UA12840A1 - METHOD OF OBTAINING RIGHT-ROTARY OXYISOIDOLIDICH DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTED SALTS - Google Patents
METHOD OF OBTAINING RIGHT-ROTARY OXYISOIDOLIDICH DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTED SALTSInfo
- Publication number
- UA12840A1 UA12840A1 UA4355276A UA4355276A UA12840A1 UA 12840 A1 UA12840 A1 UA 12840A1 UA 4355276 A UA4355276 A UA 4355276A UA 4355276 A UA4355276 A UA 4355276A UA 12840 A1 UA12840 A1 UA 12840A1
- Authority
- UA
- Ukraine
- Prior art keywords
- derivatives
- oxyisoidolidich
- rotary
- pharmaceutically accepted
- accepted salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Способ получения правовращающих производных оксиизоиндолинила или их фармацевтически приемлемых солей включает взаимодействие с о-фталевым ангидридом с последующим восстановлением полученного при этом соединения с использованием стадии разделения рацемата на оптические изомеры. Соединения в виде рацемата предварительно подвергаются разделению на оптические изомеры и взаимодействие о-фталевого ангидрида проводится с правовращающим изомером соединения с последующим восстановлением оптически активного соединения и выделением целевого продукта в свободном виде или в виде фармацевтически приемлемой соли.The method of obtaining dextrorotatory derivatives of oxyisoindolinyl or their pharmaceutically acceptable salts includes interaction with o-phthalic anhydride, followed by reduction of the resulting compound using the stage of separation of the racemate into optical isomers. Compounds in the form of a racemate are preliminarily subjected to separation into optical isomers and the reaction of o-phthalic anhydride is carried out with the dextrorotatory isomer of the compound, followed by reduction of the optically active compound and isolation of the target product in free form or in the form of a pharmaceutically acceptable salt.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878705601A GB8705601D0 (en) | 1987-03-10 | 1987-03-10 | Oxo-isoindolinyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA12840A1 true UA12840A1 (en) | 1997-02-28 |
Family
ID=10613660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA4355276A UA12840A1 (en) | 1987-03-10 | 1988-03-09 | METHOD OF OBTAINING RIGHT-ROTARY OXYISOIDOLIDICH DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTED SALTS |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPH0759555B2 (en) |
| KR (1) | KR880011096A (en) |
| CN (1) | CN1017527B (en) |
| AT (1) | AT392068B (en) |
| AU (1) | AU605253B2 (en) |
| BE (1) | BE1003280A3 (en) |
| CH (1) | CH675419A5 (en) |
| DE (1) | DE3807595A1 (en) |
| DK (1) | DK168568B1 (en) |
| ES (1) | ES2006361A6 (en) |
| FI (1) | FI93725C (en) |
| FR (1) | FR2612185B1 (en) |
| GB (2) | GB8705601D0 (en) |
| GR (1) | GR1000515B (en) |
| HU (1) | HU201011B (en) |
| IE (1) | IE60565B1 (en) |
| IL (1) | IL85651A (en) |
| IT (1) | IT1227787B (en) |
| MY (1) | MY103898A (en) |
| NL (1) | NL8800575A (en) |
| NO (1) | NO174666C (en) |
| NZ (1) | NZ223805A (en) |
| PH (1) | PH26254A (en) |
| PT (1) | PT86933B (en) |
| SE (1) | SE500710C2 (en) |
| SU (1) | SU1731046A3 (en) |
| UA (1) | UA12840A1 (en) |
| YU (1) | YU46565B (en) |
| ZA (1) | ZA881686B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5272158A (en) * | 1991-10-29 | 1993-12-21 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| IT1256450B (en) * | 1992-11-26 | 1995-12-05 | Soldato Piero Del | NITRIC ESTERS WITH PHARMACOLOGICAL ACTIVITY AND PROCEDURE FOR THEIR PREPARATION |
