TWI850131B - Signal sensing device with assembly structure and biodegradable signal sensing device thereof - Google Patents

Abstract

A signal sensing device, having a corresponding assembly structure, is adapted for installing the signal sensing device to a to-be-detected target object conveniently. The device comprises a body and a signal sensing element. The body has an assembly structure. The assembly structure has a first assembly portion and a second assembly portion spaced apart from each other on the body. The signal sensing element has a signal transmitting segment and a signal sensing segment electrically connecting with each other and provided in the body. In a situation that a partial part of the body forms an encircle portion embracing a to-be-detected target object, the first assembly portion and a second assembly portion are aligned to each other, and a partial part or an entire part of the signal sensing segment forms the encircle portion. The proposed signal sensing device provides the effect of conveniently assembling signal sensing device to the to-be-detected target object.

Description

Signal detection device with assembly structure and biodegradable signal detection device

The present invention relates to a signal detection device, in particular to a signal detection device with an assembly structure and a biodegradable signal detection device.

In the process of measuring related signals by surrounding the target object, especially when installing a signal detection device for measuring physiological signals in a biological body, due to the lack of technical means to conveniently install the signal detection device, the corresponding installation method is difficult to operate, or the corresponding assembly structure of the signal detection device is complicated.

In view of this, the conventional signal detection device still needs to be improved.

In order to solve the above problems, the purpose of the present invention is to provide a signal detection device that can be easily installed on the target object to be detected.

The second purpose of the present invention is to provide a signal detection device that can be installed in a living body and degraded over time and absorbed by the living body.

The directions or similar terms described in the present invention, such as "front", "rear", "left", "right", "top", "bottom", "inside", "outside", "side", "radial", "axial", "length direction", "width direction", etc., are mainly for reference to the directions of the attached drawings. Each direction or similar terms are only used to assist in the description and understanding of the various embodiments of the present invention, and are not used to limit the present invention.

The quantifiers "one" or "a" used in the components and parts described in the present invention are only for the convenience of use and to provide a general meaning of the scope of the present invention; they should be interpreted in the present invention as including one or at least one, and the single concept also includes the plural case, unless it is obvious that it means otherwise.

The definitions of the dimensional specifications described in the entire text of the present invention are based on Figure 1 of the present invention. The "length" is defined along the extension direction of the length of the head or extension of the body (such as the label _LH or _LE ), that is, the extension direction of the reference axis Y in Figure 3; the "width" is defined along the extension direction of the width of the head or extension of the body (such as the label _WH or _WE ), that is, the extension direction of the reference axis X in Figure 3; the "thickness" (which can also represent the height) is defined along the extension direction of the thickness of the head or extension of the body (such as the label _TH or _TE ), that is, the extension direction of the reference axis Z in Figure 3. In addition, the size adjustment of all dimensional specifications mentioned in the present invention can be adjusted in intervals of 0.1μm. In addition, the frequency adjustment of the "operating frequency" described in the present invention can be adjusted within a range of 1 MHz. In addition, all specific values mentioned in the present invention can have an allowable error range of plus or minus 10%.

A signal detection device of the present invention comprises: a body having an assembly structure, wherein the assembly structure has a first assembly part and a second assembly part which are arranged on the body at intervals; a signal detection element having a signal transmission section and a signal sensing section which are electrically connected to each other and are arranged inside the body; and a fixing member, wherein in a case where a part of the body forms a surrounding part and surrounds a target object to be detected, the first assembly part and the second assembly part are aligned with each other, and the fixing member is inserted into the first assembly part and the second assembly part which are aligned with each other, so that the fixing member is combined with the first assembly part and the second assembly part to maintain the shape of the surrounding part; a part or all of the signal sensing section is located in the surrounding part.

Accordingly, the signal transmission element of the present invention can be aligned with each other through the first assembly part and the second assembly part of the assembly structure, and can then be conveniently and easily combined with the assembly structure by the fixing member, so as to achieve the effect of simply and conveniently installing the signal detection device on the target object to be detected.

