TWI843864B - Solid preparation for controlling rice pests containing flupyridine - Google Patents

Abstract

The present invention is a solid preparation for controlling rice pests, which contains at least one active ingredient selected from the group consisting of flupyrimin and its salts represented by the following formula (1), a solid carrier, a surfactant, and a binder. And it is a coated granule or an extruded granule.

Description

Solid preparation for controlling rice pests containing flupyridine

The present invention relates to a solid preparation for controlling rice pests containing fluopyrazine, and more specifically, to a solid preparation for controlling rice pests in the form of coated granules or extruded granules, a method for controlling rice pests using the same, and a method for producing the solid preparation for controlling rice pests.

More than 90% of rice, the staple food in Asia, is produced in Asia, especially in China, India, and Indonesia, which account for 60% of the world's production (Non-patent Document 1). In such regions, rice cultivation (rice cultivation) has become a problem due to the damage caused by butterfly moth pests that damage the aboveground parts and hemiptera pests that suck the sap stems and leaves, resulting in reduced yields. In particular, the butterfly moth pests, the Chilo suppressalis, and the hemiptera pests, the flies, bring great damage. The loss of rice production due to diseases and pests is as high as 45% (Non-patent Document 2). In order to increase rice production, the prevention and control of these rice pests has become necessary.

At present, for these rice pests that occur at different times, effective pesticides are used for each pest separately or in combination to control them (systemic control). When multiple treatments are performed, the personnel costs and labor related to the pesticide treatment are consumed. In addition, the occurrence of pests with reduced sensitivity to existing pesticides has become a problem (non-patent documents 3 and 4). Existing pesticides such as organophosphates, carbamates, and synthetic pyrethroids are restricted in use due to their adverse effects on non-target organisms. Therefore, it is desired to create a novel formulation that has a wide range of control activity and a long duration, does not show cross-resistance with existing pesticides, and has low impact on the environment.

Flupyralid has been reported as a pest control agent, which has insecticidal effects on Hemiptera pests such as flies or Butterfly pests such as striped stem borers that occur on rice (Rice, etc.), or does not show cross-resistance with existing drugs, and has low impact on the environment (Patent Document 1). It has also been reported that it can be mixed with other insecticides or fungicides for the control of flies and striped stem borers (Patent Document 2). However, there is still a lack of research on the specific formulation form or method of use in practical scenarios of rice production, especially the duration of the control activity. [Prior Art Document] [Patent Document]

[Patent Document 1] International Publication No. 2012/029672 [Patent Document 2] International Publication No. 2013/129688 [Non-Patent Document]

[Non-patent document 1] AMIS Market Database, retrieved on September 20, 2018, Internet, <URL: http://statistics.amis-outlook.org/data/index.html> [Non-patent document 2] India Crop Protection Chemicals (Pesticides) Market-Growth, Trends and Forecast (2017-2022), Mordor Intelligence Report (December 2017) [Non-patent document 3] Pest Management Science, Vol. 73(6), 1169-1178(2017) [Non-patent document 4] Scientific Reports, (2018) 8: 4586|DOI: 10.1038/s41598-018-22906-5

[Problems to be solved by the invention]

The present invention was completed in view of such a situation, and aims to provide a novel solid preparation for controlling harmful organisms, especially rice pests, with a very long duration of control activity, a rice pest control method using the same, and a method for producing the solid preparation for controlling rice pests. [Means for solving the problem]

The inventors of the present invention have made great efforts to solve the above-mentioned problems and have found that as a solid preparation, at least one active ingredient selected from the group consisting of fluopyridine and its salts is combined with a specific solid carrier, a surfactant and a binder to form a specific coated granule or extruded granule, which exhibits excellent control activity against rice pests, and the control activity lasts particularly long, and finally the present invention is completed. That is, the present invention provides the following.

[1] A solid preparation for controlling rice pests, comprising at least one active ingredient selected from the group consisting of fluazifop and its salts represented by the following formula (1), a solid carrier, a surfactant, and a binder.

The granules are coated granules or extruded granules.

[2] The solid preparation for controlling rice pests as described in [1] is a coated granule, wherein the solid carrier comprises core particles and an extender.

[3] The solid preparation for controlling rice pests as described in [2], wherein the particle size of the core particles is 63μm~6mm.

[4] A solid preparation for controlling rice pests as described in [2] or [3], wherein the core particles are at least one selected from the group consisting of silica sand, granular calcium carbonate, diatomaceous earth particles, granular clay and pumice.

[5] A solid preparation for controlling rice pests as described in any one of [2] to [4], wherein the extender is at least one selected from the group consisting of clay, calcium carbonate, kaolin and silicon dioxide.

[6] A solid preparation for controlling rice pests as described in any one of [2] to [5], wherein the binder is at least one selected from the group consisting of liquid paraffin, vegetable oil, polyethylene glycol and polypropylene glycol.

[7] The solid preparation for controlling rice pests as described in [1] is an extruded granule, the solid carrier comprises an extender, and the surfactant comprises a granulation improver and a disintegrating/dispersing agent.

[8] A solid preparation for controlling rice pests as described in [7], wherein the extender is at least one selected from the group consisting of clay, talc, calcium carbonate, kaolin, silicon dioxide and bentonite.

[9] A solid preparation for controlling rice pests as described in [7] or [8], wherein the granulation improving agent is at least one selected from the group consisting of sodium lauryl sulfate, sodium dialkyl sulfosuccinate and sodium alkylbenzene sulfonate.

[10] A solid preparation for controlling rice pests as described in any one of [7] to [9], wherein the disintegrating/dispersing agent is at least one selected from the group consisting of sodium lignin sulfonate, calcium lignin sulfonate, sodium naphthalene sulfonate formalin condensate, sodium polyacrylate, polyoxyethylene alkyl ether sodium sulfate, polyoxyalkylene styrene phenyl ether sodium sulfate, polyoxyalkylene styrene phenyl ether sodium phosphate, and polyoxyethylene/polyoxypropylene polymer sodium sulfate.

[11] A solid preparation for controlling rice pests as described in any one of [7] to [10], wherein the binder is at least one selected from the group consisting of polyvinyl alcohol, dextrin, sugar, sodium carboxymethylcellulose, hydroxypropylmethylcellulose and methylcellulose.

[12] A method for controlling rice pests comprises the step of applying an effective amount of a solid preparation for controlling rice pests as described in any one of [1] to [11] to at least one selected from the group consisting of rice pests, rice, soil and field water surface.

[13] A rice pest control method as described in [12], wherein the rice pest is at least one selected from the group consisting of flies and rice stem borers.

[14] A rice pest control method as described in [12] or [13], wherein the rice pest is a pesticide-resistant pest.

[15] A rice pest control method as described in any one of [12] to [14], wherein the effective amount of the solid preparation for rice pest control is 1g to 1kg of the active ingredient per 10 hectares of cultivated land.

[16] A method for producing a solid preparation for controlling rice pests, which is a method for producing a solid preparation for controlling rice pests as described in any one of [2] to [6], and is characterized by comprising: a wetting step of adding the aforementioned binder, or the aforementioned binder and the aforementioned surfactant, to the aforementioned core particles to make them wet, thereby obtaining wet core particles; a mixing and grinding step of mixing the aforementioned active ingredient, the aforementioned surfactant and the aforementioned extender, or the aforementioned active ingredient and the aforementioned extender and grinding them to obtain a first mixed and ground product; and a step of mixing the aforementioned wet core particles with the first mixed and ground product to obtain a coated granule in which the surface of the aforementioned wet core particles is coated with the first mixed and ground product.

