TWI421107B - Medicament delivery device - Google Patents

Description

Drug delivery device

The present invention relates to a drug delivery device, particularly a drug injector that is secured by a lid to enhance safety and operability.

A solution for assembling the drug delivery device as much as possible in advance is a delivery device that delivers the drug by a delivery member such as a pre-attached injection needle. This solution causes the end of the needle to protrude into the container, with the disadvantage that the drug may react with the material of the delivery member after exposure for a period of time. Therefore, it is preferable that the conveying member outside the container has a rear end portion before performing the conveying. To simplify the action of the injection, some devices only need to be pressed against the injection site, without the need to press the button to inject, so that the injection needle punctures the injection site and allows the device to perform the injection. Therefore, the transport procedure is simplified by at least one step.

One such device is described in document EP 1 349 590 B. A syringe has many features to facilitate the operation of the syringe. Puncture and injection can be performed by simply pressing the proximal end of the needle sleeve against the delivery zone, causing the needle guard to move toward the end, allowing the needle to puncture the injection zone and initiate the injection procedure. After the injection is performed, the syringe is removed, and the needle sleeve is withdrawn and locked around the needle.

However, prior art solutions have the disadvantage that they are sometimes unreliable and can be misused or unfortunate. Therefore, it is very important to operate the drug delivery device artificially, and there are many basic principles that can be used to enhance existing solutions. An important safety point of view is when the drug delivery device is operated, the injection actuator is locked before the drug delivery device is ready for use. Document US6,893,420 The dew device is provided with a locking device to lock the latch to prevent the automatic puncture device and the injection device from loosening prior to completion of drug mixing. However, this device suffers from the disadvantage that the user must actively remove the lock device after the mixing is completed, which is an unnecessary step, especially when the device is used urgently. There is therefore a need for an arrangement that provides advances in safe operation and advances in drug treatment, such as: the drug can be stored in a pre-assembled device that is transported and does not degrade by reaction with the delivery member material for a period of time while maintaining reliability, Safe and easy to use.

The primary object of the present invention is to provide a drug delivery device that is reliable, safe, and easy to use during operation. This object can be achieved by a drug delivery device comprising a tubular housing having a proximal end and an opposite end; the activation device Slidably and coaxially located within the tubular outer casing and including a proximal tubular contact member; a first resilient member located at the end of the activation device between the annular ledge of the tubular outer casing and the annular ledge of the activation device; The container carrier is coaxially located within the activation device and fixedly attached to the tubular housing; an activation member is interactively coupled to the activation device and holds the activation device, and the first resilient member is in a pre-compressed state, wherein the drug delivery device further comprises: A conveying member includes a positioning member fixedly coupled to the container tray, a hub coaxially moved within the positioning member, and an injection needle having a proximal end and an opposite end, an inner cover being interactively coupled to the hub and the positioning member, The outer cover is coaxially attached to the inner cover; wherein when the activation device and the first resilient member are in a pre-compressed state The outer cover of the inner cap relative rotation; and a cover member coupled coaxially slidably but rotatably locked in The inner cover is adjacent to the proximal annular operating member, and wherein the cover coupling member is in contact with the outer cover when the activation device and the first resilient member are released from the pre-compressed state.

According to a primary aspect of the present invention, the drug container tray further includes a drug container having a drug therein, the drug container further comprising at least one slidable stopper and a film.

According to another aspect of the invention, the drug delivery device further includes a drive device that is interactively coupled to the activation device or activation member to drive the slidable stopper.

In accordance with another aspect of the present invention, an activation device includes a tubular activation member and an intermediate longitudinal lock member, wherein the proximal annular contact member is coaxially located within the proximal end of the tubular activation member, and wherein the intermediate longitudinal lock member further includes a The first cooperating device is interactively coupled to the first cooperating device of the respective actuating member to maintain the actuating device and the first resilient member in a pre-compressed state.

According to another aspect of the invention, the first cooperating means is a radially outwardly extending projection and the first cooperating means of the respective first actuating member is a radially inwardly extending projection.

According to another aspect of the present invention, the driving device includes a tubular operating member having an internal cooperating device on an inner surface thereof, and an external cooperating device on an outer surface thereof, a plunger rod, and a second elastic member pre-compressed to the column Inside the plug stem, and a plunger rod tow the frame member.

According to another aspect of the present invention, the intermediate longitudinal lock member further includes a second cooperating device that is interactively coupled to the outside of the tubular operating member for cooperation Device.