The signal detection device further includes a signal amplifier, which has a plurality of protruding structures protruding outward from the main body; the protruding structure is cylindrical, has a diameter between 250 and 400 mm, preferably between 300 and 350 μm, and has a height between 40 and 75 μm, preferably 50 μm; in the case where the surrounding part is formed on a part of the main body, the signal amplifier is partially or completely in contact with the target to be detected. Thus, through the configuration of the above-mentioned specific shape and size of the protruding structure, when the signal detection device is used to surround the target to be detected for signal detection, the effect of greatly improving the intensity of the sensing signal can be achieved.

The first assembly part and the second assembly part each have at least one through hole; the fixing part has a connecting part, an inserting part and a buckle part; the inserting part extends outward from the connecting part; the buckle part protrudes outward from a position of the inserting part; in a case where the fixing part is combined with the first assembly part and the second assembly part, the inserting part extends through the through holes of the first assembly part and the second assembly part that are aligned with each other, the connecting part is located on one side of one of the first assembly part and the second assembly part, and the buckle part is clamped on one side of the other of the first assembly part and the second assembly part. In this way, through the configuration of the fixing part and the assembly structure, the fixing part and the assembly structure can have the effect of simple structure, and the signal detection device can be fixed to the target object to be detected.

Each of the through holes has a through hole diameter in the radial direction; the buckle portion has an entry end and a buckle end, the entry end is located at an end facing away from the connecting portion, and the buckle end is located between the connecting portion and the entry end; the entry end is formed into a shape with a gradual expansion toward the buckle end, so that the length of the buckle portion in the radial direction gradually increases along an axial direction. In this way, through the gradual expansion configuration of the buckle portion of the fixing member in shape, the effect of easily combining with the assembly structure can be achieved, and the effect of making the fixing member and the assembly structure have a stable combination can be achieved.

The first assembly part and the second assembly part each have two through-holes, and the insertion part of the fixing part forms two protruding structures corresponding to the number of the through-holes, so that the fixing part has a U-shaped or V-shaped shape as a whole. In this way, through the assembly structure, when the number of through-holes used for assembly is two and the fixing part has a corresponding number of insertion parts, compared with the case where the number of through-holes and insertion parts is only one, the force between the fixing part and the assembly structure can be made more uniform, and the stability of the combination between the fixing part and the assembly structure can be improved. In addition, compared with the case where the number of through-holes and insertion parts is more than two, the space utilization efficiency of the overall structure in miniaturization can be improved, and the shapes of the fixing part and the assembly structure are simpler, so that the manufacturing is simple and cost-saving can be achieved.

The main body also has a plurality of marking features, each of which is arranged on the main body to align the first assembly part with the second assembly part. In this way, the convenience of alignment during installation of the assembly structure can be improved.

Among them, each of the marking features is a triangular notch, and a vertex of the triangular notch is aligned with the first assembly part and the second assembly. In this way, the convenience of alignment during installation of the assembly structure can be improved.

Each of the marking features is a linear mark. In this way, the convenience of alignment during installation of the assembly structure can be improved.

The present invention provides a biodegradable signal detection device, wherein the signal detection device is made of one or more biodegradable materials.

Accordingly, the biodegradable signal transmission element of the present invention, through the signal detection device made of biodegradable materials, can be installed in the body to detect the signal of interest, and completely degrade within a predetermined period of time without further surgery to remove it, thereby achieving the effect of avoiding the risk of another surgery.

1: Body

1H: Head

1E: Extension

1W: Surrounding part

11: Assembly structure

11A: First assembly department

11B: Second assembly section

2:Signal detection element

2a: Signal transmission segment

2b: Signal sensing section

3: Signal amplifier

31: Protruding structure

4: Fixing parts

41: Connection part

42: Insertion part

43: Buckle part

43a:Entry port

43b: snap-on end

L _H , _LE : Length

M: Signature feature

T: Target object to be tested

_TH , _TE :Thickness

W _H , _WE :Width

X,Y,Z: reference axis

[Figure 1] A three-dimensional schematic diagram of a preferred embodiment of the signal detection device of the present invention.

[Figure 2] A schematic diagram showing the signal detection device in Figure 1 surrounding the target object to be detected.

[Figure 3] A schematic diagram showing the signal detection device in Figure 2 being fixed to the target object to be detected.