[17] A method for producing a solid preparation for controlling rice pests, which is a method for producing a solid preparation for controlling rice pests as described in any one of [7] to [11], characterized in that it comprises: a mixing and pulverizing step of obtaining a second mixed pulverized product by mixing and pulverizing the aforementioned active ingredient, the aforementioned extender and the aforementioned binder, or mixing and pulverizing the aforementioned active ingredient, the aforementioned extender and the aforementioned binder with the aforementioned granulation improving agent and/or the aforementioned disintegrating/dispersing agent to obtain a mixed pulverized product, and a kneading step of obtaining a kneaded product by kneading the second mixed pulverized product with water, or kneading the second mixed pulverized product with water and the aforementioned granulation improving agent and/or the aforementioned disintegrating/dispersing agent, and a step of molding the mixed pulverized product with an extrusion granulator to obtain an extruded granule. [Invention Effect]

According to the present invention, it is possible to provide a novel solid formulation for controlling harmful organisms, especially rice pests, having a very long duration of control activity, a rice pest control method using the same, and a method for producing the solid formulation for controlling rice pests.

Furthermore, fluopyridine and/or its salts (preferably acid addition salts) do not show cross-resistance with other drugs, are highly safe against non-target organisms, and exert sufficiently excellent control activity at low concentrations, but according to the present invention, these can be particularly sustained for a long period of time. For example, by treating once with the solid preparation of the present invention containing fluopyridine and/or its acid addition salt as an active ingredient, two or more types of rice pests, including the rice stem borer and the flying lice, which occur at different times and cause great damage to rice, can also be suppressed at a low density for a long period of time. Therefore, according to the present invention, it is expected that the rice yield will be increased, and the problems faced by existing pesticides, such as reduction of pesticide sensitivity, impact on the environment, sustainability of effects, impact on non-target organisms, and reduction of labor for farmers, can be solved.

Hereinafter, the present invention will be described in detail according to its suitable implementation forms.

<Solid preparation> The present invention provides a solid preparation for controlling rice pests (hereinafter referred to as "solid preparation" as the case may be), which contains at least one active ingredient selected from the group consisting of fluopyridine and its salts represented by the following formula (1), a solid carrier, a surfactant, and a binder.

It is a coated granule or an extruded granule.

According to one aspect of the solid preparation of the present invention, a solid preparation (hereinafter referred to as "coated granules" as appropriate) is provided, which is a coated granule, and the solid carrier comprises core particles and an extender. In addition, according to another aspect of the solid preparation of the present invention, a solid preparation (hereinafter referred to as "extruded granules" as appropriate) is provided, which is an extruded granule, the solid carrier comprises an extender, and the surfactant comprises a granulation improver and a disintegrating/dispersing agent.

In the present invention, the "solid preparation for controlling rice pests" includes, in addition to agents for killing or weakening the following rice pests, agents for eliminating rice pests from the following rice, agents for preventing and controlling the parasitism of rice pests on rice, and agents for protecting rice from being attacked by rice pests.

(Fluoropyridine) The active ingredient of the present invention, Fluoropyridine, is a compound represented by the above formula (1), that is, N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide. Fluoropyridine can be synthesized according to the production method described in International Publication No. 2012/029672 (Patent Document 1), for example.

Furthermore, the salt of fluopyridine as the active ingredient of the present invention is preferably an acid addition salt, and the acid addition salt of fluopyridine is more preferably an acid addition salt acceptable for pesticides. Examples of the acid addition salt include hydrochlorides, nitrates, sulfates, phosphates, and acetates.

The active ingredient of the present invention may be either fluazifop or a salt of fluazifop or a combination of two or more thereof.

(Rice pests) The rice pests that the solid preparation of the present invention shows control activity against are pests that can feed on the leaves, stems, roots and ears of rice; and pests that can suck sap from the leaves, stems and ears of rice. Although such rice pests are not specifically limited, for example, as pests in agriculture, there are Lepidoptera (Order Butterflies) pests (Mythimna Separata, Cnaphalocrocis patnalis (Marasmia patnalis), Naranga aenescens, Parnara guttata, Plusia festucae, Mythimna loreyi, Protodeltote distinguenda, Spodoptera depravata, Pelopidas mathias, etc.); Chilo suppressalis (Chilo suppressalis, suppressalis), yellow stem borer (Scirpophaga incertulas), soil thief moth (Sesamia inferens), Scirphophaga innotata, Chilo polychrysus, Chilo auricilius, etc.), Hemiptera (aphids such as rice aphid, long-horned wheat aphid, rice root aphid, thick long-haired grass root aphid, etc.; leaf hoppers such as black-tailed leaf hopper, electric leaf hopper, etc.; flies such as gray fly, brown fly, white-backed fly, etc.; stink bugs such as red-striped blind tree, black rice stink bug, Chinese rice edge tree, white-spotted stink bug, long-shouldered spiny edge stink bug, white-spotted stink bug, rice green stink bug, rice leaf bug, etc.), Coleoptera (rice water weevil, rice weevil, bean sedge, rice mudworm, rice iron beetle (Dicladispa armigera), etc.), ticks (Steneotarsonemus spinki, etc.), Hymenoptera pests, Orthoptera pests (small-winged rice grasshoppers, black-necked hooked grasshoppers, crickets, etc.), Diptera pests (rice leaf miners, rice stem miners, rice gall midges (Orseolia oryzae), etc.), Lycoptera pests (rice weevils, rice pipe weevils, etc.), plant parasitic nematodes (Besse nematodes, rice root knot nematodes (Meloidogynae graminicola), etc., and may be one of them alone or a combination of two or more thereof. Among them, preferably, pests of the order Butterflies, Hemiptera, Leptera, Diptera, and Coleoptera can be listed, more preferably, flies, striped stem borers, and leaf crickets can be listed, more preferably, striped stem borers, yellow stem borers, gray flies, brown flies, white-backed flies, black-tailed leaf crickets, and electric leaf crickets can be listed, and more preferably, flies and striped stem borers among these can be listed.

In addition, the rice pests mentioned above may be pests resistant to existing drugs that reduce the sensitivity of the drugs to nicotine acetylcholine receptors such as imidocloprid, GABA receptor-acting compounds such as fipronil and isaprol, and diamide compounds such as cyproconazole.

(Other pest control agents) As the solid preparation of the present invention, since the active ingredients fluopyram and its salts show excellent control activity against the above-mentioned rice pests by themselves, although it is sufficient to contain the fluopyram and/or its salts, it can also show more excellent control activity against more pests by mixing with other pest control agents, so other pest control agents can be further contained. As other pest control agents that may be contained, insecticides (including miticides and nematicides), fungicides, herbicides and plant growth regulators can be listed. As specific agents, for example, those listed in the Pesticide Manual (17th edition, published by The British Crop Protection Council) and (SHIBUYA INDEX, 2014, published by SHIBUYA INDEX RESEARCH GROUP) can be listed. Among these, insecticides and fungicides are preferred as the other pest control agents mentioned above.

Preferred examples of the aforementioned other pest control agents include, for example, organophosphate compounds, phenylcarbamate compounds, worm toxin derivatives, organochlorine compounds, pyrethroid compounds, benzoylurea compounds, juvenile hormone-like compounds, scutellaria-like compounds, nicotine-like compounds, sodium channel blockers of nerve cells, insecticidal macrolides, γ-aminobutyric acid (GABA) antagonists, ryanodine receptor-active compounds, insecticidal ureas, BT agents, insect pathogenic virus agents, polyether antibiotics, thiamine antagonists, and sulfa (sulfa) agent and folic acid antagonist mixtures.

