Харківський Ордена Леніна Політехнічний Інститут Ім. В.І. Леніна
Харьковский Ордена Ленина Политехнический Институт Им. В.И. Ленина
Івано-Франківська Фірма "Барва"
Ивано-Франковская фирма "Барва"
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Priority to UA3676317ApriorityCriticalpatent/UA5795A1/en
Publication of UA5795A1publicationCriticalpatent/UA5795A1/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
A process for the preparation of 4-e-oxyethylsulfonyl-aniline sulphate involves reduction of N-substituted p-aminobenzene sulphochloride with sodium sulphite at temperature of 30-35°C in alkaline medium followed by hydroxyethylation with chloroethanol of corresponding sulphinic acid at heating and pH of 6.9-7 with further use of hydrolysis stages in the presence of mineral acid at heating and esterification with concentrated sulphuric acid at heating of the prepared N-substituted 4-4-oxyethylsulfonyl-aniline. In order to simplify the process and to increase the yield of desired product p-carbomethoxybenzene sulphochloride is used as N-substituted p-aminobenzene sulphochloride, and reduction is carried out at pH of 9-10, hydroxyethylation is carried out at temperature of 80-97°C and the prepared N-carbomethoxy-4-4-oxyethylsulfonyl-aniline is subjected to hydrolysis in the presence of concentrated chlorine hydride.
UA3676317A1983-11-041983-11-04Process for the preparation of 4-?-oxyethylsulfonyl?aniline sulphate
UA5795A1
(en)