TWI765389B - Local subcutaneous microcirculation detection device - Google Patents

Abstract

A local subcutaneous microcirculation detection device including a first light source module, a second light source module, a lens plate, a first light sensor, and a second light sensor is provided. The first light source module is configured to emit a first illumination beam, and the second light source module is configured to emit a second illumination beam. The lens plate has a flat plate portion and a first convex lens portion. The flat plate portion is configured to lean against a first portion of skin of a subject, and a convex surface of the first convex lens portion is configured to push into a second portion of the skin of the subject. The first illumination beam is reflected into a second reflected beam by the first portion of the skin. The second illumination beam is reflected into a second reflected beam by the second portion of the skin. The first reflected beam is transmitted to the first light sensor. The second reflected beam is transmitted to the second light sensor.

Description

Local subcutaneous microvascular circulation detection device

The present invention relates to an optical detection device, and more particularly, to a local subcutaneous microvascular circulation detection device.

Crushing is a common skin disease in bedridden patients with inconvenience of movement. It is mainly caused by prolonged stress on the skin, resulting in vascular skin lesions and eventually open wounds.

In the early stage of the disease, the compressed blood vessels produce lesions, which reduces the ability to supply nutrients to the skin tissue and take away the waste generated after metabolism. Over time, the skin tissue will be necrotic. Open wounds after tissue necrosis increase the difficulty of care, increase the mortality rate of patients, and cause a substantial increase in household expenditure and care costs.

At present, the clinical "skin whitening test" is the most reliable test method to identify early pressure injuries. It is mainly determined by professional medical staff pressing the skin to observe the amount of blood returned. However, the clinical skin whitening test cannot be applied to the field of home care, and it is difficult to observe the whitening of the skin with the naked eye for patients with dark skin. In addition, even if the skin whitening test is performed by professional medical staff, it is also judged by naked eye observation and experience, which cannot be quantitatively measured.

The invention provides a local subcutaneous microvascular circulation detection device, which can quantitatively measure the local subcutaneous microvascular circulation of a subject.

An embodiment of the present invention provides a local subcutaneous microvascular circulation detection device, which includes a first light source module, a second light source module, a lens plate, a first light sensor and a second light sensor. The first light source module is used for emitting a first illumination beam, and the second light source module is used for emitting a second illumination beam. The lens plate has a flat plate portion and a first convex lens portion. The flat plate part is used for bearing on a first part of the skin of a subject, and a convex surface of the first convex lens part is used for pressing into a second part of the skin of a subject. The first illumination beam is reflected by the first part of the skin into a first reflected beam after penetrating the flat plate part, and the second illumination beam is reflected by the second part of the skin into a second reflected beam after penetrating the first convex lens part. The first reflected light beam is transmitted to the first photo sensor after passing through the flat plate portion, and the second reflected light beam is transmitted to the second photo sensor after passing through the first convex lens portion.

An embodiment of the present invention provides a local subcutaneous microvascular circulation detection device, which includes a light reflection housing, a first light source module, a second light source module, a lens plate, a first light sensor, and a first light source Two light sensors. The light reflecting shell has a first light integration space and a second light integration space separated from each other. The first light source module is disposed in the first light integration space, and is used for emitting a first illumination beam transmitted in the first light integration space. The second light source module is disposed in the second light integration space, and is used for emitting a second illumination beam transmitted in the second light integration space. The lens plate has a flat plate portion and a first convex lens portion, which are respectively arranged at one end of the first light integration space and one end of the second light integration space. The flat plate part is used for bearing on a first part of the skin of a subject, and a convex surface of the first convex lens part is used for pressing into a second part of the skin of a subject. The first illumination beam is reflected by the first part of the skin into a first reflected beam after penetrating the flat plate part, and the second illumination beam is reflected by the second part of the skin into a second reflected beam after penetrating the first convex lens part. The first reflected light beam passes through the flat plate portion and is transmitted to the first light sensor through the first light integration space, and the second reflected light beam passes through the first convex lens portion and is transmitted to the second light sensor through the second light integration space.

In the local subcutaneous microvascular circulation detection device according to the embodiment of the present invention, a lens plate having a flat plate portion and a first convex lens portion is used to perform non-pressing and pressing actions on the skin, and the first light source module, the first light source module and the first convex lens are used. A light sensor, a second light source module and a second light sensor are used for optical detection of the skin that is not pressed and pressed, respectively. In this way, the local subcutaneous microvascular circulation detection device of the embodiment of the present invention can quantitatively measure the local subcutaneous microvascular circulation of the subject.

