US3044939A - Copper gluconate oral deodorant composition - Google Patents
Copper gluconate oral deodorant composition Download PDFInfo
- Publication number
- US3044939A US3044939A US795612A US79561259A US3044939A US 3044939 A US3044939 A US 3044939A US 795612 A US795612 A US 795612A US 79561259 A US79561259 A US 79561259A US 3044939 A US3044939 A US 3044939A
- Authority
- US
- United States
- Prior art keywords
- copper gluconate
- copper
- deodorant
- deodorant composition
- gluconate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 title claims description 25
- 229940108925 copper gluconate Drugs 0.000 title claims description 25
- 239000002781 deodorant agent Substances 0.000 title claims description 19
- 239000000203 mixture Substances 0.000 title description 12
- 239000012530 fluid Substances 0.000 claims description 3
- 210000000214 mouth Anatomy 0.000 claims description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 1
- 229940050410 gluconate Drugs 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 9
- 229910052802 copper Inorganic materials 0.000 description 9
- 239000010949 copper Substances 0.000 description 9
- 125000005456 glyceride group Chemical group 0.000 description 7
- 239000000843 powder Substances 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 239000000551 dentifrice Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000000606 toothpaste Substances 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000002324 mouth wash Substances 0.000 description 3
- 229940051866 mouthwash Drugs 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 229920001412 Chicle Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical class [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- 240000001794 Manilkara zapota Species 0.000 description 1
- 235000011339 Manilkara zapota Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
Definitions
- This invention rel-ates -to deodorant compositions containing copper gluconate as the effective deodorant, and has for its object to provide a deodorant composition having as its effective ingredient copper gluconate.
- copper gluconate is incorporated in oral medium. In its preferred use it is incorporated in mouth wash, toothpaste, tooth powder, or any suitable dentifrice.
- Our novel deodorant composition exhibits useful deodorant properties over a Wide range of concentrations of the copper gluconate.
- a glyceride fat or oil of small particle size i.e., up to 5 microns.
- a glyceride may provide additive deodorant effects in respect of the degree and the type of deodorant action produced.
- the glyceride is preferably incorporated into the composition in the form of an emulsion.
- the carrier composition of our invention otherwise will contain the ingredients usual for such compositions.
- deodorant compositions of our invention illustrate the novel products that may be obtained therefrom.
- ingredient glyceride is listed, this is any suitable glyceride fat or oil having a particle size up to 5 microns, the weight being on a dry fat basis.
- Example 1 A month wash deodorant having the following composition was prepared:
- the dose range for the copper gluconate is 0.075-0.45 mg.
- Example 3 A tooth powder deodorant having the following .corn-v position was prepared:
- the dose range for. the copper gluconate is 0.075-0.45 mg.
- the dose range for the copper gluconate is 0.075-0.45 mg.
- Copper gluconate has been found to contain about 11 percent of copper. Stone, Drug & Cosmetic Laboratory (August 1950, p. 270). A month wash dosage of 20 cc. incorporating 0.45 mg. of copper gluconate will contain less than 0.05 mg. of copper. Thus if the said dosage is from a bottle of fluid mouth wash of six ounces, the
- a deodorant for the oral cavity comprising copper gluconate and a non-reactive fluid carrier therefor, the amount of the copper gluconate by weight being from about 0.075 mg. to 0.45 mg. relative to a dosage unit of said deodorant of about 20.0 cc.
- a toothpaste deodorant comprising copper gluconate and a non-reactive carrier therefor, the amount of the copper gluconate by weight being from about 0.075 mg. to about 0.45 mg. relative to a dosage unit of said toothpaste of about 1.0 gm.
- a tooth powder deodorant comprising copper glu- 3,044,939 j l ted July 17, 1962 conate and a non-reactive carrier therefor, the amount of the copper gluconate by Weight being from about 0.075 mg. to about 0.45 mg. relative to a dosage unit of said tooth powder of 0.6 gm.
- a liquid dentifrice deodorant comprising copper gluconate and a non-reactive carrier therefor, the amount of the copper gluconate by Weight being from about 0.075 mg. to about 0.45 mg. relative to a dosage unit of said liquid dentifrice of 0.5 cc.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Description
United States Patent 01 3,044,939 COPPER GLUCONATE ORAL DEODORANT COMPOSITION James J. Scanlan, Hillsdale, NJ., and JosephW. E. Hart risson, Lansdowne, Pa., assignors to American Chicle Company, Long Island City, N.Y., a corporation of New Jersey No Drawing. Filed Feb. 26, 1959, Ser. No. 795,612 4 Claims. (Cl. 167-93) This application is a continuation in part of our application filed July 17, 1956, Serial No. 598,241, now US. Patent No. 2,894,876, with a higher top ratio of copper gluconate than in the examples of said application.
This invention rel-ates -to deodorant compositions containing copper gluconate as the effective deodorant, and has for its object to provide a deodorant composition having as its effective ingredient copper gluconate.
According to our invention copper gluconate is incorporated in oral medium. In its preferred use it is incorporated in mouth wash, toothpaste, tooth powder, or any suitable dentifrice.
