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UA81664C2 - Производные дифенилмочевины и их применение, как блокаторов хлоридных каналов - Google Patents

Производные дифенилмочевины и их применение, как блокаторов хлоридных каналов

Info

Publication number
UA81664C2
UA81664C2 UAA200510477A UAA200510477A UA81664C2 UA 81664 C2 UA81664 C2 UA 81664C2 UA A200510477 A UAA200510477 A UA A200510477A UA A200510477 A UAA200510477 A UA A200510477A UA 81664 C2 UA81664 C2 UA 81664C2
Authority
UA
Ukraine
Prior art keywords
heading
channel blockers
chloride channel
normal
diphenylurea derivatives
Prior art date
Application number
UAA200510477A
Other languages
English (en)
Ukrainian (uk)
Inventor
Бьярне Г. Даль
Палле Кристоферсен
Original Assignee
Ньюросерч А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ньюросерч А/С filed Critical Ньюросерч А/С
Publication of UA81664C2 publication Critical patent/UA81664C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Заявленное изобретение касается новых производных дифенилмочевины, полезных как блокаторы хлоридных каналов. В других аспектах изобретение касается применения этих соединений в способе терапии и фармацевтических композициях, которые содержат соединения изобретения.
UAA200510477A 2003-06-17 2004-06-15 Производные дифенилмочевины и их применение, как блокаторов хлоридных каналов UA81664C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200300898 2003-06-17
PCT/EP2004/051111 WO2004111017A1 (en) 2003-06-17 2004-06-15 Diphenylurea derivatives and their use as chloride channel blockers

Publications (1)

Publication Number Publication Date
UA81664C2 true UA81664C2 (ru) 2008-01-25

Family

ID=33547538

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200510477A UA81664C2 (ru) 2003-06-17 2004-06-15 Производные дифенилмочевины и их применение, как блокаторов хлоридных каналов

Country Status (20)

Country Link
US (1) US7691891B2 (ru)
EP (1) EP1638948B1 (ru)
JP (1) JP2006527735A (ru)
KR (1) KR20060059901A (ru)
CN (1) CN1805942B (ru)
AT (1) ATE411301T1 (ru)
AU (1) AU2004247429B2 (ru)
BR (1) BRPI0410576A (ru)
CA (1) CA2529806A1 (ru)
DE (1) DE602004017175D1 (ru)
DK (1) DK1638948T3 (ru)
HK (1) HK1091816A1 (ru)
IS (1) IS8211A (ru)
MX (1) MXPA05013269A (ru)
NO (1) NO20060231L (ru)
NZ (1) NZ543595A (ru)
RU (1) RU2350607C2 (ru)
UA (1) UA81664C2 (ru)
WO (1) WO2004111017A1 (ru)
ZA (1) ZA200508828B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007007029A (es) * 2004-12-17 2007-08-08 Neurosearch As Derivados de difenilurea utiles como activadores del canal de potasio.
KR20080103106A (ko) 2006-03-14 2008-11-26 뉴로서치 에이/에스 디페닐우레아 유도체 및 클로라이드 채널 차단제 또는 ＢＫＣａ 채널 조정자로서의 이의 용도
WO2009068557A1 (en) * 2007-11-28 2009-06-04 Neurosearch A/S Novel phenyl-acetamide and phenyl-propionamide derivatives useful as potassium channel modulators
US9834537B2 (en) 2013-11-27 2017-12-05 Korea Institute Of Science And Technology Compounds as chloride channel blocking agent
BR112018073518A2 (pt) * 2016-05-17 2019-03-19 Scandion Oncology A/S métodos para sensibilização de células de câncer a um tratamento anticâncer, para potencialização do efeito terapêutico de um tratamento anticâncer e para tratamento de câncer, composição, modulador de canais de ânion regulados por volume, kit de peças, e, uso de um modulador de canais de ânion regulados por volume
CN117229258B (zh) * 2022-06-07 2024-07-19 杭州壹瑞医药科技有限公司 N-四唑基芳基脲类衍生物及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69716424T2 (de) * 1996-05-24 2003-02-20 Neurosearch A/S, Ballerup Saure gruppen enthaltende phenylderivate, ihre herstellung und ihre verwendung als chloridkanalblocker
CZ295822B6 (cs) 1997-04-22 2005-11-16 Neurosearch A/S Substituované fenylderiváty, způsob jejich přípravy a použití a farmaceutické přípravky s jejich obsahem
US6696475B2 (en) * 1997-04-22 2004-02-24 Neurosearch A/S Substituted phenyl derivatives, their preparation and use
EP1117633B1 (en) 1998-10-02 2002-09-18 Neurosearch A/S Diaminocyclobutene-3,4-dione derivatives, their preparation and use
AP2001002103A0 (en) * 1998-10-22 2001-03-31 Neurosearch As Substituted phenyl derivatives, their preparation and use.
AU2002223492A1 (en) * 2000-11-14 2002-05-27 Neurosearch A/S Use of malaria parasite anion channel blockers for treating malaria
US20050080112A1 (en) * 2001-06-22 2005-04-14 Madsen Lars Siim Compounds for use in disorders associated with mast cell or basophil acitvity
WO2004012733A2 (en) * 2002-08-01 2004-02-12 Neurosearch A/S Compounds useful for the treatment of diseases responsive to antiangiogenetic therapy
MXPA05002493A (es) 2002-09-05 2005-05-27 Neurosearch As Derivados de diarilurea y su uso como bloqueadores del canal del cloro.
MX2007007029A (es) * 2004-12-17 2007-08-08 Neurosearch As Derivados de difenilurea utiles como activadores del canal de potasio.

Also Published As

Publication number Publication date
JP2006527735A (ja) 2006-12-07
IS8211A (is) 2005-12-30
NO20060231L (no) 2006-01-16
US7691891B2 (en) 2010-04-06
CA2529806A1 (en) 2004-12-23
DE602004017175D1 (de) 2008-11-27
US20060178413A1 (en) 2006-08-10
KR20060059901A (ko) 2006-06-02
MXPA05013269A (es) 2006-03-17
HK1091816A1 (en) 2007-01-26
NZ543595A (en) 2009-01-31
BRPI0410576A (pt) 2006-06-20
RU2005136532A (ru) 2006-07-27
EP1638948A1 (en) 2006-03-29
EP1638948B1 (en) 2008-10-15
DK1638948T3 (da) 2009-02-02
CN1805942B (zh) 2010-06-02
ZA200508828B (en) 2008-01-30
CN1805942A (zh) 2006-07-19
RU2350607C2 (ru) 2009-03-27
AU2004247429B2 (en) 2010-01-28
WO2004111017A1 (en) 2004-12-23
AU2004247429A1 (en) 2004-12-23
ATE411301T1 (de) 2008-10-15

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