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TWI284639B - A compound having thrombopoietin receptor agonistic effect - Google Patents

A compound having thrombopoietin receptor agonistic effect Download PDF

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Publication number
TWI284639B
TWI284639B TW090101355A TW90101355A TWI284639B TW I284639 B TWI284639 B TW I284639B TW 090101355 A TW090101355 A TW 090101355A TW 90101355 A TW90101355 A TW 90101355A TW I284639 B TWI284639 B TW I284639B
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alkyl
substituted
halogen
iii
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Hiroshi Takemoto
Takeshi Shiota
Masami Takayama
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Shionogi & Co
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    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
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    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

1284639 A7 B7_ 五、發明說明（1 ) 技術領域 (請先閱讀背面之注意事項再填寫本頁) 本發明爲有關具有血栓形成素受體激動作用之化合 物。 背景技術 血栓形成素係由3 3 2個胺基酸而成之多肽細胞分裂 素，藉受體刺激巨核細胞之分化及增殖來亢進血小板之 產生，故可期待爲治療血小板減少症等伴隨血小板數異 常之血液病症之藥劑。編碼血栓形成素受體的基因之 鹼基序列記載於 Proc· Natl· Acad· Sci. 89:5 640-5 644 (1 992 )。對血栓形成素受體有親和性之低分子胜肽 雖爲已知（特開平1 0-72492, W096/40750)，但這些胜肽 衍生物之口服一般並不實用。 對血栓形成素受體有親和性之低分子化合物有1，4-苯并吖庚因衍生物記載於特開平1 1 - 1 477及特開平1 1-152276 〇 構造類似本發明之化合物記載於特開平1 0 - 2 8 7 6 3 4 等，但無記載有關對血栓形成素受體之親和性。 發明之揭示 經濟部智慧財產局員工消費合作社印製 本發明創製具有血栓形成素受體激動作用之醫藥組 成物，提供可口服之血小板生產調節劑。 鑑此，本發明人致力硏究之結果，發現如下式化合物 具有強力血栓形成素受體激動作用，即本發明包括： 1 · 一種具有血栓形成素受體激動作用之醫藥組成物， 內含有效成分爲如下式（I)化合物、其前藥、製藥容 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 五、 經濟部智慧財產局員工消費合作社印製 A7 B7 發明說明（2) 許鹽或這些之媒合物 X^Y^Z^W1 ( I ) [式中X1爲可有取代之芳基、可有取代之芳烷基、可 有取代之雜芳基或可有取代之雜芳烷基； γΐ 爲-NRACO-(CH2)o-2 ‘'一 NRACO -（CH2) 0-2 - V-、 一 NRACO- CRc=CRD —、- V-（CH2)卜β - NRACO-（CH2) 〇- 2-、—V-（CH2)卜5 - CONRA -（CH2) 〇一 2 -、一 CONRA-(CH2) 〇一2 -、一（CH2) 〇-2 - NRA-S02- (CH2) 〇_2 -、-（C η2) ο”- so2~nra一（CH2) 0_2-、—NRA- (CH2) 0一2-、- NRA—co 一 NRA 一 一 NRA 一 CS — NRA 一 —N==c ( sra) nr a-、- NRACSNRaco 一、一 N==c (一 SRA) 一nrA(：〇 —、—nra -（ch2) 1-2-nra-CO-、-NRAC〇NRANRBCO- 或—n = C(-NRARA)-NRAc〇_(其中Ra各自爲η或低烷基；rB 爲Η或苯基；Rc及rd各自爲H、鹵素、可有取代之 低院基、可有取代之低院氧基、可有取代之低烷硫 基、可有取代之低烯基、可有取代之低炔基、可有取 代之芳基、可有取代之雜芳基、可有取代之環烷基、 可有取代之芳烷基、可有取代之雜芳户 ^ 方丨兀基、可有取代 之非芳雜環基、或可有取代之胺基·ν 您，V爲〇或S); Ζ爲可有取代之亞苯基、可有取代 代之單環亞雑芳 基' 可有取代之單環非芳族雜環：：：甚 ^ 绝、或可有取代5 單環環烷二基； 乂代之 w 1爲如下式基 -4- 本紙張尺度適用中國國家標準（CNS)A4規格（21〇 χ 297公釐） I I L I--w— I I I I — — — — — — I— ^ --------I (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 五、發明說明（3 ) v\fv；R3 1 Ο
R6
,0Ra
Ο
OR5
r? ο ο%^〇R5
或 R1 R1 ,〇R9 -ϋ ϋ ϋ I ϋ n ϋI ϋ n I ϋ I 1 I (請先閱讀背面之注意事項再填寫本頁} 經濟部智慧財產局員工消費合作杜印製 (式中R1，R2, R4, r7及r8各自爲 可有取代之低院基、可有取代之低院氧基、可有取代 之低烷硫基、可有取代之低烯基、可有取代之低炔 基、可有取代之方基、可有取代之雜芳基、可有取代 之環院基、可有取代之芳烷基、可有取代之雜芳烷 基、可有取代之非芳雜環基、或可有取代之胺基； R5，R6及R9各自爲Η、鹵素、可有取代之低烷 Η、鹵素 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7_ 五、發明說明（4 ) 基、可有取代之低烯基、可有取代之低炔基、可有取 代之芳基、可有取代之雜芳基、可有取代之環烷基、 可有取代之芳烷基、可有取代之雜芳院基、或可有取 代之非芳雜環基； A1爲可有取代之芳基或可有取代之雜芳基； 虛線表示鍵之有或無存在）]。 詳言之，有關如下2)〜29)。 2 ·如1之具有血栓形成素受體激動作用之醫藥組成物， 其中X1爲可有取代之雜芳基。 3.如1之具有血栓形成素受體激動作用之醫藥組成物， 其中X1爲如下式基
(式中R1G及R11各自爲Η、可有取代之低烷基、羧 基、低烷氧羰基、鹵素、可有取代之胺羰基、可有取 代之雜芳基、或可有取代之芳基；R12爲Η或可有取 代之低烷基）。 4 ·如1之具有血栓形成素受體激動作用之醫藥組成物， 其中X1爲如下式基 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 擊 ϋ· tMM an 1 ϋ— ^ ^ I ^^1 ϋ ϋ ^^1 ^^1 I ^ΡΓ (請先閱讀背面之注咅？事項再填寫本頁) 1284639 Α7 Β7 五、發明說明（5) 4Π
(請先閱讀背面之注意事項再填寫本頁) (式中R1G及R11各同上3)。 5.如1〜4中任一項之具有血栓形成素受體激動作用 之醫藥組成物，其中Y1爲-NHCO-、-CONH-、-HCH2-、-NHCO-CH = CH·、或-NHSO20 6 .如1〜4中任一項之具有血栓形成素受體激動作用 之醫藥組成物，其中Y1爲_NHCO-。 7 .如i〜6中任一項之具有血栓形成素受體激動作用之 醫藥組成物，其中Z 1爲可有鹵素或低烷基取代之 1，4-亞苯基。 8. 如1〜7中任一項之具有血栓形成素受體激動作用 之醫藥組成物，其中R1爲Η或低烷基。 9. 如1〜8中任一項之具有血栓形成素受體激動作用 之醫藥組成物，其中R2爲Η、低烷基、鹵素、低烷 氧基、低烷硫基、或可有取代之胺基。 經濟部智慧財產局員工消費合作社印製 1 0.如1〜9中任一項之具有血栓形成素受體激動作用 之醫藥組成物，其中W 1爲如下式基 Ο
(式中 R13爲Η、低烷基、低烷氧基、低烷硫基、或 鹵素；R14及R15各自爲Η、或各可有一以上選自下述 -7- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 Α7 Β7 五、發明說明（6) (請先閱讀背面之注音？事項再填寫本頁) 取代基A之低院基、低儲基、低快基、環院基、芳 基、方院基、雜芳基、或雜芳院基；虛線表示鍵之有 或無存在； 取代基A:鹵素、鹵低烷基、可有取代之胺基、羧 基、低院硫基、低院基砂院基、或低院氧基）。 1 1 ·如1〜9中任一項之具有血栓形成素受體激動作用 之醫藥組成物，其中W 1爲如下式基 〇
(式中 R13爲Η、低烷基、低烷氧基、低烷硫基、 或鹵素；R26爲Η或低烷基；虛線表示鍵之有或無存 在）。 1 2 .如1〜1 1中任一項之具有血栓形成素受體激動作 用之醫藥組成物，其爲血小板生產調節劑。 1 3 · —種用途，以如1〜1 1中任一項之化合物製造血小 板生產調節劑。 經濟部智慧財產局員工消費合作社印製 1 4 · 一種調節哺乳動物血小板生產之方法，係對人等哺 乳動物投與治療有效量如1〜1 1中任一項之化合物。 15·—種如下式（II)化合物、其前藥、製藥容許鹽或這 些之媒合物 X2-Y2-Z2-W2 ( II ) [式中X2爲可有取代之5員雜芳基或可有取代之毗啶基； Υ’ 爲-NRACO-(CH2)0.2-、一 nrAC〇- (CHa> — V-、 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明（7 )-NRACO-CRe^CRD-% -V- (CH*) le.|^NRAC〇- (CH,) 〇-* 一，-乂一（CH 金）卜· - CONRA- (CHa)卜意-、-C〇NRA_ (CHa>0y'_ (CHJ 0-* - NRA - SOp (CH|) 〇_·-、 （ c H2) 0讎 * 一 SOa-NRA-（CH·) -、-Nr4- (CH*> ο-a -、一 NRA - c〇 - NRl, - NRA-C3 - NRA、一N«c (-sra) _NR A —% "* N R A C S N R A C O — % — N · C (—SRA) N R A C O — % — N R A —(CHt) t·* —NRA—CO —% — N R A C Ο N R A N( R b c O — % 本 一 N = C(-NRaRa)-NRaC0-(其中Ra各自爲H或低烷基；Rb 爲H或苯基；rC及rd各自爲h、鹵素、可有取代之 低垸基、可有取代之低烷氧基、可有取代之低烷硫 基、可有取代之低烯基、可有取代之低炔基、可有取 代之方基、可有取代之雜方基、可有取代之環院基、 可有取代之芳烷基、可有取代之雜芳烷基、可有取代 之非芳雜環基、或可有取代之胺基；V爲〇或s); Z2爲可有取代之亞苯基、可有取代之比陡二 基、可有取代之2,5 -噻吩二基、或可有取代之呋 喃二基； ^ W2爲如下式基 請 先 閱 讀 背 面 之 注 項 再 填 寫 本 頁 I I 訂 f
R1 •OR5 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 五、發明說明（
r:
.R3 Λ：
(請先閱讀背面之注意事項再填寫本頁) 目爲Η、鹵素、可 有取代之低烷基、可有取代之低烷氧基、可有取代之 低烷硫基、可有取代之低烯基、可有取代之低炔基、 可有取代之芳基、可有取代之雜芳基、可有取代之環 烷基、可有取代之芳烷基、可有取代之雜芳烷基、可 有取代之非芳雜環基、或可有取代之胺基； 經濟部智慧財產局員工消費合阼；ώ印製 R5，R6及R9各自爲Η、鹵素、可有取代之低烷 基、可有取代之低烯基、可有取代之低炔基、可有取 代之芳基、可有取代之雜芳基、可有取代之環烷基、 可有取代之芳院基、可有取代之雜芳院基、或可有取 代之非芳雜環基； Α2爲可有取代之芳基或可有取代之雜芳基； 虛線表示鍵之有或無存在） 但R2不爲咪唑基、三唑基、或四唑基]。 -10- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明（ 16.如15之化合物、其前藥、製藥容許鹽或這些之媒 合物，其中X2爲如下式基
或 R11 基、低烷氧羰基、鹵素、可有取代之胺羰基、可有取 代之雜芳基、或可有取代之芳基）。 17.如15或16之化合物、其前藥、製藥容許鹽或這 些之媒合物，其中X2爲如下式基
R ,20
氧羰基、鹵素、可有取代之胺羰基； R17、R18、R19、R2G、R2 1、R22、及 r23 各自爲 H、 可有一以上選自下述取代基8之低烷基、環烷基、可 有一以上選自下述取代基B之低烷氧基、低烷硫基、 鹵素、可有一以上選自下述取代基C之苯基、可有一 以上選自下述取代基C之雜芳基、或可有一以上選自 下述取代基C之非芳族雜環基； 取代基B:經基、低烷氧基、鹵素、羧基、低烷氧 羰基、芳氧羰基、可有取代之胺基、可有一以上選自 -11- 本紙張尺度適用中國國家標準（CNS)A4規格（2l〇xi97公爱） «1 ^1 ^1 ϋ .^1 ϋ J 丨、 a^i ϋ ϋ I (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 --- --B7_ 五、發明說明（1〇) 經濟部智慧財產局員工消費合作社印製 R1 %
下述取代基C之苯基、非芳族雜環基、及雜芳基； 取代基C:羥基、低烷基、鹵素、鹵低烷基、羧基 、低烷氧羰基、低烷氧基、可有取代之胺基、非芳族 雜環基、及雜芳基； R16 及 R17 可共形成-CH2-、-CH2CH2-、- h2ch2ch2- * 、-0CH2-、或-SCH2-。 1 8 .如1 5〜1 7中任一項之化合物、其前藥、製藥容許 鹽或這些之媒合物，其中Y2爲-NHCO-。 1 9 .如1 5〜1 8中任一項之化合物、其前藥、製藥容許 鹽或這些之媒合物，其中Z2爲可有鹵素或低烷基取 代之1，4-亞苯基。 2 0 ·如1 5〜1 9中任一項之化合物、其前藥、製藥容許 鹽或這些之媒合物，其中R1爲Η或低烷基。 2 1 ·如1 5〜2 0中任一項之化合物、其前藥、製藥容許 鹽或這些之媒合物，其中R2爲Η、低烷基、鹵素、 低烷氧基、低烷硫基、或可有取代之胺基。 2 2 .如1 5〜2 1中任一項之化合物、其前藥、製藥容許 鹽或這些之媒合物，其中W2爲如下式基
R1 〇 Ο R8
本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁)
1284639 A7 B7 11， 五、發明說明（ (式中 R1，R2，R3，R4，R5，R6，R7，R8 及 A2 同上 15; 但R2不爲咪唑基、三唑基、或四唑基）。 (請先閱讀背面之注意事項再填寫本頁) 2 3 .如1 5〜2 2中任一項之化合物、其前藥、製藥容許 鹽或這些之媒合物，其中W2爲如下式基 (式中 R13爲Η、低烷基、低烷氧基、低烷硫基、或 鹵素；R14及R15各自爲Η、或各可有一以上選自下述 取代基Α之低烷基、低烯基、低炔基、環烷基、芳 基、芳烷基、雜芳基、雜芳烷基、或非芳族雜環基； 取代基A:鹵素、鹵低院基、可有取代之胺基、竣 基、低院硫基、低院基砂院基、或低院氧基）。 24.如15〜22中任一項之化合物、其前藥、製藥容許 鹽或這些之媒合物，其中W2爲如下式基 Ο
OR26 經濟部智慧財產局員工消費合作社印製 (式中R 爲Η、低丨兀基、低院氧基、低院硫基、或 鹵素；R26爲Η或低烷基；虛線表示鍵之有或無存在）。 25.—種如下式（III)化合物、其前藥、製藥容許鹽或 這些之媒合物
本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (III) 1284639 A7 ^^------ B7______ 五、發明說明（12) [式中R10爲Η、可有取代之低烷基、羧基、低烷氧 羰基、鹵素、或可有取代之胺羰基； R17、 R18、 R19、 112()、及1121各自爲11、可有— 以上選自下述取代基Β之低烷基、環烷基、可有一以 上選自下述取代基Β之低烷氧基、低烷硫基、鹵素、 可有一以上選自下述取代基C之苯基、可有一以上選 自下述取代基C之雜芳基、或可有一以上選自下述取 代基C之非芳族雜環基； 取代基Β:羥基、烷氧基、鹵素、羧基、低烷氧羰 基、芳氧羰基、可有取代之胺基、可有一以上選自下 述取代基C之苯基、非芳族雜環基、及雜芳基； 取代基C:羥基、烷基、鹵素、鹵低烷基、羧基、 低烷氧羰基、低烷氧基、可有取代之胺基、非芳族雜 環基、及雜芳基； R16 及 R17 也可共形成-CH2-、-CH2CH2-、 -ch2ch2ch2-、-och2-、或-sch2-; R31及R32各自爲η、低烷基、鹵素、鹵低烷基、 低烷氧基、鹵低烷氧基、或羥基； (請先閱讀背面之注意事項再填寫本頁)
經濟部智慧財產局員工消費合作社印製
R24 ο 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 Α7 Β7 五、發明說明（13) (式中R13爲Η、低烷基、低烷氧基、低院硫基、或 鹵素； R14及R15各自爲Η、或各可有一以上選自下述取 代基Α之低烷基、低烯基、低炔基、環院基、芳基、 芳烷基、雜芳基、雜芳烷基、或非芳族雜環基； 取代基A:鹵素、鹵低院基、可有取代之肢基、竣 基、低烷硫基、低烷基矽烷基、或低院氧基； R24爲Η或低烷基； R25爲低烷基、可有取代之芳基、或可有取代之非 芳族雜環基； A3爲雑方基。 26.—種如下式（IV-A)化合物、其前藥、製藥容許鹽或 這些之媒合物 (請先閱讀背面之注意事項再填寫本頁) R30
經濟部智慧財產局員工消費合作社印製 [式中R27爲H、CM-3烷基、三氟甲基、或鹵素； R28、R29、及R3G各自爲Η、可有一以上選自下述 取代基Β之低烷基、環烷基、可有一以上選自下述取 代基Β之低烷氧基、低烷硫基、鹵素、可有一以上選 自下述取代基C之苯基、可有一以上選自下述取代基 C之雜芳基、或可有取代之非芳族雜環基； 取代基Β:羥基、低烷氧基、鹵素、羧基、低烷氧 -15- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） I284639 A7 B7 五、 發明說明（14) 幾基、芳氧羰基、可有取代之胺基、可有一以上選自 下述取代基C之苯基、非芳族雜環基、及雜芳基； 取代基c ··羥基、低烷基、鹵素、鹵低烷基、羧 基、低烷氧羰基、低烷氧基、可有取代之胺基、非芳 族雜環基、及雜芳基； R31及R32各自爲Η、低烷基、鹵素、鹵低烷基、 低烷氧基、鹵低烷氧基、或羥基； W4爲如下式基 〇 〇 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 (式中 R13爲Η、低烷基、低烷氧基、低烷硫基、或 鹵素； R14及R15各自爲Η、或各可有一以上選自下述取 代基Α之低烷基、低烯基、低炔基、環烷基、芳基、 芳烷基、雜芳基、雜芳烷基、或非芳族雜環基； 取代基A:鹵素、鹵低烷基、可有取代之胺基、羧 基、低烷硫基、低烷基矽烷基、或低烷氧基； R24爲Η或低院基。 2 7.—種如下式（IV-Β)化合物、其前藥、製藥容許鹽或 β些之媒合物 R R31
(1V-B) R32 [式中R28、R29、及R3G各自爲H、可有一以上選 -16· 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 —___B7__ 五、發明說明（15) 自下述取代基B之低烷基、環烷基、可有一以上選自 下述取代基B之烷氧基、烷硫基、鹵素、可有一以上 選自下述取代基C之苯基、可有一以上選自下述取代 基C之雜芳基、或可有取代之非芳族雜環基； 取代基B:羥基、低烷氧基、鹵素、羧基、低烷氧 羰基、芳氧羰基、可有取代之胺基、可有一以上選自 下述取代基C之苯基、非芳族雜環基、及雜芳基； 取代基C :羥基、低烷基、鹵素、鹵低烷基、羧 基、低烷氧羰基、低烷氧基、可有取代之胺基、非芳 族雜環基、及雜芳基； R31及R32各自爲Η、低烷基、鹵素、鹵低烷基、 低烷氧基、鹵低烷氧基、或羥基； W4爲如下式基
(式中 R13爲Η、低烷基、低烷氧基、低烷硫基、或 鹵素； R14及R15各自爲Η、或各可有一以上選自下述取 代基Α之低烷基、低烯基、低炔基、環烷基、芳基、 芳烷基、雜芳基、雜芳烷基、或非芳族雜環基； 取代基A:鹵素、鹵低烷基、可有取代之胺基、羧 基、低烷硫基、低烷基矽烷基、或低烷氧基； R24爲Η或低烷基）； Τ 爲-CH2-、-CH2CH2·、-CH2CH2CH2-、-OCH2-、或- -17- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁)
1284639 A7 B7 五、發明說明（16) SCH2-]。 2 8· —種醫藥組成物，內含如1 5〜2 7中任一項之化合 物爲有效成分。 2 9· 一種具有血栓形成素受體激動作用之醫藥組成 物，內含如1 5〜2 7中任一項之化合物爲有效成分。 3 0. 一種血小板生產調節劑，內含如1 5〜2 7中任一項 之化合物爲有效成分。 3 1· 一種用途，以如1 5〜2 7中任一項之化合物製造血 小板生產調節劑。 3 2· —種調節哺乳動物血小板生產之方法，係對人等 哺乳動物投與治療有效量如1 5〜2 7中任一項之化合 物。 本文中，「鹵素」可爲如氟、氯、溴及确，宜氟、 氯、溴。 本文中單獨或與其他詞倂用之「烷基」爲C1〜15直 或分枝一價烴基，例如甲基、乙基、正丙基、異丙基、 正丁基、異丁基、第二丁基、第三丁基、正戊基、異 戊基、新戊基、正己基、異己基、正庚基、正辛基、 正壬基、正癸基、正十一基、正十二基、正十三基、 正十四基、正十五基等。宜C1〜10烷基，更宜Ci〜6院 基。 本文中單獨或與其他詞倂用之「低烷基」爲c 1〜8 之直或分枝一價烴基，例如甲基、乙基、正丙基、異丙 基、正丁基、異丁基、第二丁基、第三丁基、正戊 -18 - 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ------!# (請先閱讀背面之注意事項再填寫本頁) 裝------- 訂---------零 經濟部智慧財產局員工消費合作社印製 1284639 A7 ____ B7 五、發明說明（17 ) 基、異戊基、新戊基、正已基、異己基、正庚基、正 辛基等，宜<^〜6烷基，更宜（^〜3烷基。 本文中單獨或與其他詞倂用之「C 1〜3伸烷基」可 爲如亞甲基、伸乙基及伸丙基。 本文中單獨或與其他詞倂用之「環烷」爲c3〜8之單 環之環烷，例如環丙烷、環丁烷、環戊烷、環已烷、環 庚烷、環辛烷。尤宜C3〜6環烷。 本文中單獨或與其他詞倂用之「環烷基」爲c3〜8之 單環之環烷基。例如環丙基、環丁基、環戊基、環已 基、環庚基、環辛基。尤宜C3〜6環烷基。 本文中，「低烯基」爲C2〜8，有1或2個以上之雙鍵 結合之直或分枝之一價烴基，例如乙烯基、烯丙基、1-丙烯基、2 -丙烯基、種種之丁烯基異性體等。宜C 2〜6 嫌基，更宜C2〜4嫌基。 本文中，「低炔基」爲C2〜8,有1〜2個以上之三鍵結 合之直或分枝之一價烴基，例如乙炔基、1 -丙炔基、 2 -丙炔基、1 -丙炔基' 2 -丙炔基、丁炔基、異戊炔 基、種種丁炔基異性體等。宜C2〜6炔基，更宜C2〜4炔 經 濟 部 智 慧 財 產 局 員 工 消 費 合 作 社 印 製 基。 本文中單獨或與其他詞倂用之「芳基」爲單環狀或 稠合環狀芳族烴基，例如苯基、1_萘基、2_萘基、蒽基 本文中，「芳烷基」爲前述「低烷基」之前述「芳 基」1或2以上取代，這些可能全位置取代之，例如苄 -19-
