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US3854703A - Method of and apparatus for promoting a reaction between a liquid specimen and a liquid reagent - Google Patents

Method of and apparatus for promoting a reaction between a liquid specimen and a liquid reagent Download PDF

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Publication number
US3854703A
US3854703A US00289344A US28934472A US3854703A US 3854703 A US3854703 A US 3854703A US 00289344 A US00289344 A US 00289344A US 28934472 A US28934472 A US 28934472A US 3854703 A US3854703 A US 3854703A
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US
United States
Prior art keywords
liquid
outlets
outlet
specimen
path
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00289344A
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English (en)
Inventor
D Gibbs
E Bennet
W Hopkinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vickers Ltd
Original Assignee
Vickers Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB4357571A external-priority patent/GB1365545A/en
Application filed by Vickers Ltd filed Critical Vickers Ltd
Application granted granted Critical
Publication of US3854703A publication Critical patent/US3854703A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/407—Mixers using gas or liquid agitation, e.g. with air supply tubes by blowing gas on the material from above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C53/00—Shaping by bending, folding, twisting, straightening or flattening; Apparatus therefor
    • B29C53/16—Straightening or flattening
    • B29C53/20—Straightening or flattening of tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2023/00—Tubular articles
    • B29L2023/22—Tubes or pipes, i.e. rigid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/110833—Utilizing a moving indicator strip or tape
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Definitions