More specifically, as insecticides, there can be mentioned acephate, dichlorvos, EPN, fenitrothion, fenamifos, prothiofos, profenofos, pyraclofos, chlorpyrifos-methyl, diazinon, fosthiazate, imicyafos, phorate ) organic phosphate compounds; such as methomyl, thiodicarb, aldicarb, oxamyl, propoxur, carbaryl, fenobucarb, ethiofencarb, fenothiocarb, pirimicarb, carbofuran, carbosulfan, benfuracarb, b) phenylcarbamate compounds; sandworm toxin derivatives such as cartap and thiocyclam; organochlorine compounds such as dicofol and tetradifon; such as permethrin, tefluthrin, cypermethrin, deltamethrin, cyhalothrin, fenvalerate, fluvalinate , ethofenprox, silafluofen, cyhalothrin; benzoylurea compounds such as diflubenzuron, teflubenzuron, flufenoxuron, chlorfluazuron; juvenile hormone-like compounds such as methoprene; dermatophenone-like compounds such as chromafenozide; imidacl Nicotine acetylcholine receptor-acting drugs such as oprid, clothianidin, thiamethoxam, acetamiprid, nitenpyram, thiacloprid, dinotefuran, sulfoxaflor, flupyradifurone, dicloromezotiaz, and triflumezopyrim; such as flubendiamide, diamide compounds such as ubendiamide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, and tetraniliprole; GA such as ethiprole, fipronil, pyrafluprole, pyriprole, broflanilide, and fluxametamide BA receptor-active compounds; respiratory chain electron transport complex I inhibitory compounds such as pyridaben, fenpyroxymate, pyrimidifen, tebufenpyrad, tolfenpyrad; respiratory chain electron transport complex II inhibitory compounds such as cyflumetofen, cyenopyrafen, pyflbumide; respiratory chain electron transport complex II inhibitory compounds such as fluacrypyrim, ace Respiratory chain electron transport system complex III inhibitory compounds such as quinocyl and flometoquin; ACCase inhibitory compounds such as spirodiclofen, spiromesifen, and spirotetramat; Macrolide compounds such as spinosad, avermectin, milbemycin, spinetoram, lepimectin, and emamectin benzoate.

Further, as other compounds, there can be listed buprofezin, hexythiazox, amitraz, chlordimeform, ethoxazole, pymetrozine, bifenazate, flonicamid, chlorfenapyr, pyriproxyfen, indoxacarb, trifluoromethylpyrifos, and chlorfenapyr. pyridalyl), pyrifluquinazon, metaflumizone, hydramethylnon, triazamate, afidopyropen, renofluthrin, chloroprallethrin, cyhalodiamide, fluazaindolizine, ε-methobenzyl Epsilon-metofluthrin, epsilon-momfluorothrin, kappa-bifenthrin, kappa-tefluthrin, fluhexafon, tioxazafen, momfluorothrin, heptafluthrin, pyriminostrobin ), cycloxaprid, isocycloseram, oxazosulfyl, tyclopyrazoflor, spiropidion, acynonapyr, dimpropyridaz, organometallic compounds, dinitro compounds, organosulfur compounds, urea compounds, triazine compounds, hydrazine compounds, and microbial pesticides such as BT agents and insect pathogenic virus agents. In addition, as the aforementioned pesticides, the acid addition salts of these pesticides that are allowed.

The aforementioned insecticide may be one of the above-mentioned insecticides alone or a combination of two or more thereof. Among them, preferred insecticides include cartap, thiocyclam, phorate, flubendiamide, chlorantraniliprole, cyantraniliprole, carbofuran, and fipronil.

More specifically, as fungicides, for example, strobilurin compounds such as azoxystrobin, kresoxym-methyl, trifloxystrobin, metominostrobin, orysastrobin, etc.; anilinopyrimidine compounds such as mepanipyrim, pyrimethanil, cyprodinil, etc.; ne compounds; such as triadimefon, bitertanol, triflumizole, metoconazole, propiconazole, penconazole, flusilazole, myclobutanil, cyproconazole, tebuconazole, hexaconazole, prochloraz ), simeconazole; quinoxaline compounds such as quinomethionate; dithiophenylcarbamate compounds such as maneb, zineb, mancozeb, polycarbamate, and propineb; phenylphenylcarbamate compounds such as diethofencarb; chlorothalonil, quintozene, and pentachloronitrobenzene; e) organochlorine compounds; benzimidazole compounds such as benomyl, thiophanate-methyl, and carbendazole; phenylamide compounds such as metalaxyl, oxadixyl, ofurase, benalaxyl, furaxyl, and cyprofuram; sulfenic acid compounds such as dichlofluanid; copper hydroxide compounds such as Copper compounds such as hydroxide and oxine-copper; isoxazole compounds such as hydroxyisoxazole; organophosphorus compounds such as fosetyl-aluminium and tolclofos-methyl; N-halogen sulfide alkyl compounds such as captan, captafol, and folpet; procymidone, iprodione, and ethylenediamine; Dicarboximide compounds such as vinchlozolin; carboxyaniline compounds such as flutolanil, mepronil, furametpyr, thifluzamide, boscalid and penthiopyrad; morpholine compounds such as fenpropimorph and dimethomorph; organotin compounds such as fenthin hydroxide and fenthin acetate; cyanopyrrole compounds such as fludioxonil and fenpiclonil.

Further, as other compounds, tricyclazole, pyroquilon, carpropamid, diclocymet, fenoxanil, fthalide, fluazinam, cymoxanil, triforine, pyrifenox, fenarimol, fenpropidin, pencycuron, fumifenox, fenoxanil ... ferimzone, cyazofamid, iprovalicarb, benthiavalicarb-isopropyl, iminoctadin-albesilate, cyflufenamid, kasugamycin, validamycin, streptomycin, oxolinic-acid, tebufloquin, prothiazole benazole), tiadinil, isotianil, isoprothiolane, tolprocarb, pydiflumetofen, picarbutrazox, mandestrobin, dipymetitrone, pyraziflumid, oxathiapiprolin, penflufen, fluoxapiprol in, florylpicoxamid, fluopimomide, ipfenoquin, fluindapyr, isoflurane, quinofumelin, methyltetraprole, pyridachlometyl, pyrapropoyne, aminopyrifen, inpyrifluxam, dichlobentiazox, etc. In addition, as the aforementioned fungicides, the acid addition salts of these pesticides that are permitted can also be listed.

The aforementioned fungicide may be any one of the above or a combination of two or more thereof. Among them, preferred fungicides include azoxystrobin, orysastrobin, thifluzamide, furametpyr, fthalide, probenazole, acibenzolar-S-methyl, tiadinil, isotianil, isoprothiolane, toprolactone, and thiamethoxam. tolprocarb, carpropamid, diclocymet, fenoxanil, tricyclazole, pyroquilon, ferimzone, tebufloquin, simeconazole, validamycin, kasugamycin, pencycuron, penflufen, dichlobentiazox.

(Additives) The solid preparation of the present invention can be produced by using an additive (preferably an additive permitted for pesticides) with the active ingredient fluopyridine. As its form, granules can be listed, more specifically, coated granules or extruded granules containing a solid carrier, a surfactant and a binder.

[Solid carrier] As the aforementioned solid carrier, there can be listed talc, bentonite, clay, kaolin, diatomaceous earth, vermiculite, zeolite, silicon dioxide, calcium carbonate, ammonium sulfate, silica sand, silica, pumice, etc.

The coated granules of the present invention are the solid carriers containing core particles and extenders. Furthermore, the extruded granules of the present invention are the solid carriers containing extenders, and preferably do not contain the core particles, that is, the solid carriers only contain the extenders.