A7 B7 1284639 五、發明說明（18) 基、苯乙基（例如2-苯乙基等）、苯丙基（例如3-苯丙基 等）、萘甲基（例如1-萘甲基、2-萘甲基等）、蒽甲基（例 如9-蒽甲基等）等，宜苄基、苯乙基。 裝--------訂--------- 本文中單獨或與其他詞倂用之「非芳族雜環基」爲 環內有任意選自0，S或N，一個以上之5〜7員非芳族 環或彼等2個以上稠合環。例如吡咯啶基（例如丨-吡咯 啶基、2-吡咯啶基）、吡咯啉基（例如3-吡咯啉基）、咪 唑啶基（例如2-咪唑啶基）、咪唑啉基（例如吡咪唑啉 基）、吡唑啶基（例如1-吡唑啶基、2-吡唑啶基）、吡唑 啉基（例如吡唑啉基）、哌啶基（例如N-哌啶基、2-哌啶 基）、哌哄基（例如1 -哌畊基）、吲哚啉基（例如1 -吲哚 啉基）、異吲哚啉（例如異吲哚啉）、嗎啉基（例如N —嗎 啉基、3_嗎啉基）、四氫呋喃基、四氫吡喃基等。 R17、R 18、R 19、R 20、R 21、R 22、R 23、R 28、 R29、及R3G中「非芳族雜環基」宜N-嗎啉基、N-哌 阱基、N-吡咯啶基、四氫呋喃基、四氫吡喃基等。 取代基B中「非芳族雜環基」宜N-嗎啉基、N-哌哄 基、N-哌啶基、四氫呋喃基、四氫吡喃基等。 經濟部智慧財產局員工消費合作社印製 取代基C中「非芳族雜環基」宜N-嗎啉基、N-哌哄 基、N -哌啶基、N -吡咯啶基、四氫呋喃基、四氫吡喃 基等。 本文中單獨或與其他詞倂用之「雜芳基」爲環內有 任意選自〇，S或N —個以上之5〜6員之芳香環，此可 在前述「環烷基」，前述「芳基」，前述「非芳族雜環 -20- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 19 五、發明說明（ 基」，或其他「雜芳基」之任何可能之位置縮合。若雜 芳基爲單環或稠環時，可在任何可能之位置縮合，例如 、吡咯基（例如、1-吡咯基、2-吡咯基、3-吡咯基）、呋 喃基（例如、2-呋喃基、3-呋喃基）、噻吩基（例如、2· 噻吩基、3-噻吩基）、咪唑基（例如、2-咪唑基、4-咪唑 基）、吡唑基（例如、1 -吡唑基、3 -吡唑基）、異噻唑基 (例如、3-異噻唑基）、異噚唑基（例如、3_異噚唑基）、 噚唑基（例如2-噚唑基）、噻唑基（例如2-噻唑基）、吡 啶基（例如2-吡啶基、3-吡啶基、4-吡啶基）、吡哄基 (例如2-吡哄基）、嘧啶基（例如2-嘧啶基、4-嘧啶基） 、嗒畊基（例如3 -嗒畊基）、四唑基（例如1 η -四唑基）、 噚二唑基（例如1，3，4 ·噚二唑基）、噻二唑基（例如丨，3， 4 -噻二唑基）、吲畊基（例如2 -吲哄基、6 -吲哄基）、異 吲哚基（例如2_異吲哚基）、吲哚基（例如丨_吲哚基、2_ 吲哚基、3-吲哚基）、吲唑基（例如3-吲唑基）、嘌啥基 (例如8-嘌呤基、喹哄基（例如2-喹哄基）、異喹啉基 (例如3-異喹啉基）、喹啉基（例如2_喹啉基、5-喹啉 基）、呔哄基（例如1 -呔畊基）、Ρ奈啶基（例如2 -喑啶基） 、喹喏醛基、喹唑啉基（例如、2-喹唑啉基）、哮哈基 (例如3-哮呤基）、喋啶基（例如2-喋啶基）、咔唑基（例 如2-咔唑基、4-咔唑基）、啡啶基（例如2-啡啶基、3-啡啶基）、吖啶基（例如1-吖啶基、2-吖啶基）、二苯并 呋喃基（例如1-二苯并呋喃基' 2-二苯幷呋喃基）、苯 并咪唑基（例如2-苯并咪唑基）、苯并異噚唑基（例如3 -----------丨％ (請先閱讀背面之注意事項再填寫本頁) 訂---------費 經濟部智慧財產局員工消費合作社印製 -21- 1284639 A7 B7 五、發明說明（2G) (請先閱讀背面之注咅？事項再填寫本頁) 苯并異噚唑基）、苯并噚唑基（例如2-苯并噚唑基）、苯 并噚二唑基（例如4-苯并噚二唑基）、苯并異噻唑基（例 如3-苯并異噻唑基）、苯并噻唑基（例如2-苯并噻唑基） 、苯并呋喃基（例如3-苯并呋喃基）、苯并噻吩基（例如 2-苯并噻吩基）、4,5-二氫萘并[1，2-(1]噻唑基、411-色烯 并[4,3-(1]噻唑、411-硫色烯并[4,3-(1]噻唑、4,5-二氫噻 唑并[5,4-c]喹啉基、8H-茚并[l，2-d]噻唑基、5,6-二氫-4H-3-噻-l-ΡΥ-苯并[e]葜基等。 X1中「雜芳基」宜噻唑基、異噚唑基、噻吩基、咔 唑基、苯并噻唑基、吡啶基、吡唑基等，尤宜噻唑基、 吡啶基等。 R1、R 2、R 3、R4、R 7及R8中「雜芳基」宜吡啶 基、噻唑基、苯并噻唑基等。 R1G及R11中「雜芳基」宜吡啶基、噻吩基、呋喃 基、嘧啶基、咪唑基、噻唑基、噚唑基、三唑基等。 A，1、A2及A3中「雜芳基」宜咪唑基、三唑基、四 唑基、吡啶基、嘧啶基等。 經濟部智慧財產局員工消費合作社印製 R17、R 18、R 19、R 20、R 21、R 22、R 23、R 28、 R29及R3G中「雜芳基」宜吡啶基、噻唑基、呋喃 基、嘧啶基、咪唑基、噻唑基、噚唑基、三唑基等。 取代基B中「雜芳基」宜吡啶基、吡唑基、嘧啶 基、咪唑基、噚唑基、噻唑基、呋喃基、噻吩基等。 取代基C中「雜芳基」宜吡啶基、吡唑基、咪唑基 -22- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐1 1284639 A7 B7 五、發明說明（21 ) 本文中「5員雜環基」爲環內有任意選自〇,8或1 一個以上之5員芳族環。例如噻吩基、呋喃基、吡咯 基、咪唑基、吡唑基、異噻唑基、異噚唑基、噻唑基 、噚唑基、1，2,3-三唑基、1，2,4·三唑基、l，2,4-噻二 口坐基、1，3,4-_二卩坐基、ι，2,4 -嘴二D坐基、ι，3,4 -噚二 唑基等。尤宜噻唑基。 本文中「雜芳烷基」爲在前述「低烷基」之任一位 置有前述「雜芳基」1〜2以上取代者，這些可能全位置 取代之。例如噻吩甲基（例如2 -噻吩甲基）、噻吩乙基（ 例如2 -(噻吩-2 -基）乙基）、呋喃甲基（例如2 -呋喃甲基） 、呋喃乙基（例如2-(呋喃-2-基）乙基）、吡咯甲基（例如 2- 吡咯甲基）、吡咯乙基（例如2-(吡咯-2-基）乙基）、咪 唑甲基（例如2-咪唑甲基、4-咪唑甲基）、咪唑乙基（例 如2 -(咪U坐-2 -基）乙基）、吡P坐甲基（例如3 -吡U坐甲基）、 吡唑乙基（例如2-(吡唑-3-基）乙基）、噻唑甲基（例如2-噻唑甲基）、噻唑乙基（例如2 -(噻唑-2 -基）乙基）、異噻 唑甲基（例如3-異噻唑甲基）、異噚唑甲基（例如3 _異噚 唑甲基）、噚唑甲基（例如2-噚唑甲基）、噚唑乙基（例 如2-(噚唑-2-基）乙基）、吡啶甲基（例如2-吡啶甲基、 3- 吡啶甲基、4-吡啶甲基）、吡啶乙基（例如2_吡啶乙 基）等。
Ri、R2、R3、R4、R7及r8中「雜芳院基」可爲2-噻吩甲基，2-呋喃甲基等。 本文中「亞苯基」爲2價苯基，如1,2 -亞苯基、1,3- -23- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注音？事項再填寫本頁) ·11!111 訂 — I! — — — — ·
經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明（22) 亞苯基、1，4-亞苯基。宜ι，4-亞苯基。 本文中「單環亞雜芳基」爲前述「雜芳基」中單環 之雜芳基之2價基。例如噻吩二基、呋喃二基、壯陡 一基等。g羊g之，可爲2,5 -嚷吩二基、2,5 -咲喃二基、 2,5-l|tD定一基、2,5_噻 Π坐二基、2,5_(1，3,4_ 噻二 Π坐）二基 、2，5 -吡啶二基、2，5 -吡唑二基、3，6 -嗒畊二基、2，5 -(4H-吡喃）二基等。尤宜2,5-噻吩二基、2,5-呋喃二基 、2，5 -吡啶二基。 本文中「單環非芳族雜環二基」爲前述「非芳族雜 環基」中單環之非芳族雜環基之2價基。例如吡咯啶 二基、哌啶二基、吡畊二基等。 本文中「單環環烷二基」爲前述「環烷」中單環之環 烷之2價基。例如1，4-環戊二基、1,4-環己二基等。 本文中「丨兀氧基」可爲如甲氧基、乙氧基、正丙氧 基、異丙氧基、正丁氧基、異丁氧基、第二丁氧基、 第三丁氧基、正戊氧基、正己氧基、正庚氧基、正辛 氧基、正壬氧基、正癸氧基等。宜甲氧基、乙氧基、 正丙氧基、異丙氧基、正丁氧基。 本文中「低烷氧基」可爲如甲氧基、乙氧基、正丙 氧基、異丙氧基、正丁氧基、異丁氧基、第二丁氧基 、第三丁氧基等。宜甲氧基、乙氧基、正丙氧基、異 丙氧基、正丁氧基。 本文中「低烷硫基」可爲如甲硫基、乙硫基等。 本文中「低烷氧羰基」可爲如甲氧羰基、乙氧羰 -24- (請先閱讀背面之注意事項再填寫本頁) -ϋ I · -裝--------訂---------
本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639
五、發明說明（23 ) 基、正丙氧羰基、異丙氧羰基、正丁氧羰基、第三丁 氧羰基、正戊氧羰基等。 本文中「芳氧羰基」可爲如苯氧羰基、1-萘氧羰基 、2-萘氧羰基等。 本文中單獨或與其他詞倂用之「醯基」爲烷基部分 爲前述「低烷基」之烷羰基或芳基部分之前述「芳基 」爲「芳羰基」，例如乙醯基、丙醯基、丁醯基、苄醯 基等。「低烷基」及「芳基」各也可有後述取代基。 本文中單獨或與其他詞倂用之「鹵低烷基」爲有前 述鹵素1〜8，宜1〜5個取代之前述「低烷基」。例如 三氟甲基、三氯甲基、二氟乙基、三氟乙基、二氯乙 基、三氯乙基等，宜三氟甲基。 本文中「鹵低烷氧基」爲如三氟甲氧基、三氯甲氧 基、二氟乙氧基、三氟乙氧基、二氯乙氧基、三氯乙 氧基等，宜三氟甲氧基。 本文中「醯氧基」爲如乙醯氧基、丙醯氧基、苄醯 氧基等。 本文中「低院砂院基」可爲如二乙基砂院基、第三 丁基二甲基矽烷基。 本文中單獨或與其他詞倂用之「可有取代之胺基」 爲可有前述「低烷基」、前述「芳基」、前述「芳烷 基」、前述「雜芳基」、前述「雜芳院基」、或前述 「醯基」1或2個取代之胺基，例如胺基、甲胺基、二 甲胺基、乙基甲胺基、二乙胺基、乙基甲胺基、苄胺 -25- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐1 '""
1284639
發明說明（ 經 濟 部 智 慧 財 產 局 員 工 消 費 合 作 社 印 製 基、乙醯胺基、苄醯胺基等。宜胺基、甲胺基、二甲 胺基、乙基甲胺基、二乙胺基、乙醯胺基。 本文中「可有取代之胺羰基」爲可如胺羰基、甲胺 鑛基、二甲胺羰基、乙基甲胺羰基、二乙胺羰基等。 宜胺鑛基、甲胺羰基、二甲胺羰基。 本文中「可有取代之脲基」爲可有前述「低烷基」 、則述「方基」、前述「芳烷基」、前述「雜芳基」 、則述「雜芳烷基」或前述「醯基」1或2個取代之 脲基。 本文中「可有取代之低烷基」之取代基可爲環烷 基、低嫌基、低亞烷基、羥基、低烷氧基、氫硫基、 低烷硫基、鹵素、硝基、氰基、羧基、低烷氧羰基、 齒低院基、鹵低烷氧基、可有取代之胺基、可有取代 之胺羰基、醯基、醯氧基、可有取代之非芳族雜環基 、芳氧基（例如苯氧基）、芳烷氧基（例如苄氧基）、低烷 磺醯基、胍基、偶氮基、可有取代之脲基、=N_〇_ (醯 基）# 追些取代基，皆在可能之位置有1個以上取 Rc及Rd中「可有取代之低烷基」之取代基可爲鹵 素、鹵低烷基等。 「可有取代之低烷基」之取代基可爲羥基、竣基、齒 素、烷氧基、烷硫基、烷基矽烷基、可有取代之胺基 、氰基、醯基等。 -26- ^紙張尺度適用中國國家標準（CNS)A4規格（21〇 X 297公爱 f請先閱讀背面之注音W事項再填寫本頁)
訂--------- 零. 1284639 經濟部智慧財產局員工消費合作社印製 A7 ------------B7 ____ 五、發明說明（25 ) R1G、R 11、R 16在「可有取代之低烷基」之取代基 宜低院氧碳基、鹵素。 R12中「可有取代之低烷基」之取代基可爲環烷基 、低烯基、低亞烷基等。 本文中「可有取代之低烷氧基」及「可有取代之低 院硫基」之取代基可爲環烷基、低烯基、低亞烷基、 經基、低烷氧基、氫硫基、低烷硫基、鹵素、硝基、 氰基、竣基、低烷氧羰基、鹵低烷基、鹵低烷氧基、 可有取代之胺基、可有取代之胺羰基、醯基、醯氧 基、可有取代之非芳族雜環基、芳氧基（例如苯氧基） 、芳垸氧基（例如苄氧基）、低烷磺醯基、胍基、偶氮 基、可有取代之脲基、=N-0-(醯基）等。這些取代基 皆在可能之位置有1個以上取代。尤宜鹵素等。 本文中「可有取代之低烯基」及「可有取代之低炔 基」之取代基可爲環烷基、低亞烷基、羥基、低烷氧 基、氫硫基、低院硫基、鹵素、硝基、氰基、殘基、 低院氧滕基、鹵低垸基、鹵低院氧基、可有取代之胺 基、可有取代之胺羰基、醯基、醯氧基、可有取代之 非方族雜環基、芳基、芳氧基（例如苯氧基）、芳院基 /芳院氧基（例如苄氧基）、低烷磺醯基、胍基、偶氮 基、可有取代之脲基等。這些取代基，皆在可能之位置 有1個以上取代。 本文中「可有取代之亞苯基」、「可有取代之單環 亞雜芳基」、「可有取代之2,5-吡啶二基」、「可有 -27- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） | ^1 ϋ ϋ I I ϋ I 一-ο, 1 n ϋ ϋ n ϋ I (請先閱讀背面之注意事項1再填寫本頁) 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（26) 取代之2,5 -噻吩二基」、「可有取代之2,5_呋喃二 基」、「可有取代之單環非芳族雜環二基」、「可有 取代之單環環烷二基」、「可有取代之芳基」、「可 有取代之苯基」、「可有取代之雜芳基」、「可有取 代之5員雜芳基」、「可有取代之吡啶基」、「可有 取代之非芳族雜環基」、「可有取代之環烷基」、 「可有取代之芳烷基」及「可有取代之雜芳烷基」中 取代基可爲烷基、環烷基、低烯基、低炔基、羥基、 烷氧基、芳烷氧基、氫硫基、低烷硫基、鹵素、硝基 、氰基、羧基、低烷氧羰基、芳氧羰基、鹵低烷基、 鹵低烷氧基、可有取代之胺基、可有取代之胺羰基、 醯基、醯氧基、可有取代之芳基（取代基可爲如鹵素、 羧基、烷基、烷氧基等）、可有取代之雜芳基（取代基 可爲如鹵素、羧基、烷基、烷氧基等）、可有取代之非 芳族雜環基、可有取代之芳烷基、低烷磺醯基、胍基 、偶氮基、-N = N-(可有取代之苯基）或可有取代之 基等。這些取代基，皆在可能之位置有1個以上取代。 「可有取代之亞苯基」、「可有取代之單環亞雜芳 基」、「可有取代之2,5 -吡啶二基」、「可有取代之 2,5 -噻吩二基」、「可有取代之2,5 -呋喃二基」、 「可有取代之單環非芳族雜環二基」及「可有取代之 單環環烷二基」中取代基宜鹵素、硝基、氰基、低烷 基、低烷氧基等、宜非取代者。 X1中「可有取代之芳基」及「可有取代之芳烷基」 -28- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ~裝--------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 27 五、發明說明（ 請 先 閱 讀 背 之 注 中取代基可爲低烷基、羥基低烷基、羥基、低烷氧基 、低烷硫基、鹵素、硝基、氰基、羧基、鹵低烷基、 鹵低烷氧基、芳烷氧基、可有取代之胺基、可有取代 之胺羰基、芳基、雜芳基、非芳族雜環基、-N = N-(苯 基）等。宜取代基可爲如低烷基、低烷氧基、低烷硫基 、鹵素、鹵低烷基、芳烷氧基、-N = N-(苯基）、伸烷二 氧基等 ° I 訂 X1中「可有取代之芳基」可爲如苯基、3_甲苯基、 4-甲苯基、3，4-二甲苯基、4-乙苯基、4-第三丁苯基、 4-正丁苯基、4-正已苯基、4-正辛苯基、3,5-二第三丁 基-4-羥苯基、4-乙氧苯基、4-氟苯基、3,5-二氯苯基 、4 -碘苯基、4 -三氟甲苯基、4 -甲硫苯基、4 -苯氧甲苯 基、偶氮苯-4-基、苯并二噚茂基（例如ι，3 -苯并二噚 茂基）等。 經濟部智慧財產局員工消費合作社印製 R1Q及Rii中「可有取代之芳基」之取代基可爲鹵素 、可有取代之烷基、環烷基、低烯基、低炔基、羥基 、烷氧基、氫硫基、低烷硫基、硝基、氰基、羧基、 低院氧幾基、鹵低院基、鹵低院氧基、可有取代之胺 基、可有取代之胺羰基、醯基、甲醯基、醯氧基、可 有取代之芳基、可有取代之雜芳基（例如吡啶基、咪唑 基）、非芳族雜環基（例如嗎咐基、哌哄基）、芳院基等 。宜可有1以上取代基B之烷基、環烷基、可有丨以 上取代基B之烷氧基、烷硫基、鹵素、可有丨以上取 代基C之苯基、可有丨以上取代基c之雜芳基、或可 -29- 1284639
有1以上取代基C之非芳族雜環基等（取代基B ··羥 基、烷氧基、鹵素、羧基、低烷氧羰基、芳氧羰基、 可有取代之胺基、可有1以上取代基C之苯基、非芳 族雜環基及雜芳基、 取代基C ··羥基、烷基、鹵素、鹵低烷基、羧基、 低烷氧羰基、烷氧基、可有取代之胺基、非芳族雜 環、及雜芳基）。又該芳基可與C5_7環烷環（例如環戊 院、環已院等）或非芳族雜環基（例如四氫呋喃基、1,3 一噚茂基、1，4-二噚茂基、吡咯啶基等）稠合形成印 烷、I，2,3,4·四氫萘、丨，2,3,仁四氫噻啉、2,3_二氫苯并 Π，4]二噚英、苯幷π，3]二噚茂、2,3_二氫苯并呋喃、 2,3-二氫-1Η-吲哚。 X1中「可有取代之雜芳基」及「可有取代之雜芳烷 基」之取代基，可有取代之低烷基、低烯基（例如=c η _ 經濟部智慧財產局員工消費合作社印製 C Η。、低炔基、羥基、低烷氧基、氫硫基、低烷硫基 、鹵素、硝基、氰基、羧基、低烷氧羰基、鹵低烷基 、鹵低烷氧基、可有取代之胺基、可有取代之胺羰基 、醯基（例如鹵素、硝基、氰基等可有取代之芳氧羰基 等）、醯氧基、可有取代之芳基、可有取代之雜芳基 (例如2 -吡D定基、3 - Ift D定基、4 -吡Π定基、3 -藤吩基、5 » 甲基吡啶-2-基、3 -喹啉基、5 -氯噻吩-2-基、5 -溴嚷吩 2-基）、非芳族雜環基、芳烷基、(醯基）等。宜 可有取代之低院基、低嫌基、低院氧幾基、可有取代 之苯基、雜芳基、=N-〇-(醯基）等。 -30- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（） 雜原子可爲N時，該N爲烷基，氧等之取代。 X2中「可有取代之5員雜芳基」之取代基，可有取 代基低院基、低燃基（例如=C Η - C Η 3 )、低快基、經基、 低烷氧基、氫硫基、低烷硫基、鹵素、硝基、氰基、 羧基、低烷氧羰基、鹵低烷基、鹵低烷氧基、可有取 代之胺基、可有取代之胺羰基、醯基（例如鹵素、硝基 、氰基等可有取代之芳氧羰基等）、醯氧基、可有取代 之芳基、可有取代之雜芳基（例如2-吡啶基、3-吡啶基 、4-吡啶基、2-呋喃基、3-呋喃基、2 -噻吩基、3 -噻吩 基、5 -甲基吡啶-2 -基、吲哚-3 -基、3 -喹啉基、5 -氯嗤 吩-2-基、5 -溴噻吩-2-基）、非芳族雜環基、芳院基、 = Ν·0-(醯基）等。 宜可有1以上取代基Β之烷基、環烷基、可有1以 上取代基Β之烷氧基、烷硫基、鹵素、可有i以上取 代基C之苯基、可有1以上取代基C之雜芳基、或可 有1以上取代基C之非芳族雜環基等（取代基B:羥 基、烷氧基、鹵素、羧基、低烷氧羰基、芳氧羰基、 可有取代之胺基、可有1以上取代基C之苯基、非芳 族雜環基及雜芳基、 取代基C:羥基、烷基、鹵素、鹵低烷基、羧基、 低烷氧羰基、烷氧基、可有取代之胺基、非芳族雜環 及雜芳基）。 R1Q及R11中「可有取代之雜芳基」之取代基可爲_ 素、可有取代之烷基、環烷基、低烯基、低炔基、羥 -31- 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） (請先閱讀背面之注意事填寫本頁) ---^--------訂-------- 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（ R及R11中「可有取代之雜芳基」之取代基可爲處 素、可有取代之烷基、環烷基、低烯基、低炔基、芦 基、烷氧基、氫硫基、低烷硫基、硝基、氰基、羧工 基、低烷氧羰基、鹵低烷基、鹵低烷氧基、可有=代 之胺基、可有取代之胺羰基、醯基、甲醯基、_氧 基、可有取代之芳基、可有取代之雜芳基(例如壯啶 基、咪哩基）、非芳族雜環基（例如嗎啉基、哌哄基）、 芳院基等。宜可有1以上取代基B之烷基、環院基、 可有1以上取代基B之烷氧基、烷硫基、_素、可有 1以上取代基c之苯基、可有1以上取代基c之雜芳 基、或可有1以上取代基C之非芳族雜環基等（取代 基B ··羥基、烷氧基、鹵素、羧基、低烷氧羰基、芳 氧幾基、可有取代之胺基、可有丨以上取代基C之苯 基、非芳族雜環基及雜芳基、 取代基C:羥基、烷基、鹵素、鹵低烷基、羧基、 低烷氧羰基、烷氧基、可有取代之胺基、非芳族雜環 及雜芳基）。 本文中，（a 表示α有冷〜7個，例如（CRcRD) 0_ 2 表示（CRcRd)有 〇〜2 個，（CH2) 〇_2 表示（Ch2) 有〇〜2個，（CH2) μ表示（CH2)有1〜5個。 本文中「血小板產生調節劑」包括血小板減少症 (骨髓移植後之血小板減少、化學療法後之血小板減 少、再生不良性貧血、骨髓異形成症候群、難治性突 發性血小板減少性紫斑病等後天性血小板減少症、血 -32- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐）
1284639 A7 B7 31 五、發明說明（ 請 先 閱 讀 背 面 之 注 意 事 項 再 填 窝 本 頁 栓形成素缺損症等先天性血小板減少症）等伴隨血小 板數異常之血症疾病之病態之藥劑。例如若因投與抗 癌劑而血小板數減少時可當作治療藥，若因投與抗癌劑 而預測血小板數減少時可當作預防藥。 本文中「血小板產生調節劑」包括：1)增加因投與抗 癌劑等而減少之血小板數，2)維持因投與抗癌劑等而可 能之血小板數減少，3)降低因投與抗癌劑等所致之血小 板數減少程度。 圖面之簡單說明 第1圖：測定由於本發明化合物而從人骨髓細胞形成 之巨核血球集落數，以表示本發明化合物之巨核血球前 驅細胞之增殖分化促進作用。 第2圖：橫軸爲本發明化之濃度，縱軸爲作爲細胞增 殖指標之吸光度，表示由於本發明化合物而表現人TPO 受體之人TPO依存性細胞株之細胞增殖。白圓爲由於 人TPO之反應，黑圓爲由於化合物（B-1 )之反應。 經濟部智慧財產局員工消費合作社印製 第3圖：橫軸爲本發明化之濃度，縱軸爲作爲細胞增 殖指標之吸光度，表示由於本發明化合物而表現小白鼠 TPO受體之小白鼠TPO依存性細胞株之細胞增殖。三 角爲由於小白鼠TPO之反應，黑圓爲由於化合物（B-1 )之反應。 實施發明之最佳形態 本發明化合物（I)可依如下A法及B法，及其類似方 法合成。 -33- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 ____B7 32五、發明說明（） (A法）
經濟部智慧財產局員工消費合作社印製 (式中R1、R2、R3及X1同前） (第1工程） 本工程爲將4 -甲醯基或4 -醯基取代苯甲酸衍生物之 殘酸以RE保護之工程。因在第3工程須將2個竣酸保 護基選擇脫保護，故與RF之組合很重要。例如爲如 甲基、乙基等在鹼性條件可脫保護之保護基時，RE須爲 在非鹼性條件可脫保護之保護基，例如烯丙基（以Pd (〇 )錯合物脫保護）、第三丁基、對甲氧苄基、三 苯甲基、二苯甲基（在酸性條件脫保護）、三甲基矽 烷基乙基、三甲基矽烷基乙氧基甲基、第三丁基二甲 基矽烷基（以氟離子脫保護）等。 酯化之條件可在適當鹼之存在下，用與相當鹵化物反 應之方法。也可以醇衍生物爲原料之縮合反應等來合 -34- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁)
1284639 A7 B7 33 五、發明說明（ 成。 (第2工程） 請 先 閱 背 面 之 注 意 事 項* 本工程爲將醛或酮轉換爲烯之工程。可依Wittig反 應、Horner-Emmons反應等用磷化物之反應，或施行 Knoevenagel反應等脫水縮合反應來合成。 (第3工程） 本工程爲施行R E之脫保護之工程。依P r 〇 t e c t i v e Groups in Organic Synthesis, Theodora W Green(John Wiley & Sons)等之方法將保護基RE以適當反應條件 脫保護。 (第4工程） I 訂 本工程爲將羧酸衍生物（VII )與胺衍生物（X1· 經濟部智慧財產局員工消費合作社印製 N Η 2 )依活性酯法、醯氯法、混合酐法等反應，得醯胺 衍生物（VIII )之工程。本工程乃在四氫呋喃、二噚 烷、二氯甲烷、甲苯、苯等溶劑中施行。活性酯法可 以1 -羥基苯并三唑、羥基丁二醯亞胺、二甲胺基吡啶 等，及二環已基碳化二亞胺，1-乙基- 3-(3-二甲胺丙基） 碳化二亞胺鹽酸鹽爲縮合劑來施行。醯氯法乃以亞磺 醯氯、草醯氯爲試劑，將自由之羧酸先作成醯氯來施 行。混合酐法乃令羧酸與氯甲酸乙酯、氯甲酸異丁酯 等反應而作成混合酐來施行。必要時可用三乙胺、吡 B定等鹼。 (第5工程） 本工程爲施行RF2脫保護之工程。依Protective 35- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公爱） 1284639 A7 B7 五、發明說明（ 34
Groups in Organic Synthesis, Theodora W Green(John W i 1 e y & S ο n s )等之方法將保護基R F以適當反應條件 脫保護。 (第6工程） 本工程爲將羧酸衍生物（IX)與胺衍生物（X1-NH2 )依活性酯法、醯氯法、混合酐法等反應，得醯胺 衍生物（I - A )之工程。本工程乃在四氫呋喃、二噚 烷、二氯甲烷、甲苯、苯等溶劑中施行。活性酯法可 以1 -羥基苯并三唑、羥基丁二醯亞胺、二甲胺基吡啶 等，及二環已基碳化二亞胺，1-乙基- 3-(3-二甲胺丙基） 碳化二亞胺鹽酸鹽爲縮合劑來施行。醯氯法乃以亞磺 醯氯、草醯氯爲試劑，將自由之羧酸先作成醯氯來施 行。混合酐法乃令羧酸與氯甲酸乙酯、氯甲酸異丁酯 等反應而作成混合酐來施行。必要時可用三乙胺、吡 陡等驗。 (B法） 本法爲合成A法中化合物（VIII)之另法。 第2工程 請 先 閱 讀 背 面 之 注 意 事 %!裝 頁I I I I I I I訂 經濟部智慧財產局員工消費合作社印製