[Figure 4] A schematic cross-sectional view along the A-A direction as shown in Figure 3.

[Figure 5] Another implementation of the marking feature of the signal detection device of the present invention.

[Figure 6] A partial enlarged view of the signal amplifier shown in Figure 1.

[Figure 7] Schematic diagram of the signal characteristics of a venous blood vessel measured by the signal detection device of the present invention.

In order to make the above and other purposes, features and advantages of the present invention more clearly understood, the following specifically cites the preferred embodiments of the present invention and provides a detailed description in conjunction with the attached drawings; in addition, the same symbols in different drawings are considered the same and their descriptions will be omitted.

Please refer to Figures 1 and 2, which respectively show a signal detection device of a preferred embodiment of the present invention and an example of a target object to be detected. The signal detection device has a body and a signal detection element 2. A portion of the body 1 forms a surrounding portion for surrounding a target object T to be detected, and the signal detection element 2 is disposed inside the body 1. Preferably, the target object T to be detected is a structure such as an organ or tissue of a biological body. It should be noted that the target object T to be detected shown in Figure 2 is a blood vessel, but the target object T to be detected is not limited to a blood vessel.

Optionally, the signal detection device has another signal amplifier 3 disposed on the body 1, so that when the body 1 partially surrounds the target object T to be detected, the entire or a part of the signal amplifier 3 is in contact with the target object T to be detected.

The body 1 is used to cover the signal detection element 2 to protect the signal detection element 2 and reduce the interference of the detection environment on the signal detection element 2. Optionally, the body 1 is formed into a long sheet configuration, and preferably surrounds the target T to be detected with a wider area. Optionally, the body 1 is formed into a long sheet configuration with uniform size; for example, in the length direction, the width and thickness are respectively maintained consistent. Optionally, as shown in Figures 1 and 2, the main body 1 is formed into a long sheet having a head 1H and an extension 1E connected to each other, and the extension 1E extends outward from one end of the head 1H to a length so as to surround the target object T to be detected through all or part of the extension 1E; in particular, a surrounding portion 1W is formed by a part of the extension 1E to surround the target object T to be detected. When the extension 1E forms the surrounding portion 1W, a free end of the extension 1E or a portion close to the free end can be fixed to an appropriate position of the extension 1E itself, so that the main body 1 can stably surround the target object T to be detected; the fixing method of the extension 1E can be selected according to the actual situation, and the present invention is not limited thereto.

As shown in FIG. 1 , there is at least one signal detection element 2 , each having a signal transmission segment 2a and a signal sensing segment 2b electrically connected to each other, and disposed inside the main body 1 ; as shown in FIG. 2 , in a case where a portion of the main body 1 forms a surrounding portion 1W surrounding the target object T to be detected, a portion or all of the signal sensing segment 2b is located within the surrounding portion 1W. In detail, the signal transmission section 2a is located at the head 1H of the body 1, and may have a configuration such as an antenna structure, so as to convert a sensing signal generated by the signal sensing section 2b, especially a sensing signal generated by the target object T to be detected, into a transmission signal (such as an electromagnetic wave) having a specific working frequency and send it out; in particular, send it to a signal analysis device (not shown), which converts the transmission signal into corresponding information to be monitored, so as to perform relevant analysis or monitoring management. The signal sensing segment 2b is located at the extension portion 1E of the main body 1, and extends and is distributed in the area of the main body 1 to surround the target object T to be measured, so as to receive information to be monitored (such as blood flow rate) in the target object T to be measured (such as a blood vessel), and convert the information to be monitored into a sensing signal (such as an electrical signal); then, the sensing signal is transmitted to the signal transmission segment 2a through the signal sensing segment 2b, so as to generate a corresponding transmission signal through the signal transmission segment 2a. In detail, the transmission signal can be transmitted to a corresponding receiving unit (not shown), and the receiving unit can analyze the received transmission signal according to a predetermined method to convert the transmission signal into the monitoring information of the target object T to be detected, so as to observe, analyze or monitor the changes of the monitoring information.