  • ABSTRACT A reaction between a liquid specimen and a liquid reagent is promoted by applying the liquids to a liquidimpermeable support surface to form a mixture thereon, and the liquid mixture is agitated by directing a jet of gaseous fluid from a supply duct outlet to impinge thereon, and bringing about relative movement between the outlet and the support surface.
  • FIG! METHOD OF AND APPARATUS FOR PROMOTING A REACTION BETWEEN A LIQUID SPECIMEN AND A LIQUID REAGENT
  • This invention relates to methods of and apparatus for promoting a reaction between a liquid specimen and a liquid reagent.
  • a method of agitating liquid specimen material distributed for examination over a specimen support surface wherein a jet of gaseous fluid emerging from a supply duct outlet is caused to be incident upon the liquid material and relative movement is brought about between the support surface and the said supply duct outlet.
  • a specimen support surface and a supply duct arranged for directing a jet of gaseous fluid from an outlet of the duct to be incident upon liquid specimen material that is distributed for examination over the support surface when it is in use, there being means for bringing about relative movement between the support surface and the said outlet so as to cause agitation of the liquid specimen material.
  • a device for agitating liquid specimen material distributed along an upper surface of an elongate specimen support comprising guide means for determining a path along which the support can be moved in a lengthwise direction thereof through the device, and pneumatic jet-forming means having at least one outlet arranged, adjacent to the said guide means, for directing a jet of gaseous fluid so as to be incident upon the specimen material on the support surface,-when the device is in use, thereby to bring about agitation of the specimen material as the specimen support is moved, along the said path, past the or each said outlet.
  • the gaseous fluid i.e., gas or vapour
  • the gaseous fluid is preferably air.
  • FIG. 1 shows diagrammatically an elevation of apparatus for use in testing specimen materials
  • FIG. 2 shows a perspective view, partly cut away, of a device forming part of the FIG. 1 apparatus
  • FIG. 3 shows a plan view of a portion 'of specimen support tape
  • FIG. 4 shows diagrammatically a longitudinal sectional view of a first modification of the FIG. 2 device
  • FIG. 5 shows a perspective view, cut away, of a second modification of the FIG. 1 device
  • FIG. 6 shows a plan view of a portion of specimen support tape.
  • the apparatus shown in FIG. 1 is used to perform tests upon specimen materials, for example blood serum, by mixing a sample of each specimen material with reagent and observing the result of the reaction, if any, between the specimen material and the. reagent.
  • the apparatus comprises applicator means 1 whereby a succession of drops of reagent (and possibly also diluent) are applied to the upper surface of a horizontal specimen support tape 2 which is drawn through the apparatus by virtue of its being gripped between two rollers 3 of which one is driven to rotate.
  • the applicator means 1 also dispense a drop of specimen material into each drop of reagent, to provide a succession of pools distributed along the tape and each containing specimen material and reagent.
  • a pneumatic stirring device 4 whereby each pool of specimen material and reagent is thoroughly agitated to provide an homogeneous mixture.
  • the pneumatic stirring device is shown in more detail in FIG. 2. During passage of the pools through the pneumatic stirring device the reaction, if any, between the specimen material and the reagent takes place, and the result of the reaction is observed by optical means 5.
  • the pneumatic stirring device illustrated in FIG. 2 comprises a tape guide 6 formed with a groove 7 which has a flat bottom and straight sides.
  • A-distribution block 8 is positioned above the guide 6 so that it extends completely over the top of the groove 7.
  • Above the distribution block 8 is a gasket 9 and above that is a manifold top plate 10.
  • the components 8, 9 and 10 are held together by screws 11 and the guide 6 and the assembly 8/9/10 are held together by a spring clamp 12.
  • the block 8, the gasket 9 and the top plate 10 to gether define a chamber 13 which extends above the groove 7.
  • the chamber 13 communicates with the volume bounded by the groove 7 through a plurality of outlets 14.
  • Air from a supply cylinder 20 (FIG. 1) can be supplied under pressure to the chamber 13 through an inlet stub 15 provided on the top plate 10, and it leaves the chamber by way of the outlets 14 forming respective jets directed towards the bottom of the groove.
  • the outlets 14 along the groove are arranged alternately as outletpairs and single outlets.
  • the device 2 is used to agitate pools 17, containing specimen material and reagent, distributed along the upper surface of the specimen support tape 2.
  • the clamp 12 is removed and the assembly 8/9/10 is lifted from the guide 6 so as to expose the groove 7.
  • a lead-in portion of the tape is laid in the groove and the assembly 8/9/10 is then clamped in position once more.
  • the leading end of the tape is passed between the rollers 3 for drawing the tape through the groove in the direction of the arrow, and the inlet stub is connected to a supply of compressed air (not shown).
  • the tape is then drawn through the device, along the path defined by the groove in the guide, as the air is supplied to the chamber and issues from it through the outlets 14 forming jets directed onto the upper specimen-bearing surface of the tape.
  • the agitation brought about by the FIG. 2 device is used to promote chemical reactions between the speci-.
