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UA97229C2 - Isolated monoclonal antibody that specifically binds to toll like receptor 3 (tlr3) - Google Patents

Isolated monoclonal antibody that specifically binds to toll like receptor 3 (tlr3)

Info

Publication number
UA97229C2
UA97229C2 UAA200706796A UAA200706796A UA97229C2 UA 97229 C2 UA97229 C2 UA 97229C2 UA A200706796 A UAA200706796 A UA A200706796A UA A200706796 A UAA200706796 A UA A200706796A UA 97229 C2 UA97229 C2 UA 97229C2
Authority
UA
Ukraine
Prior art keywords
antibody
tlr3
toll
receptor
specifically binds
Prior art date
Application number
UAA200706796A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Джилл Картон
Марк Каннингхем
Анук Дас
Карен Даффи
Девид М. Найт
Роберта Ламб
Моухамадоу Л. Мбоу
Гопалан Рагхунатан
Матео Лени Сан
Роберт Т. Сариски
Николь Стовелл
Реймонд Свиит
Шанронг Зхао
Шизгонг Чен
Джилл Гилес-Комар
Кристен Пича
Ведрана Стоянович-Сусулик
Тереса Дж. Голетз
Original Assignee
Центокор, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Центокор, Инк. filed Critical Центокор, Инк.
Priority claimed from PCT/US2005/043373 external-priority patent/WO2006060513A2/en
Publication of UA97229C2 publication Critical patent/UA97229C2/en

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to an isolated monoclonal antibody that specifically binds to Toll Like Receptor 3 (TLR3) and inhibits cellular production of RANTES cytokine (Regulated on Activation, Normal T-cell Expressed and Secreted; chemokine isolated by T-cells on activation), a polynucleotide encoding the antibody, a vector, a host-cell, a hybridoma cell line and method of making the antibody. The invention further relates to a poharmaceutical composition comprising the antibody, a method of inhibiting cellular production of RANTES, a method of treating or preventing an inflammatory condition, a method of increasing the proliferation rate of a cell etc.
UAA200706796A 2004-11-30 2005-11-30 Isolated monoclonal antibody that specifically binds to toll like receptor 3 (tlr3) UA97229C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63181504P 2004-11-30 2004-11-30
PCT/US2005/043373 WO2006060513A2 (en) 2004-11-30 2005-11-30 Toll like receptor 3 antagonists, methods and uses

Publications (1)

Publication Number Publication Date
UA97229C2 true UA97229C2 (en) 2012-01-25

Family

ID=40595561

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200706796A UA97229C2 (en) 2004-11-30 2005-11-30 Isolated monoclonal antibody that specifically binds to toll like receptor 3 (tlr3)

Country Status (4)

Country Link
CN (1) CN101415438B (en)
SG (1) SG158098A1 (en)
UA (1) UA97229C2 (en)
ZA (1) ZA200705206B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ592542A (en) * 2008-10-31 2013-01-25 Centocor Ortho Biotech Inc Toll-like receptor 3 antagonists
IE20090514A1 (en) * 2009-07-06 2011-02-16 Opsona Therapeutics Ltd Humanised antibodies and uses therof
NZ622260A (en) * 2011-09-12 2016-11-25 Janssen Biotech Inc Toll-like receptor 3 antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152725A0 (en) * 2000-05-25 2003-06-24 Schering Corp Human receptor proteins, related reagents and methods

Also Published As

Publication number Publication date
SG158098A1 (en) 2010-01-29
ZA200705206B (en) 2009-01-28
CN101415438A (en) 2009-04-22
CN101415438B (en) 2013-03-27

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