(第1工程） 本工程爲仿A法第4工程合成羧醯胺衍生物（XI ) 之工程。 -36- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公爱） 1284639 A7 B7 五、發明說明（ 35 (第2工程） 本工程爲仿A法第2工程將醛衍生物（XI )轉換爲 烯衍生物（XII )之工程。化合物（XII )可仿A法第 5及6工程反應而轉換成化合物（I-a )。 依合成W1爲-N(-烷基）-CO-,Ζ1爲可有取代之吖 唑等之如下式化合物 Z1—W1 CTY (W1及Z1同前，Aik爲低烷基）時之烷化條件而有時 得如下式化合物 Aik -----! ——％ (請先閱讀背面之注意事項再填寫本頁) 裝------
(W1 當式（I) 、（ II)及（III)內虛線爲有鍵存在時， 包括順體、反體及其混合物。例如W 1爲醯胺型化合 物時，可有如下順體及反體。當W1爲醯胺型以外之取 代基時也同 訂！-----青 經濟部智慧財產局員工消費合作社印製 R1 Ο xi_yi_zi^^n-r3 R1 X1 - Y1—Z1\ 及 -37- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐）
R4 R2 Ν' R3 1284639 A7 五、 發明說明（ 36 經濟部智慧財產局員工消費合作社印製 (式中 Rl、R2、R3' R4、χι、γΐ 及 ζι 同前） 本文中「媒合物」包括如與有機溶劑之媒合物、水 合物等。 「本發明化合物」包括製藥容許鹽或其水合物。例 如與鹼金屬（如鋰、鈉、鉀等）、鹼土金屬（如鎂、鈣 等）、銨、有機鹼及胺基酸之鹽；或與無機酸（鹽酸、 氫溴酸、磷酸、硫酸等），及有機酸（乙酸、檸檬酸、 馬來酸、晶馬酸、苯磺酸、對甲苯磺酸等）之鹽。這 些鹽可依常法形成。形成水合物時，可與任何數之水分 子配位。 前藥爲具有化學上或代謝上可分解之基之本發明化 合物之衍生物，在加溶劑分解或生理條件下體內形成藥 學活性之本發明化合物。適當前藥衍生物之選擇及製 造方法記載於如 Design of Prodrugs，Elsevier, Amsterdam 1 9 8 5.本發明化合物有羧基時，可例示元本之 酸性化合物與適當醇反應而得之酯衍生物，或元本之酸 性化合物與適當胺反應而得之醯胺衍生物等前藥。作 爲前藥適宜之酯衍生物有例如、甲酯、乙酯、正丙 酯、異丙酯、正丁酯、異丁酯、第三丁酯、嗎啉基乙 酯等）、芳烷酯衍生物（例如、苄酯、苯乙酯、二苯甲 酯等）。醯胺衍生物、烷基醯胺衍生物（N-甲醯胺、N-乙醯胺、N-(正丙基）醯胺、N-異丙醯胺、N-(正丁基） 醯胺、N-異丁醯胺、N-(第三丁基）醯胺等）、芳烷醯胺 衍生物（例如、N-苄醯胺、N-苯乙醯胺、二苯甲醯胺等） -38- ΐ紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 請 先 閱 讀 背 面 之 注 意 事 I裝 麥 頁I I I I I I I 訂 1284639 A7 B7 五、發明說明（ 37 等。本發明化合物有羥基時，可例示如令有羥基之化合 物與適當醯鹵或酐反應而得之醯氧基衍生物等前藥。 作爲前藥適宜之醯氧基如- OCOC2H5，-0C0(第三丁基）， -0C0Ci5H3i，-0C0(m-C00Na-Ph)，-OCOCH2CH2COONa，-OCOCH(NH2)CH3，-OCOCH2N(CH3)2)等。本發明化合物有胺基時，可例示 如令有胺基之化合物與適當醯鹵或混合酐反應而得之 醯胺衍生物等前藥。作爲前藥適宜之醯胺爲如-NHCO(CH2)20CH3，-NHCOCH(NH2)CH3 等。 本發明化合物不限於特定之異構物，包括所有可能之 異構物及消旋體。 本發明化合物乃如後述實驗例所示，具有優異之血栓 形成素受體激動作用，可用於血小板減少症（骨髓移植 後、化學療法後、再生不良性貧血、骨髓異形成症候 群、難治性突發性血小板減少性紫斑病等後天性血小 板減少症、血栓形成素缺損症等先天性血小板減少 症）等伴隨血小板數異常之血液病症之藥劑（血小板 產生調節劑）。可用以治療及/或預防投與抗癌劑所 請 先 閱 讀 背 面 意 項4 填 U:裝 頁I I I I I I I 訂 # 經濟部智慧財產局員工消費合作社印製 可 時 人 與 投 而 病 疾 述 上 療 治 以 物 ο 合 常化 異明 數發 板本 小用 血使 之當 致 以 ;又 予。 投予 口投 等胃 劑昜 i經 L fe— 丸 1-TV 0 ^ 膠製 ，皮 劑經 錠或 粒劑 顆入 ，吸 劑丨， 散劑 D栓 ， 爲劑 方射 處注 有= 物劑 合散 \Ί 崩 明劑 發合 製 其 合 適 合 混 時 要 必 量 效 等 劑 滑 ΒΕΙ、 或 劑 加 添 藥 注 劑 形 賦時 之 劑 劑 結 與 可 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 經濟部智慧財產局員工消費合作社印製 3 8五、發明說明（） 適當之載體一起滅菌處理作成製劑。 劑量視投予途徑，病人年齡，體重，性別而異，成人口服 時，每日每公斤體重一般爲約0.1〜lOOmg，宜爲 1 〜2 0 m g。 下面舉實施例及試驗例說明，但本發明不限於此。實 施例中所用縮寫如下。 Me :甲基 E t ·乙基 n-Pr ··正丙基 i-Pr :異丙基 c-Pr :環丙基 n-Bu :正丁基 secBu ：第二丁基 t-Bu :第三丁基 i-Bu :異丁基 n-Pen :正戊基 c-Pen :環戊基 n-Hex :正己基 i-Hex :異己基 Ph :苯基 Bn :苄基 B z :苄醯基 Py :吡啶基 A c ·乙釀基 -40- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐1 " (請先閱讀背面之注意事項¥琪寫本頁) -fi -1 L. · 裝 琪寫丄 訂---------鬌· 39 1284639 五、發明說明（ Z. Yf-M -g* •卡氧振碁 DMF : N，N_二甲基甲醯胺 THF :四氫呋喃 propargyl * 丙炔基 allyl :烯丙基 實施例 實施例1化合物（A -1、A -2及B - 1 )之製造
Β·1 (請先閱讀背面之注意事項再填寫本頁)
裝 訂---------0. 經濟部智慧財產局員工肖費^乍土，^— (第1工程） 將對苯二甲醛酸7.5g、烯丙基溴4.41ml及碳酸鉀 7.0g溶在DMF 1 0 0ml，在60°C攪拌1 6小時後，減壓蒸除 溶劑，分配在乙酸乙酯-水。乙酸乙酯層以碳酸氫鈉水 溶液、水、飽和食鹽水洗淨，以硫酸鎂乾燥，減壓蒸除 -41-本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 經濟部智慧財產局員工消費合作社印製 五 、發明說明（40) 溶劑，得化合物（2 )，無色透明油狀9.2 g。 旧 NMR(CDC13, δ ppm): 4.87 (2H, dt, J » 1·2, 5·7 Ηζ), δ·30 · δ.47 (2H, m)，5.99 • 6·12 (1H, m), 7.94 · 7·98 (2H, m)，8.20 · 8·25 (2H, m), 10.11 (1H, s)· (第2工程） 將化合物（2 ) 4· 3 7g及2-(三苯膦亞苯胺基）丙酸 乙酯10.63g溶在甲苯100ml，在70°C加熱攪拌1小時 後，減壓蒸除溶劑至約3 0〜4 0 m 1，濾除所析出之氧化三 苯膦。濃縮後，在矽膠柱層析（乙酸乙酯：正己烷 = 1:10)，得化合物（3 ),無色透明油狀6.9g。 NMI{ δ ppm): 1·:Κ;(川，l."J = 7.2 I⑻，2.H (:⑴，【|，fj = t Γ) 乂 (2Η. q, J = 7.2 Hz), 4.84 (211, dt, J = 1.2, 5.7 Hz), 5.28 - 5./1(5 (2H, m), Γ>.ί)8 - G.l 1 (1H. m). 7.43 - 7.47 (211, m), 7,(59 (111, d, ,) = 1.5 ilz), 8.0G - 8.1〇 (2Π, m). (第3工程） 將化合物（3 ) 6g、肆三苯膦鈀1.27g及嗎琳2.68g i谷在T H F 1 0 0 m 1，在6 0 °C攪拌3 0分後，減壓蒸除溶劑至 約30〜40ml，加乙酸乙酯，用碳酸氫鈉水溶液萃取3次， 合倂以3 Μ鹽酸水溶液酸化，析出之結晶以乙酸&目旨# 取，以飽和食鹽水洗淨，以硫酸鎂乾燥，減壓蒸除彳容齊II 5肖 化合物（4 )，白色結晶4 · 5 g。 III NMli (CDC1.3, δ ppm): 1.37 (·川，= 7.2 ll·/)，（1，J t 2 HZ) 4 3() (2H, q, J = 7.2 Hz), 7.49 (211, cl, J = 8.4 Hz), 7.71 (111, s), 8.14 (2H, d, J = 8.4 Hz) (第4工程） 將化合物（4) 1.05g及草醯氯1.3ml溶在THF 100ml，加触媒量DMF，在室溫攪拌2小時後，減壓蒸除 42- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 請 先 閱 讀 背 面 之 注 重裝 頁I 一 I I I I I I 訂 % 1284639 A7 B7 五、發明說明（ 41 經濟部智慧財產局員工消費合作社印製 溶劑，加甲苯。減壓蒸除甲苯，所得羧醯氯溶在二噚烷 70ml，力D 2 -胺基- 4-( 3，4 -二氯苯基）ργ 口坐ig及口比u定 970 // 1。在l〇〇°C加熱攪拌16小時後，分配在乙酸乙 酯-水。乙酸乙酯層以稀鹽酸、碳酸氫鈉水溶液、水、 飽和食鹽水洗淨，以硫酸鎂乾燥，減壓蒸除溶劑，得化合 物（A-1)，白色結晶1.5g。 NMli (DMSO·^ δ ppm): 1.2ί)(:川，t，,卜 7.2 Ik), 2.1()(叫 4.23 (2H, q, J = 7.2 Hz), 7.(52 - 7.Π8 (；Ui, m), 7.72 (111, d, ,! = SA Hz), 7.91 (III, s). 7.94 (III, (Id, J = 1.8, 8.4 Hz), 8.15 . 8,20 (211, m), 8.21 (III, d, J = 1.8 Hz). 12.84(lH?br). (第5工程） 將化合物（A-1 ) 1.7g、4M氫氧化鈉水溶液5.5ml 溶在THF 15 0ml，在8 5 °C攪拌18小時後，以稀鹽酸水溶 液酸化，濾、集析出之結晶，所得粉末以甲醇及乙酸乙酯 洗淨，得化合物（A - 2 )，白色粉末1 . 5 g。 ΠΊ NMU (l)MSO-dr), δ ppm): 2.08 (:UI，（l"J = (U) Πζ)，7.«2 · 7·(;8 (311，m)· 7.72 (1H. d, J = 8.7 Hz), 7.92 (III, r), 7.1)5 (HI, dd, Λ = 2.1, 8.7 Hz), 8.1(5 - 8.20 (211. m), 8.22 (III* d, J = 1.8 Hz), 12.(III, hr). (第6工程） 將化合物（A-2) 690mg及草醯氯420// 1溶在THF 15 0ml，加触媒量DMF,在70 °C攪拌1小時後，減壓蒸除 溶劑，加甲苯。減壓蒸除甲苯，所得羧醯氯加THF 100ml 而冰冷。另在28%氨水20ml加冰冷乙醚及氫氧化鈉 5g，攪拌10分而靜置後，注入上述羧醯氯之THF溶液中， -43- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 請 先 閱 讀 背 之 注 意 事 項 再
I裝 本 · 頁 I I 1 I I I I 訂 I I I I 1 m 1284639 A7 B7 五、發明說明（ 42 在冰冷下攪拌1小時後，分配在乙酸乙酯-THF-水。有 機層以稀鹽酸、碳酸氫鈉水溶液、水、飽和食鹽水洗 淨，以硫酸鎂乾燥，減壓蒸除溶劑，在矽膠柱層析（乙酸 乙酯：正己烷=10:1〜乙酸乙酯），得化合物（B-1 )，無 色結晶400mg 。 】H NMIt (DMSO-dU，δ ppm): 2.(M (:UI, (1，J = 1.Γ> Ιΐζ)’ 7·18 (1Π，l)r)，7·32 (1H，❸， 7.52 - 7.58 (2H, m), 7.60 (1H, hr), 7.72 (111, (I, el = 8.1 Hz), 7.91 (1H. s), 7.94 (1H. dd. J =： 2.1, 8.4 Hz), 8.14 - 8.19 (211, m), 8.22 (IH, (I, el = 2.4 Hz), 12.81 (HI, br). 實施例2化合物（A-7)之製造
第1工程
第2工程
先 閱 讀 背 之 注
言裝 本 . 頁 I I I I I I I 訂
(第1工程） 將4-乙醯基苯甲酸1.64g及草醯氯1.31ml溶在THF 3 0 m 1，加触媒量D M F，在室溫攪拌2小時後，減壓蒸除 溶劑，加甲苯。減壓蒸除甲苯，所得羧醯氯加THF 50ml、第三丁醇1.15ml及吡啶1.21ml，加熱回流40小 時後，分配在鹽酸冰水-乙酸乙酯。乙酸乙酯層以碳酸 氫鈉水溶液、水、飽和食鹽水洗淨，以硫酸鎂乾燥，減 壓蒸除溶劑，在矽膠柱層析（乙酸乙酯··正己烷=1 : 5 )， 得化合物（7)，白色結晶2.0g。 -44- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公爱） 蟄 經濟部智慧財產局員工消費合作社印製 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 43 五、發明說明（） III NMK(CDC1.3, δρρπι): 1.61 〇)H, κ), 2.ίΜ κ), 7.i)f； - 7.00(211, m), 8.01 - 8.0ί) (2Η, τη). (第2工程） 將氫化鈉（60%,3 60mg )懸浮在THF 1 0ml，冰冷下加 2-膦酸基丙酸三乙酯2.1 4g。攪拌30分後，在冰冷下滴 加化合物（7) 1.9g之THF 15ml溶液。在50°C攪拌3 小時後，分配在鹽酸冰水-乙酸乙酯。乙酸乙酯層以碳 酸氫鈉水溶液、水、飽和食鹽水洗淨，以硫酸鎂乾燥， 減壓蒸除溶劑，在矽膠柱層析（乙酸乙酯：正己烷 = 1:15)，得化合物（8)，無色油狀l.Og。 】H NMR(CDC13, δ ppm): 1·35 (3H, t, J = 7.2 Hz), 1·60 (9H, s), 1.74 (3H, q，J = 1.5
Hz), 2.24 (3H, q, J = 1.5 Hz), 4.27 (2M, q, J = 6.9 II/), 7.18 - 7.22 (2H. m), 7.97 -8.10 (2llf m). (第3工程） 將化合物（8 ) 9 0 0 m g溶在甲酸（9 8〜1 0 0 %，1 0 m 1)，在 室溫攪拌3小時後，減壓蒸除溶劑，加甲苯而再濃縮，在 正己烷濾集，得化合物（9 )，白色結晶68 0mg。 】H NMR(CDCl3, δ ppm): 1.3Γ》（3Π, I，J = 7·2 1卜/)，1.74 (311，（1· J = 1.Γ) llz). 2.2G (3H? q, J = 1.5 Hz), 4.28 (2II, q, J = 7.2 Hz), 7.25 - 7.2ί) (211, m), 8.10 - 8.14 (2M. m). (第4工程） 以化合物（9 )爲原料，仿實施例1-第4工程反應， 得化合物（A-7 )。 iH NMIVCDCh，δ ppm): 1.3Γ) (:Ui，I,, *1 = 7.2 Πζ), 1.W (:31[，（1，J = 1.5 ίΐζ), 2.25 (3H, q, J = 1.5 Hz), 4.28 (2H, q, J = 7/2 Hz), 7.20 - 7.29 (211, m), 7.44 (III, cl, J = 8.4 Hz), 7.61 (III, dd, J = 2.1, 8.4 Ilz), 7.91 (III, (I, = 2.1 Hz), 7.91 - 7.95 (2H, -45- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 丨—.——l·----裝------ (請先間讀背面之注意事項再填寫本頁)
訂---------W 1284639 A7 B7 44 五、發明說明（ m)，10.09 (III，br). 化合物(Α·3)〜(Α-6)、（Α·8)〜(Λ·1Ό7)、（Β·2)〜（IMG)、（CM)〜（C.5)、⑴.^ 〇 〜(Ε·2)、（F-l)〜(F-3)、（F-1)〜(F·;”、〜((㈣^ 兑 ' 汉 U * 1) 〜（I _ 6 )仿實施例1及2合成。化合物A之物理常數 如表1〜1 〇，化合物B之物理常數如表1 1〜1 7，化合 物C之物理常數如表1 8，化合物D之物理常數如表 1 9，化合物E之物理常數如表2 0，化合物F之物理常 數如表21，化合物G之物理常數如表22〜23，化合物 Η之物理常數如表24〜2 5，化合物I之物理常數如表 2 6 ° 閱 讀 背 之 注 項 再 填 寫 本 頁 經濟部智慧財產局員工消費合作社印製 6 4 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 _ B7 五、發明說明（“） 表1
化合物 No. R6 to R2 ΐ||·ΝΜΙ“Ι)Μί«)(1·ίί) Λ·:3 H II Et I.2H (illl, t, J = 7.211/), 4.22 (2It, q, J = 7.2Hz). fl.HO (HI, (I, J = 1(5.511/), 7.72 (III, d fJ = SAIL·), 7.73 (111, d, el = 15.9Hz), 7.88 - 7.93 (3H, m), 7.94 (1 i l, (Id, J = 2.1, 8.7Hz), 8.12 - 8.18 (211, m), 8.21 (111,(1,^1= I.HIIz), !2.H4(!H,h). Λ-4 II II II (i.70 (11 1 (I, J = 1Γ>.ί)ΙΙζ), 7.67 (III, d, J = 15.9Hz), 7.72 (ltf，（1，J = 8.711/), T84 (2Π, ni), 7.f)2 (111, s), 7.95 (111, (Id, J = 1.8, 8.1 Hz), 8.12 - 8.18 (2H. m), 8.21 (III, (I, J = 2.1112).12.57 (111, br), 12.84 OH, h). Λ-5 H Et Kt 1.13 (Ull, t, el = 7.2Πζ), 1.30 (311, t, J = 7.2Hz). 2.Π0 (211, cj, el = 7.2Mz), AM (2IIt q, J = 7.2IIz). 7.577 (111，h)，7.(W) - 7·Γ>3 (2Π, m)，7.72 (Ul, d, J = 8.7Hz), 7.02(111, s), 7.95(111, dd, J= 1.8, 8.41 Iz), 8.10-8.20 (211, m), 8.21 (III, d, J= 1.8IIz)12.85 (Hi, hr). Α-6 °， H Et II 1.ΚΗ·ηΐ, t, J = 7.5 ⑽,2.47 (211, q, J = 7.2Hz), 7.Γ》Γ) · 7.60 (2H，m), 7.61 (1H· s), 7.72 (111，d, J = HAU/l 7.f)1 (1M, 8),7.95(111, dd, J = 2.1, 8.4FIz). 8.15 - 8.20 (2H, m), 8.21 (HI, d, J = 2.1Hz), 12.76 (111, hr). Α-8 Me Me II 1.71 (：IM, (1, Λ = 1.,^Hz), 2.22 (3H, d, J = 1.2IIz). 7.：)7 - 1Λ2 (211, m), 7.73 (111, d, J = 8.4Hz), 7.92 (Ilf, η), 7.ί)Γ> (III, dd, J = 2.1, 8.4Mz), 8.13 - 8.18 (211, m), 8.22 (111, d, J = 2. Ill·/), 12.77 (1Π, br). Λ·9 F H Me Et; 1.20 (311, t, el = 0.911/), 2.10 (311, d J = 1.81Iz), Ί.23 (2Π, q, J = 0.911/), 7.^18 - 7.57 (1H, m). 7.62 -7.(18 (；H1, m), 7.78 - 7.85 (2H, m), 7.93 - 8.10 (til, m), 8.ΙΠ - 8.20 (2H, m), 12.85 (111, br). Λ-10 H • Me II 2.07 (Mil, (1, eJ - 1.511/), 7.47 - 7.57 (III, m), 7.G2 -7.(57 (311, m), 7.79 - 7.85 (2H, m), 7.93 - 8.01 (111. m), Η.ΙΓ) - 8.20(211, m), 12.81 (111, br). Λ-11 c,-p~ H Cl Et 1.:^ (;UU,，J = 7.2 llz), (211, (i，J 二 7.2 Hz), 7.72(111, (1, J = 8.1 flz), 7.93(311, s), 7.94 (1H. dd. el - 2.1, 8.1 II/), 8.CH (2H, d, fI = 8.7 Hz), 8.08 (III, r), 8.21 (HI. (I, J - 2.4 Hz), 8.21 (2H, d, J = 8.7 Mz), 12.91 (lll,s). Λ-12 II F lit 1.2(U·川，<，J = 7; llz),小27 ⑵ 1, q, J = 7.5 Hz), (U)i (111,(1,4 = 21 11/),7.22(111.8), 7.42(111, d, ^ Η. 1 1 Iz), 7.55 (21L - 8.1 1 Iz), 7.(«) (III. dd. .1- I.HII/, H.l llz), 7.87(111,(1,.1 = 2.1 Hz), 7.87 (211,(1, J-8.1 ll·/), 10.15(111,8) 47 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注音？事項再填寫本頁)