In the present invention, the so-called "core particle" refers to a solid carrier with a particle size of 63 μm or more. The particle size is preferably in the range of 63 μm to 6 mm, more preferably in the range of 75 μm to 2 mm, and even more preferably in the range of 106 μm to 2 mm. The "particle size" of the core particle or solid carrier of the present invention refers to the diameter of the circle when the particle is projected onto a plane. When the projection plane is not circular (when the particle is in the shape of a flat plate, plate, rod, polygon, etc.), it refers to the diameter of its circumscribed circle. As such core particles, there are no particular limitations as long as they satisfy the aforementioned particle size, but examples thereof include granular silica sand, diatomaceous earth, pumice, clay, calcium carbonate, etc., and they may be one of them alone or a combination of two or more thereof. In the present invention, in addition to the particles of the crushed product of each mineral, the granular calcium carbonate (granular calcium carbonate) and the granular clay (granular clay) also include particles of granulated products obtained by mixing and kneading a mineral fine powder having a small particle size with bentonite or the following binder, etc., and then extruding or crushing the granulated products.

In the present invention, the so-called "bulking agent" is mainly used for diluting the active ingredient, and specifically refers to a solid carrier with a particle size of less than 63 μm. As such a bulking agent, if it satisfies the aforementioned particle size, although there is no particular limitation, it is preferably the aforementioned coated granules, and from the viewpoint of facilitating the pulverization step in the following method for producing the coated granules, at least one of the group consisting of clay, calcium carbonate, kaolin and silicon dioxide. In addition, it is preferably the aforementioned extruded granules, and from the same viewpoint, at least one of the group consisting of clay, talc, calcium carbonate, kaolin, silicon dioxide and bentonite.

[Surfactant] As the aforementioned surfactant, there can be listed anionic surfactants, cationic surfactants, and nonionic surfactants.

As the surfactant contained in the coated granules of the present invention, among the above, it is preferred that the surfactant has the wetting effect of the core particles mentioned above, and specifically, for example, anionic surfactants such as sodium lignin sulfonate, sodium lauryl sulfate, sodium naphthalene sulfonate formalin condensate, polyoxyalkylene alkyl ether sodium sulfate, sodium alkylbenzene sulfonate, sodium dialkyl sulfosuccinate, polyoxyalkylene styrene phenyl ether sodium sulfate, polyoxyalkylene styrene phenyl ether sodium phosphate, etc. can be listed; The nonionic surfactants such as oxyalkylene sorbitan fatty acid esters (polyoxyalkylene sorbitan monolaurate, etc.), sorbitan fatty acid esters, sucrose fatty acid esters, polyoxyalkylene castor oil, polyoxyalkylene hydrogenated castor oil, polyoxyalkylene alkyl ethers, polyoxyalkylene alkylphenyl ethers, polyoxyalkylene styrylphenyl ethers, polyoxyethylene-polyoxypropylene block polymers, polyoxyalkylene alkylamines, etc. may be used alone or in combination of two or more. Among the above-mentioned surfactants, the above-mentioned nonionic surfactants or their combination may be used in the coated particles of the present invention with the following binder for the same purpose.

In the present specification, "polyoxyalkylene" means one of polyoxyethylene and polyoxypropylene or a mixture thereof.

The extruded granules of the present invention contain a granulation improving agent and a disintegrating and dispersing agent in the aforementioned surfactant.

In the present invention, the so-called "granulation improver" refers to the surfactants mentioned above, which have the function of improving the compatibility of water and other ingredients in the kneading step of the following production method. Specifically, it refers to the surfactants that show a surface tension value of 10 to 35 mN/m at 25° C. when it is set as a 0.1% aqueous solution. As such a granulation improver, as long as it satisfies the above surface tension, although it is not particularly limited, in the above extruded granules, it is preferably at least one selected from the group consisting of sodium lauryl sulfate, sodium dialkyl sulfosuccinate and sodium alkylbenzene sulfonate.

In the present invention, the so-called "disintegrating and dispersing agent" means that among the above-mentioned surfactants, in addition to the above-mentioned granulation improving agent, it has the effect of improving at least one of the dispersibility and disintegration of other components of the above-mentioned active ingredients. As such a disintegrating and dispersing agent, preferably anionic surfactants can be listed, and more preferably sodium lignin sulfonate, calcium lignin sulfonate, sodium naphthalene sulfonate formalin condensate, sodium polyacrylate, polyoxyethylene alkyl ether sodium sulfate, polyoxyalkylene styrene phenyl ether sodium sulfate, polyoxyalkylene styrene phenyl ether sodium phosphate, polyoxyethylene and polyoxypropylene polymer sodium sulfate, and it can be one of them alone or a combination of two or more.

[Binder] In the present invention, "binder" is mainly used to increase the strength of solid preparations and/or to strengthen the connection between solid raw materials. Examples of such binders include cellulose derivatives such as sodium carboxymethylcellulose, hydroxypropylmethylcellulose or methylcellulose; polyacrylates such as sodium polyacrylate; polymethacrylates such as polymethyl methacrylate; polyvinyl derivatives such as polyvinyl alcohol or polyvinyl pyrrolidone; rubbers (vegetable rubbers, etc.) such as xanthan gum, guar gum, and gum arabic; starch; dextrin; sugars such as monosaccharides (fructose, glucose, galactose, etc.) or disaccharides (sucrose, maltose, lactose, etc.); glue; casein; gelatin; liquid paraffin; vegetable oils such as soybean oil or rapeseed oil; glycols such as polyethylene glycol or polypropylene glycol. The binder may be any one of these alone or a combination of two or more thereof.

As the binder contained in the coated granules of the present invention, it is preferred that at least one of the above-mentioned binders is selected from the group consisting of fluidized paraffin, vegetable oils and fats, polyethylene glycol and polypropylene glycol. In addition, as the binder contained in the extruded granules of the present invention, it is preferred that at least one of the above-mentioned binders is selected from the group consisting of polyvinyl alcohol, dextrin, sugars, sodium carboxymethylcellulose, hydroxypropylmethylcellulose and methylcellulose.

[Others] Furthermore, the solid preparation of the present invention (preferably coated granules) may further contain a coloring agent such as a red pigment or a blue pigment.

Furthermore, the solid preparation of the present invention may further contain at least one of other additives such as surfactants, emulsifiers, dispersants, disintegrants, wetting agents, spreaders, thickeners, binders, antifreeze agents, defoamers, colorants, anti-mold agents, etc. other than the above-mentioned additives, if necessary, within the range that does not hinder the effect of the present invention.

[Composition] The amount of the effective ingredient contained in the solid preparation of the present invention (when two or more fluopyridine or its salts are contained, the total amount thereof, the same below) depends on the purpose of use or the method of treatment, and is not particularly limited, but is generally 0.1 to 80% by weight, preferably 0.1 to 10% by weight, based on the free form of fluopyridine.

As preferred embodiments of the solid preparation of the present invention, the following can be cited. (1) Coated granules containing 0.1-10% by weight of fluopyridine, 20-98% by weight of core particles (granular solid carrier such as silica sand), 0.2-30% by weight (preferably 0.5-30% by weight) of extender, surfactant and binder, and the total amount is 100% by weight. (2) Extruded granules containing 0.1-10% by weight of fluopyridine, 0.5-30% by weight of surfactant and binder, and 20-98% by weight of extender (solid carrier), and the total amount is 100% by weight. granule), (3) an extruded granule containing 0.1 to 10% by weight of fluopyridine, 20 to 98% by weight of a bulking agent (solid carrier), 0.1 to 2.0% by weight of a granulation improving agent, 0.5 to 5.0% by weight of a disintegrating and dispersing agent, and 0.5 to 30% by weight of a binder, the total amount of which is 100% by weight.

