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US20040106867A1 - Non-invasive ultrasonic body contouring - Google Patents

Non-invasive ultrasonic body contouring Download PDF

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Publication number
US20040106867A1
US20040106867A1 US10/250,955 US25095503A US2004106867A1 US 20040106867 A1 US20040106867 A1 US 20040106867A1 US 25095503 A US25095503 A US 25095503A US 2004106867 A1 US2004106867 A1 US 2004106867A1
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United States
Prior art keywords
adipose tissue
ultrasonic energy
target volume
lysing
target
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/250,955
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English (en)
Inventor
Yoram Eshel
Ilia Vitsnudel
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Ultrashape Inc
Original Assignee
Ultrashape Inc
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Filing date
Publication date
Priority claimed from US09/752,530 external-priority patent/US6607498B2/en
Priority claimed from US10/021,238 external-priority patent/US7347855B2/en
Application filed by Ultrashape Inc filed Critical Ultrashape Inc
Assigned to ULTRASHAPE INC. reassignment ULTRASHAPE INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ESHEL, YORAM, VITSNUDEL, ILIA
Publication of US20040106867A1 publication Critical patent/US20040106867A1/en
Priority to US11/808,632 priority Critical patent/US7815570B2/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00084—Temperature
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2251—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient
    • A61B2017/2253—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient using a coupling gel or liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2046—Tracking techniques
    • A61B2034/2065—Tracking using image or pattern recognition
    • A—HUMAN NECESSITIES
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    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2072—Reference field transducer attached to an instrument or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3937—Visible markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/25—User interfaces for surgical systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/361—Image-producing devices, e.g. surgical cameras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0008—Destruction of fat cells

Definitions

  • the present invention relates to lipolysis generally and more particularly to ultrasonic lipolysis.
  • the present invention seeks to provide improved apparatus and methodology for ultrasonic lipolysis.
  • a method for lysing adipose tissue including the steps of:
  • a method for lysing adipose tissue including the steps of:
  • apparatus for lysing adipose tissue including:
  • a focused ultrasonic energy director directing focused ultrasonic energy at a target volume in a region of a body containing adipose tissue
  • a modulator cooperating with the energy director to produce a focused ultrasonic energy so as to selectively lyse the adipose tissue in the target volume and generally not lyse non-adipose tissue in the target volume.
  • apparatus for lysing adipose tissue including:
  • an ultrasonic energy director which employs the ultrasonic energy to selectively generally lyse adipose tissue and generally not lyse non-adipose tissue in a target volume of a body containing adipose tissue.
  • a region definer defining a region in a body at least partially by detecting spatial indications on the body
  • a director directing ultrasonic energy at a multiplicity of target volumes within the region, which target volumes contain adipose tissue thereby to selectively lyse the adipose tissue in the target volumes and generally not lyse non-adipose tissue in the target volumes.
  • apparatus for lysing adipose tissue including:
  • a director directing ultrasonic energy at a multiplicity of target volumes within the region, which target volumes contain adipose tissue, thereby to selectively lyse the adipose tissue in the target volumes and generally not lyse non-adipose tissue in the target volumes;
  • directing focused ultrasonic energy generally prevents lysis of tissue outside of the target volume.
  • the method also includes ultrasonic imaging of the region at least partially concurrently with directing the focused ultrasonic energy at the target volume.
  • directing includes positioning at least one ultrasonic transducer relative to the body in order to direct the focused ultrasonic energy at the target volume.
  • the directing may also include varying the focus of at least one ultrasonic transducer in order to direct the focused ultrasonic energy at the target volume. Varying the focus may change the volume of the target volume, and/or the distance of the target volume from the at least one ultrasonic transducer.
  • the directing may also include positioning at least one ultrasonic transducer relative to the body in order to direct the focused ultrasonic energy at the target volume.
  • the method preferably also includes sensing ultrasonic energy coupling to an external surface of the body adjacent the target volume.
  • the method preferably additionally includes sensing of cavitation at the target volume.
  • directing takes place from an ultrasonic transducer located outside of the body.
  • the ultrasonic energy has a frequency in a range of 50 KHz-1000 KHz, more preferably in a range of 100 KHz-500 KHz, and most preferably in a range of 150 KHz-300 KHz.
