US3137632A - Chlorophyll dentifrice compositions - Google Patents

Chlorophyll dentifrice compositions Download PDF

Info

Publication number: US3137632A
Authority: US; United States
Prior art keywords: acid; water soluble; chlorophyll; water; compositions
Prior art date: 1952-02-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

US272525A

Other languages

English (en)

Inventor

Schiraldi Robert Joseph

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Colgate Palmolive Co

Original Assignee

Colgate Palmolive Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1952-02-19

Filing date

1952-02-19

Publication date

1964-06-16

Priority to BE516996D priority Critical patent/BE516996A/xx

1952-02-19 Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co

1952-02-19 Priority to US272525A priority patent/US3137632A/en

1952-11-07 Priority to GB28159/52A priority patent/GB708232A/en

1952-11-10 Priority to FR1066412D priority patent/FR1066412A/fr

1952-11-14 Priority to CH316281D priority patent/CH316281A/de

1953-01-08 Priority to DEC6922A priority patent/DE968516C/de

1964-06-16 Application granted granted Critical

1964-06-16 Publication of US3137632A publication Critical patent/US3137632A/en

1981-06-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims description 64
239000000551 dentifrice Substances 0.000 title claims description 32
229930002875 chlorophyll Natural products 0.000 title claims description 16
235000019804 chlorophyll Nutrition 0.000 title claims description 16
ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 title description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 60
-1 CHLOROPHYLL COMPOUND Chemical class 0.000 claims description 29
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
229910052783 alkali metal Inorganic materials 0.000 claims description 17
RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 14
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 14
229940043430 calcium compound Drugs 0.000 claims description 12
150000001674 calcium compounds Chemical class 0.000 claims description 12
XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical class OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 claims description 9
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Chemical class OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 7
235000015165 citric acid Nutrition 0.000 claims description 7
239000000174 gluconic acid Chemical class 0.000 claims description 7
235000012208 gluconic acid Nutrition 0.000 claims description 7
235000011007 phosphoric acid Nutrition 0.000 claims description 7
229940005657 pyrophosphoric acid Drugs 0.000 claims description 7
235000012239 silicon dioxide Nutrition 0.000 claims description 7
239000002195 soluble material Substances 0.000 claims description 7
UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical class OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims description 7
150000001340 alkali metals Chemical class 0.000 claims description 2
VYTBPJNGNGMRFH-UHFFFAOYSA-N acetic acid;azane Chemical compound N.N.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O VYTBPJNGNGMRFH-UHFFFAOYSA-N 0.000 claims 1
LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical class O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims 1
RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 14
239000000463 material Substances 0.000 description 13
239000003795 chemical substances by application Substances 0.000 description 11
238000005498 polishing Methods 0.000 description 11
239000004615 ingredient Substances 0.000 description 9
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 8
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical class OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 7
229960001484 edetic acid Drugs 0.000 description 7
229940099898 chlorophyllin Drugs 0.000 description 6
235000019805 chlorophyllin Nutrition 0.000 description 6
UVVWIYVATLQAFM-UHFFFAOYSA-I copper;tripotassium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,13,17-trimethyl-8-(oxidomethylidene)-17,18-dihydroporphyrin-21-ide-2-carboxylate Chemical compound [K+].[K+].[K+].[Cu+2].C1=C([N-]2)C(C)=C(C([O-])=O)C2=C(CC([O-])=O)C(C(C2C)CCC([O-])=O)=NC2=CC(C(=C2C=C)C)=NC2=CC\2=NC1=C(CC)C/2=C\[O-] UVVWIYVATLQAFM-UHFFFAOYSA-I 0.000 description 6
HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 description 6
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical class O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 6
229940079841 sodium copper chlorophyllin Drugs 0.000 description 6
235000013758 sodium copper chlorophyllin Nutrition 0.000 description 6
FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 6
235000019818 tetrasodium diphosphate Nutrition 0.000 description 6
239000003599 detergent Substances 0.000 description 5
239000003921 oil Substances 0.000 description 5
235000019198 oils Nutrition 0.000 description 5
235000019832 sodium triphosphate Nutrition 0.000 description 5
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
239000011230 binding agent Substances 0.000 description 4
229910000019 calcium carbonate Inorganic materials 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
235000019820 disodium diphosphate Nutrition 0.000 description 4
GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 4
229940038485 disodium pyrophosphate Drugs 0.000 description 4
239000000843 powder Substances 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
244000246386 Mentha pulegium Species 0.000 description 3
235000016257 Mentha pulegium Nutrition 0.000 description 3
235000004357 Mentha x piperita Nutrition 0.000 description 3
239000012736 aqueous medium Substances 0.000 description 3
239000001506 calcium phosphate Substances 0.000 description 3
235000001050 hortel pimenta Nutrition 0.000 description 3
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
239000000344 soap Substances 0.000 description 3
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
UBLAMKHIFZBBSS-UHFFFAOYSA-N 3-Methylbutyl pentanoate Chemical compound CCCCC(=O)OCCC(C)C UBLAMKHIFZBBSS-UHFFFAOYSA-N 0.000 description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
241000206575 Chondrus crispus Species 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
239000004115 Sodium Silicate Substances 0.000 description 2
239000002671 adjuvant Substances 0.000 description 2
230000001680 brushing effect Effects 0.000 description 2
239000001768 carboxy methyl cellulose Substances 0.000 description 2
235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
239000008112 carboxymethyl-cellulose Substances 0.000 description 2
235000011180 diphosphates Nutrition 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
238000009472 formulation Methods 0.000 description 2
239000002198 insoluble material Substances 0.000 description 2
239000007788 liquid Substances 0.000 description 2
