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US2157503A - Ampoule syringe - Google Patents

Ampoule syringe Download PDF

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Publication number
US2157503A
US2157503A US73654A US7365436A US2157503A US 2157503 A US2157503 A US 2157503A US 73654 A US73654 A US 73654A US 7365436 A US7365436 A US 7365436A US 2157503 A US2157503 A US 2157503A
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United States
Prior art keywords
ampoule
syringe
closure
cork
seal
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Expired - Lifetime
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US73654A
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Arthur E Smith
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06Ampoules or carpules
    • A61J1/062Carpules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403Ampoule inserted into the ampoule holder
    • A61M2005/2407Ampoule inserted into the ampoule holder from the rear
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2433Ampoule fixed to ampoule holder
    • A61M2005/2437Ampoule fixed to ampoule holder by clamping means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A61M2005/247Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with fixed or steady piercing means, e.g. piercing under movement of ampoule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2477Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means to reduce play of ampoule within ampoule holder, e.g. springs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/344Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets

Definitions

  • This invention relates to syringes.
  • the general object of the invention is to provide an improved syringe which is particularly adapted for use in connection with ampoules.
  • a further object of the invention is to provide an improved ampoule for use in a syringe.
  • An additional object of the invention is to provide a syringe and ampoule wherein novel means is provided for preventing leakage at the front end of the ampoule.
  • Another object of the invention is to provide a novel cork for use in an ampoule.
  • Another object of the invention is to provide novel means for sealing an ampoule.
  • Fig. 1 is a central, sectional View through a 20 syringe and ampoule embodying the features of my invention
  • Fig. 2 is an enlarged, fragmentary, central, sectional, View through the upper end of my improved ampoule showing the cork therein;
  • Fig, 3 is an enlarged, fragmentary, central, sectional view showing the upper end of the ampoule with the cork engaged by the plunger;
  • Fig. 4 is a view similar to Fig. 1 showing a slight modication of my invention
  • Fig. 5 is an enlarged, fragmentary, sectional view showing the front end of the modified syringe
  • Fig. 6 is a view similar to Fig. 1 showing a further modii'lcatiom and Fig. 7 is an enlarged, fragmentary, sectional View showing the lower end of the syringe shown in Fig. 6.
  • the syringe includes a barrel I I having a front member I2 threaded therein.
  • This front member is provided with a threaded front end on which a needle I3 is mounted.
  • the front member is also provided with a closure piercing member or needle I4 which is fixed thereon and which is provided at its inner end I5 with a sharpened portion which projects into a recess in the front member.
  • the outer end of the front member recess is shown as cylindrical as at I6, while the inner portion is rounded as at I1.
  • the barrel Opposite the front member the barrel is provided with a closure I8 which is threaded as at I9 to the barrel and slidably mounted within the closure is a plunger rod 20 having a head 2I on Los Angeles, Calif.
  • a removable ampoule 26 which is preferably made of glass and which is cylindrical in form with the upper end of the ampoule engaged by the skirt 24 on the head 23 of the plunger.
  • the front end of the ampoule is of reduced diameter as at 2'I and on the reduced portion I mount a seal 28 comprising an inner cap which is preferably made of rubber.
  • This cap includes a skirt 29 which tightly engages the end of the ampoule and the skirt is provided with an end portion 30 which is shown as slightly thicker than the skirt and which includes a boss which extends into the ampoule.
  • a cap or covering of thin, exible, transparent material such as Celluloid, collodion, regenerated cellulose such as Cellophane, or other material preferably of a nature so that it shrinks when it dries and thus tightly engages the rubber closure and causes this closure to tightly engage the neck of the ampoule.
  • the covering is shown as extending down onto the neck as at 3
  • This seal consists of two separate media both of which are impervious but are capable of being penetrated by the sharpened end I5 of the needle with the outer member tough and more resistant so that it will in a measure serve as a protection for the rubber member.
  • the rear end of the ampoule is provided with a cork 35 which includes a protuberant head portion 36 and a side wall 31.
  • a cork 35 which includes a protuberant head portion 36 and a side wall 31.
  • an internal boss 38 which terminates short of the end of the side wall.
