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UA90013C2 - Фармацевтическая композиция, содержащая инсулин, и способ его получения - Google Patents

Фармацевтическая композиция, содержащая инсулин, и способ его получения

Info

Publication number
UA90013C2
UA90013C2 UAA200803496A UAA200803496A UA90013C2 UA 90013 C2 UA90013 C2 UA 90013C2 UA A200803496 A UAA200803496 A UA A200803496A UA A200803496 A UAA200803496 A UA A200803496A UA 90013 C2 UA90013 C2 UA 90013C2
Authority
UA
Ukraine
Prior art keywords
preparation
pharmaceutical composition
composition containing
containing insulin
insulin
Prior art date
Application number
UAA200803496A
Other languages
English (en)
Ukrainian (uk)
Inventor
Давид Анатолійович Нога
Павло Георгійович Матвєєв
Сєргєй Сєргєєвіч Маркін
Дмітрій Борісовіч Бєрєнштейн
Міхаіл Пєтровіч Сємьонов
Олександр Андрійович Тарасов
Ольга Маратовна ТАРАСОВА
Ігор В'ячеславович Рєдькін
Original Assignee
Давид Анатолійович Нога
Павло Георгійович Матвєєв
Сєргєй Сєргєєвіч Маркін
Дмітрій Борісовіч Бєрєнштейн
Міхаіл Пєтровіч Сємьонов
Олександр Андрійович Тарасов
Ольга Маратовна ТАРАСОВА
Ігор В'ячеславович Рєдькін
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Давид Анатолійович Нога, Павло Георгійович Матвєєв, Сєргєй Сєргєєвіч Маркін, Дмітрій Борісовіч Бєрєнштейн, Міхаіл Пєтровіч Сємьонов, Олександр Андрійович Тарасов, Ольга Маратовна ТАРАСОВА, Ігор В'ячеславович Рєдькін filed Critical Давид Анатолійович Нога
Priority to UAA200803496A priority Critical patent/UA90013C2/ru
Priority to CA2718915A priority patent/CA2718915A1/en
Priority to PCT/UA2008/000019 priority patent/WO2009116960A1/ru
Priority to EP08767349.7A priority patent/EP2266596B1/en
Priority to DK08767349.7T priority patent/DK2266596T3/da
Publication of UA90013C2 publication Critical patent/UA90013C2/ru
Priority to US12/883,984 priority patent/US20110064818A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к области получения лекарственных средств для лечения диабета и касается способа получения фармацевтической композиции, содержащей инсулин на полисахаридном носителе, который включает смешивание положительно заряженного золя хитозана с рН, равным 3,5-4,5 и отрицательно заряженного инсулина, который не содержит цинка, взят в виде коллоидного раствора или в виде наноразмерных кристаллических частичек. PН смешанного золя доводят до 5,5-6,5, проводят гелирование и обезвоживание геля с получением твердых частичек размером 10-100 мкм.
UAA200803496A 2008-03-19 2008-03-19 Фармацевтическая композиция, содержащая инсулин, и способ его получения UA90013C2 (ru)

Priority Applications (6)

Application Number Priority Date Filing Date Title
UAA200803496A UA90013C2 (ru) 2008-03-19 2008-03-19 Фармацевтическая композиция, содержащая инсулин, и способ его получения
CA2718915A CA2718915A1 (en) 2008-03-19 2008-03-25 Pharmaceutical composition and a method for the production thereof
PCT/UA2008/000019 WO2009116960A1 (ru) 2008-03-19 2008-03-25 Фармацевтическая композиция и способ её получения
EP08767349.7A EP2266596B1 (en) 2008-03-19 2008-03-25 Pharmaceutical composition and a method for the production thereof
DK08767349.7T DK2266596T3 (da) 2008-03-19 2008-03-25 Farmaceutisk sammensætning og fremgangsmåde til fremstilling deraf
US12/883,984 US20110064818A1 (en) 2008-03-19 2010-09-16 Pharmaceutical composition and a method for the production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UAA200803496A UA90013C2 (ru) 2008-03-19 2008-03-19 Фармацевтическая композиция, содержащая инсулин, и способ его получения

Publications (1)

Publication Number Publication Date
UA90013C2 true UA90013C2 (ru) 2010-03-25

Family

ID=41091167

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200803496A UA90013C2 (ru) 2008-03-19 2008-03-19 Фармацевтическая композиция, содержащая инсулин, и способ его получения

Country Status (6)

Country Link
US (1) US20110064818A1 (ru)
EP (1) EP2266596B1 (ru)
CA (1) CA2718915A1 (ru)
DK (1) DK2266596T3 (ru)
UA (1) UA90013C2 (ru)
WO (1) WO2009116960A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013164380A1 (en) * 2012-05-03 2013-11-07 Janssen R&D Ireland Polyinosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554388A (en) * 1989-02-25 1996-09-10 Danbiosyst Uk Limited Systemic drug delivery compositions comprising a polycationi substance
RU2175556C2 (ru) 1994-03-07 2001-11-10 Инхейл Терапьютик Системз Способы и композиции для легочной доставки инсулина
RU2066551C1 (ru) * 1994-03-23 1996-09-20 Институт нефтехимического синтеза РАН Способ получения инсулинсодержащих полимерных гидрогелей
BR9509171A (pt) * 1994-09-29 1997-09-16 Andaris Ltd Microparticulas secas por borrifamento como veículos terapêuticos
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
UA24452C2 (ru) 1998-01-09 2003-08-15 Закритоє Акціонєрноє Общество "Фосфосорб" Рекомбинантная плазмидная днк, кодирующая препроинсулин человека и штамм escherichia coli xl1 - blue / p insr- продуцент препроинсулина
RU2148642C1 (ru) 1998-12-23 2000-05-10 ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") Фрагмент днк rhtc, кодирующий синтез белка rhtc, придающего повышенную устойчивость к l-треонину бактериям escherichia coli, и способ получения l-аминокислоты
DE19940794A1 (de) 1999-08-27 2001-03-01 Lohmann Therapie Syst Lts Pharmazeutische Zubereitung
DE50108114D1 (de) 2000-12-13 2005-12-22 Merckle Gmbh Mikropartikel mit verbessertem freisetzungsprofil und verfahren zu deren herstellung
CA2433583A1 (en) 2001-07-05 2003-01-16 Translational Research Ltd. Composition of insulin for nasal administration
FI116625B (fi) * 2004-01-28 2006-01-13 Macrocrystal Oy Menetelmä proteiinien kiteyttämiseksi hiilihydraattirunkoisilla polymeereillä
ES2277743B2 (es) * 2005-06-02 2008-12-16 Universidade De Santiago De Compostela Nanoparticulas que comprenden quitosano y ciclodextrina.
WO2008028264A1 (en) * 2006-09-05 2008-03-13 Centro Brasileiro De Pesquisas Fisicas-Cbpf Process for the production of micro-capsules having magnetic properties, product obtained therefrom and method for the controlled release of active substances
RU2316339C1 (ru) 2006-09-13 2008-02-10 Общество С Ограниченной Ответственностью "Концерн О3" Способ получения препарата инсулина для перорального применения

Also Published As

Publication number Publication date
EP2266596A1 (en) 2010-12-29
CA2718915A1 (en) 2009-09-24
WO2009116960A1 (ru) 2009-09-24
EP2266596A4 (en) 2013-06-05
EP2266596B1 (en) 2014-07-02
DK2266596T3 (da) 2014-10-13
US20110064818A1 (en) 2011-03-17

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