[go: up one dir, main page]

US3790582A - Certain pyridylphosphates,thiophosphates,phosphonates and thiophosphonates - Google Patents

Certain pyridylphosphates,thiophosphates,phosphonates and thiophosphonates Download PDF

Info

Publication number
US3790582A
US3790582A US00157636A US3790582DA US3790582A US 3790582 A US3790582 A US 3790582A US 00157636 A US00157636 A US 00157636A US 3790582D A US3790582D A US 3790582DA US 3790582 A US3790582 A US 3790582A
Authority
US
United States
Prior art keywords
methyl
percent
pyridine
solution
sodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00157636A
Inventor
D Demozay
D Pillon
J Ducret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pepro SA
Original Assignee
Pepro SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pepro SA filed Critical Pepro SA
Application granted granted Critical
Publication of US3790582A publication Critical patent/US3790582A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Definitions

  • R is an alkyl, alkoxy, containing from 1 to 4 carbon atoms, halogenoalkyl, alkylamino, dialkylamino, phenyl, phenoxy radical in which the alkyl group contains 1 to 4 carbon atoms;
  • R is an alkyl radical containing from 1 to 4 carbon atoms, which maye be halogenated;
  • R and R are identical or different, and selected from hydrogen, halogen, nitro, or cyano, but in which both cannot be hydrogen; and
  • X is oxygen or sulfur.
  • Phosphorus derivatives containing one pyridinic radical in their molecule are already known, and some of them have been reported as having advantageous insecticide properties, namely those described in French Pat. No. 1,063,067 dated Apr. 19, 1962.
  • the compounds of this invention are prepared by allowing a chloride of phosphoric, phosphonic, thiophosphoric, or phosphoramidic acid to react with a substituted hydroxy 3 methyl 6 pyridine, in the United States Patent presence of a hydracid acceptor, or with one of the salts of the hydroxypyridine.
  • the reaction is preferably carried out in the presence of organic solvents, such as ketones, alcohols, aromatic or aliphatic hydrocarbons.
  • a reaction temperature is selected within the range of 20 C. to C.
  • the solution is neutralized with'0.2 M of soda, and the pyridine is removed by steam distillation. Precipitates form in the remaining solution upon cooling. The precipitate is washed and dried. It is black, and its melting point is not well defined. It is dissolved in ml. of ethanol, and treated with bone black. After filtering and cooling the solution, a light beige precipitate is obtained.
  • the resulting precipitate is filtered. It is then dissolved in 2 l. of soda solution containing 25 g./l., and treated at boiling with bone black for 15 minutes. After filtering, the solution is cooled, and then neutralized with 80 ml. of acetic acid.
  • the light beige precipitate thus obtained is filtered and dried.
  • the sodium chloride is filtered OE and the alcohol is removed.
  • the residue is taken up with 100' ml. of chloroform, and washed once with m1. of 5% sodium bicarbonate, and twice with 80 m1. of distilled water, and then dried with magnesium sulfate.
  • the chloroform is removed under water pump vacuum, and then under high vacuum during one hour. The oil thus obtained is of light brown color.
  • EXAIVIPLE 7 O-methyl and 0-3 (nitro-2-methyl-6)pyridyl methylphosphate CHzO CH3 N/
  • the sodium ethoxide prepared from 1.15 g. (0.05 M) of sodium and 40 ml. of absolute alcohol is added to 7.7 g. of nitro-2-hydroxy-3-methyl-6-pyridine (0.05 M) in solution in 40 ml. of absolute alcohol. The reaction is continued for one hour at room temperature. 6.4 g. (0.05 M) of O-methy1-methylchlorophosphinate are then added at ordinary temperature, after which the mixture is refluxed for one hour.
  • the sodium chloride is then filtered off, and the alcohol removed.
  • the residue is taken up with ml. of chloroform, and washed once with 80 ml. of 5% sodium bicarbonate and twice with 80 ml. of distilled water, and then dried over magnesium sulfate.
  • the chloroform is then removed, and a raw light yellow oil is obtained.
  • the sodium ethoxide prepared from 0.9 g. (0.04 M) of sodium and 40 ml. of absolute alcohol, is added to 5.75 g. of chloro-2-hydroxy-3-methyl-6-pyridine (0.04
  • the sodium chloride is filtered otf and the alcohol removed.
  • the residue is taken up with 100 ml. of chloroform and washed with 80 ml. of 5% sodium bicarbonate, and then twice with 80 ml. of distilled water. It is then dried over magnesium sulfate.
  • the chloroform is then removed and the oil is distilled under high vacuum.
  • the resulting oil (yield, 63.5%; Weight, 7.5 g.) has a very pale yellow color and the following physical constants:
  • Boiling point 0.006 mm. Hg C-.. 112 20 1.5235
  • EXAMPLE 9 O-ethyl and -3 (chloro-2-methyl-6)pyridyl dimethylamidophosphate CzHsO
  • the sodium ethoxide prepared from 0.9 g. (0.04 M) of sodium and 40 ml. of absolute alcohol is added to 5.75 g. (0.04 M) of chloro-2-hydroxy-3-methyl-6-pyridine in solution in 40 ml. of absolute alcohol.
  • the reaction is carried on for one hour at room temperature. 6.85 g. of ethyl-dimethylamido-chlorophosphate (0.04 M) are then added at room temperature, and the reaction mixture is then refluxed for one hour.
  • the sodium chloride is filtered, and the alcohol removed.
  • the residue is taken up with 100 ml. of chloroform, and then washed once with 80 ml. of sodium bicarbonate and once with 80 ml. of distilled water. It is then dried over magnesium sulfate.
  • the chloroform is then removed, and the oil is distilled under high vacuum. The resulting oil is colorless.
