UA64934A - Complex antibacterial sorption preparation benegol for preventing anaerobic infection and treating purulent wounds, neurepathic eschar, and wounds and method for its manufacture - Google Patents

Abstract

The complex antibacterial sorption preparation Benegol for preventing the anaerobic infection and treating the purulent wounds, the neurepathic eschar, and the wounds represents the siliceous sorbent aerosil with the immobilized sodium permanganate (èînO4). The mixture actively inhibits the anaerobic pathogenic bacteria, purifies the surface of the wound, decreases the hypoxia, improves blood supply, eliminates the putrid smell, and possesses the analgetic and antiedematous activity. The composition of the mixture in mass % is such as follows: aerosil 49.2 - 98.0 sodium permanganate 2.0 - 50.8.

Description

The invention relates to new substances based on highly dispersed fumed silica - Aerosil (pharmaceutical trade name Sillard P), containing potassium permanganate (KMpOz4) immobilized on it. Such a mixture actively suppresses anaerobic and aerobic pathogenic microorganisms, cleans the surface of the wound, improves blood supply to tissues, reduces hypoxia, eliminates the unpleasant putrid smell, especially in the case of anaerobic infection, has an anesthetic and anti-edematous effect.

Known commercial drugs used for the treatment of wound anaerobic infection, for example, derivatives of nitroimidazole (metronidazole, tinidazole), dioxidin, clindamycin. Anaerobic gram-positive cocci, Vas.tadiiiih, Vas.teIaptodepisiv, and others are sensitive to them (1). Among domestic drugs, nitazol (2-acetylamino-5-nitrothiazole) is very effective in anaerobic infection, which, in addition, shows activity against spore-forming anaerobes (clostridia) (21.

However, all of them do not show an antihypoxic effect, do not have a prolonged effect and therefore do not give a lasting effect in the treatment of anaerobic infection, which in current medical practice is the cause of most complications, which often leads to a fatal outcome in case of wounds, peritonitis. The closest in terms of technical essence and therapeutic action is the drug "Imosgent", which is a composition that contains a xerogel of methylsilicic acid with the antibiotic gentamicin I4Y immobilized on it. This drug has a prolonged antimicrobial effect on pathogenic aerobic microorganisms and is effective for the treatment of burns and purulent wounds. At the same time, this drug also has insufficient effectiveness in the treatment of anaerobic and gram-positive infections, does not improve tissue blood supply, and does not show an antihypoxic effect. In addition, most microorganisms have developed acquired resistance to the main active ingredient of the drug, gentamicin, which makes the drug ineffective in many cases.

The drug Imosgent is prepared by impregnating a xerogel of methylsilicic acid with a solution of gentamicin followed by drying the composition at temperatures below 502C to prevent the deactivation of the antimicrobial action of the active component - the antibiotic gentamicin |41.

The purpose of this invention is a composition based on highly dispersed fumed silica - Aerosil (pharmaceutical trade name Sillard P) and immobilized on it potassium permanganate (КМпО»54). for the treatment of aerobic and anaerobic infection, which would have an increased preventive and curative effect, cleanse the wound surface, improve tissue blood supply, eliminate the unpleasant putrid smell, especially in anaerobic infection, have an anesthetic and anti-edematous effect, as well as the method of its preparation.

The set goal is achieved by the fact that the composition (Benegol), which includes highly dispersed pyrogenic silica - Aerosil (trade pharmaceutical name Sillard P), contains potassium permanganate (KMpoOx) immobilized on it with the following composition of components in mass.9o:

Aerosil from 49.2 to 98.0

KMpog from 2.0 to 50.8

Such a composition was not known before.

Aerosil is a highly dispersed pyrogenic silica consisting of hydrated spherical particles with an average radius of 4.35 nm, an airgel of polysilicate acid with a composition of 5iOg"xHgO, the water content can reach 1Omas.9b.

Aerosil is approved for oral use as an enterosorbent and as a matrix for the immobilization of drugs.

The composition is prepared in the following way: 1) preparation of a solution of potassium permanganate from 0.2 to 9% by weight; 2) mixing Aerosil powder with permanganate solution, which are taken in appropriate quantities; 3) maturation of the mixture at a temperature of 15-2570 for 20-30 minutes; 4) drying the mixture at a temperature of 90-1007C until a dry loose powder is formed.

Below are examples of specific preparation of Benegol.

