TWI749074B - Apparatus for preparing cosmetic composition containing multiple-emulsion substance formed by instant emulsification using microfluidic channel - Google Patents

Abstract

An apparatus for preparing a cosmetic composition containing a multiple-emulsion substance includes a fluid container provided in a housing, the fluid container having an external-phase chamber for storing an external-phase fluid forming the external phase of an emulsion substance, and a dispersed-phase chamber for storing a dispersed-phase fluid forming the dispersed phase of the emulsion substance; and an outermost-phase chamber provided in the housing and for storing an outermost-phase fluid forming a multiple-emulsion substance by contacting the emulsion substance. The apparatus further includes a first channel for allowing the external-phase fluid to combine with the dispersed-phase fluid to form the emulsion substance; a second channel communicating with the first channel, the second channel being adapted to make the outermost-phase fluid coming from the outermost-phase chamber combined with the emulsion substance to form the multiple-emulsion substance, which is then discharged through a tube.

Description

Equipment for preparing cosmetic composition containing multiple emulsified substances formed by instant emulsification using microfluidic channels

The present disclosure relates to a device for preparing a cosmetic composition that distributes multiple emulsified substances formed by instantaneous emulsification when the external phase fluid and the dispersed phase fluid flow through the microfluidic channel. In particular, the present disclosure relates to a device for preparing a cosmetic composition containing multiple emulsified substances, the multiple emulsified substances are instantaneously emulsified so that the fluid flowing through the microfluidic channel meets the outermost fluid, and the most The outer phase fluid surrounds the fluid on the outside of the emulsified particles to express properties and is made by instant emulsification.

Generally speaking, fluid emulsification technology is used to disperse two immiscible fluids, such as one of water and oil, in small particles, and disperse it in the other fluid to form a stable state. In the cosmetics industry, emulsification technology is widely used in the manufacture of skin lotions, skin care creams, essences, massage creams, cleansing creams, makeup bases, foundation creams, eyeliner, mascara, etc. In other words, in order to make the cosmetics listed above, small particles of hydrophobic fluid such as oil are uniformly dispersed in a hydrophilic fluid such as water to produce O/W emulsified particles or oil-in-water emulsified particles, or small particles of hydrophilic fluid are uniformly dispersed in In the hydrophobic fluid, W/O emulsified particles or water-in-oil type emulsified particles are produced. The aforementioned O/W emulsified particles and W/O emulsified particles are called emulsions or emulsified substances.

In order to produce such emulsified substances, physical methods have typically been used to produce emulsified substances by using hydrophilic fluids and hydrophobic fluids. For example, as disclosed in Korean Patent No. 10-0222000, the conventional method is to place both a hydrophilic fluid and a hydrophobic fluid in a large chamber, and then use a mixer to combine particles of a fluid Disperse in another fluid. For example, the mixer used in this project can be a homogenizer or a microfluidizer. In other words, O/W emulsified particles or W/O emulsified particles are prepared by placing hydrophilic fluid and hydrophobic fluid in a large chamber, and then using a mixer to mix the fluids. The foregoing process is called a single emulsification.

In the foregoing process, a surfactant is further added to the mixture to reduce the interfacial energy between the hydrophilic fluid and the hydrophobic fluid, so as to easily form an emulsion, for example, O/W emulsified particles or W/O emulsified particles. Keep the interface film even harder to prevent the emulsified particles from binding. In particular, although emulsions such as O/W emulsified particles or W/O emulsified particles are produced by using a mixer, the emulsified particles are only combined for a given period of time after the operation of the mixer is stopped. Therefore, hydrophilic fluids and hydrophobic fluids May be separated from each other again. In order to avoid this phenomenon, a surfactant is added to stabilize the small emulsified particles and maintain a stable emulsified state for a long time.

The emulsified particles formed through a single emulsification process are placed in a chamber containing a hydrophilic fluid and a hydrophobic fluid, so that the emulsified particles can be emulsified again after the first emulsification process.

For example, the preparation method of W/O/W emulsified particles can be prepared by injecting W/O emulsified particles produced by primary emulsification into a chamber containing a hydrophilic fluid and performing secondary mixing. That is, the W/O/W emulsified particles of multiple emulsified substances can be prepared by covering the outer side of the W/O emulsified particles with a hydrophilic fluid. In a similar process, the O/W/O multiple emulsified substance particles can be prepared by injecting the O/W emulsified particles produced by primary emulsification into a chamber containing a hydrophobic fluid and performing secondary mixing. That is, the O/W/O emulsified particles of multiple emulsified substances (or multiple emulsions) can be prepared by covering the outer side of the O/W emulsified particles with a hydrophobic fluid.

This multiple emulsified substance is a material with a structure in which one emulsified substance is dispersed in the other emulsified substance, and the dispersed particles are smaller than the emulsified particles produced in a single emulsification process. The multiple emulsified substance described above has the advantages of the double effect of the wettability of W/O emulsified particles and the refreshing feeling of O/W emulsified particles. Depending on the type of emulsion, that is, W/O/W or O/W/O, the user can sequentially obtain the sensation provided by the outermost emulsion and the sensation provided by the innermost emulsified particles.

However, in the aforementioned prior art, after the W/O emulsified particles or O/W emulsified particles are manufactured, the manufactured emulsified particles are placed in a chamber containing a hydrophilic fluid and a hydrophobic fluid to prepare multiple emulsified substances. Therefore, the process is extremely complicated and the multiple emulsified substances produced are unstable. The reason is that the primary emulsification process does not include the thickening treatment used for the purpose of allowing the emulsified particles to be easily formed in the secondary emulsification process. It is extremely difficult to obtain long-term stable emulsions.

That is, for the manufacture of cosmetic compositions, it is required to prepare a large number of multiple emulsifying substances in advance to produce and sell the prepared cosmetic composition products to meet the needs of users. Therefore, it takes a long time from the production of multiple emulsified substances to the actual application as cosmetics.

Furthermore, considering the long-term stability issue of storing a large number of emulsion products for a long time, it is inevitable to impose many restrictions on the manufacturing, packaging and delivery process of multiple emulsified substances.

In summary, the present disclosure proposes a manufacturing device for a cosmetic composition containing multiple emulsified substances. When a user wants to use multiple emulsified substances, W The production process of /O/W emulsified particles or O/W/O emulsified particles can use this manufacturing equipment to prepare multiple emulsified substances.