1 is a schematic cross-sectional view of a local subcutaneous microvascular circulation detection device according to an embodiment of the present invention, FIG. 2 is a cross-sectional schematic view of the lens plate in FIG. 1 , and FIG. 3 is a schematic front view of the light source module in FIG. 1 . Referring to FIGS. 1 , 2 and 3 , the local subcutaneous microvascular circulation detection device 100 of this embodiment includes a light reflecting housing 110 , a first light source module 120 , a second light source module 130 , and a lens plate 140 , a first light sensor 150 and a second light sensor 160 . The light reflection housing 110 has a first light integration space S1 and a second light integration space S2 separated from each other. The first light source module 120 is disposed in the first light integration space S1, and is used for emitting a first illumination light beam I1 transmitted in the first light integration space S1. The second light source module 130 is disposed in the second light integration space S2, and is used for emitting a second illumination beam I2 transmitted in the second light integration space S2. In this embodiment, the light reflection housing 110 includes a housing 112 and a reflection partition 114, wherein the reflection partition 114 separates the first light integration space S1 and the second light integration space S2. A part of the housing 112 and the reflective partition 114 surround the first light integration space S1 , and another part of the housing 112 and the reflection partition 114 surround the second light integration space S2 .

In this embodiment, the light reflection housing 110 diffusely reflects the first illumination beam I1 in the first light integration space S1, and diffusely reflects the second illumination beam I2 in the second light integration space S2. That is to say, both the housing 112 and the reflective baffle 114 have diffuse reflection surfaces, which can diffusely reflect the first illumination beam I1 and the second illumination beam I2, and the first illumination beam I1 does not enter the second light integration space S2, and The second illumination beam I2 also does not enter the first light integration space S1.

The lens plate 140 has a flat plate portion 142 and a first convex lens portion 144, which are respectively disposed at one end of the first light integration space S1 and one end of the second light integration space S2. The flat plate portion 142 is used to bear against a first portion P1 of the subject's skin 50 , and a convex surface 145 of the first convex lens portion 144 is used to press into a second portion P2 of the subject's skin 50 . In one embodiment, the focal length of the first convex lens portion 144 is, for example, 2 mm. The first illumination beam I1 penetrates the flat plate portion 142 and is reflected by the first portion P1 of the skin 50 into a first reflected beam R1, and the second illumination beam I2 penetrates the first convex lens portion 144 and is reflected by the second portion P2 of the skin 50 into a first reflected beam R1. Two reflected beams R2. The first reflected light beam R1 passes through the flat plate portion 142 and is transmitted to the first light sensor 150 through the first light integration space S1 , and the second reflected light beam R2 passes through the first convex lens portion 144 and passes through the second light integration space S2 to be transmitted to the first light sensor 150 . The second light sensor 160 .

In this embodiment, the light reflection casing 110 also makes the first reflected light beam R1 diffusely reflect in the first light integration space S1, and the second reflected light beam R2 is diffusely reflected in the second light integration space S2. That is to say, the housing 112 and the reflective baffle 114 both have diffuse reflection surfaces, which can diffusely reflect the first reflected light beam R1 and the second reflected light beam R2, and the first reflected light beam R1 will not enter the second light integration space S2, and The second reflected light beam R2 also does not enter the first light integration space S1. Through the light integration effect of the light reflection housing 110 , the light intensities of the first reflected light beam R1 and the second reflected light beam R2 sensed by the first light sensor 150 and the second light sensor 160 respectively can be effectively elevated.

