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UA66793C2 - Лептин як стримувач швидкого збільшення пухлини клітини - Google Patents

Лептин як стримувач швидкого збільшення пухлини клітини

Info

Publication number
UA66793C2
UA66793C2 UA99116415A UA99116415A UA66793C2 UA 66793 C2 UA66793 C2 UA 66793C2 UA 99116415 A UA99116415 A UA 99116415A UA 99116415 A UA99116415 A UA 99116415A UA 66793 C2 UA66793 C2 UA 66793C2
Authority
UA
Ukraine
Prior art keywords
leptin
inhibitor
tumor growth
oncology
disclosed
Prior art date
Application number
UA99116415A
Other languages
English (en)
Russian (ru)
Inventor
Даліт Баркан
Батя Кохен
Меначем Рубінштейн
Original Assignee
Йєда Рісерч Енд Дівелопмент Ко. Лтд
Йеда Рисерч Энд Дивелопмент Ко. Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Йєда Рісерч Енд Дівелопмент Ко. Лтд, Йеда Рисерч Энд Дивелопмент Ко. Лтд. filed Critical Йєда Рісерч Енд Дівелопмент Ко. Лтд
Publication of UA66793C2 publication Critical patent/UA66793C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Розкрито застосування лептину і молекул, споріднених лептину, в онкології.
UA99116415A 1997-04-29 1998-04-26 Лептин як стримувач швидкого збільшення пухлини клітини UA66793C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12073397A IL120733A0 (en) 1997-04-29 1997-04-29 Leptin as an inhibitor of cell proliferation
PCT/IL1998/000196 WO1998048831A1 (en) 1997-04-29 1998-04-26 Leptin as an inhibitor of tumor cell proliferation

Publications (1)

Publication Number Publication Date
UA66793C2 true UA66793C2 (uk) 2004-06-15

Family

ID=11070075

Family Applications (1)

Application Number Title Priority Date Filing Date
UA99116415A UA66793C2 (uk) 1997-04-29 1998-04-26 Лептин як стримувач швидкого збільшення пухлини клітини

Country Status (26)