<Method for producing solid preparation> The present invention, as one aspect of the method for producing the solid preparation of the present invention, provides a method for producing (hereinafter referred to as "method for producing coated granules" as the case may be), which comprises: adding the aforementioned binder or the aforementioned binder and the aforementioned surfactant to the aforementioned core particles to wet them, thereby obtaining a wetting step of obtaining a wet core particle, and mixing the aforementioned active ingredient, the aforementioned surfactant and the aforementioned extender, or the aforementioned active ingredient and the aforementioned extender and pulverizing them to obtain a first mixed pulverized product, and mixing the aforementioned wet core particles with the first mixed pulverized product to obtain a surface of the aforementioned wet core particles coated with the first mixed pulverized product. The invention relates to a step of preparing coated granules and a method for preparing the coated granules (hereinafter referred to as "method for preparing extruded granules"), which comprises: a mixing and pulverizing step of mixing the aforementioned active ingredient, the aforementioned extender and the aforementioned binder and pulverizing them, or mixing the aforementioned active ingredient, the aforementioned extender and the aforementioned binder with the aforementioned granulation improving agent and/or the aforementioned disintegrating/dispersing agent and pulverizing them to obtain a second mixed pulverized product, and a kneading step of kneading the second mixed pulverized product and water, or kneading the second mixed pulverized product and water with the aforementioned granulation improving agent and/or the aforementioned disintegrating/dispersing agent to obtain a kneaded product, and a step of molding the kneaded product with an extrusion granulator to obtain extruded granules.

[Manufacturing method of coated granules] The coated granules of the present invention are granules formed by coating the active ingredient and the extender with a binder on the surface of the core particles. The core particles are wetted with the binder in advance in order to be easily coated (wetting step). In the wetting step, the surfactant (preferably a non-ionic surfactant) may be further added. There is no particular limitation to such a wetting step, and although a conventionally known method or a method in accordance therewith may be appropriately adopted, for example, a method of spraying the binder and, if necessary, the surfactant on the core particles while mixing them may be cited. As a binder at this time, it can be used by diluting with a solvent such as water or ethanol.

In addition, the coated component is added with an extender in advance, uniformly mixed and crushed. That is, the aforementioned active ingredient, the aforementioned surfactant and the aforementioned extender are mixed and crushed (at least the aforementioned active ingredient and the aforementioned extender are crushed) to obtain the first mixed crushed product (mixing and crushing step). At this time, in the aforementioned wetting step, the aforementioned active ingredient and the aforementioned extender are mixed and crushed under the condition of adding the aforementioned surfactant to obtain the first mixed crushed product. As the aforementioned surfactant, it can be used in two steps, namely the wetting step and the mixing and crushing step. As such a crushing method, there is no particular limitation, and a previously known method or a method according to the method can be appropriately adopted, for example, a method using an impact mill such as a pin mill, a hammer mill or an air flow mill such as a jet mill can be cited.

The aforementioned wetting step and the mixing and pulverizing step may be performed either first or simultaneously. Then, the aforementioned wet core particles are mixed with the first mixed and pulverized product to obtain coated granules in which the surface of the aforementioned wet core particles is coated with the first mixed and pulverized product. Such a mixing method is not particularly limited, and a conventionally known method or a method in accordance therewith may be appropriately adopted, for example, a method using a container rotary mixer such as a concrete mixer; a container fixed mixer such as a ribbon mixer or a conical screw mixer may be cited.

The method for producing the coated granules may further include a drying step of drying the coated granules, if necessary. Such a drying method is not particularly limited, and a conventionally known method or a method in accordance therewith may be appropriately adopted.

[Manufacturing method of extruded granules] The extruded granules of the present invention are obtained by uniformly mixing and pulverizing the aforementioned active ingredient and the aforementioned extender, adding water and kneading, and molding them into granules. That is, first, the aforementioned active ingredient, the aforementioned extender, the aforementioned granulation improver, the aforementioned disintegrating/dispersing agent, and the aforementioned binder are mixed and pulverized (at least the aforementioned active ingredient and the aforementioned extender are pulverized) to obtain a second mixed pulverized product (mixing and pulverizing step). In the mixing and pulverizing step, the aforementioned granulation improver and/or the aforementioned disintegrating/dispersing agent are not added, but may be added in the next kneading step. As such a pulverizing method, the same method as the pulverizing method listed in the manufacturing method of the coated granules can be appropriately adopted. In this case, the binding agent may be dissolved in a solvent such as water or ethanol to be used in the form of a solution.

Next, without adding the second mixed pulverized product and water, or without adding the aforementioned granulation improving agent and/or the aforementioned disintegrating and dispersing agent in the aforementioned pulverizing step, the second mixed pulverized product and water are kneaded with the aforementioned granulation improving agent and/or the aforementioned disintegrating and dispersing agent to obtain a kneaded product. In addition, the aforementioned granulation improving agent and the aforementioned disintegrating and dispersing agent can be used in two steps of a mixing and pulverizing step and a kneading step, respectively. Such a kneading method is not particularly limited, and a conventionally known method or a method in accordance therewith can be appropriately adopted, for example, a method using a mixing and kneading machine such as a ribbon mixer, a conical screw mixer, a Henschel mixer, a double wrist kneading machine, etc. can be cited.

Next, the kneaded product is molded by an extrusion granulator to obtain extruded granules. Such molding method is not particularly limited, and a conventionally known method or a method in accordance therewith can be appropriately adopted. For example, as the extrusion granulator, there can be listed a structure by extrusion, and for the horizontal extrusion type, the front extrusion type, the rigid type, and the drum extrusion type, there can be listed a method in which the kneaded product is extruded from a screen or a die by applying pressure with a screw or a drum.

After the extrusion type granules are formed, if necessary, a drying step may be further included. Such a drying method is not particularly limited, and a conventionally known method or a method according to the method may be appropriately adopted.

According to another preferred aspect of the present invention, a combination is provided of the solid preparation of the present invention, i.e., the first component, and a composition comprising other pest control agents as active ingredients, i.e., the second component. In this case, the second component may be added with appropriate additives to form any dosage form. The combination may be provided in the form of a drug set or the like.

According to another aspect of the present invention, a method for protecting rice from rice pests is provided, which comprises applying the solid formulation of the present invention and at least one other pest control agent simultaneously or separately (preferably applying each component simultaneously) to the application object (area to be treated). In this method, "simultaneous" application also includes mixing the solid formulation of the present invention and at least one other pest control agent before applying them to the object, and applying the mixture. "Separately" application includes not mixing them in advance, applying the solid formulation of the present invention before other components, and applying the solid formulation of the present invention after other components.

<Method for controlling rice pests> The present invention provides a method for controlling rice pests (hereinafter referred to as "control method" as the case may be), which comprises the step of applying the solid preparation of the present invention to at least one selected from the group consisting of the aforementioned rice pests, rice, soil and field water surface.

In addition, in the present invention, the "rice pest control method" includes, in addition to the method of killing or weakening the aforementioned rice pests, a method of eliminating rice pests from the following rice, a method of preventing rice pests from parasitizing rice, and a method of protecting rice from being attacked by rice pests.

[Rice] As a plant to which the solid preparation of the present invention can be applied, although not particularly limited, rice (Oryza sativa, Oryza glaberrima) is preferred. Rice is a plant of the genus Oryza in the family Gramineae, and is specifically divided into two ecotypes, japonica rice (O. sativa subsp. japonica) and ramie rice (O. sativa subsp. indica), and intermediate varieties obtained by hybridization of these. Java rice is included in japonica rice.

Rice is cultivated in a wide range of regions, centered in the monsoon zone of Asia, under various climatic conditions. It is cultivated in the north from the banks of the Heilong River at the border between Russia and China, and in the south across Argentina. It is cultivated by irrigation in the mountainous areas of Nepal and India, and in the desert areas of Pakistan, Iran, and Egypt, but not in parts of Asia, Africa, and Latin America. Also, it is cultivated as floating rice in the delta areas of Asia.

Rice is divided into land rice and paddy rice according to the cultivation method. Land rice is directly sown in the field and cultivated in the field. Although paddy rice can also be cultivated by direct seeding directly in paddy fields, in Japan, the general cultivation method is to transplant seedlings into rice fields (field planting).

