US3025991A - Bottle stopper - Google Patents
Bottle stopper Download PDFInfo
- Publication number
- US3025991A US3025991A US31086A US3108660A US3025991A US 3025991 A US3025991 A US 3025991A US 31086 A US31086 A US 31086A US 3108660 A US3108660 A US 3108660A US 3025991 A US3025991 A US 3025991A
- Authority
- US
- United States
- Prior art keywords
- stopper
- bottle
- vial
- resilient
- bottle stopper
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
- B65D51/241—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes provided with freeze-drying means
Definitions
- the invention relates to resilient stoppers for use with bottles or vials, which are or may be used for various types of parenteral solutions or the like. It relates particularly to a resilient stopper possessing particular configurations that render it satisfactory for application to bottles or vials either by hand or by automatic stoppering machines.
- An additional object of my invention is to provide a resilient bottle or vial stopper having a membrane which may be readily pierced by a hypodermic needle or the like, when the product is to be administered and which will re-seal subsequently to prevent contamination of that portion of the product remaining in the bottle or vial.
- a resilient stopper with a substantially cylindrical plug or body portion of a larger diameter than the neck opening in the bottle or "ial with which the stopper will be used; with a flange or head extending from the outer end of the stopper to afford a surface for effectively sealing the bottle or vial by the application of an aluminum seal or other standard type of seal.
- Such seals are well known to those skilled in the art.
- Another important object of the invention is to provide a stopper with one or more ribs on the plug portion thereof, which ribs may be uniformly or irregularly spaced and of the same or lesser diameter and thickness. Such ribs may be used as stops to control the depth of insertion of the stopper into the bottle or vial, thereby controlling the size of the opening afforded to permit the flow of gases in processing or the speed of evacuation prior to full insertion of the stopper to close the bottle or vial.
- Further object of the invention is to provide a resilient, readily compressible stopper for bottles or vials with an opening in one side of the cylindrical plug portion which, when partially inserted, will permit the free flow of air into or from the container.
- FIG. 1 is a perspective view of a stopper embodying my invention in one form
- FIG. 2 is a View fragmentarily showing a bottle or vial in section with a stopper of FIG. 1 in place and in elevation;
- FIG. 3 is a section taken as indicated by the angled arrows III-III in FIG. 2 with a stopper partly withdrawn;
- FIG. 4 is a cross section taken as indicated by the angled arrows IV-IV in FIG. 3;
- FIG. 5 is a perspective View of a modified form of the stopper.
- FIG. 6 is a view similar to FIG. 3 showing the modified stopper partially inserted into the bottle or vial.
- the stopper of my invention in the form there illustrated is comprehensively designated by the numeral 10. It is to be understood that the stopper is molded or otherwise fashioned in practice, of rubber or other suitably resilient material. As shown, the stopper 10 has a flat head 11 and a generally cylindrical plug portion 12 of smaller diameter pendent from said head, said plug portion having a relatively narrow radial slot 13 with flared or splayed sides extending vertically from the bottom of the plug portion to said head, and horizontally to an appropriate distance into one side of said plug portion but sufficiently short of the other side to avoid weakening the opposite wall area.
- the body portion 12 of the stopper is provided with an uneven number (in this instance 3) of spaced circumferential beads or ridges 15 and its bottom edge is rounded or beveled ofi as at 16.
- the diameters of the body portion 12 of the stopper and of the ridges 15 are somewhat larger than the internal diameter of the neck N of the bottle B, however, so as to engage tightly into the neck with a tight compression fit, and with the flange projection of the head 11 bearing fluid seal tight against the month top of the bottle or vial.
- the stopper 15 is partially inserted for exposure of the portion of the side vent slot 13 above the bottle mouth with one or the other of the circumferential ridges 15 stopped against the top of the bottle mouth as instanced in FIG. 3.
