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UA88771C2 - Proteasome inhibitors and methods of using the same (variants) - Google Patents

Proteasome inhibitors and methods of using the same (variants)

Info

Publication number
UA88771C2
UA88771C2 UAA200602694A UAA200602694A UA88771C2 UA 88771 C2 UA88771 C2 UA 88771C2 UA A200602694 A UAA200602694 A UA A200602694A UA A200602694 A UAA200602694 A UA A200602694A UA 88771 C2 UA88771 C2 UA 88771C2
Authority
UA
Ukraine
Prior art keywords
methods
variants
same
proteasome inhibitors
compositions
Prior art date
Application number
UAA200602694A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Альберто Бернареджи
Паоло Дж. Кассара
Шанкар Чаттерджи
Эдмондо Ферретти
Мохамед Икбал
Эрнесто Мента
Маклаугхлин Патрисия А. Мессина
Амброджио Олива
Джермано Дьаразмо
Мунари Серджио Де
Рафаэлла Бернардини
Original Assignee
Сефалон, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сефалон, Инк. filed Critical Сефалон, Инк.
Publication of UA88771C2 publication Critical patent/UA88771C2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
UAA200602694A 2003-08-14 2004-08-13 Proteasome inhibitors and methods of using the same (variants) UA88771C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49576403P 2003-08-14 2003-08-14

Publications (1)

Publication Number Publication Date
UA88771C2 true UA88771C2 (en) 2009-11-25

Family

ID=37426112

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200602694A UA88771C2 (en) 2003-08-14 2004-08-13 Proteasome inhibitors and methods of using the same (variants)

Country Status (7)

Country Link
CN (1) CN1867572B (en)
AR (2) AR045381A1 (en)
MY (1) MY162518A (en)
PE (1) PE20050360A1 (en)
TW (1) TWI345465B (en)
UA (1) UA88771C2 (en)
ZA (1) ZA200601293B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105837608B (en) * 2007-08-06 2018-06-08 米伦纽姆医药公司 Proteasome inhibitor and combinations thereof and purposes
CN102961387B (en) * 2007-08-06 2016-04-27 米伦纽姆医药公司 Proteasome inhibitor
SG10201508712QA (en) * 2007-08-06 2015-11-27 Millenium Pharmaceuticals Inc Proteasome inhibitors
SG194349A1 (en) * 2008-06-17 2013-11-29 Millennium Pharm Inc Boronate ester compounds and pharmaceutical compositions thereof
CN101638414B (en) * 2008-07-30 2014-01-08 江苏先声药物研究有限公司 Peptidyl boronic acid, ester compound thereof, preparation method of peptidyl boronic acid and ester compound thereof, and use of peptidyl boronic acid and ester compound thereof
AR075090A1 (en) * 2008-09-29 2011-03-09 Millennium Pharm Inc ACID DERIVATIVES 1-AMINO-2-CYCLLOBUTILETILBORONICO PROTEOSOMA INHIBITORS, USEFUL AS ANTI-BANKER AGENTS, AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM.
CN101747354B (en) * 2008-12-04 2014-08-13 江苏先声药物研究有限公司 Dipeptide boronic acids consisting of beta amino acids, ester compounds and preparation methods and uses thereof
EP2516449A1 (en) * 2009-12-22 2012-10-31 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
CA2794334C (en) * 2010-03-31 2018-06-12 Millennium Pharmaceuticals, Inc. Derivatives of 1-amino-2-cyclopropylethylboronic acid
CA2963203A1 (en) * 2014-10-01 2016-04-07 Merck Patent Gmbh Boronic acid derivatives
CN106588965A (en) 2015-10-15 2017-04-26 北京大学 Urea peptidomimetic boric acid compound as well as pharmaceutical composition, preparation method and application thereof
CN107400142B (en) * 2016-05-19 2019-11-19 成都奥璟生物科技有限公司 A kind of boric acid and boric acid ester compound and its application
US11154563B2 (en) * 2017-01-18 2021-10-26 Principia Biopharma Inc. Immunoproteasome inhibitors
CN108440583B (en) * 2017-01-23 2020-12-04 成都奥璟生物科技有限公司 Boric acid derivative and its medicinal composition
CN114437119B (en) * 2020-10-30 2024-08-09 苏州开拓药业股份有限公司 C-Myc protein inhibitor and preparation method and application thereof

Also Published As

Publication number Publication date
CN1867572B (en) 2012-03-28
CN1867572A (en) 2006-11-22
TWI345465B (en) 2011-07-21
PE20050360A1 (en) 2005-06-10
ZA200601293B (en) 2009-09-30
AR045381A1 (en) 2005-10-26
AR095249A2 (en) 2015-09-30
TW200529810A (en) 2005-09-16
MY162518A (en) 2017-06-15

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