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US3807400A - Inhaling device for medicinal powder compositions - Google Patents

Inhaling device for medicinal powder compositions Download PDF

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Publication number
US3807400A
US3807400A US00266243A US26624372A US3807400A US 3807400 A US3807400 A US 3807400A US 00266243 A US00266243 A US 00266243A US 26624372 A US26624372 A US 26624372A US 3807400 A US3807400 A US 3807400A
Authority
US
United States
Prior art keywords
capsule
piercing
medicinal powder
inhaling device
platform
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00266243A
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English (en)
Inventor
S Cocozza
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ISF SpA
Original Assignee
ISF SpA
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Filing date
Publication date
Application filed by ISF SpA filed Critical ISF SpA
Application granted granted Critical
Publication of US3807400A publication Critical patent/US3807400A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • an inhaling device for medicinal powder compositions provided in capsule form comprising, in combination, a disc-shaped lower member provided with a cavity in which the said capsule is to be located, which cavity is formed in an upwardly extending platform of said member, and at least one piercing member for said capsule, which piercing member is resiliently biased away from said capsule and projects from said platform, an upper member formed with a number of tangential passages, said upper member providing a lower edge to provide a cam which is able to reciprocate said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with a telescopically extendable mouthpiece, whirling chamher being defined in the region of the extended mouthpiece.
  • FIG. 1 is a side view of an inhaling device in accordance with the invention in its inactive or retracted position;
  • FIG. 2 is a side view of an inhaling device in accordance with the invention in it active or operative position;
  • FIG. 3 is a top plan view of the inhaling device shown in FIGS. 1 and 2;
  • FIG. 4 is a radial partial sectional view of the inhaling device of the invention.
  • FIGS. 5 and 6, on the same scale as FIG. 1, are respectively the bottom view and the top view of the upper and lower component forming the upper member of the inhaling device in accordance with the invenber 31 which is formed with an upwardly extending platform, wherein a cavity 40 is provided for receiving a capsule 45 filled with a suitable medicinal powder composition.
  • the lower member 31 also contains the piercing device which is housed in the said platform as will be explained in more detail hereinafter.
  • the central top portion of the upper member 1 has supported therein a plurality of telescopically movable integral sleeve members, which upon being extended outwardly, form the mixing chamber W.
  • the component 2 is formed with trapezoidally profiled ribs 4 which define therebetween tangential passages 61 (see FIG. 6), and the component 1 (see FIG.
  • Component 1 which extend in the assembled position into the said tangential passages or gaps 61.
  • Component 1 is provided with a set of pins 3 (see FIGS. 4 and 5 which c0- operate with, and on the same transverse side of, the gaps formed by the tangential passage 61, whereby the two components 1 and 2 are precisely positioned with one another in the assembled position. Secure connection of the two components 1 and 2 is effected by the provision of suitable adhesive means at 29.
  • the mouthpiece of the inhaling device of the invention is telescopically extendable by means of sleeve members 12, 13 and 14.
  • the member 12 is formed with outlet openings 52 for the powder to be inhaled.
  • a net of plastics material is adhesively connected to the lower end of the mouthpiece 12 and operates as'a screen 53, preventing the capsule debris passing to the mouthpiece l2.
  • the component 2 is formed with a peripheral downwardly projecting skirt the inside surface of which is provided with inwardly extending profiled projections 50 which act as cams with profiled recesses 69 for actuating the piercing device P, both represented in dotted lines inFIG. 7.
  • the piercing device will be hereinafter illustrated with reference to FIGS. 4 and 7.
  • a piercing needle 8 for the capsule is'housed in a radial recess 40 of the plat-' form of the lower member 31 and is urged away from the capsule by means of a spring 9.
  • the needle terminates with a push-button 10 which co-operates with the cams 50 and recesses 69, and the said push-button 10 may be held in its maximum radially extending position by a ring 51 which is frictionally mounted around the platform of the lower member 31.
  • a plurality of knurled portions 57 may be provided in the lower member 31 of the inhaling device 30 to facilitate grasping of the device by a user.
  • two diametrally opposed piercing devices P are provided.
  • the capsule After having separated the lower member 31 from the upper member (comprising components 1 and 2) the capsule is placed in the cavity 40 provided in the upwardly extending platform of the lower member 31 thereafter the lower member 31 is frictionally secured to the upper member, by the reaction of the said springs 9 against the said skirt.
  • the cams and recesses 69 Upon relative rotational movement between the upper and lower members, the cams and recesses 69 cause a number of reciprocations of the needle 8 and, therefore a number of piercing operations of the capsule in diametrally opposed positions is effected.
  • the patient with the mouthpiece already telescopically extended causes, by aspiration, a displacement and movement of the capsule into the extended mixing or whirling chamber and, therefore, the medicinal powder composition is dispersed into the said chamber and is finally inhaled into the patients mouth. It can be seen that the powder composition traverses, prior to inhalation by the patient, the filter screen 53 and the openings 52 moulded in the central telescopic member 12.
  • An inhaling device for medicinal powder compositions provided in capsule form comprising, in combination: a disc shaped lower platform member provided with a cavity in which the said capsule is to be located, and at least one piercing member for said capsule projecting from the said platform, a spring for biasing the piercing member from said capsule and projecting it from said platform, an upper member, formed with a number of tangential passages extending from the outside to the interior thereof said upper member having a recess providing a peripheral cam shaped wall portion for actuating said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with an outwardly telescopically extendable sleeve means, including a mouth engaging portion, which when extended defines a whirling chamber for said capsule and its medicinal powder contents.
  • the upper member comprises an upper and a lower component, connected together by adhesive means and together defining the tangential passages, the upper component including a plurality of pins uniformly and radially spaced in like manner as the tangential passages and of the same size thereof, whereupon, in the assembled position, the pins co-operate with the tangential passages so that the mutual disposition of both components is exactly located before adhesively securing the two components together.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
US00266243A 1971-07-17 1972-06-26 Inhaling device for medicinal powder compositions Expired - Lifetime US3807400A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT26971/71A IT941426B (it) 1971-07-17 1971-07-17 Inalatore a camera di turbinio per sostanze medicamentose polveriformi