1284639 A7 B7 五、發明說明（4 ) 經濟部智慧財產局員工消費合作社印製 合物 No. Re Ri R2 U「】 ilI-NMR(l)MSO d-(5) A-13 卞 H Nil Z Mo ；V(H (III, h), 5.12 (211, η), β.ΠΓ) (111, s), 7.32 (211, (1, J = HA II/), 7.35 - 7.Ί2 (511, m), 7.72 (HI, d, ,1 =8.7 IIz), ΊΜ (1H, cld, eJ = 1.8 Hz, 8.7 Hz), 8.06 (2ΙΙ,(Ι,.Ι = Η,Ί 11/),8.21 (1llcl. I.BTIz), Π.：^Π (III, h), i).：H)(lll, h), 12.8(3(111, h) Λ-14 ci-p- H Cl Ii 7.73 (III, (1, eJ = 8.4 llz), 7.94(111, s), 7.95 (III, dd, J = 2.1, ΆΑ Hz), 8.04 (2H, d, J = 8.1 Hz), 8.05 (III, r), 8.21 (2H, (1, J = 8.1 Hz), 8.22 (III, d, J = 2.1 11/), 12.90 (III, s), 13.84 (Ul,bs) Λ-15 H Br Mo ：ί.Γ>Γ) (；UI, s), (5.84 (111, s), 7.5(5 (2H, d. J = 8.4 llz)f 7.72 (III, d, J = 8.1 Hz), 7.93 (1H, s). 7.95 〇H. eld, J = 8.4, 2.1 11/), 8. ΙΓ, (211, d, J = 8.1 Hz), 8.22 (III, del = 2.1 Hz), 12.90 (lH,s) A-16 H Br II 0. 72 (111, h), 7.58 (2!i, dt J = 8.^1 Hz), 7.72 (1H. d, = B.川/)，7·ί)3 (1IL h)，7.% (111, d(l, J 二 1. H Hz), 8.12 (211, d, J = 8.4 Hz), 8.22 (1H, cl J = 2.4 llz),】2.88(111, bs) A-17 b- II Me Et 7.15 . 7.21 (III, rn), 7.20 - 7.84 (6H, m), 7.47 -7M (IM, m), 7.87 (MI, s), 8.24 (211, d, J = 8.5 II/), 12.97(111,8), 13.97 (III, bs) A-18 b- II Me 11 2.07 (311, (I, \A Mz), 7.12-7.21 (III, m), 7.47 .ΊΜ (III, m), 7.(M (211, d, J = 8.5 Hz), 7.66 (III, h), 7.74 - 7.78 (HI, m), 7.80 - 7.84 (III, m), 7.85 (111, «), 8.18 (211, (1, J = 8.5 IIz), 12.63 (111. bs), 12.85(111,8) A· 19 F3V H Me Et I.UOGHM, J = 7.1 II/), 2.10(311, (1 J= 1.4 Hz), 4.23 (2H, q, J = 7. t Hz), 7.33 · 7.36 (1H. m), 7.58 (1H, t, J = 8.0 Hz), 7.65 (211, d, J = 8.5 Hz), 7.67 (MI, r), 7.91 (III, s), 7.93 (1H, bs), 7.99 - 8.02 (HI, m), 8.19 (211, d, el = 8.Γ3 Hz), 12.85 (IH, s) Λ-20 f3co 5- II Me 11 2 07 (mi, (1"1 = 1.4 llz), 7.M - 7.3(3 (1H, m)，7.57 -7.GC5 (/111, m), 7.91 (111, a), 7.94 (111, m), 7.99 -8.02 (HI, m), 8.18(211, d, e! = 8.5 Hz), 12.08(111, bn), 12.85 (III, s) Λ·21 ύ MeO F H Me lit l.2f)(；»l, t, ei = 7.1 II·/), 2.l()(3H,d. J= 1.7 llz), •18i> (311, s), 123 (211· (1，J = 7. niz)，7.22 · 7.28 (HI, m), 7.63 - 7.GG (411, m), 7.74 - 7.80 (2H, m), 8.18 (211, (1，J = 8.5 Πζ), 12.80 (III，bs) Λ·22 ύ MeO F H Mo II 2.07 (3M, cl, f! = 1Ί Hz), 3.89 (311, s), 7.22 - 7.28 (IH, m), im · 7.G7 0H, m). 7.75 - 7.81 (211, m), 8.18 (211, (1, Λ = 8.5 Hz), 12.80 (III, bs) Λ-23 F"〇- H Mo Kt 1.21) (HI 1, t , J = 7.1 117), 2.10 ( 3H, d, J = 1.4 Hz). 4.23 (2H, q, 4 = 7.1 11/), 7.2G · 7.32 (411, m), 7.G；i -7.00 (Mil, m), 7.(«) (111, s), 7.97 · 8.02 (211, m), H. 18 (2H, cl, J = 8.5 il/), 12.83 (111, bs) Λ-24 F分 II Mo 11 2.0H(；Ui, (l,el= 1.1 II/), 7.20-7.:^2(211. m), 7.(M (211, (1, ,1 - 8.Π II/), 7.(5(} (III, s), 7.704 (111. s), 7.0H - 8.0：l (2il, m), H. I8 (211, d, J = 8.5 Hz). 12.85(111, bs) 48 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 丁 ϋ ϋ ϋ n ϋ ϋ · «1··· ϋ n ·ϋ ΒΒ1 ^1 I (請先閱讀背面之注咅？事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 化合物 No. Ri R2 Rr> HI-NMK (l)MSO d-(5) Λ-25 Φ f3c H Me Et 1.29 (；)!!, t, J = 7.1 I iz), 2.10 ( 3Π, d, J = 1.4 II·/), i.23 (211, (j, J = 7.1 Hz), 7.ΠΊ · 7.07 (311 m). 7.83 (2li, d, J = 8.5 Hz), 7.95 (III, s), 8.17 - 8.20 (411, m), 12.f)：l(!!I,l)s) Α·26 ύ F3C H Me II 2.()7(；111,<1^1 1.1 11/),7.05(211(1..1 8 2 1!/), ΊΜ (III, 8), 7.8：} (211, d, J = 8.5 Hz), 7.96 (III, s), 8.17 (2f L d, J = 8.2 Hz), 8.18 (2H, cl, J = 8.5 Hz), 12.ί)；}(1Π, h) Λ·27 Or F3c H Me Et, 1.29 (；ΠΙ, tt J = 7.1 Hz), 2.10 (；31l, d. J = 1.4 Hz), 4.2：) (2fi, q, el = 7.1 II·/), 7.(M - 7.72 (511, m), 7.97 (HI, «), 8. If) (211, (1, J = 8.5 IIz), 8.25 - 8.28 (HI. m), 8 ；W(IH, s), 12.80 (lIU)s) Λ-28 F3c II Me 11 2.08 (311, (1, ,1 = U Hz), 7.68 (211, d, J = 8.2 H/). 7.00 (Ilf, s), 7.71 (III, cl, J = 5.2 Ilz). 7.})1 (III, s). 8.18 (211, (1, J = 8.2 Hz), 8.26 - 8.28 (111. m). 8.：W (III, bs), 12.87(111, s) Λ-29 F H Cl Kt 1..13 (311, t, J = 7.1 Ilz), 4.32 (211, q, J = 7.1 Ilz), 7.15 - 7.21 (1H, m), 7.47 - 7.5Ί (HI. m), 7.81 -7.H3 (HI, m), 7.8(5 (HI, s), 8.05 (2H. d. J = 8.5 11/), Η.0» (111, h), 8.22 (2H, cl, eJ = 8.5 Hz), 12.92 (111, M Λ-30 F H Cl II 7.10 - 7.21 (HI, m), 7A7 - 7.54 (1H, m). 7.75 -7.78 (1H, m), 7.81 - 7.84 (lit, m), 7.86 (HI, s), 8.(M (2H, (1, J = 8.2 Hz), 8.06 (1H, s), 8.21 (2H, d. J = 8.2Hz), 12.91 (111,8) Λ·31 f3co H Cl Et 1.M3 (3H, t, el = 7.1 Uz), ΛΜ (2H, q, J = 7.1 Hz), 7.34 - 7.3G (1H, m), 7.57 · 7.63 (HI, m), 7.92 (111, h), 7,iM (III, s), 7.99 - 8.02 (III, m), 8.05 (2H, d, J =8.5 Hz), 8.08 (HI, s), 8.22 (2H, d, J = 8.5 Ilz), 12.92 (UI, ba) Λ·32 F3cP~ H Cl II 7.；W - 7.3Γ5 (HI, m), 7.57 - 7.GM (HI. m), 7.93 (HI. s), (111, m), 8.0d - 8.0G (4H, m), 8.21 (2H, d. ,I = 8.2il·/), 12.5)2 (til, h) Λ·33 d MeO F II Cl Kt, I.J13 (H!f, t, eJ = 7.1 I iz), ；V88 (；lil s), 4.33 (211 q. J = 7.1 Ilz), 7.22 - 7.28 (III, m), 7.67 (III, s), 7.74 -7.80 (211, m), 8.05 (211, d, el = 8.5 Ilz), 8.09 (1H. h), 8.21 (211, (1, J = 8.5 12.88 (III, bs) Λ-34 ύ MeO F II Cl II H,H9 (311, s), 7.22 - 7.28 (1H, m)t 7.67 (III, s). 7,70 - 7.81 (211, m), 8.04 (2fl d, J = 8.5 Ilz), 8.05 (III, h), 8.21 (211, (I, J -8.5 Πζ), 12.87 (III, bs) Λ·35 F H Cl Et l.iW (8M, t, J = 7.1 Hz), 4.32 (2M, q, J = 7.1 Hz), 7.Ί8 - 7.57 (111, m), 7.80 - 7.85 (III, m), 7.83 (1H, h), 7.(H - Η.0Ι (111, m), 8.05 (211, d, J = 8.5 Hz), H.08 (111, h), 8.21 (211, d, J = 8.5 Hz), 12.91 (IH, bs) Λ-36 F II Cl II ΊΑΗ - 7.5H (111. m), 7.80 - 7.85 (111, m), 7.8；^ (HI. η), 7·ίΜ · 8.01 (111，m)，a(M (211，（1, fl 二 8.Γ> 11/)， 8.05 (III, h), 8.21 (211, d, eJ = 8.5 Hz), 12.92 (III. l)H) 1284639 ΚΙ _____Β7 五、發明說明（〇 ) Ίί) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁)
1284639 A7 B7 五、發明說明) 表4 經濟部智慧財產局員工消費合作社印製 化合物 No R6 Rl R2 RR MI-NMR (DMSOd-G) A-37 11 Cl Et \/M\ (311, t, rl = 7.1 Hz), ^1.32 (211, q, J = 7.1 Ilz), 7.20 - 7.32 (2M, m), 7.71 (1H, s), 7.98 - 8.02 (2IL m), 8.04 (211, d Λ = 8.5 Hz), 8.09 (1H, s), 8.21 (211,(1, J = 8.511/), 12.91 (lH.hs) Λ-38 H Cl II 7,2“ - 7.:i:"*2ll, m), 7.72 (111, h)· 7.!m . Η()·Ί (211, m), 8.04 (211, d, rl = 8.5 11/), 8.05 (111, s), 8.21 (211, d, J = 8.5 Hz), 12.92 (III, bs) Λ-39 ύ F3C II Cl Et m (3f ί，t.，J = 7.1 1 Iz), 32 (2f Ϊ, (i, ?J = 7.1 Ϊiz), 7.8,1 (211, (1, J = 8.4 Hz), 7.97 (111, s), 8.05 (2H. d, J = 8.5 11/), 8.0» (1 ί I, s), 8.18 (211, d. J = 8.4 Hz), 8.22 (211, (1, J = 8.Γ3 Hz), 13.00 (lli s) A-40 f3c H Cl II 7.8H (2! I, cl, ei = 8.5 Hz), 7.9G (111, s), 8.04 (2M, cl rl = 8.5 Mz), 8.06 (1H, s), 8.18 (2H, d. J = 8.5 Hz), 8.22 (2il, cl, J = 8.Γ, II/), 12.97 (HI, bs) Λ-41 ρ- f3c H Cl Et l.a：i (；m, t, rJ = 7.1 Hz), 4,33 (2H, q, J = 7.1 llz), 7.7(). 7·72 (2H，m), 7.98 (1H, s), 8.05 (2H，d, J = 8,5 Hz), 8.()9 (HI, s), 8.22 (211, d, J = 8.5 Hz), 8.25 - 8.28 (III, m), 8.；W (Ml, bs), 12.92 (III, s) A-42 ρ- F3c H Cl II 7.70 - 7.72 (2M, m), 7.98 (1H, s), 8.04 (2II, d, J = 8.5 II·/), 8.00 (IM, s), 8.22 (2H, d, J = 8.5 Hz). 8.24 · 8.28 (HI, m), 8.33 (111, bs), 12.92 (1H, bs) A-43 C|尹 H F II 7.15 (1H, (1, J = m/λ Hz), 7.73 (III, d, J = 8.4 Hz), 7.8(5 (2H, (1, eJ = 8.7 Hz), 7.97 - 7.94 (211, m), 8.18 (211, d, J = 8.4 Hz), 8.22 (III, d, J = 2.1 Hz), 12.89 (Hi,») A-44 p- f3c H F II 7.20 (Ul, cl, J = 23.1 Hz), 7.68 (2II, d, J = 8.5 Hz). 7.7« (III, 8), 7.97 (III, 8), 8.12 (2H, d, J = 8.5 Hz), 8.25.8.28 (III, m), 8.33 (Hi, bs), 12.84 (1H, bs) Λ-45 p- F3co H F II 7.1» (1M, (1, el = 22.8 Mz), 7.33 - 7.56 (tH, m). 7.57 - 7.(53 (1H, m), 7.Γ>8 (211, d, J = 8.5 Hz). 7.91 (III, h), 7.i)4 (III, bs), 7.1)9 · 8.02 (III, m), 8.11 (211, (l,J = 8.5 Hz), 12.8；}(HM)s) Λ·4Γ) f3c II F II 7.20 (ΙΠ, (1, ef = 22.9 1 Iz), 7.f58 (211, d, J = 8.5 1 Iz). 7.8IJ (211, (1, J = 8.5 Hz), 7.9(5 (1H, s), 8.12 (2H, d, eJ = ar)II/), 8.18(211,(1, el = 8.5 11z), 12.91 (III, s), 13.87 (1U,bs) Α·47 H Cl II 7.3!) · 7.45 (HI, m), 7.^18 · 7.54 (2H, m), 7.G7 -7.73 (3H, m), 7.77 - 7.81 (211, m), 8.03 - 8.07 (3H, m), 8. If)-8.25(311, m) Α-48 t-Bu^ II Cl H \.l)2 (Oil, r), ΊΜ (2f 1, d, el = 9.0 Hz), 7.64 (III, s), 7.H!) (2!1, (1, A = 9.0 Hz), 8.01 - 8.06 (311, m), 8.22 (2II,(l,eI = 8.1 Hz), 12.89(111,«), 13.90 (111, bs) Λ·4ί) n.Pen^ H Cl II ().H7(；nU，,,J = 7.2 11/), 1.2(5- U>0 (211, (|iiint , J = 7.8 I I/), 2.(50 (211, U J = 7.5 Uz), 7.27 (211, (1, el = HA II/), 7.04 (III, r), 7.87 (2H, d. ,1 =- 8.1 Hz), H.02 - 8.0Π m), 8.2! (21L d d -HA Hz), 12.88 (III, s), I：179 (Hi, bs) 50 (請先閱讀背面之注意事項再填寫本頁)
本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 B7五、發明說明（Μ ) 表5 經濟部智慧財產局員工消費合作社印製 化合物 No. Ri R2 m-NMR(l)MSC) (|.(>) Λ-50 ----- d- H Cl II 7.ίί() - 7.^1(5 (：1ΙΙ, rn), 7.6H (HI, d, J = 2.4 Hz), 8.0；i -8.07 (3M, m), 8.12 (HI, id, J = 1.8 Hz, 7.8 Hz). 8.22 (211, d, J = 8.7 Hz), 12.93 (III, s), 13.85 (til, hs) Α·51 F H Cl II 7.li) - 7.2H (211, m), 7.47 - 7.Γ>7 (211, m), M.OI -8.05 (：»!, m), 8.21 (211, d, J =： HA Hz), 12.97 (!H, s), 13.80 (lH,bs) Λ-52 H Cl II ,182 (；UI, h), ().85) - (>.JH (HI, m), 7.：H5 (HI, t, J = 8,1 Hz), 7.53 - 7.ΠΠ (211, m),7.75 (III, s), 8.02 -8.00 (3!l, m), 8.21 (211, d, J = 8.4 Hz), 12.88 (1IL h), 13.82(111, hs) Α·53 ^Jr H Cl H «.GO (III, (Id, J = 1.8 liz, 3.3 Hz), β.75 (III, d, J = 3,3 tl·/), 1Λ\ (1M, r), 7.75 (1Π, d, J = 1.8 IIz), 8.01 - 8.(M OH I, m), 8.21 (211, d, A = 8.7 Hz) Α-54 H Cl II 7.37 (III, m), ΊΛ\) 7.58 (；UI, m), 7.β5 (111, dt, J =1.8 Hz, 8.1 Hz), 7.71 - 7.76 (2II, m), 7.88 (III s), 7.97 (III, clt, eJ = 1.8 11¾. 7.5 Hz), 8.03 - 8.06 (：HI, m), H.2：i (211, d, J = 7.8 H/), 8.28 (IH, t, J = 1.8 11/), 12.90 (1Π, 8), 1··ί.82 (1Π, l)s) Α-55 n-Bu II Cl II ().i)2 (；m, t, J = 7.5 Hz), 1.；M (2M. soxt, J = 7.5 ll·/), 1.00 (211, ciuint, <1 = 7.B Hz), 2.04 (211, t J = 7.5 \b)f 7.17 (III, d, J = 7.8 ilz), 7.35 (IH, t, J = 7.5 M/.), 7.70 (III, s), 7.7(5 (1H, d, J = 7.8 Hz). 7.81 (1H, r), 8.02 - 8.05 (311, m), 8.22 (211, d, J = 8.4 Hz)12.8G (1Π, s), 13.84 (III, hs) Α-56 F H Cl H 7.24 (III cR, eJ = 5.8 IIz, 2/3 Hz), 7.40 (1H, ddd, J =11.9 Hz, 9.4 Hz, 2.5 Hz), 7.59 (1H, d J = 2.5 Π/), 8.(M (2M, d, el = 8.5 Hz), 8.05 (1H. s), 8.09 -8.20(111, m), 8.21 (211, d, el = 8.5 Hz), 12.93(111, s), 13.82(111, bs) Α-57 II Cl M 7.Γ)Γ, (III, = H.() llz)，7.77 · 7.H1 (2U, m>, 8.(M (211, (1，J = Η·5 l lz)，8.0G (1Π,、s)，8.22 (211，（1，J 二 8.5 Hz), 8.37 - 8A2 (HI, m), 12.99 (1H, s), 13.85 (III, bs) Α-58 H Cl II 7.22 - 7.30 (1H, m), 7.37 - 7.40(111, m), 7.72 (111, (1, e! -*= 2.5 Hz), 8.04 (2H, d el ^ 8.5 Hz), 8.05 (HI. s), 8.21 (211，（1, J = 8.5 Hz), 12.92 (1H，s>, 13.82 (Ul.bs) Α-59 ύ n-BuO H Cl II 0.92 · (),07 (311, m), \A\ - 1.49 (211 m), 1.67 -1.7Γ» (2Π, m), 4.01 (211, t, J = β.8 Hz), 7.00 (2H, cl J = 8.Γ) Uz), 7M (Ul, r), 7.87 (211, d, J = 8.5 IIz), 8.(M (2fi, (1, ei = 8.5 IIz), 8.05 (HI, s), 8.21 (211, cl. eJ = 8.nilz), 12.85(111,8), 13.7(5 (III, bs) Α-60 f3c H Cl H 7.74 - 7.70 (III, m), 7.82 (111, d, J = 2.7 Hz). 7.80 -7.8Ί (III, in), 8.03 - 8.05 (311, m), 8.22 (211, d. ,1-8.5 11/),8.31 (11U, el = 7.(5 Hz). 13.01 1,17()(111 bs) Α-61 MeO H Cl 11 ：V8；t (：m, r), (5.91 - 0.5)8 C2H, m), 7.45 (III, cl, J = 2.5 II/), 8.00 (4!I, m), 8.21 (2H, d, J = 8.5 Hz). Ι2.Η8(ΙΠ, s), l；V81 (Ul.bs) 51 (請先閱讀背面之注意事項再填寫本頁)