According to one aspect of the present disclosure, there is provided a manufacturing equipment for a cosmetic composition containing multiple emulsified substances. The equipment includes: a housing equipped with a pump operated by a user; and a fluid container installed at In the casing, the fluid container has an outer phase chamber for storing the outer phase and outer phase fluid of the emulsified substance, and a dispersed phase chamber, which is used to store the dispersed phase fluid of the dispersed phase forming the emulsified substance. The outermost phase chamber, which is provided in the shell, and is used to store the outermost phase fluid that forms multiple emulsified materials by contacting the emulsified material; the first channel is used to make the outer phase fluid merge the Disperse phase fluid to form the emulsified substance; a second channel, which is provided with a space communicating with the first channel to form a passage for the emulsified substance to flow, and the second channel is adapted to allow the emulsified substance to flow from the outermost phase cavity The outermost phase fluid of the chamber combines the emulsified substance to form the multiple emulsified substance; and a pipe for discharging the multiple emulsified substance flowing through the second channel.

In a specific example of the device, the first channel and the second channel have the same corresponding structure.

In a specific example of the device, the first channel includes: an external phase fluid inlet into which the external phase fluid is injected; a dispersed phase fluid inlet into which the dispersed phase fluid is injected; and a first emulsified substance passage, which is the self The passage from the first channel to the second channel, and the emulsified substance is formed by the external phase fluid and the dispersed phase fluid meeting each other to merge.

In a specific example of the device, the second passage includes: a second emulsified substance passage, which is in communication with the first emulsified substance passage and allows the emulsified substance to flow into the second passage; from the outermost phase chamber The outermost phase fluid inlet into which the outermost phase fluid is injected; and the multiple emulsified substance outlet, which allows multiple emulsified substances formed by the emulsified substance contacting the outermost fluid to flow into the tube.

In a specific example of the device, the second emulsified substance passage is the component corresponding to the dispersed phase fluid inlet of the first channel.

In another specific example of the device, the first channel includes a first branch pipe and a second branch pipe, which are arranged to surround the dispersed phase fluid inlet into which the dispersed phase fluid flows, so that the outer phase fluid and the dispersed phase fluid The fluids meet in the form of the outer phase fluid surrounding the dispersed phase fluid; the outer phase fluid and the dispersed phase fluid meet at the intersection of the first branch pipe and the second branch pipe; the second channel includes a plurality of branch pipes and surrounds the The second emulsified substance passage into which the emulsified substance flows, so that the outermost phase fluid and the emulsified substance meet in a form in which the outermost phase fluid surrounds the emulsified substance; and the outermost phase fluid and the emulsified substance meet in the The intersection of the multiple emulsified substances where a plurality of branch pipes meet.

In another specific example of the device, the first channel includes an emulsifying component communicating with the intersection and emulsifying the external phase fluid and the dispersed phase fluid to form the emulsified substance. In addition, the second channel further includes an emulsifying component communicating with the intersection of the multiple emulsified substances and emulsifying the emulsified substance and the outermost phase fluid to form the multiple emulsified substances.

In another embodiment of the device, the emulsifying part of the first channel is an orifice having a width smaller than the intersection; and the emulsifying part of the second channel is an orifice having a width smaller than the intersection of the multiple emulsified substances.

In another embodiment of the device, at least a part of the second channel is formed to have hydrophilicity corresponding to the hydrophilicity of the outermost phase fluid.

In another embodiment of the device, at least part of the first channel is formed to have hydrophilicity corresponding to the hydrophilicity of the external phase fluid.

In yet another specific example of the device, the first channel and the second channel are arranged in a layered structure with each other.

Therefore, according to the present disclosure, when the user wants to use multiple emulsified substances, it is possible to prepare and distribute multiple emulsified substances to discharge the multiple emulsified substances while the user operates the pump for preparation.

Accordingly, since there is no need to store a large amount of multiple emulsified substances for a long time, the many restrictions imposed on the storage and transportation of the multiple emulsified substance products in consideration of the long-term stability of the product are no longer applicable to the present disclosure.

Furthermore, the present disclosure makes it easy to use the fluid performance properties when the fluid flows through the microfluidic channel when the user wants to use multiple emulsified substances, and through instant emulsification, from the storage state of the water phase raw material and the oil phase raw material. The formation of multiple emulsified substances.

According to the present disclosure, when a user wants to use multiple emulsified substances, the user may form and distribute multiple emulsified substances through instant emulsification, so the preparation method is extremely simple and the prepared multiple emulsified substances can maintain amines.

1‧‧‧Equipment

10‧‧‧Shell

20‧‧‧Fluid Container

21‧‧‧External phase chamber

22‧‧‧Disperse phase chamber

23‧‧‧Partition wall

30‧‧‧External phase fluid injection pipe

40‧‧‧Disperse phase fluid injection pipe

45‧‧‧The outermost chamber

46‧‧‧The outermost phase fluid injection pipe

50‧‧‧The first channel

51‧‧‧External phase fluid inlet

52‧‧‧The first pipe

53‧‧‧Second branch

54‧‧‧Disperse phase fluid inlet

55‧‧‧Disperse phase fluid delivery pipe

56‧‧‧Intersection

57‧‧‧Emulsified substance delivery pipe

58‧‧‧Orifice, emulsification parts

59‧‧‧The first emulsifying substance pathway

60‧‧‧tube

70‧‧‧Pump

80‧‧‧Second channel

81‧‧‧The outermost phase fluid inlet

82‧‧‧Branch

83‧‧‧Branch

84‧‧‧Second emulsifying substance pathway

85‧‧‧Emulsion material tube

86‧‧‧Intersection point of multiple emulsified substances

87‧‧‧Multiple emulsified substance delivery pipe

87a‧‧‧Orifice, emulsified parts

88‧‧‧Export of multiple emulsified substances

100‧‧‧Microfluidic channel

Figure 1 is a perspective view of an apparatus for preparing a cosmetic composition containing multiple emulsified substances according to an embodiment of the present disclosure.

Figure 2 is a top view showing the configuration of the first channel of the microfluidic channel in the device shown in Figure 1.

Figures 3A and 3B are cross-sectional views respectively showing O/W emulsified particles or W/O emulsified particles formed through the first channel.

Figure 4 is a top view showing the configuration of the second channel located on the first channel in the microfluidic channel of the device.

Figures 5A and 5B are cross-sectional views showing the emulsified substance of W/O/W emulsified particles or O/W/O emulsified particles formed through the second channel.

Figure 6 shows an exemplary experiment of W/O/W emulsified particles formed through microfluidic channels.

(Best mode)

Now, preferred specific examples of the present disclosure will be described with reference to the accompanying drawings. Although the present disclosure is described with reference to the specific examples depicted in the drawings, it should be noted that the description is only a specific example, and the technical ideas, key components, and functions of the present disclosure are not limited thereto.

Figure 1 is a perspective view of an equipment for preparing a cosmetic composition containing multiple emulsified substances according to a specific example of the present disclosure. Figure 2 is a top view showing the configuration of the first channel of the fluid channel in the device shown in Figure 1; and Figures 3A and 3B respectively show O/W emulsified particles made through the first channel Or a cross-sectional view of the emulsified substance of W/O emulsified particles.