  • the modulating provides a duty cycle between 1:2 and 1:250, more preferably between 1:5 and 1:30 and most preferably between 1:10 and 1:20.
  • the modulating provides between 2 and 1000 sequential cycles at an amplitude above a cavitation threshold, more preferably between 25 and 500 sequential cycles at an 15 amplitude above a cavitation threshold and most preferably between 100 and 300 sequential cycles at an amplitude above a cavitation threshold.
  • the modulating includes modulating the amplitude of the ultrasonic energy over time.
  • directing includes directing focused ultrasonic energy at a multiplicity of target volumes in a time sequence.
  • directing includes directing focused ultrasonic energy at plural ones of the multiplicity of target volumes at times which at least partially overlap.
  • At least some of the multiplicity of target volumes at least partially overlap in space.
  • the method includes defining the region by marking at least one surface of the body.
  • the method may also include defining the region by selecting at least one depth in the body and/or by detecting adipose tissue in the body and/or by detecting non-lysed adipose tissue.
  • directing also includes defining the target volumes as unit volumes of non-lysed adipose tissue within the region.
  • modulating the ultrasonic energy so as to selectively lyse the adipose tissue in the multiplicity of target volumes proceeds sequentially in time wherein selective lysis of adipose tissue in each target volume takes place only following detection of non-lysed adipose tissue therein.
  • the method also includes computerized tracking of the multiplicity of target volumes notwithstanding movement of the body.
  • the computerized tracking includes sensing changes in the position of markings on the body and employing sensed changes for tracking the positions of the target volumes in the body.
  • the modulation provides a decreasing amplitude over time which exceeds a cavitation threshold.
  • FIG. 1 is a simplified pictorial illustration of the general structure and operation of ultrasonic lipolysis apparatus constructed and operative in accordance with a preferred embodiment of the present invention
  • FIG. 2 is a simplified block diagram illustration of a preferred power source and modulator showing a pattern of variation of ultrasonic pressure over time in accordance with a preferred embodiment of the present invention
  • FIGS. 3A and 3B are simplified pictorial illustrations of the appearance of an operator interface display during normal operation and faulty operation respectively;
  • FIG. 4 is a simplified block diagram illustration of an ultrasonic lipolysis system constructed and operative in accordance with a preferred embodiment of the present invention.
  • FIGS. 5A, 5B and 5 C are together a simplified flowchart illustrating operator steps in carrying out lipolysis in accordance with a preferred embodiment of the present invention.
  • the Appendix includes computer listings which, taken together, form a computational tracking functionality in accordance with a preferred software embodiment of the present invention.
  • FIG. 1 is a simplified pictorial illustration of the general structure and operation of ultrasonic lipolysis apparatus constructed and operative in accordance with a preferred embodiment of the present 10 invention.
  • an ultrasonic energy generator and director such as an ultrasonic transducer 10 , disposed outside a body, generates ultrasonic energy which, by suitable placement of the transducer 10 relative to the body, is directed to a target-volume 12 inside the body and is operative to selectively generally lyse adipose tissue and generally not lyse non-adipose tissue in the target volume.
  • a preferred embodiment of ultrasonic energy generator and director useful in the present invention comprises an ultrasonic therapeutic transducer 13 including a curved phased array 14 of piezoelectric elements 15 , typically defining a portion of a sphere or of a cylinder, and having conductive coatings 16 on opposite surfaces thereof.
  • the piezoelectric elements 15 may be of any suitable configuration, shape and distribution.
  • An intermediate element 18 formed of a material, such as polyurethane, which has acoustic impedance similar to that of soft mammalian tissue, generally fills the curvature defined by phased array 14 and defines a contact surface 20 for engagement with the body, typically via a suitable coupling gel (not shown). Contact surface 20 may be planar, but need not be.
  • Suitable modulated AC electrical power is supplied by conductors 22 to conductive coatings 16 to cause the piezoelectric elements 15 to provide a desired focused acoustic energy output.
  • an imaging ultrasonic transducer subassembly 23 is incorporated within transducer 10 and typically comprises a piezoelectric element 24 having conductive surfaces 26 associated with opposite surfaces thereof.