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
229940048084 pyrophosphate Drugs 0.000 description 2
239000002002 slurry Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011734 sodium Substances 0.000 description 2
235000010413 sodium alginate Nutrition 0.000 description 2
239000000661 sodium alginate Substances 0.000 description 2
229940005550 sodium alginate Drugs 0.000 description 2
239000001509 sodium citrate Substances 0.000 description 2
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 2
229910052911 sodium silicate Inorganic materials 0.000 description 2
239000000271 synthetic detergent Substances 0.000 description 2
239000004408 titanium dioxide Substances 0.000 description 2
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
229940078499 tricalcium phosphate Drugs 0.000 description 2
229910000391 tricalcium phosphate Inorganic materials 0.000 description 2
235000019731 tricalcium phosphate Nutrition 0.000 description 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
239000009637 wintergreen oil Substances 0.000 description 2
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
206010006326 Breath odour Diseases 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
235000019739 Dicalciumphosphate Nutrition 0.000 description 1
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
244000004281 Eucalyptus maculata Species 0.000 description 1
206010063560 Excessive granulation tissue Diseases 0.000 description 1
244000024873 Mentha crispa Species 0.000 description 1
235000014749 Mentha crispa Nutrition 0.000 description 1
235000007265 Myrrhis odorata Nutrition 0.000 description 1
206010055670 Necrotising ulcerative gingivostomatitis Diseases 0.000 description 1
208000006595 Necrotizing Ulcerative Gingivitis Diseases 0.000 description 1
235000019482 Palm oil Nutrition 0.000 description 1
240000004760 Pimpinella anisum Species 0.000 description 1
235000012550 Pimpinella anisum Nutrition 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
HLCFGWHYROZGBI-JJKGCWMISA-M Potassium gluconate Chemical compound [K+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O HLCFGWHYROZGBI-JJKGCWMISA-M 0.000 description 1
239000004111 Potassium silicate Substances 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
244000223014 Syzygium aromaticum Species 0.000 description 1
235000016639 Syzygium aromaticum Nutrition 0.000 description 1
240000002657 Thymus vulgaris Species 0.000 description 1
235000007303 Thymus vulgaris Nutrition 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
JHSMLTNVGZQXAF-UHFFFAOYSA-N [Cu].[Na].[K] Chemical compound [Cu].[Na].[K] JHSMLTNVGZQXAF-UHFFFAOYSA-N 0.000 description 1
DYPHJEMAXTWPFB-UHFFFAOYSA-N [K].[Fe] Chemical compound [K].[Fe] DYPHJEMAXTWPFB-UHFFFAOYSA-N 0.000 description 1
FJAAKDGALOFQSO-UHFFFAOYSA-N [K].[Ni] Chemical compound [K].[Ni] FJAAKDGALOFQSO-UHFFFAOYSA-N 0.000 description 1
238000005299 abrasion Methods 0.000 description 1
229910000318 alkali metal phosphate Inorganic materials 0.000 description 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
229940095564 anhydrous calcium sulfate Drugs 0.000 description 1
239000002585 base Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
238000004040 coloring Methods 0.000 description 1
239000006071 cream Substances 0.000 description 1
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
229940038472 dicalcium phosphate Drugs 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
CQAIPTBBCVQRMD-UHFFFAOYSA-L dipotassium;phosphono phosphate Chemical compound [K+].[K+].OP(O)(=O)OP([O-])([O-])=O CQAIPTBBCVQRMD-UHFFFAOYSA-L 0.000 description 1
201000010099 disease Diseases 0.000 description 1
OGMQNMUHVLRDRT-UHFFFAOYSA-J disodium;3-[20-(carboxylatomethyl)-18-(dioxidomethylidene)-8-ethenyl-13-ethyl-3,7,12,17-tetramethyl-2,3-dihydroporphyrin-23-id-2-yl]propanoate;hydron;iron(2+) Chemical compound [H+].[Na+].[Na+].[Fe+2].C1=C([N-]2)C(CC)=C(C)C2=CC(C(=C2C)C=C)=NC2=CC(C(C2CCC([O-])=O)C)=NC2=C(CC([O-])=O)C2=NC1=C(C)C2=C([O-])[O-] OGMQNMUHVLRDRT-UHFFFAOYSA-J 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
238000005187 foaming Methods 0.000 description 1
208000024693 gingival disease Diseases 0.000 description 1
208000007565 gingivitis Diseases 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
210000001126 granulation tissue Anatomy 0.000 description 1
230000035876 healing Effects 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
238000011835 investigation Methods 0.000 description 1
NEMFQSKAPLGFIP-UHFFFAOYSA-N magnesiosodium Chemical compound [Na].[Mg] NEMFQSKAPLGFIP-UHFFFAOYSA-N 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
SWHAQEYMVUEVNF-UHFFFAOYSA-N magnesium potassium Chemical compound [Mg].[K] SWHAQEYMVUEVNF-UHFFFAOYSA-N 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
FPBMTPLRBAEUMV-UHFFFAOYSA-N nickel sodium Chemical compound [Na][Ni] FPBMTPLRBAEUMV-UHFFFAOYSA-N 0.000 description 1
239000002540 palm oil Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
201000001245 periodontitis Diseases 0.000 description 1
150000004033 porphyrin derivatives Chemical class 0.000 description 1
229960003975 potassium Drugs 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
239000001508 potassium citrate Substances 0.000 description 1
229960002635 potassium citrate Drugs 0.000 description 1
QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
235000011082 potassium citrates Nutrition 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
239000004224 potassium gluconate Substances 0.000 description 1
235000013926 potassium gluconate Nutrition 0.000 description 1
229960003189 potassium gluconate Drugs 0.000 description 1
NNHHDJVEYQHLHG-UHFFFAOYSA-N potassium silicate Chemical compound [K+].[K+].[O-][Si]([O-])=O NNHHDJVEYQHLHG-UHFFFAOYSA-N 0.000 description 1
235000019353 potassium silicate Nutrition 0.000 description 1
229910052913 potassium silicate Inorganic materials 0.000 description 1
229940074415 potassium silicate Drugs 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
229960001790 sodium citrate Drugs 0.000 description 1
235000011083 sodium citrates Nutrition 0.000 description 1
239000000176 sodium gluconate Substances 0.000 description 1
235000012207 sodium gluconate Nutrition 0.000 description 1
229940005574 sodium gluconate Drugs 0.000 description 1
229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
229940032158 sodium silicate Drugs 0.000 description 1
235000019794 sodium silicate Nutrition 0.000 description 1
UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
239000001585 thymus vulgaris Substances 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
235000019798 tripotassium phosphate Nutrition 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
235000019801 trisodium phosphate Nutrition 0.000 description 1
229910000406 trisodium phosphate Inorganic materials 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/58—Metal complex; Coordination compounds