| US5719144A (en) * | 1995-02-22 | 1998-02-17 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| US5981584A (en) * | 1997-02-06 | 1999-11-09 | Merck & Co., Inc. | Fibrinogen receptor antagonist prodrugs |
| CN100400633C (en) * | 2006-03-30 | 2008-07-09 | 中国日用化学工业研究院 | A kind of hand dishwashing detergent and preparation method thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2154525A1 (en) * | 1970-11-05 | 1972-06-15 | Carlo Erba S.P.A., Mailand (Italien) | Isoindoline derivatives and processes for their preparation |
| GB1344663A (en) * | 1970-11-10 | 1974-01-23 | Erba Carlo Spa | Isoindoline compounds |
| US4010274A (en) | 1973-07-27 | 1977-03-01 | Carlo Erba | Isoindoline derivatives having platelet anti-aggregating activity |
| JPS516959A (en) * | 1974-07-04 | 1976-01-20 | Wakamoto Pharma Co Ltd | Isoindorinjudotaino seizohoho |
| US4400520A (en) * | 1980-09-10 | 1983-08-23 | Hisamitsu Pharmaceutical Co., Inc. | Novel process for preparing isoindoline derivatives |
| IT1201408B (en) * | 1985-03-22 | 1989-02-02 | Montedison Spa | PROCESS FOR THE BIOTECHNOLOGICAL PREPARATION OF OPTICALLY ACTIVE ALFA-ARILALCANOIC ACIDS |
| JPH07120969B2 (en) * | 1989-03-30 | 1995-12-20 | クラリオン株式会社 | Spread spectrum modulator |
-
1987
- 1987-03-10 GB GB878705601A patent/GB8705601D0/en active Pending
-
1988
- 1988-02-22 PH PH46539A patent/PH26254A/en unknown
- 1988-03-04 CH CH826/88A patent/CH675419A5/de not_active IP Right Cessation
- 1988-03-07 AT AT0058988A patent/AT392068B/en not_active IP Right Cessation
- 1988-03-07 AU AU12679/88A patent/AU605253B2/en not_active Ceased
- 1988-03-07 FR FR888802872A patent/FR2612185B1/en not_active Expired - Lifetime
- 1988-03-07 IL IL85651A patent/IL85651A/en not_active IP Right Cessation
- 1988-03-08 HU HU881124A patent/HU201011B/en not_active IP Right Cessation
- 1988-03-08 YU YU46788A patent/YU46565B/en unknown
- 1988-03-08 NL NL8800575A patent/NL8800575A/en not_active Application Discontinuation
- 1988-03-08 ES ES8800684A patent/ES2006361A6/en not_active Expired
- 1988-03-08 GR GR880100137A patent/GR1000515B/en unknown
- 1988-03-08 DE DE3807595A patent/DE3807595A1/en not_active Withdrawn
- 1988-03-08 KR KR1019880002373A patent/KR880011096A/en not_active Application Discontinuation
- 1988-03-08 IT IT8819683A patent/IT1227787B/en active
- 1988-03-09 ZA ZA881686A patent/ZA881686B/en unknown
- 1988-03-09 JP JP63055954A patent/JPH0759555B2/en not_active Expired - Lifetime
- 1988-03-09 DK DK128988A patent/DK168568B1/en not_active IP Right Cessation
- 1988-03-09 SE SE8800846A patent/SE500710C2/en unknown
- 1988-03-09 GB GB8805631A patent/GB2204579B/en not_active Expired - Lifetime
- 1988-03-09 NO NO881055A patent/NO174666C/en unknown
- 1988-03-09 BE BE8800258A patent/BE1003280A3/en not_active IP Right Cessation
- 1988-03-09 NZ NZ223805A patent/NZ223805A/en unknown
- 1988-03-09 UA UA4355276A patent/UA12840A1/en unknown
- 1988-03-09 PT PT86933A patent/PT86933B/en not_active IP Right Cessation
- 1988-03-09 FI FI881075A patent/FI93725C/en not_active IP Right Cessation
- 1988-03-09 CN CN88101200A patent/CN1017527B/en not_active Expired
- 1988-03-09 SU SU884355276A patent/SU1731046A3/en active
- 1988-03-10 MY MYPI88000246A patent/MY103898A/en unknown
- 1988-08-07 IE IE64888A patent/IE60565B1/en not_active IP Right Cessation
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