US3820534A - Device for promoting the formation of bone substance - Google Patents
Device for promoting the formation of bone substance Download PDFInfo
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- US3820534A US3820534A US00241728A US24172872A US3820534A US 3820534 A US3820534 A US 3820534A US 00241728 A US00241728 A US 00241728A US 24172872 A US24172872 A US 24172872A US 3820534 A US3820534 A US 3820534A
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- bone
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- marrow nail
- coil
- electrode
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 58
- 239000000126 substance Substances 0.000 title claims description 9
- 230000015572 biosynthetic process Effects 0.000 title claims description 7
- 230000001737 promoting effect Effects 0.000 title description 2
- 210000004394 hip joint Anatomy 0.000 claims description 11
- 210000000689 upper leg Anatomy 0.000 claims description 6
- 210000002436 femur neck Anatomy 0.000 claims description 3
- 239000000696 magnetic material Substances 0.000 claims description 2
- 210000002391 femur head Anatomy 0.000 claims 1
- 239000002184 metal Substances 0.000 description 7
- 238000004804 winding Methods 0.000 description 5
- 206010017076 Fracture Diseases 0.000 description 4
- 230000005291 magnetic effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000004568 cement Substances 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 208000010392 Bone Fractures Diseases 0.000 description 2
- 229910000684 Cobalt-chrome Inorganic materials 0.000 description 2
- 229910045601 alloy Inorganic materials 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000010952 cobalt-chrome Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000011164 ossification Effects 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 208000020084 Bone disease Diseases 0.000 description 1
- 208000024779 Comminuted Fractures Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000006735 Periostitis Diseases 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003302 ferromagnetic material Substances 0.000 description 1
- 230000005021 gait Effects 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000003460 periosteum Anatomy 0.000 description 1
- 230000009894 physiological stress Effects 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- IHQKEDIOMGYHEB-UHFFFAOYSA-M sodium dimethylarsinate Chemical class [Na+].C[As](C)([O-])=O IHQKEDIOMGYHEB-UHFFFAOYSA-M 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 230000007998 vessel formation Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2821—Bone stimulation by electromagnetic fields or electric current for enhancing ossification
Definitions
- a splint for fixing a bone structure in position is in the fonn of a marrow nail, of which at least a part is con- 1 structed to serve as an electrode.
- the electrode is connected to a first terminal end of a pick-up coil.
- the second terminal end of the coil is connected to a sec- 0nd electrode which may be also attached to the marrow nail or is fixed to a belt-like carrier adapted to be tightened around the bone structure.
- the present invention relates to a device for promting the formation of bone substance adjacent to the bone of a living organism, comprising a splint for fixing the bone in position and provided with at least one pick-up coil, whose two terminal ends are connected with at least one electrode adapted for application to the bone structure.
- the part of the marrow nail serving as an electrode is provided with at least one counter-electrode, which is arranged on a belt-like carrier, which has a closure'whieh enables it to exert a circumferential force on the bone or its part into which the marrow nail has been introduced.
- FIG. 1 shows a marrow nail inserted into a broken bone, in accordance with one embodiment of the invention.
- FIG. 2 shows a marrow nail arranged in a fractured bone in accordance with a second embodiment of the invention.
- FIG. 3 shows a partly cut-away view of the marrow nail in accordance with FIG. 2.
- FIG. 4 is a partial view of a fractured bone with a device in accordance with a further embodiment of the invention.
- FIG. 5 is a plan view of a pick-up coil of the device in accordance with FIG. 4.
- FIG. 6 shows on an enlarged scale the zone denoted Z in FIG. 4.
- FIG. 7a is a view of a cerclage for a device of the type indicated in FIG. 4.
- FIG. 7b is a front view of the fastener used with the cerclage of FIG. 7a.
- FIG. 7c is a side view of the fastener of FIG. 7b.
- FIG. 7d is a side view of a counter-electrode of FIG.
- FIG. 8 is a perspective view of a cerclage in accordance with FIG. 7 arranged on a fractured bone.
- FIG. 9 shows a cross-section of the arrangement shown in FIG. 8.
- FIGS. 10a and 10b show part of a hip-joint prosthesis from the broad and narrow sides respectivelylin accordance. with an embodiment of the invention.
- FIGS. 1 la and 11b are views generally corresponding to FIGS. 10a and 10b of a further embodiment in accordance with the invention.
- FIG. I shows a fractured human femur, which is fixed in position by means of a Kt'mtscher or marrow nail 14 inserted into the marrow cavity 12 which has been bored out.
- marrow nail 14 is made in a conventional manner of a piece of sheet metal of cobalt-chrome alloy, which is bent so as to have the shape of a slotted tube.
- a middle section of the marrow nail is provided with insulating material 16, on which two wire or strip-like electrodes 18 and 20 are arranged.
- the electrodes are preferably placed on opposite sides of the marrow nail adjacent to the fractures 22. They are connected with the ends of a wire winding of a pick-up coil 24, which is arranged on a magnetic core 26 inside the marrow nail l4.
- the pick-up coil is placed in an alternating magnetic field, which is produced by means of a cylindrical coil 28 for example, as described in patent application Ser. No. 26,809, now US. Pat. No. 3,745,995 issued on July I7, 1973 to Werner Kraus.
- the alternating magnetic field should have a low frequency, for example up to approximately 60 Hz and its pulses should not have steep flanks.
- FIG. 2 shows a further embodiment of a marrow nail in accordance with the invention.
- This marrow nail 14 again has an insulated section 16', on which two substantially semi-cylindrical electrodes 18', 20 are arranged which are insulated from each other and from the actual marrow nail 14'.
- the electrodes have electrically conducting surfaces, which extend over the greater part of the length of the marrow nail l4.
- the marrow nail 14 itself is tubular and consists of a non-ferromagnetic material. In its interior a pickup coil 24' is arranged and the ends of its wire winding are connected with the electrodes 18 and 20 respectively.
- the whole marrow nail 14" serves as an electrode and cooperates with counter-electrodes 20a to 20d, which are arranged on the outer surface of the fractured bone 10 and are held in position by beltlike straps 30.
- the marrow nail 14" is connected via a conductor 32 with the one terminal of a pick-up coil 24", whose other terminal is connected with the electrodes a and 20d via suitable lines.
- the pick-up coil 24" is shown in plan view in FIG. 5. It can be embedded in a fastener 34, which serves to hold together the overlapping ends of the belt'like straps 30.
- the straps 30 are ribbed on both sides as is shown in FIG.
- FIG. 7 shows a further embodiment of a beltlike electrode carrier.
- the electrode carrier constructed in the form of a cerclage consists of a part 40.
- the part 40 of the plastics material has a relatively broad initial part 42, which is provided with a hole 44 and cooperates with a fastener 46 in the form of an U-shaped piece of metal sheet, which is held by means of a screw (not shown) extending through the hole 44 and a corresponding hole in the piece of sheet metal 46.
- the initial part 42 is connected with two narrow belt-like parts 48 which are preferably ribbed in the manner shown in FIG. 6.
- sliding electrode arrangements 50 are arranged, of which one is shown in section at the bottom of FIG. 7 on the right-hand side.
- the electrode arrangements 50 comprise the actual electrode 20", which rests in a retaining means 52, made of plastics material, which can be slid on the associated belt-like part 48. As long as the belt-like parts are not under tension the electrode arrangement 50 can be displaced in the longitudinal direction of the belt-like parts 48. When the electrode is tightened the holding means 52 slides into the ribs and the electrode becomes fixed at the position intended.