- the mid-ridge of the group 15 is used to limit the extent to which the stopper is inserted during lyophilizing, or freezing, or drying of pharmaceutical biologicals or other products with which the bottle or vial is filled. It is to be noted that the thickness of the membrane between the top of the cap and the hollow 13 of the plug portion 12 is such that it is easily penetrated by a hypodermic needle when some or all of the contents of the bottle or vial are to be withdrawn. It is to be further noted that the flaring or splaying of the sides of slot is advantageous in that it does not impede outward flow of the gases or vapors from the bottle or vial.
- Modified stopper illustrated in FIGS. 5 and 6 differs from the first described form only in that the mid-ridge 15a on the plug is thicker and larger in diameter than the other ridges. Therefore, in order to obviate the necessity for repetitive description, all of the other elements in the modification having their counterparts in the first described embodiment have been identified by the same reference numerals previously used with addition, however, in each instance of the letter a for convenience of more ready distinction.
- a bottle stopper of resilient material having a flat circular head, and a coaxial pendent cylindrical plug extension adapted to engage into the mouth of the bottle with a compression fit, said extension having a radial slot which flares outwardly from the center of the stopper and terminates short of the head, and being provided with at least three outwardly projecting circumferential stop ribs for selective engagement with the top of the bottle mouth to determine different positions of insertion for the stopper.
- a bottle stopper characterized as in claim 1, in which the ribs are three in number and of which ribs the center one of the group is wider and projects outwardly to a greater extent than the others.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Closures For Containers (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
March 1962 H. GILL-ON 3,025,991
BOTTLE STOPPER Filed May 23, 1960 FICr'zl INVEIYTOR. James 19? 67/1017,
BY 62.]: Q!
3,025,991 BOTTLE STOPPER James H. Gillon, Bala Cynwyd, Pa., assignor to Carron Products Co., Philadelphia, Pa., a firm Filed May 23, 1960, Ser. No. 31,086 2 Claims. (Cl. 215-56) The invention relates to resilient stoppers for use with bottles or vials, which are or may be used for various types of parenteral solutions or the like. It relates particularly to a resilient stopper possessing particular configurations that render it satisfactory for application to bottles or vials either by hand or by automatic stoppering machines.
It is an object of my invention to provide a resilient stopper especially suitable for facilitating evacuation of gases or vapors from bottles or vials developed during the lyophilizing, or freeze-drying of pharmaceutical, biological or other products produced by this method of manufacture.
An additional object of my invention is to provide a resilient bottle or vial stopper having a membrane which may be readily pierced by a hypodermic needle or the like, when the product is to be administered and which will re-seal subsequently to prevent contamination of that portion of the product remaining in the bottle or vial.
Other objects of the invention are to provide a resilient stopper with a substantially cylindrical plug or body portion of a larger diameter than the neck opening in the bottle or "ial with which the stopper will be used; with a flange or head extending from the outer end of the stopper to afford a surface for effectively sealing the bottle or vial by the application of an aluminum seal or other standard type of seal. Such seals are well known to those skilled in the art.
Another important object of the invention is to provide a stopper with one or more ribs on the plug portion thereof, which ribs may be uniformly or irregularly spaced and of the same or lesser diameter and thickness. Such ribs may be used as stops to control the depth of insertion of the stopper into the bottle or vial, thereby controlling the size of the opening afforded to permit the flow of gases in processing or the speed of evacuation prior to full insertion of the stopper to close the bottle or vial.
Further object of the invention is to provide a resilient, readily compressible stopper for bottles or vials with an opening in one side of the cylindrical plug portion which, when partially inserted, will permit the free flow of air into or from the container.
Other objects and attendant advantages will appear from the following detailed description of the attached drawings, wherein:
FIG. 1 is a perspective view of a stopper embodying my invention in one form;
FIG. 2 is a View fragmentarily showing a bottle or vial in section with a stopper of FIG. 1 in place and in elevation;
FIG. 3 is a section taken as indicated by the angled arrows III-III in FIG. 2 with a stopper partly withdrawn;
FIG. 4 is a cross section taken as indicated by the angled arrows IV-IV in FIG. 3;
FIG. 5 is a perspective View of a modified form of the stopper; and
FIG. 6 is a view similar to FIG. 3 showing the modified stopper partially inserted into the bottle or vial.