In this embodiment, the first light source module 120 includes a first light-emitting element 122 , a second light-emitting element 124 and a third light-emitting element 126 (as shown in FIG. 3 ), and the second light source module 130 includes A fourth light emitting element 132 , a fifth light emitting element 134 and a sixth light emitting element 136 . The first light-emitting element 122 is used for emitting a first sub-illumination beam B1, the second light-emitting element 124 is used for emitting a second sub-illumination beam B2, and the third light-emitting element 126 is used for emitting a third sub-illumination beam B3. The fourth light-emitting element 132 is used for emitting a fourth sub-illumination beam B4, the fifth light-emitting element 134 is used for emitting a fifth sub-illumination beam B5, and the sixth light-emitting element 136 is used for emitting a sixth sub-illumination beam B6. The first sub-illumination beam B1 and the fourth sub-illumination beam B4 have a first wavelength, the second sub-illumination beam B2 and the fifth sub-illumination beam B5 have a second wavelength, and the third sub-illumination beam B3 and the sixth sub-illumination beam B6 has a third wavelength. The first sub-illumination beam B1, the second sub-illumination beam B2, and the third sub-illumination beam B3 form the first illumination beam I1, and the fourth sub-illumination beam B4, the fifth sub-illumination beam B5, and the sixth sub-illumination beam B6 form the first sub-illumination beam I1. Two illumination beams I2.

In this embodiment, the first light-emitting element 122 , the second light-emitting element 124 and the third light-emitting element 126 are used to emit the first sub-illumination beam B1 , the second sub-illumination beam B2 and the third sub-illumination beam B3 in turn, and the skin 50 The first part P1 takes turns and reflects the first sub-illumination beam B1, the second sub-illumination beam B2 and the third sub-illumination beam B3 into a first sub-reflection beam RS1, a second sub-reflection beam RS2 and a third sub-reflection beam respectively beam RS3, and the first photo sensor 150 alternately detects the first sub-reflected beam RS1, the second sub-reflected beam RS2 and the third sub-reflected beam RS3 at different times.

The fourth light-emitting element 132, the fifth light-emitting element 134 and the sixth light-emitting element 136 are used to emit the fourth sub-illumination beam B4, the fifth sub-illumination beam B5 and the sixth sub-illumination beam B6 in turn, and the second part P2 of the skin 50 takes turns in turn And the fourth sub-illumination beam B4, the fifth sub-illumination beam B5 and the sixth sub-illumination beam B6 are respectively reflected into a fourth sub-reflection beam RS4, a fifth sub-reflection beam RS5 and a sixth sub-reflection beam RS6, and the The two photo sensors 160 alternately sense the fourth sub-reflected beam RS4, the fifth sub-reflected beam RS5 and the sixth sub-reflected beam RS6 at different times.

In this embodiment, the first light-emitting element 122, the second light-emitting element 124, the third light-emitting element 126, the fourth light-emitting element 132, the fifth light-emitting element 134 and the sixth light-emitting element 136 are, for example, light-emitting diodes. However, In other embodiments, it can also be a laser diode or other light-emitting element. In addition, in this embodiment, the first photo sensor 150 and the second photo sensor 160 are, for example, photodiodes, however, in other embodiments, they may also be other photo sensors device.

In this embodiment, oxygenated hemoglobin and hemoglobin in the blood of the subject's skin 50 have the same absorption coefficient for the light of the second wavelength, and the oxygenated hemoglobin and hemoglobin absorb the light of the first wavelength and the third wavelength. The coefficients show an opposite trend with the amount of oxygen concentration. For example, the first wavelength is 740 nm, the second wavelength is 808 nm, and the third wavelength is 850 nm, all of which belong to the infrared light band. Specifically, light can travel and travel in biological tissue depending on the scattering coefficient of the tissue, so we choose light-emitting elements with similar wavelengths so that the three wavelengths travel relatively the same path in the tissue. These wavelengths were chosen because the central wavelength of the 808 nm light emitting diode has the same absorption coefficient of light in oxyhemoglobin and hemoglobin, and the reflected light intensity at this wavelength does not change with the oxygen saturation concentration of hemoglobin and oxyhemoglobin, Changes in the amount of blood in the tissue alone cause changes in the reflected light at 808 nm. The absorption coefficient between oxyhemoglobin and hemoglobin at 740 nm and 850 nm shows an opposite trend to the amount of oxygen concentration, so it can have a higher resolution for the change of oxygen concentration. Using these three wavelengths can easily quantify the blood volume and oxygen concentration in the tissue, and the near-infrared light in this band is called the tissue window, because other than blood, the absorption of other substances in the skin tissue is very small, which can The information that senses more blood vessels can also be more suitable for patients with dark skin tones. This is because the subcutaneous tissue of most dark skin often makes it difficult for doctors to judge the color change caused by the blood change after the finger is pressed.