Publications (1)

Publication Number Publication Date
US3807400A true US3807400A (en) 1974-04-30

Family

ID=11220655

Family Applications (1)

Application Number Title Priority Date Filing Date
US00266243A Expired - Lifetime US3807400A (en) 1971-07-17 1972-06-26 Inhaling device for medicinal powder compositions

Country Status (10)

Country Link
US (1) US3807400A (xx)
AT (1) AT333415B (xx)
BE (1) BE781102A (xx)
CA (1) CA999202A (xx)
CH (1) CH563167A5 (xx)
ES (1) ES208808Y (xx)
FR (1) FR2146202B1 (xx)
GB (1) GB1331216A (xx)
IT (1) IT941426B (xx)
NL (1) NL7305363A (xx)

Cited By (98)

* Cited by examiner, † Cited by third party
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US3858583A (en) * 1973-02-26 1975-01-07 Allen & Hanburys Ltd Medicament inhalation device
US3870046A (en) * 1973-05-08 1975-03-11 Miles Lab Insufflator
US3938516A (en) * 1975-01-13 1976-02-17 Syntex Puerto Rico, Inc. Inhalation device
US3948264A (en) * 1975-05-21 1976-04-06 Mead Johnson & Company Inhalation device
US3964483A (en) * 1975-01-13 1976-06-22 Syntex Puerto Rico, Inc. Inhalation device
US3973566A (en) * 1975-01-13 1976-08-10 Syntex Puerto Rico Inc. Inhalation device
US3991761A (en) * 1974-03-18 1976-11-16 Salvatore Cocozza Inhaler for powdered medicaments
US4014336A (en) * 1975-01-13 1977-03-29 Syntex Puerto Rico, Inc. Inhalation device
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
US4095596A (en) * 1976-11-26 1978-06-20 Smithkline Corporation Nasal inhaler
US4155359A (en) * 1977-05-23 1979-05-22 Antoni Zagorski Air filtering mask
US4249526A (en) * 1978-05-03 1981-02-10 Fisons Limited Inhalation device
EP0041783A1 (en) * 1980-06-06 1981-12-16 FISONS plc Inhalation device for powdered medicaments
DK154399B (da) * 1976-02-10 1988-11-14 Allen & Hanburys Ltd Inhalationsapparat
US4884565A (en) * 1987-08-17 1989-12-05 Miat S.P.A. Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5207217A (en) * 1990-07-16 1993-05-04 Promo Pack Sa Multiple single-dose inhaler for medicaments in powder form
US5331953A (en) * 1989-03-07 1994-07-26 Aktiebolaget Draco Device in connection with an inhaler
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
US5460173A (en) * 1993-03-03 1995-10-24 Tenax Corporation Dry powder inhaler medicament carrier
US5522383A (en) * 1990-06-14 1996-06-04 Rhone-Poulenc Rorer Ltd. Powder inhaler having capsule holding structure and anti-static walls
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
US5676130A (en) * 1992-03-19 1997-10-14 Boehringer Ingelheim Gmbh, Inc. Separator for powdered inhalers
US5692496A (en) * 1995-08-02 1997-12-02 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5823183A (en) * 1995-08-02 1998-10-20 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5988163A (en) * 1995-08-02 1999-11-23 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament
WO1999064095A2 (en) 1998-06-12 1999-12-16 Microdose Technologies, Inc. Metering, packaging and delivery of pharmaceuticals and drugs