According to another aspect of the invention, the second cooperating means is a radially inwardly extending projection and the external cooperating means is a grooved track.

According to another aspect of the present invention, the plunger rod includes a third cooperating device releasably coupled to the internal cooperating device of the tubular operating member (when the drug container is a single drug cartridge) to support the plunger rod And the second elastic member is in a pre-compressed state such that when the actuating device is pressed against the delivery portion, the tubular operating member is rotated, whereby the plunger rod is released from the driving device and is proximally biased by the force of the second elastic member The driving is such that the plunger rod exerts a pressure on the slidable stopper, whereby the medicine is discharged from the conveying member.

According to another aspect of the present invention, the plunger rod includes a third cooperating device that is first releasably coupled to the internal cooperating device of the actuating member, and then releasably coupled to the internal cooperating device of the tubular operating member (when the drug When the container is a double cartridge, when the actuation member is manually operated, the plunger rod is released from the activation member and is moved proximally by the force of the second elastic member, so that the plunger rod is pressed against the slidable stopper Above, drug mixing is performed until the third cooperating device abuts the internal cooperating device of the tubular operating member. The tubular operating member is rotated when the actuating device is pressed against the delivery portion, whereby the plunger rod is released from the tubular operating member and is driven proximally by the force of the second resilient member such that the plunger rod is pressed against The stopper can be slid and the drug discharged through the delivery member.

According to another aspect of the invention, the device further includes a variable dose tubular member fixedly coupled to the activation member and rotatable relative to the tubular operational member.

According to another aspect of the invention, the device further comprises a variable dose tubular structure The piece is fixedly coupled to the activation member and rotatable relative to the tubular operating member, wherein the variable dose tubular member includes an internal dose cooperating device.

According to another aspect of the invention, the plunger rod includes an additional fourth cooperating device on its outer surface that cooperates with the interior of the tubular operating member, and wherein the third cooperating device of the plunger rod is releasably coupled to The interior of the actuating member cooperates with the device such that when the actuating member is manually operated, the plunger rod is released from the actuating member and is moved proximally by the force of the second resilient member such that the plunger rod exerts pressure on the slidable stopper To perform drug mixing until the fourth cooperating device abuts the internal cooperating device of the tubular operating member, and when the actuating member is manually operated to select a predetermined dose, the variable dose tubular member also rotates so that the plunger rod The distance between the third cooperating device and the internal dose cooperating device on the inner surface of the variable dose member determines the dose to be delivered.

According to another aspect of the present invention, the actuating device is pressed against the delivery portion such that the tubular operating member is rotated, whereby the fourth cooperating device is released from the internal cooperating device of the tubular operating member, allowing the plunger rod to be The force of the two elastic members is driven proximally such that the plunger rod exerts a pressure on the slidable stopper and the set dose of medicament is discharged through the delivery member until the third cooperating device of the plunger rod is adjacent to the variable dose The internal dose on the inner face of the member cooperates with the device.

According to another aspect of the invention, the lid attachment member is an intermediate annular member having a cooperating means for engaging the annular cooperating means on the inner sheath of the respective outer cover for rotating the outer cover.

Pre-assembled drug delivery device at the beginning of the needle without puncture film In the initial state, the reaction between the drug and the material of the conveying member can be avoided. Furthermore, the use of the lid attachment member prevents inadvertent activation of the drug delivery device, since it is not possible to initiate injection of the internal drug prior to activation of the drug delivery device. These and other advantages of the invention will be apparent from the description and appended claims.

Embodiments of the invention will be described in detail below. In the current application, the terminus means the drug delivery device or the member that is furthest from the user at the time of injection. Correspondingly, the proximal side means the drug delivery device or the member closest to the user at the time of injection.