In this embodiment, the local subcutaneous microvascular circulation detection device 100 further includes a controller 190 electrically connected to the first light source module 120 , the second light source module 130 , the first light sensor 150 and the second light sensor The detector 160 is used to calculate the difference between the light intensity of the first reflected light beam R1 and the second reflected light beam R2 sensed by the first light sensor 150 and the second light sensor 160 to calculate the extrusion caused by the convex surface 145 The difference in absorbance caused by the blood of the second portion P2 of the skin 50 . In addition, the controller 190 can also calculate the oxygen concentration of the blood of the skin 50 according to the light intensity difference between the first reflected light beam R1 and the second reflected light beam R2.

（相當於不按壓皮膚50所測得的光強度）與第二光感測器160所感測到的光強度

（相當於透過第一凸透鏡部144的凸面145按壓皮膚50所測得的光強度），來計算出因第一凸透鏡部144擠出的血液所造成的吸光度的差異

，而其計算方式如下式： Specifically, the controller 190 can use the light intensity sensed by the first light sensor 150

(equivalent to the light intensity measured without pressing the skin 50 ) and the light intensity sensed by the second light sensor 160

(corresponding to the light intensity measured by pressing the skin 50 through the convex surface 145 of the first convex lens portion 144 ) to calculate the difference in absorbance caused by the blood squeezed out by the first convex lens portion 144

, and its calculation is as follows:

…式(1)

…Formula 1)

與第二光感測器160所測得的第四子反射光束RS4的光強度

可分別代入式(1)中的

與

而得到對應於第一波長的吸光度差異

。同理，第一光感測器150所測得的第二子反射光束RS2的光強度

與第二光感測器160所測得的第五子反射光束RS5的光強度

可分別代入式(1)中的

與

而得到對應於第二波長的吸光度差異

。此外，第一光感測器150所測得的第三子反射光束RS3的光強度

與第二光感測器160所測得的第六子反射光束RS6的光強度

可分別代入式(1) 中的

與

而得到對應於第三波長的吸光度差異

。 Since the first reflected light beam R1 and the second reflected light beam R2 each have sub-beams with three different wavelengths, the light intensity of the first sub-reflected light beam RS1 measured by the first photo sensor 150

and the light intensity of the fourth sub-reflection beam RS4 measured by the second light sensor 160

can be substituted into formula (1) respectively

and

and the difference in absorbance corresponding to the first wavelength is obtained

. Similarly, the light intensity of the second sub-reflection beam RS2 measured by the first optical sensor 150

and the light intensity of the fifth sub-reflected beam RS5 measured by the second light sensor 160

can be substituted into formula (1) respectively

and

and the difference in absorbance corresponding to the second wavelength is obtained

. In addition, the light intensity of the third sub-reflection beam RS3 measured by the first light sensor 150

and the light intensity of the sixth sub-reflection beam RS6 measured by the second light sensor 160

can be substituted into formula (1) respectively

and

and the difference in absorbance corresponding to the third wavelength is obtained

.

代入修正後的比爾定律（Beer’s law）公式而得到三個方程式，並求解此三個聯立方程式而得到帶氧血紅蛋白濃度l _HbO2與血紅蛋白濃度l _Hb。上述修正後的比爾定律公式如下： Next, the controller 190 can calculate the above three absorbance differences calculated by using the light intensities of the three different wavelengths

Substitute into the revised Beer's law formula to obtain three equations, and solve the three simultaneous equations to obtain the oxygenated hemoglobin concentration l _HbO2 and the hemoglobin concentration l _Hb . The above modified Beer's Law formula is as follows:

…式(2)

...formula (2)

來修改比爾定律方程，以匹配不透明樣品中的吸光度變化。在式(2)中，

、

及

是常數，將上述對應於三種不同波長的

值代入式(2)後，可得到三個方程式，聯立求解後恰可解出帶氧血紅蛋白濃度l _HbO2、血紅蛋白濃度l _Hb以及散射的影響程度l _s這三個未知數。 The modified Beer's Law formulation of Equation (2) is used to quantify the contribution of oxyhemoglobin and hemoglobin. The original Beer's Law is a fundamental tool for distinguishing the absorbance of different chromophores in translucent sample solutions. Since biological tissue is often opaque and has strong light scattering properties, baseline shifts are often found in tissue absorption spectra. Therefore, a scattering term can be added

to modify the Beer's Law equation to match absorbance changes in opaque samples. In formula (2),

,

and

is a constant, the above corresponding to three different wavelengths

After substituting the value into formula (2), three equations can be obtained, and the three unknowns of the oxygenated hemoglobin concentration l _HbO2 , the hemoglobin concentration l _Hb and the influence degree of scattering l _s can be solved after simultaneous solution.