  • the air is humidified by passing the air from the cylinder 20 through a bath 18 (FIG. 1) of water and mixing it with dry air from a second cylinder 21.
  • the temperature of the air is also controlled by heating the water of the bath 18 with a thermostatically controlled immersion heater 19. It may in some circumstances be desired to dry the reaction product, in which case the temperature and humidity of the air are adjusted accordingly.
  • the specimen material may contain insufficient liquid in which case diluents as well as reagents may be added to the specimen material before it reaches the device.
  • a device in accordance with FIG. 2 has been constructed using Perspex for the components 6, 8 and 10 and butyl rubber for the gasket 9. A satisfactory amount of agitation was achieved with the device using air supplied to the inlet stub at about 5 p.s.i.
  • two single outlets provided by jet needles 22 are spaced apart along the groove, without an interposing outlet-pair.
  • the needles 22 are of cylindrical cross-section, and their central axes are inclined to the vertical at 45 but lie in the same vertical plane.
  • the inclined needles are directed forwardly, that is in the direction of tape movement, and air jets provided by the needles induce a vortex motion in the liquid of the pools, thereby producing a thorough mixing of the reacting components.
  • the depth of the groove is such that the clearance between the needles and the free surface of a pool 0.2 mm deep is less than five times the internal diameter of the jet needles.
  • the two jets provided by the outlet-pair converge to form an air curtain above the tape which causes the liquid to be carried towards the back of the pool until it finally passes through the air curtain to flow forward again.
  • the outlet-pairs are spaced apart along the groove by slightly more than the length of the pools in order to allow this pattern of movement to become established. For example, in the case of pools l2 mm long the outlet-pairs are spaced apart along the groove by 15 mm.
  • the outlets are approximately 4 mm above the tape, and for l0 p.l pools an air flow through each outlet-pair of approximately 0.6 l/min. is required.
  • specimen material it is not essential for the specimen material to be in discrete pools, as shown, but it could instead be in the form of a continuous trace extending along the tape.
  • the device shown in FIG. 2, or as modified in accordance with FIGS. 4 or 5, may be used in combination with other devices to treat specimen material to prepare it for subsequent microscopic examination, for example in the Vickers Cytological Screening Apparatus.
  • a method as claimed in claim 1, comprising the further steps of controlling the temperature and controlling the humidity of said gaseous fluid.
  • Apparatus for promoting a reaction between a liquid specimen and a liquid reagent comprising a liquidimpermeable support surface, first means for applying the liquid specimen to the support surface, second means for applying the liquid reagent to the support surface to form thereon a liquid mixture with the liquid specimen, a source of gaseous fluid, a supply duct having an inlet connected to said source and an outlet arranged to direct a jet of gaseous fluid from said source to impinge upon said liquid mixture on the support surface, and drive means connected to bring about relative movement between the support surface and said outlet thereby to cause agitation of the liquid mixture.
  • Apparatus as claimed in claim 3 further comprising means for controlling the temperature of said gaseous fluid and means for controlling the humidity of said gaseous fluid.
  • outlet is one of a plurality of such outlets all connected by way of the supply duct to said inlet and spaced apart along the path without additional outlets therebetween, each outlet of the plurality defining the end of a cylindrical passageway having a central axis lying in vertical plane parallel to said path and extending from said outlet both downwardly, at 45 to the vertical, and in said longitudinal direction.
  • first and second means are arranged to co-operate to provide on said upper surface as said drive means operate a succession of pools of given depth, distributed along said upper surface and each containing a mixture of liquid specimen and liquid reagent, which are carried on the specimen support from said first and second means and subsequently along said path, and there being between each outlet of the plurality and the upper surface of said support a clearance that is less than the sum of said given depth and five times the internal diameter of said cylindrical passageways.
  • said outlet is one of a plurality of such outlets which are connected to said inlet and which are distributed along said path, the outlets being arranged alternately singly and in pairs, the two outlets of each pair being spaced apart transversely with respect to said path.
  • said first and second means are arranged to provide on said upper surface a succession of pools of given length dis tributed along said upper surface and each containing a liquid specimen and a liquid reagent, and said outlet is one of a plurality of such outlets, said outlets being arranged in pairs and the pairs of outlets being spaced apart along said path by a distance greater than said given length and there being no additional outlets between successive pairs of outlets along' the path, each outlet of each pair defining the end of a cylindrical passageway having a central axis which is inclined to the vertical and lies in a vertical plane perpendicular to said path and which crosses the central axis of the cylindrical passageway whose end is defined by the other outlet of the pair below the pair of outlets.