1A is a simplified exploded perspective view of a drug delivery device 100 in accordance with the present invention. The pre-assembled drug injection device 100 illustrating the initial and non-initial states in Fig. 1A has an outer cover 410 mounted thereon. The drug delivery device 100 further includes a tubular housing 110 having a proximal end 111 and an opposite end 112. The activation device includes a tubular activation member 120 that slides coaxially within the tubular housing 110, an intermediate longitudinal locking member 119 and a proximal annular contact. Member 121. The drug delivery device 100 also includes a first resilient member 117 (Fig. 1B) located at the end of the activation device between the annular ledge 202 of the tubular outer casing 110 and the annular ledge 225 of the intermediate longitudinal lock member 119 to activate the device Move in the near direction. The drug delivery device 100 further includes a drug container tray 150 coaxially located within the tubular activation member 120 and fixedly attached to the tubular housing 110 (the radial extension 234 extends beyond the opening 113 in the corresponding tubular housing 110) (Fig. 2F ). The drug delivery device 100 also has a drug container 130 located within the drug container tray 150 and having at least one drug container therein Slide the stoppers 131, 132. In an embodiment of the invention, the drug container is a drug film 133. The drug delivery device 100 further includes a driving device including a tubular operating member 118 having internal cooperating devices on its inner surface and external cooperating devices on its outer surface, a plunger rod 116, and a second elastic member 115 pre-compressed Inside the plunger rod, and a plunger rod support member 114 (Fig. 1B). The drug delivery device 100, in turn, includes an activation device, hereinafter referred to as an activation member 160, located at the end of the tubular housing 110 and used to activate the drug delivery device 100, such as to prepare the drug delivery device for use. The activation member 160 is a knob that is rotatable about a shaft extending from the distal end of the drug delivery device 100 to the proximal end. The preferred embodiment of the present invention is a rotatable tubular operating member 118 positioned between the container carrier 150 and the activation member 160. The drug delivery device 100 in turn includes a delivery member 140.

2A shows a detailed perspective view of a tubular housing 110 having a corresponding opening 113 to receive a radial extension 234 (FIG. 2F) to securely attach the drug container tray 150 to the tubular housing 110. Figure 2A again illustrates a second opening 201 for the user to see the injection procedure. And FIG. 2A discloses an annular ledge 202 to support the first resilient member 117 in a pre-compressed state (between the tubular outer casing 110 and the intermediate longitudinal lock member 119).

Figure 2B shows a perspective view of a more detailed portion of the plunger rod assembly. The plunger rod assembly includes a plunger rod support member 114, a second elastic member 115, and a plunger rod 116. The outer radial face of the plunger rod 116 is provided with a third cooperating means, such as a projection 235, acting with the internal cooperating means (the ledge 236 of the actuating member 160) to maintain the plunger rod 116 in a pre-compressed, non-starting manner. status.

FIG. 2C shows a perspective view of the tubular operating member 118. The tubular operating member 118 includes external cooperating means (e.g., at least one groove 210, 211, 212 on the outside of the tubular operating member 118) such that when the intermediate longitudinal locking member 119 is axially moved, a second cooperating device (middle) The radially inwardly extending projections 222) of the longitudinal lock members 119 are guided into the at least one recess 210, 211, 212 to force the tubular operating member 118 to rotate, so that the interconnected tubular actuating members 120 move axially. Moreover, in an embodiment, the drug delivery device 100 includes a lock device that is interactively coupled to the intermediate longitudinal lock member 119 and the tubular activation member 120. Preferably, the locking device is a resilient tongue 213 located on the tubular operating member 118. The resilient tongue 213 is used to lock the second cooperating device, such as the radially inwardly extending projection 222 of the intermediate longitudinal locking member 119 when the activation device is fully extended in the proximal direction. 2C also shows a radially inwardly extending projection 216 on the inner face of the tubular operating member for locking a radially outwardly extending resilient projection 203 on the end of the plunger rod 116 (when the plunger rod 116 passes through) At the end of the tubular operating member 118, such as when the plunger rod 116 is moved proximally. 2C also depicts a cross-sectional perspective view of the internal cooperating device 215 of the tubular operating member 118. The internal cooperating device 215 includes a ledge and a recess.

In an embodiment of the invention, when the drug container 130 is a single cartridge, the third cooperating device 235 of the plunger rod 116 is releasably coupled to the internal cooperating device 215 of the tubular operating member 118 to maintain the plunger rod The 116 and second resilient member 115 are in a compressed state such that when the activation device 119, 120 is pressed against the injection, the tubular operating member 118 is rotated whereby the third cooperating device 235 is removed from the tubular operating member 118. The internal cooperating device 215 is loosened, and the plunger rod is driven proximally by the force of the second elastic member 115, so that the plunger rod 116 is biased on the slidable stopper 131, whereby the medicine is taken from the conveying member 140 discharge.