The normal cultivation temperature is above 20℃. Rice is cultivated in waterlogged fields. The minimum growth temperature is 10~12℃, and the temperature for flowering and fruiting must be 23℃. On the contrary, when it is raised to above 35℃, high temperature barriers will occur.

Rice, originally an aquatic plant, is one of the crops that requires a lot of water. Without irrigation, when the soil moisture is less than 10% at the surface layer and less than 12% at the subsoil layer, drought damage will occur. However, it can also be cultivated in salt-accumulating soils, alkaline or acidic soils.

The solid preparation of the present invention can be applied to rice cultivation, particularly preferably paddy rice cultivation, at any time from sowing (preferably after transplanting) to harvesting. For example, 2 to 5 weeks after transplanting the seedlings, by applying the solid preparation of the present invention to the water surface (field water surface) of the transplanted rice field (paddy rice field), the aforementioned rice pests occurring at different times can be prevented at one time. In addition, the aforementioned field water surface also includes the water surface of hydroponic cultivation equipment such as a Vashvili pot. In addition to the aforementioned field water surface, the solid preparation of the present invention can be applied to the soil including the cultivation carrier before transplanting, or the soil for cultivating the aforementioned land rice, etc., and can also be directly applied to the aforementioned rice pests or rice (preferably the stem and leaf parts). Among these, the target to which the solid preparation of the present invention is applied is preferably at least one of the aforementioned soil (cultivation soil and cultivation carrier before transplantation, soil for cultivating rice, etc.) and the aforementioned field water surface.

In the control method of the present invention, the solid preparation of the present invention can be applied directly or in a diluted form in an effective amount.

According to another aspect of the present invention, a method for protecting rice from rice pests is provided, comprising the step of applying an effective amount of the solid preparation of the present invention to at least one selected from the group consisting of the rice pests, the rice (preferably the stems and leaves), the soil, and the field water surface.

Furthermore, according to another aspect of the present invention, a use of the solid preparation of the present invention for protecting rice from rice pests is provided.

As a method of applying the solid preparation of the present invention to an object, there can be listed spreading treatment, field water treatment, soil treatment (spreading, mixing, pouring, etc.), etc., preferably, field water treatment and soil treatment can be listed.

As a method of using the solid preparation of the present invention for field water treatment and soil treatment, the solid preparation can be directly spread on the field water surface or soil surface, but after mixing with fertilizer or sand, any amount can be spread on cultivated land (rice field). As the treatment amount (i.e., effective amount) when applied by field water treatment and soil treatment, it is expected that the amount of the effective ingredient in the solid preparation of the present invention (the amount converted as the free body of fluopyridine or its salt, when containing two or more of these, the total amount of these, the same below) is 0.1g~10kg per 10 acres of cultivated land, preferably 1g~1kg.

Furthermore, as a soil treatment method using the solid preparation of the present invention, although not particularly limited, a method of directly applying the solid preparation of the present invention to the soil or on the soil surface can be preferably cited. More preferred soil treatment methods are scattering, belt, trench and planting hole application methods.

As other application methods, the solid preparation of the present invention can be applied to the nutrient solution of a hydroponic cultivation system such as thin-film hydroponics (NFT) or distilled-water hydroponics (DFT), or solid culture medium cultivation such as rock wool cultivation, or directly applied to artificial soil containing vermiculite and solid culture medium containing artificial mats for seedling cultivation. In addition, although it is not good from the perspective of long-term sustained control activity, the solid preparation of the present invention can be applied by dispersing in water or pouring the emulsified or dissolved solution into the soil. [Example]

Although the present invention is specifically described below by way of examples, the present invention is not limited to these examples. In addition, all raw materials in each formulation example are commercially available. In each formulation example, only solid carriers (core particles) with a particle size of 63 μm or more are recorded as particle sizes.

(Preparation Example) Preparation Example 1 [Extrusion Granules] Fluoropyrazine                      2 wt% Sodium lignin sulfonate                    3 wt% Sodium lauryl sulfate                    0.5 wt% Silicon dioxide                    2 wt% Polyvinyl alcohol                       1.5 wt% Clay                      91 wt% The above ingredients are uniformly mixed and pulverized, water is added and kneaded thoroughly, and the kneaded mixture is passed through an extrusion granulator, granulated and dried to obtain granules.

Preparation Example 2 [Extrusion Granules] Fluoropyrazine                  2 wt% Calcium lignin sulfonate                  3 wt% Sodium alkylbenzene sulfonate                  0.5 wt% Silicon dioxide                       2 wt% Polyvinyl alcohol                  1 wt% Clay                      91.5 wt% The above ingredients are uniformly mixed and pulverized, water is added and kneaded thoroughly, and the kneaded mixture is passed through an extrusion granulator, granulated and dried to obtain granules.

Preparation Example 3 [Extrusion Granules] Fluoropyrazine                    2 wt% Sodium polyacrylate                2 wt% Sodium dialkyl sulfosuccinate            0.3 wt% Sodium carboxymethylcellulose              1.5 wt% Calcium carbonate                  94.2 wt% Excluding sodium polyacrylate, the above ingredients are uniformly mixed and pulverized, sodium polyacrylate and water are added thereto and kneaded thoroughly, and the kneaded product is passed through an extrusion granulator, granulated and dried to obtain granules.

Preparation Example 4 [Extrusion Granules] Fluoropyrazine                     2 wt% Sodium lignin sulfonate               3 wt% Sodium alkylbenzene sulfonate              0.3 wt% Dextrin                    5 wt% Kaolin                        10 wt% Clay                      79.7 wt% The above ingredients are uniformly mixed and pulverized, water is added and kneaded thoroughly, and the kneaded mixture is passed through an extrusion granulator, granulated and dried to obtain granules.

Preparation Example 5 [Extrusion Granules] Fluoropyrazine                    2 wt% Sodium naphthalenesulfonate formalin condensate       3 wt% Sodium lauryl sulfate              0.3 wt% Sodium carboxymethylcellulose           1.5 wt% Talc                                 30 wt% Calcium carbonate                  63.2 wt% The above ingredients are uniformly mixed and pulverized, water is added and kneaded thoroughly, and the kneaded mixture is passed through an extrusion granulator, granulated and dried to obtain granules.

Preparation Example 6 [Coated Granules] Fluoropyrazine                            2 wt% Silica sand (granular: particle size 0.3~1.4 mm)  95.55 wt% Sodium lauryl sulfate                  0.1 wt% Silicon dioxide                     0.5 wt% Liquid wax                     1.15 wt% Red pigment                 0.2 wt% Kaolin                       0.5 wt% The above-mentioned silica sand and ingredients other than the liquid wax are uniformly mixed and pulverized to obtain a pulverized product. After the liquid wax is added to the silica sand and uniformly wetted, the pulverized product is added and uniformly mixed, and the pulverized product is coated on the core particles to obtain granules.

Preparation Example 7 [Coated Granules] Fluoropyrazine                  2 wt% Silica sand (granular: particle size 0.3~1.4 mm)  95.85 wt% Sodium lauryl sulfate                  0.1 wt% Silicon dioxide                   0.75 wt% Polypropylene glycol                   1.1 wt% Red pigment                        0.2 wt% The above-mentioned silica sand and components other than polypropylene glycol are uniformly mixed and pulverized to obtain a pulverized product. After adding polypropylene glycol to the silica sand and making it uniformly wet, the above-mentioned pulverized product is added and uniformly mixed, and the above-mentioned pulverized product is coated on the above-mentioned core particles to obtain granules.

