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TWI319764B - Mercaptoacetylamide derivatives, a process for their preparation and their use - Google Patents

Mercaptoacetylamide derivatives, a process for their preparation and their use

Info

Publication number
TWI319764B
TWI319764B TW091107133A TW91107133A TWI319764B TW I319764 B TWI319764 B TW I319764B TW 091107133 A TW091107133 A TW 091107133A TW 91107133 A TW91107133 A TW 91107133A TW I319764 B TWI319764 B TW I319764B
Authority
TW
Taiwan
Prior art keywords
preparation
mercaptoacetylamide derivatives
mercaptoacetylamide
derivatives
Prior art date
Application number
TW091107133A
Other languages
English (en)
Inventor
A Flynn Gary
Mehdi Shufaath
Franklin Clearman Jack
Dietrich Manfred
Jablonka Bernd
Kleemann Heinz-Wernere
Linz Wolfgang
Seiz Werner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Application granted granted Critical
Publication of TWI319764B publication Critical patent/TWI319764B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW091107133A 2001-04-12 2002-04-10 Mercaptoacetylamide derivatives, a process for their preparation and their use TWI319764B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28330501P 2001-04-12 2001-04-12
GBGB0119305.1A GB0119305D0 (en) 2001-04-12 2001-08-08 Mercaptoacetylamide derivatives,a process for their preparation and their use

Publications (1)

Publication Number Publication Date
TWI319764B true TWI319764B (en) 2010-01-21

Family

ID=23085405

Family Applications (1)

Application Number Title Priority Date Filing Date
TW091107133A TWI319764B (en) 2001-04-12 2002-04-10 Mercaptoacetylamide derivatives, a process for their preparation and their use

Country Status (17)

Country Link
US (1) US6602866B2 (zh)
KR (1) KR100910929B1 (zh)
AR (1) AR034307A1 (zh)
CR (1) CR7074A (zh)
DK (1) DK1381605T3 (zh)
EC (1) ECSP034782A (zh)
GB (1) GB0119305D0 (zh)
GT (1) GT200200069A (zh)
IL (1) IL158289A (zh)
MY (1) MY128226A (zh)
PE (1) PE20021079A1 (zh)
RS (1) RS50919B (zh)
TN (1) TNSN03083A1 (zh)
TW (1) TWI319764B (zh)
UA (1) UA75647C2 (zh)
UY (1) UY27255A1 (zh)
ZA (1) ZA200307096B (zh)

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EP2526095A1 (en) 2010-01-19 2012-11-28 Theravance, Inc. Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
EP2651900B1 (en) 2010-12-15 2015-08-19 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
CA2817368C (en) 2010-12-15 2019-12-31 Theravance, Inc. Neprilysin inhibitors
US8449890B2 (en) 2011-02-17 2013-05-28 Theravance, Inc. Neprilysin inhibitors
EP2675795B1 (en) 2011-02-17 2016-04-20 Theravance Biopharma R&D IP, LLC Substituted aminobutyric derivatives as neprilysin inhibitors
EP2714648B1 (en) 2011-05-31 2017-08-16 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
JP5959075B2 (ja) 2011-05-31 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
EP2714662B1 (en) 2011-05-31 2017-10-11 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
WO2013181332A1 (en) 2012-05-31 2013-12-05 Theravance, Inc. Nitric oxide donor neprilysin inhibitors
WO2013184898A1 (en) 2012-06-08 2013-12-12 Theravance, Inc. Neprilysin inhibitors
AU2013271537B2 (en) 2012-06-08 2017-05-11 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
JP6092390B2 (ja) 2012-08-08 2017-03-08 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
HUE034210T2 (hu) 2013-03-05 2018-02-28 Theravance Biopharma R&D Ip Llc Neprilizininhibitorok
US9585882B2 (en) 2014-01-30 2017-03-07 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
SG11201605965UA (en) 2014-01-30 2016-08-30 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
KR102640906B1 (ko) 2015-02-11 2024-02-27 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 저해제로서 (2s,4r)-5-(5''-클로로-2''-플루오로비페닐-4-일)-4-(에톡시옥살릴아미노)-2-히드록시메틸-2-메틸펜타노익산
EP3259255B1 (en) 2015-02-19 2020-10-21 Theravance Biopharma R&D IP, LLC (2r,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxy-4-[(5-methyloxazole-2-carbonyl)amino]pentanoic acid
MX2018010727A (es) 2016-03-08 2019-01-24 Theravance Biopharma R&D Ip Llc Acido (2s,4r)-5-(5'-cloro-2'-fluoro-[1,1'-bifenil]-4-il)-2-(etoxim etil)-4-(3-hidroxiisoxazol-5-carboxamido)-2-metilpentanoico cristalino, y sus usos.

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RU2124503C1 (ru) 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
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Also Published As

Publication number Publication date
MY128226A (en) 2007-01-31
GB0119305D0 (en) 2001-10-03
UA75647C2 (en) 2006-05-15
RS50919B (sr) 2010-08-31
KR20040008153A (ko) 2004-01-28
US20020193589A1 (en) 2002-12-19
DK1381605T3 (da) 2005-05-09
AR034307A1 (es) 2004-02-18
UY27255A1 (es) 2002-07-31
TNSN03083A1 (en) 2005-12-23
IL158289A (en) 2010-11-30
GT200200069A (es) 2002-12-17
US6602866B2 (en) 2003-08-05
KR100910929B1 (ko) 2009-08-06
YU78703A (sh) 2006-05-25
ECSP034782A (es) 2003-12-01
PE20021079A1 (es) 2003-02-19
CR7074A (es) 2007-12-04
ZA200307096B (en) 2004-09-06

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Legal Events

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MM4A Annulment or lapse of patent due to non-payment of fees