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UA127575C2 - Проліки на основі катехоламіну для застосування в лікуванні нейродегенеративного захворювання - Google Patents

Проліки на основі катехоламіну для застосування в лікуванні нейродегенеративного захворювання

Info

Publication number
UA127575C2
UA127575C2 UAA202003060A UAA202003060A UA127575C2 UA 127575 C2 UA127575 C2 UA 127575C2 UA A202003060 A UAA202003060 A UA A202003060A UA A202003060 A UAA202003060 A UA A202003060A UA 127575 C2 UA127575 C2 UA 127575C2
Authority
UA
Ukraine
Prior art keywords
substituent
compounds
disease
treatment
parkinson
Prior art date
Application number
UAA202003060A
Other languages
English (en)
Inventor
Клаус Ґерві Єнсен
Клаус Герви ЕНСЕН
Лісбет Квєрньо
Лисбет Кверньо
Мартін Юхль
Мартин Юхль
Мортен Йорґенсен
Мортен Йоргенсен
Original Assignee
Х. Луннбек А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Луннбек А/С filed Critical Х. Луннбек А/С
Publication of UA127575C2 publication Critical patent/UA127575C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Даним винаходом передбачені сполуки формули (I), які являють собою проліки на основі катехоламіну для застосування в лікуванні нейродегенеративних захворювань і порушень. Даним винаходом також передбачені фармацевтичні композиції, які містять сполуки даного винаходу, і способи лікування нейродегенеративних або нейропсихіатричних захворювань і порушень із застосуванням сполук цього винаходу, зокрема хвороби Паркінсона. Відповідно, даний винахід належить до сполук формули (Id) , (Id) де R1 являє собою H і R2 вибраний з одного із замісників (i) і (ii), зазначених нижче; або R1 вибраний з одного із замісників (i) і (ii), зазначених нижче, і R2 являє собою H; або R1 і R2 одночасно представлені замісником (i), зазначеним нижче; або R1 і R2 одночасно представлені замісником (ii), зазначеним нижче; або R1 являє собою замісник (i) і R2 являє собою замісник (ii); або R1 являє собою замісник (ii) і R2 являє собою замісник (i); , (i) , (ii) де * позначає точку приєднання; і при цьому атом вуглецю в точці приєднання при заміснику (i) знаходиться в S-конфігурації; або їх фармацевтично прийнятної солі.
UAA202003060A 2017-11-24 2018-11-23 Проліки на основі катехоламіну для застосування в лікуванні нейродегенеративного захворювання UA127575C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201700674 2017-11-24
PCT/EP2018/082361 WO2019101917A1 (en) 2017-11-24 2018-11-23 New catecholamine prodrugs for use in the treatment of parkinson's disease

Publications (1)

Publication Number Publication Date
UA127575C2 true UA127575C2 (uk) 2023-10-18

Family

ID=64661284

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA202003060A UA127575C2 (uk) 2017-11-24 2018-11-23 Проліки на основі катехоламіну для застосування в лікуванні нейродегенеративного захворювання

Country Status (25)

Country Link
US (4) US10729710B2 (uk)
EP (1) EP3713933A1 (uk)
JP (4) JP7320507B2 (uk)
KR (1) KR102712887B1 (uk)
CN (3) CN117653649A (uk)
AR (1) AR113908A1 (uk)
AU (2) AU2018371193B2 (uk)
BR (1) BR112019014981A2 (uk)
CA (1) CA3082757A1 (uk)
CL (1) CL2020001343A1 (uk)
CO (1) CO2020006224A2 (uk)
CR (1) CR20200225A (uk)
EA (1) EA202090987A8 (uk)
EC (1) ECSP20030074A (uk)
GE (1) GEP20227446B (uk)
IL (1) IL274648B2 (uk)
JO (1) JOP20200114A1 (uk)
MA (1) MA50800A (uk)
MX (2) MX2020005366A (uk)
PE (1) PE20211290A1 (uk)
PH (1) PH12020550631A1 (uk)
SG (1) SG11202004461YA (uk)
TW (1) TWI816716B (uk)
UA (1) UA127575C2 (uk)
WO (1) WO2019101917A1 (uk)

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JP2023552699A (ja) 2020-11-17 2023-12-19 ハー・ルンドベック・アクチエゼルスカベット パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ
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SG11202004461YA (en) 2020-06-29
PH12020550631A1 (en) 2021-02-22
IL274648B2 (en) 2024-10-01
AU2018371193B2 (en) 2022-12-22
EA202090987A8 (ru) 2020-09-29
CL2020001343A1 (es) 2020-09-25
JOP20200114A1 (ar) 2020-05-17
EP3713933A1 (en) 2020-09-30
US20240156851A1 (en) 2024-05-16
CN111386267A (zh) 2020-07-07
JP7320684B2 (ja) 2023-08-03
JP2023145580A (ja) 2023-10-11
US20220257623A1 (en) 2022-08-18
AU2023201741A1 (en) 2023-04-20
US20200338102A1 (en) 2020-10-29
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