Preparation Example 8 [Coated Granules] Fluoropyrazine                            2 wt% Sodium alkylbenzenesulfonate                     0.1 wt% Kaolin                           1 wt% Red pigment                       0.2 wt% Polyethylene glycol                         1.15 wt% Granular calcium carbonate (particle size 0.42~0.85 mm)         95.55 wt% The granular calcium carbonate and the components other than polyethylene glycol are uniformly mixed and pulverized to obtain a pulverized product. After polyethylene glycol is added to the granular calcium carbonate to uniformly wet it, the pulverized product is added and uniformly mixed, and the pulverized product is coated on the core particles to obtain granules.

Preparation Example 9 [Coated Granules] Fluoropyrazine                     2 wt% Sodium alkylbenzenesulfonate               0.1 wt% Silicon dioxide                   0.5 wt% Kaolin                   0.5 wt% Blue pigment                  0.2 wt% Polypropylene glycol                    1.15 wt% Silica sand (granular: particle size 0.25~1.0 mm)  95.55 wt% The above-mentioned silica sand and components other than polypropylene glycol are uniformly mixed and pulverized to obtain a pulverized product. After adding polypropylene glycol to the silica sand and uniformly moistening it, the pulverized product is added and uniformly mixed, and the pulverized product is coated on the above-mentioned core particles to obtain granules.

Preparation Example 10 [Coated Granules] Fluopyrazine                          2 wt% Kaolin                    1.5 wt% Blue Pigment                  0.2 wt% Sodium Dialkyl Sulfosuccinate          0.1 wt% Polyoxyalkylene Sorbitol Fatty Acid Ester     0.2 wt% Soybean Oil                     1 wt% Silica Sand (granular: particle size 0.25~1.0 mm)    95 wt% Fluopyrazine, kaolin, and blue pigment are uniformly mixed and pulverized to obtain a pulverized product. After adding a pre-mixed mixture of sodium dialkyl sulfosuccinate, polyoxyalkylene sorbitol fatty acid ester, and soybean oil to silica sand and uniformly moistening it, the pulverized product is added and uniformly mixed, and the pulverized product is coated on the core particles to obtain granules.

Comparative Preparation Example 1 [Flowing Agent] Fluoropyrazine                      10 wt% Sodium lignin sulfonate                   2.5 wt% Sodium dialkyl sulfosuccinate               0.2 wt% Propylene glycol                        10 wt% Xanthan gum                        0.3 wt% Polysilicone defoaming agent                   0.5 wt% Anti-mold agent (Organic nitrogen-sulfur complex, organic bromine compound)  0.03 wt% Water                    76.47% by weight After adding fluopyridine, sodium lignin sulfonate, sodium dialkyl sulfosuccinate, propylene glycol and polysilicone defoamer to water and mixing, wet grinding is performed by a bead mill to obtain a slurry (liquid A). Next, xanthan gum, anti-mold agent and water are mixed and dissolved to obtain an aqueous solution (liquid B). 780 parts by weight of the prepared liquid A and 230 parts by weight of liquid B are mixed to obtain a fluidizing agent.

Comparative Preparation Example 2 [Granular Hydration Agent] Fluoropyrazine                    20 wt% Sodium dialkyl sulfosuccinate               1 wt% Sodium lignin sulfonate                    7 wt% Silicon dioxide                                   1 wt% Clay       ...

(Test Example 1 Field test on rice stem borers and flies) Twenty-five days after field planting, the granules (extrudable granules) of Preparation Example 1 were applied to the rice field by surface water application (field surface water treatment) in a manner that the original amount (active ingredient amount, in fluopyridine, fluopyridine amount, the same below) became a specified amount. For the control preparation, 25 days after planting in the field, the preparation for controlling striped stem borers, Pedan 4% granules, were applied to the water surface in the amount of the original body (Pedan amount) to the specified amount. Three weeks after the treatment (21 days), the preparation for controlling flying flies, Bufenjing 25% liquid, was applied to the leaves in the amount of the original body (bufenjing amount) to the specified amount. For the untreated area, no preparation was applied.

14, 21, 28, and 35 days after the treatment (25 days after field planting), the number of tillers of 20 plants randomly selected in each area and the number of stems damaged by Chilo suppressalis (mainly Striped Stem Borer) were counted. The stem damage rate was calculated according to the following formula. Stem damage rate (%) = (number of damaged stems on each treatment day/total number of tillers of 20 plants) × 100 The results are shown in Table 1 below. In addition, after 14, 21, 28, 35, and 42 days, the solid counts (total number of adults and larvae) of flies (the total number of brown flies and white-backed flies) parasitizing each of 20 randomly selected plants in each area were counted as the number of fly parasites. The results are shown in Table 2 below.

The results of the test, as shown in Tables 1 and 2, show that the solid preparation of the present invention, i.e., fluopyramide granules, at a treatment amount of 100 g/ha, not only showed a higher damage inhibition effect on the striped stem borer than the control preparation, but also significantly inhibited the number of parasites of flying flies. On the other hand, in the treatment area (systemic control treatment area) of the control preparation of petan granules and fenfen clean flowable agent, the rate of stem damage caused by striped stem borer was lower than that of the untreated area, but the reduction rate of the number of parasites of flying flies was lower, resulting in a lower density inhibition effect on flying flies. Thus, it was confirmed that the fluopyramide granules of the present invention had long-term persistence after only one treatment, and showed higher control activity against striped stem borers and flies compared to systemic treatment of control formulations of the striped stem borers and flies.

In addition, the effect of each preparation on the rice yield was evaluated by comparing the weight of rice harvested from each treatment area. The results are shown in Table 3 below.

As shown in Table 3, in the treatment area of fluopyramide granules, it was confirmed that the systemic control treatment area of the control preparation was higher, and the yield of the untreated area was increased by 12%. Through the above results, according to the solid preparation (extruded granules) of the present invention, it was confirmed that through one treatment, not only the labor of rice pest control operation was reduced, but also a more excellent yield-increasing effect was shown compared with the control preparation.

(Test Example 2 Indoor test on brown fly) Rice 3 weeks after sowing was transplanted into a Warburg pot (1/5000a). 3 days after transplantation, the granules of Preparation Example 1 (extrusion type granules) or the granules of Preparation Example 6 (coated type granules) or Fluopyridine were applied to the water surface to treat the original body amount (field surface water treatment). For the untreated area, no preparations or drugs were applied. 3, 29, and 42 days after the day of preparation or drug treatment (3 days after transplantation), the second-instar larvae of brown fly were released into each pot, and the life and death of the larvae were observed 6 or 7 days after the release, and the corrected mortality rate was calculated according to the following formula. Corrected mortality rate (%) = [{(Number of surviving insects in the untreated area/Number of released insects)-(Number of surviving insects in the treated area/Number of released insects)}/(Number of surviving insects in the untreated area/Number of released insects)] × 100 The test was conducted in two consecutive runs. The results are shown in Table 4 below.

The test results are shown in Table 4. The solid preparation of the present invention, i.e., the coated granules and extruded granules of fluopyrazole, showed a higher corrected mortality rate than fluopyrazole even when rice pests were released 29 and 42 days after each treatment. Therefore, it was confirmed that by becoming such granules, the long-term sustainability was superior to that of fluopyrazole.

(Test Example 3 Field test on rice stem borer) The granules of Preparation Example 1 (extrusion type granules) were mixed with an appropriate amount of sand, and then treated by uniformly applying the original volume to the rice field 25 days after transplantation (field surface water treatment). On the same day, the flowable agent of Comparative Preparation Example 1 was diluted with water to a treatment water volume of 40L/10a, and then sprayed on the stems and leaves with a sprayer in such a way that the original volume became the specified amount. No preparation was applied to the untreated area. Although no stem damage caused by Chilo suppressalis (dominant species Yellow stem borer) was observed during the preparation treatment, the number of stems of each plant and the number of stem core blight caused by Chilo suppressalis (dominant species Yellow stem borer) were visually counted 28 days and 42 days after the treatment. A survey was conducted for every 30 plants in a ^25m2 area, and the stem damage rate was calculated using the following formula. Stem damage rate (%) = {(number of stem core blight per 30 plants)/(total number of stems per 30 plants)}×100 The results are shown in Table 5 below.