With more detailed reference first to FIGS. 1-4 of these drawings, the stopper of my invention in the form there illustrated is comprehensively designated by the numeral 10. It is to be understood that the stopper is molded or otherwise fashioned in practice, of rubber or other suitably resilient material. As shown, the stopper 10 has a flat head 11 and a generally cylindrical plug portion 12 of smaller diameter pendent from said head, said plug portion having a relatively narrow radial slot 13 with flared or splayed sides extending vertically from the bottom of the plug portion to said head, and horizontally to an appropriate distance into one side of said plug portion but sufficiently short of the other side to avoid weakening the opposite wall area. As shown further, the body portion 12 of the stopper is provided with an uneven number (in this instance 3) of spaced circumferential beads or ridges 15 and its bottom edge is rounded or beveled ofi as at 16. The diameters of the body portion 12 of the stopper and of the ridges 15 are somewhat larger than the internal diameter of the neck N of the bottle B, however, so as to engage tightly into the neck with a tight compression fit, and with the flange projection of the head 11 bearing fluid seal tight against the month top of the bottle or vial. For release of air or gases from the bottle, the stopper 15 is partially inserted for exposure of the portion of the side vent slot 13 above the bottle mouth with one or the other of the circumferential ridges 15 stopped against the top of the bottle mouth as instanced in FIG. 3. Ordinarily, the mid-ridge of the group 15 is used to limit the extent to which the stopper is inserted during lyophilizing, or freezing, or drying of pharmaceutical biologicals or other products with which the bottle or vial is filled. It is to be noted that the thickness of the membrane between the top of the cap and the hollow 13 of the plug portion 12 is such that it is easily penetrated by a hypodermic needle when some or all of the contents of the bottle or vial are to be withdrawn. It is to be further noted that the flaring or splaying of the sides of slot is advantageous in that it does not impede outward flow of the gases or vapors from the bottle or vial.
Modified stopper illustrated in FIGS. 5 and 6 differs from the first described form only in that the mid-ridge 15a on the plug is thicker and larger in diameter than the other ridges. Therefore, in order to obviate the necessity for repetitive description, all of the other elements in the modification having their counterparts in the first described embodiment have been identified by the same reference numerals previously used with addition, however, in each instance of the letter a for convenience of more ready distinction.
Having thus described my invention, I claim:
1. As a new product of manufacture, a bottle stopper of resilient material having a flat circular head, and a coaxial pendent cylindrical plug extension adapted to engage into the mouth of the bottle with a compression fit, said extension having a radial slot which flares outwardly from the center of the stopper and terminates short of the head, and being provided with at least three outwardly projecting circumferential stop ribs for selective engagement with the top of the bottle mouth to determine different positions of insertion for the stopper.
2. A bottle stopper characterized as in claim 1, in which the ribs are three in number and of which ribs the center one of the group is wider and projects outwardly to a greater extent than the others.
References Cited in the file of this patent UNITED STATES PATENTS 2,927,709 Hoffman et a1. Mar. 8, 1960 2,940,627 Schultz June 14, 1960 FOREIGN PATENTS 729,903 Great Britain May 11, 1955 1,200,415 France Dec. 21, 1959 UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. 3,025,991 March 20, 1962 I James H. Gillon It is hereby certified that error appears in the above numbered patent requiring correction and that the said Letters Patent should read as corrected below.
In the drawings, line 1, name of inventor, for "L. H. GILLON read J. H. GILLON Signed and sealed this, 17th day of July 1962.