  • EXAMPLE 10 O-ethyland O-3 (ch1oro-2-methyl-6)pyridyl phenylthiophosphonate
  • the sodium ethoxide prepared from 0.8 g. (0.035 M) of sodium and 40 ml. of absolute alcohol is added to 5 g. (0.035 M) of chloro-2-hydroxy-3-methyl-6-pyridine in solution in 40 ml. of absolute alcohol.
  • the reaction is maintained for one hour at ordinary room temperature. 7.7 g. (0.035 M) of ethyl-phenylchlorothiophosphonate are then added at ordinary temperature, and the reaction mixture is refluxed for one hour.
  • the sodium chloride is filtered, and the alcohol removed.
  • the residue is taken up with 100 ml. of chloroform, and washed once with 80 ml. of 5% sodium bicarbonate solution, and then with 80 ml. of distilled water. It is then dried over magnesium sulfate.
  • EXAMPLE l1 O-O-diethyl and O-3 (bromo-2-methyl-6)pyridyl phosphate CgHsO B 1' CH3
  • the sodium ethoxide prepared from 0.8 g. (0.035 M) of sodium and 40 ml. of absolute alcohol is added to 6.6 g. (0.035 M) of bromo 2-hydroxy-3-methyl-6-pyridine in soltuion in 40 ml. of absolute alcohol.
  • the reaction is carried on for one hour at room temperature. 6.05 g. of diethylchlorophosphate 0.035 M) are then added at ordinary temperature, and the mixture is refluxed for one hour.
  • the sodium chloride is filtered, and the alcohol removed.
  • the residue is taken up with 100 ml. of chloroform, and then washed with ml. of 5% sodium bicarbonate, after which it is washed again with 80 ml. of distilled water and dried over magnesium sulfate.
  • the chloroform is removed, and the resulting oil is kept raw.
  • EXAMPLE 12 O-O-diethyl and O-3 (chloro-2-nitro-4-methyl-6)pyridyl phosphate N/ CH3
  • the sodium ethoxide prepared from 0.8 g. (0.035 M) of sodium and 40 ml. of absolute alcohol is added to 6.6 g. (0.035 M) of chloro 2-hydroxy-3-nitro-4-methyl-6-pyridine in solution in 40 ml. of absolute alcohol.
  • the reaction is carried on for one hour'at ordinary temperature. 6.05 g. (0.035 M) of diethylchlorophosphate are then added at room temperature, and the mixture is then refluxed for one hour.
  • the sodium chloride is filtered, and the alcohol removed, as by distillation. The residue is then taken up with ml. of chloroform, and washed with 80 ml. of 5% sodium bicarbonate, after which it is washed again with 80 ml. of distilled water and dried over magnesium sulfate.
  • EXAMPLE 14 Test on Ephestia kuhnielle A few drops (3) of an acetone solution of the active material to be tested are deposited onto an azyme cachet. The acetone is then allowed to evaporate, and eggs of Ephestia kuhnielle are disposed on said cachet, and covered with a glass plate to prevent any escape. A mortality check is efiected 10 days later.
  • products Nos. 9 and 40 give 100% mortality at a concentration of 0.0005 g./l.
  • Products Nos. 3, 11, 12, 21 and 26 give 100% mortality at a concentration of 0.001 g./l.
  • known Compounds A and C require a concentration of 0.01 g./l. for obtaining an 80% mortality
  • Compounds B and C require a concentration of 0.1 g./1. for obtaining 100% mortality
  • DDT and a-naphthyl N-methylcarbamate (carbaryl) require a concentration of 0.1 g./l. in order to obtain a similar result.
  • EXAMPLE 15 Test on Tetranychus urticae Bean plants infested with Tetranychus urticae are treated directly by means of a compressed air sprayer filled with a solution of the active material to be tested. The mortality check is made by comparison with a reference series of untreated bean plants.
  • Compounds Nos. 3, 5, 8, 10, 15, 21, 22 and 42 give 100% mortality among the cockroaches at a concentration of 0.1 g./l.
  • known Compounds A and B require a concentration of l g./I. to obtain the same result.
  • insecticides such as azinphosethyl [0,0 diethyl S-(4, oxo l, 2, 3 benzotriazin-3 ⁇ 4 H]y1 methyl)phosphorodithicate], malathion [S 1, 2 di(ethoxycarbonyl)ethyl dimethylphosphorothiolothionate], or ronnel [0,0 dimethyl O-(2,3,4-trich1orophenyl) phosphorothioate] should be used at concentrations of the order of one gram/liter to bring about a complete destruction of cockroaches.
  • a check for the mortality rate is effected by means of a binocular magnifying glass.
  • the compounds of this invention should seldom be used in the pure state, except for very low volume applications (U.L.V. treatments).
  • these active materials are mixed with various ad juvants and carriers, or liquid and/or solid diluents, so as to obtain formulations suitable for the utilization requirements and the character of the problem to be solved.
  • Such formulations may be employed in the form of granules, powdering powders, wettable powders or solutions adapted to be emulsified.
  • the preparation of such formulations pertains to well-known techniques, which are, in particular, described in published works such as Chemistry of the Pesticides, by D. E. H. Frear, 3rd ed., pp. 409'-
  • the polyvalent action of the compounds of this invention enables them to be used in fighting against the parasites of various crops in the agicultural, arboricultural and viticultural fields, as well as in the household or public health fields.
  • a compound having the formula ⁇ P---O R20/ R wherein R is selected from the group consisting of C to C alkyl, C to C haloalkyl, C to 0., alkoxy, phenyl and phenoxy; R is C to C alkyl or C to C haloalkyl; R is halogen, R is hydrogen and X is S or O.
  • N ALAN L. ROTMAN, Primary Examiner 8 A compound as defined in claim 3 wherein the com- I U 8 C1 X R pound has the formula 71-94; 260-496 R, 297 P; 424-263 @i /P-O I 2 5-0 01