In an embodiment of the invention, the plunger rod 116 of the drug delivery device 100 includes a third cooperating device 235 that is first releasably coupled to an internal cooperating device 236 of the activation device 160 and releasably coupled to The internal cooperating device 215 of the tubular operating member 118 (when the actuating device 160 is manually operable), the plunger rod 116 is released from the actuating device 160 and is moved proximally by the force of the second resilient member 115 such that the plunger The rod 116 applies a force on the slidable stoppers 131, 132 to effect drug mixing until the third cooperating device 235 abuts the internal cooperating device 215 of the tubular operating member 118, and when the tubular operating members 119, 120 are opposed to the injection When pressed, the tubular operating member is rotated whereby the third cooperating device 235 is released from the internal cooperating device 215 of the tubular operating member 118 and the plunger rod is biased by the force of the second resilient member 115 The end drive is such that the plunger rod 116 exerts a force on the slidable stoppers 131, 132 and the medicament is discharged via the delivery member 140.

In an alternate embodiment of the invention, a variable dose tubular member (not labeled) is fixedly coupled to the activation member 160 and rotatable relative to the tubular operational member 118. The variable dose tubular member includes an internal dose cooperating device to form a stepped ledge. Further, the plunger rod 116 includes a fourth cooperating device outside thereof. When the drug container 130 is a dual chamber cartridge, the third cooperating device 235 of the plunger rod 116 is releasably coupled to the internal cooperating device 236 of the activation device 160 such that when the activation device 160 is manually operated When the plunger rod 116 is released from the activation device 160 and is moved proximally by the force of the second elastic member 115, the plunger rod 116 is pressed against the slidable stoppers 131, 132 to mix the drugs until the fourth The cooperating device abuts the internal cooperating device 215 of the tubular operating member 118. When the activation device 160 is manually operated to select a predetermined dose, the variable dose tubular member also rotates such that between the third cooperating device 235 of the plunger rod 116 and the stepped ledge on the inner surface of the variable dose member The distance determines the dose to be delivered. When the tubular activation device 119, 120 is pressed against the injection site, the tubular operating member 118 is rotated whereby the fourth cooperating device is released from the internal cooperating device 215 of the tubular operating member 118 and the plunger rod 116 The force is applied to the proximal end by the force of the second elastic member 115, so that the plunger rod 116 is pressed against the slidable stoppers 131, 132, and the set dose of the medicine is discharged through the conveying member 140 until the third of the plunger rod 116 The cooperating device 235 is adjacent to the stepped ledge on the inner face of the variable dose member.

FIG. 2D depicts a perspective view of the tubular activation member 120. The tubular activation member 120 includes a recess or an opening 224 for receiving a protrusion 223 of the respective intermediate longitudinal lock member 119 to securely attach the intermediate longitudinal lock member to the tubular activation member 120. The tubular activation member 120 in turn includes an annular contact member 121 for pressing against the patient's skin and an opening 201 for viewing the drug delivery process.

2E is a perspective view of the intermediate longitudinal lock member 119. The intermediate longitudinal lock member 119 includes a first cooperating device 221 for cooperating with the cooperating device 301 of the respective actuating member 160 to maintain the actuating device and first resilient member 117 in a pre-compressed state. In an embodiment, the intermediate longitudinal lock The first co-cooperating device 221 of the member 119 is a projection that is located within the end annular wall of the intermediate longitudinal locking member 119, and the respective first cooperating device 301 is a radially outwardly extending projection.

2F is a detailed perspective view of the drug container tray 150 showing an opening 233. In an embodiment of the invention, a corresponding opening 233 is located on the other side of the drug container carrier 150 (not labeled). The drug container tray 150 in turn includes a radial extension 234 for fixedly attaching the drug container tray 150 to the tubular housing 110 via a respective opening 113 (Fig. 2A). In an embodiment of the invention, there are two radial extensions 234 for fixedly attaching the drug container tray 150 to the tubular outer casing 110 via respective openings 113. The drug container tray 150 further includes an opening 233 for mating with a support device of the respective transport member (Fig. 4A), and the drug container tray 150 also has a predefined contour 231, 232 for attachment to the intermediate longitudinal lock member 119. Within the corresponding contour.

2G illustrates an annular cooperating device 202 in which the first resilient member 117 is interactively coupled to the tubular outer casing 110 in a pre-compressed state and an annular ledge 225 coupled to a respective cooperating device (eg, intermediate longitudinal locking member 119). ) perspective view.

