US1645792A - Dentifrice - Google Patents

Description

Patented Oct. 18, 1927.

UNITED STATES 1,645,792 PATENT OFFICE.

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A problem encountered in compound a' satisfactory dentifrice "is to provide a substance which thoroughly cleanses the teeth; but which contains no; gritty ,substance capable of wearing away ting a solvent action thereon; l

A corollar function of a complete denti-;

issolve and com letely remove}. oils, fats, and mucin from t e teeth; thusfrice is to reventing the formation of tartar and other thereof.

A still further desirable property of a dentifrice is to be capable of exerting a mild antiseptic action, thus retarding the increase of bacteria within the oral cavity without injuring any tissues of the mouth or gums.

The dentifrice of the present invention meets these requirements y the incorporation therein of a substance which acts as a solvent of fats, oils, and mucin; and which has a mild antiseptic effect, without inuring the-teeth or tissues or impairing the ow or alkalinity of the saliva. 1

One substance having these desirable .40 properties for use in a dentifrice is the olyalide of methane, carbon tetrachlori e or tetrachlor methane (C01 Another substance having unusually desirable properties is ethyl iodide (C H I), which is the iodine substitution product of ethane.

While either of these substances alone is highly satisfactory as the sole active ingredient of a dentifrice, in combination they 1 present an almost ideal active principle for the urpose. This is because the carbon tetrach loride exerts a somewhat greater solvent and cleansin effect than the ethyl iodide, while the ct yliodide has somewhat higher antiseptic properties than the carbon 'Magnesium carbonate p e enamel ofthe teeth, and no ingredientcapable 'of exert 'fSo diu'm chloride d S ap eposits, and exposing the actual surface of the teeth to direct contact of the cleansing 5 instrument to secure a thorough cleansing Application filed October 18, 1928. Serial No. 141,486.

tetrachloride. Both these organic halides exert no 1n urious effect on the teeth or tissues.

As used in a dental cream, these active ingredients are combined with relatively inert substances which provide filling, carrying, and polishing material.

The following formula, is one which has been found to give satisfactory results:

Grams.

Calcium carbonate (prepared ehalk) Tetra-chlor-methane"; 20-30 Ethyl-iodide 3-10 Wh te mineral oil (hi hly refined petroleum oil of the lubricating grade) 40-50 Oil of ahise 5 ;:Eucaly 'tol 2-3 Mentho 1 2-3 10 Glyoerine 145 'Water 145 It should be understood that the formula given above is illustrative only, and that the ingredients other than the carbon tetrachloride and ethyl iodide may be varied in order to provide a dental cream of any desired consistency and flavor. The amount of carbon tetrachloride and eth l iodide ma also be varied, and as these substances are armless, they may be included in as great a combined amount as will remain in a uniform mechanical mixture with the other ingred1ents of the composition. There is also no definite lower limit to the amount of these substances which may be used, as any appreciable quantity will exert a beneficial effect. In order that the most advantageous results may be obtained, however it is desirable that the combined amount 0 carbon tetrachloride and ethyl iodide in the composition should be from one-twentieth of the total weight of the composition to an amount as great as may be retained in satisfactory condition therein. 1

Certain other organic halides ma be incorporated in the dentrifice to rep ace the carbon tetrachloride or ethyl iodide. Of the other halides of methane, di-iodo methane may be used in the composition if desired. On the trihalides of methane, chloroform may be used, although its high rate of evap- .in this connection the chloroform is included for its solvent and cleansing properties. Its antiseptic action is onl of secondary importance, while its anaest etic properties are wholly foreign to the urposes of the dentrifrice. Carbon tetra iodide ssesses physical and chemical properties w ich ren-l der its use possible and desirable.

Of the halides of the higher members of the paraflin series various substances may be advantageously utilized. Not only the monohalides of the paraflin series, but-also the di-halides and poly-halides of the series may be employed when their physical propertles render them suitable for use in a dentifrice.

In regard to any of these substances it may be stated as a general principle that the more desirable are those having a boiling point between twenty-five degrees centigrade and one hundred and fifty de 1 s. centigrade. To express the matter di erently, the more desirable are those which are liquids at room temperature and'atino'spheric pressure. The compounds having. a boiling point are too inactive to impart the desired quali ties to the dentifrice.

