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UA97256C2 - Замещенные пиразолы и триазолы как ингибиторы кбв (кинезин-белок веретена) - Google Patents

Замещенные пиразолы и триазолы как ингибиторы кбв (кинезин-белок веретена)

Info

Publication number
UA97256C2
UA97256C2 UAA200904556A UAA200904556A UA97256C2 UA 97256 C2 UA97256 C2 UA 97256C2 UA A200904556 A UAA200904556 A UA A200904556A UA A200904556 A UAA200904556 A UA A200904556A UA 97256 C2 UA97256 C2 UA 97256C2
Authority
UA
Ukraine
Prior art keywords
ksp
inhibitors
triazole compounds
substituted pyrazole
spindle protein
Prior art date
Application number
UAA200904556A
Other languages
English (en)
Ukrainian (uk)
Inventor
Йи Ксиа
Крис Г. Менденхолл
Пол А. Барсанти
Аннетт О. Уолтер
Девид Дул
Пол А. Ренхоув
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of UA97256C2 publication Critical patent/UA97256C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В заявке описаны замещенные пиразолы и триазолы формулы (I) и их фармацевтически приемлемые соли, сложные эфиры или пролекарства, композиции производных вместе с фармацевтически приемлемыми носителями, и их применение.(I)
UAA200904556A 2006-11-13 2007-11-08 Замещенные пиразолы и триазолы как ингибиторы кбв (кинезин-белок веретена) UA97256C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85896406P 2006-11-13 2006-11-13
PCT/US2007/084154 WO2008063912A1 (en) 2006-11-13 2007-11-08 Substituted pyrazole and triazole compounds as ksp inhibitors

Publications (1)

Publication Number Publication Date
UA97256C2 true UA97256C2 (ru) 2012-01-25

Family

ID=39144618

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200904556A UA97256C2 (ru) 2006-11-13 2007-11-08 Замещенные пиразолы и триазолы как ингибиторы кбв (кинезин-белок веретена)

Country Status (32)

Country Link
US (2) US7902240B2 (ru)
EP (1) EP2091926B1 (ru)
JP (1) JP5264755B2 (ru)
KR (1) KR20090081020A (ru)
CN (1) CN101558049B (ru)
AR (1) AR063805A1 (ru)
AU (1) AU2007323998B2 (ru)
BR (1) BRPI0719002A2 (ru)
CA (1) CA2668661A1 (ru)
CL (1) CL2007003272A1 (ru)
CO (1) CO6382171A2 (ru)
CR (1) CR10787A (ru)
DO (1) DOP2009000106A (ru)
EA (1) EA017748B1 (ru)
EC (1) ECSP099326A (ru)
ES (1) ES2557478T3 (ru)
GE (1) GEP20125389B (ru)
GT (1) GT200900122A (ru)
HN (1) HN2009000968A (ru)
IL (1) IL198471A0 (ru)
MA (1) MA30959B1 (ru)
MX (1) MX2009005071A (ru)
NI (1) NI200900084A (ru)
NO (1) NO20092226L (ru)
NZ (1) NZ576640A (ru)
PE (1) PE20081169A1 (ru)
SM (1) SMP200900045B (ru)
TN (1) TN2009000178A1 (ru)
TW (1) TW200831480A (ru)
UA (1) UA97256C2 (ru)
WO (1) WO2008063912A1 (ru)
ZA (1) ZA200902940B (ru)

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US7902240B2 (en) * 2006-11-13 2011-03-08 Novartis Ag Substituted pyrazole and triazole compounds as KSP inhibitors
CA2674318A1 (en) * 2007-01-05 2008-07-17 Novartis Ag Cyclized derivatives as eg-5 inhibitors
WO2011128381A1 (en) * 2010-04-15 2011-10-20 Novartis Ag Triazole compounds as ksp inhibitors
EP2558452A2 (en) * 2010-04-15 2013-02-20 Novartis AG Oxazole and thiazole compounds as ksp inhibitors
BR112015012843B8 (pt) * 2012-12-05 2023-04-25 Merck Sharp & Dohme Método para sintetizar o composto
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
CN105451773A (zh) * 2013-03-15 2016-03-30 诺华股份有限公司 细胞增殖抑制剂及其缀合物
WO2015084763A2 (en) 2013-12-04 2015-06-11 Merck Sharp & Dohme Corp. Process for making reverse transcriptase inhibitors
US10786578B2 (en) 2014-08-05 2020-09-29 Novartis Ag CKIT antibody drug conjugates
WO2017097927A1 (en) * 2015-12-11 2017-06-15 Syngenta Participations Ag Pesticidally active 1,2,4-triazole derivatives
AU2020417293A1 (en) 2020-01-03 2022-09-01 Berg Llc Polycyclic amides as UBE2K modulators for treating cancer

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Also Published As

Publication number Publication date
TW200831480A (en) 2008-08-01
CO6382171A2 (es) 2012-02-15
AU2007323998A1 (en) 2008-05-29
US20100034813A1 (en) 2010-02-11
CL2007003272A1 (es) 2008-03-24
BRPI0719002A2 (pt) 2013-12-17
IL198471A0 (en) 2010-02-17
EP2091926B1 (en) 2015-10-21
AR063805A1 (es) 2009-02-18
GT200900122A (es) 2011-09-14
AU2007323998B2 (en) 2011-09-22
CR10787A (es) 2009-07-02
ZA200902940B (en) 2010-05-26
DOP2009000106A (es) 2009-05-31
PE20081169A1 (es) 2008-09-24
SMAP200900045A (it) 2009-07-14
US20080200462A1 (en) 2008-08-21
GEP20125389B (en) 2012-01-25
ECSP099326A (es) 2009-06-30
MA30959B1 (fr) 2009-12-01
US7902240B2 (en) 2011-03-08
CA2668661A1 (en) 2008-05-29
JP2010509365A (ja) 2010-03-25
NI200900084A (es) 2010-01-29
EA200900631A1 (ru) 2009-12-30
EA017748B1 (ru) 2013-02-28
NO20092226L (no) 2009-08-12
JP5264755B2 (ja) 2013-08-14
MX2009005071A (es) 2009-05-25
CN101558049B (zh) 2012-08-15
SMP200900045B (it) 2010-03-01
CN101558049A (zh) 2009-10-14
TN2009000178A1 (en) 2010-10-18
WO2008063912A1 (en) 2008-05-29
ES2557478T3 (es) 2016-01-26
EP2091926A1 (en) 2009-08-26
US8129358B2 (en) 2012-03-06
NZ576640A (en) 2011-10-28
HN2009000968A (es) 2011-10-25
KR20090081020A (ko) 2009-07-27

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