(SEAL) Attest:
ERNEST w. SWIDER DAVID LADD Attesting Officer Commissioner of Patents
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31086A US3025991A (en) | 1960-05-23 | 1960-05-23 | Bottle stopper |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31086A US3025991A (en) | 1960-05-23 | 1960-05-23 | Bottle stopper |
Publications (1)
Publication Number | Publication Date |
---|---|
US3025991A true US3025991A (en) | 1962-03-20 |
Family
ID=21857573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US31086A Expired - Lifetime US3025991A (en) | 1960-05-23 | 1960-05-23 | Bottle stopper |
Country Status (1)
Country | Link |
---|---|
US (1) | US3025991A (en) |
Cited By (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3810469A (en) * | 1972-05-24 | 1974-05-14 | Ampoules Inc | Multiple compartment hypodermic devices |
US3834571A (en) * | 1972-11-20 | 1974-09-10 | Warner Lambert Co | Container closure for lyophilized products |
US3881626A (en) * | 1972-11-20 | 1975-05-06 | Warner Lambert Co | Container closure for lyophilized products |
DE2902081A1 (en) * | 1978-02-08 | 1979-08-09 | Rumpler Jean Jacques | STOPPER FOR DRUG CONTAINER |
US5110004A (en) * | 1989-03-23 | 1992-05-05 | The Procter & Gamble Company | Lid assembly |
US6857755B1 (en) | 2003-09-10 | 2005-02-22 | Buztronics, Inc. | Illuminated bottle cap with epoxy dome |
US20050095284A1 (en) * | 2003-10-31 | 2005-05-05 | Alza Corporation | Osmotic pump with self-retaining, fast-start membrane plug |
US20050173366A1 (en) * | 2004-02-06 | 2005-08-11 | L'oreal | Closure cap and a receptacle fitted with such a cap |
US20060134354A1 (en) * | 2004-12-16 | 2006-06-22 | Walters Jay M | Calibration vial stopper with improved security features |
WO2007020240A1 (en) * | 2005-08-13 | 2007-02-22 | Boehringer Ingelheim International Gmbh | Twin-chamber lyophilization receptacle, method for filling the same, and use thereof |
US20070060875A1 (en) * | 2005-08-13 | 2007-03-15 | Stefan Bassarab | Dual chamber container without by-pass in the cylindrical body |
US20070060876A1 (en) * | 2005-08-13 | 2007-03-15 | Stefan Bassarab | Dual chamber container without by-pass |
US20070129673A1 (en) * | 2005-08-13 | 2007-06-07 | Stefan Bassarab | Dual chamber container and process for its filling up |
US20090001042A1 (en) * | 2007-06-26 | 2009-01-01 | Robert Sever | Container-closure system for use in lyophilization applications |
US20100206836A1 (en) * | 2007-10-18 | 2010-08-19 | Tsuyoshi Koshidaka | Vial rubber-stopper |
WO2012016301A1 (en) * | 2010-08-06 | 2012-02-09 | Hospira Australia Pty Ltd | Vial preparation method and system |
EP2517791A1 (en) * | 2011-04-18 | 2012-10-31 | Vibod GmbH | Sample tube with improved lid |
US9526763B2 (en) | 2005-02-03 | 2016-12-27 | Intarcia Therapeutics Inc. | Solvent/polymer solutions as suspension vehicles |
US9539200B2 (en) | 2005-02-03 | 2017-01-10 | Intarcia Therapeutics Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
US9572889B2 (en) | 2008-02-13 | 2017-02-21 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
US9682127B2 (en) | 2005-02-03 | 2017-06-20 | Intarcia Therapeutics, Inc. | Osmotic delivery device comprising an insulinotropic peptide and uses thereof |
US9724293B2 (en) | 2003-11-17 | 2017-08-08 | Intarcia Therapeutics, Inc. | Methods of manufacturing viscous liquid pharmaceutical formulations |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
US10124534B2 (en) * | 2013-07-18 | 2018-11-13 | Bayerische Motoren Werke Aktiengesellschaft | Adhesive aid and method for adhering components |
USD835506S1 (en) * | 2017-05-24 | 2018-12-11 | Helen Of Troy Limited | Bottle stopper |
USD835783S1 (en) | 2016-06-02 | 2018-12-11 | Intarcia Therapeutics, Inc. | Implant placement guide |
US10159714B2 (en) | 2011-02-16 | 2018-12-25 | Intarcia Therapeutics, Inc. | Compositions, devices and methods of use thereof for the treatment of cancers |