  • 'Ihe slide wall is provided on its inner surface with a peripheral groove 39 in which a sealing disk 43 which may be made of Celluloid is seated.
  • This disk 40 serves to hold a medicinal preparation shown as a tablet 4I in place in the cork.
  • the tablet 4I is shown as contacting the lower face of the boss 38 and the disk 40.
  • the interior of the ampoule is filled with a suitable vehicle for the medicinal preparation 4I and thus when the steps mentioned have occurred the preparation 4I is discharged into the vehicle in the ampoule and a fresh solution of material is provided.
  • the plunger 20 is forced inwardly thus causing the cork 36 to move within the ampoule and causing the material to pass out through the needle I3.
  • the pressure of the spring 25, together with this forward thrust of the plunger causes the seal 28 at its lower edge to tightly engage the curved Wall of the end member and thus hold the parts in a leak preventing position.
  • the needle I5 forces the boss on the end member 30 outwardly so that leakage is prevented, also the engagement between the rounded portion I'I of the front member and the seal tends to force the seal against the needle to prevent leakage.
  • Figs. 4 and 5 I have indicated a slight modication of my invention generally at 50.
  • the closure member, barrel, and plunger are similar to those previously described and similar parts have been indicated by similarly primed reference characters.
  • the front member of the modification indicated at 5I is provided with a reduced portion 52 having an aperture 53 which at its lower end includes a rounded seat 54.
  • a needle 55 has a ball-like member 56 engaging the seat 54 while a cap 51 which is threaded to the front member 5I includes a seat 58 which engages the ball member 56 to hold the parts assembled.
  • the needle includes an injection point 59 and an ampoule piercing point 6U.
  • the ampoule shown in Fig. 4 is similar to the ampoule previously described but the front member 5I instead of being provided with a rounded recess to receive the ampoule has a plane end wall 6I and may be provided with a sharpened protuberance 62 surrounding the aperture 53.
  • the ampoule In use the ampoule is inserted in the barrel and the closure I8 is replaced. The head 23 then urges the ampoule forward in the barrel. The plunger is then operated causing the head 2I to engage the head portion 36 of the cork and thus pushing the portion inwardly and discharging the medicinal contents into the ampoule. The needle 55 is then inserted so that the point 6I] thereof passes through the seal on the ampoule whereupon the cap 5l' is secured in place.
  • a barrel 65 is provided with a threaded end closure 66 which includes a tapered recess 61 engaging an ampoule 68.
  • threads on the closure 66 are preferably triple threads and they are suiciently long so that the closure will engage ampoules of various lengths.
  • the ampoule 68 is of a uniform diameter throughout and is provided with a seal 69 which includes an inner layer of rubber and an outer layer which is of tough, flexible, material, previously described, such as Celluloid.
  • the rubber seal l0 includes a circumferential bead 'I2 and a peripheral bead 'I2' which engage the plane end face 'I3 of a front member 'I4 which is provided with a central bore I5.
  • the beads 'I2 and 'I2' are within and without the end of the ampoule thus when pressure is applied these tend to force the seal so that it has a tendency to wrap around the end of the ampoule.
  • the front member 'I4 is preferably secured to the barrel by spinning the front portion of the barrel 'I6 into a recess 'I'I in the front member.
  • an ampoule is inserted in the barrel and the closure is tightened and the ampoule is pushed forward so that the protuberances 'I2 and I2 of the seal engage the plane face 'I3 of the front member.
  • a needle 'I9 may then be inserted in the bore 'I5 and forced through the seal with a ball on the needle engaging a recess 8
  • a plunger 83 passes through the closure 66 and has a head B4 thereon which engages a cork 35 similar to the cork previously described so that when the plunger is operated the preparation is rst discharged. After this preparation has been distributed throughout the uid in the ampule the injection is made.
  • a cork for use in an ampoule said cork including a body having a protuberance at one end, said body having a boss on the face opposite said protuberance and having a skirt surrounding said boss, a disk engaging the inner wall of said skirt and a medicinal preparation in said cork between said disk and said boss.
  • An ampoule having a cylindrical wall and having a cork therein, said cork being made of rubber including a body having a protuberance at the outer end, said body having a boss on the face opposite said protuberance and having a skirt spaced from said boss, said skirt having a circumferentialrecess on the inner wall thereof, a disk seated in said recess and a medicinal preparation engaging said disk.