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

PHOSPHORIC DERIVATIVES CONTAINING SUBSTITUTED METHYLPYRIDINES AND HAVING THE GENERAL FORMULA

2-(CH3-),4-R4,5-(R2-O-P(=X)(-R1)-O-),6-R3-PYRIDINE

AND THEIR USE IN INSECTICIDAL, ACARICIDAL AND NEMATICIDAL COMPOSITIONS.

Description

3,790,582 CERTAIN PYRIDYLPHOSPHATES, THIOPHOS- PHATES, PHOSPHONATES AND THIOPHOS- PHONATES Daniel Demozay, Villeurbanne, and Daniel Pillon and Jacques Ducret, Lyon, France, assignors to Pepro, Societe pour le Developpemeut et la Vente de Specialites Chimiques, Lyon, France No Drawing. Filed June 28, 1971, Ser. No. 157,636
Claims priority, application France, June 30, 1970, 7024078 Int. Cl. C07d 31/50 US. Cl. 260-294.8 K 9 Claims ABSTRACT OF THE DISCLOSURE Phosphoric derivatives containing substituted methylpyridines and having the general formula R4 R1 X R3 N/ CH:
and their use in insecticidal, acaricidal and nematicidal compositions.
R CH:
wherein R is an alkyl, alkoxy, containing from 1 to 4 carbon atoms, halogenoalkyl, alkylamino, dialkylamino, phenyl, phenoxy radical in which the alkyl group contains 1 to 4 carbon atoms; R is an alkyl radical containing from 1 to 4 carbon atoms, which maye be halogenated; R and R are identical or different, and selected from hydrogen, halogen, nitro, or cyano, but in which both cannot be hydrogen; and X is oxygen or sulfur.
Phosphorus derivatives containing one pyridinic radical in their molecule are already known, and some of them have been reported as having advantageous insecticide properties, namely those described in French Pat. No. 1,063,067 dated Apr. 19, 1962.
We have discovered a series of new compounds wherein the phosphorous-containing radical is attached in the 3 position to the pyridinic ring, while having a methyl radical in the 6 position and may, besides, have substituents in the 2-4 position of said pyridinic nucleus. Said compounds have insecticidal and acaricidal properties much more advantageous than the derivatives described in the above-mentioned patent.
In general, the compounds of this invention are prepared by allowing a chloride of phosphoric, phosphonic, thiophosphoric, or phosphoramidic acid to react with a substituted hydroxy 3 methyl 6 pyridine, in the United States Patent presence of a hydracid acceptor, or with one of the salts of the hydroxypyridine. The reaction is preferably carried out in the presence of organic solvents, such as ketones, alcohols, aromatic or aliphatic hydrocarbons. In general, a reaction temperature is selected within the range of 20 C. to C.
The following examples, which are given by way of illustration, but not by way of limitation, show the method for preparing substituted hydroxypyridines (Examples l 5) on the one hand, and the preparation of the phosphoric esters (Examples 6-12) on the other hand.
EXAMPLE I Chloro-2-hydroxy-3-methyl-6-pyrid,ine
water until the 01- ions are eliminated, and then dried.
Weight obtained g 125 Melting point C-.." 198 Yield perce Said precipitate recrystallized in ethanol melts at 199 C.
Analysis.Calculated for C H CINO (percent): C, 50.17; H, 4.18; N, 9.75; Cl, 24.74. Found (percent): C, 50.22; H, 4.06; N, 9.64; CI, 24.64.
EXAMPLE 2 Bromo-2-hydroxy-3-methyl-6-pyridine 32 g. (0.2 M) of bromine in solution in 200 ml. of pyridine are poured onto 21.8 g. (0.2 M) of hydroxy-3- methyl-6-pyridine in solution in ml. of pyridine. The reaction is allowed to proceed for 5 hours at ambient temperature.
The solution is neutralized with'0.2 M of soda, and the pyridine is removed by steam distillation. Precipitates form in the remaining solution upon cooling. The precipitate is washed and dried. It is black, and its melting point is not well defined. It is dissolved in ml. of ethanol, and treated with bone black. After filtering and cooling the solution, a light beige precipitate is obtained.
An'alysis.-Calculated for CSHGBI'NO (percent): C, 38.29; H, 3.19; N, 7.44; Br, 42.44. Found (percent): C, 38.25; H, 3.02; N, 7.37; Br, 42.37.
3 EXAMPLE 3 Iodo-2-hydroxy-3-methyl-6-pyridine 109 g. (1 M) of hydroxy-3-methyl-6-pyridine are suspended in 500 ml. of distilled water containing 150 g. of sodium carbonate, 280 g. (1.1 M) of iodine are dissolved in 2 l. of distilled water by means of 280 g. of potassium iodide, and added to the suspension at ordinary temperature, after which the reaction is allowed to proceed for 2 hours at room temperature.