- FIGS. 8 and 9 shows a device in accordance with FIG. 7 tightened around a bone.
- the pick-up coil 24 connected with the electrodes is fixed in the fastener device 46. It would naturally be possible for the pickup coil to be arranged in the interior of the marrow nail 14 holding the bone in position, as has ben explained with reference to FIGS. 1 and 3.
- the marrow nail can also be made of a material which is absorbed by the body. for example animal bone freed of protein. In this case no separate insulating device for bringing about electrical separation of the electrodes would have to be provided.
- FIGS. 10 and 11 show two embodiments or marrow nails which form part of hip joint prosthesis, that is to say an artificial human hip-joint.
- the hip joint prosthesis in accordance with FIG. 10 is constructed using a conventional cobalt-chrome alloy and includes a substantially spherical head 60, which adjoins the dagger-like shank 62 (FIG. 10) which is inserted in a conventional manner from above into the open marrow cavity to replace the injured or diseased hip-joint in a conventional manner.
- the replacement of the head of the femur is carried out more particularly in the case of fractures of the neck of the femur in the case of elderly persons and in advanced cases of Arthrosis deformans, a degenerative joint and bone disease.
- the hip joint prosthesis has been fixed in position in the marrow cavity using a particular cement.
- a substantial disadvantage of this manner of fixation of the prosthesis in the femur resides in that the further decomposition of the bone is not retarded by the replacement metal joint so that in the course of time there is a loss of frictional connection between the bone and the cement.
- the prosthesis then becomes loose and this leads to impairment of the gait and pain.
- protheses have involved a further operation being carried out as a matter of course after some years.
- the shank 62 (FIG. 10) forming the marrow nail of the hip-joint prosthesis comprises for this purpose a pickup coil 24, which is preferably provided with a magnetizeable core of magnetically soft material.
- the shank 62 can for this purpose comprise a channel-like recess whose opening 64 is only shown diagrammatically in FIG. 10.
- the oneend of the wire winding of the pickup coil is connected with an electrode 18m which is insulated from the shank 62 and is arranged approximately in the center of the shank, while the other end of the wire winding is connectd with two electrodes 18n and 18p, which are insulated from the shank 62 and are arranged at its upper and lower end respectively.
- elongated strip-like electrodes are arranged on the two opposite broad sides of the shank 62', only one electrode, 18', being shown in FIG. 11.
- the electrodes are insulated again from the shank 62' which is made of metal and are connected with the ends of the wire winding of a pick-up coil (not shown) which is accommodated in the shank 62.
- the shank can itself be used as an electrode and cooperate with counter-electrodes, which are arranged in an insulated fashion in the shank or are located on the cerclages extending round the bone, as was described with reference to FIGS. 4 to 9.
- alternating currents are induced in the pick-up coil as explained in the abovementioned patent application. These alternating currents encourage the formation of bone and vessels, and newly formed bone substance grows around the shank 62 or 62', respectively, so that a firm fit is ensured.
- the alternating magnetic field inducing the alternating currents also contributes to bone and vessel formation. For the fixation of the prosthesis therefore at the most only small quantities of cement are necessary.
- the shape of .the shank 62 and 62' which has alterattachment of the prosthesis nating expanded and drawn-in parts, encourages a firm attachment in the, marrow cavity of the bone owing to bone growth;
- v r v 1 A device for assisting in formation of bone substance adjacentto the bone of a living organism, coinprising: a splint for fixing the boneinposition and-including a marrow nail;'at least one pick-up coil associated with the splint and having two terminals and said coil being adapted to be coupled to a signal generating means for establishing within said vcoil an a.c. current;
- an electrode, assembly connected to said terminals-and adapted to be connected to the bone; and, the marrow nail having an elongated main part on which there is embeddedalong one surface thereof at least a portion of the electrode assembly which is insulated at least a with respect to the main part and has an exposed electrically conducting surface.
- the electrode, assembly includes two electrodes, insulated from each other, and embedded in opposite sides of the main part.
- a device in accordance with claim 2 in which the electrodes have elongated surfaces, which run along he-longitudinal axisof the main part of the marrow 1 [4.
- a device for assisting information of bone substance adjacent to the bone of a living organism comprising: a splint for fixing the bone in position and including a marrow nail; at least one pick-up coil associated with the splint and having two terminals and said coil being adapted to be coupled to a signal generating means for establishing within said coil an ac. current;
- an electrode assembly connected to said terminals and adapted to be connected to the bone; and, at least a portion of the marrow nail forming at least a portion of the electrode assembly; wherein the electrode assembly includes at least one counter-electrode which is mounted on a belt-like carrier, the part of the marrow nail forming a portion of the electrode assembly is adapted to cooperate with said counter-electrode, and
- the carrier includes a fastener for tightening it around the fractured bone encompassing the marrow nail.
- the belt-like carrier comprises a straplike part which on .both sides is ribbed in the transverse direction
- the electrode assembly includes a plurality of electrodes which are arranged spaced apart along the longitudinal axis of the marrow'nail.
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
A splint for fixing a bone structure in position is in the form of a marrow nail, of which at least a part is constructed to serve as an electrode. The electrode is connected to a first terminal end of a pick-up coil. The second terminal end of the coil is connected to a second electrode which may be also attached to the marrow nail or is fixed to a belt-like carrier adapted to be tightened around the bone structure.
Description
United States Patent 1191 Kraus et al.
[ June 28, 1974 DEVICE FOR PROMOTING THE C FORMATION OF BONE SUBSTANCE Foreign Application Priority Data Apr. 6, I97] Germany.... 21 I686) us. 01. 128/82.l, 3/1 Int. Cl. A6ln Fieldof Search 128/821, 92; 3/1 1 References Cited UNITED STATES PATENTS 11/1971 Bokros l28/9 2 B1 6/1972 Bosacco 128/92 D OTHER PUBLICATIONS Effects of Electric Currents on Bone in Vivo, by Bassett et al., Nature, Nov. 14, 1964, pp. 652-654.
The Effect of Direct Current 0n Bone, by F riedenberg et al., Surgery, Gynecology & Obstetrics, July, 1968, pp. 97-102.
Bioelectric Potentials in Bone, by Friedenberg et al., Journal of Bone & Joint Surgery, July, 1966, pp. 915-923.
Primary ExaminerRichard A. Gaudet Assistant ExaminerJ. Yasko Attorney, Agent, or Firm-Spencer & Kaye [571 ABSTRACT A splint for fixing a bone structure in position is in the fonn of a marrow nail, of which at least a part is con- 1 structed to serve as an electrode. The electrode is connected to a first terminal end of a pick-up coil. The second terminal end of the coil is connected to a sec- 0nd electrode which may be also attached to the marrow nail or is fixed to a belt-like carrier adapted to be tightened around the bone structure.
129 13; REQWJPA JEEEQ PATENTED JUN? 8 I974 SHEET 5 0F 6 Fig.10b
Fig.10c1
PATENTEDJUN28 I974 sum 6 or 6 Fig.1]
Fig.11c1
REFERENCE TO COPENDING APPLICATION The present application describes a further develop ment of the invention described in Application Ser. No. 26,809,, now US. Pat. No. 3,745,995, issued July 17, I973.