Example 1. "Benegol 1" Add 100 ml of 0.295% potassium permanganate solution (KMpokhm) to 10 g of aerosol (Sylard P). The mixture was stirred for 15 minutes until a homogeneous substance was formed and left to mature for 20 minutes at a temperature of 420°C. The resulting mixture was transferred to a glass plate or a Petri dish and dried at a temperature of -90-1007C in a drying cabinet until a dry loose pink powder was formed .

The resulting powdery preparation was transferred to a glass jar with a capacity of 25 ml and tightly closed with a polyethylene lid.

The yield of the drug is 10.2 g. It is used for the treatment of burns of the second stage of superficial wounds, trophic ulcers, does not cause pain.

Example 2. "Benegol 1" Add 20 ml of 0.595% potassium permanganate solution (KMpoOx) to 2 g of aerosol (Sylard P). The mixture was stirred for 10 minutes until a homogeneous substance was formed and left to mature for 30 minutes at a temperature of 420°C. The resulting mixture was transferred to a glass plate or a Petri dish and dried at a temperature of 90-1007°C in an oven until a dry loose powder of violet color was formed.

The resulting powdery preparation was transferred to a glass jar with a capacity of 10 ml and tightly closed with a polyethylene lid.

The yield of the drug is 2.1 g.

It is used for the treatment of second-stage burns, superficial wounds, trophic ulcers, does not cause pain.

Example 3. "Benegol 1" Add 100 ml of a 1.095% solution of potassium permanganate (KMpokhm) to 9.0 g of aerosol (Sylard P). The mixture was stirred for 15 minutes until a homogeneous substance was formed and left to mature for 30 minutes at a temperature of -20"C. The resulting mixture was transferred to a glass dish or a Petri dish and dried at a temperature of -90-1007"C in a drying cabinet until a dry loose powder was formed. dark purple powder.

The resulting powdery preparation was transferred to a glass jar with a capacity of 25 ml and tightly closed with a polyethylene lid.

The output of the drug is 10.Og.

It is used for the treatment of second-stage burns, superficial wounds, trophic ulcers, does not cause pain.

Example 4. "Benegol 2" Add 8 Oml of 2.095% potassium permanganate solution (KMpokhm) to 8.0 g of aerosol (Sylard P). The mixture was stirred for 20 minutes until a homogeneous substance was formed and left to ripen for 20 minutes at a temperature of 423"C. The resulting mixture was transferred to a glass plate or a Petri dish and dried at a temperature of -90-1007"C in a drying cabinet until a dry loose powder was formed dark purple color.

The resulting powdery preparation was transferred to a glass jar with a capacity of 25 ml and tightly closed with a polyethylene lid.

The output of the drug is 10.Og.

It is used for the treatment of second-stage burns, superficial wounds, trophic ulcers, does not cause pain.

Example 5. "Benegol 2" Add 52 ml of a 5.095% solution of potassium permanganate (KMpo»m) to 5.0 g of aerosol (Sylard P). The mixture was stirred for 20 minutes until a homogeneous substance was formed and left to mature for 30 minutes at a temperature of 425°C. The resulting mixture was transferred to a glass plate or a Petri dish and dried at a temperature of -90-1007°C in a drying cabinet until a dry loose powder was formed. dark purple color.

The resulting powdery preparation was transferred to a glass jar with a capacity of 10 ml and tightly closed with a polyethylene lid.

The output of the drug is 7, bg.

They are used for the treatment of very purulent wounds, burns of the PI-IM stages of necrotic trophic ulcers. Destroys the smell, cleans the wound from pus, necrotic tissues.

Example 6. "Benegol 2" Add 52 ml of a 10.095% solution of potassium permanganate (KMpokhm) to 5.0 g of aerosol (Sylard P). The mixture was stirred for 20 minutes until a homogeneous substance was formed and left to ripen for 30 minutes at a temperature of 20"C. The resulting mixture was transferred to a glass dish or a Petri dish and dried at a temperature of -90-1007"C in a drying cabinet until a dry loose powder was formed. dark purple color.

The resulting powdery preparation was transferred to a glass jar with a capacity of 25 ml and tightly closed with a polyethylene lid.

The output of the drug is 10.Og.

They are used for the treatment of very purulent wounds, burns of the PI-IM stages of necrotic trophic ulcers. Destroys the smell, cleans the wound from pus, necrotic tissues.