Country Link
US (1) US7109159B1 (uk)
EP (1) EP0981365B1 (uk)
JP (1) JP4330662B2 (uk)
KR (1) KR100507731B1 (uk)
CN (1) CN1168497C (uk)
AR (1) AR012626A1 (uk)
AT (1) ATE283702T1 (uk)
AU (1) AU742927B2 (uk)
BG (1) BG63490B1 (uk)
CA (1) CA2288238A1 (uk)
CZ (1) CZ299872B6 (uk)
DE (1) DE69827942T2 (uk)
EA (1) EA002353B1 (uk)
EE (1) EE04801B1 (uk)
ES (1) ES2232944T3 (uk)
HK (1) HK1028350A1 (uk)
HU (1) HUP0002427A3 (uk)
IL (2) IL120733A0 (uk)
NO (1) NO322304B1 (uk)
NZ (1) NZ500589A (uk)
PL (1) PL195275B1 (uk)
PT (1) PT981365E (uk)
SK (1) SK284848B6 (uk)
UA (1) UA66793C2 (uk)
WO (1) WO1998048831A1 (uk)
ZA (1) ZA983608B (uk)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208572B2 (en) 1998-08-21 2007-04-24 Albany Medical College Leptin-related peptides
US6777388B1 (en) 1998-08-21 2004-08-17 Clf Medical Technology Acceleration Program, Inc. Leptin-related peptides
US20050272652A1 (en) 1999-03-29 2005-12-08 Gault Victor A Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
IL132312A0 (en) * 1999-09-05 2001-03-19 Yeda Res & Dev Use of leptin in inhibition of endothelial cell proliferation
IN2012DN03921A (uk) 2004-02-11 2015-09-04 Amylin Pharmaceuticals Inc
US8076288B2 (en) 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
US7863240B2 (en) * 2004-10-08 2011-01-04 Enzo Therapeutics, Inc. Methods and uses of leptin in hepatocellular carcinoma
US8969291B2 (en) 2004-10-08 2015-03-03 Enzo Therapeutics, Inc. Methods for decreasing leptin levels or activity for treating inflammation
WO2007022123A2 (en) 2005-08-11 2007-02-22 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
EA011653B1 (ru) 2005-02-11 2009-04-28 Амилин Фармасьютикалз, Инк. Аналоги и гибридные полипептиды gip с избираемыми свойствами
US8263545B2 (en) 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
EP2330125A3 (en) 2005-08-11 2012-12-12 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
US8227408B2 (en) * 2005-09-07 2012-07-24 Neurotez, Inc. Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
US8497240B2 (en) 2006-08-17 2013-07-30 Amylin Pharmaceuticals, Llc DPP-IV resistant GIP hybrid polypeptides with selectable properties
US9938333B2 (en) * 2008-02-08 2018-04-10 Ambrx, Inc. Modified leptin polypeptides and their uses
CN102099048A (zh) * 2008-05-21 2011-06-15 纽若泰兹公司 用于治疗与神经原纤维缠结有关的进行性认知障碍的方法
AU2009313562B2 (en) * 2008-11-04 2012-11-15 Neurotez, Inc. Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amlyoid beta
US20100316639A1 (en) 2009-06-16 2010-12-16 Genentech, Inc. Biomarkers for igf-1r inhibitor therapy
TW202417497A (zh) 2015-10-12 2024-05-01 美商再生元醫藥公司 活化瘦素受體的抗原結合蛋白
SG10201913470SA (en) 2016-11-08 2020-03-30 Regeneron Pharma Antigen-binding proteins that antagonize leptin receptor
SG11202005146VA (en) 2017-12-18 2020-06-29 Regeneron Pharma Bispecific antigen binding molecules that bind leptin receptor and/or gp130, and methods of use thereof
CA3094400A1 (en) 2018-04-06 2019-10-10 Regeneron Pharmaceuticals, Inc. A leptin receptor agonist antibody for use in treating a metabolic dysfunction or hypoleptinemia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL324284A1 (en) * 1995-06-30 1998-05-11 Lilly Co Eli Methods of treating diabetes
CA2232193A1 (en) * 1995-09-19 1997-03-27 Brigitte Elisabeth Schoner Dna encoding medicinal proteins
ES2260784T3 (es) * 1996-01-23 2006-11-01 Indevus Pharmaceuticals, Inc. Metodos de utilizacion del gen obese y su producto genico para estimular el desarrolo hematopoyetico.

Also Published As

Publication number Publication date
EP0981365B1 (en) 2004-12-01
DE69827942D1 (de) 2005-01-05
CZ384899A3 (cs) 2000-06-14
PL336582A1 (en) 2000-07-03
BG63490B1 (bg) 2002-03-29
IL120733A0 (en) 1997-08-14
NO322304B1 (no) 2006-09-11
AR012626A1 (es) 2000-11-08
AU742927B2 (en) 2002-01-17
PL195275B1 (pl) 2007-08-31
EP0981365A1 (en) 2000-03-01
BG103832A (en) 2000-10-31
NO995267L (no) 1999-12-28
CN1261802A (zh) 2000-08-02
CA2288238A1 (en) 1998-11-05
IL132633A (en) 2007-07-04
ES2232944T3 (es) 2005-06-01
NZ500589A (en) 2001-03-30
CZ299872B6 (cs) 2008-12-17
SK147199A3 (en) 2000-06-12
KR20010012080A (ko) 2001-02-15
HUP0002427A3 (en) 2003-02-28
EA199900981A1 (ru) 2000-04-24
PT981365E (pt) 2005-03-31
EA002353B1 (ru) 2002-04-25
US7109159B1 (en) 2006-09-19
DE69827942T2 (de) 2005-12-08
ZA983608B (en) 1998-11-02
SK284848B6 (sk) 2006-01-05
EE9900510A (et) 2000-06-15
CN1168497C (zh) 2004-09-29
WO1998048831A1 (en) 1998-11-05
JP4330662B2 (ja) 2009-09-16
EE04801B1 (et) 2007-04-16
NO995267D0 (no) 1999-10-28
HUP0002427A2 (hu) 2000-12-28
HK1028350A1 (en) 2001-02-16
JP2001524968A (ja) 2001-12-04
ATE283702T1 (de) 2004-12-15
KR100507731B1 (ko) 2005-08-10
AU7076298A (en) 1998-11-24

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