With reference to the drawings, the appearance of the device 1 for preparing the cosmetic composition according to the present disclosure is formed with a housing 10. The pump 70 operated by the user is arranged on one side of the casing 10, and the user can press the pump 70 to discharge the material in the casing 10. For example, when the user presses the pump 70, the pressure supplied to the material flow path in the housing 10 increases. In this case, when the user releases his hand from the pump 70 to release the pressure, negative pressure in the material conveying path is caused to discharge the material.

The pump 70 is an energy-providing member. The energy provided by the pump 70 is used to discharge and instantaneously emulsify the fluid in the chambers 21, 22 and 45, and distribute the emulsified fluid mixture through an outlet formed on the outside of the housing 10. An operating unit located on one side of the housing 10 and operated by a user may be exposed outside the housing 10, and a connection unit for discharging the fluid mixture may be provided inside the housing 10. The pressure formed by the pump 70 causes the raw materials stored in the outer phase chamber 21, the dispersed phase chamber 22, and the outermost phase chamber 45 to be supplied to the microfluidic channel 100, and also causes the raw material supplied to the microfluidic channel 100 to flow After passing through the designated path, and then, after instant emulsification, it flows into the interior of the pump 70 through the tube 60. In order to achieve this, a fluid channel communicating with each other from the pump 70 to the individual chambers 21, 22, and 45 can be formed.

In this specific example, although the configuration of the pump 70 is described as having an outlet for discharging cosmetic materials exposed outside the housing 10, it should be noted that this is only an example, and the concept of the present disclosure is not limited by this. . For example, the outlet may be a separate unit from the pump 70, and the pump 70 may be connected to any point in the fluid channel connected from the chambers 21, 22, and 45 to the outlet to generate pressure.

The pump 70 described in this specific example is an exemplary pressing down of the pump, which is when the user presses the pump 70 and then releases the hand from its pump operation unit to release the pressure, the fluid inside the housing 10 The flow path generates negative pressure. In this example, the advantage of this configuration is that only the pressure generated in one direction formed by the pump 70 can make the raw materials discharged from the chambers 21, 22, and 45 flow through the microfluidic channel 100 and discharge The granular material contributes to the simple configuration of the equipment.

However, it should be noted that the concept of the present disclosure is not limited to this configuration, and any pump configured in a different manner from the pump 70 can be used. For example, the pump 70 can be a manually operated pump, such as a button spring pump, a syringe pump, a tube pump or a hose pump, a gear pump, a porous pump, or a threaded implant pump Or a pump that uses capillary action to suck or discharge fluid by applying an orifice, a ball, or a pencil to its outlet. Otherwise, motorized pumps can be used to control electricity, vibration, sound waves, or piezoelectric materials to suck or discharge fluids.

The housing 10 is provided with an external phase chamber 21 for storing the external phase fluid and a dispersed phase chamber 22 for storing the dispersed phase fluid. The external phase may be any of the oil phase and the water phase, and the dispersed phase may be any of the oil phase, the water phase, and the gas phase. For example, the external phase chamber 21 and the dispersed phase chamber 22 can be provided inside the housing 10 to form a fluid container 20. Specifically, the partition wall 23 extending from the top to the bottom and dividing the internal space of the fluid container 20 is installed in the center of the fluid container 20. The external phase flow system is stored on one side of the partition wall 23 to form the external phase chamber 21, and the dispersed phase flow system is stored on the other side thereof to form the dispersed phase chamber 22.

Furthermore, the outermost phase chamber 45 is disposed in the housing 10 to store the outermost phase fluid, which contacts the emulsified substance formed by the interaction of the dispersed phase fluid and the outer phase fluid to form multiple emulsified substances. For example, the outermost phase chamber 45 may be installed in the housing 10 with the fluid container 20 separated. As an example, the outermost phase fluid may have a similar range or substantially the same range of hydrophilicity as the dispersed phase fluid. For example, the outermost phase fluid and the dispersed phase fluid can have mutually compatible hydrophilicity, so that when the outermost phase fluid contacts the emulsified substance to form a multiple emulsified substance, the multiple emulsified substance can have the wettability of W/O emulsified particles and The double effect of refreshing feeling produced by O/W emulsified particles. That is, when the dispersed phase flow system is in the oil phase, the outermost phase fluid can also be in the oil phase; and when the dispersed phase flow system is in the water phase, the outermost phase fluid can also be in the water phase. But it should be noted that the concept disclosed in this article is not limited by this, and if necessary, the dispersed phase fluid and the outermost phase fluid can be in various combinations.

The external phase chamber 21 and the dispersed phase chamber 22 are connected to the external phase fluid injection pipe 30 and the dispersed phase fluid injection pipe 40, and the latter two are respectively used as paths for the external phase fluid and the dispersed phase fluid stored therein to flow. In other words, the external phase fluid stored in the external phase chamber 21 can be discharged from the external phase chamber 21 through the external phase fluid injection pipe 30. In a similar manner, the dispersed phase fluid stored in the dispersed phase chamber 22 can be discharged from the dispersed phase chamber 22 through the dispersed phase fluid injection pipe 40.

Furthermore, the outermost phase chamber 45 is connected to the outermost phase fluid injection pipe 46, which is a path for allowing the outermost phase fluid stored therein to flow. That is, the outermost phase fluid stored in the outermost phase chamber 45 can be discharged from the outermost phase chamber 45 through the outermost phase fluid injection pipe 46. As described above, the outermost phase fluid may be in any of the oil phase and the water phase.

As for the configuration, the connections of the individual chambers 21, 22, and 45 to the injection pipes 30, 40, and 46, respectively, can be equipped with switches, such as valves, to control the opening and closing of the connection, so that only when pressure is applied to the connection , The contents are discharged toward the injection pipes 30, 40, and 46.

In the present disclosure, the equipment for preparing cosmetic compositions does not use a conventional syringe pump that uses positive pressure, but instead uses a microfluidic channel 100 that only uses negative pressure. That is, because the present disclosure only uses negative pressure on the microfluidic channel 100 to discharge the emulsified substance, it has an advantage: the device according to the present disclosure can be directly applied to the conventional cosmetic container and pump structure.

Conventionally, due to the large interfacial tension between the external phase fluid and the dispersed phase fluid, the fluids are difficult to mix, and an excess of 1% to 5% of surfactant is required to form emulsified particles and maintain stability of the emulsified particles. However, in a certain infinitely small length or a length not greater than one millimeter, the surface force acting on the fluid in the microfluidic channel 100 is even greater than the body force. In this way, it is excellent that no surfactant is used, or the amount of surfactant added to achieve rapid emulsification is minimized. Furthermore, between two immiscible fluids, the principle that one fluid interrupts the flow of the other fluid to form emulsified particles helps reduce the amount of surfactant required.