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Description

A. E. SMITH AMPOULE SYRINGE May v9, 1939.
Filed April 10, 1936 2 Sheets-Sheet l A. E. SMITH AMPOULE SYRINGE May 9, l939.
Filed April lO, 1956 2 SheetS-Shee 2 INVENTOR. ARTHUR E. SM/TH.
ATTORN Patented May 9, 1939 UNITED STATES AMPOULE SYRINGE Arthur E. Smith,
Application April 10,
2 Claims.
This invention relates to syringes.
The general object of the invention is to provide an improved syringe which is particularly adapted for use in connection with ampoules.
A further object of the invention is to provide an improved ampoule for use in a syringe.
An additional object of the invention is to provide a syringe and ampoule wherein novel means is provided for preventing leakage at the front end of the ampoule.
Another object of the invention is to provide a novel cork for use in an ampoule.
Another object of the invention is to provide novel means for sealing an ampoule.
Other objects and the advantages of the invention will be apparent from the following description taken in connection with the accompanying drawings, wherein:
Fig. 1 is a central, sectional View through a 20 syringe and ampoule embodying the features of my invention;
Fig. 2 is an enlarged, fragmentary, central, sectional, View through the upper end of my improved ampoule showing the cork therein;
Fig, 3 is an enlarged, fragmentary, central, sectional view showing the upper end of the ampoule with the cork engaged by the plunger;
Fig. 4 is a view similar to Fig. 1 showing a slight modication of my invention;
Fig. 5 is an enlarged, fragmentary, sectional view showing the front end of the modified syringe;
Fig. 6 is a view similar to Fig. 1 showing a further modii'lcatiom and Fig. 7 is an enlarged, fragmentary, sectional View showing the lower end of the syringe shown in Fig. 6.
Referring to the drawings by reference characters I have shown my invention as embodied in a syringe which is indicated generally at I0. As shown the syringe includes a barrel I I having a front member I2 threaded therein. This front member is provided with a threaded front end on which a needle I3 is mounted. The front member is also provided with a closure piercing member or needle I4 which is fixed thereon and which is provided at its inner end I5 with a sharpened portion which projects into a recess in the front member. The outer end of the front member recess is shown as cylindrical as at I6, while the inner portion is rounded as at I1.
Opposite the front member the barrel is provided with a closure I8 which is threaded as at I9 to the barrel and slidably mounted within the closure is a plunger rod 20 having a head 2I on Los Angeles, Calif.
1936, Serial No. 73,654
(Cl. 12S-218) the lower end thereof. Surrounding the plunger rod and fitted within the closure I8 are a plurality of segmental members 22 which are in telescopic engagement with the lower member having an ampoule engaging head 23 thereon. 'Ihis head includes a skirt 24 which receives the head 2I on the plunger. The plunger rod 20 is surrounded by a spring 25 which engages the head 23 and tends to urge the head away from the closure.
Mounted Within the barrel I show a removable ampoule 26 which is preferably made of glass and which is cylindrical in form with the upper end of the ampoule engaged by the skirt 24 on the head 23 of the plunger. The front end of the ampoule is of reduced diameter as at 2'I and on the reduced portion I mount a seal 28 comprising an inner cap which is preferably made of rubber. This cap includes a skirt 29 which tightly engages the end of the ampoule and the skirt is provided with an end portion 30 which is shown as slightly thicker than the skirt and which includes a boss which extends into the ampoule. Over the skirt I place a cap or covering of thin, exible, transparent material such as Celluloid, collodion, regenerated cellulose such as Cellophane, or other material preferably of a nature so that it shrinks when it dries and thus tightly engages the rubber closure and causes this closure to tightly engage the neck of the ampoule. The covering is shown as extending down onto the neck as at 3| and thus a tight seal is secured.
This seal, it will be noted, consists of two separate media both of which are impervious but are capable of being penetrated by the sharpened end I5 of the needle with the outer member tough and more resistant so that it will in a measure serve as a protection for the rubber member.