Preferably, the antenna structure is a flat antenna (Flat Antenna/Planar Antenna) configuration; the operating frequency can be determined by the antenna pattern/shape (Antenna Pattern) of the signal transmission segment 2a; in other words, different operating frequencies can be obtained through different antenna patterns under the same material and scale; the antenna pattern can be, for example, composed of at least one of a square loop, a circular loop, a triangular loop, an asymmetric loop, and other patterns. According to the research of the present invention, when the signal detection device of the present invention is placed in the human body, the operating frequency has a better transmission effect between 350MHz and 450MHz; more preferably, the operating frequency is between 401MHz and 406MHz. In this way, within the operating frequency range, the signal transmission segment 2a can transmit signals with stable signal quality.

Optionally, as shown in FIG. 1 , the main body 1 has an assembly structure 11, the assembly structure 11 has a first assembly part 11A and a second assembly part 11B, the number of the first assembly part 11A and the number of the second assembly part 11B are at least one, and the first assembly part 11A and the second assembly part 11B are spaced apart from each other; in particular, when the number of either the first assembly part 11A or the second assembly part 11B is plural, the multiple assembly parts (the first assembly part 11A and/or the second assembly part 11B) are spaced apart from each other. Preferably, the first assembly part 11A and the second assembly part 11B are arranged on the extension part 1E of the main body 1, and the first assembly part 11A is arranged at a position closer to the free end of the extension part 1E than the second assembly part 11B.

As shown in Figures 2 and 3, when the main body 1 forms a ring (for example, by bending), especially when the main body 1 forms the ring to surround the target object T to be measured, the first assembly part 11A and the second assembly part 11B are configured to be aligned with each other, especially to overlap and contact each other; at this time, in order to ensure that the first assembly part 11A and the second assembly part 11B maintain the configuration of being aligned with each other and make the main body 1 surround and/or be fixed to the target object T to be measured, a fixing member 4 is combined with the first assembly part 11A and the second assembly part 11B to maintain the shape of the surrounding part 1W. In detail, the combination refers to the structure between the fixing member 4, the first assembly part 11A and the second assembly part 11B having mutually matching concave features or convex features, and is achieved by, for example, using one or more of snap-fit, structural tension and flexibility between the combined features.

Optionally, the first assembly portion 11A and the second assembly portion 11B each have at least one through hole. The fixing member 4 has a connecting portion 41, an inserting portion 42 and a buckle portion 43. The inserting portion 42 extends outward from the connecting portion 41 and has a free end. The free end is far away from the connecting portion 41. The buckle portion 43 protrudes outward from a position of the inserting portion 42 and is spaced a distance from the connecting portion 41; preferably, the buckle portion 43 protrudes from the free end of the inserting portion 42. In a case where the fixing member 4 is combined with the first assembly part 11A and the second assembly part 11B, the insertion part 42 extends through the through holes of the first assembly part 11A and the second assembly part 11B that are aligned with each other, the connecting part 41 is located on one side of the first assembly part 11A and the second assembly part 11B, and the buckle part 43 is clamped on one side of the other of the first assembly part 11A and the second assembly part 11B.

In detail, as shown in FIGS. 3 and 4, corresponding to the radial direction (such as the plane direction formed by the reference axes X and Y) and the axial direction (such as the extension direction of the reference axis Z), each of the through holes has a through hole diameter in the radial direction; the connecting portion 41 is located on the outer side of the assembly structure 11 and protrudes from the through hole in the radial direction, so that when the fixing member 4 is combined with the assembly structure 11, the connecting portion 41 of the fixing member 4 will not pass through the through hole, but is located on one side of the assembly structure 11 (i.e., on one side of the first assembly part 11A and the second assembly part 11B). The insertion portion 42 extends in the axial direction, and its shape or contour in the axial direction can pass through the through holes of the assembly structure 11. The buckle portion 43 has an entry end 43a and a buckle end 43b. The entry end 43a is located at an end facing away from the connecting portion 41, and the buckle end 43b is located between the connecting portion 41 and the entry end 43a. When the fixing member 4 is combined with the assembly structure 11, the buckle end 43b of the buckle portion 43 is clamped against the other side of the assembly structure 11.

