TWI480039B - Aqueous composition for contact lens - Google Patents

Description

Liquid composition for contact lenses

This invention relates to a liquid composition for contact lenses.

With the popularization and development of human civilization and education, more and more people suffer from myopia. The contact lens usage rate is very high considering convenience and habit. Use of contact lenses must be cleaned and maintained, otherwise eyeballs may be injured by microbes or contaminants on the contact lenses.

The usual method of maintaining contact lenses is to clean the lens with a contact lens cleaning solution containing a surfactant. After the cleaning step, the contact lens is typically immersed in a solution to remove residue from the lens. In addition, maintenance methods include sterilizing the lens to remove possible microorganisms from the lens. Conventional contact lens maintenance solutions have provided good cleaning and antibacterial effects on contact lenses.

However, wearing contact lenses for a long time is prone to eye fatigue and discomfort. The conventional contact lens maintenance solution cannot effectively improve the above situation. Therefore, there is still a need for a contact lens maintenance solution that can eliminate eye contact fatigue discomfort of a contact lens user.

It is an object of the present invention to provide a liquid composition for a contact lens which allows a user to eliminate or soothe eye fatigue when using a contact lens, and at the same time has a moisturizing function of the contact lens.

According to an embodiment of the present invention, the liquid composition for a contact lens comprises at least 1×10 ^-5 % to about 3% by weight of one or more vitamins, and the concentration by weight is about 5×10 ^{-3 .} % to about 1.0% of one or more hydrophilic polymers, at a concentration of from about 1 x 10 ^-3 % to about 1% by weight of one or more surfactants, and a borate buffer solution or phosphate Buffer solution.

According to an embodiment of the invention, the vitamin comprises vitamin A and the concentration of vitamin A is from about 0.01% to about 1% by weight.

According to an embodiment of the invention, the vitamin comprises a vitamin B group, such as vitamin B3, vitamin B6 or vitamin B12, and the vitamin group has a concentration by weight of from about 0.01% to about 1.5%.

According to an embodiment of the invention, the vitamin comprises vitamin E and the concentration of vitamin E is from about 0.01% to about 1% by weight.

According to an embodiment of the present invention, the hydrophilic polymer is selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, hyaluronic acid, hydroxypropylmethylcellulose, and polyethylene glycol. The hydrophilic polymer has a weight percent concentration of from about 0.01% to about 0.1%.

According to an embodiment of the present invention, the interface comprises at least one active agent and TWEEN 80 ^TM GEROPON ^TM SBFA-30, and the weight percent concentration of interface active agent is from about 0.001% to about 0.08%.

According to an embodiment of the invention, the borate buffer solution comprises boric acid, sodium borate, and sodium chloride. The phosphate buffer solution contains sodium monohydrogen phosphate, sodium dihydrogen phosphate, and sodium chloride.

The description of the embodiments of the present invention is intended to be illustrative and not restrictive. The various embodiments disclosed below may be combined or substituted with each other in a beneficial situation without further description or description. In the following description, numerous specific details are set forth However, embodiments of the invention may be practiced without these specific details.

The present invention discloses a liquid composition for a contact lens that can be used in hard contact lenses and soft contact lenses. The soft contact lens can be, for example, a hydrophilic water gel lens or a silicone soft contact lens.

In normal use, the contact lens is immersed in a liquid composition to provide sufficient contact between the contact lens and the liquid composition. When the contact lens user wants to wear or use the contact lens, the contact lens is taken out of the liquid composition, and then the contact lens is worn on the eyeball. When the contact lens is immersed in the liquid composition, the components of the liquid composition adhere or adhere to the contact lens. When the user wears the contact lens on the eyeball, the component attached or adsorbed on the contact lens enters the eyeball.

The liquid composition of the embodiment of the present invention contains at least a vitamin, a hydrophilic polymer, an interfacial surfactant, and at least one borate buffer solution or a phosphate buffer solution.

Vitamins help to eliminate the eye fatigue of contact lens users. The vitamins in the liquid composition are adsorbed and adhered to the contact lens, and enter the eyeball as the user wears the contact lens, and are absorbed by the eye tissue. on The vitamin may be a water-soluble vitamin or a fat-soluble vitamin. The water-soluble vitamin may be, for example, a vitamin B group; the fat-soluble vitamin may be, for example, vitamin A or vitamin E.