Although the emulsification method using the microfluidic channel 100 has the aforementioned multiple advantages, its manufacturing speed is slower than that of a conventional emulsifier using a large tank and a mixer, so this emulsification method is not an ideal option for applying to cosmetic manufacturing equipment. In order to solve this manufacturing speed problem, the present disclosure develops the first channel 50 that can be applied to the container, and adopts an instant emulsification method that emulsifies based on a predetermined amount of emulsified substance that is dispensed when the user wants to use the emulsified substance .

One end of the external phase fluid injection tube 30 and one end of the dispersed phase fluid injection tube 40 are connected to the first channel 50 of the microfluidic channel 100. The microfluidic channel 100 can be formed at the bottom of the housing 10 as a passage for fluid to flow. Furthermore, the microfluidic channel 100 may include a first channel 50 assembled at the bottom thereof, and a second channel 80 located on the top of the first channel 50. However, depending on the specific example, the first channel 50 may be located on top of the second channel 80, and it may be provided in a non-layered structure. As in this embodiment, when the first channel 50 and the second channel 80 are formed in a layered structure, the space in the housing 10 can be effectively used, and the overall size of the device can be reduced.

First, the first channel 50 may be formed with an inlet communicating with the external phase fluid injection pipe 30 and the dispersed phase fluid injection pipe 40. In other words, the first channel 50 includes an outer phase fluid inlet 51 as a passage through which the outer phase fluid flows through the outer phase fluid injection pipe 30 and a dispersed phase fluid inlet 54 as a passage through which the dispersed phase fluid flows through the dispersed phase fluid injection pipe 40.

The outer phase fluid entering the first channel 50 through the outer phase fluid inlet 51 can flow downstream toward the pump 70, and the inlet 51 is divided into a first branch pipe 52 and a second branch pipe 53. As used herein, the term “downstream” refers to the direction in which the fluid stored in the fluid container 20 is discharged from the pump 70 through the first channel 50 and the tube 60 when the pump is operated by the user.

Similarly, the dispersed phase fluid entering the first channel 50 through the dispersed phase fluid inlet 54 can flow downstream through the dispersed phase fluid delivery pipe 55. The external phase fluid flowing through the first branch pipe 52 and the second branch pipe 53 meets the dispersed phase fluid flowing through the dispersed phase fluid delivery pipe 55 at the intersection point 56. That is, the intersection point 56 is the first point where the outer phase fluid and the dispersed phase fluid meet in the housing 10.

The outer phase fluid and the dispersed phase fluid that meet at the intersection 56 pass through the emulsifying member 58 and become emulsions, that is, emulsified substances. The exemplary emulsifying member 58 provided and described in this specific example is an orifice 58 whose width is narrower than that of the intersection 56. As shown in FIG. The outer phase fluid and the dispersed phase fluid that meet at the intersection 56 pass through the orifice 58, and the force in the narrower or vertical direction of the orifice 58 (ie, the diagonal direction toward the center of the orifice 58) is the same as the force in the fluid flow The combination direction of the force in the direction or the horizontal direction. The outer phase fluid exerts a shear force on the dispersed phase fluid to interrupt the dispersed phase fluid to generate emulsified substances. The direction of the combined forces is the diagonal direction toward the center of the orifice 58. In particular, when two immiscible fluids pass through the orifice 58 and the interface is unstable, the capillary instability is increased. Compared with the channel without the orifice 58, the channel with the orifice 58 can even have less energy. Interrupt the flow of the dispersed phase fluid. The dispersed phase fluid whose flow is interrupted is formed into a sphere to maintain stability.

The emulsification part 58 is used to enable the external phase fluid to interrupt the flow of the fluid mixture and disperse the fluid mixture into particles in the external phase fluid. Although the exemplary emulsification part 58 provided and described in this embodiment is an orifice, it must Note that the concept of this disclosure is not limited by this. In particular, the emulsification method using orifices is used in this specific example, which is called flow focusing emulsification. The implementation is by allowing fluids of different phases to flow in the same direction, but setting orifices at the intersections so that the outer phase fluid The dispersed phase fluid can be interrupted. The orifice used as described above can divert the flow of the external phase fluid in a diagonal direction in the orifice, and cause a greater shear force on the fluid mixture, thereby making it easier to make emulsified particles and at the same time form particles of similar size. Emulsified particles.

Furthermore, as for the emulsification component 58, various specific examples can be applied as follows, and applicable examples include: a method for emulsifying fluids of different phases while making them flow in the same direction, that is, a co-stream method; A method of emulsifying fluids of different phases and making them flow in a staggered manner at the same time, that is, the staggered flow method; used to adjust the aspect ratio of the inlets of the external phase fluid and the dispersed phase fluid leading to the intersection point to be larger or smaller, so as to be at the intersection point The method for generating emulsified particles, that is, the stepwise emulsification method; and the method for forming the emulsified particles by letting the dispersed phase fluid or the mixture of two different phases of fluid flow through the pores of the membrane, that is, the film emulsification method.

A power source can be used as the emulsification component 58, and an exemplary applicable channel for forming emulsified particles can be controlled by using electric field or electric power control, magnetic field or magnetic force control, centrifugal force or centrifugal control, laser or optical control, vibrator or vibration control , Piezoelectric materials or piezoelectric control to achieve.

The emulsification component 58 can generate emulsified particles by changing the fluid viscosity, interfacial tension, and moisture level, and exemplary applications include electrorheological fluid or ER fluid, magnetorheological fluid or MR fluid, or photosensitive fluid.

The emulsified substance formed when flowing through the orifice 58 flows through the emulsified substance delivery pipe 57. As used herein, the term "upstream" refers to the opposite direction of "downstream", which means the reverse of the direction of fluid flow when the user's pumping operation is used, that is, toward the pump 70, the tube 60, and the microfluidic channel 100, and the direction of the fluid container 20.

In the prior art, the size of the emulsified substance has been controlled by controlling the amount of surfactant added to the emulsified substance. However, according to the disclosure, the size of the emulsified substance can be controlled only by controlling the width of the orifice 58. However, the width of the orifice 58 has a predetermined minimum value, and thus the size of the emulsified substance has a lower limit.

In particular, in cosmetics manufactured by using emulsifiers, the size and content of emulsified particles are important factors that determine the quality of cosmetics. Generally speaking, the ratio of the injected external phase fluid must be equal to or higher than the injected ratio of the dispersed phase fluid to generate emulsified particles. For example, the amount of the external phase fluid injected can be equal to the amount of the dispersed phase fluid injected up to 30 times the latter.