FIG. 3A depicts a side view of the activation member 160. The activation member 160 has a securing means 302 (e.g., an elastic tongue) to attach the activation member 160 to the fixture of the end of the respective tubular outer casing 110. The activation member 160 in turn includes a first cooperating device 301 to interactively couple the activation member 160 to a cooperating device 221 of a respective intermediate longitudinal locking member 119. In the embodiment of the present invention, the first cooperating device 301 is a sudden The cooperating means 221 of the corresponding intermediate longitudinal locking member 119 is also a projection.

FIG. 3B is a cross-sectional perspective view of the activation member 160. The internal cooperating device is shown as a ledge 236 that cooperates with the third cooperating device 235 of the corresponding plunger rod 116 in a pre-compressed state.

4A is a perspective view of a delivery member 140 including a positioning member 430 fixedly coupled to the drug container tray 150; a hub 421 having an injection needle having a proximal end 424 and an opposite end 425, including a first A coupling device 423, such as a threaded version on the outer surface of the hub 421 for interactively coupling the first coupling means 431 of a respective positioning member 430; an inner cover 416 is interactively coupled to the hub and the positioning member; an exterior The cover 410 is coaxial with the inner cover, wherein the outer cover is rotatable relative to the inner cover when the activation device and the first resilient member are in a pre-compressed state; and a cover coupling member 413 is slidable coaxially but rotatably locked to the inner cover 416 and adjacent the end annular contact member 121, and wherein the cover coupling member also interacts with the outer cover when the activation device and the first resilient member are released from the pre-compressed state. The hub 421 also includes a second coupling means 422, such as a radial groove shape at the proximal end of the hub 421, that is interactively coupled to the respective second coupling means 415 (Fig. 4B), such as the radial direction of the inner cover 416. The shape of the inner extension. There are four second coupling devices 415, 22 in the figure. However, the number of coupling devices 415, 422 is optional as long as the desired function can be achieved, such as by rotational movement from the inner cover 416 to the hub 421 while simultaneously moving the hub 421 toward the end. The hub 421 is positionally movable within the positioning member 430. Moving from the hub 421 to the end, The distal injection needle end 425 pierces the membrane 133. The lid attachment member 413 is an intermediate annular member with a cooperating means that engages an annular common device 417 on the inner sheath of the respective outer cover to rotate the outer cover.

Figure 4B is a perspective view of the outer cover 410 as seen from the end. The outer cover 410 includes one or more radially outwardly extending rotating members 411 (preferably two, three, or four wing members) on the outside thereof for easy gripping when the outer cover 410 is to be turned off . An alternative is that the outer cover 410 is provided with a progressive cross-sectional diameter attached to the proximal end of the tubular activation member 120 (when the cover 410 is attached to the tubular delivery device 100). 4B is a third coupling device 432 (FIG. 4A) in which the inner cover 416 has a third coupling means 414 (eg, internally threaded) that is interactively coupled to the respective positioning member 430. The third coupling means 414 is located on the inner face of the outer sheath of the inner cover 416 facing the end and is of a cylindrical shape. It is to be noted, however, that the threads 423, 432 between the inner side of the inner cover 416 and the outer surface of the positioning member 430 and the threads 423, 431 between the inner surface of the hub 421 and the positioning member 431 have different oblique directions. When the user begins to rotate the outer cover 410 and engages the inner cover by the cover coupling member 430, this rotation causes the hub 421 to be screwed into the positioning member 430, whereby the distal end 425 of the injection needle pierces the film 133 of the drug container 130, and due to the thread The tilting direction is different and the inner cover 416 is turned away, so the outer cover and the inner cover are removed. Alternatively, the thread can be tilted more preferably, and the hub 421 can be rotated at a small angle with a major longitudinal movement of the end to prevent rotation of the needle tip 425 or drilling into the membrane 133 as much as possible. At the same time, the thread inclination between the cover 410 and the positioning member 430 is preferably selected so that the user only needs to rotate the cover 410 a half turn to perform the operation. Do not change the grip mode in order to complete the operation. The lid coupling member 413 is also illustrated in FIG. 4B to lock the outer lid 410 to the inner lid 416. When the lid coupling member 413 is in the unlocked position, the outer lid 410 is rotatable relative to the inner lid, and the outer lid 410 cannot be removed. Therefore, when the lid coupling member 413 is in the unlocked position, it is impossible to use the drug delivery device 100. When the actuating member 160 is rotated, a protrusion 221 of the outer annular wall of the intermediate longitudinal lock member 119 is released from the cooperating protrusion 301 of the actuating member 160 (Figs. 7A and 7B), and the actuating device is first The force of the elastic member 117 is forced to move proximally, so that the annular contact member 121 that is in contact with the cover coupling member 413 pushes the cover coupling member 413 toward the proximal end, so that the outer cover is locked to the inner cover, which is the cover coupling member 413 The locked position (refer to Figures 6A to 6C).