本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 五、發明說明（0) 經濟部智慧財產局員工消費合作社印製 化合物 No. R6 IV R2 Rr* U|.NMIl(l)MSO (U；) A-62 F F H Cl II 7,OH (III (1, ,1 = 2.5 Hz), 7.(58 - 7.7G (UI, m), 7.80 -8.07 (411, m), 8.20 (2H, d, J = 8.5 llz), 12.92 (1H , h) A-63 Br 11 Cl 1! 7.^18(111, i, Λ - 8.8 II/), 7.8Γι (1H, s). 7.Π8 - 8.0：^ (III, m), H.()4 (211, <1,,卜 Η.Π II/·), Η()Γ、（III,叭 H.21 (211, (1, Λ = 8.5 Hz), 8.30 (111,.(1(1, J = G.5) 11/, 2.2 11/), 12.88 (111, s), 13.82 (111, bs) Λ-64 Φ i-Bu H Cl 11 0.89 (OH, d, J = G.7 Hz), 1.87 (1H, sovon, J =ll7 11/), 2AH (211, (1, J - 7.M Hz), 7.28 (2H, d. ei - 8.2 II/), 7.(54 (III, s), 7.87 (2M, d, ,1 = 8.2 Hz), 8.(M (2II, (1, J = 8.5 117), 8.05 (1H, s), 8.21 (2H, d, J = 8.5 Hz), 12.88 (111, s), 13.70 (111, bs) A-65 f3c 0- f3c II Cl II 8.02 - 8.05 (411, m), 8.05 (III, s), 8.22 (2H, d, J = 8.5 Hz), 8,27 (MI, s), 8.04 (211, s), 12.94 (III, s), VIM (III, bs) Λ·66 Me -|s|^y^ o H Cl H 3.8Θ (3H, s), 7.17 (1H, t, J = 7.5 Hz), 7.25 (1H. t. el = 7.5 Hz), 7.38 (1Π, s), 7.50 (HI, d, J = 8.4 llz), 7.78 (III, r), 8.03 - 8.0β (3H, m), 8.17 (III. d. J = 7.8 IIz), 8.22 (211, d, eJ = 8.4 Hz), 12.79 (III, bs) Α·67 0 l NMe Me· H Cl II 2.H5 (Π1Ι, s), 3.52 (2H, i, el = 5.4 Hz), 4.41 (2H, t, el 5.4 Πζ), 7.0Π (2M, d, J = 8.7 Hz), 7.60 (111, s). 7.f)3 (2U, (1, J = 8.7 Hz), 8.01 · 8.05 (3H, m), 8.21 (211, (I, el = 8.7 Hz), 12.84 (1H, bs) Α-68 fO~ H F II 7.15 (IH, cl, J = 36 Hz), 7.24 - 7.33 (211, m ), 7.70 (!H, r), 7.86 (211, d, el = 8.4 Hz), 7.96 - 8.03 (211 ,m), 8.18 (2h, cl, J = 8.7 Mz), 12.86 (111, s) Λ-69 d-F Br厂 II Cl 里I 7.57 (III, (Id, J = 8.7 Hz, 1.8 Hz), 7.67 (1H, d, J = 2A Hz), 7.70(111, (Id, el = 11.4 Hz, 2.1 Hz). 8.02-8.09 (ΊΙ Ι, m), 8.21 (211, d, J =： 8.7 llz)f 12.97 (III, s)f 13.09(111, bs) Λ-70 Me H Cl H 2M (3Π, s), 7.13 - 7.19 (211, m), 7.54 - 7.55 (1Π, m), 7.98 - 8.06 (411, m), 8.22 (211, d, J = 8.4 IIz), 12.89 (Hi, s), 13.80(111, bs) Α-71 H Cl II 7.U9 - 7.45 (III, m), 7.51 (2H, t, J = 7.8 Hz), 7.67 -7.72 (311, m), 7.79 (211, d, J = 8.4 Mz), 8.03 - 8.07 (311, m), 8.19-8.25(311, m), 12.97 (lH,s), 13.8G (111,1)8) Λ-72 ft" 11 Cl ii 7.:K) - 7.4H (2"，m)，7.72 ("I· d, J = 2.4 Hz), 7.88 -T.m (HI, m), 8.()/1 (211, d, el = 8.5 Hz), 8.05 (III. h), 8.22 (211, (1. ,1 = 8.5 Hz), 12.5)6 (ill, s), 13.83 (HI, bs) Α-73 (XX H Cl ii 2.00 - 2.10 (211, m), 2.8(5 - 2.JM (411, m), 7.29 (1Π, (1, ,1 = 7.7 llz), 7.(;1 (111, s), 7·72 · 7.7Π (111, m), 7.H2 (111, a), 8.0Ί (211, d, J = 8.5 Hz), 8.05 (IH, s), H.21 (2II,d,J = 8.511/), 12.84(111, s), 13.84(111. 1>h) 52 (請先閱讀背面之注意事項再填寫本頁) 訂--------- 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 ___B7 五、發明說明（W ) 表7 化合物 No. R6 IV R2 m.NMR(l)MSC) d-G) A-74 ca H Cl II ：V2i (2H, t, ei = 8.5 II/), 4.57 (211, t, J = 8.8 11/), Π.83 (Hi, d, el = 8.2 Hz), 7.49 (1H, s). 7.73 (III (Id, J = 8.2 IIz, l.G IIz), 7.82 (III, s), 8.04 (211, d 4 = 8.5 IIz), 8.0Π (HI, s). 8.20 (2H. d, J = 8.5 Hz). l2.K；t(lll,l)H) 一 — Λ-75 H Cl II 7.ΠΙ (III, i, el - i).I 11/), 7.H0 (111, s), 7.ί)Γ> - 8 00 (III, m), 8.04 (211, d, e! = 8.5 Hz), 8.05 (HI, s), 8.16 (III, (Id, el = 1A Mz, 2.2 Hz), 8.22 (2H, cl. J = 8.511/), 12.1)0 (Hi, hs) A-76 F3C〇^ H Cl II 1M (2)1, cl, J = H.H Hz), 7.72 (HI, s), 8.04 (211 d, Λ = 8.5 Hz), 8.06 (111, s), 8.09 (2H, d, J = 8.8 Hz). 8.22 (211, cl, J = 8.5 Hz), 12.9(3 (III, s), 13.86 (HI. 1)8) Λ-77 F F II Cl 11 7.70 (III, (1, J = 2.4 11/), 7.81 - 7.91 (III, m). 8.0；^ (211, (1, e! = H.5 Hz), 8.(M (III, s), 8.20 (211, d, J = 8.5 Hz), 12.05 (1H, s), 13.81 (1H, s) Λ-78 ύ MeS II Cl n 2.52 (311, r), 7.34 (211, d, el = 8.5 Hz), 7.69 (III, s). 7.91 (2M, (1, el = 8,5 llz), 8,04 (211 d, J = 8.8 Hz), 8.00 (111, h), 8.21 (2Π, d, J = 8.5 liz), 12.91 (III l)s) Λ-79 F3C F H Cl H 7.58 ·7.ίΗ (111, m), 7.79 (111, d, e) = 2.5 Hz). 7.79 -l,m (111, m), 8.0Ί (211, d, el - 8.5 Hz), 8.0G (111, h), 8.22 (211, (1, J = 8.5 I Iz), 8.52 (HI, dd, J = 6.9 Hz, 2.2 Hz), 12.93 (1H, s), 13.72 (III, bs) A-80 H Cl H 7.39 - 7.55 (511, m), 7.56 - 7.62 (2H, m), 8.05 (2H. (1, J = 8.5 Hz), 8.06 (III s), 8.13 (1H, td, J = 7.8 Hz, 1.8 Hz), 8.23 (2H, d, eJ = 8.5 Hz), 12.96 (III, s), 13.82(111, bs) Λ-81 II Cl II 7.M0 (lh, it eJ = 8.1 I l·/), 7.G8 - 7.74 (211 m), 8.02 -8.05 (311, m), 8.10 (111, id, J = 7.8 11/. 1.8 Hz). 8.21 (2II,d, J = 8.7 11/), 12.9G (111, s), 13.82 (lh, l),s) Λ·82 Q- MeO F H Cl II lim (211, r), 7. H - 7.27 (211, m), 7.G0 - 7.G8 (2H, m), 8.02 - 8.0G (311, m), 8.21 (211, d, J = 8.4 Hz), 12.92(111,8), 13.80 (11U)h) Λ-83 II Cl H 2/Λ2 (3H, d, J = 1.8 Hz), 7.21 (HI, t, J = 7.5 llz), 7.25 - 7.31 (1M, m), 7.61 (1M, d, eJ = 2.7 Hz). 7.94 (lit, td, J = 7.5IIz, 1.8 Hz), 8.02 - 8.06 (311, m). 8.21 (211, d), 12.91 (HI, s), 13.80 (HI, bs) Λ-84 H Cl n 0.H4 - 0.90 (311, m), l.；«) - 1.37 (4H, m), 1.5G -Ι.ββ (211, m),. 2.08 (2H, 1, e) =： 7.3 Hz), 7.20 - 7.30 (211, m), 7.f5! (Ill, d, Λ = 2.7 Ilz), 7.1)5 (1H, td J = 7.M 11/, 2.1 11/), 8.(M (211, d, J = 8.5 Uz), 8.0G (III, h), 8.21 (211, (!, el = 8.5 Hz), 12.88 (III. s), 13.89(111, bs) Μ I---— — — — —----— — — — — — ^ ·1111111 (請先閱讀背面之注音？事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7
五、發明說明（卜） 丧8 經濟部智慧財產局員工消費合作社印製 化合物 No. Ri R2 Ur) UI-NMU (DMSOd-f)) Λ85 n-Pen H C! II O W} · 0.i)() m)，丨.:K) - 1.:37 ⑼，m)， \M (21 f, m),. 2.Π5 (211, 1, .1 - 7.G Hz), 7.18 - 7.24 (III, m), 7.69 (HI, s), 7.79 - 7.84 (1H, m), 7.87 -7.5)1 (1H, m), HM (2H. d, J - 8.5 Hz), 8 Οβ (HI. η), H.22 (211, <1, A Μ.Γ» llz), I2.!)2 (III, h), MOO (111, 1)h) Λ-86 H Cl 11 7.28 (III, td, J = 9.1 Hz, 1.8 Hz), 7.64 (111, s), 7.8t - 7.8Π (III, m), HM (2H, cl, J = 8.5 Hz), 8.05 (1H, h), 8.20 (211, (I, eJ = 8.5 IIz), 13.01 (IH, s), 13.93 (III, hs) Λ·87 Me H Cl II 2.：U (311, h), 2.41 (3U, s), 7.08 (1H, dd, J = 7.7 11/, IA II·/), 7.18(111,(1, J = 7.7 Hz), 7.33 7.^19 (\Hf d, J = \A Mz), 8.05 (2H, d, J = 8.5 IIz), 8.20 (2II, (1, J = 8.5 Hz), 12.85 (1H, bs) Λ·88 F H Cl II 7.：M - (3H, m), 7.4?) (Id, J = 7.5 Hz, 1.8 Hz), 7.02 - 7.68 (3! I, m), 8.03 - 8.06 (3H, m), 8.12 (1H. t,d, J = 7.Γ) Hz, 1.8 lb〇, 8·22 (2H, (1，J = 8.4 llz), 12.90(lll,s), 13.81 (Ul,bs) Λ·89 H Cl H 7.31 - 7.37 (HI, m), 7A\ - 7.GG (711, m), 8.03 (2H, cl, J = 8.5 11/), 8.05 (lit, b), 8.21 (211, d, J = 8.5 II/), 13.00 (HI, bs) Α·90 F3C Br H Cl H 7A9 (1H, r), 7.70 (III, d, J = 8.5 Hz), 8.02 - 8.10 (41 f, m), 8.19 (2H, d, J = 8.5 Hz), 12.97 (1H. s), 13.82(111, bs) Λ-91 H Cl H 7./18 (III, t, J = 7.9 Hz)t 7.69 (111, dd, J = 7.9 Hz, 1.Γ) Hz), 7.74 (111, r), 7.81 (1H, del J = 7.9 Hz, 1.8 Mz), 8.04 (2H, (1, J = 8.5 Ilz), 8.06 (1H, s), 8.21 (2II,d,ef = 8.5 11/), 12.5)5)(111,8), 13.87 (llLbs) Λ-92 Cl 0- Cl H Cl 11 7./17 (1H, (hi, J = 8.G 11/, 2.7 Hz), 7.G2 (1Π. d, J = HA llz), 7.88 (III, s), 8.02 - 8.05 (411, m), 8.21 (211, d, J = 8.4 Uz), 12.93 (III, s), 13.88 (1IL bs) Λ-93 Φ n-Hex H Cl II ().8()(811,^,1 = 0.9 117), 1.27- 1.30 (Glim). 1.55-1.02 (2H, m),. 2.G8 (211, t, .1 7.5 Hz), 7.19 - 7.30 (211, m), 7.G1 (III, d, J = 2.71Iz), 7.94(111, dt. J = 7.0 Hz, 2.0 II/), 8.03 (2H, d, J = 8.5 Hz), 8.05 (111, r), 8.21 (211, d, J = 8.5 Hz), 12.92 (III, s). 1：1.80(UI, bs) Λ·94 H Ci H ia.70(bs, 111), 12.?)：Kbs, 111), 8.2l(d, 2H, J = 8.2 H/), 8.06(s, 1H), 8.(H(d 2R el = 8.2 Hz). 1.94(dU Ml, el = 7.5, 2.0 11/), 7.01((1, Ul J = 2.7 Hz). 7.M2(m, 111),7.25(1., 1H\ ,J = 7.5 Hz). 2.90(mt 111). l.2(M.i)0(m, 1011) Λ-95 d-F F n-Hex II Cl II (⑽· O.Hi) (··川，m)，1.27 · K;讥（411, ni), l .W ^ 1.00 (211,111),. 2.G；l(2IU. ,I-7.7Ilz), 7.11-7.17 (III, m), 7.：M - 7.41 (III, m), 7.Π1 (III, s). 8.0；^ ⑵ 1，d，J = 8.厂> 1切，8.0Γ) (lfl, h), 8.20 8.Γ)!Ιζ), 12.00(111, s), 1；1.78 (MU)s) ΓΗ 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁)
Ι284639 Α7 Β7 五 表 發明說明（ο ) 9 經濟部智慧財產局員工消費合作社印製 化合物 R6 Ri R2 MI-NMIl (l)MSO d-G) A-96 ----— Q- n-BuO F H Cl II (M)G (；m, t, el = ΊΛ Hz), 1.41 - 1.54 (211, m), 1.70 -1.78 (2H, m),. 4.08 (211, t, J = G.4Hz), 7.13-7.24 (211, m), 7.(51 - 7.66 (211, m), 8.03 (211, d J =： 8.6 Hz), 8.05 (1!it s), 8.21 (2H, d, J = 8.6 Hz), 12.92 (III, h), I；IHI (III, I)h) Α·97 H Cl II I.2M (；HI, 1, A = 7.5 11/), 2.72 (211, q, ,1 = 7.Γ) 11/), 7.21 - 7.33 (211, m), 7.G1 (tH, d, J = 2.5 Hz), 7.95 (lit, del, ei = 7.5 TIz, 2.0 Hz), 8.04 (2H, d, J = 8.5 Hz), 8.05 (1H, s), 8.21 (211, d, J = 8.5 liz), 12.92 (III, h), 13.85(111,1)8) Α·98 H Cl II 0.88 (ΗΠ, (1, J = 6.(5 Hz), 1.19 - 1.26 (2H, m), 1.53 -Ι.βΟ (311, m),. 2.6β (211, t, J = 7.7 IIz), 7.20 -7.30 (2H, m), 7.(51 (HI, d, J == 2.7 IIz), 7.95 (111, dd, J = 7.5 Hz, 2.2 Hz)t 8.04 (211, d, J = 8.4 Hz). 8.05(IH,r), H.21 (211, (1, J = 8.4 Ilz), 12.92(111. s), 13.80(111, bs) Α·99 n,R~ H Cl II Ο.ίΜ (311, i, J = 7.5 II/), 1.63 (2H, soxt. J = 7.5 Hz), 2.67 (2H, t, J = 2.67 Mz), 7.20 - 7.31 (2H. ni), 7.(U (1Π, (L J = 2.7 Πζ), 7.95 (111，UlJ = 7·5 Πζ, 2.4 IIz), 8.02 - 8.06 (3M, m), 8.22 (211, d, J = 8.4 11/), 12.92 (1Π, s)，13·7ί) (III, Α-1〇〇 Q- H Cl II 〇 {)2 (；ll l, i, el = 7.5 II/), 1.35 (2H, soxt. J = 7.5 II/), 1.5Π (211, cjuini, el = 7.5 iiz), 2.G9 (211 t. J = 7.5 Hz), 7.19 - 7.30 (2il, m), 7.61 (HI, d, eJ = 2.7 \h)f 7.04 (III, id, J = 8.2 Hzt 2.4 IIz), 7.99 - 8.06 (311, m), 8.21 (2M, d, J = 8.4 Hz), 12.92 (1H, s), 13,80(111, bs) Λ-101 ：P-R- II Cl II 0.5)8 (III, t, e! = 7.5 Hz), 1.60 (211. sext, J = 7.5 II/), 2.77 - 2.83 (2H, m), 7.59 (III, d, J = 8.4 Hz), 7.00 (UI, (1, J = 3.0 Hz), 7.91 (III, t, J = 8.4 Hz), 8.01 . 8.07 (3Π, m), 8.21 (211, d J = 8.7 Hz). 12.ίΜ(ΙΠ, 8), 13.80 (IIU)s) A. 102 c? H Cl II TAG (HI, U J = 8.1 Hz), 7.54 - 7.60 (211, m), 7.70 (III, d, J = 2.7 Hz), 7.95) - 8.07 (4H, m), 8.17 (1H. (Id, el = 8.2 II/M 1.8 Hz), 8.21 (211, d, J = 8.4 IIz), 8.(iG (1Π, l》s), 8.83 (1Π，1>h), 12.97 (111，s) Α-103 EtR H Cl Π 1.M9 (3K, t, eJ = 7 0 Hz), 4.15 (2!I, q, J = 7.0 Mz). 7.13 - 7.25 (211, m), 7.(52 - 7.67 (2H, m), 8.04 (2H, (1, J = 8.5 Πζ)，8.06 (1Π，s), 8.22 (2H, d, J = 8.5 I!z), 12.94 (111, s), l；i.8(}(lll,bs) A-104 H Cl H 2.H9 - 2.1)8 (411, m), 7.17 · 7.GI (711, m), 7.61 (III, (l, J = 2.5 Hz), 7.95 (III, dt, J = 7.4 IIz, 2.2 Hz), 8.04 (2H, d, J = 8.6 Hz), 8.05 (1H, s), 8.21 (2H, d, J » 8.Θ Hz), 12,92 (1H, 8), 13.86 (1H, bs) A-105 H Cl H 0.97 (ΘΗ, e), 1.45 - 1.50 m), 2.62 · 2.68 (2H, m), 7.19 - 7.30 (2H, m), 7.62 (1H, d, J = 2.4 Hz), 7.94 (1H, dt, J = 7.5 Hz, 2.1 Hz), 8.04 (2H, d, J = 8.5 Hz), 8.06 (1H, s), 8.22 (2H, d, J = 8.5 Hz), 12,92 (1H, s), 13.85 (1H, bs) 55 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁)
1284639 A7 ___B7 五、發明說明（Μ ) 表1 0 化合物 No. R6 IV R2 IlR MI-NMIl(DMSO d-G) Λ-100 π CI II 1.10 (3li, t, J - f).f) 11/), 2.Π3 (211. t, J - G.9 Hz). ,1./1(5 (211, (i，el = (i.{) Ilz), ；U；2 (211, t, J = G.9 Hz), 7.24 (III, t, A = 7.Γ, II/), 7.33 (III, td. J = 7.2 Hz, I.H 11/), 7 ill (III, (1. J 2.7 II/)· 7 ”7 ,1 7.2 11/, 1.8 1 Iz), H.02 - «.()(} (；H 1, m), 8.21 (211, d d = 8.411/), 12.93(111,h), 1,189 (III, bs) Λ-107 Η C1 II 4.00 (211, r), 7.18 - 7.35 (7H, m), 7.61 (1H, d J = 2.7 Hz), 7.5)8 (III, td, Λ = 7.5 Hz, 2.1 Hz), 8.02 8.05 (：HI, m), 8.21 (211, d, e) - 8.7 Ilz), 12.92 (1H, h), 1,186 (lH,bs) | 裝--------訂--------- (請先閱讀背面之注音？事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 _ru\ 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 128463兮 A7 B7 五、發明說明（κ) 表1 1