As disclosed herein, in the microfluidic channel 100 that only uses negative pressure, the flow rate of the fluid is determined by the structural elements of the fluid channel 100 and the fluid flow conditions, so the size and content of the emulsified particles vary. Exemplary structural elements of the fluid channel 100 include channel height, orifice width, and the ratio of the width of individual channels for injecting fluid. Examples of fluid flow conditions include negative pressure strength, flow ratio of two fluids, and viscosity ratio of two fluids.

When the channel height is low; the orifice width is narrow; the negative pressure strength is high; the flow ratio of the outer phase fluid to the dispersed phase fluid is larger; and when the viscosity of the dispersed phase fluid is greater than the viscosity of the outer phase fluid, the emulsified particles become smaller , But becomes larger under the opposite conditions.

In the present disclosure, the method for controlling the inner diameter of the respective inlets of the dispersed phase fluid and the outer phase fluid is used to control the flow ratio of the dispersed phase fluid and the outer phase fluid. In particular, when the inner diameter of the outer phase fluid inlet is twice as large as the inner diameter of the dispersed phase fluid inlet, only under negative pressure, the volume of the outer phase fluid flow is double that of the dispersed phase fluid flow. In the same way, the ratio of the dispersed phase fluid flow to the outer phase fluid flow can be controlled.

Furthermore, in the aforementioned method for preparing multiple emulsified substances, by controlling the ratio of the three types of injected fluid streams, two effects are expected to be obtained. The first effect is that the film thickness of the multiple emulsified substances produced after the second emulsification can be controlled by controlling the same ratio of the dispersed phase fluid flow to the outer phase fluid flow as in the first emulsification. The second effect is that in the second emulsification, by controlling the injection ratio of the dispersed phase fluid flow and the external phase fluid flow, it is possible to control the multiple emulsified substances after the first emulsification and inject them into the second channel as the dispersed phase. Seal the number of emulsified particles.

The emulsified substance flowing through the intersection 56 and the orifice 58 flows through the emulsified substance delivery pipe 57. The end of the emulsified substance delivery pipe 57 is formed with a first emulsified substance passage 59 that communicates with the second passage 80 and serves as a passage for the emulsified substance to discharge from the first passage 50. Furthermore, the second passage 80 is formed with a second emulsified substance passage 84 communicating with the first emulsified substance passage 59 and used as a passage for the emulsified substance to flow into the second passage 80.

The configuration of the second channel 80 communicating with the first channel 50 is as follows.

Figure 4 is a top view showing the configuration of the second channel on top of the first channel in the fluid channel of the device. Figures 5A and 5B are cross-sectional views of emulsified substances, which respectively show W/O/W emulsified particles or O/W/O emulsified particles formed through the second channel.

Referring to the drawings, the first passage 50 and the second passage 80 may have the same structure. That is, the first passage 50 and the second passage 80 are arranged in different directions, but the entire structure is the same. For example, the second channel 80 can be arranged on the top of the first channel 50 but rotated 180 degrees relative to the first channel 50. The second emulsified substance passage 84 of the second channel 80 communicating with the first emulsified substance passage 59 of the first channel 50 may be a part corresponding to the dispersed phase fluid inlet 54 of the first channel 50. That is, the emulsified substance that enters the second channel 80 through the second emulsified substance passage 84 constitutes a dispersed phase of multiple emulsified substances.

As shown in the figure, the emulsified substance that enters the second channel 80 through the second emulsified substance passage 84 passes through the emulsified substance pipe 85 and flows into the multiple emulsified substance intersection 86.

The second passage 80 is formed with a path through which the outermost phase fluid from the outermost phase fluid injection pipe 46 flows. Specifically, the outermost phase fluid stored in the outermost phase chamber 45 in the housing 10 flows into the outermost phase fluid inlet 81 of the second channel 80 through the outermost phase fluid injection pipe 46 by means of negative pressure. The outermost phase fluid inlet 81 of the second channel 80 corresponds to the portion of the dispersed phase fluid inlet 54 of the first channel 50. The outermost phase fluid entering the second channel 80 through the outermost phase fluid inlet 81 passes through the branch pipes 82 and 83 to flow into the multiple emulsified substance intersection 86.

The intersection 86 of the multiple emulsified substances corresponds to the intersection 56 of the first channel 50 and is the point where the emulsified substances meet the outermost fluid.

The emulsified substance and the outermost phase fluid that meet at the intersection 86 of the multiple emulsified substances are emulsified when passing through the emulsifying member 87a. The exemplary emulsification member 87a provided and described in this specific example is an orifice with a width narrower than the intersection 86 of the multiple emulsification substances. When the emulsified substance and the outermost phase fluid that meet at the intersection 86 of the multiple emulsified substances pass through the orifice 87a with a relatively narrow width and meet each other, the force in the narrower direction or the vertical direction of the orifice 58 is the same as the fluid flow Directional or horizontal force. In the direction where the forces are combined, the outermost fluid exerts a shear force on the emulsified material, interrupting the flow of the emulsified material to generate multiple emulsified materials. The direction of combining these forces is the pair toward the center of the orifice 87a. Angular direction. In particular, when two immiscible fluids pass through the orifice 87a and the interface is unstable, the capillary instability is increased. Compared with the channel without the orifice 87a, the channel with the orifice 87a can be even smaller. Energy interrupts the flow of emulsified material. The emulsified substance whose flow is interrupted is formed into a sphere to maintain stability. The material formed as described above is called a multiple emulsion, that is, a multiple emulsified substance.

The multiple emulsified substance formed when passing through the orifice 87 a flows through the multiple emulsified substance delivery pipe 87. The multiple emulsified substance flowing through the multiple emulsified substance conveying pipe 87 flows into the multiple emulsified substance outlet 88 formed at the end of the multiple emulsified substance conveying pipe 87. The multiple emulsified substance outlet 88 communicates with the pipe 60 and serves as a passage for the multiple emulsified substance to discharge from the second passage 80.

At the same time, the tube 60 may be made of a transparent material to allow the user to visually inspect the emulsified substance flowing through 60 from the outside. In order to achieve this, it is also necessary to use materials to create the area around the tube 60 of the shell 10 to allow the user to visually inspect the emulsified substance flowing through the tube 60 from the outside.

The pump 70 is installed at the end of the tube 60, and the user can dispense the emulsified substance from the outlet of the pump 70, which flows through the device 1 to prepare a cosmetic composition.

