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UA100545C2 - Гидроксилированные пиримидил циклопентаны как ингибиторы протеинкиназы акт - Google Patents

Гидроксилированные пиримидил циклопентаны как ингибиторы протеинкиназы акт

Info

Publication number
UA100545C2
UA100545C2 UAA201009871A UAA201009871A UA100545C2 UA 100545 C2 UA100545 C2 UA 100545C2 UA A201009871 A UAA201009871 A UA A201009871A UA A201009871 A UAA201009871 A UA A201009871A UA 100545 C2 UA100545 C2 UA 100545C2
Authority
UA
Ukraine
Prior art keywords
protein kinase
kinase inhibitors
akt protein
hydroxylated
pyrimidyl cyclopentanes
Prior art date
Application number
UAA201009871A
Other languages
English (en)
Ukrainian (uk)
Inventor
Джозеф Р. Бенсік
Джеймс Ф. Блейк
Ніколас С. Каллан
Ян С. Мітчелл
Кейт Лі Спенсер
Денгмінг Хіао
Руі Ху
Крістін Чабот
Стівен До
Джун Ліанг
Браян Сафіна
Біронг Жанг
Original Assignee
Еррей Біофарма Інк.
Дженентек, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Еррей Біофарма Інк., Дженентек, Інк. filed Critical Еррей Біофарма Інк.
Publication of UA100545C2 publication Critical patent/UA100545C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Данное изобретение описывает соединения, в том числе их фармацевтически приемлемые соли, которые соответствуют Формуле I: I, а также применение соединений согласно изобретению как ингибиторов протеинкиназы АКТ, а также для лечения гиперпролиферативных заболеваний, таких как рак.
UAA201009871A 2008-01-09 2009-09-01 Гидроксилированные пиримидил циклопентаны как ингибиторы протеинкиназы акт UA100545C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2009208P 2008-01-09 2008-01-09
PCT/US2009/030610 WO2009089459A1 (en) 2008-01-09 2009-01-09 Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors

Publications (1)

Publication Number Publication Date
UA100545C2 true UA100545C2 (ru) 2013-01-10

Family

ID=40552865

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201009871A UA100545C2 (ru) 2008-01-09 2009-09-01 Гидроксилированные пиримидил циклопентаны как ингибиторы протеинкиназы акт

Country Status (18)

Country Link
US (1) US8835434B2 (ru)
EP (1) EP2247578B1 (ru)
JP (1) JP5346345B2 (ru)
KR (1) KR101624753B1 (ru)
CN (1) CN101932564B (ru)
AU (1) AU2009204025B2 (ru)
BR (1) BRPI0906798A2 (ru)
CA (1) CA2711699A1 (ru)
CR (1) CR11601A (ru)
EC (1) ECSP10010389A (ru)
ES (1) ES2422733T3 (ru)
IL (1) IL206575A0 (ru)
MA (1) MA32183B1 (ru)
NZ (1) NZ586346A (ru)
RU (1) RU2504542C2 (ru)
UA (1) UA100545C2 (ru)
WO (1) WO2009089459A1 (ru)
ZA (1) ZA201004769B (ru)

Families Citing this family (9)

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WO2009089352A1 (en) 2008-01-08 2009-07-16 Array Biopharma Inc. Pyrrolopyridines as kinase inhibitors
CN104876921A (zh) 2008-01-09 2015-09-02 阵列生物制药公司 作为AKT蛋白激酶抑制剂的5H-环戊二烯并[d]嘧啶
US8372842B2 (en) 2008-01-09 2013-02-12 Array Biopharma Inc. Pyrazolopyridines as kinase inhibitors
CN104487430B (zh) 2012-05-17 2016-08-24 阵列生物制药公司 用于制造羟基化的环戊基嘧啶化合物的方法
RU2650511C2 (ru) * 2012-05-17 2018-04-16 Дженентек, Инк. Формы и составы пиримидинилциклопентанового соединения, композиции и способы, относящиеся к ним
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Also Published As

Publication number Publication date
RU2010132911A (ru) 2012-02-20
IL206575A0 (en) 2010-12-30
NZ586346A (en) 2012-02-24
MA32183B1 (fr) 2011-04-01
BRPI0906798A2 (pt) 2015-07-14
WO2009089459A1 (en) 2009-07-16
RU2504542C2 (ru) 2014-01-20
ZA201004769B (en) 2011-12-28
ECSP10010389A (es) 2010-11-30
CN101932564B (zh) 2012-12-26
EP2247578B1 (en) 2013-05-22
KR20100118110A (ko) 2010-11-04
KR101624753B1 (ko) 2016-05-26
AU2009204025B2 (en) 2014-02-20
US8835434B2 (en) 2014-09-16
AU2009204025A1 (en) 2009-07-16
JP5346345B2 (ja) 2013-11-20
ES2422733T3 (es) 2013-09-13
CA2711699A1 (en) 2009-07-16
EP2247578A1 (en) 2010-11-10
CR11601A (es) 2010-08-19
CN101932564A (zh) 2010-12-29
JP2011509308A (ja) 2011-03-24
US20110065716A1 (en) 2011-03-17

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