Our novel deodorant composition exhibits useful deodorant properties over a Wide range of concentrations of the copper gluconate. We prefer to incorporate an amount of copper gluconate which will provide in normal use an average dose of from about 0.075 mg. to about 0.5 mg.
We prefer to use in combination with the copper gluconate a glyceride fat or oil of small particle size (i.e., up to 5 microns). Such a glyceride may provide additive deodorant effects in respect of the degree and the type of deodorant action produced. The glyceride is preferably incorporated into the composition in the form of an emulsion. The carrier composition of our invention otherwise will contain the ingredients usual for such compositions.
The following examples of deodorant compositions of our invention illustrate the novel products that may be obtained therefrom. Where the ingredient glyceride is listed, this is any suitable glyceride fat or oil having a particle size up to 5 microns, the weight being on a dry fat basis.
Example 1 A month wash deodorant having the following composition was prepared:
Boric acid gms 2.5 Benzoic acid ms 0.1 Glycerine gms 2.0 SD. alcohol cc 25.0 Copper gluconate mg 0375-222 Glyceride Q gm 0.031
Distilled water, q.s. 100.0 cc.
On the basis of 20.0 cc. of mouth wash for an average dose, the dose range for the copper gluconate is 0.075-0.45 mg.
Distilled water, q.s. 100 gms.
On the basis of 1.0 gm. of tooth paste for an average dose, the dose range for the copper gluconate is 0.075-0.45 mg. Example 3 A tooth powder deodorant having the following .corn-v position was prepared:
Calcium carbonate (flow rate 27) gms 50.0 Calcium carbonate (flow rate 15) gms 45.0 Powdered castile soap gms 4.9 Soluble saccharin gms 0.1 Copper gluconate mg 12.5-75.0 Glyceride gms 1.0
On the basis of 0.6 gram of tooth powder for an average dose, the dose range for. the copper gluconate, is 0.075-0.45 mg.
Distilled water, q.s. 100.0 cc.
On the basis of 0.5 cc. of dentifrice for an average dose, the dose range for the copper gluconate is 0.075-0.45 mg. When the various compositions of Examples 1-2 were employed by human subjects in the usual manner for each type of composition, a substantial effect was obtained.
Copper gluconate has been found to contain about 11 percent of copper. Stone, Drug & Cosmetic Laboratory (August 1950, p. 270). A month wash dosage of 20 cc. incorporating 0.45 mg. of copper gluconate will contain less than 0.05 mg. of copper. Thus if the said dosage is from a bottle of fluid mouth wash of six ounces, the
entire copper content of the bottle would be less than one half milligram, and a twelve ounce bottle would be short of one milligram. The intake of one mg. of copper is safe, nontoxic, and may be increased in substantial degree without danger. Drummond, in Analyst 50, p. 48 (1925), reported that 10 mg. copper per kg. of food, fed daily to guinea pigs for seventy-two days, had no effect. Kiyooka, in Inst. Domestic Sci., 18, p. 413 (1914) reported that up to 76 mg. daily to man is without effect. It has been established that free copper is absorbed in the intestinal tract from food and is normally supplied in amount above 2 mg. daily (Jones et al., J. Lab. Clin. Med. 1947, 32, 387; US. Dispensatory, 25 ed., p. 363). It has been used with ferrous salts, in vitamin-mineral preparations. Sollman, A Manual of Pharmacology, p. 1113, points out that US. Food Administration set up 30 mg. copper per kg. of food as the permissible ,limit of extraneous copper.
Although the present invention has been described with reference to particular embodiments thereof, it extends to other similar embodiments.
Having fully described ourinvention, what we now claim and desire to secure by Letters Patent is as follows:
1. A deodorant for the oral cavity comprising copper gluconate and a non-reactive fluid carrier therefor, the amount of the copper gluconate by weight being from about 0.075 mg. to 0.45 mg. relative to a dosage unit of said deodorant of about 20.0 cc.
2. A toothpaste deodorant comprising copper gluconate and a non-reactive carrier therefor, the amount of the copper gluconate by weight being from about 0.075 mg. to about 0.45 mg. relative to a dosage unit of said toothpaste of about 1.0 gm.
3. A tooth powder deodorant comprising copper glu- 3,044,939 j l ted July 17, 1962 conate and a non-reactive carrier therefor, the amount of the copper gluconate by Weight being from about 0.075 mg. to about 0.45 mg. relative to a dosage unit of said tooth powder of 0.6 gm.
4. A liquid dentifrice deodorant comprising copper gluconate and a non-reactive carrier therefor, the amount of the copper gluconate by Weight being from about 0.075 mg. to about 0.45 mg. relative to a dosage unit of said liquid dentifrice of 0.5 cc.
References Cited in the file of this patent UNITED STATES PATENTS 2,762,822 Vagenius Sept. 11, 1956 2,894,876 Scanlan et a1. July 14, 1959 2,922,747 Scanlan Jan. 26, 1960 OTHER REFERENCES Stone: Drug and Cosmetic Industry, 67:2, August 1950, pp. 192, 193, 266-71, 273-4.