In this specific example, it is described that the second channel 80 is placed on top of the first channel 50, but it should be noted that the concept of the present disclosure is not limited by this. For example, the second channel 80 may be placed on the bottom side of the first channel 50. In this case, because the location of the first channel 50 is closer to the chambers 21 and 22, the external phase fluid and the dispersed phase fluid are first supplied to the first channel 50 and emulsified, and then supplied to the first channel located farther from the chambers. The configuration of the two-channel 80 can be further simplified. Furthermore, the first passage 50 and the second passage 80 can be formed on the same plane. In order to achieve this, the first emulsified substance passage 59 of the first passage 50 and the second emulsified substance passage 84 of the second passage 80 may be substantially the same. Another exemplary applicable configuration is that the first channel 50 is located in the inner space of the branch pipes 82 and 83 for allowing the outermost phase fluid to flow.

At the same time, although it is described that the second channel 80 has the same configuration as the first channel 50, it should be noted that the concept of the present disclosure is not limited by this. As described above, the second channel 80 can be a microfluidic channel in which two immiscible fluids of different phases meet each other using various methods, and one of them is a microfluidic channel in which particles are dispersed in the other fluid. For example, the first channel 50 may be a channel that uses an orifice as an emulsification member, and the second channel 80 may be the outermost phase fluid flowing in one direction, and the emulsification member is used to supply the first emulsified substance at a predetermined angle. aisle.

Depending on the outermost fluid of the oil phase or O, and the water phase or W, multiple emulsified substances can be formed by the aforementioned configuration.

First, when the outermost phase flow system is in the oil phase or O, the dispersed phase fluid can be either in the oil phase or O, the water phase or W, and the gas phase or G; and the outer phase fluid can be in the oil phase or O and Either the water phase or W. Accordingly, when the outermost phase flow system is in the oil phase or O, O/O/O, O/W/O, W/O/O, W/W/O, G/O/O, G/W can be formed /O and other emulsifying substances. Moreover, when the outermost phase flow system is in the water phase or W, the dispersed phase fluid can be in any of the oil phase or O, the water phase or W, and the gas phase or G; and the outer phase fluid can be in the oil phase or O and Either the water phase or W. Therefore, when the outermost phase flow system is in the water phase or W, it can be made into O/O/W, O/W/W, W/O/W, W/W/W, G/O/W, and G/ W/W emulsifying substance. In this case, when the dispersed phase fluid and the external phase fluid, or the external phase fluid and the outermost phase fluid are both in the oil phase or O, or water phase or W, it must be understood that the use of similar hydrophilicity but immiscible miscibility Fluid.

At the same time, the inner wall of the multiple emulsified substance delivery tube 87 of the second channel 80 can be arranged to have a hydrophilic property corresponding to the outermost phase fluid. In this case, since the outermost phase fluid belonging to the outer phase of the multiple emulsified substance is attracted to the inner wall of the multiple emulsified substance conveying pipe 87, and conversely, the first emulsified substance is far away from the inner wall of the multiple emulsified substance conveying pipe 87, so It can flow while maintaining a stable state where the outermost phase fluid forms the outer side of multiple emulsified substances. For example, when the outermost phase fluid is oil, the inner wall of the multiple emulsified substance delivery pipe 87 may be coated with a hydrophobic material or a hydrophobic film. When the outermost phase fluid is water, the inner wall can be coated with a hydrophilic material or a hydrophilic film. Depending on the specific example, other configurations of the second channel 80 and the multiple emulsified substance delivery tube 87 can be applied to have a hydrophilic property corresponding to the outermost phase fluid. That is, at least part of the second channel 80 may be formed to have a hydrophilic property corresponding to the hydrophilicity of the outermost phase fluid.

Furthermore, the inner wall of the emulsified substance delivery tube 57 of the first channel 50 can be provided to have hydrophilic properties corresponding to the outer phase fluid. In this case, because the outer phase fluid that forms the outer phase of the emulsified substance is attracted to the inner wall of the emulsified substance conveying pipe 57, on the contrary, the dispersed phase fluid is far away from the inner wall of the emulsified substance conveying pipe 57, so the emulsified substance can flow at the same time. Maintain the stability of the emulsified state. For example, when the outer phase fluid is oil, the inner wall of the emulsified substance delivery tube 57 can be coated with a hydrophobic material or a hydrophobic film, and when the outer phase fluid is water, the inner wall can be coated with a hydrophilic material or a hydrophilic film. Depending on the specific example, other configurations of the first channel 50 and the emulsified substance delivery tube 57 can be applied to have a hydrophilic property corresponding to the external phase fluid. That is, at least part of the first channel 50 can be manufactured to have a hydrophilic property corresponding to the hydrophilicity of the external phase fluid.

In this specific example, the hydrophilic material or the hydrophilic film may be a material with a water contact angle ranging from 0 degrees to 50 degrees, and the hydrophobic material or a hydrophobic film may be a material with a water contact angle ranging from 70 degrees to 120 degrees. .

When describing the formation of O/W/O emulsified particles and W/O/W emulsified particles, the following describes the fluid flow for an exemplary multiple emulsified substance.

First, the discharge procedure of O/W/O emulsified particles is described as follows.

In order to discharge O/W/O emulsified particles, the outer phase fluid may be a hydrophilic fluid like oil, and the dispersed phase fluid may be a hydrophobic fluid like water. The hydrophilic flow system is stored in the external phase chamber 21 and the hydrophobic flow system is stored in the dispersed phase chamber 22.

In this state, when the user presses down the pump 70 and then removes the hand from the pump 70, negative pressure is generated on the space for storing fluid and the fluid conveying path, and discharged from the chambers respectively Hydrophilic fluid and hydrophobic fluid.

Specifically, the hydrophilic fluid flows into the external phase fluid inlet 51 of the first channel 50 through the external phase fluid injection pipe 30. However, the hydrophobic fluid flows into the dispersed phase fluid inlet 54 of the first channel 50 through the dispersed phase fluid injection pipe 40. The hydrophilic fluid and the hydrophobic fluid entering the first channel 50 will be at the intersection 56 of the first channel 50 and pass through the orifice 58. In this process, the hydrophobic fluid is dispersed in the hydrophilic fluid in the form of small particles. That is, emulsification occurs, allowing the hydrophilic fluid to surround the hydrophobic fluid.

During this process, O/W (that is, oil-in-water type) emulsified particles are formed, in which the oil system is dispersed in water (refer to Figure 3A).

In order to achieve this, the first channel 50, especially the emulsified substance delivery tube 57, can be made of a hydrophilic material, or the inner wall of the fluid flowing through it can be coated with a hydrophilic material. In particular, because the emulsified substance has a configuration in which its inner wall is made of hydrophilic fluid and the hydrophobic fluid is dispersed therein, the hydrophilic fluid in the emulsified substance is attracted to the inner wall of the emulsified substance delivery tube 57, and Here, the emulsified substance delivery tube 57 is made of a hydrophilic material. Therefore, the O/W emulsified particles as described above can effectively flow through the emulsified substance delivery pipe 57 while maintaining the stability of its shape and structure.