Figure 5 is a cross-sectional perspective view of the delivery assembly. The display positioning member 430 is fixed to the drug container tray 150, the outer cover 410, the inner cover 416, and the hub 421.

Figure 6A illustrates a cross-sectional side view of the outer cover 410 and positioning member 430 assembly in an initial mode with the cover coupling member 413 in an unlocked position.

Figure 6B illustrates a cross-sectional side view of the outer cover 410 and positioning member 430 assembly in a mixed or preliminary mode in which the cover coupling member 413 is axially urged proximally to the locked position by the activation device.

6C illustrates a cross-sectional side view of the outer cover 410 and the positioning member 430 assembly in a pre-flush mode in which the cover coupling member 413 is maintained in the locked position and the outer cover 410 is removed, causing the hub 421 to move axially toward the end, The distal injection needle 425 is forced to puncture the film 133 of the drug container 130.

Figure 7A illustrates a perspective view of the activation member 160 in an initial and non-activated state, interactively coupled to the intermediate longitudinal lock member 119. In the initial state, the first cooperating means of the intermediate longitudinal locking member 119 engages with the first cooperating means of the respective actuating member 160.

Figure 7B is a perspective view of the activation member 160 in a second state (activated state), interactively coupled to the intermediate longitudinal lock member 119. In the second state, the first cooperating means of the intermediate longitudinal lock member 119 are released from the engaged position to the first cooperating means of the respective actuating member 160.

Figures 8A through 8C illustrate the drug delivery device 100 from an activated state (Figure 8A) (where the distal injection needle end 425 (Figure 4A) has pierced the membrane 133 (Figure 1A) and the drug delivery device 100 is in a ready state) via Figure 8B ( Where the true injection status is indicated, a proximal injection needle end 424 is shown to be ready to expel the drug), and finally to Figure 8C (showing the locked state of the drug delivery device 100, such as: the injection has been completed).

When the drug delivery device 100 is ready for use and the user presses the proximal end of the skin against the skin (eg, the annular contact member 121), the tubular activation member 120 moves toward the end relative to the tubular housing 110 and is in the process of relative movement. In the middle, the proximal end of the needle 425 is manually punctured. When the tubular activation member 120 will reach the extreme end position relative to the tubular housing 110, the injection has been completed; for example, when the tubular activation member 120 passes the injection position a predetermined distance (near the extreme end position), the injection state is reached. This puncture and injection status is shown in Figures 8A through 8C. After the injection is completed, the user removes the drug delivery device 100 from the skin, thereby allowing the tubular activation member 120 to be The force of an elastic member 117 moves proximally relative to the tubular outer casing 110 and finally reaches an end state, such as a locked state. In the locked state, the tubular activation member 120 is once again in the most proximal position (Fig. 8C). In this state, the proximal end of the tubular activation member 120 completely protects the proximal injection needle end 424 and the tubular activation member 120 is also locked in this position to prevent inadvertent needle sticking of the proximal injection needle end 424. Therefore, in order to activate the drug delivery device 100, the user must press the annular contact member 121 against the skin. This releases the plunger rod 116 in a proximal direction relative to the tubular housing 110 by the force of the second resilient means 115 by means of a coupling engagement means. The plunger rod thus forces the slidable stoppers 131, 132 to move proximally relative to the tubular housing 110, allowing the medicament to be expelled.

EXAMPLES Described herein is to prevent the user from inadvertently activating the drug delivery device 100 prior to unmixing the drug within the drug container 130.

The embodiments and the drawings described above are only to be considered as limiting examples of the invention, and the invention may be modified in many ways within the scope of the patent.