Claims (1)
1. A DEODORANT FOR THE ORAL CAVITY COMPRISING COPPER GLUCONATE AND A NON-REACTIVE FLUID CARRIER THEREFOR, THE AMOUNT OF THE COPEPR GLUCONATE BY WEIGHT BEING FROM ABOUT 0.075 MG. TO 0.45 MG. RELATIVE TO A DOSAGE UNIT OF SAID DEODORANT OF ABOUT 20.0 CC.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US795612A US3044939A (en) | 1959-02-26 | 1959-02-26 | Copper gluconate oral deodorant composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US795612A US3044939A (en) | 1959-02-26 | 1959-02-26 | Copper gluconate oral deodorant composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3044939A true US3044939A (en) | 1962-07-17 |
Family
ID=25166000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US795612A Expired - Lifetime US3044939A (en) | 1959-02-26 | 1959-02-26 | Copper gluconate oral deodorant composition |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US3044939A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3699221A (en) * | 1965-02-23 | 1972-10-17 | Murray L Schole | Dental preparations |
| US3972996A (en) * | 1975-06-09 | 1976-08-03 | Warner-Lambert Company | Deodorant compositions containing trans-1,4-diphenyl-2-butene-1,4-dione |
| EP0038868A1 (en) * | 1980-04-29 | 1981-11-04 | Blendax-Werke R. Schneider GmbH & Co. | Toothpaste |
| EP0038867A1 (en) * | 1980-04-29 | 1981-11-04 | Blendax-Werke R. Schneider GmbH & Co. | Toothpaste |
| FR2593064A1 (en) * | 1986-01-22 | 1987-07-24 | Colgate Palmolive Co | STABILIZED DENTAL CREAM COMPRISING GLYCERIN, SORBITOL AND VEGETABLE OIL. |
| US5211940A (en) * | 1991-06-21 | 1993-05-18 | Lion Corporation | Transparent liquid oral composition |
| US5286479A (en) * | 1991-12-10 | 1994-02-15 | The Dow Chemical Company | Oral compositions for suppressing mouth odors |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2762822A (en) * | 1954-03-04 | 1956-09-11 | Harold N Vagenius | Copper nitrogenous organic compound |
| US2894876A (en) * | 1956-07-17 | 1959-07-14 | American Chicle Co | Deodorant composition |
| US2922747A (en) * | 1957-06-14 | 1960-01-26 | American Chicle Co | Deodorant composition |
-
1959
- 1959-02-26 US US795612A patent/US3044939A/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2762822A (en) * | 1954-03-04 | 1956-09-11 | Harold N Vagenius | Copper nitrogenous organic compound |
| US2894876A (en) * | 1956-07-17 | 1959-07-14 | American Chicle Co | Deodorant composition |
| US2922747A (en) * | 1957-06-14 | 1960-01-26 | American Chicle Co | Deodorant composition |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3699221A (en) * | 1965-02-23 | 1972-10-17 | Murray L Schole | Dental preparations |
| US3972996A (en) * | 1975-06-09 | 1976-08-03 | Warner-Lambert Company | Deodorant compositions containing trans-1,4-diphenyl-2-butene-1,4-dione |
| EP0038868A1 (en) * | 1980-04-29 | 1981-11-04 | Blendax-Werke R. Schneider GmbH & Co. | Toothpaste |
| EP0038867A1 (en) * | 1980-04-29 | 1981-11-04 | Blendax-Werke R. Schneider GmbH & Co. | Toothpaste |
| JPS56169619A (en) * | 1980-04-29 | 1981-12-26 | Blendax Werke Schneider Co | Tooth paste composition |
| US4332791A (en) * | 1980-04-29 | 1982-06-01 | Blendax-Werke R. Schneider Gmbh & Co. | Toothpaste active against plaque comprising a copper compound and a silica polishing agent |
| US4339429A (en) * | 1980-04-29 | 1982-07-13 | Blendax-Werke R. Schneider Gmbh & Co. | Toothpaste active against plaque comprising a copper compound and a plastic polishing agent |
| JPS6324487B2 (en) * | 1980-04-29 | 1988-05-20 | Burendatsukusu Beruke Eru Shunaidaa Gmbh Unto Co | |
| FR2593064A1 (en) * | 1986-01-22 | 1987-07-24 | Colgate Palmolive Co | STABILIZED DENTAL CREAM COMPRISING GLYCERIN, SORBITOL AND VEGETABLE OIL. |
| BE1000635A4 (en) * | 1986-01-22 | 1989-02-28 | Colgate Palmolive Co | STABILIZED DENTAL CREAM COMPRISING GLYCERIN, SORBITOL AND VEGETABLE OIL. |
| US5211940A (en) * | 1991-06-21 | 1993-05-18 | Lion Corporation | Transparent liquid oral composition |
| US5286479A (en) * | 1991-12-10 | 1994-02-15 | The Dow Chemical Company | Oral compositions for suppressing mouth odors |
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