Preferably, the entry end 43a is formed into a shape with a gradual expansion toward the buckle end 43b, so that the radial length of the buckle portion 43 gradually increases along the axial direction. In this way, the entry end 43a of the buckle portion 43 is easily inserted and passed through the overlapping and aligned through-hole formed by the first assembly portion 11A and the second assembly portion 11B, and after the buckle portion 43 passes through the through-hole, the buckle end 43b protrudes from the through-hole in the radial direction. Thus, after the buckle portion 43 passes through the through hole, the connection portion 41 is located on one side of the assembly structure 11, and the buckle end 43b is clamped against the other side of the assembly structure 11, and the connection portion 41 and the buckle end 43b protrude from the through hole in the radial direction respectively, so that the first assembly portion 11A and the second assembly portion 11B can be inseparable, thereby ensuring that the signal detection device of the present invention can be fixedly surrounded on the target object T to be detected.

According to the above description of the assembly structure 11 and the fixing member 4, in the present invention, the number of the through-holes can be one or more, and the number, position and shape of the through-holes of the first assembly part 11A and the through-holes of the second assembly part 11B are designed to be aligned with each other; and corresponding to the arrangement of the through-holes, the fixing member 4 also has an insertion portion 42 arranged accordingly. In a preferred embodiment of the present invention, as shown in Figures 1 to 4, the first assembly part 11A and the second assembly part 11B each have two through-holes, and the insertion portion 42 of the fixing member 4 forms two protrusion structures corresponding to the number of the through-holes, so that the fixing member 4 has a U-shaped or V-shaped shape as a whole. It should be noted that although the number of the through holes of the first assembly part 11A and the second assembly part 11B shown in the diagram of the present invention is two respectively, it is not limited to this.

Optionally, as shown in Figures 1 to 3, the body 1 may have a plurality of marked features M, each of which is arranged on the body 1 to align with the first assembly part 11A and the second assembly part 11B to mark/indicate the positions of the first assembly part 11A and the second assembly part 11B; each of the marked features M is a notch, preferably a triangular notch, and more preferably a vertex of the triangle is aligned with the first assembly part 11A and the second assembly part 11B.

Optionally, as shown in FIG. 5 , each marking feature M is a linear mark (Line-type Mark), preferably a straight-line mark (Straight-line Mark), and optionally extends to the side of the main body 1 or is only arranged on the side of the main body 1, so that when the first assembly part 11A and the second assembly part 11B are aligned, the straight-line marks of the first assembly part 11A and the second assembly part 11B are connected to form a straight line on the side of the main body 1. The side of the body 1 refers to at least one of the two opposite sides in the width direction, or at least one of the two opposite sides on the reference axis X as shown in FIG. 3, or in the case where the body 1 forms the surrounding portion 1W, at least one of the two axially opposite sides of the surrounding portion 1W; in particular, each of the marking features M used for alignment is located on the same side of the body 1.

By means of the above-mentioned marking feature M, when the marking feature M on the first assembly part 11A and the second assembly part 11B are aligned, for example, when the notches overlap (as shown in Figures 1 to 3) or when the linear marks are arranged in a specific pattern (as shown in Figure 5), it means that the first assembly part 11A and the second assembly part 11B have been aligned, so that when the user installs the signal detection device of the present invention on a target object T to be detected, the marking feature M can be used to more easily align the first assembly part 11A and the second assembly part 11B to fix the body 1 on the target object T to be detected.

It should be noted that the marking feature M is a mark that is visually different from the main body 1 (especially different from the main body 1 and the target object T to be detected), such as any one or any combination of color, text, symbol, pattern, mark and structural configuration (such as protrusion or notch), forming an indicative or distinguishable feature; therefore, the form of the marking feature M is not limited to the above-mentioned notch (such as Figures 1 to 3) and linear mark (such as Figure 5).