BACKGROUND OF INVENTION 1. Field to which invention relates The present invention relates to a device for promting the formation of bone substance adjacent to the bone of a living organism, comprising a splint for fixing the bone in position and provided with at least one pick-up coil, whose two terminal ends are connected with at least one electrode adapted for application to the bone structure.
2. The prior art The fixing in position of a broken bone by means of a splint with a metal plate screwed onto the outer surface of the bone has the disadvantage that the metal plate brings about an unnatural distribution of forces in the bone during healing and this may lead to refracture of the bone. The plate screwed on the bone practically cuts out the curative physiological stress and load on the bone during healing. Since at the present time comminuted fractures are becoming more and more numerous, it is often no longer possible to fix small bone fragments in position by means of plates and screws so that as a result osteogenesis is rendered uncertain.
Therefore, for some time a so-called Kiintscher or marrow nail has been employed which is inserted into a hole bored into the marrow cavity. The endosteum and the blood vessels contained in it are destroyed in this method so that the healing process is delayed. As a result in the case of multiple or chip fractures such a marrow nail can be used only to a very limited extent as it does not support the small bone fragments in the case of such chip fractures. Although there has been a previous proposal to fix such cips in position by socalled cerclages, that is to say by means of wires which are laid around the chips and then drawn together, the
substantial forces exerted by the wires on the bone lead to a contraction of the periosteum and block the blood vessels contained in it. Such wire cerclages cannot ensure that proper osteosynthesis takes place.
SUMMARY OF INVENTION invention the part of the marrow nail serving as an electrode is provided with at least one counter-electrode, which is arranged on a belt-like carrier, which has a closure'whieh enables it to exert a circumferential force on the bone or its part into which the marrow nail has been introduced.
Further developments of the invention will be described in what follows.
LIST OF SEVERAL VIEWS OF DRAWINGS Embodiments of the invention will now be described with reference to the accompanying drawings in more detail.
FIG. 1 shows a marrow nail inserted into a broken bone, in accordance with one embodiment of the invention.
FIG. 2 shows a marrow nail arranged in a fractured bone in accordance with a second embodiment of the invention.
FIG. 3 shows a partly cut-away view of the marrow nail in accordance with FIG. 2.
FIG. 4 is a partial view of a fractured bone with a device in accordance with a further embodiment of the invention.
FIG. 5 is a plan view of a pick-up coil of the device in accordance with FIG. 4.
FIG. 6 shows on an enlarged scale the zone denoted Z in FIG. 4.
FIG. 7a is a view of a cerclage for a device of the type indicated in FIG. 4.
FIG. 7b is a front view of the fastener used with the cerclage of FIG. 7a.
FIG. 7c is a side view of the fastener of FIG. 7b.
FIG. 7d is a side view of a counter-electrode of FIG.
FIG. 8 is a perspective view of a cerclage in accordance with FIG. 7 arranged on a fractured bone.
FIG. 9 shows a cross-section of the arrangement shown in FIG. 8.
FIGS. 10a and 10b show part of a hip-joint prosthesis from the broad and narrow sides respectivelylin accordance. with an embodiment of the invention.
FIGS. 1 la and 11b are views generally corresponding to FIGS. 10a and 10b of a further embodiment in accordance with the invention.
DESCRIPTION OF PREFERRED EMBODIMENTS As an example of a fractured bone FIG. I shows a fractured human femur, which is fixed in position by means of a Kt'mtscher or marrow nail 14 inserted into the marrow cavity 12 which has been bored out. The
marrow nail 14 is made in a conventional manner of a piece of sheet metal of cobalt-chrome alloy, which is bent so as to have the shape of a slotted tube. A middle section of the marrow nail is provided with insulating material 16, on which two wire or strip- like electrodes 18 and 20 are arranged. The electrodes are preferably placed on opposite sides of the marrow nail adjacent to the fractures 22. They are connected with the ends of a wire winding of a pick-up coil 24, which is arranged on a magnetic core 26 inside the marrow nail l4. During treatment of the patient the pick-up coil is placed in an alternating magnetic field, which is produced by means of a cylindrical coil 28 for example, as described in patent application Ser. No. 26,809, now US. Pat. No. 3,745,995 issued on July I7, 1973 to Werner Kraus. In particular the alternating magnetic field should have a low frequency, for example up to approximately 60 Hz and its pulses should not have steep flanks.
FIG. 2 shows a further embodiment of a marrow nail in accordance with the invention. This marrow nail 14 again has an insulated section 16', on which two substantially semi-cylindrical electrodes 18', 20 are arranged which are insulated from each other and from the actual marrow nail 14'. The electrodes have electrically conducting surfaces, which extend over the greater part of the length of the marrow nail l4.
The marrow nail 14 itself is tubular and consists of a non-ferromagnetic material. In its interior a pickup coil 24' is arranged and the ends of its wire winding are connected with the electrodes 18 and 20 respectively.
In the case of the embodiment in accordance with FIGS. 4, 5, and 6 the whole marrow nail 14" serves as an electrode and cooperates with counter-electrodes 20a to 20d, which are arranged on the outer surface of the fractured bone 10 and are held in position by beltlike straps 30. The marrow nail 14" is connected via a conductor 32 with the one terminal of a pick-up coil 24", whose other terminal is connected with the electrodes a and 20d via suitable lines. The pick-up coil 24" is shown in plan view in FIG. 5. It can be embedded in a fastener 34, which serves to hold together the overlapping ends of the belt'like straps 30. Preferably the straps 30 are ribbed on both sides as is shown in FIG. 6, so that firstly a slipping of the overlapping ends in relation to each other is prevented and secondly vessels, which run between the straps 30 and the bone 10, can slip into the grooves between the ribs and are not pinched. FIG. 7 shows a further embodiment of a beltlike electrode carrier. The electrode carrier constructed in the form of a cerclage consists of a part 40.
of a plastics material, for example polytetrafluoroethylene, which can be reinforced by wires or glass fibers. The part 40 of the plastics material has a relatively broad initial part 42, which is provided with a hole 44 and cooperates with a fastener 46 in the form of an U-shaped piece of metal sheet, which is held by means of a screw (not shown) extending through the hole 44 and a corresponding hole in the piece of sheet metal 46. The initial part 42 is connected with two narrow belt-like parts 48 which are preferably ribbed in the manner shown in FIG. 6. On the belt-like or straplike parts 48 sliding electrode arrangements 50 are arranged, of which one is shown in section at the bottom of FIG. 7 on the right-hand side. The electrode arrangements 50 comprise the actual electrode 20", which rests in a retaining means 52, made of plastics material, which can be slid on the associated belt-like part 48. As long as the belt-like parts are not under tension the electrode arrangement 50 can be displaced in the longitudinal direction of the belt-like parts 48. When the electrode is tightened the holding means 52 slides into the ribs and the electrode becomes fixed at the position intended.
FIGS. 8 and 9 shows a device in accordance with FIG. 7 tightened around a bone. The pick-up coil 24 connected with the electrodes is fixed in the fastener device 46. It would naturally be possible for the pickup coil to be arranged in the interior of the marrow nail 14 holding the bone in position, as has ben explained with reference to FIGS. 1 and 3.
The marrow nail can also be made of a material which is absorbed by the body. for example animal bone freed of protein. In this case no separate insulating device for bringing about electrical separation of the electrodes would have to be provided.
FIGS. 10 and 11 show two embodiments or marrow nails which form part of hip joint prosthesis, that is to say an artificial human hip-joint.
