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UA86605C2 - Антитело, которое содержит вариант исходного человеческого fс-участка - Google Patents

Антитело, которое содержит вариант исходного человеческого fс-участка

Info

Publication number
UA86605C2
UA86605C2 UAA200607634A UAA200607634A UA86605C2 UA 86605 C2 UA86605 C2 UA 86605C2 UA A200607634 A UAA200607634 A UA A200607634A UA A200607634 A UAA200607634 A UA A200607634A UA 86605 C2 UA86605 C2 UA 86605C2
Authority
UA
Ukraine
Prior art keywords
variant
region
polypeptides
novel
amino acid
Prior art date
Application number
UAA200607634A
Other languages
English (en)
Ukrainian (uk)
Inventor
Барретт В. Аллан
Дейвид Метью Маквис
Инь Тань
Джеффри Дин Уоткинс
Original Assignee
Аплайд Молекьюлер Иволюшн, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аплайд Молекьюлер Иволюшн, Инк. filed Critical Аплайд Молекьюлер Иволюшн, Инк.
Publication of UA86605C2 publication Critical patent/UA86605C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steering Control In Accordance With Driving Conditions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Изобретение относится к антителу, которое содержит вариант исходного Fc-участка иммуноглобулина человека или его часть, причем упомянутый вариант содержит, по меньшей мере, одну аминокислотную замену, сравнительно с исходным Fc-участком, и где указанной аминокислотной заменой является аминокислота в положении 247 последовательности человеческой Fc участка. Заявленное антитело опосредствует антителозависимую клеточноопосредованную цитотоксичность (ADCC) в присутствии эффекторных клеток с большей эффективностью, чем исходное антитело. Изобретение также относится к фармацевтической композиции, которая содержит антитело с аминокислотной заменой в положении 247 Fc участка иммуноглобулина человека.
UAA200607634A 2004-01-12 2005-01-10 Антитело, которое содержит вариант исходного человеческого fс-участка UA86605C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53576404P 2004-01-12 2004-01-12

Publications (1)

Publication Number Publication Date
UA86605C2 true UA86605C2 (ru) 2009-05-12

Family

ID=34806962

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200607634A UA86605C2 (ru) 2004-01-12 2005-01-10 Антитело, которое содержит вариант исходного человеческого fс-участка

Country Status (21)

Country Link
US (1) US20080089892A1 (ru)
EP (2) EP1706424B1 (ru)
JP (1) JP4762156B2 (ru)
KR (1) KR101149242B1 (ru)
CN (1) CN1918178B (ru)
AT (1) ATE437184T1 (ru)
AU (1) AU2005206473B2 (ru)
BR (1) BRPI0506771A (ru)
CA (1) CA2552788C (ru)
CY (1) CY1109382T1 (ru)
DE (1) DE602005015542D1 (ru)
DK (1) DK1706424T3 (ru)
EA (1) EA009746B1 (ru)
ES (1) ES2328369T3 (ru)
IL (1) IL176674A (ru)
NO (1) NO339745B1 (ru)
PL (1) PL1706424T3 (ru)
PT (1) PT1706424E (ru)
SI (1) SI1706424T1 (ru)
UA (1) UA86605C2 (ru)
WO (1) WO2005070963A1 (ru)

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