After the controller 190 obtains the oxygenated hemoglobin concentration l _HbO2 and the hemoglobin concentration l _Hb , it can further obtain the blood volume ΔBlood that changes due to pressing caused by the pressing of the skin 50 by the first convex lens portion 144 according to the following formula (3), wherein: Formula (3) is as follows:

…式(3)

...formula (3)

In addition, the controller 190 can also calculate the blood oxygen saturation concentration SBO ₂ % of the pressed skin 50 according to the obtained oxygenated hemoglobin concentration l _{HbO 2} and hemoglobin concentration l _Hb and the following formula (4), wherein Formula (4) is as follows:

…式(4)

...Formula (4)

By calculating from equations (1) to (4) by the controller 190, the state of the local subcutaneous microvascular circulation generated by the first convex lens portion 144 pressing the skin 50 can be quantified, which can be used as a detection basis for the initial pressure injury, which The reliability of the detection results is higher than that of the skin whitening test observed with the naked eye, and there is no situation where it is difficult to observe the skin whitening due to the darker skin of the subject.

In addition, because the skin tissue has high scattering properties, after the light enters the tissue, the reflected light will be scattered in all directions through the skin surface. In order to accurately collect the light reflection signals of all the skin 50 at the pressed and non-pressed places, and the two sides do not interfere with each other, this embodiment adopts the light reflection shell 110 to form a small integration space with one cavity and two chambers, which is placed in a specially designed Above the lens plate 140 , the reflected light from the respective skins 50 is collected. The two chambers (ie, the first light integration space S1 and the second light integration space S2) each have the same special three kinds of near-infrared light-emitting elements with different wavelengths and photodiode light sensors, and these elements are placed on the same plane , to ensure that the light emitted by the light source does not directly enter the photodiode light sensor, but must be absorbed by the skin 50 and then reflected before being sensed.

In one embodiment, the controller 190 is, for example, a central processing unit (CPU), a microprocessor (microprocessor), a digital signal processor (DSP), a programmable controller, a programmable controller, or a programmable controller. A logic device (programmable logic device, PLD) or other similar devices or a combination of these devices is not limited by the present invention. Additionally, in one embodiment, each function of the controller 190 may be implemented as multiple codes. These codes are stored in a memory and are executed by the controller 190 . Alternatively, in one embodiment, the functions of controller 190 may be implemented as one or more circuits. The present invention does not limit the implementation of the functions of the controller 190 by means of software or hardware.

4 is a schematic cross-sectional view of a local subcutaneous microvascular circulation detection device according to another embodiment of the present invention. Referring to FIG. 4 , the local subcutaneous microvascular circulation detection device 100 a of the present embodiment is similar to the local subcutaneous microvascular circulation detection device 100 in FIG. 1 , and the differences between the two are as follows. The local subcutaneous microvascular circulation detection device 100a of this embodiment further includes a third light source module 170 and a third light sensor 180 , and the lens plate 140a further includes a second convex lens portion 146 . The relative positional relationship of the third light source module 170 , the third light sensor 180 and the second convex lens portion 146 is the same as the relative positional relationship of the second light source module 130 , the second light sensor 160 and the first convex lens portion 144 , but the thickness T2 of the second convex lens portion 146 is different from the thickness T1 of the first convex lens portion 144 . The third light source module 170 and the third light sensor 180 and their operation methods can be the same as or similar to the operation methods of the second light source module 130 and the second light sensor 160, and they can also emit and detect three different wavelength of light, and the third light source module 170 and the third photo sensor 180 are also electrically connected to the controller 190 to be controlled by the controller 190 , and the controller 190 can The measured values are calculated.

The third light source module 170 and the third light sensor 180 may have a corresponding third light integration space S3, which is separated from the first light integration space S1 by the reflection partition 114a of the light reflection housing 110a, and is separated by the reflection partition 114a of the light reflection housing 110a. The reflection partition 114b of the light reflection housing 110a is separated from the second light integration space S2.