The hip joint prosthesis in accordance with FIG. 10 is constructed using a conventional cobalt-chrome alloy and includes a substantially spherical head 60, which adjoins the dagger-like shank 62 (FIG. 10) which is inserted in a conventional manner from above into the open marrow cavity to replace the injured or diseased hip-joint in a conventional manner.
The replacement of the head of the femur is carried out more particularly in the case of fractures of the neck of the femur in the case of elderly persons and in advanced cases of Arthrosis deformans, a degenerative joint and bone disease. Up till now the hip joint prosthesis has been fixed in position in the marrow cavity using a particular cement. A substantial disadvantage of this manner of fixation of the prosthesis in the femur resides in that the further decomposition of the bone is not retarded by the replacement metal joint so that in the course of time there is a loss of frictional connection between the bone and the cement. The prosthesis then becomes loose and this leads to impairment of the gait and pain. In the past such protheses have involved a further operation being carried out as a matter of course after some years.
In the case of the hip-joint prothesis in accordance with the invention as shown in FIGS. 10 and 11 the attachment of the prosthesis to the bone substance is promoted by the influence of low frequency alternating currents which gradually vary.
The shank 62 (FIG. 10) forming the marrow nail of the hip-joint prosthesis comprises for this purpose a pickup coil 24, which is preferably provided with a magnetizeable core of magnetically soft material. The shank 62 can for this purpose comprise a channel-like recess whose opening 64 is only shown diagrammatically in FIG. 10. The oneend of the wire winding of the pickup coil is connected with an electrode 18m which is insulated from the shank 62 and is arranged approximately in the center of the shank, while the other end of the wire winding is connectd with two electrodes 18n and 18p, which are insulated from the shank 62 and are arranged at its upper and lower end respectively.
In the case of the embodiment in accordance with FIG. 11 elongated strip-like electrodes are arranged on the two opposite broad sides of the shank 62', only one electrode, 18', being shown in FIG. 11. The electrodes are insulated again from the shank 62' which is made of metal and are connected with the ends of the wire winding of a pick-up coil (not shown) which is accommodated in the shank 62.
Alternatively the shank can itself be used as an electrode and cooperate with counter-electrodes, which are arranged in an insulated fashion in the shank or are located on the cerclages extending round the bone, as was described with reference to FIGS. 4 to 9.
After the hip-joint prosthesis in accordance with FIG. 10 or FIG. 11 has been introduced into the marrow cavity of the femur, alternating currents are induced in the pick-up coil as explained in the abovementioned patent application. These alternating currents encourage the formation of bone and vessels, and newly formed bone substance grows around the shank 62 or 62', respectively, so that a firm fit is ensured. The alternating magnetic field inducing the alternating currents also contributes to bone and vessel formation. For the fixation of the prosthesis therefore at the most only small quantities of cement are necessary.
nail. a
, -This subsequent treatment then brings about growth leading to a firm renewed to the bone.
The shape of .the shank 62 and 62', which has alterattachment of the prosthesis nating expanded and drawn-in parts, encourages a firm attachment in the, marrow cavity of the bone owing to bone growth;
Whatwe claim is: v r v 1. A device for assisting in formation of bone substance adjacentto the bone of a living organism, coinprising: a splint for fixing the boneinposition and-including a marrow nail;'at least one pick-up coil associated with the splint and having two terminals and said coil being adapted to be coupled to a signal generating means for establishing within said vcoil an a.c. current;
, an electrode, assembly connected to said terminals-and adapted to be connected to the bone; and, the marrow nail having an elongated main part on which there is embeddedalong one surface thereof at least a portion of the electrode assembly which is insulated at least a with respect to the main part and has an exposed electrically conducting surface.
2.vAdevice in accordance with claim 1, wherein the electrode, assembly includes two electrodes, insulated from each other, and embedded in opposite sides of the main part.
3. A device in accordance with claim 2,in whichthe electrodes have elongated surfaces, which run along he-longitudinal axisof the main part of the marrow 1 [4. A device in accordance with claim 1, wherein the nail, which is made of non-magnetic material.
5. A device in accordance with claim 1, wherein the marrow nail forms a part of a femur prosthesis and at therend has a hip-joint femurfhead, or a femur neck prosthesis V v 6. device in accordance with claim Sywherein the marrow nail has alternating expanded and drawn-in "portions along its longitudinal axis.
7. A device for assisting information of bone substance adjacent to the bone of a living organism, comprising: a splint for fixing the bone in position and including a marrow nail; at least one pick-up coil associated with the splint and having two terminals and said coil being adapted to be coupled to a signal generating means for establishing within said coil an ac. current;
an electrode assembly connected to said terminals and adapted to be connected to the bone; and, at least a portion of the marrow nail forming at least a portion of the electrode assembly; wherein the electrode assembly includes at least one counter-electrode which is mounted on a belt-like carrier, the part of the marrow nail forming a portion of the electrode assembly is adapted to cooperate with said counter-electrode, and
, the carrier includes a fastener for tightening it around the fractured bone encompassing the marrow nail.
8. A device in accordance with claim 7, wherein that I the belt-like carrier comprises a straplike part which on .both sides is ribbed in the transverse direction,
, 9. A device in accordance with claim 7, wherein the carrier has a broad initial part adapted to cooperate "with the fastener and this broad part adjoins two nar "row strap-like parts which are spaced apart.
10. A device in accordance with claim 7, wherein the pick-up coil is accommodated in the fastener.
l 1. A-device in'acco'rdance with claim 7, wherein the counter electrode is arranged on the belt-like carrier so pick-up coil is arranged in the main part of the marrow that it can be slid along the longitudinal axis of the carrier. v I
12. A device in accordance with claim 1, wherein the electrode assembly includes a plurality of electrodes which are arranged spaced apart along the longitudinal axis of the marrow'nail.
Claims (12)
1. A device for assisting in formation of bone substance adjacent to the bone of a living organism, comprising: a splint for fixing the bone in position and including a marrow nail; at least one pick-up coil associated with the splint and having two terminals and said coil being adapted to be coupled to a signal generating means for establishing within said coil an a.c. current; an electrode assembly connected to said terminals and adapted to be connected to the bone; and, the marrow nail having an elongated main part on which there is embedded along one surface thereof at least a portion of the electrode assembly which is insulated at least with respect to the main part and has an exposed electrically conducting surface.
2. A device in accordance with claim 1, wherein the electrode assembly includes two electrodes, insulated from each other, and embedded in opposite sideS of the main part.
3. A device in accordance with claim 2, in which the electrodes have elongated surfaces, which run along the longitudinal axis of the main part of the marrow nail.
4. A device in accordance with claim 1, wherein the pick-up coil is arranged in the main part of the marrow nail, which is made of non-magnetic material.
5. A device in accordance with claim 1, wherein the marrow nail forms a part of a femur prosthesis and at the end has a hip-joint femur head, or a femur neck prosthesis.
6. A device in accordance with claim 5, wherein the marrow nail has alternating expanded and drawn-in portions along its longitudinal axis.
7. A device for assisting in formation of bone substance adjacent to the bone of a living organism, comprising: a splint for fixing the bone in position and including a marrow nail; at least one pick-up coil associated with the splint and having two terminals and said coil being adapted to be coupled to a signal generating means for establishing within said coil an a.c. current; an electrode assembly connected to said terminals and adapted to be connected to the bone; and, at least a portion of the marrow nail forming at least a portion of the electrode assembly; wherein the electrode assembly includes at least one counter-electrode which is mounted on a belt-like carrier, the part of the marrow nail forming a portion of the electrode assembly is adapted to cooperate with said counter-electrode, and the carrier includes a fastener for tightening it around the fractured bone encompassing the marrow nail.