The test results are shown in Table 5. The extruded granules of the present invention showed high control activity against Chilo suppressalis (dominant species) over a long period of time compared to the mobile formulation.

(Test Example 4 Field test against brown fly) The granules of Preparation Example 1 (extrusion type granules) were mixed with an appropriate amount of sand, and then applied uniformly to the rice field 25 days after transplantation in such a manner that the original volume became a specified volume (field surface water treatment). On the same day, the flowable agent of Comparative Preparation Example 1 was diluted with water in such a manner that the treatment water volume became 40L/10a, and then sprayed on the stems and leaves in such a manner that the original volume became a specified volume by a sprayer. No preparation was applied to the untreated area. Although no parasitism of rice by flies was observed during the preparation treatment, the number of adults and larvae of brown flies parasitizing on each plant head was visually counted 31, 49, and 56 days after treatment. The results of the survey of ³⁰ plants in a 25 m2 plot are shown in Table 6 below as the number of parasites per plant (total of adults and larvae).

The test results are shown in Table 6. The extruded granules of the present invention showed high control activity against brown plant flies even after a long period of time compared to the liquid formulation.

(Reference Test Example Comparative Test of Granular Hydrator and Flowing Agent) The flowing agent of Comparative Preparation Example 1 or the granular hydrate of Comparative Preparation Example 2 was diluted with water in a treatment water volume of 150L/10a, and the original volume was made into a specified amount, and then sprayed on the rice stems and leaves 48 days after transplantation by a sprayer. For the untreated area, no preparation was applied. Before each treatment and 4, 7, 19, and 33 days after the treatment, the fly species parasitizing on each plant head were wiped off on an A4-sized sticky board, and the number of gray fly adults and larvae was counted visually. The results of the survey of 30 plants in a 24 ^m2 plot are shown in Table 7 below as the number of parasites per plant (total of adults and larvae).

The test results, as shown in Table 7, show that the flowable agent and the granular hydrate agent show the same degree of control activity against gray fly flies. Therefore, based on the above results, it can be said that the extruded granules of the present invention show high control activity over a long period of time compared with the granular hydrate. [Industrial Applicability]

As described above, according to the present invention, a novel solid formulation for controlling harmful organisms, especially rice pests, with a long duration of control activity, a rice pest control method using the same, and a method for producing the solid formulation for controlling rice pests can be provided. For example, the solid formulation for controlling rice pests of the present invention can be used to treat field water 2 to 5 weeks after rice transplantation, so that flies and rice stem borers that could not be fully controlled by a single treatment of pesticides can be controlled at one time, which can effectively reduce the labor of pesticide control applied to rice farmers and improve the yield rate.

Claims (17)

A solid preparation for controlling rice pests, comprising at least one active ingredient selected from the group consisting of flupyrimin and its salts represented by the following formula (1), a solid carrier, a surfactant, and a binder, and is a coated granule or an extruded granule.

For example, the solid preparation for controlling rice pests in claim 1 is a coated granule, and the solid carrier comprises core particles and an extender. For example, in the solid preparation for controlling rice pests as in claim 2, the particle size of the core particles is 63μm~6mm. For example, in the solid preparation for controlling rice pests as claimed in claim 2 or 3, the core particles are at least one selected from the group consisting of silica sand, granular calcium carbonate, diatomaceous earth particles, granular clay and pumice. For example, the solid preparation for controlling rice pests as claimed in claim 2 or 3, wherein the aforementioned extender is at least one selected from the group consisting of clay, calcium carbonate, kaolin and silicon dioxide. For example, the solid preparation for controlling rice pests as claimed in claim 2 or 3, wherein the aforementioned binder is at least one selected from the group consisting of liquid paraffin, vegetable oil, polyethylene glycol and polypropylene glycol. For example, the solid preparation for controlling rice pests in claim 1 is an extruded granule, the solid carrier includes an extender, and the surfactant includes a granulation improver and a disintegrating and/or dispersing agent. For example, the solid preparation for controlling rice pests of claim 7, wherein the aforementioned extender is at least one selected from the group consisting of clay, talc, calcium carbonate, kaolin, silicon dioxide and bentonite. A solid preparation for controlling rice pests as claimed in claim 7 or 8, wherein the granulation improving agent is at least one selected from the group consisting of sodium lauryl sulfate, sodium dialkyl sulfosuccinate and sodium alkylbenzene sulfonate. For example, the solid preparation for controlling rice pests of claim 7 or 8, wherein the aforementioned disintegrating and/or dispersing agent is at least one selected from the group consisting of sodium lignin sulfonate, calcium lignin sulfonate, sodium naphthalene sulfonate formalin condensate, sodium polyacrylate, polyoxyethylene alkyl ether sodium sulfate, polyoxyalkylene styrene phenyl ether sodium sulfate, polyoxyalkylene styrene phenyl ether sodium phosphate and polyoxyethylene polyoxypropylene polymer sodium sulfate. A solid preparation for controlling rice pests as claimed in claim 7 or 8, wherein the binder is at least one selected from the group consisting of polyvinyl alcohol, dextrin, sugars, sodium carboxymethylcellulose, hydroxypropylmethylcellulose and methylcellulose. A method for controlling rice pests, comprising the step of applying an effective amount of a solid preparation for controlling rice pests as described in any one of claims 1 to 11 to at least one selected from the group consisting of rice pests, rice, soil and field water surface. The rice pest control method of claim 12, wherein the rice pest is at least one selected from the group consisting of flies and rice stem borers. A rice pest control method as claimed in claim 12 or 13, wherein the rice pest is a pesticide-resistant pest. For example, the rice pest control method of claim 12 or 13, wherein the effective amount of the solid preparation for rice pest control is 1g~1kg per 10 hectares of cultivated land, calculated as the amount of the active ingredient. A method for producing a solid preparation for controlling rice pests, which is a method for producing a solid preparation for controlling rice pests as claimed in any one of claims 2 to 6, characterized by comprising: a wetting step of adding the aforementioned binder, or the aforementioned binder and the aforementioned surfactant to the aforementioned core particles to make them wet, to obtain wet core particles, a mixing and grinding step of mixing the aforementioned active ingredient, the aforementioned surfactant and the aforementioned extender, or the aforementioned active ingredient and the aforementioned extender and grinding them to obtain a first mixed and ground product, and a step of mixing the aforementioned wet core particles with the first mixed and ground product to obtain a coated granule in which the surface of the aforementioned wet core particles is coated with the first mixed and ground product. A method for producing a solid preparation for controlling rice pests, which is a method for producing a solid preparation for controlling rice pests as claimed in any one of claims 7 to 11, characterized in that it comprises: mixing the aforementioned active ingredient, the aforementioned extender and the aforementioned binder and pulverizing, or mixing the aforementioned active ingredient, the aforementioned extender, the aforementioned binder, the aforementioned granulation improving agent and the aforementioned disintegration and/or dispersing agent and pulverizing, or mixing the aforementioned active ingredient, the aforementioned extender and the aforementioned binder, the aforementioned granulation improving agent and the aforementioned disintegration and/or dispersing agent and pulverizing. The invention further comprises a step of mixing and pulverizing the first mixed material and the second mixed material, and a step of kneading the second mixed material and water, or kneading the second mixed material, water, the granulation improver and the disintegration and/or dispersant, or kneading the second mixed material and water, and the granulation improver or the disintegration and/or dispersant to obtain a kneaded product, and a step of molding the kneaded product with an extrusion granulator to obtain extruded granules.