  • Suitably modulated AC electrical power is supplied by conductors 32 to conductive surfaces 26 in order to cause the piezoelectric element 24 to provide an acoustic energy output.
  • Conductors 32 coupled to surfaces 26 , also provide an imaging output from imaging ultrasonic transducer subassembly 23 .
  • ultrasonic transducers 10 may be employed.
  • such transducers may include multiple piezoelectric elements, multilayered piezoelectric elements and piezoelectric elements of various shapes and sizes arranged in a phase array.
  • the ultrasonic energy generator and director are combined in transducer 10 .
  • the functions of generating ultrasonic energy and focusing such energy may be provided by distinct devices.
  • a skin temperature sensor 34 such as an infrared sensor, may be mounted alongside imaging ultrasonic transducer subassembly 23 .
  • a transducer temperature sensor 36 such as a thermocouple, may also be mounted alongside imaging ultrasonic transducer subassembly 23 .
  • Ultrasonic transducer 10 preferably receives suitably modulated electrical power from a power source and modulator assembly 40 , forming part of a control subsystem 42 .
  • Control subsystem 42 also typically includes a lipolysis control computer 44 , having associated therewith a camera 46 , such as a video camera, and a display 48 .
  • a preferred embodiment of power source and modulator assembly 40 is illustrated in FIG. 2 and described hereinbelow.
  • Ultrasonic transducer 10 is preferably positioned automatically or semi-automatically as by an X-Y-Z positioning assembly 49 . Alternatively, ultrasonic transducer 10 may be positioned at desired positions by an operator.
  • camera 46 is operative for imaging a portion of the body on which lipolysis is to be performed.
  • a picture of the portion of the patient's body viewed by the camera is preferably displayed in real time on display 48 .
  • An operator may designate the outline of a region containing adipose tissue.
  • designation of this region is effected by an operator marking the skin of a patient with an outline 50 , which outline is imaged by camera 46 and displayed by display 48 and is also employed by the lipolysis control computer 44 for controlling the application of ultrasonic energy to locations within the region.
  • a computer calculated representation of the outline may also be displayed on display 48 , as designated by reference numeral 52 .
  • the operator may make a virtual marking on the skin, such as by using a digitizer (not shown), which also may provide computer calculated outline representation 52 on display 48 .
  • the functionality of the system of the present invention preferably also employs a plurality of markers 54 which are typically located outside the region containing adipose tissue, but may be located inside the region designated by outline 50 .
  • Markers 54 are visually sensible markers, which are clearly seen by camera 46 , captured by camera 46 and displayed on display 48 .
  • Markers 54 may be natural anatomic markers, such as distinct portions of the body or alternatively artificial markers such as colored stickers. These markers are preferably employed to assist the system in dealing with deformation of the region nominally defined by outline 50 due to movement and reorientation of the body.
  • the transducer 10 also bears a visible marker 56 which is also captured by camera 46 and displayed on display 48 .
  • Markers 54 and 56 are typically processed by computer 44 and may be displayed on display 48 as respective computed marker representations 58 and 60 on display 48 .
  • FIG. 1 illustrates the transducer 10 being positioned on the body over a location within the region containing adipose tissue.
  • Blocks designated by reference numerals 62 and 64 show typical portions of a region containing adipose tissue, respectively before and after lipolysis in accordance with a preferred embodiment of the invention. It is seen from a comparison of blocks 62 and 64 that, in accordance with a preferred embodiment of the present invention, within the region containing adipose tissue, the adipose tissue, designated by reference numeral 66 , is lysed, while non-adipose tissue, such as connective tissue, designated by reference numeral 68 , is not lysed.
  • FIG. 2 is a simplified block diagram illustration of a preferred power source and modulator assembly 40 (FIG. 1), showing a pattern of variation of ultrasonic pressure over time in accordance with a preferred embodiment of he present invention.
  • the power source and modulator assembly 40 preferably comprises a signal generator 100 which provides a time varying signal which is modulated so as to have a series of relatively high amplitude portions 102 separated in time by a series of typically relatively low amplitude portions 104 each relatively high amplitude portion 102 preferably corresponds to a cavitation period and preferably has a decreasing amplitude over time.