Due to the difference in thickness between the second convex lens portion 146 and the first convex lens portion 144 , different degrees of indentation can be produced on the skin 50 , thereby making more comprehensive and accurate measurements of the state of local subcutaneous microvascular circulation. In other embodiments, the lens plate can have more convex lens parts with different thicknesses, and the local subcutaneous microvascular circulation detection device can have more groups of light source modules and light sensors, which can produce more than or equal to 3 kinds of light sources on the skin. The degree of intrusion is measured and measured to make more oriented and accurate measurements of the state of local subcutaneous microvascular circulation.

To sum up, in the local subcutaneous microvascular circulation detection device according to the embodiment of the present invention, a lens plate having a flat plate portion and a first convex lens portion is used to perform non-pressing and pressing actions on the skin, and the first The light source module, the first light sensor, the second light source module and the second light sensor are used for optical detection of the skin that is not pressed and pressed, respectively. In this way, the local subcutaneous microvascular circulation detection device of the embodiment of the present invention can quantitatively measure the local subcutaneous microvascular circulation of the subject.

50: Skin 100: Local subcutaneous microvascular circulation detection device 110, 110a: light reflection shell 112: Shell 114, 114a, 114b: reflective baffles 120: The first light source module 122: The first light-emitting element 124: The second light-emitting element 126: The third light-emitting element 130: Second light source module 132: Fourth light-emitting element 134: Fifth light-emitting element 136: sixth light-emitting element 140, 140a: lens plate 142: Flat panel 144: First convex lens part 145: Convex 146: Second convex lens part 150: first light sensor 160: Second light sensor 170: The third light source module 180: Third light sensor 190: Controller B1: The first sub-illumination beam B2: Second sub-illumination beam B3: The third sub-illumination beam B4: Fourth sub-illumination beam B5: Fifth sub-illumination beam B6: Sixth sub-illumination beam I1: The first illumination beam I2: Second illumination beam P1: Part 1 P2: Part II R1: First reflected beam R2: Second reflected beam RS1: The first sub-reflected beam RS2: Second sub-reflected beam RS3: The third sub-reflected beam RS4: Fourth sub-reflected beam RS5: Fifth sub-reflected beam RS6: Sixth sub-reflected beam S1: The first light integration space S2: Second light integration space S3: The third light integration space T1, T2: Thickness

FIG. 1 is a schematic cross-sectional view of a local subcutaneous microvascular circulation detection device according to an embodiment of the present invention. FIG. 2 is a schematic cross-sectional view of the lens plate in FIG. 1 . FIG. 3 is a schematic front view of the light source module in FIG. 1 . 4 is a schematic cross-sectional view of a local subcutaneous microvascular circulation detection device according to another embodiment of the present invention.

50: Skin 100: Local subcutaneous microvascular circulation detection device 110: Light reflection shell 112: Shell 114: Reflective baffle 120: The first light source module 130: Second light source module 140: Lens plate 142: Flat panel 144: First convex lens part 145: Convex 150: first light sensor 160: Second light sensor 190: Controller B1: The first sub-illumination beam B2: Second sub-illumination beam B3: The third sub-illumination beam B4: Fourth sub-illumination beam B5: Fifth sub-illumination beam B6: Sixth sub-illumination beam I1: The first illumination beam I2: Second illumination beam P1: Part 1 P2: Part II R1: First reflected beam R2: Second reflected beam RS1: The first sub-reflected beam RS2: Second sub-reflected beam RS3: The third sub-reflected beam RS4: Fourth sub-reflected beam RS5: Fifth sub-reflected beam RS6: Sixth sub-reflected beam S1: The first light integration space S2: Second light integration space

Claims (15)

