a snap-fit construction
US11278681B1 (en) 2018-02-20 2022-03-22 Robert Banik Tamper evident adaptor closure
US11413406B1 (en) 2018-03-05 2022-08-16 Jonathan J. Vitello Tamper evident assembly
US11857751B1 (en) 2018-07-02 2024-01-02 International Medical Industries Inc. Assembly for a medical connector
US11793987B1 (en) 2018-07-02 2023-10-24 Patrick Vitello Flex tec closure assembly for a medical dispenser
US11779520B1 (en) 2018-07-02 2023-10-10 Patrick Vitello Closure for a medical dispenser including a one-piece tip cap
US11690994B1 (en) 2018-07-13 2023-07-04 Robert Banik Modular medical connector
US11426328B1 (en) 2018-08-31 2022-08-30 Alexander Ollmann Closure for a medical container
US11471610B1 (en) 2018-10-18 2022-10-18 Robert Banik Asymmetrical closure for a medical device
USD903865S1 (en) 2018-11-19 2020-12-01 International Medical Industries, Inc. Self-righting tip cap
US11911339B1 (en) 2019-08-15 2024-02-27 Peter Lehel Universal additive port cap
USD948713S1 (en) 2019-09-03 2022-04-12 International Medical Industries, Inc. Asymmetrical self righting tip cap
US11697527B1 (en) 2019-09-11 2023-07-11 Logan Hendren Tamper evident closure assembly
US11357588B1 (en) 2019-11-25 2022-06-14 Patrick Vitello Needle packaging and disposal assembly
US11904149B1 (en) 2020-02-18 2024-02-20 Jonathan Vitello Oral tamper evident closure with retained indicator
US11523970B1 (en) 2020-08-28 2022-12-13 Jonathan Vitello Tamper evident shield
US12070591B1 (en) 2020-12-14 2024-08-27 Patrick Vitello Snap action tamper evident closure assembly
US11872187B1 (en) 2020-12-28 2024-01-16 Jonathan Vitello Tamper evident seal for a vial cover
US12172803B1 (en) 2021-10-04 2024-12-24 Patrick Vitello Tamper evident integrated closure
US12195241B1 (en) 2021-10-04 2025-01-14 Patrick Vitello Tamper evident integrated closure

Similar Documents

Publication Publication Date Title
US3872867A (en) Wet-dry additive assembly
US3826260A (en) Vial and syringe combination
US6558365B2 (en) Fluid transfer device
CA1234369A (en) Closed drug delivery system
US3788369A (en) Apparatus for transferring liquid between a container and a flexible bag
KR0160306B1 (en) Suction transfer assembly
US3826261A (en) Vial and syringe assembly
EP0416454B1 (en) Method of and apparatus for administering medicament to a patient
EP0085663B1 (en) Apparatus for mixing one substance with another substance
JP2936273B2 (en) Sliding reconstruction device with seal
JP2801207B2 (en) Syringe and method of assembling syringe
US6695829B2 (en) Container closure system
AU726258B2 (en) Reconstituting device for injectable medication
US4792329A (en) Multi-compartment syringe
US5641010A (en) Mixing and dispensing apparatus
CA1296296C (en) Connector and disposable assembly utilizing said connector
US5017186A (en) Device and method for maintaining sterility of multi-dose medicament vials
US4863454A (en) Dual bag intravenous preparation system
US4146153A (en) Sterile dispensing device
US3527216A (en) Hypodermic syringe assembly
JPS62502386A (en) Transfer device
JPS6072561A (en) Two-drug component syringe having vein display capacity
JPH04329956A (en) Germ-free holding/mixing apparatus for medicine held in individual sealed container
US3332421A (en) Combination syringe and vial mixing container
US11701301B2 (en) Device, method and kit for the reconstitution of a solid or semi solid pharmaceutical composition