8. A device in accordance with claim 7, wherein that the belt-like carrier comprises a straplike part which on both sides is ribbed in the transverse direction.
9. A device in accordance with claim 7, wherein the carrier has a broad initial part adapted to cooperate with the fastener and this broad part adjoins two narrow strap-like parts which are spaced apart.
10. A device in accordance with claim 7, wherein the pick-up coil is accommodated in the fastener.
11. A device in accordance with claim 7, wherein the counter electrode is arranged on the belt-like carrier so that it can be slid along the longitudinal axis of the carrier.
12. A device in accordance with claim 1, wherein the electrode assembly includes a plurality of electrodes which are arranged spaced apart along the longitudinal axis of the marrow nail.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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DE19712116869 DE2116869C2 (en) | 1970-04-06 | 1971-04-06 | Bone and biological tissue growth promotion appts. - uses flat coil for application of LF current from generator |
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US3820534A true US3820534A (en) | 1974-06-28 |
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Application Number | Title | Priority Date | Filing Date |
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US00241728A Expired - Lifetime US3820534A (en) | 1971-04-06 | 1972-04-06 | Device for promoting the formation of bone substance |
US241727A Expired - Lifetime US3890953A (en) | 1971-04-06 | 1972-04-06 | Electrical apparatus generating a low frequency, alternating magnetic field for promoting the growth of bone and other body tissues |
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Application Number | Title | Priority Date | Filing Date |
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US241727A Expired - Lifetime US3890953A (en) | 1971-04-06 | 1972-04-06 | Electrical apparatus generating a low frequency, alternating magnetic field for promoting the growth of bone and other body tissues |
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US (2) | US3820534A (en) |
JP (3) | JPS5839547B1 (en) |
AT (2) | AT316729B (en) |
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GB (2) | GB1393701A (en) |
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Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3964473A (en) * | 1972-09-21 | 1976-06-22 | Telectronics Pty. Limited | Bone prosthesis |
US4195367A (en) * | 1976-03-19 | 1980-04-01 | Werner Kraus | Long-term endoprosthesis |
US4216548A (en) * | 1976-03-19 | 1980-08-12 | Werner Kraus | Long-term endoprosthesis |
US4306564A (en) * | 1977-09-22 | 1981-12-22 | Werner Kraus | Electrification attachment for an osteo-synthesis implantate |
US4549547A (en) * | 1982-07-27 | 1985-10-29 | Trustees Of The University Of Pennsylvania | Implantable bone growth stimulator |
US4611597A (en) * | 1982-11-03 | 1986-09-16 | Werner Kraus | Implantable device for the stimulation of bone growth |
EP0781532A2 (en) | 1995-11-30 | 1997-07-02 | Christoph Rehberg | Implantable device with inner electrode |
US6018094A (en) * | 1995-02-06 | 2000-01-25 | Biomedical Enterprises, Inc. | Implant and insert assembly for bone and uses thereof |
US6143035A (en) * | 1999-01-28 | 2000-11-07 | Depuy Orthopaedics, Inc. | Implanted bone stimulator and prosthesis system and method of enhancing bone growth |
WO2001095817A1 (en) * | 2000-06-13 | 2001-12-20 | Hyde Edward R Jr | Magnetic array implant and prosthesis |
US6387096B1 (en) * | 2000-06-13 | 2002-05-14 | Edward R. Hyde, Jr. | Magnetic array implant and method of treating adjacent bone portions |
WO2002102457A1 (en) * | 2001-06-14 | 2002-12-27 | Georges Vanroy | Apparatus for applying an electromagnetic field to a living body |
US20030187510A1 (en) * | 2001-05-04 | 2003-10-02 | Hyde Edward R. | Mobile bearing prostheses |
US20030195633A1 (en) * | 2001-05-04 | 2003-10-16 | Hyde Edward R. | Magnetic array implant and prosthesis insert |
EP1371388A2 (en) * | 1990-05-04 | 2003-12-17 | Bio-Magnetic Therapy Systems, Inc. | Apparatus for treating a body organ with magnetic field |
US20040024400A1 (en) * | 1994-05-27 | 2004-02-05 | Michelson Gary Karlin | Method for the delivery of electrical current to promote bone growth between adjacent bone masses |
WO2005044375A1 (en) | 2003-11-11 | 2005-05-19 | Igea S.R.L. | Electromagnetic field stimulator device for anatomic biophysical chondroprotection |
US20060052782A1 (en) * | 2004-06-07 | 2006-03-09 | Chad Morgan | Orthopaedic implant with sensors |
US20060190080A1 (en) * | 2005-02-04 | 2006-08-24 | Intellistem Orthopaedic | Implanted prosthetic device |
US20100152864A1 (en) * | 2008-12-15 | 2010-06-17 | University Of Utah | Osseointegrated implant with electrical stimulation |
US20120165950A1 (en) * | 2010-12-23 | 2012-06-28 | Rainer Baumgart | Implantable prosthesis for replacing a human hip or knee joint and the adjoining bone sections |
US8679189B1 (en) * | 2013-02-11 | 2014-03-25 | Amendia Inc. | Bone growth enhancing implant |
EP2797525A4 (en) * | 2011-12-27 | 2015-11-04 | Richard Rogachefsky | Orthopedic fixation device with magnetic field generator |
US10335282B2 (en) | 2016-02-09 | 2019-07-02 | Richard A. Rogachefsky | Magnetic joint replacement |
US10838406B2 (en) | 2013-02-11 | 2020-11-17 | The Aerospace Corporation | Systems and methods for the patterning of material substrates |
US11596803B2 (en) | 2018-08-02 | 2023-03-07 | Richard A. Rogachefsky | Orthopedic treatment device with electromagnetic field generator |
Families Citing this family (123)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE7422801U (en) * | 1974-07-04 | 1977-04-07 | Kraus, Werner, Dipl.-Ing., 8000 Muenchen | Solenoil coil for an electromagnetic therapy device |
US4056097A (en) * | 1976-03-15 | 1977-11-01 | Joachim Adolf Maass | Contactless stimulus transducer |
DE2619650C3 (en) * | 1976-05-04 | 1985-06-05 | Friedrichsfeld Gmbh, Steinzeug- Und Kunststoffwerke, 6800 Mannheim | Dental implant |
US4266532A (en) * | 1976-11-17 | 1981-05-12 | Electro-Biology, Inc. | Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment |
US4315503A (en) * | 1976-11-17 | 1982-02-16 | Electro-Biology, Inc. | Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment |
US4105017A (en) * | 1976-11-17 | 1978-08-08 | Electro-Biology, Inc. | Modification of the growth repair and maintenance behavior of living tissue and cells by a specific and selective change in electrical environment |
US4142521A (en) * | 1976-12-23 | 1979-03-06 | Hoffmann-La Roche Inc. | Electrostatic soft tissue wound repair enhancement |