The resulting precipitate is filtered. It is then dissolved in 2 l. of soda solution containing 25 g./l., and treated at boiling with bone black for 15 minutes. After filtering, the solution is cooled, and then neutralized with 80 ml. of acetic acid.
The light beige precipitate thus obtained is filtered and dried.
Weight g 180 Melting point C 195-198 Yield "percent..- 77
Recrystallized in ethanol, it melts at 203 C.
Analysis.Calculated for C H INO (percent): C,
30.63; H, 2.55; N, 5.95; I, 54.04. Found (percent): C, 30.84; H, 2.46; N, 5.89; I, 54.17.
EXAMPLE 4 Chloro-2-hydroxy-3-nitro-4-methyl-6-pyridine n. or
N 10 m1. of red fuming nitric acid are added slowly to 14.35 g. (0.1 M) of chloro-2-hydroxy-3-methyl-6-pyridine dissolved in 50 ml. of strong sulfuric acid. The reaction mixture is then heated for 15 hours at 50 C. It is then poured onto 200 g. of cracked ice, and neutralized to pH 3 with 215 ml. of ammonia. The resulting yellow precipitate is filtered and dried.
Weight -d g 7 Melting point C 76 Yield percent" 37 H NLCI 12.5 g. (0.06 M) of phosphorus pentachloride are added in increments to 7.5 g. (0.04 M) of chloro-2-hydroxy-3-nitro-4-methyl-6-pyridine in solution in 50 ml. of phosphorus oxychloride. The solution is refluxed until the gas evolution ceases (30 minutes), and then allowed to stand overnight. It is then decomposed over 200 ml. of water, and neutralized with 210 ml. of strong soda. As the resulting precipitate is brown and has a very low melting point, it is recrystallized in 0 ml. of distilled water. Its melting point is then 138 C., but the yield of the reaction is very low: 11.2%. Weight obtained: 0.8 g.
Analysis-Calculated for C H Cl NO (percent): C, 40.44; H, 2.80; N, 7.86; CI, 39.88. Found (percent): C, 7. 2; C 3 .8.9.
4 EXAMPLE '6 O-O-dimethyl and 0-3 (iodo-2-methyl-6)pyridyl phosphate P-O CHaO The sodium ethoxide prepared from 0.7 g. (0.03 M) of sodium and 40 ml. of absolute alcohol is added to 7.05 g. of iodo-Z-hydroxy-3-methyl-6-pyridine (0.03 M) in solution in 40 ml. of absolute alcohol. The reaction is continued for one hour at room temperature. 4.35 g. of dimethylchlorophosphate (0.03 M) are then added at room temperature, and the mixture is refluxed for one hour.
The sodium chloride is filtered OE and the alcohol is removed. The residue is taken up with 100' ml. of chloroform, and washed once with m1. of 5% sodium bicarbonate, and twice with 80 m1. of distilled water, and then dried with magnesium sulfate. The chloroform is removed under water pump vacuum, and then under high vacuum during one hour. The oil thus obtained is of light brown color.
Analysis-Calculated for C H INO P (percent): C, 27.98; H, 3.20; N, 4.08; P, 9.03. Found (percent): C, 27.80; H, 3.3 0; N, 3.91; P, 8.89.
EXAIVIPLE 7 O-methyl and 0-3 (nitro-2-methyl-6)pyridyl methylphosphate CHzO CH3 N/ The sodium ethoxide prepared from 1.15 g. (0.05 M) of sodium and 40 ml. of absolute alcohol is added to 7.7 g. of nitro-2-hydroxy-3-methyl-6-pyridine (0.05 M) in solution in 40 ml. of absolute alcohol. The reaction is continued for one hour at room temperature. 6.4 g. (0.05 M) of O-methy1-methylchlorophosphinate are then added at ordinary temperature, after which the mixture is refluxed for one hour.
The sodium chloride is then filtered off, and the alcohol removed. The residue is taken up with ml. of chloroform, and washed once with 80 ml. of 5% sodium bicarbonate and twice with 80 ml. of distilled water, and then dried over magnesium sulfate. The chloroform is then removed, and a raw light yellow oil is obtained.
Weight g 8.8 1.5145 Yield percent 71.5
The sodium ethoxide, prepared from 0.9 g. (0.04 M) of sodium and 40 ml. of absolute alcohol, is added to 5.75 g. of chloro-2-hydroxy-3-methyl-6-pyridine (0.04
M) in solution in 40 ml. of absolute alcohol. The reaction is maintained for one hour at room temperature. 7.55 g. of diethylchlorothiophosphate (0.04 M) are then added at room temperature, and the mixture is then refluxed for one hour.