Definitions

Chlorophyll the green coloring material found in plants, is a water insoluble phytyl methyl ester of a porphyrin derivative.
the water insoluble material may be converted to a water soluble material by saponification, for example, with a water soluble alkali metal base.
the product thus obtained is a water soluble alkali metal salt, i.e., a water soluble chlorophyll compound.
the Water soluble chlorophyll compounds may be introduced into the mouth advantageously by brushing the teeth with the aid of a dentrifrice composition containing the said compounds.
Experimental determinations indicate, however, that Water soluble chlorophyll compounds are not released in water solutions from dentrifrice compositions which contain such chlorophyll compounds and polishing agents such as Water insoluble calcium compounds.
these determinations indicate that the chlorophyll compounds are not released in the aqueous media of the human mouth when such dentifrice compositions are used for brushing the teeth.
the present invention is based upon the surprising discovery that dentifrice compositions containing water soluble chlorophyll compounds and water insoluble calcium compounds as polishing agents can be prepared from which the chlorophyll compounds are released when the compositions are employed in the aqueous media of the human mouth.
the novel dentifrice compositions of the present invention comprise at least one water insoluble calcium compound, a water soluble chlorophyll compound, and a watersoluble material selected from the group consisting of alkali metal salts of orthophosphoric acid, pyrophosphoric acid, tripolyphosphoric acid, citric acid, silicic acid, gluconic acid, and ethylene diamine tetraacetic acid.
the pH of the compositions should be within the range of about to 11 based upon a 20% water slurry of the composition.
Suitable water soluble -alkali metal salt materials which may be employed in the dentifrice compositions of this invention include mono--, di-, and tri-sodium phosphate, disodium pyrophosphate, tetrasodium pyrophosphate, sodium tripolyphosphate, mono-, di-, and tri-potassium phosphate, dipotassium pyrophosphate, tetrapotassiurn pyrophosphate, potassium tripolyphosphate, sodium citrate, sodium gluconate, sodium silicate, potassium citrate, potassium gluconate, potassium silicate, etc.
the alkali metal salts may be emfee.
the sodium salts are preferably used because of their relatively low cost.
the water insoluble calcium compounds used as polishing agents in the dentifrice compositions of this invention may be selected from a relatively large number of materials.
Representative materials include, for example, calcium carbonate, calcium sulfate, anhydrous dicalcium phosphate, dicalcium phosphate dihydrate, commercial tricalcium phosphate, etc. If desired, these materials may be replaced in minor amounts by other Water insoluble materials, e.g., aluminum hydroxide, magnesium carbonate, etc.
the water insoluble polishing agent should be incorporated in the compositions in an appreciable amount and preferably should constitute the major proportion of the compositions, amounting to about 20% to by Weight of the finished dentifrice by weight.
the Water soluble chlorophyll compounds used in the dentifrice compositions herein described include those compounds known technically as sodium copper chlorophyllin, sodium magnesium chlorophyllin, sodium nickel chlorophyllin, sodium iron chlorophyllin, sodium potassium copper chlorophyllin, potassium copper chlorophyllin, potassium magnesium chlorophyllin, potassium nickel chlorophyllin, potassium iron chlorophyllin, etc.
the water soluble chlorophyll compounds should be present in the composition in amounts up to about 1.0% by weight of the final composition.
dentifrice compositions were prepared contain ing the various water insoluble calcium com ounds as polishing agents and the varying amounts of the several different water soluble alkali metal salts indicated in the table. Each one of the compositions contained 0.1% of water soluble potassium copper chlorophyllin. The values given in the table indicate the percent of the water soluble chlorophyll compound released when the compositions were mixed with water in the ratio of about one part of the dentifrice composition for four parts of Water.
the novel compositions of this invention may contain certain additional ingredients.
the dentifrice compositions ordinarily will contain a detergent or cleansing ingredient.
the amount of detergent and the particular detergent used may be the same as employed in conventional dentifrice preparations. Examples of suitable materials include soaps, i.e., water soluble salts of higher fatty acids, as well as synthetic detergents.
the amount of detergent used depends upon the particular one selectedand upon the amount of foaming action desired in the product. For example, if ordinary soaps are employed they may be used in amounts up to about of the final composition whereas such materials as synthetic detergents may be used in amounts up to about 8% of the final composition.