US4154246A (en) * | 1977-07-25 | 1979-05-15 | Leveen Harry H | Field intensification in radio frequency thermotherapy |
US4186729A (en) * | 1977-11-25 | 1980-02-05 | Donald L. Morton & Associates | Deep heating electrode |
US4537181A (en) * | 1978-12-05 | 1985-08-27 | Hydromagnetics, Inc. | Hydromagnetic apparatus for non-surgical in vivo removal of calcium deposits |
DE3071892D1 (en) * | 1980-10-03 | 1987-02-26 | Henning Rosengart | Electromedical treatment apparatus |
US4506673A (en) * | 1982-10-18 | 1985-03-26 | Rorer Group Inc. | Therapeutic treatment within joint capsules of the body |
US5269746A (en) * | 1982-12-20 | 1993-12-14 | Jacobson Jerry I | Therapeutic treatment of mammals for epilepsy and Parkinson's disease |
US5366435A (en) * | 1982-12-20 | 1994-11-22 | Jacobson Jerry I | Therapeutic treatment of mammals |
JPS6024121A (en) * | 1983-07-16 | 1985-02-06 | 林原 健 | Enhancement of productibity of animal and vegetable |
CA1192261A (en) * | 1984-02-29 | 1985-08-20 | David J. Stewart | Magnetic biological device |
EP0181053A3 (en) * | 1984-09-12 | 1988-07-20 | Irt, Inc. | Pulse electro-magnetic field therapy device with auto biased circuit and method for use |
US4602638A (en) * | 1984-10-03 | 1986-07-29 | Eddie Adams | Apparatus and method for invasive electrical stimulation of bone fractures |
US4889120A (en) * | 1984-11-13 | 1989-12-26 | Gordon Robert T | Method for the connection of biological structures |
US4616629A (en) * | 1985-05-24 | 1986-10-14 | Electro-Biology, Inc. | Coil construction for electromagnetic treatment of an afflicted body region |
US4672951A (en) * | 1985-12-30 | 1987-06-16 | Bio-Electric, Inc. | Method and apparatus for treatment of biological tissue |
US4865733A (en) * | 1986-03-22 | 1989-09-12 | Toa Nenryo Kogyo K.K. | Cell separator device |
US5000178A (en) * | 1986-05-23 | 1991-03-19 | Lti Biomedical, Inc. | Shielded electromagnetic transducer |
IL79788A (en) * | 1986-08-21 | 1992-07-15 | Zeev Kitov | Therapeutic electrostatic device |
US5100373A (en) * | 1989-01-09 | 1992-03-31 | Life Resonances, Inc. | Techniques for controlling osteoporosis using non-invasive magnetic fields |
US5067940A (en) * | 1988-03-23 | 1991-11-26 | Life Resonances, Inc. | Method and apparatus for controlling the growth of cartilage |
US5106361A (en) * | 1988-03-23 | 1992-04-21 | Life Resonances, Inc. | Method and apparatus for controlling the growth of non-osseous non-cartilaginous solid connective tissue |
US4932951A (en) * | 1988-03-23 | 1990-06-12 | Life Resonances, Inc. | Method and apparatus for controlling tissue growth and an applied fluctuating magnetic field |
US5215642A (en) * | 1986-10-27 | 1993-06-01 | Life Resonances, Inc. | Improved method and apparatus for regulating transmembrane ion movement |
US5087336A (en) * | 1989-01-09 | 1992-02-11 | Life Resonances, Inc. | Methods and apparatus for regulating transmembrane ion movement utilizing selective harmonic frequencies and simultaneous multiple ion regulation |
US5290409A (en) * | 1986-10-27 | 1994-03-01 | Life Resonances, Inc. | Methods and apparatus for regulating transmembrane ion movement utilizing selective harmonic frequencies and simultaneous multiple ion regulation |
US5160591A (en) * | 1986-10-27 | 1992-11-03 | Life Resonances, Inc. | Methods and apparatus for regulating transmembrane ion movement utilizing selective harmonic frequencies and simultaneous multiple ion regulation |
US4818697A (en) * | 1986-10-27 | 1989-04-04 | Life Resonances, Inc. | Techniques for enhancing the permeability of ions through membranes |
US5052997A (en) * | 1987-04-10 | 1991-10-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Diathermy coil |
US5269745A (en) * | 1988-03-23 | 1993-12-14 | Life Resonances, Inc. | Method and apparatus for controlling tissue growth with an applied fluctuating magnetic field |
US5123898A (en) * | 1988-03-23 | 1992-06-23 | Life Resonances, Inc. | Method and apparatus for controlling tissue growth with an applied fluctuating magnetic field |
US5267939A (en) * | 1989-01-09 | 1993-12-07 | Life Resonances, Inc. | Techniques for controlling osteoporosis using non-invasive magnetic fields |
US5099756A (en) * | 1989-06-01 | 1992-03-31 | Harry H. Leveen | Radio frequency thermotherapy |
CA2021506A1 (en) * | 1989-08-17 | 1991-02-18 | Abraham R. Liboff | Electromagnetic treatment therapy for stroke victims |
US5077934A (en) * | 1989-09-22 | 1992-01-07 | Life Resonances, Inc. | Method and apparatus for controlling plant growth |
US5103806A (en) * | 1990-07-31 | 1992-04-14 | The Research Foundation Of State University Of New York | Method for the promotion of growth, ingrowth and healing of bone tissue and the prevention of osteopenia by mechanical loading of the bone tissue |
US5195940A (en) * | 1991-06-20 | 1993-03-23 | Iatromed, Inc. | Method for increased production of growth factor in living tissue using an applied fluctuating magnetic field |
DE69228531T2 (en) * | 1992-02-20 | 1999-07-29 | Neomedics, Inc., Budd Lake, N.J. | Implantable bone growth stimulator |
US5565005A (en) * | 1992-02-20 | 1996-10-15 | Amei Technologies Inc. | Implantable growth tissue stimulator and method operation |
US5524624A (en) * | 1994-05-05 | 1996-06-11 | Amei Technologies Inc. | Apparatus and method for stimulating tissue growth with ultrasound |
WO1995031939A1 (en) | 1994-05-25 | 1995-11-30 | Jacobson Jerry I | Method and apparatus for ameliorating aging process |
US5752911A (en) | 1995-04-27 | 1998-05-19 | Canedo; Luis E. | Electromagnetic method of treatment of epilepsy and apparatus |
US5880661A (en) * | 1996-04-01 | 1999-03-09 | Emf Therapeutics, Inc. | Complex magnetic field generating device |
US7789841B2 (en) | 1997-02-06 | 2010-09-07 | Exogen, Inc. | Method and apparatus for connective tissue treatment |
US5904659A (en) | 1997-02-14 | 1999-05-18 | Exogen, Inc. | Ultrasonic treatment for wounds |
US5968527A (en) * | 1997-02-27 | 1999-10-19 | Catholic University Of America, The | Protection of living systems from the adverse effects of stress |
US6083149A (en) * | 1997-10-22 | 2000-07-04 | Emf Therapeutics, Inc. | Magnetic field device and method for inhibiting angiogenesis and retarding growth rates of tumors in mammals |
US6007476A (en) * | 1997-10-22 | 1999-12-28 | Emf Therapeutics, Inc. | Non-particle, non-photonic device and method for affecting angiogenesis |
US6458071B1 (en) | 1997-12-08 | 2002-10-01 | Jerry I. Jacobson | Method for electromagnetically restructuring water for organismic consumption |
CA2295134A1 (en) | 1998-01-15 | 1999-07-22 | Amethyst Technologies, Inc. | Improved pulsed electromagnetic energy treatment apparatus and method |