  • the relationship between the time durations of portions 102 and portions 104 is such as to provide a duty cycle between 1:2 and 1:250, more preferably between 1:5 and 1:30 and most preferably between 1:10 and 1:20.
  • the output of signal generator 100 has a frequency in a range of 50 KHz-1000 KHz, more preferably between 100 KHz-500 KHz and most preferably between 150 KHz-300 KHz.
  • the output of signal generator 100 is preferably provided to a suitable power amplifier 106 , which outputs via impedance matching circuitry 108 to an input of ultrasonic transducer 10 (FIG. 1), which converts the electrical signal received thereby to a corresponding ultrasonic energy output.
  • the ultrasonic energy output comprises a time varying signal which is modulated correspondingly to the output of signal generator 100 so as to having a series of relatively high amplitude portions 112 , corresponding to portions 102 , separated in time by a series of typically relatively low amplitude portions 114 , corresponding to portions 104 .
  • Each relatively high amplitude portion 102 preferably corresponds to a cavitation period and has an amplitude at a target volume 12 (FIG. 1) in the body which exceeds a cavitation maintaining threshold 120 and preferably has a decreasing amplitude over time. At least an initial pulse of each relatively high amplitude portion 112 has an amplitude at the target volume 12 , which also exceeds a cavitation initiation threshold 122 .
  • Relatively low amplitude portions 114 have an amplitude which lies below both thresholds 120 and 122 .
  • the relationship between the time durations of portions 112 and portions 114 is such as to provide a duty cycle between 1:2 and 1:250, more preferably between 1:5 and 1:30 and most preferably between 1:10 and 1:20.
  • the ultrasonic energy output of ultrasonic transducer 10 has a frequency in a range of 50 KHz-1000 KHz, more preferably between 100 KHz-500 KHz and most preferably between 150 KHz-300 KHz.
  • each high amplitude portion 112 is comprised of between 2 and 1000 sequential cycles at an amplitude above the cavitation maintaining threshold 120 , more preferably between 25 and 500 sequential cycles at an amplitude above the cavitation maintaining threshold 120 and most preferably between 100 and 300 sequential cycles at an amplitude above the cavitation maintaining threshold 120 .
  • FIGS. 3A and 3B are simplified pictorial illustrations of the appearance of an operator interface display during normal operation and faulty operation respectively.
  • display 48 typically shows a plurality of target volumes 12 (FIG. 1) within a calculated target region 200 , typically delimited by outline representation 52 (FIG. 1). Additionally, display 48 preferably provides one or more pre-programmed performance messages 202 and status messages 203 .
  • target volumes 12 are shown with different shading in order to indicate their treatment status.
  • unshaded target volumes here designated by reference numerals 204 have already experienced lipolysis.
  • a blackened target volume 12 designated by reference numeral 205 is the target volume next in line for lipolysis.
  • a partially shaded target volume 206 typically represents a target volume which has been insufficiently treated to achieve complete lipolysis, typically due to an insufficient treatment duration.
  • target volumes such as those not to be treated due to insufficient presence of adipose tissue therein or for other reasons, may be designated by suitable colors or other designations, and are here indicated by reference numerals 208 and 210 .
  • Typical performance messages 202 may include “CAVITATION IN PROCESS” and “FAT LYSED IN TIES VOLUME”.
  • Typical status messages 203 may include an indication of the power level, the operating frequency, the number of target volumes 12 within the calculated target region 200 and the number of target volumes 12 which remain to undergo lipolysis.
  • Display 48 also preferably includes an graphical cross sectional indication 212 derived from an ultrasonic image preferably provided by imaging ultrasonic transducer subassembly 23 (FIG. 1).
  • Indication 212 preferably indicates various tissues in the body in cross section and shows the target volumes 12 in relation thereto. In accordance with a preferred embodiment of the present invention, indication 212 may also provide a visually sensible indication of cavitation within the target volume 12 .
  • display 48 provides pre-programmed warning messages 214 .
  • Typical warning messages may include “BAD ACOUSTIC CONTACT”, “TEMPERATURE TOO HIGH”.