Method of obtaining

Benegol I synonyms (Agnosil Y) 5g. Azrosyla (Sillard P, Polysorb) is poured with 50 ml of a solution of 0.2 g of potassium permanganate (KMpoh) and the resulting porridge-like mass is thoroughly mixed, left to ripen at room temperature for 20-30 minutes, and then dried at 100-110"C for 12 hours to the formation of a dry loose powder of a dark violet color.

Benegol 2 synonyms: (Agnosil 2) 5 g. Azrosyla (Sillard P, Polysorb) is poured into 50 ml of a solution containing 1 g of potassium permanganate (KMp4) and the resulting porridge-like mass is thoroughly mixed, left to mature at room temperature for 20-30 minutes, and then dried at 100-110" for 12 hours until a dry loose powder of dark violet color.

We have established that for the preparation of the drug "Benegol 1", which is used for the treatment of burns of the second stage of superficial wounds, trophic ulcers, solutions of no more than 195 potassium permanganate (KMpoOx4) can be used. For "Benegol 2", which is used for the treatment of very purulent wounds, burns of the PI-II stages of necrotic trophic ulcers - no more than 1095 potassium permanganate solution (KMpOd). "Benegol 1" was used in 21 patients with superficial trophic ulcers, burns of the 1st stage, purulent wounds in the stage of granulation, "BENEGOL 2" was used in 12 patients with purulent wounds in the stage of necrosis, gangrene in diabetes, trophic ulcers with necrosis, etc.

Example: Patient M., born in 1938, was hospitalized for chronic venous insufficiency of the lower extremities, complicated by a trophic ulcer, covered in places with necrotic tissue. V. Egadiyev5, E. Soii 107 in 1 year were obtained during microbiological research. fabrics After two bandages with benegol 1, no microbes were obtained, the ulcer completely healed in 8 days.

Example 2: Patient V., born in 1956, hospitalized for a huge phlegmon of the perineal-scrotal area - Fournier's phlegmon. The patient's condition was very severe, severe intoxication, body temperature 39-40"C, putrid smell, the entire surface of the skin in the specified area was necrotized. Surgical intervention was performed. Benegol 2 was applied to the wound surface. After 2 hours, the unpleasant smell disappeared, the temperature decreased. Gradually the patient's condition improved, Benegol 2 was repeatedly applied to the wound. Recovery.

In connection with the above, the new drug Benegol 1 and Benegol 2 can be used for the prevention and local treatment of aerobic and anaerobic infections in wounds of various genesis, trophic ulcers, abscesses, etc.

Literature. 1. Blatun L.A., Yakovlev V.P. Contemporary aspects of general and local antibacterial therapy of anaserobic infection of soft tissues // Tez. acc. All-Union symposium "Anaerobic non-clostridial infection in purulent surgery. - Ternopil - 1989. - P.6-8. 2. Afinogenov G.E., Elinov I.P. - Antiseptics in surgery. - L..: Medicine. - 1987 - 144 p.; M. D. Mashkovsky,

Medicines - Kharkiv, Izd. Torsing - 1997. - 1 volume p. 268.

Z. Znamensky V.A. and others. Use of therapeutic and prophylactic drugs made on the basis of organosilicon adsorbents. Methodological recommendations. - K.: UGROTStsaANDYSY. - 1992. - 166. 4. Shalimov A.A. etc. The method of treatment of purulent wounds // As. USSR Me1144699 with priority from 11/15/1984 (prototype).

Claims (2)

1. A complex antimicrobial sorption preparation for the prevention of anaerobic infection and the treatment of purulent wounds, trophic ulcers and burns, which is a silica sorbent with a drug immobilized on it, which differs in that aerosol is used as a sorbent, and potassium is used as a drug immobilized on it permanganate (KMpoO»x) with the following composition of components, wt. 90: Aerosil (Sillard P, Polysorb) 49.2 - 98.0 potassium permanganate (KMpoOzh) 2.0 - 50.8. 2. The method of obtaining a complex antimicrobial sorption preparation, which differs in that 0.2 to 10.0 wt.% is added to the aerosol powder with thorough mixing. 95 of a solution of potassium permanganate (KMpoh), mix 10 g of powder and from 80 to 100 g of a solution in a solvent indifferent to potassium permanganate (KMpOx), with a content of potassium permanganate (KMpoh) from 0.2 to 10.0 g, until a homogeneous substance is obtained , keep the obtained substance for ripening at a temperature from 15 to 30 "C for 20 - 30 minutes, followed by drying at a temperature from 90 to 1007C.