US10231923B2 (en) | 2009-09-28 | 2019-03-19 | Intarcia Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
US20190185228A1 (en) * | 2017-12-20 | 2019-06-20 | Tecan Trading Ag | Closure element with vent opening |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
US10501517B2 (en) | 2016-05-16 | 2019-12-10 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
US10527170B2 (en) | 2006-08-09 | 2020-01-07 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies for use therein |
USD878915S1 (en) * | 2018-09-18 | 2020-03-24 | Midnight Madness Distilling, Llc | Stopper |
US10835580B2 (en) | 2017-01-03 | 2020-11-17 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug |
US20210009320A1 (en) * | 2019-07-09 | 2021-01-14 | A. Raymond Et Cie | Locking top for vessel having a neck |
US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
EP4166232A1 (en) * | 2021-10-15 | 2023-04-19 | Leica Mikrosysteme GmbH | Storage container for storing a sample holder |
USD1009627S1 (en) * | 2021-12-17 | 2024-01-02 | Stasis Preservation LLC | Bottled beverage preservation cap |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB729903A (en) * | 1953-12-11 | 1955-05-11 | Renato Mantovani | Closure for collapsible tubes |
FR1200415A (en) * | 1959-04-03 | 1959-12-21 | Plastic container with axially sliding stopper in a seat between two corresponding extreme positions, one for the closure to be obtained, the other for the position for filling and pouring the contents | |
US2927709A (en) * | 1959-07-07 | 1960-03-08 | Faultless Rubber Co | Bottle stopple |
US2940627A (en) * | 1958-02-25 | 1960-06-14 | Lok Seal Inc | Champagne bottle closure |
-
1960
- 1960-05-23 US US31086A patent/US3025991A/en not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB729903A (en) * | 1953-12-11 | 1955-05-11 | Renato Mantovani | Closure for collapsible tubes |
US2940627A (en) * | 1958-02-25 | 1960-06-14 | Lok Seal Inc | Champagne bottle closure |
FR1200415A (en) * | 1959-04-03 | 1959-12-21 | Plastic container with axially sliding stopper in a seat between two corresponding extreme positions, one for the closure to be obtained, the other for the position for filling and pouring the contents | |
US2927709A (en) * | 1959-07-07 | 1960-03-08 | Faultless Rubber Co | Bottle stopple |
Cited By (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3810469A (en) * | 1972-05-24 | 1974-05-14 | Ampoules Inc | Multiple compartment hypodermic devices |
US3834571A (en) * | 1972-11-20 | 1974-09-10 | Warner Lambert Co | Container closure for lyophilized products |
US3881626A (en) * | 1972-11-20 | 1975-05-06 | Warner Lambert Co | Container closure for lyophilized products |
DE2902081A1 (en) * | 1978-02-08 | 1979-08-09 | Rumpler Jean Jacques | STOPPER FOR DRUG CONTAINER |
US5110004A (en) * | 1989-03-23 | 1992-05-05 | The Procter & Gamble Company | Lid assembly |
US6857755B1 (en) | 2003-09-10 | 2005-02-22 | Buztronics, Inc. | Illuminated bottle cap with epoxy dome |
US20050095284A1 (en) * | 2003-10-31 | 2005-05-05 | Alza Corporation | Osmotic pump with self-retaining, fast-start membrane plug |
US7407499B2 (en) * | 2003-10-31 | 2008-08-05 | Intarcia Therapeutics, Inc. | Osmotic pump with self-retaining, fast-start membrane plug |
US20080269726A1 (en) * | 2003-10-31 | 2008-10-30 | Intarcia Therapeutics, Inc. | Osmotic pump with self-retaining, fast-start membrane plug |
US9724293B2 (en) | 2003-11-17 | 2017-08-08 | Intarcia Therapeutics, Inc. | Methods of manufacturing viscous liquid pharmaceutical formulations |
US20050173366A1 (en) * | 2004-02-06 | 2005-08-11 | L'oreal | Closure cap and a receptacle fitted with such a cap |
US7717281B2 (en) * | 2004-02-06 | 2010-05-18 | L'oreal | Closure cap with a sealing stud having increased deformability and a receptacle fitted with such a cap |