US6099459A (en) * | 1998-09-04 | 2000-08-08 | Jacobson; Jerry I. | Magnetic field generating device and method of generating and applying a magnetic field for treatment of specified conditions |
US6463323B1 (en) | 1998-11-12 | 2002-10-08 | Em Vascular, Inc. | Electrically mediated angiogenesis |
US6149577A (en) * | 1999-03-18 | 2000-11-21 | Emf Therapeutics, Inc. | Apparatus and method for creating a substantially contained, finite magnetic field useful for relieving the symptoms pain and discomfort associated with degenerative diseases and disorders in mammals |
MXPA01011974A (en) | 1999-05-21 | 2002-05-06 | Exogen Inc | Apparatus and method for ultrasonically and electromagnetically treating tissue. |
US6200259B1 (en) * | 1999-06-03 | 2001-03-13 | Keith L. March | Method of treating cardiovascular disease by angiogenesis |
JP2003526403A (en) | 1999-06-14 | 2003-09-09 | エクソジェン インコーポレイテッド | Method and kit for cavitation induced tissue treatment with low intensity ultrasound |
US6556872B2 (en) | 1999-08-24 | 2003-04-29 | Ev Vascular, Inc. | Therapeutic device and method for treating diseases of cardiac muscle |
US6560489B2 (en) | 1999-08-24 | 2003-05-06 | Em Vascular, Inc. | Therapeutic device and method for treating diseases of cardiac muscle |
US6358196B1 (en) * | 1999-12-29 | 2002-03-19 | Reiza Rayman | Magnetic retraction system for laparoscopic surgery and method of use thereof |
US6620117B1 (en) | 2000-01-20 | 2003-09-16 | Connextech, L.L.C. | Vibrational device for stimulating tissue and organs |
DE10055686A1 (en) * | 2000-11-03 | 2002-05-08 | Biotronik Mess & Therapieg | Device for influencing cell proliferation mechanisms in vessels of the human or animal body |
US7429248B1 (en) | 2001-08-09 | 2008-09-30 | Exogen, Inc. | Method and apparatus for controlling acoustic modes in tissue healing applications |
NL1019206C2 (en) | 2001-10-22 | 2003-04-23 | Johannes Josephus Maria Cuppen | Device and method for electromagnetic therapy. |
US6733435B2 (en) | 2002-03-08 | 2004-05-11 | Canedo Luis | Electromagnetic method of treatment of lesions associated with inadequate blood perfusion, partial denervation, tissue loss, pain, edema, inflammation and infection |
US6884227B2 (en) | 2002-11-08 | 2005-04-26 | Juvent, Inc. | Apparatuses and methods for therapeutically treating damaged tissues, bone fractures, osteopenia, or osteoporosis |
US7207954B2 (en) * | 2002-11-08 | 2007-04-24 | Juvent, Inc. | Apparatus and methods for therapeutically treating damaged tissues, bone fractures, osteopenia, or osteoporosis |
US7985191B2 (en) * | 2002-11-08 | 2011-07-26 | American Medical Innovations, L.L.C. | Apparatus and methods for therapeutically treating damaged tissues, bone fractures, osteopenia, or osteoporosis |
US20050059153A1 (en) * | 2003-01-22 | 2005-03-17 | George Frank R. | Electromagnetic activation of gene expression and cell growth |
US7186209B2 (en) | 2003-10-09 | 2007-03-06 | Jacobson Jerry I | Cardioelectromagnetic treatment |
US20060034943A1 (en) * | 2003-10-31 | 2006-02-16 | Technology Innovations Llc | Process for treating a biological organism |
US20130218235A9 (en) * | 2005-03-07 | 2013-08-22 | Arthur A. Pilla | Excessive fibrous capsule formation and capsular contracture apparatus and method for using same |
US8961385B2 (en) * | 2003-12-05 | 2015-02-24 | Ivivi Health Sciences, Llc | Devices and method for treatment of degenerative joint diseases with electromagnetic fields |
US9433797B2 (en) | 2003-12-05 | 2016-09-06 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurodegenerative conditions |
US9415233B2 (en) | 2003-12-05 | 2016-08-16 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurological pain |
US7744524B2 (en) * | 2003-12-05 | 2010-06-29 | Ivivi Health Sciences, Llc | Apparatus and method for electromagnetic treatment of plant, animal, and human tissue, organs, cells, and molecules |
US9440089B2 (en) | 2003-12-05 | 2016-09-13 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurological injury or condition caused by a stroke |
US9427598B2 (en) | 2010-10-01 | 2016-08-30 | Rio Grande Neurosciences, Inc. | Method and apparatus for electromagnetic treatment of head, cerebral and neural injury in animals and humans |
US9656096B2 (en) | 2003-12-05 | 2017-05-23 | Rio Grande Neurosciences, Inc. | Method and apparatus for electromagnetic enhancement of biochemical signaling pathways for therapeutics and prophylaxis in plants, animals and humans |
US20110112352A1 (en) * | 2003-12-05 | 2011-05-12 | Pilla Arthur A | Apparatus and method for electromagnetic treatment |
US10350428B2 (en) | 2014-11-04 | 2019-07-16 | Endonovo Therapetics, Inc. | Method and apparatus for electromagnetic treatment of living systems |
KR20070024533A (en) | 2004-04-19 | 2007-03-02 | 아이비비 테크놀로지스, 아이엔씨. | Electromagnetic Therapy Device and Method |
US8043290B2 (en) * | 2004-09-29 | 2011-10-25 | The Regents Of The University Of California, San Francisco | Apparatus and methods for magnetic alteration of deformities |
US8142454B2 (en) * | 2004-09-29 | 2012-03-27 | The Regents Of The University Of California, San Francisco | Apparatus and method for magnetic alteration of anatomical features |
US8439915B2 (en) * | 2004-09-29 | 2013-05-14 | The Regents Of The University Of California | Apparatus and methods for magnetic alteration of anatomical features |
US20060271107A1 (en) * | 2004-09-29 | 2006-11-30 | Harrison Michael R | Apparatus and methods for magnetic alteration of anatomical features |
US20060079897A1 (en) * | 2004-09-29 | 2006-04-13 | Harrison Michael R | Apparatus and methods for magnetic alteration of anatomical features |
DE102005007851A1 (en) * | 2005-02-21 | 2006-08-24 | Siemens Ag | Irradiation apparatus for irradiating a living organism with electromagnetic radiation to affect the biologic structure of the organism |
US20070021693A1 (en) * | 2005-03-07 | 2007-01-25 | Titi Trandafir | Dynamic motion therapy apparatus having a treatment feedback indicator |
US8603017B2 (en) * | 2005-03-07 | 2013-12-10 | American Medical Innovations, L.L.C. | Vibrational therapy assembly for treating and preventing the onset of deep venous thrombosis |
US20070055185A1 (en) * | 2005-03-07 | 2007-03-08 | Juvent Inc. | Dynamic motion therapy apparatus having a treatment feedback indicator |
US20070043310A1 (en) * | 2005-03-07 | 2007-02-22 | Juvent Inc. | Method and apparatus for monitoring patient compliance during dynamic motion therapy |
AU2006226886B2 (en) * | 2005-03-24 | 2010-11-25 | American Medical Innovations L.L.C. | Apparatus and method for monitoring and controlling the transmissibility of mechanical vibration energy during dynamic motion therapy |