100‧‧‧ drug delivery device

110‧‧‧Shell

111‧‧‧ Near end

End of 112‧‧‧

113‧‧‧ openings

115‧‧‧Second elastic member

116‧‧‧Plunger rod

118‧‧‧Tubular operating components

119‧‧‧Intermediate longitudinal locking members

120‧‧‧Tubular starting member

121‧‧‧Circular contact members

130‧‧‧Drug containers

131‧‧‧slidable stopper

132‧‧‧slidable stopper

133‧‧‧film

140‧‧‧Transporting members

150‧‧‧ Container trailer

160‧‧‧Starting device/first starting member

202‧‧‧Ring ledge

210‧‧‧External co-cooperative devices

211‧‧‧ External co-cooperative devices

212‧‧‧External co-cooperative devices

215‧‧‧Internal cooperating devices

221‧‧‧First co-cooperative device

222‧‧‧Second joint cooperative device

225‧‧‧Ring ledge

235‧‧‧ Third joint cooperation device

236‧‧‧Internal cooperating devices

301‧‧‧First co-cooperative device

410‧‧‧External cover

413‧‧‧Cover joint member

416‧‧‧Interior cover

417‧‧‧Circular cooperative device

421‧‧ ‧ hub

End of 425‧‧

DETAILED DESCRIPTION OF THE INVENTION In the following detailed description, reference is made to the drawings in which: FIG. 1A is a perspective view of a drug delivery device in accordance with the present invention.

Figure 1B is an exploded view of the internals of the drug delivery device.

2A is a perspective view of a tubular outer casing of a drug delivery device in accordance with the present invention.

Figure 2B is a perspective view of a plunger rod of a drug delivery device in accordance with the present invention.

2C is a perspective view of a tubular operating member of the drug delivery device.

2D-E are perspective views of the activation device.

Figure 2F is a perspective view of the drug container tray.

2G is a detailed perspective view of the first elastic member pre-compressed.

Figure 3A is a side elevational view of the activation device of the drug delivery device in accordance with the present invention.

Fig. 3B is a cross-sectional perspective view of the starting device.

4A is a perspective view of a delivery device assembly of a drug delivery device in accordance with the present invention.

Figure 4B is a perspective view of the outer cover, cover attachment member and inner cover as seen from the end.

Figure 5 is a cross-sectional perspective view of the delivery device.

6A-C are cross-sectional side views of the lid and delivery device assembly in different modes of operation.

7A-B are side views of the activation device in different modes of operation.

8A-C are side views of the drug delivery device in different modes of operation.

100‧‧‧ drug delivery device

110‧‧‧Shell

111‧‧‧ Near end

End of 112‧‧‧

113‧‧‧ openings

120‧‧‧Tubular starting member

121‧‧‧Circular contact members

130‧‧‧Drug containers

131‧‧‧slidable stopper

132‧‧‧slidable stopper

133‧‧‧film

140‧‧‧Transporting members

150‧‧‧ Container trailer

160‧‧‧Starting device

410‧‧‧External cover

Claims (15)