The rear end of the ampoule is provided with a cork 35 which includes a protuberant head portion 36 and a side wall 31. Within the side Wall 37 and preferably spaced therefrom is an internal boss 38 which terminates short of the end of the side wall. 'Ihe slide wall is provided on its inner surface with a peripheral groove 39 in which a sealing disk 43 which may be made of Celluloid is seated. This disk 40 serves to hold a medicinal preparation shown as a tablet 4I in place in the cork. The tablet 4I is shown as contacting the lower face of the boss 38 and the disk 40.
In use pressure is applied to the head portion 36 of the cork thus pushing the boss 38 inwardly so that the tablet 4I causes the disk l0 to be unseated. The closure I8 is then removed and the ampoule is placed in the barrel of the syringe and the closure is replaced. The spring 25 acting through the skirt 24 pushes the ampoule forwardly so that the needle point I5 pierces the seal 28. The seal 28 engages the rounded portion I'I on the front member on the syringe.
The interior of the ampoule is filled with a suitable vehicle for the medicinal preparation 4I and thus when the steps mentioned have occurred the preparation 4I is discharged into the vehicle in the ampoule and a fresh solution of material is provided. To make an injection the plunger 20 is forced inwardly thus causing the cork 36 to move within the ampoule and causing the material to pass out through the needle I3. The pressure of the spring 25, together with this forward thrust of the plunger causes the seal 28 at its lower edge to tightly engage the curved Wall of the end member and thus hold the parts in a leak preventing position. The needle I5 forces the boss on the end member 30 outwardly so that leakage is prevented, also the engagement between the rounded portion I'I of the front member and the seal tends to force the seal against the needle to prevent leakage.
In Figs. 4 and 5 I have indicated a slight modication of my invention generally at 50. In this modification the closure member, barrel, and plunger are similar to those previously described and similar parts have been indicated by similarly primed reference characters.
The front member of the modification indicated at 5I is provided with a reduced portion 52 having an aperture 53 which at its lower end includes a rounded seat 54. A needle 55 has a ball-like member 56 engaging the seat 54 while a cap 51 which is threaded to the front member 5I includes a seat 58 which engages the ball member 56 to hold the parts assembled. The needle includes an injection point 59 and an ampoule piercing point 6U. The ampoule shown in Fig. 4 is similar to the ampoule previously described but the front member 5I instead of being provided with a rounded recess to receive the ampoule has a plane end wall 6I and may be provided with a sharpened protuberance 62 surrounding the aperture 53.
In use the ampoule is inserted in the barrel and the closure I8 is replaced. The head 23 then urges the ampoule forward in the barrel. The plunger is then operated causing the head 2I to engage the head portion 36 of the cork and thus pushing the portion inwardly and discharging the medicinal contents into the ampoule. The needle 55 is then inserted so that the point 6I] thereof passes through the seal on the ampoule whereupon the cap 5l' is secured in place.
In Fig. 6 I have shown a further modification of my invention wherein a barrel 65 is provided with a threaded end closure 66 which includes a tapered recess 61 engaging an ampoule 68. 'Ihe threads on the closure 66 are preferably triple threads and they are suiciently long so that the closure will engage ampoules of various lengths. The ampoule 68 is of a uniform diameter throughout and is provided with a seal 69 which includes an inner layer of rubber and an outer layer which is of tough, flexible, material, previously described, such as Celluloid. The rubber seal l0 includes a circumferential bead 'I2 and a peripheral bead 'I2' which engage the plane end face 'I3 of a front member 'I4 which is provided with a central bore I5. The beads 'I2 and 'I2' are within and without the end of the ampoule thus when pressure is applied these tend to force the seal so that it has a tendency to wrap around the end of the ampoule.
The front member 'I4 is preferably secured to the barrel by spinning the front portion of the barrel 'I6 into a recess 'I'I in the front member.
In use of the syringe shown in Figs. 6 and '7 an ampoule is inserted in the barrel and the closure is tightened and the ampoule is pushed forward so that the protuberances 'I2 and I2 of the seal engage the plane face 'I3 of the front member. A needle 'I9 may then be inserted in the bore 'I5 and forced through the seal with a ball on the needle engaging a recess 8| of the front member after which a cap 82 is screwed onto the front member.