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  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
US00289344A 1971-09-17 1972-09-15 Method of and apparatus for promoting a reaction between a liquid specimen and a liquid reagent Expired - Lifetime US3854703A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4357571A GB1365545A (en) 1971-09-17 1971-09-17 Agitation of liquid specimen material
GB1521872 1972-03-30

Publications (1)

Publication Number Publication Date
US3854703A true US3854703A (en) 1974-12-17

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US00289344A Expired - Lifetime US3854703A (en) 1971-09-17 1972-09-15 Method of and apparatus for promoting a reaction between a liquid specimen and a liquid reagent

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US (1) US3854703A (xx)
AU (1) AU464171B2 (xx)
BE (1) BE788877A (xx)
CA (1) CA976954A (xx)
DE (1) DE2245711A1 (xx)
FR (1) FR2153083B1 (xx)
IT (1) IT975006B (xx)
LU (1) LU66096A1 (xx)
NL (1) NL7212537A (xx)
SE (1) SE392170B (xx)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4676656A (en) * 1985-01-25 1987-06-30 Syntex (U.S.A.) Inc. Fluid handling apparatus and method
US4855601A (en) * 1986-10-30 1989-08-08 Societe Civile De Brevets, J.L.S. Method and device for automatic spectrometric analysis of a liquid, particularly of milk
US5650327A (en) * 1990-03-02 1997-07-22 Ventana Medical Systems, Inc. Method for mixing reagent and sample mounted on a slide
US5948359A (en) * 1997-03-21 1999-09-07 Biogenex Laboratories Automated staining apparatus
WO1999049295A1 (en) * 1998-03-24 1999-09-30 Biogenex Laboratories Automated staining apparatus
US6093574A (en) * 1997-08-11 2000-07-25 Ventana Medical Systems Method and apparatus for rinsing a microscope slide
US6192945B1 (en) 1997-08-11 2001-02-27 Ventana Medical Systems, Inc. Fluid dispenser
US6284546B1 (en) 1994-06-16 2001-09-04 Dade Behring Marburg Gmbh Method and device for photodetection
US20020034456A1 (en) * 1997-08-11 2002-03-21 Anthony Ford Fluid dispenser
US20020110494A1 (en) * 2000-01-14 2002-08-15 Ventana Medical Systems, Inc. Method and apparatus for modifying pressure within a fluid dispenser
US20040121484A1 (en) * 2002-12-19 2004-06-24 Tomas Betancourt Method and apparatus for mixing blood samples for cell analysis
US20050135972A1 (en) * 1997-08-11 2005-06-23 Ventana Medical Systems, Inc. Method and apparatus for modifying pressure within a fluid dispenser
EP1604734A2 (de) * 2004-06-11 2005-12-14 F. Hoffmann-La Roche Ag Verfahren und Vorrichtung zum Nachweis von Analyten
US20060190185A1 (en) * 1997-08-11 2006-08-24 Ventana Medical Systems, Inc. Memory management method and apparatus for automated biological reaction system
US7270785B1 (en) 2001-11-02 2007-09-18 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having fixed slide platforms
US7303725B2 (en) 2002-04-15 2007-12-04 Ventana Medical Systems, Inc. Automated high volume slide staining system
US7378055B2 (en) 2002-04-26 2008-05-27 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having fixed slide platforms
US7400983B2 (en) 2002-12-20 2008-07-15 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US7468161B2 (en) 2002-04-15 2008-12-23 Ventana Medical Systems, Inc. Automated high volume slide processing system
US8790596B2 (en) 2011-06-01 2014-07-29 Ventana Medical Systems, Inc. Dispenser with filter device
US10184862B2 (en) 2008-11-12 2019-01-22 Ventana Medical Systems, Inc. Methods and apparatuses for heating slides carrying specimens
US10794805B2 (en) 2013-12-13 2020-10-06 Ventana Medical Systems, Inc. Automated histological processing of biological specimens and associated technology
US11249095B2 (en) 2002-04-15 2022-02-15 Ventana Medical Systems, Inc. Automated high volume slide processing system

Families Citing this family (3)

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US4597944A (en) * 1983-10-18 1986-07-01 Cottingham Hugh V Agglutination reagent detection system
DE3434931A1 (de) * 1984-09-22 1986-03-27 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Verfahren und vorrichtung zum mischen einer zu analysierenden fluessigkeitsprobe
DE102007056938A1 (de) * 2007-11-24 2009-05-28 Katz, Elisabeth Vorrichtung zur Online-Analyse von Schlämmen und Suspensionen

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* Cited by examiner, † Cited by third party
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US2099160A (en) * 1935-10-23 1937-11-16 Du Pont Method and apparatus for drying
US2678504A (en) * 1951-06-14 1954-05-18 American Viscose Corp Apparatus for drying cut staple
US2927363A (en) * 1955-02-07 1960-03-08 Saco Lowell Shops Slasher
FR2007036A1 (en) * 1968-04-26 1970-01-02 Meoc Sa Engrais Organiqu Manufacturing a powder or granular mixture comprising - a small proportion of a component dispersed in