In the foregoing process, the O/W emulsified particles flowing through the first emulsified substance passage 59 of the first channel 50 flow into the second channel 80 on the top of the first channel 50. Specifically, the O/W emulsified particles flow into the second channel 80 through the second emulsified material passage 81 of the second channel 80 communicating with the first emulsified material passage 59 of the first channel 50.

The second emulsified substance passage 84 is a component corresponding to the dispersed phase fluid inlet 54 of the first channel 50, and the O/W emulsified particles flowing through the second emulsified substance passage 84 form a dispersed phase of multiple emulsified substances. That is, the O/W emulsified particles entering the second channel 80 through the second emulsified substance passage 84 flow into the multiple emulsified substance intersection 86 through the emulsified substance pipe 85.

The outermost phase fluid flows from the outermost phase chamber 45 through the outermost phase fluid injection pipe 46 and flows into the outermost phase fluid inlet 81 formed in the second channel 80. That is, the outermost fluid forms an outer phase of multiple emulsified substances. Generally, the outermost phase fluid may be a hydrophobic fluid having a hydrophilicity in a similar range or substantially the same range as the dispersed phase fluid. That is, the outermost phase fluid can be a hydrophobic fluid, so the hydrophobic fluid covers the outer side of the O/W emulsified particles, so that the prepared multiple emulsified substance has both effects of W/O emulsified particles and O/W emulsified particles.

The outermost phase fluid entering the second channel 80 passes through the branch pipes 82 and 83 that allow the outermost phase fluid to flow in the second channel 80, and then flows into the intersection 86 of the multiple emulsified substances. Therefore, when the O/W emulsified particles contact the outermost phase fluid in the orifice 87a, the emulsified material and the outermost phase fluid flowing through the multiple emulsified material intersection 86 become O/W/O emulsified particles (refer to Fig. 5A).

The O/W/O emulsified particles manufactured in the foregoing process flow into the multiple emulsified substance outlet 88 through the multiple emulsified substance delivery pipe 87.

For example, the second channel 80 (especially the multiple emulsified substance delivery tube 87) can be made of a hydrophobic material, or its inner wall can be coated with a hydrophobic material. Specifically, because the outer side of the multiple emulsified substance is made of hydrophobic fluid, the hydrophobic fluid in the emulsified substance is attracted to the inner wall of the emulsified substance delivery pipe 87, where the multiple emulsified substance delivery pipe 87 is used Made of hydrophobic materials. Therefore, the aforementioned O/W/O emulsified particles can effectively flow through the multiple emulsified substance delivery pipe 87 while maintaining the stability of its shape and structure.

The O/W/O emulsified particles flowing through the multiple emulsified material outlet 88 can be discharged to the user through the outlet of the pump 70 above the tube 60.

In a similar process, refer to Figure 4 to describe the discharge process of W/O/W emulsified particles as follows.

In order to discharge W/O/W emulsified particles, the outer phase fluid may be a hydrophobic fluid like oil, and the dispersed phase fluid may be a hydrophilic fluid like water. The hydrophobic flow system is stored in the external phase chamber 21, and the hydrophilic flow system is stored in the dispersed phase chamber 22.

In this state, when the user presses the pump 70 downward, a negative pressure is generated in the space for storing the fluid and the path for the fluid to flow in the housing 10. Subsequently, when the user removes his hand from the pump 70, a negative pressure is generated on the material conveying path to discharge the hydrophobic fluid and the hydrophilic fluid from the cavity thereof, respectively.

Specifically, the hydrophobic fluid flows into the external phase fluid inlet 51 of the first channel 50 through the external phase fluid injection pipe 30. The hydrophilic fluid flows into the dispersed phase fluid inlet 54 of the first channel 50 through the dispersed phase fluid injection pipe 40. The hydrophobic fluid entering the first channel 50 flows into the intersection 56 through the first branch pipe 52 and the second branch 53 and the hydrophilic fluid flows into the intersection 56 through the dispersed phase fluid delivery pipe 55. That is, the hydrophobic fluid and the hydrophilic fluid meet each other at the intersection 56 of the first channel 50 and pass through the orifice 58. In this process, in the so-called emulsification process, the hydrophilic fluid is dispersed in the hydrophobic fluid in the form of small particles. That is, an emulsified substance in the form of a hydrophobic fluid surrounding a hydrophilic fluid is formed.

The emulsified substance passing through the orifice 58 flows through the emulsified substance delivery pipe 57. During this process, W/O or water-in-oil type emulsified particles are formed, in which the water system is dispersed in the oil (refer to Figure 3B).

For example, the first channel 50 (especially the emulsified substance delivery tube 57) may be made of a hydrophobic material, or its inner wall through which the fluid flows may be coated with a hydrophobic material. In particular, because the emulsified substance has a configuration in which its outer side is made of hydrophobic fluid and the hydrophilic fluid is dispersed therein, the hydrophobic fluid in the emulsified substance is attracted to the inner wall of the emulsified substance delivery tube 57, At this point, the emulsified substance delivery tube 57 is made of hydrophobic material. Therefore, the W/O emulsified particles as described above can effectively flow through the emulsified substance delivery pipe 57 while maintaining the stability of its shape and structure.

The W/O emulsified particles flowing through the first emulsified substance passage 59 of the first channel 50 flow into the second channel 80 on the top of the first channel 50. Specifically, the W/O emulsified particles flow into the second channel 80 through the second emulsified substance passage 84 of the second channel 80 communicating with the first emulsified substance passage 59 of the first channel 50.

The second emulsified substance passage 84 is a component corresponding to the dispersed phase fluid inlet 54 of the first channel 50, and the W/O emulsified particles flowing through the second emulsified substance passage 84 form a dispersed phase of multiple emulsified substances. That is, the W/O emulsified particles entering the second channel 80 through the second emulsified substance passage 84 flow into the multiple emulsified substance intersection 86 through the emulsified substance pipe 85.

The outermost phase fluid flows from the outermost phase chamber 45 through the outermost phase fluid injection pipe 46 and flows into the outermost phase fluid inlet 81 formed in the second channel 80. That is, the outermost fluid constitutes the outer phase of multiple emulsified substances. Generally, the outermost phase fluid may be a hydrophilic fluid having a hydrophilicity in a similar range or substantially the same range as that of the dispersed phase fluid. That is, the outermost phase fluid can be a hydrophilic fluid, so the hydrophilic fluid covers the outer side of the W/O emulsified particles so that the prepared multiple emulsified material has the wetting of the W/O emulsified particles and the refreshing of the O/W emulsified particles Sense of two effects.