In an embodiment of the signal detection device having the signal amplifying part 3, as shown in FIGS. 1, 2 and 6, the signal amplifying part 3 has a plurality of protruding structures 31, and is protrudingly disposed on an outer side of the body 1, and the plurality of protruding structures 31 protrude outward from the outer side of the body 1 to form a plurality of protruding shapes; in a case where a part of the body 1 forms a surrounding part 1W surrounding the target object T to be detected, a part or all of the signal amplifying part 3 is located in the surrounding part 1W, and the signal amplifying part 3 is partially or completely in contact with the target object T to be detected. In detail, when the signal detection device of the present invention is placed on a plane and unfolded as shown in FIG. 1, the plurality of protruding structures 31 protrude from the body 1 in a direction away from the body 1. In particular, the signal amplifier 3 is protruded on the extension portion 1E of the body 1 and is located opposite to the signal sensing segment 2b of the signal detection element 2, so that when the body 1 surrounds the target object T to be detected, the multiple protruding structures 31 of the signal amplifier 3 are partially or completely in contact with the target object T to be detected, so that the signal amplifier 3 can be in closer contact with the target object T to be detected, so as to strengthen the intensity of the sensing signal corresponding to the information to be monitored received by the signal sensing segment 2b. Optionally, the protruding structure 3 has a cylindrical, semicircular, semi-elliptical, trapezoidal, etc. shape, but is not limited to the above shapes.

Preferably, when each of the protruding structures 31 contacts the target object T, it is partially or completely pressed into the target object T. In particular, the pressing condition refers to that the target object T is softer than the multiple protruding structures 31, and as the body 1 surrounding the target object T changes from loose to tight, each of the protruding structures 31 contacting the target object T will cause the depth of the depression of the contacted area of the target object T to change from shallow to deep. It should be noted that the pressing condition is preferably based on the principle of not affecting the normal function of the target object T and not damaging the target object T. In this way, by partially or completely pressing each protruding structure 31 into the target object T to be detected, the contact area between the signal amplifier 3 and the target object T to be detected can be increased, thereby strengthening the intensity of the sensing signal corresponding to the information to be monitored received by the signal sensing segment 2b.

According to the structural configuration of the signal detection device of the present invention, the entire signal detection device (especially all) can be made of biodegradable materials, especially biodegradable materials approved by the U.S. Food and Drug Administration (FDA). In this way, the signal detection device can be placed in the body of the target organism and can be degraded within a predetermined time without further surgery to remove it, thereby avoiding the risk of another surgery. The predetermined period is, for example, 3 to 26 weeks, preferably 13 to 26 weeks; however, the predetermined period can be changed in accordance with the actual period of signal monitoring, such as material and thickness, and is not limited to the time period cited above.

In a specific application example, the signal detection device can be used to be buried in the human body to measure the blood flow rate (corresponding to the aforementioned information to be monitored) of a blood vessel (corresponding to the target object T to be detected). As for the degradable material, the main body 1 can be composed of at least one of polyhydroxybutyrate (PHB), polyhydroxyvalerate (PHV) and poly-L-lactic acid (PLLA). The signal detection element 2 can be composed of a biodegradable metal, preferably magnesium metal. The signal amplification part 3 can be selected from polycaprolactone (PCL). The fixing part 4 can be selected from polydioxanone and L-lactide glycolide polymer. As for the size configuration of the overall device, as shown in FIG. 1 , the head portion 1H of the body 1 has a length L _H and a width W _H both between 5 mm and 35 mm, preferably between 10 mm and 30 mm, and more preferably between 15 mm and 20 mm; and a thickness _TH between 50 μm and 350 μm. The extension portion 1E has a width _WE between 2 mm and 15 mm, preferably between 5 mm and 10 mm; and a thickness _TE between 50 μm and 350 μm; and the length _LE of the extension portion 1E is configured according to actual needs. Corresponding to the configuration direction of the length, width, thickness/height of the main body 1, the thickness of the signal transmission segment 2a and the signal sensing segment 2b of the signal detection element 2 are both between 5 and 100 μm, preferably between 10 and 50 μm, and more preferably between 10 and 15 μm; the signal transmission segment 2a and the signal sensing segment 2b are respectively configured to correspond to the head 1H and the extension 1E of the main body 1 in terms of length and width, and in particular, the dimensions in length and width are respectively smaller than the head 1H and the extension 1E, so that the signal detection element 2 can be set inside the main body 1. The diameter of the through holes of the first assembly part 11A and the second assembly part 11B is 10-30% of the width _WE of the extension part 1E, preferably 15-25%, and more preferably 20%; the center distance between the two through holes of the first assembly part 11A and the second assembly part 11B is 1.5-6 times, preferably 1.5-3 times, and more preferably 1.5-2 times the diameter of the through holes. The sum of the diameters of the through holes and the distances between the through holes must be less than the width _WE of the extension part 1E in which they are provided.