Cited By (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4676656A (en) * 1985-01-25 1987-06-30 Syntex (U.S.A.) Inc. Fluid handling apparatus and method
US4855601A (en) * 1986-10-30 1989-08-08 Societe Civile De Brevets, J.L.S. Method and device for automatic spectrometric analysis of a liquid, particularly of milk
US6827901B2 (en) 1990-03-02 2004-12-07 Ventana Medical Systems, Inc. Automated biological reaction apparatus
US5650327A (en) * 1990-03-02 1997-07-22 Ventana Medical Systems, Inc. Method for mixing reagent and sample mounted on a slide
US5654199A (en) * 1990-03-02 1997-08-05 Ventana Medical Systems, Inc. Method for rinsing a tissue sample mounted on a slide
US5654200A (en) * 1990-03-02 1997-08-05 Ventana Medical Systems, Inc. Automated slide processing apparatus with fluid injector
US7470541B2 (en) 1990-03-02 2008-12-30 Ventana Medical System, Inc. Automated biological reaction apparatus
US7118918B2 (en) * 1990-03-02 2006-10-10 Ventana Medical Systems, Inc. Automated biological reaction method
US6943029B2 (en) 1990-03-02 2005-09-13 Ventana Medical Systems, Inc. Automated biological reaction apparatus
US6284546B1 (en) 1994-06-16 2001-09-04 Dade Behring Marburg Gmbh Method and device for photodetection
US5948359A (en) * 1997-03-21 1999-09-07 Biogenex Laboratories Automated staining apparatus
US6093574A (en) * 1997-08-11 2000-07-25 Ventana Medical Systems Method and apparatus for rinsing a microscope slide
US20060190185A1 (en) * 1997-08-11 2006-08-24 Ventana Medical Systems, Inc. Memory management method and apparatus for automated biological reaction system
US20110168744A1 (en) * 1997-08-11 2011-07-14 Ventana Medical Systems, Inc. Method and apparatus for modifying pressure within a fluid dispenser
US8137619B2 (en) 1997-08-11 2012-03-20 Ventana Medical Systems, Inc. Memory management method and apparatus for automated biological reaction system
US20050135972A1 (en) * 1997-08-11 2005-06-23 Ventana Medical Systems, Inc. Method and apparatus for modifying pressure within a fluid dispenser
US6192945B1 (en) 1997-08-11 2001-02-27 Ventana Medical Systems, Inc. Fluid dispenser
US6945128B2 (en) 1997-08-11 2005-09-20 Ventana Medical Systems, Inc. Fluid dispenser
US6416713B1 (en) 1997-08-11 2002-07-09 Ventana Medical Systems, Inc. Fluid dispenser
US8147773B2 (en) 1997-08-11 2012-04-03 Ventana Medical Systems, Inc. Method and apparatus for modifying pressure within a fluid dispenser
US8609023B1 (en) 1997-08-11 2013-12-17 Ventana Medical Systems, Inc. Memory management method and apparatus for automated biological reaction system
US20020034456A1 (en) * 1997-08-11 2002-03-21 Anthony Ford Fluid dispenser
WO1999049295A1 (en) * 1998-03-24 1999-09-30 Biogenex Laboratories Automated staining apparatus
US20020110494A1 (en) * 2000-01-14 2002-08-15 Ventana Medical Systems, Inc. Method and apparatus for modifying pressure within a fluid dispenser
US7270785B1 (en) 2001-11-02 2007-09-18 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having fixed slide platforms
US7404927B2 (en) 2001-11-02 2008-07-29 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having fixed slide platforms
US11249095B2 (en) 2002-04-15 2022-02-15 Ventana Medical Systems, Inc. Automated high volume slide processing system
US7468161B2 (en) 2002-04-15 2008-12-23 Ventana Medical Systems, Inc. Automated high volume slide processing system
US9528918B2 (en) 2002-04-15 2016-12-27 Ventana Medical Systems, Inc. Automated high volume slide processing system
US8663991B2 (en) 2002-04-15 2014-03-04 Ventana Medical Systems, Inc. Automated high volume slide processing system
US10302665B2 (en) 2002-04-15 2019-05-28 Ventana Medical Systems, Inc. Automated high volume slide processing system
