US1381295A - Process for the manufacture of metal pyrophosphate casein compounds colloidally soluble in dilute alkaline solutions - Google Patents

Description

I phosphoric acid albumm compounds known th UNITED sures PATENT OFFICE.

ALBERT FREY, BASEL, SWITZERLAND CHEMICAL WORKS, 013

,ASSIGNOR TO THE HOFFMANN-LA ROCHE NEW YORK, N. Y., A CORPORATION OF NEW YORK.

Be it known that I, ALBERT FREY, a citizen of Switzerland, and a resident of Basel, zerland, have invented certain new and useful Improvements in Processes for the Manufacture of Metal Pyrophosphate Casein Compounds Colloidally Soluble in Dilute Alkaline Solutions, of which the following tak 1s a specification. U I E y invention relates to a new process for the manufacture of metal pyrophosphate casein compounds colloidally soluble in dilute alkaline solutions, which consists in dis solving casein in alkali pyrophosphate and adding another metal salt to this solution. Compounds which contain albumin, phosphoric acid and metals have already been used for therapeutic purposes. In view of the use" they are put to, such products should e quite easily soluble in alkali, because in such case only their absorption in the intestinal alkaline juice is assured. The metal heretofore meet these requirements not at all, or only partially. v

According to the processes known heretofore relating to the manufacture of metal phosphoric acid albumin compounds, casein 1s for instance dissolved in alkali and the alkaline solution treated with sodium phosphate and solutions of metal salts. In one instance it has been proposed to completely saturate the acid valences of casein by taking it up in an excess of alkali or alkaline earth, and to combine the metaphosphoric acid with the albumin molecule by adding metaphosphoric acid to the alkaline solu-, tion. Another processalready known describes in a similar manner the manufacture of tricalcium phosphate albumin compounds.

disadvantage products which are not soluble 0th these of yielding in alkali. In-order processes have the to render the products more easily soluble in alkali, it has been recommended touse greatly diluted solutions, but this is unfavorable in practice. It has further been proposed to use pyrophosphoric acid and its salts for the manufacture 0 calciumand iron-phosphoric acid al-' bumin compounds, soluble in alkali; here solubility Specification of Letters Patent.

' poses.

, tion of 112 ,cipitated by adding alcoho Patented June 14, 1921.

have the disadvantage of containing little phosphoric acid, which no doubt is to the addition of free alkali when combi11- mg the phosphoric acid with the albumin molecule. In the new process, casein, without havmg previously been dissolved in alkali, is

en up in a solution of alkali pyrophosphate and another metal salt added to the solution. The resulting product meets all requlrements. By the simpl solving in alkali pyro nation of phosphoric he mixture shows an acid reaction after the addition of the metal salt, by which fact the transformation distinguishes itself from the processes known heretofore, which latter erlrliploy an alkaline solution. P

e metal Ewample I.

. 66 parts of casein are dissolved in a soluparts of crystallized sodium pyrophosphate and 800 parts of water and, while stirring, 156 parts of a four times normal solution of calcium chlorid are added to the mixture. The new compound is pre- After having C. The prodpyrophosphate its solutions in sodium bicarbonate and dilgfedsolution of sodium carbonate are sta e.

been washed it is dried at Example 2.

6.6 parts of casein are dissolved in a solution of 11.2 parts of sodium and 120 parts of water and to this 19.5 arts of a 23% solution of ferric-chlorid are a ded, w 'le stirring. he compound obtained is precipitated with alcohol, washed and dried at 50 C It contains 50% of ferricphosphate. The product is easily soluble in alkali; the solutions are stable.

claim: 1. As a new article of manufacture the pyrophosphate 10 which comprises metal pyrophosphate casein compounds colloidally soluble in dilute alkaline solutions, which are entirely soluble in alkali; the solutions of this'compound in sodium bicareonate and diluted solutions of sodium car- 4 leonate are stable.

2. llhe process for the manufacture of metal pyrophosphate casein compounds colloidally soluble in dilute alkaline solutions dissolving casein in alkali v memes pyrophosphate adding a metal salt to this solution and precipitating the compound thus produced.

In witness whereof I have hereunto set my hand.

ALBERTFREY;

Witnesses Harmon Knnm, HUBERT Ramon.