flavoring materials may be used to impart a pleasant taste to the compositions and to render the same more palatable.
Suitable flavoring materials include oil of Wintergreen, oil. of peppermint, oil of spearmint, oil of eucalyptus, cloves, menthol, anise, thyme, soluble saccharine, etc.
Example I A dentifrice composition in paste form comprises:
This composition has a pH of approximately 7.5.
Example II A dentifrice composition in paste form comprises:
This composition has a pH of approximately 8.0.
Example III A dentifrice composition in paste form comprises:
This composition has a pH of approximately 8.5.
This composition has a pH of approximately 8.8,
Example V A dentifrice composition in powder form comprises:
This composition has a pH of approximately 10.8.
Example VI A dentifrice composition in powder form comprises:-
This composition has a pH of approximately 8.5.
certain adjuvant materials may be incorporated in minor amounts in the novel compositions herein described.
a binder or thickening agent may be present.
the amount of binder used depends largely upon the particular material selected. If sodium alginate is used as the binder, it advantageously may be used in amounts up to about 3% of the final composition. Gum tragacanth may be used in amounts ranging from about 0.1% up to about 3%, based upon the finished product, while carboxymethyl cellulose may be used in even larger amounts, e.g., up to about 4% or even a little more.
such binders. as Irish moss and pectin may be used in relatively widely varied proportions.
ingredients such as titanium dioxide may be incorporated in the composition in amounts ranging up to about 2.0% to lighten the color of the finished composition.
the present invention in the broadest aspects thereof, contemplates .the formulation of the novel dentifrice compositions in any desired physical form, e.g., in an aqueous form such as a cream or paste; as a dry powder; etc.
a powdered dentifrice composition may be prepared readily and simply by mixingthe ingredients in the proper proportions in any desired order.
liquid ingredients e.g., water, ethanol and the like
the water soluble alkali metal salt material is added to the mixture after which the polishing agent, water soluble chlorophyll compound, and any desired adjuvant ingredients (flavoring ingredients, titanium dioxide, etc.) are introduced.
a detergent is employed in the composition itpreferably is introduced into the thoroughly mixed liquid ingredients prior to the introduction of the water soluble alkali metal salt.
a dentifrice composition comprising at least one water insoluble calcium compound, a water soluble chlorophyll compound, and a water soluble material selected from the group consisting of alkali metal salts of orthophosphoric acid, pyrophosphoric acid, tripolyphosphoric acid, citric acid, silicic acid, gluconic acid, and ethylene diamine tetraacetic acid.
a dentifrice composition comprising at least one water insoluble calcium compound, amounts up to about 1% of a water soluble chlorophyll compound, and a water soluble material selected from the group consisting of alkali metal salts of orthophosphoric acid, pyrophosphoric acid, tripolyphosphoric acid, citric acid, silicic acid, gluconic acid, and ethylene diamine tetraacetic acid.
a dentifrice composition comprising a polishing agent consisting essentially of at least one water insoluble calcium compound, small amounts up to about 1% of a water soluble chlorophyll compound, and a water soluble material selected from the group consisting of alkali metal salts of orthophosphoric acid, pyrophosphoric acid, tripolyphosphoric acid, citric acid, silicic acid, gluconic acid, and ethylene diamine tetraacetic acid.
a dentifrice composition in paste form comprising amounts up to about 1% of a Water soluble chlorophyll compound, about 20% to 95% of dicalcium phosphate dihydrate, a water soluble material selected from the group consisting of alkali metal salts of orthophosphoric acid, pyrophosphoric acid, tripolyphosphoric acid, citric acid, silicic acid, gluconic acid, and ethylene diamine tetraacetic acid.
a dentifrice composition in powder form comprising amounts up to about 1% of sodium copper chlorophyllin,
a polishing agent consisting essentially of dicalcium phosphate dihydrate, amounts of up to about 10% of a water soluble material selected from the group consisting of alkali metal salt of orthophosphoric acid, pyrophosphoric acid, tripolyphosphoric acid, citric acid, silicic acid, gluconic acid, and ethylene diamine tetraacetic acid.
a dentifrice composition comprising amounts up to about 1% of a water soluble chlorophyll compound, about 20% to 95% of a polishing agent consisting essentially of an insoluble inorganic calcium compound, and amounts up to about 10% of an alkali metal salt of ethylene diamine tetraacetic acid.
a dentifrice composition comprising amounts up to about 1% of a water-soluble chlorophyll compound, from about 20% to about 95% of a polishing agent consisting essentially of a water-insoluble inorganic calcium compound, and amounts up to about 10% of a water-soluble alkali metal phosphate.