US7303725B2 (en) 2002-04-15 2007-12-04 Ventana Medical Systems, Inc. Automated high volume slide staining system
US11092611B2 (en) 2002-04-15 2021-08-17 Ventana Medical Systems, Inc. Automated high volume slide processing system
US8048373B2 (en) 2002-04-15 2011-11-01 Ventana Medical Systems, Inc. Automated high volume slide staining system
US7378055B2 (en) 2002-04-26 2008-05-27 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having fixed slide platforms
US8323984B2 (en) * 2002-12-19 2012-12-04 Beckman Coulter, Inc. Method and apparatus for mixing blood samples for cell analysis
US20040121484A1 (en) * 2002-12-19 2004-06-24 Tomas Betancourt Method and apparatus for mixing blood samples for cell analysis
US9229016B2 (en) 2002-12-20 2016-01-05 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US7758809B2 (en) 2002-12-20 2010-07-20 Dako Cytomation Denmark A/S Method and system for pretreatment of tissue slides
US8216512B2 (en) 2002-12-20 2012-07-10 Dako Denmark A/S Apparatus for automated processing biological samples
US8257968B2 (en) 2002-12-20 2012-09-04 Dako Denmark A/S Method and apparatus for automatic staining of tissue samples
US8298815B2 (en) 2002-12-20 2012-10-30 Dako Denmark A/S Systems and methods of sample processing and temperature control
US7937228B2 (en) 2002-12-20 2011-05-03 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US8386195B2 (en) 2002-12-20 2013-02-26 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US8394635B2 (en) 2002-12-20 2013-03-12 Dako Denmark A/S Enhanced scheduling sample processing system and methods of biological slide processing
US8529836B2 (en) 2002-12-20 2013-09-10 Dako Denmark A/S Apparatus for automated processing biological samples
US9599630B2 (en) 2002-12-20 2017-03-21 Dako Denmark A/S Method and apparatus for automatic staining of tissue samples
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US8663978B2 (en) 2002-12-20 2014-03-04 Dako Denmark A/S Method and apparatus for automatic staining of tissue samples
US8673642B2 (en) 2002-12-20 2014-03-18 Dako Denmark A/S Enhanced scheduling sample processing system and methods of biological slide processing
US8788217B2 (en) 2002-12-20 2014-07-22 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US8784735B2 (en) 2002-12-20 2014-07-22 Dako Denmark A/S Apparatus for automated processing biological samples
US10156580B2 (en) 2002-12-20 2018-12-18 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US8969086B2 (en) 2002-12-20 2015-03-03 Dako Denmark A/S Enhanced scheduling sample processing system and methods of biological slide processing
US7960178B2 (en) 2002-12-20 2011-06-14 Dako Denmark A/S Enhanced scheduling sample processing system and methods of biological slide processing
US7400983B2 (en) 2002-12-20 2008-07-15 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US9778273B2 (en) 2002-12-20 2017-10-03 Dako Denmark A/S Isolated communication sample processing system and methods of biological slide processing
US9156012B2 (en) 2004-06-11 2015-10-13 Roche Diagnostics Operations, Inc. Method and device for mixing samples on a support
EP1604734A2 (de) * 2004-06-11 2005-12-14 F. Hoffmann-La Roche Ag Verfahren und Vorrichtung zum Nachweis von Analyten
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Publication number Publication date
AU4679472A (en) 1974-03-28
FR2153083A1 (xx) 1973-04-27
AU464171B2 (en) 1975-08-21
FR2153083B1 (xx) 1976-08-13
DE2245711A1 (de) 1973-03-29
IT975006B (it) 1974-07-20
CA976954A (en) 1975-10-28
LU66096A1 (xx) 1973-01-17
BE788877A (fr) 1973-01-02
NL7212537A (xx) 1973-03-20
SE392170B (sv) 1977-03-14

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