經濟部智慧財產局員工消費合作社印製 了匕合物 No. R6 Ri R2 R iH-NMR(DMSO d-6) Β·2 Η Η -NHa 6.77 (1H, d, J « 15.9Hz), 7.20 (1H, br), 7.50 (1H, d, J « 15.9Hz), 7.60 (1H, br), 7·72 (1H, d , d = 8.7Hz), 7.72 · 7·76 (2H, m), 7.91 (1H, b), 7.95 (1H, dd, J = 1.8, 8·4Hz), 8.14 · 8.18 (2H, m), 8·22 (1H，d， J= 1.8Hz), 12.82 (1H, br). Β·3 Η Η -ΝΗΜθ 2.73 (3H, d, J = 4.8Hz), 6.75 (1H, d, J = 15.6Hz), 7.50 (III, d, J = 15.Gliz), 7.72 (1H, d, J = 8·1Ηζ>, 7·72 · 7.75 (2H, m)， 7.91 (1H, s), 7.95 (1H, dd, J = 2.1, 8.4Hz), 8.09 - 8.18 (3H, m), 8.21 (1H, d, J = 2.1Hz), 12.81 OH. br). Β·4 Η Me •ΝΗΜθ 2.06 (3H, d, J = 1.5Hz), 2.72 (3H, t, J = 4.5Hz>, 7.27 (1H, 8), 7.53 · 7.58 (2H, m)， 7·72 (1H, d, J = 8.7Hz), 7·92 (1H，s)， 7.95 (1H, dd, tl = 1.8, 8.1Hz), 8.07 (1H， q, J = 4.2Hz), 8.13 · 8.18 (2H, m)，8.22 (1H, d, J = 2.1Hz)· 12.81 (1H, s). Β·5 Η Me ·Ν(Μθ)2 2.05 (3H, d, J = 1.5Hz), 3.32 (6H, s), 6.57 (1H, s), 7.54 - 7.58 (2H, m), 7.72 (1H, d, J = 8.4Hz), 7.91 (1H, s), 7.95 (1H, dd, J = 1.8, 8.4Hz), 8.13 - 8.18 (2H, m), 8.22 (lH.d, J 1.8Hz), 12.79 (1H, br). Β-6 Η Me •NHEt 1.10 (3H, t, J = 7.2Hz), 2.05 (3H, d, J = 1.2Hz), 3.17 - 3.26 (1H, m), 7.25 (1H, s), 7.54 - 7.58 (2H, m), 7.72 (1H, d, J = 8·4Ηζ>, 7.91 (1H, s), 7.95 (1H, dd, J == 2.1, 8.1Hz), 8.09 (1H, t, J = 5.4Hz), 8.13 -8.18 (2H, m), R21 (1H, d, J = 2,1Hz), 12.80 (1H, β). ί Β·7 Ψ Η Me -NH(n-Pr) 0.89 (3H, t, 7.2Hz), 1.51 (2H, sextet, d = 7.2Hz), 2,06 (3H, d, J = 1.5Hz), 3.11 -3.18 (2H, m), 7.25 (1H, s), 7.54 - 7.59 (2H, m), 7.72 (1H, d, J = 8,4Hz), 7.92 (1H, s), 7.95 (1H, dd, J =2·1, 8.4Hz), 8.10 (1H, t, J = B.4Hz), 8.14 - 8.19 (2H, m), 8.22 (1H, d, J = 2.1Hz), 12.82 (1H, 8). Β·8 Η Me o 2.06 (3H, d, J = 1.2Hz), 3.53 · 3.58 (4H, m), 3.60 - 3.64 (4H, m), 6.60 (1H, s), 7.54 -7.61 (2H, m), 7.72 (1H, d, J = 8.7Hz), 7.91 (1H, s), 7.95 (1H, dd, J = 2.1, 8.7Hz>, 8.13 · 819 (2H, m), 8,22 (1H, d, J = 2.1Hz), 12.80 (1H, br). 57 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ϋ .^1 ϋ ϋ ϋ I ϋ n ϋ ϋ n I ϋ ϋ ϋ ϋ 一-0, ϋ ϋ ϋ ϋ I ϋ I I (請先閱讀背面之注咅？事項再填寫本頁) 1284639 A7 B7 五、發明說明（h) 經濟部智慧財產局員工消費合作社印製 表1 2 化合物 No· R6 Ri R2 R m-NMU (DMSOd-6) 13-9 Η Me •NHBn 2 10 (：»I, (1, Λ = 1.511/), 4.41 (211, d, J = (5.()11/), 7.52 - 7,38 (GU, m), 7.50 - 7.GI (2!I, m), 7.72 (ill, d, J = 8.4Hz), 7.92 (Uf, 8), 7·ί)Γ，（111, (1(1· J = 2.1, 8.4H7). Η. M - H.20 (211, m), K.22 (III, d, J 2.4Hz), 12.82(111, br). B-10 Η Me -^o 2.22 (3H, i, J = 1.2Hz), 7.34 (III, dt, J = 1.2, 8.1Hz), 7.47 (1H, dt, J= 1.2, 8.4Hz), 7.65 - 7.71 (ini m), 7.73 (1H, d, J = 8.4Hz), 7.78 (1H, d, J = 7.8Hz), 7.94 (1H, s), 7.96 (1H, dd, J = 2.1, 8.4Hz), 8.02 (1H, d, J « 8.2Hz), 8.19 - 8.24 (3H, m), 12.63 (1H, br), 12.89 (1H, br). B-11 Η Me 2.18 (3H, d, J * 1.5Hz), 7.27 (1H, d, J = 2.4Hz), 7,5β (1H, d, J = 3.3Hz), 7.59 (1H, br), 7.63 - 7.68 (2H, m), 7.73 (1H, d, J = 8.4Hz), 7.93 (1H, s), 7.96 (1H, dd, J =2.1, 8.4Hz), 8.17 · 8.22 (2H, m), 8.23 (1H, cl, J = 2.1Hz), 12.36 (1H, br), 12.87 (III, br). B-12 Η Me 2.18 (3H, d, J = 1.2Hz), 7.37 - 7.43 (2H, m), 7.64 - 7.69 (2H, m)t 7.73 (1H, d, J = 8.4Hz), 7.94 (1H, s), 7.96 (1H, dd, J = 1.8, 8.4IIz), 8.16 (1H, td, J= 1.5, 6.9Hz). 8.18 - 8.24 (3H, m), 8.31 (1H, dd, J = 1.5, 4.5Hz)8.89 (1H, d, J = 2.4Hz), 12.87 (III, br). B-13 Η Me 2.11 (3H, d, eJ = 1.2Hz), 4.49 (2H, d, J = 6.0Hz), 7.36 (1H, br), 7.52 - 7.62 (4H, m), 7.G9 - 7.74 (3H, m), 7.92 (1IL s), 7.95 (III, dd, eJ = 2.1, 8.1Hz), 8.15 - 8.20 (2H. m), 8.22 (HI, d, J = 2. lllz), 8.79 (1H, t, J =6.3Hz), 12.83(111, br). Β·14 Η Me 2.09 (311, d, J = 1.2Hz), 4.38 (2H, d. J = 5.7Hz), 7.13 - 7.20 (2H, m), 7.32 - 7.39 (311, m), 7.55 - 7.Θ1 (2H, m), 7.73 (1H, d, J = 8Mh), 7.92 (III, s), 7.95 (III, del J =2.1, 8.4IIz), 8.14 - 8.19 (2H, m), 8.22 (1H, (1，J = 2.1Hz)，8.71 (III, t，J = a〇IIz), 12.84 (III, br). Β-15 Η Me 2.08 (3H, cl, J = 1.5IIz), 4.55 (2H, d, J = 5.7Hz), 6.96 - 7.03 (2H, m), 7.31 (1H, hr), 7.40 (1M, dd, J = 1.5, 5.4Hz), 7.55 -7.00 (211, m), 7.73 (111, cl J = 8.4IIz), 7.92 (til, s), 7.95 (111, dd, J = 2.1, a4I Iz)t 8.14 - 8.19 (2H, m). 8.22 (1IL d. J = 2.1II/), 8.80 (11 1, t, J = O.OHz). 12.84 (III, br). 58 (請先閱讀背面之注意事項再填寫本頁) 冒裝 ---丨訂--— — — — — — · 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 厂___B7 五、發明說明（β ) 表】3 化合物 No. R6 R1 R2 R U I-NMR(i)MSO d-G) B-16 Η Me 、tn°> 2.07 (311, (1, J = 1.2llz), 4.;«) (211. (1, J 二 5.7Hz), 6.28 (111, d, J = 3.6IIz), 6.41 (HI, dd, J = 1.8, 3.3Mz), 7.30 (1H, br). 7.55 - 7.G1 (3H, m),7.73 (1H, d J = H.III/), 7.1)2 (111, η), 7.ΠΓ) (Ul, dd, ,1 2.1, 8.411/), H.H - 8.18 (211, in). 8.22 (HI, (1, J = 2.1Hz), 8.63 (III, t, Λ = (U)Hz), 12.84 (1H, br). Β·17 c,p- Η Et .NII2 1.07 (311, t, J = 7.2Hz), 2.47 (2H, q, J = 7.2Hz), 7.20 (2H, br), 7.48 - 7.53 (2H. m), 7.65 (Ul, br), 7.73 (1H, cl J = H.UIz), 7.93 (111, r), 7.95 (1H, dd J = 2.1, 8.4U/), 8.13 - 8.18 (2II, m), 8.22 (HI, (1, J = 2.1Hz), 12.83 (1H, br). Β·18 c,p- Η Et -NHMg Ι.0Γ) (：UI, t, ,1 = 7,5 Hz), 2AH (211, q. J -7.51l·/), 2.72 (211, d, J = 4.5 IIz), 7.11 (tM, s), 7.48 - 7.53 (2H, m), 7.73 (III, d, J = 8.4 TIz), 7.92 (III, s), 7.95 (IH. dd, J =2.4, 8.11Iz), 8.08 - 8.18 (3H, m), 8.22 (1H, d, J = 2.411/), 12.82 (III, br). Β·19 c,p- Η Et -NilBt 1.05 (311, t, J = 7.5IIz), 1.10 (3H, t, J = 7.2Πζ), 2.48 (2II, q, J = 7.2IIz), 3.16 -：120 (211, m), 7.09 (111, s), 7.48 - 7.53 (2tl, m), 7.73 (III, d, eJ = 8.4Hz). 7.93 (til, s), 7.1)5 (IH, dd, J = 2.1, 8.41Iz), 8.M - 8.20 (2H, m), 8.22 (HI, cl J = 2.1Hz), 12.8Ί (Ul.br). Β·20 c,p- Η Et -NIlHn 1.08 (3H, t. J = 7.5IIz), 2.52 (2H, q, J = 7.8Hz), 4.41 (2H, d, J = 6.3Hz), 7.18 (1M, s), 7.22 - 7.40 (5ΙΊ, m), 7.50 - 7.54 (2M, m), 7.73 (HI, cl, J = 8.4Hz). 7.93 (HI, s), 7.95 (1M, dd, eJ = 1.8, 8.4Hz), 8.14 · 8.18 (2H，m), 8.22 (1H，d J = 1.8llz), 8.75 (MI, i, J = 6.0Hz), 12.84 (Ul,l>r)· Β·21 Me .Me •mu 1.70 (311, (1, el = 1.2Hz), 2.04 (3il, d J = 1.2Hz), 7.21 (1H, br), 7.35 - 7.41 (2H, m), 7.52 (1H, br), 7.73 (III, d, J = 8.4Hz), 7.92 (1Π, s), 7.95 (III, dd, J = 2.1, 8.41 Iz), 8.13 - 8.18 (2H, m), 8.22 (111, d, J = 1.8Hz), 12.80 (lFLbr). Β-22 Me Me •Nil Mo 1·(ί9 (31i, d，J = 1.2Hz), 1.99 (3Γ1，d J = 1.5Hz), 2.69 (3H, d, J = 4.5IIz), 7.36 -7.41 (2H, m), 7.73 (UI, d, J = 8.4Hz), 7.Π2 (III, s), 7,95 (1H, dd J = 2.1. 8.4!l·/), 7.5)5) (III, (|, el = 4.8Hz). 8.13 · H.18 (211, m), 8.22 (III, d, el = 2.UIz>, 12.80(111, br). 55) (請先閱讀背面之注音？事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） A7 B7 1284639 五、 表 發明説明 經濟部智慧財產局員工消費合作社印製 7^物 B-23 R6 Ri R2 U UI.NMIKDMSO d-6) Cl-^— Mo Mo •NIIKt. 1.10 (；UI, t, J = 7.2llz), 1.6f) (311, d, J = 1.2IIz), 2.00 (3M, cl, J = 1.5Hz). 3.14 -3.23 (2H, m), 7.30 - 7.41 (211, m), 7.73 (HI, (1, λ = 8.411/), 7.92 (HI. s), 7.9Π (III, dd, Λ 2.1, H ()(i (III, t, el 5,411/), 8.13 - 8.17 (211, m), 8.22 (111, d, J = 2.1Hz), 12.80(111, br). B-24 Me Mo •NIIBn 1.73 (3H, cl, J = 1.5Hz), 2.00 (3H, d, J = 1.5Kz), 4.39 (2H, d, J = 5.7 Hz), 7.22 -7.Ί2 (711, in), 7.73 (1H, d, J = 8.4IIz), 7.92 (HI, s), 7.95 (IH, dd J = 1.8. 8.41 Iz), 8.12 - 8.18 (2Π, m). 8.22 (111, d, l.HUz), 8.62 (III, t, J = 6.3Hz), 12.80 (lit, br). Β*2·5 F H Mo -NH2 2.(M (ail, d, J = 1.211/), 7.20 (til, br), 7.32 (1H, br), 7.48 - 7.64 (4H, m), 7.79 -7.86 (2H, m), 7.94 - 8.02 (1H, m), 8.14 -8.18(211, m), 12.83(111, br). Β-26 F-P- F H Mo -NHMo 2.0G (3H, cl, el = 1.2Hz), 2.72 (3H, d, J = 4.8Hz), 7.26 (III, b), 7.47 - 7.58 (3IL m), 7.78 - 7.87 (211, m), 7.94 - 8.02 (III, m), 8.08 (HI, q, eJ = 4.5IIz)8.13 - 8.18 (2H, m), 12.82 (111, br). Β·27 H Me •NII(Cil2)2- N(CIl3)2 2.05 (3H, cl, J = 1.2 Hz), 2.19 (611, s). 2.39 (2H, t, J = 6.9 Hz), 3.28 (2H, q, J = (if) IIz), 7.26 (1H，br), 7·55 (2H，d, J = 8.7 Hz), 7.72 (HI, cl J = 8.1 Hz). 7.91(1 H, s)t 7.95 (1H, dd, J = 2.1 IIz, 8.1 Hz), 8.01 (III, t, J = 5.7 Hz), 8.16 (2H d. el = 8.7 Hz),. 8.22 (1M, cl el = 2.1 Hz). 12.83( 111,br) Β·28 Cl會 H Me .NU(CIb)2· COOIi 2.05 (31 i, cl, ef = t.5 Hz), 2.49 (311, t, J =7.5 Hz), 3.3» (211, q, J = 6.0 Hz), 7.2G (HI, hr), 7.5fi (2II, d, J = 8.7 Hz), 7.73 (11Γ, clt eJ = 8.4 Hz), 7.93 (1H, s), 7.95 (IH, dd, J = t.8 Hz, 8.4 IIz), 8.16 (211, d. J = 8.7 IIz),. 8.22 (III, d, J = 1.8 IIz), 12.90 ⑵I, br) Β·29 H Me -NHN(Cil3)2 2.05 (3Π, s), 2.56 (Oil, s), 7.14 (1H. s), 7.50 (2M, d, el = 8.1 Hz), 7.73 (III, d, J = 8.1 II/), 7.f)3 (1H, s), 7.95 (1H, del J = 18 I8.1 1 Iz), 8.16 (211, cl, J = 8.1 Hz),. 8.22 (IH, d, J = 1.8 Hz), 9.08 (1H, s), 12.83 (Ulbr) Β-30 H Me •NllPh 2.17 (；m, d,,l = 1.1 Hz), 7.07 - 7.11 (IH. m), 7.32 - 7.：Π (311, m).7.G5 (211, d J = H.r, Hz), 7.7；» (：m, (i j = ar> ii/>. 7.α·ΚΙΙ1, s)· 7.9(KUI, (1(1，J = 2.2 Hz, 8.5 liz)t 8.20 (211, d, J = 8.5 IIz),. 8.22 (1H, cl, ei = 2.2 II/), lO.Ot (til, s), t2.85 (1H, H) (50 (請先閱讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7
經濟部智慧財產局員工消費合作社印製 化合物 _N〇. R6 Ri R2 R Ut-NMH (DMSO d-G) Β·31 Η Μο .NHCH2CF3 2,01) (；VII, d, el = U Uz), 4.02 (2H, m). ΊΜ (!M, h), 7.60 (2H, d, J = 8.4 Hz), 7.73 (1H, d, J = 8.5 Hz), 7.93 (1H, s), 7.95 (HI, (Id, J = 2.2 Ilz. 8.5 TIz). 8.18 (ail, cl, J - H H/)t. H.22(lll, d, el 2 2 Ilz), 8.75 (III, l·, J = 6.0 Hz), 12.85 (III, H) Β-32 c，^- Η Me .NM(CII2)3- SCII3 1.76 (211, qn, el = (5.9 Hz), 2.06 (6H, s), 2.49 - 2.53 (2H, m), 3.26 (2H, q, J = 5.7 lb〇, 7.2β (1H, 8), 7.57 (2Π, d，J = 8.4 Hz), 7.73 (til, d, J = 8.4 Hz), 7.92(1H, h), 7.95 (III, (Id, J = 2.1 Mz, 8.4 Hz). 8.15 (IH, t, J = 4.8 Hz), 8.16 (2H, d J = 8.4 11/), 8.22 (III, d, J = 2.1 Hz), 12.83 (MI. br) Β-33 αΡ~ II Me .NHCIKClla)- Ph t.46 (311, d, J = 7.2 Ilz), 2.08 (2H, d, J = 1.5 Hz), 5.08 (1H, qn, J = 7.2 Hz), 7.21 -7.41 (f5M, in), 7.69 (2H, d, J = 8.4 Hz), 7.72 (III, (1, el = 8.4 Hz), 7.92 (III, s), 7.95 (111, dd, J = 2.1 Ilz, 8.4 Ilz), 8.17 (211, (1, J = 8.4 Hz), 8.22 (1M, d, J = 2.1 Mz), 8A8 (Ml, d, J = 8.4 Hz), 12.83 (III br) Β-34 Η Me -NHClbSi- (011,3)3 0.06 (f)II, s), 2.06 (311, d, J = 1.2 Hz). 2.72 (2M, (i, J = 5.4 Hz), 7.18 (1H, s). 7.57 (211, (1, J = 8.4 Hz), 7.73 (IH, d, J = HA Hz), 7.93 (1M, s), 7.95 (1H, dd, J = 2.1 Hz, 8.4 Hz), 7.99 (1H, t, J = 5.4 Hz), 8.1G (211, d, J = 8.4 Hz), 8.22 (1H, d, J = 2.1 Ilz), 12.83(111,8) Β-35 Η Me -NII(M3u) 0.87 (311, t, .1 = 7.1 Hz), 1.11 (311, d, J = 0.6 Ilz), 1.41 - 1.57 (211, m), 2.06 (3H, d, J = 1.4 Hz), 3.83 (1Π, sexth, J = 6.G Ilz), 7.21 (111, s), 7.57 (2ΓΙ, d, J = 8.4 Ilz), 7.72 (1M, (i, J = 8.4 Ilz), 7.80 (III, d, J = 8.1 Ilz), 7.92 (1H, s), 7.95 (111, dd J = 2.1 Hz, 8A Hz), 8.17 (2H, d, J = 8.4 Hz), 8.22 (III, (1, J = 2.1 Ilz), 12.82 (1H, s) Β-36 II Me -NH(c.Pr) 0.52 - 0.70 (41 i, m), 2.04 (3H, d, J = 0.8 ilz), 2.74 - 2.80 (1H, m), 7.56 (2H, d, J = 8.1 Ilz), 7.72 (1H, d, J = 8.4 Hz), 7.92 (1H, s), 7.95 (1Π, (Id, J = 2.1 Ilz, 8.4 Hz). 8.11 (111, (1, J = 4.2 Mz), 8.16 (2H, d. J = 8.1 M/), 8.22 (111, d, J = 2.1 Hz), 12.82 (111,h) ▼裝--------訂---------^^1 · (請先閱讀背面之注音S事項再填寫本頁) G1 本紙張尺度適用中國國家標準(CNS)A4規格（210 X 297公釐） 經濟部智慧財產局員工消費合作社印製 Μ 1 β 化合物 No. R6 Ri R2 U Ul-NMR (DMSO d-6) B-37 Η Μη -N!i(CII2)nO-(:1 la 0.87 (3H, t, J = 7.1 Hz), 1.11 (3H, d, J = Π.6 Hz), 1.41 - 1.57 (2H, m), 2.06 (3H, d, J = 1.4 Hz), 3.83 (1H, sext.h, J = 6.6 Hz), 7.2Π (HI, s), 7.57 (211. d J - 8.7 U/V 7.7,1(111,(1,^1^8.1 11/), 7.!)Γ» (111, ild, f) =2.1 Hz，8.1 Hz>, 8.11 (1H, t, J 二 G.() Hz), 8.16 (2H, d, J = 8.7 Hz), 8.22 (1H, (1, J = 2.1 Hz), 12.83 (Ills) Β·38 C 丨 Η Me -NIKc-Pon) - 1.58 (411, m), 1.63 - 1.71 (2H, m). 1.81 - 1.90 (2H, m), 2.05 (311, s), 4.10 -4.15 (1H, m), 7.20 (III, s), 7.57 (2H, d· J =8.4 1 h), 7.7；l (III, d, J = 8.1 Hz), 7.92 -7.96 (3H, m),8.16 (2H, d, J = 8.4 Hz). 8.22 (1M, (1, J = 1.8 Hz), 12.82 (111. s) Β-39 Η Me •NH(t]3u) 1.35 (})11, s), 2.03 (311, d, J = 1.5 llz), 7.13 (III, s), 7.66 (211, d, J = 8.4 Hz), 7.72 (III, d, J = 8.4 Hz), 7.92 (1H, s), 7.9*5 (III, dd, J = 2.1 Hz, 8.4 Hz), 8.16 (2H, (1, J = 8.4 Hz), 8.22 (1H, d, J = 2.1 !iz), 12.82(111,8) Β·40 Η Me -Nllpropargyl 2.06 (3H, (1, J = 1.2 Hz), 3.12 (1H, t. J = 2.4 Hz), 3.98 (211, dd. J = 5.4 HZ. 2.4 ffz), 7.30 (III, s), 7.58 (211, d, J = 8.4 Mz), 7.73 (1H, d, J = 8.4 Hz), 7.20 (1H, h), 7.95 (UI, dd, eJ = 8.4 Hz, 2.1 Hz). 8.16 (211, (1, J = 8.4 Hz), 8.22 (1H, d, J = 2.1 Mz), 8.57 (III, J = 5.4 Hz), 12.83 (1H, H) Β·41 Η Me •NMnllyl 2.08 (3H, d, J = 1.2 Hz), 3.83 (2H, t, J = 5,7 IIz), 5.07 -5.21 (2H, m), 5.94 - 5.81 (III, m), 7.29(111, s), 7.58(2Π, d, J = R4 Hz), 7.73 (til, d, J = 8.7 Hz), 7.92 (1H, η), 7.ΓΜ (HI, (Id, J = 8A IIz, 1.8 Hz), 8.17 (2M, d, J = 8A Hz), 8.22 (111, rt, J = 1.8 M/), 8.31 (III, t, J = 5.7 Hz), 12.83 (111, H) Β·42 Η Me -NU(ClI2)2〇· Clla 2.00 (；3H, (l, ei = 1.2 Hz), 3.28 (311, s), iU7 - 3.46 (411 m), 7.27 (III, s), 7.57 (2H, (1, J = 8.7 Hz), 7.72 (1H, d, J = 8.4 Hz), 7.92 (tH, s), 7.95 (1H, dd. J = 8.4 Hz, 2.1 Hz), 8.15 (HI, s), 8.17 (211, d, J = 8.7 Hz), 8.22 (1H, <1，J = 2.1 IIz), 12.83 (III，s) Ι3·4:3 Η Me •NllNliAc l,f)l QMl s), 2.08 (311, d J = t.5 Hz), 7,32 (III, s), 7.59 (211, d J = 8.4 Hz), 7.7H (1Ht cl J = 8.4 IIz), 7.95 (III, dd J -=8.4 ll·/, 1.8 Hz), 8.18 (211, d, J = 8.4 llz), 8.22 (III, (1, J = 1.8 Hz), 9.81(111, h), !).f)5(lll, h), 12.85(111, s) 1284639 A7 ____B7 五、發明說明（k ) G2 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注音？事項再填寫本頁)