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Birds (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Cosmetics (AREA)

US272525A 1952-02-19 1952-02-19 Chlorophyll dentifrice compositions Expired - Lifetime US3137632A (en)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
BE516996D BE516996A (hu)	1952-02-19
US272525A US3137632A (en)	1952-02-19	1952-02-19	Chlorophyll dentifrice compositions
GB28159/52A GB708232A (en)	1952-02-19	1952-11-07	Dentifrice compositions
FR1066412D FR1066412A (fr)	1952-02-19	1952-11-10	Compositions dentifrices contenant de la chlorophylle
CH316281D CH316281A (de)	1952-02-19	1952-11-14	Zahnpflegemittel
DEC6922A DE968516C (de)	1952-02-19	1953-01-08	Zahnpflegemittel

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US272525A US3137632A (en)	1952-02-19	1952-02-19	Chlorophyll dentifrice compositions

Publications (1)

Publication Number	Publication Date
US3137632A true US3137632A (en)	1964-06-16

Family

ID=23040165

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
US272525A Expired - Lifetime US3137632A (en)	1952-02-19	1952-02-19	Chlorophyll dentifrice compositions

Country Status (6)

Country	Link
US (1)	US3137632A (hu)
BE (1)	BE516996A (hu)
CH (1)	CH316281A (hu)
DE (1)	DE968516C (hu)
FR (1)	FR1066412A (hu)
GB (1)	GB708232A (hu)

Cited By (36)