JP4821957B2 (en) * | 2005-05-09 | 2011-11-24 | 株式会社P・マインド | High frequency treatment device |
US20080139979A1 (en) * | 2005-07-18 | 2008-06-12 | Juvent, Inc. | Vibrational therapy assembly adapted for removably mounting to a bed |
US20070055096A1 (en) * | 2005-07-29 | 2007-03-08 | Berry Cheryl J | Sexual stimulation devices and toys with features for playing audio and/or video received from an external source |
WO2007103414A2 (en) * | 2006-03-09 | 2007-09-13 | Juvent, Inc. | Mechanical loading apparatus having a signal modulating assembly |
US20080009776A1 (en) * | 2006-03-24 | 2008-01-10 | Juvent Inc. | Apparatus and method for monitoring and controlling the transmissibility of mechanical vibration energy during dynamic motion therapy |
US8672826B2 (en) * | 2006-04-07 | 2014-03-18 | Global Energy Medicine Pty. Ltd. | Vivo stimulation of cellular material |
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Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US435343A (en) * | 1890-08-26 | Articulated electro-magnet | ||
US717072A (en) * | 1901-05-08 | 1902-12-30 | John Burry | Magnetotherapeutic apparatus. |
US743373A (en) * | 1903-10-02 | 1903-11-03 | Emile Bachelet | Electromagnetic therapeutic apparatus. |
US2368207A (en) * | 1941-01-30 | 1945-01-30 | Warren S Eaton | Method of and means for therapeutic treatment |
US2404283A (en) * | 1942-01-17 | 1946-07-16 | Licbel Flarsheim Company | Electrode for diathermy treatments |
JPH028485U (en) * | 1988-06-29 | 1990-01-19 |
-
1972
- 1972-04-05 CH CH498172A patent/CH539438A/en not_active IP Right Cessation
- 1972-04-05 AT AT291872A patent/AT316729B/en not_active IP Right Cessation
- 1972-04-05 AT AT291772A patent/AT336174B/en not_active IP Right Cessation
- 1972-04-05 CH CH498072A patent/CH551201A/en not_active IP Right Cessation
- 1972-04-06 GB GB1601472A patent/GB1393701A/en not_active Expired
- 1972-04-06 SE SE7204461A patent/SE387240B/en unknown
- 1972-04-06 US US00241728A patent/US3820534A/en not_active Expired - Lifetime
- 1972-04-06 JP JP47034796A patent/JPS5839547B1/ja active Pending
- 1972-04-06 US US241727A patent/US3890953A/en not_active Expired - Lifetime
- 1972-04-06 SE SE7204462A patent/SE381813B/en unknown
- 1972-04-06 GB GB1601572A patent/GB1393702A/en not_active Expired
-
1976
- 1976-07-21 SE SE7608327A patent/SE412991B/en not_active IP Right Cessation
-
1977
- 1977-03-07 JP JP2533177A patent/JPS52142887A/en active Granted
-
1981
- 1981-02-03 JP JP1559281A patent/JPS56125061A/en active Granted
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US3964473A (en) * | 1972-09-21 | 1976-06-22 | Telectronics Pty. Limited | Bone prosthesis |
US4195367A (en) * | 1976-03-19 | 1980-04-01 | Werner Kraus | Long-term endoprosthesis |
US4214322A (en) * | 1976-03-19 | 1980-07-29 | Werner Kraus | Long-term endoprosthesis |
US4216548A (en) * | 1976-03-19 | 1980-08-12 | Werner Kraus | Long-term endoprosthesis |
US4306564A (en) * | 1977-09-22 | 1981-12-22 | Werner Kraus | Electrification attachment for an osteo-synthesis implantate |
US4421115A (en) * | 1977-09-22 | 1983-12-20 | Werner Kraus | Electrification attachment for an osteosynthesis implantate |
US4549547A (en) * | 1982-07-27 | 1985-10-29 | Trustees Of The University Of Pennsylvania | Implantable bone growth stimulator |
US4611597A (en) * | 1982-11-03 | 1986-09-16 | Werner Kraus | Implantable device for the stimulation of bone growth |
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US7455672B2 (en) | 1994-05-27 | 2008-11-25 | Gary Karlin Michelson | Method for the delivery of electrical current to promote bone growth between adjacent bone masses |
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US20040024400A1 (en) * | 1994-05-27 | 2004-02-05 | Michelson Gary Karlin | Method for the delivery of electrical current to promote bone growth between adjacent bone masses |
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US6143035A (en) * | 1999-01-28 | 2000-11-07 | Depuy Orthopaedics, Inc. | Implanted bone stimulator and prosthesis system and method of enhancing bone growth |
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US7101374B2 (en) | 2000-06-13 | 2006-09-05 | Hyde Jr Edward R | Magnetic array implant |
US6387096B1 (en) * | 2000-06-13 | 2002-05-14 | Edward R. Hyde, Jr. | Magnetic array implant and method of treating adjacent bone portions |
US20030195633A1 (en) * | 2001-05-04 | 2003-10-16 | Hyde Edward R. | Magnetic array implant and prosthesis insert |
US20030187510A1 (en) * | 2001-05-04 | 2003-10-02 | Hyde Edward R. | Mobile bearing prostheses |
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US20070173681A1 (en) * | 2003-11-11 | 2007-07-26 | Roberto Giardino | Electromagnetic field stimulator device for anatomic biophysical chondroprotection |
US7566295B2 (en) | 2003-11-11 | 2009-07-28 | Igea S.R.L. | Electromagnetic field stimulator device for anatomic biophysical chondroprotection |
USRE46582E1 (en) | 2004-06-07 | 2017-10-24 | DePuy Synthes Products, Inc. | Orthopaedic implant with sensors |
US8083741B2 (en) | 2004-06-07 | 2011-12-27 | Synthes Usa, Llc | Orthopaedic implant with sensors |
US20060052782A1 (en) * | 2004-06-07 | 2006-03-09 | Chad Morgan | Orthopaedic implant with sensors |
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US20120165950A1 (en) * | 2010-12-23 | 2012-06-28 | Rainer Baumgart | Implantable prosthesis for replacing a human hip or knee joint and the adjoining bone sections |
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US10004916B2 (en) | 2011-12-27 | 2018-06-26 | Richard A. Rogachefsky | Orthopedic fixation device with magnetic field generator |
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US8679189B1 (en) * | 2013-02-11 | 2014-03-25 | Amendia Inc. | Bone growth enhancing implant |
US10838406B2 (en) | 2013-02-11 | 2020-11-17 | The Aerospace Corporation | Systems and methods for the patterning of material substrates |
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Also Published As
Publication number | Publication date |
---|---|
SE412991B (en) | 1980-03-31 |
CH539438A (en) | 1973-07-31 |
GB1393701A (en) | 1975-05-14 |
JPS6141583B2 (en) | 1986-09-16 |
AT316729B (en) | 1974-07-25 |
JPS52142887A (en) | 1977-11-29 |
GB1393702A (en) | 1975-05-14 |
ATA291772A (en) | 1976-08-15 |
CH551201A (en) | 1974-07-15 |
SE381813B (en) | 1975-12-22 |
JPS56125061A (en) | 1981-10-01 |
SE387240B (en) | 1976-09-06 |
SE7608327L (en) | 1976-07-21 |
AT336174B (en) | 1977-04-25 |
JPS5839547B1 (en) | 1983-08-30 |
JPS5311799B2 (en) | 1978-04-24 |
US3890953A (en) | 1975-06-24 |
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