1284639 A7 五、發明說明（W ) 表1 7 經濟部智慧財產局員工消費合作社印製 化合物 No. R6 Ri R2 U iII-NMR (DMSO d-6) 13-如 C丨尹 II Mo .NliNllini 2.13 (311, d，J = L2 Hz), 6.73 (1H，t· J = 7.5 Hz), 6.80 (211, d, J = 7.8 Hz), 7.17 (211, t, eJ = 8.1 Hz), 7.38 (1H, s), 7.63 (2li, (l, J = 8.4 Mz), 7.73 (HI. d. J - 8 1 Hz), 7.H2 (111, d, el = 2.7 11/), 7.5)3 (111, h), 7.96 (111, (Id, J = 8.1 Hz, 1.81Iz), 8.10 (2H, (1, J = 8.4 Hz), 8.23 (1H, d, J = 1.8 Hz), 10.04 (1H, d, J = 2.7 Hz), 12.86 (m,8) Β·45 Η Me _N(C1I_I2 2.10 (311, s), 3.11 (811, s), 4.84 (211, bs), 0.59(111, s). 7.53 (2H. d. J = 8.1 Hz). 7.71 (til, cl J = 8.1 Hz), 7.85 (1H, s), 7.94 (III, dd, J = 8.1 Hz, 1.8 Hz), 8.15 (2Π, (1, J = 8.1 Hz), 8.21 (III, d J = 1.8 Hz), 12.63 (lH,br) Β-46 Η Me -NIIOCHs 2.03 (311, d, J = 1.5 Hz), 3.68 (3H, s), 7.20 (III, s), 7.57 (2H, d, J = 8.4 IIz)t 7.72 (IH, d, J = 8.1 Hz), 7.95 (1H, dd, J =8.1 Hz, 2.1 Hz), 8.16 (2M, d J = 8.4 Hz), 8.22 (III, cl, J = 2.1 Hz), 11.43 (III, 8), 12.84 (111, s) 03 |裝---- (請先閱讀背面之注意事項再填寫本頁) 訂---------慧- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 五、發明說明（卜） r< 1 8
化合物 No. Ri〇 Ri R2 Εβ iH-NMR (DMSO d-6) C-1 Η Me Mo 2 08 (3h, (I, J = 1.2 !Iz), ；UM (3U, s), (5.87 (III, s), 7.38 (211, d, J = 8.7 Hz), 7.72 (1H, (I, J = 8.7 Hz), 7.91 (1H. s). 7.9Γ3 (III, dd, eJ = 8.7 Hz, 2.1 Hz), 8.08 (2H, (1, J = 8.4 Hz), 8.21 (1H, d, J = 2.1 Πζ), 】2.79(1H，8) C-2 Η Me M 2.00 (；m, cl, eJ = 1.2Ilz), G.69 (111, s), 7.4G (2H, d, J = a〇 Hz), 7·72 (1H, d, J = 8.7 Hz), 7.92 (1H, r), 7.94 (1H, dd, J = 8.4 11/, 1.8 IIz), 8.08 (2H, d, J = 8.7 Hz). 8.22 (HI, d, eJ = 2.1 Hz), 12.77 (III s), 12.91 (III, s) C-3 Η Br Mo 3.76 (311, s), 7.48 (2II, d, J = 8.7 Hz). 7.69 (UI, s), 7.72 (III cl J = 8.4 Hz), 7.93 (111, s>, 7.95 (1H，dd, J = 8.4 Hz, 2.1 Hz), 8.11 (2H, d, J = 8.4 Hz), 8.21 (UI,(1，J = 2.1 Hz), 12.86 (Ill’s) C-4 Η Br H 7·Ί7 (1Π, s), 7.54 (2Π, d, J = 8.7 Hz)， 7.92 (IH, s), 7.95 (1H, dd, J = 8.4 Hz, 2.1 Hz), 8.11 (2H, d, J = 8.4 Hz), 8.21 (III, d, J= 1.8 Hz), 12.83(111, s) C-5 Η F H 7.19 (HI, d, ,1 = 23.1 Hz), 7.68 (2II.d .J =8/1 Hz), 7.73 (111, d, J = 8.1 Hz), 7.93 (1 H,s), 7.95 (Ui, dd, J = 8.1 Hz, 2.1 Hz). 8.11 (211, (1, e) = 8.1 Hz), 8.22 (lILd = 1.8 11/), 12.84 (Ul.s) —.—·-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 五、發明說明（W ) 表1 9
化合杨 No. Ri R2 Hot UI.NMHCDMSOd.G) D-1 Η Me 2.35 (3H, d, J = 0.9 Hz), 7.12 (2H, bs), 7.32 (1H, s), 7.58 (2H, d, J = 8.1 Hz), 7.72 (III d. J = 7.8 Hz), 7.92 (IH, s), 7.95 (1H, dd, J = HA Hz, 2.1 Hz), 8.17 (2H, d, J = 8.4 Hz), 8,22 (1H, d, J = 18Hz), 12.31 (lH,s), 12.79 (Ills) (請先閱讀背面之注意事項再填寫本頁) ▼裝--------訂--------- 經濟部智慧財產局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 五、發明說明（μ ) 表2 Ο Α7 Β7
化合物 No. Ri° Ri R2 R UI-NMH (DMSO d-G) Ε·1 H Mo anti OH 12.80(bs, 1H)f 11.20(s, lH),8.21(s, lfi), 8.15(d. 211, J = 8.3 Hz), 7.95(m, 1H), 7.93(s, UI), 7.90(s, 1H), 7.72(d, 1H, J= 8.5 Hz), 7.57(d, 2H, J = 8.3 Hz), 6.83(s, 1H), 2.10(s, 3H) Ε·2 c丨尹 H Me syn OM 10.60(bs, 1H), 8.12(d, 1H, J = 1.9 Hz), 8.03((1, 2H, J = 8.5 Hz), 7.87(dd, 1H, J = 8.5, 1.9 Hz), 7.58(H, 1 Π, J = 8.5 fh), 7.26(s, 1H), 7.16(d, 2H. J=8.2 Hz), (5,5(5(cl, III, J = 7,1 Mz), 3.20(m, IH), 2,51-2.80(m, 211), 0.98(d, 3H, J = 6.9 Hz) -----------裝--------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 Γ)β 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 __ B7 五、發明說明（W) 表2 1
化合物 No. Ri〇 Ri R2 R iH-NMR (DMSO d-6) F-1 Η Me •N(Me)2 (CDC13) 2.24(d, 3H, J = 1.5 Hz), 2.92(s, 6H), 7.24(s, 1H), 7.47(d, 1H, J = 8.2Hz), 7.52 (a, III), 7.53(d, 2H, J = 8.5 Hz), 7.64(dd, 1H, J = 8.2, 1.8 IIz), 7.93(d, 1H, J= 1.8 Hz), 8.00(d, 2H, J = 8.5 Hz), f).85(brs, til). F-2 c，^ Η Μο •Nli(t-Bu) (CDC13) 1.38(8, 9H), 2.28(d, 3H，J= 1.4 Hz), 419(s，1H>, 7.24(8, 11D, 7.49(cl, III, J = 8.2 Hz), 7.53(d, 2H, J = 8.5 Hz), 7.62(brs, 111), 7.66(dd, 1H, J = 8.2, 1.9 Hz), 7.96((1. HI, ei = 1.9 Hz), 8.03((1, 211, J = 8.5 Hz), 9.80(brs, III). F-3 Η Μο •Nila 2.25((1, 3H, J = 1.2 Hz), 7.17(s, 2H), 7.42(brs, 1H>, 7.04((1, 2H, J = 8.2 Hz), 7.73((1, 2H, J = 8.2 Hz), 7.92(8, til), 7.95(dd, MI, J = 8.2, 2.1 Ilz), 8.18(d, 211, J = 8.2 Hz), 8.22(d, IH, J = 2.1 Hz), 12.90(brs, III). —^---------^^^裝--------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 五、發明說明（W ) 表2 2
經濟部智慧財產局員工消費合作社印製 化合物 No. Ri〇 Ri R2 Ηβ m-NMli (DMSOd-G) G-1 Η II Me 2.07 (2H, t, J = 7.7 Hz), 3.02 (2II, t, J =7.7 Hz), 3.G5) (311, s), 7.20 (III, s), 7.26 (III, s), 7.29 (2H, d, J = 8.2 Hz), 7.41 (1M, d, J = 8.5 Hz), 7,58 (1H. (Id, J = 8.5 IIz, 2.2 Hz), 7.82 (2H, d, J =8.2 Hz), 7.86 (1H, d, J = 2.2 Hz), 10.15(111,1)8) (CDC13) G-2 Η II II 2.(51 (211, t, eJ = 7.3 Hz), 2.92 (2H, t, J =7.3 Hz), 7.42 (2H, d, J = 8.5 Hz), 7.41 (1H, cl, J = 8.5 Hz), 7.92 ( 111, s), 7.95 (HI, dd, el = 8.5 IIz, 2.1 Hz), 8.05 (211, d, J = 8.5 Hz), 8.22 (1H, cl, J = 2.1 Hz), 12.27 (lH,bs), 14.73 (HI, bs) G-3 Η Me H 1.07 (311, d, el = 6.6 Hz), 2.68 - 2.77 (2H, m), 2.94 - 3.03 (111, m), 7.39 (211, d, J = 8.5 IIz), 7.72 (1H, d, J = 8.5 Hz), 7.95 (1H, dd, J = 8.5 IIz, 2.2 Hz), 8.06 (2H, (I, J = 8.5 Hz), 8.21 (III, d, J = 2.2 Hz), 12.19 (lH,bs), 12.69(111, bs) G-4 Η Cl II 3.19 (III, (Id, J = 14.3 Hz, 8.2 Hz), IU2 (1H, eld, J ^ 14.3 Hz, 6.3 Hz), 4.83 (1Π, dd, J = 8.2 Hz, 6.3 Hz), 7.Ί8 (2H, d, J = 8.2 Hz), 7.72 (1H, d, Λ = 8.5 Hz), 7.92 (HI, s), 7.95 (III. dd, el = 8.5 Mz, 1.9 Hz), 8.08 (211, d J =8.2 Hz), 8.22 (Hi d, J = 1.9 Hz), 12.77(111,1)8), 13.4r3(lH,bs) G-5 II Cl Mo ：121 (111, (Id, t] = 14.3 IIz, 8.0 Hz), 3.41 (HI, dd, el = 14.3 Hz, 6.6 Mz), 3.77 (311, 8), ΑΑβ (III, dd, J = 8.0 I Iz, (U) I lz), 7.20 (ΠΙ, s), 7.26 (211, cl J = 8.5 IIz), 7,35 (III, d, J = 8.5 Hz), 7.52 (HI, (Id, J = 8.5 Hz, 2.2 Hz), 7.78 - 7.81 (311, m), 10.71 (1H, bs) (CDC13) G-6 II F M 3.11 - ：).3i) (211, m), 5.23 - 5.44 (111, m), TAG (2H, d, J = 8.2 Hz), 7.72 (HI, (1, J = 8.2 Iiz), 7.92 (ill, s), 7.95 (HI, (Id J = 8.2 ilz, 2.1 Hz), 8.09 (2ii, (1, el = 8.2 H/), 8.22 (1H, cl J = 2.1 H/), 13.45 (IIM)s) (58 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） I 裝--------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明) 表2 3 化合物 No. Ri° Ri R2 HR m-NJVIR (DMSO d-6) Π·7 C,P~ II K h：l 1.20 (ail, t, eJ =： 7.1 Hz), 3.14 - 3.39 (211, m), 4.17 (2H, q, J = 7.1 Hz), 5,36 - 5.5G (HI, m), 7.45 (211, d, J -Η,Γ> 11/), 7.72 (HI. cl, rl - 82 II/,), 7.S)2 (III, h), 7.!)5 (111, (Id, rl - 8.2 Hz, l.f) iIz), 8.08 (2fl, (I, J = 8.2 Hz), 8.22 (1H, cl, J = 1.9 Hz), 12.78 (1H, 1)8) G-8 c,p- Me Cl II l.3f) (311, cl, J = 7.1 IIz), 3.41 - 3.49 (111, m), 4.78 (111, d, J = 8.5 Hz), 7.52 (211, d, eJ = 8.5 IIz), 7.72 (III, d. el = 8.5 Hz), 7.92 (1H, s), 7.95 (III, dd, el = 8.5 IIz, 1.9 Hz), 8.09 (2H, d. J =H.2 11/), R22 (111· (1，J = U) 11/), 12.76(111, bs) (請先閱讀背面之注意事項再填寫本頁) 訂---------哔' 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 _ B7 五、發明說明（W) 表2 4
經濟部智慧財產局員工消費合作社印製 化合物 No. R10 ζ \ν R2 R5 UI-NMU(DMS() d-G) Η·1 众 Η 11 FA (CDCla) 10.10(bs, 1H), 8.06(s, 1H). 7.91((1, 1H, J = 8.0 Hz), 7.89((1 1H, ,1 = 2.0 Hz), 7.72(d, III, J = 8.0 Hz), 7.69(d, 1H, J = 16.0 IIz), 7.61(dd, III, J = 8.5, 2.0 IIz), 7.53(t, HI, J = 8.0 Hz), 7.43(d, 111, J = 8.5 Hz), 7.23(s, 1M), 6.51(d, HI. J = IG.O ll·/)，Ι··«)((1, 2Π· J = 70 Πζ), 1.35((. 311，J = 7.0 Hz) Η·2 Clf 众 II II Η 12.90(8, 1H), 12.50(s, 1H), 8.57(s, 1H), 8.23(d, 1H, J = 2.0 IIz), 8.10(d, 111, eJ = 8.0 Hz), 7.96(dcl III. J -8.5, 2.0 Hz), 7.94(s, 111), 7.92(cl 111, J = 8.0 Hz), 7.73(d, 1H, J = 8.0 Hz), 7.68(d, 1H, J = 16.0 Hz). 7.62(t, 1H, ef = 8.0 IIz), 6.76(d, 111. J = 16.0 Iiz) Η·3 Η 11 Μο 2.22 (：»1, s), 2.42 (3H, s). 3.85 (3M. s), 6.37 (III, d, J = 15.9 Hz), 7.10 (III, s), 7.18 (IH, s), 7.25 (III, s). 7.31 (III, d, J = 8.5 Ilz), 7.40 (1H. (Id, J = 8.5 Hz, 1.9 Hz), 7.63 (III, d, J = 1.9 Hz), 7.82 (1H, cl J = 15.9 Hz), 11.30 (HI. bs) (CDC13) Η·4 II π II 2.41 (GH, s), 6.55 (III，d, J = 15.9 H/), 7.53 (1H, s), 7.69 (1H, s), 7.72 (III, d,J = 8.4 Hz), 7.79(111, (LJ = 15.9 Hz), 7.73 (1H, dd, J = 8.4 IIz, 1.9 Πζ)，8.18 (III，d，J = 1.9 IIz). 12.70(111,8) Η-5 η C1 Ε! 1.42 (311, t, J = 6.9 Hz), 2.16 (3H, s)t 2.43 (311, s), 4.39 (q, 211, J = 6.9 Hz), 7.17 (1H, s), 7.19 (1H, s), 7.26 (III, s), 7.34 (1H, d, J = 8.7 Hz), 7.Ί5 (!H, dd, J = 8.7 Hz, 2.1 Hz). 7.47 (III, s), 7.69 (1H. d. J = 2.1 II/), 7.1)1 (111, s), 11.09 (III, s) (CDC13) ΙΙ-6 Μβχςβ II C1 II 2 M (Mil. s), 2.42 (；m, s), 7.50(111. s), 7.57(1H, s), 7.72(H L.d, J = 8.5 IIz), 7.91 - 7.94 (211, m), 8.04 (HI. s)t 8.18 (111, d, J = 1.9 Hz), 12.71 (UI,s) 70 (請先閱讀背面之注意事項再填寫本頁)
訂----- f 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 五、發明說明（π Α7 Β7 表2 5 化合物 No. Ri〇 z \v R2 RR t l l.NMR (DMSO d-6) n-7 h II Cl II 7.7；3(d, UI, J = 8.G Hz), 7.i)5(dd. IM, J = 8.(3, 1.8 Hz), 7.97(s, 1M). 8.03(s, 1H)，8.(Μ·8.10(ηι. 2H), 8.17«, HI, 7.7 11/,), 8 02(d. HI, J - l.H Jlz), l；).()l(s, III), l l.OiKs, HD 一 Η·8 F3c f ^!r H Cl II 7.55(1:, IH, J = 7.7 Hz), 7.78(m, 1H), 7.79(d, 1H, J = 2.7 IIz), 7.86(d. Ill, eJ = 4.5 Mz), 8.32(s. 1M), 8.35((1 111，J = 4.5 Hz), 8.39(t, 1H, J = 7.7 Πζ), l:U8(s, UI)，13.87(br, UI) —^---------裝--------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 71 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 五、發明說明（^) 表2 6
經濟部智慧財產局員工消費合作社印製 化合物 No. Ri° Y !{i R2 HR αΐ-NMK (I)MSO (l-fl) Ι·1 •NHCH2· II Mo El (CDCIa) 7.91(d, HI. J = 1.9 Ilz), 7.(57((1, HI, J = 1.3 Hz), 7.62(dd, 1H, J = 8.3, 1.9 Hz), 7.43(d, III, J = 8.3 II*), 7.41(s. 4H). 6.73(s, tH). 5.57(m, 1H), 4.57((1, 2H, J = 5.8 Hz), 4.27(q, 2H, J = 7.1 Hz), 2.1 l(cl mi, J = t.3 IIz), 1.35(1, ；Ul. e! = 7.1 Ilz) 1-2 c，^· -nhch2. 11 Mo H 12.50(bs, 1H), 8.29(t„ 1H, J = 5.5 Hz), 8.03(d, 1H, J = 2.0 Hz), 7.80(dd, 1H, J = 8.5，2.0 Hz), 7.6I(d, 1H, J = 8.5IIz), 7.57(s, III), 7.45(8, 4H), 7.30(s, 1H), 4.54(d. 2H. J = 5.5 Ilz), 2.02(d, 3H, J = 0.5 Hz) 1-3 c，^- .NHCOCH2- II Mo Et (CDCIa) 8.82(bs, 1H), 7.88(d, 1H, J = 2.0 Hz), 7.68(s, 1H), 7.58(dd, IH. J = 8.0, 2.0 Hz), 7.45(d, 2H, J = 8.2 Hz), 7.44(d, 1H, J= 8.5 Hz), 7.35(d. HI, J = 8.2 Hz), 7.15(s, 1H), 4.29(q, 2H, J = 7·0 Hz), 3.85(s, 2H)，2· 14((1, 3H, J = 1.4 Hz), 1.36(t, 3H, J = 7.0 Ilz) Ι·4 •NHCOCH2· H Me H 12.(M)(bs, 1H), 12.50(bs, IH), 8.l4(cl, III, J = 2.0 Hz), 7.88(cld, HI, eJ = 8.5, 2.0 Hz), 7.84(s, III), 7.70((1, IH, J = 8.5 Hz), 7.58(s, III). 7.45((1, 2H, J = 8.5 Hz), 7.40(cl, 2H. J = 8.5 flz>, 3.84(s, 211), 2.03((UUl· ,1= 1.5 I lz) Ι·5 -NHS〇2· H Mo Et (CI)CI3) 1.35(t, 311, J = 7.2 Hz), 2.00(d, 311, J = 1.5 Hz), 4.27(q, 211, J = 7.2 Hz), 6.64(s, IH), 7.35((W, 111, J = 8.2, 2.1 Hz), 7.42 (d. 2H, J =8.2 Hz), 7.44((1, 1H, J = 8.2 Hz), 7.58((1, ill, J = 2.1 Hz), 7.62(s, 1H). 7.98((1, 211, J = 8.2 Hz). 1-6 -NIISO2- II Mo U (C13C13+CD30D) 2.09(d, 311. J = 1.5 Hz), (166(8, IH), 7.40(dd, 1H, J =8.2, 2.4 Hz), 7.49 (cl, 211, J = 8.5 Ilz), 7.52(cl III, J = 8.2 Hz), 7.(H>(d. Ill, J = 2.4 Hz), 7.G9(s, III), 7.97((1, 211, J = 8.5 Hz). 72 (請先閱讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 71 五、發明說明（ 實施例3化合物（A-15 )之製造 cr