* Cited by examiner, † Cited by third party
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US3903252A (en) *	1972-06-08	1975-09-02	Lorvic Corp	Dental disclosing compositions and the method of making and using the same
DE2747092A1 (de) *	1977-10-20	1979-04-26	Wuertt Parfuemerie	Farbstoffhaltige zahnpflegemittel
FR2426458A1 (fr) *	1978-05-25	1979-12-21	Colgate Palmolive Co	Composition de pate dentifrice ayant une texture uniforme
US4264580A (en) *	1979-04-23	1981-04-28	Barberio Giacinto G	Dental cream composition
US4301143A (en) *	1979-12-17	1981-11-17	Colgate-Palmolive Company	Dental cream composition
US4323551A (en) *	1981-02-19	1982-04-06	The Procter & Gamble Company	Mouthwash compositions
US4332791A (en) *	1980-04-29	1982-06-01	Blendax-Werke R. Schneider Gmbh & Co.	Toothpaste active against plaque comprising a copper compound and a silica polishing agent
US4339429A (en) *	1980-04-29	1982-07-13	Blendax-Werke R. Schneider Gmbh & Co.	Toothpaste active against plaque comprising a copper compound and a plastic polishing agent
EP0097476A2 (en) *	1982-06-22	1984-01-04	The Procter & Gamble Company	Oral compositions
US4515772A (en) *	1982-06-22	1985-05-07	The Procter & Gamble Company	Oral compositions
US4590066A (en) *	1982-06-22	1986-05-20	The Procter & Gamble Company	Oral compositions
US4661341A (en) *	1984-10-30	1987-04-28	The Procter & Gamble Company	Oral compositions
US4678662A (en) *	1985-10-09	1987-07-07	Monsanto Company	Pyrophosphate coating process for calcium carbonate dental abrasives
US4684518A (en) *	1982-06-22	1987-08-04	The Procter & Gamble Company	Oral compositions
EP0236290A1 (en) *	1986-03-05	1987-09-09	Monsanto Company	Anticalculus dentifrices
US4806340A (en) *	1985-09-13	1989-02-21	Colgate-Palmolive Company	Anticalculus oral composition
US4885155A (en) *	1982-06-22	1989-12-05	The Procter & Gamble Company	Anticalculus compositions using pyrophosphate salt
US4999184A (en) *	1982-06-22	1991-03-12	The Procter & Gamble Company	Oral compositions
US5000973A (en) *	1989-05-30	1991-03-19	Nabisco Brands, Inc.	Nutritionally-balanced canine biscuits containing an inorganic pyrophosphate
US5000943A (en) *	1989-05-30	1991-03-19	Nabisco Brands, Inc.	Canine biscuits containing an inorganic pyrophosphate
US5011679A (en) *	1989-05-30	1991-04-30	Nabisco Brands, Inc.	Raw hide having a coating containing an inorganic pyrophosphate
US5015485A (en) *	1989-05-30	1991-05-14	Nabisco Brands, Inc.	Dog biscuits having a coating containing an inorganic pyrophosphate
US5094870A (en) *	1989-05-30	1992-03-10	Nabisco Brands, Inc.	Canine biscuits containing an inorganic pyrophosphate
US5114704A (en) *	1989-05-30	1992-05-19	Nabisco Brands, Inc.	Raw hide having a coating containing an inorganic pyrophosphate
WO1993019728A1 (en) *	1992-04-07	1993-10-14	Smithkline Beecham Corporation	Dental formulation
US5294432A (en) *	1991-08-30	1994-03-15	Church & Dwight Co., Inc.	Anticalculus dentifrices
US5294434A (en) *	1991-04-22	1994-03-15	King Ronald M	Aloe vera gel toothpaste
US5514366A (en) *	1993-04-07	1996-05-07	Diamond; Jeffrey H.	Dental and oral preparation for smokers for solubilizing and removing tobacco tars as well as onion and garlic essential oils
US5645841A (en) *	1995-06-05	1997-07-08	Whitehill Oral Technologies, Inc.	Ultramulsion based oral care rinse compositions
US5651959A (en) *	1995-06-05	1997-07-29	Whitehill Oral Technologies, Inc.	Ultramulsion based oral care compositions
US5665374A (en) *	1995-06-05	1997-09-09	Whitehill Oral Technologies, Inc.	Ultramulsion containing interdental delivery devices
US6086372A (en) *	1997-06-04	2000-07-11	Block Drug Company, Inc.	Dental and oral preparation
US20070110681A1 (en) *	2001-12-04	2007-05-17	Whitehill Oral Technologies, Inc.	Flavor-stable dental devices
US8715625B1 (en)	2010-05-10	2014-05-06	The Clorox Company	Natural oral care compositions
WO2016116950A3 (en) *	2015-01-19	2016-10-13	Chitra Vasant Savangikar	Chlorophyll composition
US20220132856A1 (en) *	2019-02-15	2022-05-05	Suncor Energy Inc.	Photosensitizer and chelating agent combinations for use as insecticides

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NL202309A (hu) *	1954-11-24
NL7407759A (hu) *	1973-06-13	1974-12-17
US4075317A (en) *	1974-04-29	1978-02-21	Colgate-Palmolive Company	Dental cream composition
US4046872A (en) *	1974-04-29	1977-09-06	Colgate Palmolive Company	Dental cream
US4122164A (en) *	1975-10-02	1978-10-24	Colgate-Palmolive Company	Dental cream composition
DE3504178A1 (de) *	1985-02-07	1986-08-14	Blendax Werke Schneider Co	Zahnpasta
MX369835B (es) *	2014-05-15	2019-11-21	Procter & Gamble	Composiciones para el cuidado bucal que tienen frescura mejorada.