The outermost phase fluid entering the second channel 80 flows through the branch pipes 82 and 83 through which the outermost phase fluid flows in the second channel 80, and then flows into the multiple emulsified material intersection 86. Therefore, when the W/O emulsified particles contact the outermost phase fluid in the orifice 87a, the emulsified material and the outermost phase fluid flowing through the multiple emulsified material intersection 86 become W/O/W emulsified particles (refer to Figure 5B).

The W/O/W emulsified particles manufactured in the foregoing process flow into the multiple emulsified substance outlet 88 through the multiple emulsified substance delivery pipe 87.

For example, the second channel 80 (especially the multiple emulsified substance delivery tube 87) can be made of a hydrophilic material, or its inner wall can be coated with a hydrophilic material. In particular, because the outer side of the multiple emulsified substance is made of hydrophilic fluid, the hydrophilic fluid in the emulsified substance is attracted to the inner wall of the emulsified substance delivery pipe 87, where the multiple emulsified substance delivery pipe 87 is Made of hydrophilic materials. Therefore, the aforementioned W/O/W emulsified particles can effectively flow through the multiple emulsified substance delivery pipe 87 while maintaining the stability of its shape and structure.

The W/O/W emulsified particles flowing through the multiple emulsified material outlet 88 can be discharged to the user through the outlet of the pump 70 above the tube 60.

Figure 6 shows exemplary W/O/W emulsified particles prepared in the foregoing process. Specifically, Figure 6 illustrates an exemplary experiment for W/O/W emulsified particles.

As described above, when the user's pumping operation is used to generate multiple emulsified substances, the formed multiple emulsified substances are distributed according to the present disclosure, so it may be prepared and distributed when the user wants to use multiple emulsified substances .

Furthermore, since the multiple emulsified substances are made and supplied by instant emulsification according to the present disclosure when the user wants to use them, the manufacturing method is extremely simple and the made multiple emulsified substances can remain stable.

It should be noted that the above-mentioned explanation only illustrates the technical concept of this disclosure, and within the scope that does not deviate from the basic characteristics of this disclosure, those skilled in this disclosure can modify and change the concept of this disclosure in various ways. Therefore, the embodiments disclosed in the present disclosure are not intended to be limited by this, but are intended to explain the technical concept of the present disclosure, and the scope of the technical concept of the present disclosure is not limited by the embodiments. It should be noted that the scope of protection disclosed in this article must be inferred from the scope of the following patent applications, and all technical ideas within its equivalent scope must be understood as falling within the scope of rights disclosed in this article.

(Industrial applicability)

The present disclosure relates to equipment for preparing a cosmetic composition containing multiple emulsified substances made based on microfluidic channels in instant emulsification, and can be applied to the cosmetics industry.

1‧‧‧Equipment

10‧‧‧Shell

20‧‧‧Fluid Container

21‧‧‧External phase chamber

22‧‧‧Disperse phase chamber

23‧‧‧Partition wall

30‧‧‧External phase fluid injection pipe

40‧‧‧Disperse phase fluid injection pipe

46‧‧‧The outermost phase fluid injection pipe

60‧‧‧tube

70‧‧‧Pump

100‧‧‧Microfluidic channel

Claims (10)

A device for preparing a granular composition containing multiple emulsified substances. The device includes: a casing installed with a pump operated by a user; a fluid container installed in the casing, and the fluid The container has an outer phase chamber for storing the outer phase and outer phase fluid of the emulsified substance, and a dispersed phase chamber for storing the dispersed phase fluid of the dispersed phase of the emulsified substance; the outermost phase chamber is arranged in the shell In the body, it is used to store the outermost phase fluid that generates multiple emulsified substances by contacting the emulsified substance; the first channel is used to make the outer phase fluid merge with the dispersed phase fluid to form the emulsified substance; the second channel, It is provided with a space communicating with the first channel for forming a passage for the emulsified substance to flow, and the second channel is adapted to make the outermost phase fluid from the outermost phase chamber merge with the emulsified substance to form the emulsified substance Multiple emulsified substances; a tube for discharging the multiple emulsified substances flowing through the second channel; and wherein, the first channel and the second channel are arranged in a layered structure with each other. In the device described in item 1 of the scope of patent application, the first channel and the second channel have the same corresponding structure. The device described in item 2 of the scope of patent application, wherein the first channel package Including: the external phase fluid inlet into which the external phase fluid is injected; the dispersed phase fluid inlet into which the dispersed phase fluid is injected; and a first emulsified substance passage, which is a passage for the emulsified substance to flow from the first passage to the second passage, The emulsified substance is formed when the external phase fluid and the dispersed phase fluid meet each other and merge. The device described in item 3 of the scope of patent application, wherein the second passage includes: a second emulsified substance passage communicating with the first emulsified substance passage and allowing the emulsified substance to flow into the second passage; from the outermost phase The outermost phase fluid inlet into which the outermost phase fluid of the chamber is injected; and the multiple emulsified material outlet that allows the multiple emulsified material formed by the emulsified material contacting the outermost fluid to flow into the tube. The device described in item 4 of the scope of patent application, wherein the second emulsified substance passage is a component corresponding to the dispersed phase fluid inlet of the first passage. The device described in claim 1, wherein the first channel includes a first branch pipe and a second branch pipe, and the first branch pipe and the second branch pipe are arranged to surround the dispersed phase fluid into which the dispersed phase fluid flows Inlet so that the external phase fluid and the dispersed phase fluid meet in the form that the external phase fluid surrounds the dispersed phase fluid; the external phase fluid and the dispersed phase fluid meet in the first branch pipe and The intersection of the second branch pipe; the second channel includes a plurality of branch pipes and surrounds the second emulsified substance passage into which the emulsified substance flows, so that the outermost phase fluid and the emulsified substance surround the emulsification with the outermost phase fluid The material forms meet; and the outermost phase fluid and the emulsified material meet at the intersection of the multiple emulsified materials where the plurality of branch pipes meet. The device according to item 6 of the scope of patent application, wherein the first channel further comprises an emulsifying member communicating with the intersection and emulsifying the external phase fluid and the dispersed phase fluid to form the emulsified substance; and the second channel further It comprises an emulsifying component communicating with the intersection of the multiple emulsified substance and emulsifying the emulsified substance and the outermost phase fluid to form the multiple emulsified substance. The device described in item 7 of the scope of patent application, wherein the emulsifying part of the first channel is an orifice having a width smaller than the intersection point; and the emulsifying part of the second channel is a width smaller than the intersection point of the multiple emulsified substances Orifice. The device described in item 7 of the scope of patent application, wherein at least a part of the second channel is formed to have a hydrophilicity corresponding to the hydrophilicity of the outermost phase fluid. The device described in item 7 of the scope of patent application, wherein at least part of the first channel is formed to have a hydrophilicity corresponding to the hydrophilicity of the external phase fluid.

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