A local subcutaneous microvascular circulation detection device, comprising: a first light source module for emitting a first illumination beam; a second light source module for emitting a second illumination beam; a lens plate with a flat plate portion and a first convex lens portion, wherein the flat plate portion is used to bear against a first portion of a skin of a subject, a convex surface of the first convex lens portion is used to press into a second portion of the skin, the The first illumination beam is reflected by the first part of the skin into a first reflection beam after penetrating the flat plate part, and the second illumination beam is reflected by the second part of the skin into a second reflection beam after penetrating the first convex lens part a light beam; a first light sensor, wherein the first reflected light beam penetrates the flat plate portion and is transmitted to the first light sensor; a second light sensor, wherein the second reflected light beam penetrates the first light beam A convex lens portion is then transmitted to the second light sensor; and a controller is electrically connected to the first light source module, the second light source module, the first light sensor and the second light sensor a detector for calculating the first part of the skin according to the light intensity difference between the first reflected light beam and the second reflected light beam sensed by the first light sensor and the second light sensor Absorbance difference from this second fraction. The local subcutaneous microvascular circulation detection device as claimed in claim 1, further comprising a light reflection housing having a reflection partition to separate a first light integration space and a second light integration space, wherein the first light source modulates set with the first photosensor Located in the first light integration space, the second light source module and the second light sensor are located in the second light integration space. The local subcutaneous microvascular circulation detection device as claimed in claim 2, wherein the light reflecting shell makes the first illumination beam and the first reflection beam diffusely reflect in the first light integration space, and makes the second illumination beam diffuse Diffuse reflection with the second reflected light beam in the second light integration space. The local subcutaneous microvascular circulation detection device according to claim 1, wherein the first light source module comprises: a first light-emitting element for emitting a first sub-illumination beam; a second light-emitting element for emitting a first light-emitting element Two sub-illumination beams; and a third light-emitting element for emitting a third sub-illumination beam, and the second light source module includes: a fourth light-emitting element for emitting a fourth sub-illumination beam; a fifth a light-emitting element for emitting a fifth sub-illumination beam; and a sixth light-emitting element for emitting a sixth sub-illumination beam, wherein the first sub-illumination beam and the fourth sub-illumination beam have a first wavelength, The second sub-illumination beam and the fifth sub-illumination beam have a second wavelength, the third sub-illumination beam and the sixth sub-illumination beam have a third wavelength, the first sub-illumination beam, the second sub-illumination beam The light beam and the third sub-illumination beam form the first illumination beam, and the fourth sub-illumination beam, the fifth sub-illumination beam, and the sixth sub-illumination beam form the second illumination beam. The local subcutaneous microvascular circulation detection device according to claim 4, wherein the first wavelength is 740 nm, the second wavelength is 808 nm, and the third wavelength is 850 nm. The local subcutaneous microvascular circulation detection device according to claim 4, wherein the first light-emitting element, the second light-emitting element and the third light-emitting element are used to emit the first sub-illumination beam, the second sub-illumination beam and For the third sub-illumination beam, the first part of the skin alternately reflects the first sub-illumination beam, the second sub-illumination beam and the third sub-illumination beam into a first sub-reflection beam and a second sub-reflection beam, respectively light beam and a third sub-reflection beam, and the first light sensor detects the first sub-reflection beam, the second sub-reflection beam and the third sub-reflection beam in turn, the fourth light-emitting element, the fifth The light-emitting element and the sixth light-emitting element are used to emit the fourth sub-illumination beam, the fifth sub-illumination beam and the sixth sub-illumination beam in turn, and the second part of the skin takes turns and respectively the fourth sub-illumination beam , the fifth sub-illumination beam and the sixth sub-illumination beam are reflected into a fourth sub-reflection beam, a fifth sub-reflection beam and a sixth sub-reflection beam, and the second light sensor detects the fourth sub-beam in turn the sub-reflection beam, the fifth sub-reflection beam and the sixth sub-reflection beam. The local subcutaneous microvascular circulation detection device according to claim 1, wherein the controller further calculates the blood oxygen concentration of the skin according to the difference in light intensity between the first reflected beam and the second reflected beam. The local subcutaneous microvascular circulation detection device according to claim 1, further comprising a third light source module and a third light sensor, wherein the lens plate further has a second convex lens portion, the third light source module, the third photo sensor and the second convex The relative positional relationship of the lens portion is the same as the relative positional relationship of the second light source module, the second light sensor and the first convex lens portion, but the thickness of the second convex lens portion is different from that of the first convex lens portion. A local subcutaneous microvascular circulation detection device, comprising: a light reflection