The sodium chloride is filtered otf and the alcohol removed. The residue is taken up with 100 ml. of chloroform and washed with 80 ml. of 5% sodium bicarbonate, and then twice with 80 ml. of distilled water. It is then dried over magnesium sulfate. The chloroform is then removed and the oil is distilled under high vacuum. The resulting oil (yield, 63.5%; Weight, 7.5 g.) has a very pale yellow color and the following physical constants:
Boiling point, 0.006 mm. Hg C-.. 112 20 1.5235
Analysis.-Calculated for C H CINO PS (percent): C, 40.61; H, 5.07; N, 4.73; P, 10.49. Found (percent): C, 40.86; H, 4.84; N, 4.78; P, 10.45.
EXAMPLE 9 O-ethyl and -3 (chloro-2-methyl-6)pyridyl dimethylamidophosphate CzHsO The sodium ethoxide prepared from 0.9 g. (0.04 M) of sodium and 40 ml. of absolute alcohol is added to 5.75 g. (0.04 M) of chloro-2-hydroxy-3-methyl-6-pyridine in solution in 40 ml. of absolute alcohol. The reaction is carried on for one hour at room temperature. 6.85 g. of ethyl-dimethylamido-chlorophosphate (0.04 M) are then added at room temperature, and the reaction mixture is then refluxed for one hour.
The sodium chloride is filtered, and the alcohol removed. The residue is taken up with 100 ml. of chloroform, and then washed once with 80 ml. of sodium bicarbonate and once with 80 ml. of distilled water. It is then dried over magnesium sulfate. The chloroform is then removed, and the oil is distilled under high vacuum. The resulting oil is colorless.
Analysis-Calculated for C H CIN O P (percent): C, 43.08; H, 5.74; N, 10.05; P, 11.13. Found (percent): C, 43.12; H, 6.04; N, 9.91; P, 11.12.
EXAMPLE 10 O-ethyland O-3 (ch1oro-2-methyl-6)pyridyl phenylthiophosphonate The sodium ethoxide prepared from 0.8 g. (0.035 M) of sodium and 40 ml. of absolute alcohol is added to 5 g. (0.035 M) of chloro-2-hydroxy-3-methyl-6-pyridine in solution in 40 ml. of absolute alcohol. The reaction is maintained for one hour at ordinary room temperature. 7.7 g. (0.035 M) of ethyl-phenylchlorothiophosphonate are then added at ordinary temperature, and the reaction mixture is refluxed for one hour.
The sodium chloride is filtered, and the alcohol removed. The residue is taken up with 100 ml. of chloroform, and washed once with 80 ml. of 5% sodium bicarbonate solution, and then with 80 ml. of distilled water. It is then dried over magnesium sulfate.
Analysis.Calculated for C H CINO PS (percent): C, 51.30; H, 4.58; N, 4.27; P, 9.46. Found (percent): C, 51.33; H, 4.63; N, 4.18; P, 9.48.
EXAMPLE l1 O-O-diethyl and O-3 (bromo-2-methyl-6)pyridyl phosphate CgHsO B 1' CH3 The sodium ethoxide prepared from 0.8 g. (0.035 M) of sodium and 40 ml. of absolute alcohol is added to 6.6 g. (0.035 M) of bromo 2-hydroxy-3-methyl-6-pyridine in soltuion in 40 ml. of absolute alcohol. The reaction is carried on for one hour at room temperature. 6.05 g. of diethylchlorophosphate 0.035 M) are then added at ordinary temperature, and the mixture is refluxed for one hour.
The sodium chloride is filtered, and the alcohol removed. The residue is taken up with 100 ml. of chloroform, and then washed with ml. of 5% sodium bicarbonate, after which it is washed again with 80 ml. of distilled water and dried over magnesium sulfate. The chloroform is removed, and the resulting oil is kept raw.
Analysis.--Calculated for C H BrNO P (percent): C, 37.03; H, 4.63; N, 4.32; P, 9.56. Found (percent): C, 36.95; H, 4.96; N, 4.30; P, 9.48.
EXAMPLE 12 O-O-diethyl and O-3 (chloro-2-nitro-4-methyl-6)pyridyl phosphate N/ CH3 The sodium ethoxide prepared from 0.8 g. (0.035 M) of sodium and 40 ml. of absolute alcohol is added to 6.6 g. (0.035 M) of chloro 2-hydroxy-3-nitro-4-methyl-6-pyridine in solution in 40 ml. of absolute alcohol. The reaction is carried on for one hour'at ordinary temperature. 6.05 g. (0.035 M) of diethylchlorophosphate are then added at room temperature, and the mixture is then refluxed for one hour.
The sodium chloride is filtered, and the alcohol removed, as by distillation. The residue is then taken up with ml. of chloroform, and washed with 80 ml. of 5% sodium bicarbonate, after which it is washed again with 80 ml. of distilled water and dried over magnesium sulfate.