The concentration of the vitamin in the bulk liquid composition is from about 1 x 10 ^-5 % to about 3% by weight. When the concentration of the vitamin in the liquid composition is higher than a certain value, the pH of the liquid composition is affected, and the osmotic pressure of the liquid composition is too high. In this case, if the liquid composition enters the eyeball, the user of the contact lens may feel uncomfortable. On the other hand, when the vitamin concentration of the liquid composition is too low, the effect of eliminating eye fatigue is not produced. Thus, the weight percent concentration of vitamins is from about 1 x 10 ^-5 % to about 3%. From this point of view, the total amount of vitamins added in the embodiment of the present invention allows the pH of the liquid composition to be maintained at about 6.0 to about 8.0, and the osmotic pressure of the liquid composition to be maintained at about 200 mOsm/kg to about 500 mOsm/ Kg is preferably from about 280 mOsm/kg to about 380 mOsm/kg.

In one embodiment, the vitamin comprises vitamin A and the concentration of vitamin A is from about 0.01% to about 1% by weight. Herein, unless otherwise specified, the weight percent concentration is based on the overall liquid composition.

In another embodiment, the vitamin comprises a vitamin B population. In one embodiment, the vitamin comprises vitamin B3 and the concentration of vitamin B3 is from about 0.01% to about 1.5% by weight. In another embodiment, the vitamin comprises vitamin B6 and the weight percent concentration of vitamin B6 is from about 0.01% to about 1.5%. In yet another embodiment, the vitamin comprises vitamin B12 and the concentration by weight of vitamin B12 is from about 0.01% to about 1.5%.

In other embodiments, the vitamin comprises vitamin E and the concentration of vitamin E is from about 0.01% to about 1% by weight.

Hydrophilic polymers can promote contact lenses to absorb more vitamins, while avoiding the rapid loss of vitamins on contact lenses due to tears in the eye. The vitamins in the liquid composition, although adsorbed on contact lenses, are usually limited in their amount of adsorption. The hydrophilic polymer in the liquid composition can effectively increase the adsorption and adhesion of vitamins on the contact lens. Specifically, the hydrophilic polymer in the liquid composition adsorbs on the contact lens and adsorbs with the vitamin, thereby increasing the amount of vitamins adsorbed on the contact lens. In addition, the hydrophilic polymer helps to maintain the vitamins adsorbed on the surface of the contact lens, preventing the tears generated by the eyeball from dissolving and removing the vitamins from the contact lens, resulting in rapid loss of vitamins. Especially when wearing contact lenses, the moment when the contact lens contacts the eyeball is often accompanied by the secretion of a large amount of tears. If the vitamins originally absorbed on the contact lens are not properly maintained, the vitamin will quickly dissolve in the tears and leave the eye with the tears. It is not absorbed by the eyeball. From this point of view, the present invention is not merely a simple addition of vitamins, but an interaction between a vitamin and a hydrophilic polymer. More specifically, the technical content of the embodiments of the present invention relates to a biochemical system formed by vitamins, hydrophilic polymers, contact lenses, eyeballs, and tears. The biochemical system allows the user's eyeball to be effectively absorbed by wearing contact lenses. Vitamins.

The hydrophilic polymer may be, for example, polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), hyaluronic acid (HA), hydroxypropylmethylcellulose (HPMC) or polyethylene. Polyethylene glycol (PEG). In one embodiment, the polyvinyl alcohol and polyvinylpyrrolidone have a weight average molecular weight of from about 2000 g/mol to about 50,000 g/mol, hydroxypropyl group The weight average molecular weight of the base cellulose and hyaluronic acid is from about 50,000 g/mol to about 350,000 g/mol. The above hydrophilic polymer also contributes to the moisturizing of the contact lens.

The concentration of the hydrophilic polymer in the liquid composition can be adjusted according to the type and concentration of the vitamin. In one embodiment, the hydrophilic polymer has a weight percent concentration of from about 5 x 10 ^-3 % to about 0.5%, preferably from about 0.01% to about 0.1%, in order for the contact lens to adsorb a sufficient amount of vitamins.

An appropriate amount of surfactant can be added to the liquid composition of the contact lens to clean the contact lens. The type and concentration of the added surfactant may be as long as it does not irritate the user's eye and is not harmful to human health. For ^{example, TWEEN 20 TM, TWEEN 80 TM} , GEROPON TM SBFA-30 or TETRONIC 1107 ^TM, the weight percent concentration of interface active agent is from about 1 × 10 ^-3% to about 1%, more specifically from about 1 × 10 ^-3 % to about 0.1%.