A plunger 83 passes through the closure 66 and has a head B4 thereon which engages a cork 35 similar to the cork previously described so that when the plunger is operated the preparation is rst discharged. After this preparation has been distributed throughout the uid in the ampule the injection is made.
From the foregoing description it will be apparent that I have invented a novel syringe and ampoule which can be economically manufactured and which is highly efficient in use.
Having thus described my invention I claim:
l. A cork for use in an ampoule, said cork including a body having a protuberance at one end, said body having a boss on the face opposite said protuberance and having a skirt surrounding said boss, a disk engaging the inner wall of said skirt and a medicinal preparation in said cork between said disk and said boss.
2. An ampoule having a cylindrical wall and having a cork therein, said cork being made of rubber including a body having a protuberance at the outer end, said body having a boss on the face opposite said protuberance and having a skirt spaced from said boss, said skirt having a circumferentialrecess on the inner wall thereof, a disk seated in said recess and a medicinal preparation engaging said disk.
ARTHUR E. SMITH.
US73654A 1936-04-10 1936-04-10 Ampoule syringe Expired - Lifetime US2157503A (en)

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Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2608972A (en) * 1948-02-23 1952-09-02 Chrigstrom Knut Vilhelm Guide for hypodermic syringes
US2629379A (en) * 1951-02-21 1953-02-24 Abbott Lab Puncture indicating closure for multiple dose vials
US3080866A (en) * 1961-07-07 1963-03-12 Friedman Benjamin Hypodermic needle
US3092108A (en) * 1954-04-09 1963-06-04 Friedman Benjamin Syringes and/or hypodermic needles, and cartridges therefor
US3618603A (en) * 1969-01-29 1971-11-09 Levenson M F Syringe
US3838690A (en) * 1971-07-14 1974-10-01 B Friedman Replaceable cartridge hypodermic syringe having sterile maintenance of needle
US4966585A (en) * 1988-05-31 1990-10-30 Gangemi Ronald J Infusion apparatus
US5336200A (en) * 1992-03-10 1994-08-09 Injectimed, Inc. Retractable sleeve-protection for injection apparatus employing carpules
FR2780653A1 (en) * 1998-07-03 2000-01-07 Alain Villette SEALING DEVICE FOR A CARPULE
WO2011045386A3 (en) * 2009-10-16 2011-06-30 Sanofi-Aventis Deutschland Gmbh Arrangement for use in a drug delivery device
US20140114274A1 (en) * 2009-08-21 2014-04-24 Becton Dickinson France S.A.S. "Pre-Filled Active Vial Having Integral Plunger Assembly"
EP3028729A1 (en) 2014-12-05 2016-06-08 ELM-Plastic GmbH Injector for dispensing a liquid or paste substance, in particular a medicament
DE102015002234A1 (en) * 2014-12-05 2016-06-09 Elm - Plastic Gmbh Injector for dispensing a liquid or pasty substance, in particular medicament
US20180333534A1 (en) * 2014-12-22 2018-11-22 Novo Nordisk A/S An injection device with a removable cap
WO2020245234A1 (en) * 2019-06-05 2020-12-10 Sanofi Medicament container
US11129934B2 (en) * 2014-10-28 2021-09-28 Bayer Healthcare Llc Self-orienting pressure jacket and pressure jacket-to-injector interface
US11191893B2 (en) 2018-01-31 2021-12-07 Bayer Healthcare Llc System and method for syringe engagement with injector
US11419977B2 (en) 2014-10-28 2022-08-23 Bayer Healthcare Llc Self-orienting syringe and syringe interface
US11577022B2 (en) 2014-10-28 2023-02-14 Bayer Healthcare Llc Self-orienting syringe and syringe interface

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2608972A (en) * 1948-02-23 1952-09-02 Chrigstrom Knut Vilhelm Guide for hypodermic syringes
US2629379A (en) * 1951-02-21 1953-02-24 Abbott Lab Puncture indicating closure for multiple dose vials
US3092108A (en) * 1954-04-09 1963-06-04 Friedman Benjamin Syringes and/or hypodermic needles, and cartridges therefor
US3080866A (en) * 1961-07-07 1963-03-12 Friedman Benjamin Hypodermic needle
US3618603A (en) * 1969-01-29 1971-11-09 Levenson M F Syringe
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