The chloroform is then removed, and the resulting oil is kept raw. It is orange yellow, and its index is:
zo 1.4915 Weight g 7.9 Yield percent 69.5
Compounds corresponding to the formula:
X Y i -o Rso I R N/ H:
P wmeuuwwumn a wwwemmuwfigm m m an smmamomsnnn 9 amummm m wnwnmnn & 9 &&7 7 7 6 7 &8 &&& 7. & n N mmmmwumumw nmmmwemeuemmm e mgnmmnwmmmmm m n mm m M980m88 hmm 8 8 -&4- -4-5 Rw5 & A 43&&3.3.&&7.4-A-&4- 3 3 &m 0 r n mmomunwmmw w momnmwmuwwnmm m nmmwmmnwmnmw m a no 75&&5 &6 4-4-5 an in fiu iifififlflin fi 4 a uz kiiaqmn knmomno 3 3 k5 c asse s m s sses .s w oofing o ownwmenemfiee o umnmmu nmunwm m w m 1 m P omen nnmmm mmomnwmmmmwm memmmowuwmnmw w n no u m mm wosn un 9 owmnmmm mmomnmn om om&8 7 7 7 7 7 &&uwo& 7 7 own m N mewmnwmmm M an mweumunmunm w wwmmmmwmwnnmm n n on m MHQFmo nuRWMQQ em Rwl 5 4 m4-4-4-4-5 .m5 0 A iaomomaanaomlomkiqu 3 2m &0 m 11 1 1 1 c w H mummmmmou m. onwmmnwnwmwun u wuwmmnaemmmmw m m we esssssseas e nssssessosess 4 nnasnnszeeaaa a a o mwwnmunum 1 mmmmmmmmmmmmm n mnmmmmuwnmenn m w on u ownwwwnomemwe o mmnmwuwwwnwwm m n n "a "s 81 u "a u n n m m mm mwmmmww. mm. .mw. m m .m .QO. .0.O.0.0.O.I1./ LII. m w New wwwwwm mm m m m n u 11 -1 1 u u l m moo mmommm mm 5 m m w vmommmmfiwmsm who w e um L LLLQLLLLLLLIL LLL L L LL m n nnnnnnnnnnnnn n nnnnnnnnnnnnn n n NH 04 nlnl 0 001111 1 N N NNOCCCWCQQQQU. 1C1 QIIIIIIIIIIII I I ..C..C n 2 m w 11 11 so... mmmm. 1 21 mm m 1 m m fimmwsemmmfi m mmnwwwwwmnmmm m "M em 0 CCGCC BunCCCC 0 CCC uh.. nCCCOCC C C CO H n n u n u 0 m 00 m m m 00 1 11 C oo mn m OO HH 00 5 -b e H sn hm mnmmnwwmmmnn mmmmwwo w mnnn an SCCCCEEnnCCnYk 800 um nC(CCCC CC 8 S s S n n n m n n n n n .u n u u q p s w CHQO cdiho XCH:
EXAMPLE .13
Test on Musca domestica Ten adult flies, 4-5 days old, are disposed in a Pet ox provided with a netting lid. The box is treated di- 55 Compound 0 Compound D both in the laboratory and in greenhouses. The followin examples, which are not restrictive, describe the experimentation conditions and the results obtained, with the compounds of this invention as compared with known compounds hav Compound A Compound B fectly by spraying thereon cc. of a solution in acetone of the active material to be tested.
The numbers of flies dead and alive are counted one hour after the treatment. Under such conditions, products Nos. 8, 9, 14, 15, 16, 21, 22, 23 and 42 give 100% mortality for the flies with a concentration of 0.05 g./l., and products Nos. 3, 10, 13, 27, and 37 give 100% mortality at a concentration of 0.1 g./l. By way of comparison, known Compounds A and B require a concentration of 0.5 g./l. to obtain a similar result. Under the same conditions, DDT requires a concentration of 1 g./l. to obtain a similar result.
EXAMPLE 14 Test on Ephestia kuhnielle A few drops (3) of an acetone solution of the active material to be tested are deposited onto an azyme cachet. The acetone is then allowed to evaporate, and eggs of Ephestia kuhnielle are disposed on said cachet, and covered with a glass plate to prevent any escape. A mortality check is efiected 10 days later.
Under such conditions, products Nos. 9 and 40 give 100% mortality at a concentration of 0.0005 g./l. Products Nos. 3, 11, 12, 21 and 26 give 100% mortality at a concentration of 0.001 g./l. By way of comparison, known Compounds A and C require a concentration of 0.01 g./l. for obtaining an 80% mortality, and Compounds B and C require a concentration of 0.1 g./1. for obtaining 100% mortality Among the insecticide compounds widely used heretofore, DDT and a-naphthyl N-methylcarbamate (carbaryl) require a concentration of 0.1 g./l. in order to obtain a similar result.
EXAMPLE 15 Test on Tetranychus urticae Bean plants infested with Tetranychus urticae are treated directly by means of a compressed air sprayer filled with a solution of the active material to be tested. The mortality check is made by comparison with a reference series of untreated bean plants.
Under such conditions, at a concentration of 50 g./hl., Compounds Nos. 3, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 19, '22, 23, 24, 25, 26, 36, 37 and 40 bring about a 100% mortality of the Acaridae.