The inventors of the present invention have found that certain surfactants not only have the function of cleaning contact lenses, but also promote the adsorption of more vitamins by the contact lenses. In one embodiment, the interface active agent comprises at least one active agent is TWEEN 80 ^TM interface and GEROPON ^TM SBFA-30, which can further increase the amount of adsorption on contact lenses vitamins and cleaning contact lenses while both functions. In this embodiment, the concentration of the surfactant in the bulk liquid composition is from about 1 x 10 ^-3 % to about 0.08%, preferably from about 0.002% to about 0.01%. Further, TWEEN 80 ^TM and GEROPON ^TM SBFA-30 interface active agent can increase the solubility of fat-soluble vitamins in the liquid composition.

A borate buffer solution or a phosphate buffer solution is used to provide a stable pH environment. For example, the borate buffer solution may comprise boric acid, sodium borate to And sodium chloride. The phosphate buffer solution may comprise sodium monohydrogen phosphate, sodium dihydrogen phosphate, and sodium chloride. Further, the above salt buffer solution contains an appropriate amount of sodium chloride to maintain the osmotic pressure of the above liquid composition in an appropriate range, for example, from about 200 mOsm / Kg to about 500 mOsm / Kg.

In one embodiment wherein the liquid composition comprises a borate buffer solution, the concentration by weight of sodium chloride in the bulk liquid composition is from about 0.35% to about 1.05%, and the concentration by weight of boric acid is from about 0.20% to About 0.70%, the weight percent concentration of sodium borate is from about 0.01% to about 0.7%.

In one embodiment wherein the liquid composition comprises a phosphate buffer solution, the weight percent concentration of sodium chloride in the overall liquid composition is from about 0.40% to about 1.20%, and the weight percent concentration of sodium monohydrogen phosphate is about From 0.10% to about 0.70%, the weight percent concentration of sodium dihydrogen phosphate is from about 0.01% to about 0.70%.

In other embodiments, the above liquid composition may further comprise a sufficient amount of antimicrobial agent, for example, less than 3 ppm of polyhexamethylene biguanide (PHMB) may be added, as is known in the art.

Several representative embodiments are listed below.

Example 1

Example 2

Example 3

Example 4

Example 5

Balance water

Although the present invention has been disclosed in the above embodiments, it is not intended to limit the present invention, and the present invention can be modified and modified without departing from the spirit and scope of the present invention. The scope is subject to the definition of the scope of the patent application attached.

Claims (10)

A liquid composition for a contact lens comprising: a concentration by weight of from about 1 x 10 ^-5 % to about 3% of a vitamin; a concentration by weight of from about 5 x 10 ^-3 % to about 1.0% of a hydrophilicity a polymer, wherein the hydrophilic polymer is selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, hyaluronic acid, hydroxypropylmethylcellulose, and polyethylene glycol; and the concentration by weight is about 1×10 ^-3 From about 1% to about 1% of the surfactant; and a borate buffer solution or a phosphate buffer solution. The liquid composition of claim 1, wherein the vitamin comprises vitamin A, and the vitamin A is present in a concentration of from about 0.01% to about 1% by weight. The liquid composition of claim 1, wherein the vitamin comprises vitamin B3, and the vitamin B3 is present in a concentration of from about 0.01% to about 1.5% by weight. The liquid composition of claim 1, wherein the vitamin comprises vitamin B6, and the vitamin B6 has a concentration by weight of from about 0.01% to about 1.5%. The liquid composition of claim 1, wherein the vitamin comprises vitamin B12, and the vitamin B12 is present in a concentration of from about 0.01% to about 1.5% by weight. The liquid composition of claim 1, wherein the vitamin comprises vitamin E, and the vitamin E is present in a concentration of from about 0.01% to about 1% by weight. The liquid composition of claim 1, wherein the hydrophilic polymer has a concentration by weight of from about 0.01% to about 0.1%. The liquid composition according to the request of the item 1, wherein the interface comprises at least one active agent and TWEEN 80 ^TM GEROPON ^TM SBFA-30, the interface and the weight percent concentration of the active agent of from about 0.001% to about 0.08%. The liquid composition of claim 1, wherein the borate buffer solution comprises boric acid, sodium borate, and sodium chloride. The liquid composition of claim 1, wherein the phosphate buffer solution comprises sodium monohydrogen phosphate, sodium dihydrogen phosphate, and sodium chloride.