In a specific example, the length, width, and height of each protrusion structure 31 in the signal amplifier 3 are all between 0.1 and 500 μm. In particular, according to the present invention, when the protrusion structure 31 is cylindrical, the sensed signal is significantly improved. Specifically, when the protrusion structure 31 is cylindrical, its diameter is between 10 and 500 μm, preferably between 250 and 400 μm, and more preferably between 300 and 350 μm; its height is between 1.5 and 100 μm, preferably between 40 and 75 μm, and more preferably 50 μm. There is a distance between each of the protruding structures 31, and in particular, the distance is defined by the center points of any two protruding structures 31, and the distance is 1.5 to 5 times the diameter, preferably 2 to 3.5 times.

It should be noted that, based on the shape and size of the protruding structure 31 proposed in the present invention, the signal detection device of the present invention can measure the vascular signal of the artery or vein, especially the venous vascular signal, and can stably obtain the change trend of the blood flow rate regardless of the vascular contraction or relaxation period. In detail, see FIG. 7, which shows that the signal detection device of the present invention with the protruding structure 31 surrounds and measures the signal characteristics of a biological venous blood vessel (target object T to be measured), and can measure a proximal vascular signal, a distal vascular signal and a normal vascular signal. The definition of "proximal" refers to the signal measured when a blood clamp (not shown) is placed on the measured venous vessel to reduce the blood flow rate downstream of the clamp (reduce the signal strength), and the signal detection device is placed downstream of the clamp and about 5 mm away from the blood clamp; the definition of "distal" refers to the signal measured when the signal detection device is placed downstream of the clamp and about 10 mm away from the blood clamp; and the "normal" refers to the signal measured by the signal detection device when the measured venous vessel is in a natural state without the placement of the blood clamp. On the contrary, compared with a comparative experiment (experiment disclosed by Stanford University), the comparative experiment used a pyramid-shaped protrusion structure, and the optimal size configuration was that the base (maximum side length) of the pyramid-shaped protrusion structure was 50μm, and the minimum edge spacing between each protrusion structure was 40μm; however, the comparative experiment could only measure the blood flow velocity changes in the arteries. Among them, the location where thrombosis is prone to occur after surgery is in the veins, so the venous blood vessel signals need to be highly monitored; however, the blood flow fluctuation/signal of the veins is smaller than that of the arteries, and has information that is difficult to measure the signal. Therefore, the present invention breaks through the limitation of the above comparative experiment that can only measure the arterial blood vessel signals, making the measured signals more valuable for reference. In particular, the present invention simulates the blockage of venous vessels through a vascular clamp, and the signal sensing device of the present invention can still measure the corresponding blood flow signal to reflect the changes in blood flow in the monitored blood vessels, which can greatly increase the application range of vascular signal monitoring. In addition, it should be noted that the above experiments of the present invention are conducted on the veins of living animals (such as rabbits); in particular, the diameter of the veins of the living body in the experiment is smaller than that of the human body. Through the signal detection device of the present invention, a stable quality interpretable signal can still be measured, which further proves its excellent performance in signal transmission and sensing effect.

In summary, the signal detection device of the present invention can be combined with a fixing member through the configuration of the assembly structure, so that the signal detection device can be fixed on the target object to be detected. In addition, through the configuration of the marking feature, the assembly structure can be more easily aligned. The protruding structure of the signal amplifier is protruding from the extension of the body and aligned with the signal sensing segment of the signal detection element also located in the extension of the body, so that the intensity of the sensing signal corresponding to the information to be monitored received by the signal sensing segment can be enhanced. In addition, the shape of the protruding structure is cylindrical, with a diameter between 250 and 400 mm, preferably between 300 and 350 μm, and a height between 40 and 75 μm, which can further enhance the intensity of the sensing signal. In addition, through the size configuration of the main body, signal detection element and signal amplifier, it can be applied to detect signals in specific organs or tissues inside a biological body (especially a human body), especially to detect signals in blood vessels. In addition, through the signal detection device of the present invention, the entire device can be made of biodegradable materials, and the overall size configuration can be applied to be installed in the human body to detect signals of interest, and can be completely degraded within a predetermined period of time without further surgery to remove it, thereby avoiding the risk of another surgery.