shell, with a first light integration space and a second light integration space separated from each other; a first light source module, arranged in the first light integration space , and is used to emit a first illumination beam transmitted in the first light integration space; a second light source module is disposed in the second light integration space and used to emit in the second light integration space A second illumination beam transmitted; a lens plate with a flat plate portion and a first convex lens portion, respectively disposed at one end of the first light integration space and one end of the second light integration space, wherein the flat plate portion is used for Bearing on a first part of a skin of a subject, a convex surface of the first convex lens part is used to press into a second part of the skin, the first illumination beam penetrates the flat plate part and is absorbed by the skin The first part of the skin is reflected into a first reflected beam, and the second illumination beam penetrates the first convex lens part and is reflected by the second part of the skin into a second reflected beam; a first light sensor, wherein the first light beam A reflected light beam penetrates the flat plate portion and is transmitted to the first light sensor through the first light integration space; a second light sensor, wherein the second reflected light beam penetrates the first convex lens portion and then passes through the first light sensor The second light integration space is transmitted to the second light sensor; and a controller is electrically connected to the first light source module, the second light source module, The first light sensor and the second light sensor are used for the first reflected light beam and the second reflected light beam sensed by the first light sensor and the second light sensor The difference in light intensity is used to calculate the difference in absorbance between the first part and the second part of the skin. The local subcutaneous microvascular circulation detection device according to claim 9, wherein the light-reflecting housing makes the first illumination beam and the first reflected beam diffusely reflect in the first light integration space, and makes the second illumination beam Diffuse reflection with the second reflected light beam in the second light integration space. The local subcutaneous microvascular circulation detection device according to claim 9, wherein the first light source module comprises: a first light-emitting element for emitting a first sub-illumination beam; a second light-emitting element for emitting a first light-emitting element Two sub-illumination beams; and a third light-emitting element for emitting a third sub-illumination beam, and the second light source module includes: a fourth light-emitting element for emitting a fourth sub-illumination beam; a fifth a light-emitting element for emitting a fifth sub-illumination beam; and a sixth light-emitting element for emitting a sixth sub-illumination beam, wherein the first sub-illumination beam and the fourth sub-illumination beam have a first wavelength, The second sub-illumination beam and the fifth sub-illumination beam have a second wavelength, the third sub-illumination beam and the sixth sub-illumination beam have a third wavelength, the first sub-illumination beam, the second sub-illumination beam The light beam and the third sub-illumination beam form the first illumination beam, and the fourth sub-illumination beam, the fifth sub-illumination beam and the sixth sub-illumination beam The bright light beam forms the second illumination light beam. The local subcutaneous microvascular circulation detection device of claim 11, wherein the first wavelength is 740 nm, the second wavelength is 808 nm, and the third wavelength is 850 nm. The local subcutaneous microvascular circulation detection device as claimed in claim 11, wherein the first light-emitting element, the second light-emitting element and the third light-emitting element are used to alternately emit the first sub-illumination beam, the second sub-illumination beam and For the third sub-illumination beam, the first part of the skin alternately reflects the first sub-illumination beam, the second sub-illumination beam and the third sub-illumination beam into a first sub-reflection beam and a second sub-reflection beam, respectively light beam and a third sub-reflection beam, and the first light sensor detects the first sub-reflection beam, the second sub-reflection beam and the third sub-reflection beam in turn, the fourth light-emitting element, the fifth The light-emitting element and the sixth light-emitting element are used to emit the fourth sub-illumination beam, the fifth sub-illumination beam and the sixth sub-illumination beam in turn, and the second part of the skin takes turns and respectively the fourth sub-illumination beam , the fifth sub-illumination beam and the sixth sub-illumination beam are reflected into a fourth sub-reflection beam, a fifth sub-reflection beam and a sixth sub-reflection beam, and the second light sensor detects the fourth sub-beam in turn the sub-reflection beam, the fifth sub-reflection beam and the sixth sub-reflection beam. The local subcutaneous microvascular circulation detection device according to claim 9, wherein the controller further calculates the blood oxygen concentration of the skin according to the light intensity difference between the first reflected beam and the second reflected beam. The local subcutaneous microvascular circulation detection device according to claim 9, further comprising a third light source module and a third light sensor, wherein the lens plate is further There is a second convex lens part, and the relative positional relationship of the third light source module, the third photo sensor and the second convex lens part is the same as that of the second light source module, the second photo sensor and the first The relative positional relationship of a convex lens portion, but the thickness of the second convex lens portion is different from the thickness of the first convex lens portion.

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