The halogen substitution products of several of the ethylene series of hydrocarbons may also be used instead of carbon tetrachloride in a dentifrice. Of these the most suitable member is ethylene chloride (C,H,Cl,) A number of the halides of the acetylene series also possess suitable characteristics.

It should be understood that a number of the halides of both the saturated and unsaturated series, which have physical properties rendering them suitable, are relatively so rare that their use in a dentifrice is rendered commercially impractical.

It should also be understood that odor, or taste, as well as boiling point, is of importance in considering the desirability of any compound from the view point of its physical properties. Thus many of the bromides have such a penetrating and disagreeable odor that their use is in effect precluded by the impossibility of using flavoring matter which will cover or neutralize the same.

A very desirable mixture is that of ethylene chloride together with either or both carbon tetrachloride and ethyl iodide. This is for the reason that ethylene chloride has a particularly sweet taste and pleasant odor, so that in itself it serves as a flavoring ingredient as well as exercising a solvent and antiseptic effect. When the ethylene chloride is used the mixture of active ingredients may desirably consist in ten to twenty (10 to 20%) per cent of the ethylene chloride, and the remainder of either or both carbon tetrachloride and ethyl iodide.

In addition to the dental cream, one or more halogen substitution products of hydrocarbons may be used in liquid form to secure an occasional thorough cleansing of the teeth. One such liquid may consist merely of a mixture of tetrachlor methane and ethyl iodide. To such mixture white mineral oil may be added, if so desired, to retard evaporation of these volatile li uids. A satisfactory formula for such liquld may be given as follows:

Grams. Tetrachlor methane 6 Ethyl iodide 1 Wh1te mineral oil 4 While white mineral oil is highly desirable because of its lack of taste and odor, various other mineral, animal, or vegetable oils may be substituted forit. For example,

highly refined olive oil or cottonseed oil may be emplo a What claim is: 1. A. dentifrice comprising as its princi al active ingredients a chloride of an alilower than twenty-five degrees centigrade tend to evaporate from or se arate inthe'. composition, while those whic are solid atf, room temperature and atmospherlc pressure atic hydrocarbon, and ethyl iodide.

A dentifrice com rising as its principal activeingredients car 11 tetrachloride, and an iodide of an aliphatic hydrocarbon.

f 3. A dental cream compnsin as its principal active ingredients a chloride of an aliphatic hydrocarbon and ethyl iodide; filling material, and a white mineral oil.

4. A dental cream comprising as its principal active ingredients carbon tetrachloride and an iodide of an ali 'hatic hydrocarbon; filling material, and a w ite mineral oil.

5. A dentifrice comprising a chloride of an aliphatic hydrocarbon and an iodide of an aliphatic hydrocarbon, each of such halides having its boiling point between the limits of twent -five degrees centigrade and one hundred fty degrees centigrade, the halides being present in a combined amount constituting no less than one-twentieth by weight of the total composition.

6. A dentifrice comprising at least two dlfi'erent halides of aliphatic hydrocarbons, each of such halides having its boilin point between the limits of twenty-five centigrade and one hundred fifty degrees centigrade, the halides being present in a combined amount constituting no less than one-twentieth by weight of the total composition.

7. A dental cream comprising achloride of an aliphatic hydrocarbon and an iodide of an aliphatic hydrocarbon, each of such halides having its boiling point between the limits of twenty-five degrees centigrade and one hundred fifty degrees centigrade, the halides being present in a combined amount no less than'one-twentieth by weight of the total composition, filling material, and a white mineral oil.

8. A dental cream comprisin two different halides of aliphatic h drocar ons, each of such halides having its oiling point between the limits of twenty-five 'degrees centigrade and one hundred fifty degrees centigrade, the halides being present in a combined amount no less than one-twentieth by weight of the total composition, filling material, and a. white mineral oil.

9. A dentifrice com rising carbon tetrachloride and ethyl i ide as its principal active ingredients.

10. A dental cream comprising carbontetrachloride, ethyl iodide, filling material, and a white mineral oil.

11. A dental preparation comprising carbon tetrachloride and ethyl iodide, both in liquid form.

12. A dental preparation comprising carbon tetrachloride and ethyl iodide, both in liquid form, and a white mineral oil.

13. A dental preparation comprising carbon tetrachloride and ethyl iodide, both in liquid form, and an oleaginous carrier for the halides.

In witness whereof, I hereunto set my hand.

ROY H. BROWNLEE.