US20060134354A1 (en) * | 2004-12-16 | 2006-06-22 | Walters Jay M | Calibration vial stopper with improved security features |
WO2006066056A2 (en) * | 2004-12-16 | 2006-06-22 | Dade Behring Inc. | Calibration vial stopper with improved security features |
WO2006066056A3 (en) * | 2004-12-16 | 2006-10-19 | Dade Behring Inc | Calibration vial stopper with improved security features |
US9682127B2 (en) | 2005-02-03 | 2017-06-20 | Intarcia Therapeutics, Inc. | Osmotic delivery device comprising an insulinotropic peptide and uses thereof |
US9526763B2 (en) | 2005-02-03 | 2016-12-27 | Intarcia Therapeutics Inc. | Solvent/polymer solutions as suspension vehicles |
US9539200B2 (en) | 2005-02-03 | 2017-01-10 | Intarcia Therapeutics Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
US10363287B2 (en) | 2005-02-03 | 2019-07-30 | Intarcia Therapeutics, Inc. | Method of manufacturing an osmotic delivery device |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
US8002734B2 (en) * | 2005-08-13 | 2011-08-23 | Boehringer Ingelheim International Gmbh | Dual chamber container and process for its filling up |
US20070060877A1 (en) * | 2005-08-13 | 2007-03-15 | Stefan Bassarab | Dual chamber container for lyophilization, process for the filling up and use thereof |
US8096971B2 (en) | 2005-08-13 | 2012-01-17 | Boehringer Ingelheim International Gmbh | Dual chamber container for lyophilization, process for the filling up and use thereof |
US20090182301A1 (en) * | 2005-08-13 | 2009-07-16 | Stefan Bassarab | Dual chamber container without by-pass |
US20070129673A1 (en) * | 2005-08-13 | 2007-06-07 | Stefan Bassarab | Dual chamber container and process for its filling up |
WO2007020240A1 (en) * | 2005-08-13 | 2007-02-22 | Boehringer Ingelheim International Gmbh | Twin-chamber lyophilization receptacle, method for filling the same, and use thereof |
US20070060875A1 (en) * | 2005-08-13 | 2007-03-15 | Stefan Bassarab | Dual chamber container without by-pass in the cylindrical body |
US20070060876A1 (en) * | 2005-08-13 | 2007-03-15 | Stefan Bassarab | Dual chamber container without by-pass |
US10527170B2 (en) | 2006-08-09 | 2020-01-07 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies for use therein |
US20090001042A1 (en) * | 2007-06-26 | 2009-01-01 | Robert Sever | Container-closure system for use in lyophilization applications |
US20100206836A1 (en) * | 2007-10-18 | 2010-08-19 | Tsuyoshi Koshidaka | Vial rubber-stopper |
US10441528B2 (en) | 2008-02-13 | 2019-10-15 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
US9572889B2 (en) | 2008-02-13 | 2017-02-21 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
US10231923B2 (en) | 2009-09-28 | 2019-03-19 | Intarcia Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
US12042557B2 (en) | 2009-09-28 | 2024-07-23 | I2O Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
US10869830B2 (en) | 2009-09-28 | 2020-12-22 | Intarcia Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
AU2011286179B2 (en) * | 2010-08-06 | 2016-05-05 | Hospira Australia Pty Ltd | Vial preparation method and system |
CN103770967A (en) * | 2010-08-06 | 2014-05-07 | 护益仁澳大利亚私人有限公司 | Vial preparation method and system |
US20130205719A1 (en) * | 2010-08-06 | 2013-08-15 | Emma J. Wensley | Vial preparation method and system |
CN103770967B (en) * | 2010-08-06 | 2017-08-15 | 护益仁澳大利亚私人有限公司 | The preparation method and system of bottle |
US10364053B2 (en) * | 2010-08-06 | 2019-07-30 | Hospira Australia Pty Ltd | Vial preparation method and system |
CN103209898A (en) * | 2010-08-06 | 2013-07-17 | 护益仁澳大利亚私人有限公司 | Vial preparation method and system |
WO2012016301A1 (en) * | 2010-08-06 | 2012-02-09 | Hospira Australia Pty Ltd | Vial preparation method and system |
US10159714B2 (en) | 2011-02-16 | 2018-12-25 | Intarcia Therapeutics, Inc. | Compositions, devices and methods of use thereof for the treatment of cancers |