EXAMPLE 16 Test on Blatella germamca Five adult cockroaches are disposed in a Petri box provided with a netting lid. The box is treated directly by means of a spraying tower which sprays 5 cc. of an acetone solution of the active material being tested, at various concentrations. The resulting mortality obtained after treatment is then noted.
Under such conditions, Compounds Nos. 3, 5, 8, 10, 15, 21, 22 and 42 give 100% mortality among the cockroaches at a concentration of 0.1 g./l. Under the same conditions, known Compounds A and B require a concentration of l g./I. to obtain the same result. Under the same conditions, well-known insecticides, such as azinphosethyl [0,0 diethyl S-(4, oxo l, 2, 3 benzotriazin-3 {4 H]y1 methyl)phosphorodithicate], malathion [S 1, 2 di(ethoxycarbonyl)ethyl dimethylphosphorothiolothionate], or ronnel [0,0 dimethyl O-(2,3,4-trich1orophenyl) phosphorothioate] should be used at concentrations of the order of one gram/liter to bring about a complete destruction of cockroaches.
EXAMPLE 17 Test on Coenorhabditis elegans 10 cc. of a solution of the compound to be tested are poured into a 250 cc. screw-cap powder-box. 3-4 drops of a concentrated suspension of nematodes (Coenorhabditis elegans) 4 days old, are then added. After 48 hours,
a check for the mortality rate is effected by means of a binocular magnifying glass.
Under such conditions, products Nos. 1, 3, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 19, 20, 21, 22, 23, 25 and 37 give mortality of the nematodes at a concentration of 0.1 g./l.
Under the same conditions, but at a concentration ten times less (0.01 g./l.), products Nos. 3, 7, 8, 10, 14, 15, 16, 19, 21, 22 and 42 give 100% mortality of the nematodes.
For all practical purposes, the compounds of this invention should seldom be used in the pure state, except for very low volume applications (U.L.V. treatments). Most often, these active materials are mixed with various ad juvants and carriers, or liquid and/or solid diluents, so as to obtain formulations suitable for the utilization requirements and the character of the problem to be solved. Such formulations may be employed in the form of granules, powdering powders, wettable powders or solutions adapted to be emulsified. The preparation of such formulations pertains to well-known techniques, which are, in particular, described in published works such as Chemistry of the Pesticides, by D. E. H. Frear, 3rd ed., pp. 409'- The polyvalent action of the compounds of this invention enables them to be used in fighting against the parasites of various crops in the agicultural, arboricultural and viticultural fields, as well as in the household or public health fields.
It will be understood that changes may be made in the details of formulations and operation without departing from the spirit of the invention, especially as defined in the following claims.
We claim: 1. A compound having the formula \P---O R20/ R wherein R is selected from the group consisting of C to C alkyl, C to C haloalkyl, C to 0., alkoxy, phenyl and phenoxy; R is C to C alkyl or C to C haloalkyl; R is halogen, R is hydrogen and X is S or O.
2. A compound as defined in claim 1 wherein R is C to 0., alkyl and R is C to 0., alkyl.
3. A compound having the formula i -o R20 I R N/ CH:
5. A compound as defined in claim 3 wherein the compound has the formula C zHy- 0 01 on, N
11 12 6. A compound as defined in claim 3 wherein the com- 9. A compound as defined in claim 3 wherein the compound has the formula pound has the formula 63H; cmol-cm-o (J r -o P-0 o,m0 G1 I 5 CH:CICH:O I m 7. A compound as defined in claim 3 wherein the com- References Cited pound has the formula UNITED STATES PATENTS @fi 3,478,037 11/1969 Fest et a1. 260-294.8 K P 3,669,975 6/1972 Demosay et a1. 260-294.8 K CHPO/ 1 3,535,325 10/1970 Gubler et al. 260294.9 K
N ALAN L. ROTMAN, Primary Examiner 8. A compound as defined in claim 3 wherein the com- I U 8 C1 X R pound has the formula 71-94; 260-496 R, 297 P; 424-263 @i /P-O I 2 5-0 01
US00157636A 1970-06-30 1971-06-28 Certain pyridylphosphates,thiophosphates,phosphonates and thiophosphonates Expired - Lifetime US3790582A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7024078A FR2094678A5 (en) 1970-06-30 1970-06-30