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GB490384A (en) *	1936-02-15	1938-08-15	Ig Farbenindustrie Ag	Tooth cleansing agents
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0
- BE BE516996D patent/BE516996A/xx unknown
1952
- 1952-02-19 US US272525A patent/US3137632A/en not_active Expired - Lifetime
- 1952-11-07 GB GB28159/52A patent/GB708232A/en not_active Expired
- 1952-11-10 FR FR1066412D patent/FR1066412A/fr not_active Expired
- 1952-11-14 CH CH316281D patent/CH316281A/de unknown
1953
- 1953-01-08 DE DEC6922A patent/DE968516C/de not_active Expired

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DE665707C (de) *	1934-01-19	1938-10-01	Reinhold Grueter Dr	Verfahren zur Herstellung haltbarer Zubereitungen aus Chlorophyll oder chlorophyllhaltigen Stoffen und Mononatriumphosphat
GB444276A (en) *	1935-04-08	1936-03-18	Paul Reinhold Grueter	An improved process for the manufacture of medicinal preparations containing chlorophyll or chlorophylline
GB490384A (en) *	1936-02-15	1938-08-15	Ig Farbenindustrie Ag	Tooth cleansing agents
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GB601801A (en) *	1945-12-03	1948-05-12	Lakeland Foundation	Improvements relating to oral cleansing preparations and methods of making the same
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Cited By (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3903252A (en) *	1972-06-08	1975-09-02	Lorvic Corp	Dental disclosing compositions and the method of making and using the same
DE2747092A1 (de) *	1977-10-20	1979-04-26	Wuertt Parfuemerie	Farbstoffhaltige zahnpflegemittel
US4223003A (en) *	1977-10-20	1980-09-16	Wurttembergische Parfumerie-Fabrik Gmbh	Paste and powder dentifrices
FR2426458A1 (fr) *	1978-05-25	1979-12-21	Colgate Palmolive Co	Composition de pate dentifrice ayant une texture uniforme
US4264580A (en) *	1979-04-23	1981-04-28	Barberio Giacinto G	Dental cream composition
US4301143A (en) *	1979-12-17	1981-11-17	Colgate-Palmolive Company	Dental cream composition
US4332791A (en) *	1980-04-29	1982-06-01	Blendax-Werke R. Schneider Gmbh & Co.	Toothpaste active against plaque comprising a copper compound and a silica polishing agent
US4339429A (en) *	1980-04-29	1982-07-13	Blendax-Werke R. Schneider Gmbh & Co.	Toothpaste active against plaque comprising a copper compound and a plastic polishing agent
US4323551A (en) *	1981-02-19	1982-04-06	The Procter & Gamble Company	Mouthwash compositions
US4885155A (en) *	1982-06-22	1989-12-05	The Procter & Gamble Company	Anticalculus compositions using pyrophosphate salt
EP0297211A3 (en) *	1982-06-22	1989-01-11	The Procter & Gamble Company	Oral compositions
EP0097476A3 (en) *	1982-06-22	1985-05-29	The Procter & Gamble Company	Oral compositions
US4590066A (en) *	1982-06-22	1986-05-20	The Procter & Gamble Company	Oral compositions
US4515772A (en) *	1982-06-22	1985-05-07	The Procter & Gamble Company	Oral compositions
US4999184A (en) *	1982-06-22	1991-03-12	The Procter & Gamble Company	Oral compositions
US4684518A (en) *	1982-06-22	1987-08-04	The Procter & Gamble Company	Oral compositions
EP0395117A2 (en) *	1982-06-22	1990-10-31	The Procter & Gamble Company	Oral treatment and manufacture of an oral composition
EP0297213A2 (en) *	1982-06-22	1989-01-04	The Procter & Gamble Company	Oral treatment and use of an oral composition
EP0297212A2 (en) *	1982-06-22	1989-01-04	The Procter & Gamble Company	Oral compositions
EP0297211A2 (en) *	1982-06-22	1989-01-04	The Procter & Gamble Company	Oral compositions
EP0297213A3 (en) *	1982-06-22	1989-01-11	The Procter & Gamble Company	Oral treatment and manufacture of an oral composition
EP0297212A3 (en) *	1982-06-22	1989-01-11	The Procter & Gamble Company	Oral compositions
EP0395117A3 (en) *	1982-06-22	1993-07-28	The Procter & Gamble Company	Oral treatment and manufacture of an oral composition
EP0345821A1 (en) *	1982-06-22	1989-12-13	The Procter & Gamble Company	Oral compositions
EP0097476A2 (en) *	1982-06-22	1984-01-04	The Procter & Gamble Company	Oral compositions
US4661341A (en) *	1984-10-30	1987-04-28	The Procter & Gamble Company	Oral compositions
US4806340A (en) *	1985-09-13	1989-02-21	Colgate-Palmolive Company	Anticalculus oral composition
US4678662A (en) *	1985-10-09	1987-07-07	Monsanto Company	Pyrophosphate coating process for calcium carbonate dental abrasives
EP0236290A1 (en) *	1986-03-05	1987-09-09	Monsanto Company	Anticalculus dentifrices
US5000973A (en) *	1989-05-30	1991-03-19	Nabisco Brands, Inc.	Nutritionally-balanced canine biscuits containing an inorganic pyrophosphate
US5011679A (en) *	1989-05-30	1991-04-30	Nabisco Brands, Inc.	Raw hide having a coating containing an inorganic pyrophosphate
US5015485A (en) *	1989-05-30	1991-05-14	Nabisco Brands, Inc.	Dog biscuits having a coating containing an inorganic pyrophosphate
US5094870A (en) *	1989-05-30	1992-03-10	Nabisco Brands, Inc.	Canine biscuits containing an inorganic pyrophosphate
US5114704A (en) *	1989-05-30	1992-05-19	Nabisco Brands, Inc.	Raw hide having a coating containing an inorganic pyrophosphate
US5000943A (en) *	1989-05-30	1991-03-19	Nabisco Brands, Inc.	Canine biscuits containing an inorganic pyrophosphate
US5294434A (en) *	1991-04-22	1994-03-15	King Ronald M	Aloe vera gel toothpaste
US5294432A (en) *	1991-08-30	1994-03-15	Church & Dwight Co., Inc.	Anticalculus dentifrices
WO1993019728A1 (en) *	1992-04-07	1993-10-14	Smithkline Beecham Corporation	Dental formulation
US5514366A (en) *	1993-04-07	1996-05-07	Diamond; Jeffrey H.	Dental and oral preparation for smokers for solubilizing and removing tobacco tars as well as onion and garlic essential oils
US5662888A (en) *	1993-04-07	1997-09-02	Jeffrey Mitchell Laboratories	Toothpaste for smokers for solubilizing and removing tobacco tars
US5645841A (en) *	1995-06-05	1997-07-08	Whitehill Oral Technologies, Inc.	Ultramulsion based oral care rinse compositions
US5651959A (en) *	1995-06-05	1997-07-29	Whitehill Oral Technologies, Inc.	Ultramulsion based oral care compositions
US5665374A (en) *	1995-06-05	1997-09-09	Whitehill Oral Technologies, Inc.	Ultramulsion containing interdental delivery devices
US6086372A (en) *	1997-06-04	2000-07-11	Block Drug Company, Inc.	Dental and oral preparation
US20070110681A1 (en) *	2001-12-04	2007-05-17	Whitehill Oral Technologies, Inc.	Flavor-stable dental devices
US8715625B1 (en)	2010-05-10	2014-05-06	The Clorox Company	Natural oral care compositions
WO2016116950A3 (en) *	2015-01-19	2016-10-13	Chitra Vasant Savangikar	Chlorophyll composition
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Also Published As