EP2517791A1 (en) * | 2011-04-18 | 2012-10-31 | Vibod GmbH | Sample tube with improved lid |
JP2014534058A (en) * | 2011-10-13 | 2014-12-18 | フィボット ゲーエムベーハー | Sample tube with improved lid |
WO2013053620A1 (en) | 2011-10-13 | 2013-04-18 | Vibod Gmbh | Sample tube with improved lid |
US10124534B2 (en) * | 2013-07-18 | 2018-11-13 | Bayerische Motoren Werke Aktiengesellschaft | Adhesive aid and method for adhering components |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
US10583080B2 (en) | 2014-09-30 | 2020-03-10 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
US11840559B2 (en) | 2016-05-16 | 2023-12-12 | I2O Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
US11214607B2 (en) | 2016-05-16 | 2022-01-04 | Intarcia Therapeutics Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
US10501517B2 (en) | 2016-05-16 | 2019-12-10 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
USD835783S1 (en) | 2016-06-02 | 2018-12-11 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD962433S1 (en) | 2016-06-02 | 2022-08-30 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD912249S1 (en) | 2016-06-02 | 2021-03-02 | Intarcia Therapeutics, Inc. | Implant removal tool |
US11654183B2 (en) | 2017-01-03 | 2023-05-23 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of exenatide and co-administration of a drug |
US10835580B2 (en) | 2017-01-03 | 2020-11-17 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug |
USD835506S1 (en) * | 2017-05-24 | 2018-12-11 | Helen Of Troy Limited | Bottle stopper |
US20190185228A1 (en) * | 2017-12-20 | 2019-06-20 | Tecan Trading Ag | Closure element with vent opening |
USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
USD878915S1 (en) * | 2018-09-18 | 2020-03-24 | Midnight Madness Distilling, Llc | Stopper |
US11738915B2 (en) * | 2019-07-09 | 2023-08-29 | A. Raymond Et Cie | Locking top for vessel having a neck |
US20210009320A1 (en) * | 2019-07-09 | 2021-01-14 | A. Raymond Et Cie | Locking top for vessel having a neck |
EP4166232A1 (en) * | 2021-10-15 | 2023-04-19 | Leica Mikrosysteme GmbH | Storage container for storing a sample holder |
USD1009627S1 (en) * | 2021-12-17 | 2024-01-02 | Stasis Preservation LLC | Bottled beverage preservation cap |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US3025991A (en) | Bottle stopper | |
US5060812A (en) | Medication container stopper which can be punctured by nozzle of a hypodermic syringe | |
US2927709A (en) | Bottle stopple | |
US2848130A (en) | Pressure resistant closures | |
US4089432A (en) | Vial and closure | |
US5224515A (en) | Tube closure | |
US2906423A (en) | Closure puncturable by polyethylene needle | |
US4193402A (en) | Bottle stopper and method of using said stopper | |
US4296786A (en) | Transfer device for use in mixing a primary solution and a secondary or additive substance | |
US3674028A (en) | Multi-mix | |
US3439823A (en) | Container stopper comprising a hollow capsule | |
JP3549907B2 (en) | Elastic plug | |
US4133462A (en) | Container closure | |
US3454178A (en) | Sterile cap for a freeze-drying container and method of freeze-drying materials under sterile conditions | |
US2582721A (en) | Bottle closure | |
US2731053A (en) | Medical containers and their closures | |
US3013687A (en) | Closure for packages of biological products | |
US20180134457A1 (en) | Closing assembly for a bottle, associated bottle and assembly method | |
US2886198A (en) | Bottle stopping device | |
US4202334A (en) | Cap and stopper | |
US3005564A (en) | Laboratory equipment | |
US3770155A (en) | Dually sealable, non-leaking vial for shipping radioactive materials | |
US2718974A (en) | Expansion stopper | |
US3540612A (en) | Bottle cap and bottle combination | |
US3834571A (en) | Container closure for lyophilized products |