Publications (1)

Publication Number Publication Date
US3790582A true US3790582A (en) 1974-02-05

Family

ID=9057990

Family Applications (1)

Application Number Title Priority Date Filing Date
US00157636A Expired - Lifetime US3790582A (en) 1970-06-30 1971-06-28 Certain pyridylphosphates,thiophosphates,phosphonates and thiophosphonates

Country Status (16)

Country Link
US (1) US3790582A (en)
BE (1) BE769143A (en)
CA (1) CA929163A (en)
CH (1) CH537955A (en)
CS (1) CS167320B2 (en)
DE (1) DE2132590A1 (en)
DK (1) DK131783C (en)
ES (1) ES392756A1 (en)
FR (1) FR2094678A5 (en)
GB (1) GB1361224A (en)
HU (1) HU163023B (en)
IL (1) IL37048A (en)
NL (1) NL7109062A (en)
OA (1) OA03749A (en)
SU (1) SU472508A3 (en)
ZA (1) ZA714096B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957801A (en) * 1972-10-13 1976-05-18 Ciba-Geigy Corporation O,s-dialkyl esters of pyridylthio- and pyridyldithiophosphoric acid
US3968222A (en) * 1972-10-13 1976-07-06 Ciba-Geigy Corporation Insecticidal O,S-dialkyl esters of pyridylthio-and-pyridyldithio-phosphoric acids
US4251663A (en) * 1979-02-05 1981-02-17 Merck & Co., Inc. Thiosubstituted pyridines
US4900732A (en) * 1980-01-23 1990-02-13 Allen Berenter Method of treating American and Oriental cockroaches
US5036059A (en) * 1984-04-19 1991-07-30 Nippon Shinyaku Company, Limited 1,4-Dihydropyridine-3-carboxylate derivatives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957801A (en) * 1972-10-13 1976-05-18 Ciba-Geigy Corporation O,s-dialkyl esters of pyridylthio- and pyridyldithiophosphoric acid
US3968222A (en) * 1972-10-13 1976-07-06 Ciba-Geigy Corporation Insecticidal O,S-dialkyl esters of pyridylthio-and-pyridyldithio-phosphoric acids
US4251663A (en) * 1979-02-05 1981-02-17 Merck & Co., Inc. Thiosubstituted pyridines
US4900732A (en) * 1980-01-23 1990-02-13 Allen Berenter Method of treating American and Oriental cockroaches
US5036059A (en) * 1984-04-19 1991-07-30 Nippon Shinyaku Company, Limited 1,4-Dihydropyridine-3-carboxylate derivatives

Also Published As

Publication number Publication date
IL37048A0 (en) 1971-08-25
DK131783C (en) 1976-02-02
SU472508A3 (en) 1975-05-30
ES392756A1 (en) 1973-08-01
DE2132590A1 (en) 1972-01-05
DK131783B (en) 1975-09-01
OA03749A (en) 1971-12-24
GB1361224A (en) 1974-07-24
CS167320B2 (en) 1976-04-29
CH537955A (en) 1973-06-15
BE769143A (en) 1971-11-03
ZA714096B (en) 1972-03-29
CA929163A (en) 1973-06-26
IL37048A (en) 1974-05-16
FR2094678A5 (en) 1972-02-04
NL7109062A (en) 1972-01-03
HU163023B (en) 1973-05-28

Similar Documents

Publication Publication Date Title
US2908605A (en) New organic phosphorus compounds and process for their manufacture
US3153663A (en) Phosphoric (phosphonic, phosphinic) or thiophosphoric (-phosphonic, -phosphinic) acidesters and processes for their production
US3790582A (en) Certain pyridylphosphates,thiophosphates,phosphonates and thiophosphonates
US2885430A (en) Bis-(o:o-diethyl-dithiophosphoryl) 1:4-butylene-dimethyl ether
US3591600A (en) 2-aminothiazole phosphates and phosphonates
US3696103A (en) Azaborolidine compounds
US3232951A (en) Phosphoric, phosphonic and phosphinic acid esters of 3-hydroxybenzisazoles, and their thio analogues
US3555123A (en) Di-omega-alkynyl aryl(arylalkyl) phosphonates
US3714350A (en) Phosphoryl and thiophosphoryl pyrones as insecticides
US3694451A (en) Certain 2-phosphorylimino-4-thiazolines
US3197365A (en) Insecticidal and nematocidal phosphinyl imides
US4225595A (en) Piperazine phosphates and phosphonate insecticides
US2891887A (en) Dialkyl 1, 3-di(carbalkoxy)-1-propen-2-ylphosphate pesticides
US3368002A (en) S-chlorophenoxymethyl thio, dithio phosphonates or phosphates
US3524861A (en) Phosphorylated benzofurazans
US3364230A (en) Novel phosphorylated 2-imino-1, 3-dithioles
US2752283A (en) Phosphorus derivatives, process for their preparation and compositions containing them
US3475452A (en) Phosphates and phosphonates of cyclic sulfones
US3107164A (en) Herbicidal methods employing omicron, omicron-diallyl omicron-aryl phosphate esters
EP0150822B1 (en) Oximinophosphoric acid derivatives, process for their preparation and their use as pesticides
CA1064938A (en) Organophosphorus compounds useful as insecticides and acaricides
US3281430A (en) Oxathiolanes and related compounds
US3755571A (en) Use of substituted 1,2,4-thiadiazoles for killing insects
US3248458A (en) Organic phosphorus esters and anhydrides
US3929805A (en) Certain 4H-(2,3d)pyrido-1,3,2-dioxaphosphorinanes