A drug delivery device (100) comprising: a tubular outer casing (110) having a proximal end (111) and an opposite end (112); the activation device is slidably and coaxially located within the tubular outer casing (110) and includes a proximal portion An end tubular contact member (121); a first resilient member (117) located at the end of the actuating device (112), an annular ledge (202) of the tubular outer casing (110) and an annular ledge (225) of the actuating device A drug container tray (150) is coaxially located within the activation device and fixedly attached to the tubular housing (110); an activation member (160) is interactively coupled to the activation device and holds the activation device, and is first resilient The member is in a pre-compressed state; characterized in that the drug delivery device (100) further comprises: a conveying member (140) comprising a positioning member (430) fixedly coupled to the container tray (150), a hub (421) coaxially moving The positioning member is provided with an injection needle having a proximal end (424) and an opposite end (425), an inner cover (416) is interactively coupled to the hub and the positioning member, and an outer cover (410) is coaxially attached to the interior a cover; wherein when the starting device and the first elastic member are in a pre-compressed state, the outer The cover is rotatable relative to the inner cover; and a cover attachment member (413) is slidable coaxially but rotatably locked to the inner cover (416) and adjacent to the proximal annular operating member (121), and wherein the activation device The cover coupling member is in contact with the outer cover when the first elastic member is released from the pre-compressed state. The drug delivery device (100) of claim 1, wherein the drug container tray further comprises a drug container (130) having a drug therein, the drug container further comprising at least one slidable stopper (131, 132) and a Film (133). The drug delivery device (100) of claim 2, further comprising a drive device, is interactively coupled to the activation device or activation member (160) to drive the slidable stopper. The drug delivery device (100) of claim 3, wherein the activation device comprises a tubular activation member (120) and an intermediate longitudinal lock member (119), wherein the proximal annular contact member is coaxially located at the tubular activation member In the proximal end of the inner surface, and wherein the intermediate longitudinal locking member (119) further includes a first cooperating device (221) that is interactively coupled to the first cooperating device (301) of the respective activation member (160) for activation The device and the first resilient member are maintained in a pre-compressed state. The drug delivery device (100) of claim 4, wherein the first cooperating device (221) is a radially outwardly extending protrusion and the first cooperating device of the corresponding first activation member (160) 301) is a radially inwardly extending projection. The drug delivery device (100) of claim 4 or 5, wherein the driving device comprises a tubular operating member (118) having an internal cooperating device on its inner face and an external cooperating device on its outer face, A plunger rod (116), a second elastic member (115) is pre-compressed in the plunger rod, and a plunger rod drag member (114). The drug delivery device (100) of claim 6 wherein the intermediate longitudinal lock member (119) further comprises a second cooperating device (222) that is interactively coupled to the external cooperating device of the tubular operating member (118) ( 210, 211, 212). a drug delivery device (100) according to item 7 of the patent application scope, The second cooperating device (222) is a radially inwardly extending projection, and the external cooperating device is a grooved track (210, 211, 212). The drug delivery device (100) of claim 7, wherein the plunger rod (116) includes a third cooperating device (235) releasably coupled to the internal cooperating device of the tubular operating member (118) ( 215) (when the drug container (130) is a single drug cartridge), the plunger rod (116) and the second elastic member (115) are pre-compressed so that the starting device (119, 120) is facing When the delivery portion is pressed, the tubular operating member (118) is rotated, whereby the plunger rod (116) is released from the driving device (119, 120) and is driven proximally by the force of the second elastic member (115). The plunger rod (116) is pressed against the slidable stopper so that the medicine is discharged from the delivery member (140). The drug delivery device (100) of claim 7, wherein the plunger rod (116) includes a third cooperating device (235) that is first releasably coupled to the internal cooperating device of the activation member (160) ( 236), then releasably coupled to the internal cooperating device (215) of the tubular operating member (118) (when the drug container (130) is a double cartridge) such that when the activation member (160) is manually operated, The plunger rod (116) is released from the actuating member (160) and is moved proximally by the force of the second resilient member (117) such that the plunger rod (116) is pressed against the slidable stopper (131, 132) Upper to effect drug mixing until the third cooperating device (235) abuts the internal cooperating device (215) of the tubular operating member (118), when the starting device (119, 120) is pressed against the delivery site, The tubular operating member (118) is rotated whereby the plunger rod (116) is released from the tubular operating member (118) and is proximally driven by the force of the second resilient member (115) such that the plunger rod (116) Apply pressure to the slidable stopper (131, 132), and the medicine is discharged through the conveying member (140). The drug delivery device (100) of claim 10, wherein the device further comprises a variable dose tubular member fixedly coupled to the activation member and rotatable relative to the tubular operational member. The drug delivery device (100) of claim 7 wherein the device further comprises a variable dose tubular member fixedly coupled to the activation member and rotatable relative to the tubular manipulation member, wherein the variable dose tubular member comprises an internal dose Cooperate with the device. The drug delivery device (100) of claim 12, wherein the plunger rod includes an additional fourth cooperating device on the outer surface of which cooperates with the interior of the tubular operating member, and wherein the plunger rod is third The cooperating device is releasably coupled to the internal cooperating device of the actuating member such that when the actuating member is manually operated, the plunger rod is released from the actuating member and moved proximally by the force of the second resilient member such that the plunger The rod applies pressure on the slidable stopper to effect drug mixing until the fourth cooperating device abuts the internal cooperating device of the tubular operating member, and when the actuating member is manually operated to select a predetermined dose, the variable dose tubular member The rotation is also such that the distance between the third cooperating device of the plunger rod and the internal dose cooperating device on the inner surface of the variable dose member determines the dose to be delivered. The drug delivery device (100) of claim 13, wherein the activation device is pressed against the delivery portion such that the tubular operating member is rotated, whereby the fourth cooperating device cooperates with the device from the inside of the tubular operating member Open, let the plunger rod drive to the proximal end by the force of the second elastic member Actuating such that the plunger rod exerts pressure on the slidable stopper and the set dose of medicament is discharged through the delivery member until the third cooperating device of the plunger rod abuts the internal dose on the inner surface of the variable dose member Cooperate with the device. The drug delivery device (100) according to any one of claims 1 to 5, wherein the lid attachment member (413) is an intermediate annular member having a cooperating device and an inner sheath of the corresponding outer cover (410) The upper annular cooperating device (417) engages to rotate the outer cover (410).