UA102016C2 - Short-chain peptides as parathyroid hormone (pth) receptor agonist - Google Patents
Short-chain peptides as parathyroid hormone (pth) receptor agonistInfo
- Publication number
- UA102016C2 UA102016C2 UAA201111810A UAA201111810A UA102016C2 UA 102016 C2 UA102016 C2 UA 102016C2 UA A201111810 A UAA201111810 A UA A201111810A UA A201111810 A UAA201111810 A UA A201111810A UA 102016 C2 UA102016 C2 UA 102016C2
- Authority
- UA
- Ukraine
- Prior art keywords
- short
- chain peptides
- pth
- receptor agonist
- parathyroid hormone
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 102000003982 Parathyroid hormone Human genes 0.000 title abstract 2
- 108090000445 Parathyroid hormone Proteins 0.000 title abstract 2
- 239000000199 parathyroid hormone Substances 0.000 title abstract 2
- 229960001319 parathyroid hormone Drugs 0.000 title abstract 2
- 239000000018 receptor agonist Substances 0.000 title abstract 2
- 229940044601 receptor agonist Drugs 0.000 title abstract 2
- 210000000988 bone and bone Anatomy 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 2
- 208000000038 Hypoparathyroidism Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 102000057297 Pepsin A Human genes 0.000 abstract 1
- 108090000284 Pepsin A Proteins 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000001853 liver microsome Anatomy 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 229940111202 pepsin Drugs 0.000 abstract 1
- 208000001685 postmenopausal osteoporosis Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000006337 proteolytic cleavage Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention provides novel short-chain peptides, which primarily act as parathyroid hormone (PTII/ PTH-I) receptor agonist. These short-chain peptides exhibit increased stability to proteolytic cleavage. Most of short-chain peptides were found to be stable in rat plasma up to 24 hours (in vitro), showed increased stability against GIT enzymes such as pepsin and acidic stomach pH and also against liver microsomes (in vitro). Due to increased metabolic stability, other than parenteral route of administration, some of the short-chain peptides can also be delivered by oral routes of administration, for the treatment/prevention of hypoparathyroidism and diseases characterized by bone mass reduction, such as osteoporosis, postmenopausal osteoporosis and for stimulating bone repair. A-Z-Z-Z-Z-Z-Z-Z-Z-Z-Z-Z-Z-Z-Z-Z-B (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1095MU2009 | 2009-04-24 | ||
| PCT/IN2010/000264 WO2010128521A2 (en) | 2009-04-24 | 2010-04-26 | Short-chain peptides as parathyroid hormone (pth) receptor agonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA102016C2 true UA102016C2 (en) | 2013-05-27 |
Family
ID=51949555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201111810A UA102016C2 (en) | 2009-04-24 | 2010-04-26 | Short-chain peptides as parathyroid hormone (pth) receptor agonist |
Country Status (1)
| Country | Link |
|---|---|
| UA (1) | UA102016C2 (en) |
-
2010
- 2010-04-26 UA UAA201111810A patent/UA102016C2/en unknown
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