Publication number	Publication date
GB708232A (en)	1954-04-28
FR1066412A (fr)	1954-06-04
CH316281A (de)	1956-09-30
DE968516C (de)	1958-02-27
BE516996A (hu)

Publication	Publication Date	Title
US3137632A (en)	1964-06-16	Chlorophyll dentifrice compositions
US2941926A (en)	1960-06-21	Chlorophyll dental powder
US3227617A (en)	1966-01-04	Fluoride dentifrice composition
US3634585A (en)	1972-01-11	Dentifrice preparation
JPS5826814A (ja)	1983-02-17	改良された可溶性弗化物有効性を有する歯磨剤
JPH059404B2 (hu)	1993-02-04
US3885028A (en)	1975-05-20	Fluoride-containing toothpaste
US2773801A (en)	1956-12-11	Dentifrice compositions comprising a normally-solid water soluble condensation product of ethylene glycol and polypropylene glycol
US4391798A (en)	1983-07-05	Non-irritating dentifrice
US5932192A (en)	1999-08-03	Lower astringent two component stannous and potassium salt containing dentifrice
WO1991015190A1 (en)	1991-10-17	A powder composition for forming a mouthwash
JPS59205308A (ja)	1984-11-20	歯および口腔の保護製剤
JPS5927323B2 (ja)	1984-07-05	歯みがき組成物
CA1148088A (en)	1983-06-14	Dental cream compositions containing a binary fluorine-providing system and dicalcium phosphate
US4193988A (en)	1980-03-18	Oral hygiene compositions
US4411885A (en)	1983-10-25	Vitamin E oil based dentifrice
US5855871A (en)	1999-01-05	Effervescent two component bicarbonate and acid containing dentifrice
US3511791A (en)	1970-05-12	Denture adherent preparation
US11986551B2 (en)	2024-05-21	Sedative laced toothpaste
US3699220A (en)	1972-10-17	Dentifrice
US3804946A (en)	1974-04-16	Dentifrices containing crystalline silica
US4436720A (en)	1984-03-13	Granulated treatment-and-prophylactic dental preparation possessing anticarious effect
KR880001902B1 (ko)	1988-09-30	치약 조성물
US3894147A (en)	1975-07-08	Method and composition for inhibiting calculus
EP0020617B1 (en)	1982-09-22	Dentifrice