  • the “TEMPERATURE TOO HIGH” message typically relates to the skin tissue, although it may alternatively or additionally relate to other tissue inside or outside of the target volume or in transducer 10 (FIG. 1).
  • FIG. 4 illustrates an ultrasonic lipolysis system constructed and operative in accordance with a preferred embodiment of the present invention.
  • the ultrasonic lipolysis system comprises a lipolysis control computer 44 , which outputs to a display 48 .
  • Lipolysis control computer 44 preferably receives inputs from video camera 46 (FIG. 1) and from a temperature measurement unit 300 , which receives temperature threshold settings as well as inputs from skin temperature sensor 34 (FIG. 1) and transducer temperature sensor 36 (FIG. 1).
  • Temperature measurement unit 300 preferably compares the outputs of both sensors 34 and 36 with appropriate threshold settings and provides an indication to lipolysis control computer 44 of exceedance of either threshold.
  • Lipolysis control computer 44 also preferably receives an input from an acoustic contact monitoring unit 302 , which in turn preferably receives an input from a transducer electrical properties measurement unit 304 .
  • Transducer electrical properties measurement unit 304 preferably monitors the output of power source and modulator assembly 40 (FIG. 1) to ultrasonic therapeutic transducer 13 .
  • An output of transducer electrical properties measurement unit 304 is preferably also supplied to a power meter 306 , which provides an output to the lipolysis control computer 44 and a feedback output to power source and modulator assembly 40 .
  • Lipolysis control computer 44 also preferably receives inputs from cavitation detection functionality 308 , tissue layer identification functionality 310 and lysed adipose tissue identification functionality 312 , all of which receive inputs from ultrasonic reflection analysis functionality 3 14 .
  • Ultrasonic reflection analysis functionality 3 14 receives ultrasonic imaging inputs from an ultrasonic imaging subsystem 3 16 , which operates ultrasonic imaging transducer 23 (FIG. 1).
  • Lipolysis control computer 44 provides outputs to power source and modulator assembly 40 , for operating ultrasonic therapeutic transducer 13 , and to ultrasonic imaging subsystem 316 , for operating ultrasonic imaging transducer 23 .
  • a positioning control unit 318 also receives an output from lipolysis control computer 44 for driving X-Y-Z positioning assembly 49 (FIG. 1) in order to correctly position transducer 10 , which includes ultrasonic therapeutic transducer 13 and ultrasonic 15 imaging transducer 23 .
  • FIGS. 5A, 5B and 5 C are together a simplified flowchart illustrating operator steps in carrying out lipolysis in accordance with a preferred embodiment of the present invention.
  • an operator preferably draws an outline 50 (FIG. 1) on a patient's body.
  • the operator also adheres stereotactic markers 54 (FIG. 1) to the patient's body and places transducer 10 , bearing marker 56 , at a desired location within outline 50 .
  • Camera 46 captures outline 50 and markers 54 and 56 .
  • outline 50 and markers 54 and 56 are displayed on display 48 in real time.
  • the output of camera 46 is also preferably supplied to a memory associated with lipolysis control computer 44 (FIG. 1).
  • a computerized tracking functionality preferably embodied in lipolysis control computer 44 preferably employs the output of camera 46 for computing outline representation 52 , which may be displayed for the operator on display 48 .
  • the computerized tracking functionality also preferably computes coordinates of target volumes for lipolysis treatment, as well as adding up the total volume of tissue sought to undergo lipolysis.
  • the operator confirms the locations of markers 54 and 56 on display 48 and the computerized tracking functionality calculates corresponding marker representations 58 and 60 .
  • the computerized tracking functionality employs markers 54 and marker representations 58 for continuously maintaining registration of outline 50 with respect to outline representation 52 , and thus of target volumes 12 with respect to the patient's body, notwithstanding movements of the patients body during treatment, such as due to breathing or any other movements, such as the patient leaving and returning to the treatment location.
  • the computerized tracking functionality selects an initial target volume to be treated and positioning control unit 318 (FIG. 4), computes the required repositioning of transducer 10 .
  • X-Y-Z positioning assembly 49 repositions transducer 10 to overlie the selected target volume.
  • the lipolysis control computer 44 confirms accurate positioning of transducer 10 with respect to the selected target volume.