US6048857A (en) * 1989-10-17 2000-04-11 Ellinwood, Jr.; Everett H. Dosing method of administering medicaments via inhalation administration
US6142146A (en) * 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device
US6152130A (en) * 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
US6209538B1 (en) * 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6237591B1 (en) 1998-11-02 2001-05-29 Dura Pharmaceuticals, Inc. Turbine dry powder inhaler
WO2001062342A1 (en) * 2000-02-24 2001-08-30 Irm Technologies Pty Ltd Nasal filter and sampler
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US20020134382A1 (en) * 2000-05-10 2002-09-26 Snow John M. Medicament container with same side airflow inlet and outlet and method of use
US20030047184A1 (en) * 2001-01-12 2003-03-13 Lockhart Artis R. Medicament respiratory delivery device
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
US20040149283A1 (en) * 2002-12-12 2004-08-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient
US20040163645A1 (en) * 2001-01-12 2004-08-26 Connelly Robert I. Medicament inhalation delivery devices and methods for using the same
US6792945B2 (en) * 1990-03-02 2004-09-21 Glaxo Group Limited Inhalation device
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US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
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US20080163610A1 (en) * 2007-01-05 2008-07-10 Matthew Thomas Baird Method and system for regenerating exhaust system filtering and catalyst components using variable high engine idle
US20080295832A1 (en) * 2005-10-28 2008-12-04 Johannes Geser Inhaler with Mouthpiece Having a Microbiological Protective Function
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Cited By (181)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3858583A (en) * 1973-02-26 1975-01-07 Allen & Hanburys Ltd Medicament inhalation device
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
US3870046A (en) * 1973-05-08 1975-03-11 Miles Lab Insufflator
US3991761A (en) * 1974-03-18 1976-11-16 Salvatore Cocozza Inhaler for powdered medicaments
US3938516A (en) * 1975-01-13 1976-02-17 Syntex Puerto Rico, Inc. Inhalation device
US3964483A (en) * 1975-01-13 1976-06-22 Syntex Puerto Rico, Inc. Inhalation device
US3973566A (en) * 1975-01-13 1976-08-10 Syntex Puerto Rico Inc. Inhalation device
US4014336A (en) * 1975-01-13 1977-03-29 Syntex Puerto Rico, Inc. Inhalation device
US3948264A (en) * 1975-05-21 1976-04-06 Mead Johnson & Company Inhalation device
DK154399B (da) * 1976-02-10 1988-11-14 Allen & Hanburys Ltd Inhalationsapparat
US4095596A (en) * 1976-11-26 1978-06-20 Smithkline Corporation Nasal inhaler
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BE781102A (fr) 1972-07-17
FR2146202B1 (xx) 1976-01-16
ES208808Y (es) 1976-07-16
NL7305363A (xx) 1974-05-07
GB1331216A (en) 1973-09-26
CA999202A (fr) 1976-11-02
AT333415B (de) 1976-11-25
ATA346473A (de) 1976-03-15
FR2146202A1 (xx) 1973-03-02
ES208808U (es) 1976-04-01
IT941426B (it) 1973-03-01

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