Although the present invention has been disclosed using the above preferred embodiments, they are not intended to limit the present invention. Any person skilled in the art may make various changes and modifications to the above embodiments within the spirit and scope of the present invention, and the changes and modifications are still within the technical scope protected by the present invention. Therefore, the protection scope of the present invention shall include all changes within the meaning and equivalent scope recorded in the attached patent application scope.

1: Body

1H: Head

1E: Extension

11: Assembly structure

11A: First assembly department

11B: Second assembly section

2:Signal detection element

2a: Signal transmission segment

2b: Signal sensing section

3: Signal amplifier

31: Protruding structure

L _H , _LE : Length

M: Signature feature

_TH , _TE :Thickness

W _H , _WE :Width

X,Y,Z: reference axis

Claims (10)

A signal detection device comprises: a body having an assembly structure, wherein the assembly structure has a first assembly part and a second assembly part which are arranged on the body at intervals; a signal detection element having a signal transmission section and a signal sensing section which are electrically connected to each other and are arranged inside the body; and a fixing member, wherein in a case where a part of the body forms a surrounding part and surrounds a target object to be detected, the first assembly part and the second assembly part are aligned with each other, and the fixing member is inserted into the first assembly part and the second assembly part which are aligned with each other, so that the fixing member is combined with the first assembly part and the second assembly part to maintain the shape of the surrounding part; a part or all of the signal sensing section is located in the surrounding part. The signal detection device of claim 1 further comprises a signal amplifier, the signal amplifier having a plurality of protruding structures, the plurality of protruding structures protruding outward from the main body; the protruding structure is cylindrical in shape, has a diameter between 250 and 400 μm, and has a height between 40 and 75 μm; in the case where a part of the main body forms the surrounding part, the signal amplifier is partially or completely in contact with the target object to be detected. As in claim 2, the signal detection device, wherein the diameter of the protruding structure is between 300 and 350 μm, and the height of the protruding structure is 50 μm. As in claim 1, the signal detection device, wherein the first assembly part and the second assembly part respectively have at least one through hole; the fixing member has a connecting portion, an inserting portion and a buckle portion; the inserting portion extends outward from the connecting portion; the buckle portion protrudes outward from a position of the inserting portion; in a case where the fixing member is combined with the first assembly part and the second assembly part, the inserting portion extends through the through holes of the first assembly part and the second assembly part that are aligned with each other, the connecting portion is located on one side of one of the first assembly part and the second assembly part, and the buckle portion is clamped against one side of the other of the first assembly part and the second assembly part. As in claim 4, the signal detection device, wherein each of the through holes has a through hole diameter in the radial direction; the buckle portion has an entry end and a buckle end, the entry end is located at an end facing away from the connecting portion, and the buckle end is located between the connecting portion and the entry end; the entry end is formed into a shape with a gradual expansion toward the buckle end, so that the length of the buckle portion in the radial direction gradually increases along an axial direction. As in the signal detection device of claim 4, the first assembly part and the second assembly part each have two through holes, and the insertion part of the fixing member forms two protruding structures corresponding to the number of the through holes, so that the fixing member has a U-shape or a V-shape as a whole. A signal detection device as claimed in any one of claims 1 to 6, wherein the main body further has a plurality of marking features, each of which is arranged on the main body to align with the position of the first assembly part and the second assembly part. As in claim 7, the signal detection device, wherein each of the marking features is a triangular notch, and a vertex of the triangular notch is aligned with the first assembly part and the second assembly part. A signal detection device as claimed in claim 7, wherein each of the marking features is a linear mark. A biodegradable signal detection device is a signal detection device as described in any one of claims 1 to 9, and the signal detection device is made of one or more biodegradable materials.

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