  • the ultrasonic imaging subsystem 316 (FIG. 4) operates ultrasonic imaging transducer 23 , causing it to provide an ultrasonic reflection analysis functionality 3314 for analysis.
  • the thicknesses of the various tissue layers of the patient are determined.
  • an operator may approve the selected target volume and activates the power source and modulator assembly 40 (FIG. 1).
  • Transducer electrical properties measurement unit 304 provides an output to acoustic contact monitoring unit 302 , which determines whether sufficient acoustic contact with the patient is present, preferably by analyzing the current and voltage at therapeutic transducer 13 .
  • Transducer electrical properties measurement unit 304 provides an output to power meter 306 , which computes the average electrical power received by the therapeutic transducer 13 . If the average electrical power received by the therapeutic transducer 13 exceeds a predetermined threshold, operation of the power source and modulator assembly 40 may be automatically terminated.
  • Skin temperature sensor 34 measures the current temperature of the skin at transducer 10 and supplies it to temperature measurement unit 300 , which compares the skin temperature to the threshold temperature.
  • transducer temperature sensor 36 measures the current temperature at transducer 10 and supplies it to temperature measurement unit 300 , which compares the transducer temperature to the threshold temperature.
  • the outputs of temperature measurement unit 300 are supplied to lipolysis control computer 44 .
  • the ultrasonic imaging subsystem 316 operates ultrasonic imaging transducer 23 and receives an imaging output, which is analyzed by ultrasonic reflection analysis functionality 314 . The result of this analysis is employed for cavitation detection and a cavitation detection output is supplied to lipolysis control computer 44 .
  • the power source and modulator assembly 40 automatically terminates operation of therapeutic transducer 13 . Should none of the following conditions occur, the automatic operation of power source and modulator assembly 40 continues:
  • video camera 46 preferably records the target region and notes whether the transducer 10 remained stationary during the entire treatment duration of the selected target volume 12 . If so, and if none of the aforesaid four conditions took place, lipolysis control computer 44 confirms that the selected target volume was treated. The computerized tracking functionality of lipolysis control computer 44 then proposes a further target volume 12 to be treated.
  • the selected target volume is designated by lipolysis control computer 44 as having been insufficiently treated.
  • multiplicity of target volumes can be treated at various time patterns such as sequential time patterns or partially overlapping time patterns.
  • multiplicity of target volumes may also overlap in space or partially overlap in space.
  • the Appendix includes a software object code for the computational functionality and includes the following steps:
  • PC computer such as an Intel-based Pentium III 800 MHz computer with Microsoft Windows 2000 operating system, a hard disk with a minimal capacity of 10 GB, 1 available PCI slot and a 17′′ computer screen.
  • the software components of the present invention may, if desired, be implemented in ROM (read-only memory) form.
  • the software components may, generally, be implemented in hardware, if desired, using conventional techniques.

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PCT/IL2001/001220 WO2002054018A2 (fr) 2001-01-03 2001-12-31 Systeme non invasif par ultrasons permettant de definir le contour d'un corps humain

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RU2003124635A (ru) 2005-01-27
JP2004522492A (ja) 2004-07-29
BR0116707A (pt) 2005-08-16
AU2002217412B2 (en) 2006-09-14
CN1484520A (zh) 2004-03-24
IL156439A0 (en) 2004-01-04
US7815570B2 (en) 2010-10-19
EP1362223A2 (fr) 2003-11-19
KR100948543B1 (ko) 2010-03-18
CN100370961C (zh) 2008-02-27
ATE395948T1 (de) 2008-06-15
US20080281201A1 (en) 2008-11-13
DE60134177D1 (de) 2008-07-03
EP1362223A4 (fr) 2005-07-06
CA2433745A1 (fr) 2002-07-11
EP1362223B1 (fr) 2008-05-21
JP2008212708A (ja) 2008-09-18
JP4727903B2 (ja) 2011-07-20
WO2002054018A2 (fr) 2002-07-11
HK1064277A1 (zh) 2005-01-28
WO2002054018A3 (fr) 2003-09-18
CA2433745C (fr) 2014-04-01
RU2295366C2 (ru) 2007-03-20
KR20040015045A (ko) 2004-02-18

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