Ph3+P^C02Me
(請先閱讀背面之注意事項再填寫本頁) 將甲氧-甲氧羰甲基-氯化三苯鱗152mg及2-(4-甲醯 苄醯胺基）-4-(3,4_二氯苯基）吖唑57mg懸浮在二氯甲 烷3 ml，加三乙胺38mg,在室溫攪拌一夜後，減壓蒸除溶 劑，在矽膠柱層析，得化合物（A - 1 5 ) 3 0 m g，融点203〜205°C UI-NMR (CDCla) δ ppm: 3.85 (η, 311), 3.85) (8, ；ΠΙ), fi.OR (β, III), 7.22 (s. III). 7.46 (dd, 1Η, J = 8.2, 1.9 Hz), 7.(53 (d, MI, t] = 8.2 II/) 7.8Π (d, 211, J = 8.G Hz), 7.92 (d, III, J = 1.9 Hz), 7.5)^1 (d, 2!i, J = 8.(5 11/), 9.82 (brn, 1H). 實施例4化合物（)之製造 將（E) -3-(4-碘苯基）-2-甲基丙烯酸乙酯200mg、 二氯雙（三苯膦）鈀（Π) 22mg、2-胺基-4-(4’-氯苯基）-1H-咪唑277mg及三乙胺〇27ml溶在DMF 7ml,在CO 大氣下9 (TC攪拌1 5分而放冷後，注入水中，濾集結晶， 以D M F再結晶，得淡黃色結晶之化合物（J - 3 ) 經濟部智慧財產局員工消費合作社印製 1 1 7 m g ° 實施例5化合物（J -1 6 )之製造 將化合物（A - 5 3 )之乙酯3 0 0 m g溶在乙睛-四氫呋 喃（1:1) 80ml，加 1-氟-4-羥基-1，4-二吖雙環[2.2.2]辛 烷雙四氟硼酸鹽（50%在二氧化矽1 .24 g )，在80 °C攪 拌3 0分後，濾除二氧化矽，減壓蒸除溶劑，懸浮在氯仿， -73- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 72 五、發明說明（ 再濾除不溶物，減壓濃縮。在分取用TLC板精製，得黃 色結晶之氟化物20mg。將此仿化合物（A-2 )之製法 水解，得化合物（J-16)。 仿實施例4及5合成化合物（J-1 )〜（J-2 ) 、( J- 4)〜（J-15)及（J-17)。其物理常數如表27及 28 ° 請 先 閱 背 面 之 注 填从I裝 頁I I I I I I I訂
經濟部智慧財產局員工消費合作社印製 4 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 五、發明說明（Μ ) r< 2 7
經濟部智慧財產局員工消費合作社印製 化合物 No. X Ri R2 R5 VH-NMIi (DMSO d-G) J-1 HO II Cl K( (：H 1, t , el = 7.2 11/), 4.32 (2H. q, J = 7.2 ⑽，（U3 (111, s), 7.24 (111，t，J = 7.5 Hz), 7.46 (211, t, J = 8.1 IIz), 7.76 (211, d, J = 7.8 Hz), 7.98 - 8.12 (Γ3Π, m), 11.02 (III s), 11.89(111, s) J-2 HO II Cl II (J. 13 (HI, s), 7.24 (III, t, J = 7.2 Mz). 7.4G (211, t, J = 8.l Hz), 7.75(211, (I,J = 8.4 Π/), 7.90 - 8.12 (511, m), 11.01 (HI, s), U.8G (UI,s), 13.80(111, bs) J-3 H M(， lit 12.07(1)8, III), 11.74(1)8, III), 8.13((1 2H, J =8.5 Hz), 7.79((1, 2H, el = 8.5 Hz). 7.G7(s. Ill), 7.G：Kd, 211, J 8.5 Ilz), 7.44(s. III). 7.Ί0((1, 2H, J = 8.5 Hz), 4.22(q, 211. J = 7.0 M/), 2.09((1, 3II,ei= 1.2Hz), 1.29(1, 3H,J = 7.0 IIz) J-4 H Me 11 12.1()(bs, 3JI), 8.12((1, 2H, J = 8.5 Hz), 7.80((1, 2F1, J = 8.5 Hz), 7.65(s, 1H), 7.62(d. 211, J = 8.5 Hz), 7.45(s, III), 7.40(d, 2II, J =8.5 IIz), 2.07((1, 311, J = 1.5 Hz) J-5 H Me Et 14.00(bs, 1U), 12.20(ba, 1H), 8.10-8.20(m, 3Π), 7.95(dd, 1M, J = 8.2, 1.9 Hz), 7.77(d, 1U, J = 8.2 Hz), 7.60-7.70(m, 3ii). 4.23(q. 2Π，J = 7.0Hz), 2.10(s, 3H), 1.29(t，311, J = 7.0 Hz) J-6 H Mo 11 13.95(1)«, 111), 12.(5f)(bs, 111), 12.22(bs. Ill), 8.1〇.8.1H(m, ；Ul), 7.05((1(1, 111, J = 8.2, 2.0 II·/), 7.77((1 HI, J = 8.2 Hz). 7.61-7.G8(m, 311), 2.07((1, 311, J = 1.2 Hz) J-7 o-<^ H Me Et l；12/l(ba, HI), 8.20((1, 211, J = 8.2 Ilz). 7.96-8.(M(m, 211), 7.64-7.70(m, 3Π), 7.52-7,(50(m, 3H), 4.23((1, 2H, J 二 7.0 Hz)， 2.10((1, l)\l eJ = 1.4 Ilz), 1.29(t, 3H, J = 7.0 H/) J-8 II Mo lit l；l72(hs, III), 8.2().8.30(m, 4H), 7.66· 7.74(m, ：MI), 7.Γ)〇.7.58(ηι. 3il), 4.23(q. 2M. J = 7.0 Ilz), 2.1()(s, ：UI), l.；U)(t, 311, J = 7.0 Ilz) J-9 II Mo Id 1().5()(8, III), 8.0β((1, 211, J = 8.2 Hz). 7.79((1. 2!I, ,J = 7.1 II/), 7.G2.7.70(m, ；UI). 7.^l(t, 211, J ^ 7.5 Hz), 7.30(t, III, J = 7.Π ll·/)，G.74(s, 111), 2H，J = 7.1 丨Iz). ：l77(s, 3H), 2.09((1, 311, J= 1.1 Hz), 1.29(t. ：HI, J = 7.1 II/) -75- I裝---- (請先閱讀背面之注意事項再填寫本頁) 訂---------«_ 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 五、發明說明（# ) 表2 8 經濟部智慧財產局員工消費合作社印製 化合物 No. X \v R2 RR Ul-NMR (l)MSO d-G) J-10 HOOC Π Mo II 12.(H(bs, HI), 7.99(d, 2H, J = 8.2 Hz), 7.72((1, 211, J = 8.5 Hz), 7.6G(s. tH). 7.28· 7.：Wm, ΠΙΙ), Γ,!)5(η, 111). 2 07((1, .f 1.2 11/) J-11 n c\ H 2.；M (311, (1, J = U) Jlz), 7.18 - 7.2^1 (III, m), 7.35 - 7.42 (1H, m), 7.56 - 7.64 (1H, m), 8.03 (211, (1, J 8.F3 Hz), 8.04 (III, s), 8.18 (2!I,d, J = 8.5 Hz), 12.79 (UU)s) J-12 F3Hif II c\ II 2.,15 (311, (1, r! = 1.G Hz), 7.51 - 7.56 (IH, m), 7.84 - 7.Π2 (1H, m), 8.03 (211, d, J = 8.Γ. llz), 8.04 (HI, h), 8.U) (211, d, J = 8.5 Hz), 12.83 (III, s), 13.84 (lll,bs) J-13 Br Me II Cl II 2.M (：il 1, s), ΊΛΑ (11U , el - 7.9 1 Iz), 7.Γι5 -7.59 (III, m), 7.69 - 7.72 (1Π, m), 7.92 (111, t, eJ = 1.8 Uz), 8.02 (211 d, J = 8.5 IIz), 8.04 (1H, s), 8.19 (2Π, (I, J = 8.5 IIz), 12.70 (III. b«), 13.80(111, bs) J-14 F3C Me li Cl 11 2.50 (311, s), 7.72 - 7.74 (211, m), 8.00 - 8.0G (Γ)!Ι, m), 8.20 (211, d, J = 8.5 IIz), 12.77 (III, r), 13.75 (III, bs) J-15 ςά8 n-Pe 门 II Cl II 0.86 - O.iK) (311, m), 1.33 - 1.35 (4H, m). 1.48 - 1.58 (211, m),. 2.64 (2H, t, J = 7.5 Hz), 2.98 (4H, r), 7.07 - 7.09 (1H, m), 7.20 (III, i, J = 7.6 Hz), 7.63 - 7.66 (1H, m). 8.03 (2Π, (1, J = 8.5 Hz), 8.05 (1H, s), 8.20 (2H. (1, J = 8.5ilz), 12.81 (III, s), 13.79 (lll.bs) J-16 n-Bu F II C! II 13.80(1)8, 111), 13.20(8, III), 8.20((1, 211, J = 8.5 Hz), 8.0G(r. Ill), 8.04(cl 2Π, J = 8.0 Hz), 7.75(m, III), 7.08(m, 111), 7.42((1(1. Ill, J = 8.2, 7.(ί 7.2G(d，1ΙΓ J = 7.G llz), 21!, J - 7.8 IIz), 1.50-1.70(m. 211), 1.2().!.4()(m, 211), 0.92(t, 311, J = 7.3 IIz) J'17 Q-^t f3c F - H C! H I3.88(1)r, 1Π), 13.01(s, 1H), 8.l0-8.24(m. 411), 8.0Q.8.08(m, 3H), 7.74-7.80(m, 2H) —7 6— 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 29牙公釐） -----------裝--------訂---------AW. (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 75 五、發明說明（ 實施例6化合物（K-14，15，18)之製造
11 第2工稽
Η 第5工《 第4工獾
Κ-14
(請先閱讀背面之注意事項再填寫本頁)
裝 經濟部智慧財產局員工消費合作社印製 (第1工程） 將化合物（1 1 ) l.lg、（ 1 2 ) 760mg、肆三苯膦鈀 2 5 0 m g溶在D M F，在1 1 0 °C攪拌2小時後，注入乙酸乙 酯中，水洗4次，以飽和食鹽水洗淨，以硫酸鎂乾燥，減壓 蒸除溶劑，在矽膠柱層析（乙酸乙酯：正己烷= 2:3 )，得 化合物（13 )，非晶質8 70mg。 NMR(CDC13, δ ppm); 4·06 (3H, 8), 7·16 (1H, 8), 7.28 · 7.50 (10H, m), 7.72 (1H， dd，J = 4.8 Hz，1·8 Hz), 7·75 · 7·80 (2H, m), 8·25 · 8.30 (2H, m), 8.40 (1H, d，J = 2.1Hz). (第2工程） 將化合物（1 3 ) 8 7 0 m g溶在甲酸（9 8〜1 0 0 %，2 0 m 1)， 在5 0 °C攪拌3小時後，減壓蒸除溶劑，加甲苯而再濃縮， 在異丙醚濾集，得化合物（4 )，白色結晶473 mg。 -77- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐）
•I I ϋ I 一 ^^ 1 n 1 1 I 1284639 A7 B7 五、發明說明（76) iH NMR(CDCla, δ ppm): 3.93 (3H, β), 7.97 · 8.02 (2Η, m), 8.04 (1Η, dd, J = 7.8 Hz, 1.8 Hz), 8.07 - 8.12 (2H, m), 8.36 (1H, d, J « 1.5 Hz), 8.82 (1H, d, J = 4.8 Hz). (第3工程） 化合物（K-14 )以化合物（4 )爲原料，仿實施例1-第4工程反應來合成。其物理常數如表29。 (第4工程） 化合物（K-15 )以化合物（K-14 )爲原料，仿實施例 1-第5工程反應來合成。其物理常數如表29。 (第5工程） 將化合物（K-15) lOOmg、二苯磷醯疊氮55//1、三 乙胺351//1及第三丁醇lml溶在DMF(15ml)，在100°C 攬拌1小時後，注入乙酸乙酯中（析出時添加THF )， 水洗2次，以碳酸氫鈉水溶液及飽和食鹽水洗淨，以硫 酸鎂乾燥，減壓蒸除溶劑，在矽膠柱層析（乙酸乙酯：正 己烷=1:1)，得化合物（K-18)，白色結晶60mg。其物 理常數如表2 9。 仿實施例6合成化合物（K-16 )〜（K-17 )及（K-19 )。仿實施例1合成化合物（K-1 )〜（K-1 3 )。其 物理常數如表2 9〜3 1。 請 先 閱 讀 背 面 之 注
重裝 頁 I I訂
經濟部智慧財產局員工消費合作社印製 -78- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 五、發明說明（^ ) 表2 9
經濟部智慧財產局員工消費合作社印製 化合物 No. Ri° Y W UI-NMR (DMSO d-G) Κ·1 Η Ο -(Χ)ΝΗΜο 2.80 (:511, d, J = 4.5 Hz), 7.()() (HI, cleJ= 15.8 Hz), 7.70- 7.81 (4H, m), 7.89 - 7.93 (All, m),. 8.1G (Π1, (I, J = 2.0 Hz), 8.5：3 (HI, q, .I - 4.5 Hz). 12.02 (1H. b.s) Κ·2 F Η Ο -ΟΟΝΙΙΜο 2.81 (；»l, d,eJ = 4.4 Hz), 7.02(111, (1, J = 15.8 Hz), 7.47 - 7.56 (ΠΙ. m), 7.71 - 7.81 (511, m),. 7.90 - 7.i)7 (iUI, m), 8·!Μ (UI，q, J = II/), 12.60(111, bs) Κ-3 Η •COOMo 3.88 (：Vf I, r), 7.03 (III, cl J = 15.9 Hz), 7.71 (HI, d, J = 8.2 Hz), 7.76 - 7.83 (3H, m), 7.89 - 7.92 (2JI, m),· 8·()··3 (2H, (1, J = 8.2 ilz), 8.15 (111, (1, J = 1.8 Hz), 12.66 (III, bs) Κ-4 Η Me Ο -CONIIMo 2.17 (3H, d, J = 1.1 Hz). 2.80 (：ill,d,el = 4.5nz),7.58 (211, dJ =8.3 Πζ), 7.(52 (111, l)s), 7.72 (III, d, J = 8.4 Π/).. 7.89 - 7.95 (411，m)，8.2() (UUUJ = 2.0Π/)， 8.53 (1H, q, J = 4.5 Hz), 12.46 (HI, bs) Κ-5 Η F 0 -CONIIMo 2.79 (3H,d,eI = 4.5IIz), 7.1β(ΠΙ. (I, Λ = 24.2 Uz), 7.64 (2H, d J = 8.311/), 7.71 (III, d. J = 8.5 II/).. 7.81 - 7.88 (m, 2H), 7.90 - 7.97 (m, 211)，8.18 = 1.7 8/1?) (HI, q, J = 4.5 IIz), 13.01 (III, bs) Κ-6 Η 0 -coon 7.11 (111, d, J = 15.8 llz). 7.09 -7.82 (411, m), 7.89 - 7.93 (2H, m),. 8.02 (2H,d, J = 8.l Hz), 8.16 (III (1, J = 1.6 Hz), 12.72 (1H. bs) Κ-7 C，P~ Η ο -COOMo 2.51) (2IU, J = 7.5Hz). 3.04 (2H. U el = 7.5 Hz), 3.91 (311, s), 7.11 · 7.l7(；llLm), 7.4,1 (2H.d. J = 8.7 Hz), 7.58(111,(1(1 J = 8.7 IIz.2.0 11/), 7.87 (1H, (1, J = 2.0 Hz), 7.JH (211, (1 J = 8.7 IIz),. 9.87 (lll,s) (CDCUl) -79- (請先閱讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 29/公釐） 1284639 A7 五、發明說明（W ) ^^_B7 經濟部智慧財產局員工消費合作社印製 表3 Ο 也合物 No. c»-^~ W UI-NMil (DMSO (1-(5) K-8 r- .(XK)ll 2.82 (2M, t, J = 7.2 Hz), 3.02 (211, U J = 7.211/), 7.88 (2U. d. J = 8.5 11/), 7.IIH (III, (1, J 8 ! Il/V 7.83-7.89 (ΊΙΙ,ιη),8.12(111,(U =2.0 Hz),. 12.；3：3 (III, s), 12.82 (1Π, s) Κ·9 -S( )2N11(t-Hu) (COC\：\) 1.26(s, 911), 2.25((1 el = 1.5 Hz), 4.61(s, III). 7.21(s, 1H), 7.45(d, 211, J = 8.5 Mz), 7.47((1, 1U e! = 8.2 Mz), 7.00(brs. Ill), 7.卿(1，ltl, J = 8.2，1.8 11/), 7.fM(d, HI. J - 1.8 U/). 7.5)5((1, 2U, tl = 8.Γ) Hz), !).58(brs, 111). Κ·10 .SO2NH2 2.14((1, 3Ht J = 1.5 Ilz), 7.42(brs, 2H), 7.59(brs, HI), 7.65((1, 211, J =8.2 liz), 7.69(d, III, J = 8.2 Hz), 7.86(s, UI), 7.87((1, 2M, J -8.2 Hz), 7.91(dd, 111, J = 8.2, 2. t Il«\ Q ΙΟΛΙ 11T T — Ο t ΙΛ^\ ΙΙΛ)% Ο· ΙΟ^Ιι, III, t) 一 L·. 1 I 17s)9 12.47(brs, III). Κ·11 α分 Γ- •SOaNIKt-Bu) 1.1 t(s, ?)H), 7.03((1, 1H, J = 16.2 II/), 7.R5(r, III), 7.67((1 til, J = 8.5 llz), 7,80(d, III, J = 1G.2 Hz). 7.81((1, 2U, el = 8.5 Hz), 7.89-7.9；Kni, ΊΗ), 8.17((1 111, J = 1.8 Hz), 12.67(8, 111). Κ·12 .SO2NII2 7.0；K(J, HI, J = 16.0 Hz). 7.47(211, s), 7.72(d, 1H, J = 8.5 Hz), 7.8l(d, III, J = 1G.0 Hz), 7.83((1, 2M, J = 8.4 Hz), 7.89((1 2H, J = 8.4 Hz), 7.91(s, 1H), 7.f)l((lcl III, J = 8.5, 2.1 Hz), 8.17((1, 211, J = 2.1 Hz), 12.67(s. --- 1H). Κ-13 c丨分 H O •Sihll 0.{M((l, III J = 15.8 Hz), 7.60((1, 2H，J = 8.2 Hz), 7.67(d, 2H, J = 8.2 Hz), 7.72((1, 1H, J = 8.2 Mz). 7.74((1, 1H, J= 15.8 Hz). 7.8i)(s, HI), 7.91((ld, III, J = 8.2, 1.9 Ifz), 8.1(5((1, 1IL J = 1.9 Hz). 12.n7(brs, III). Κ-14 •NIICO. ^^COOMe 3.f)4 (；lll s), 7.72 (111, d, J = 8.7 Mz), 7.93(111, s), 7.95(111. (Id. J = 8.Ί11τ:, 1,8 11/),8.04-8. !()(；« I, m), 8.22(111, (1,,1 = 2.4 11/). 8.；K) (2Jlfd, el = 8.4 Hz). 8.39 (HI. d,J =1.2 Hz), 12.93(111, s) Κ-1Γ) -NIICO. ^^COOH 7.71 (111, (I, J = 8.4 Hz), 7.82 (ΙΙΙ,Μ，7.8ί)(1ΙΙ, s), 1A)：)-Ri)\ CMI.m), 8.22(111,(1. J = 2.1 II/). 8.2(5-8.；H (；MI, m), 8.G5 (III. bs) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297P公釐） -80- --------! 裝--------^ -------—^^_w (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 Δ7 Α7 ______ Β7 化合物 No. Ri() Υ W UI-NMR (I)MSO (U?) K-1G -N1ICO· >"^^OCH2OMe 3.53 (3H, s), 5.2(? (s, 111), 7.10 (111, (1(1(1, J = 8.2 Hz, 2.5 H/. 09 II/), 7.21(111, s), 7.22-7.28 (2H. m), 7.36 - 7.40 (211, m), 7.55 (lH, (1(1,4 = 8./1 11/, 2.0 Hz). 7.ΠΜ (2ΪΙ. …8.4 llz), (1. J 2.()11/), ΊΜ (211,(1,.1 = 8.4 Hz), 10.8G (Ul bs) (CDC13) K-17 -NIICO· 6.82 - 6.86(1H, m), 7.12 - 7.13 (III, m), 7.17-7.20(111, m), 7.28 -7.37 (Hi, m), 7.73 (1H. d, J = 8.2 Mz), 7.89 (2ΓΙ, d, J = 8.5 Hz), 7.93 (1H, s), 7.95 (HI, ddJ-8.2 Hz, 2.0 Hz), 8.21 (2H, cl J = 8.5 H/), 8.23 (III, (1, J = 2.0 II/), 9.02 (111,8), 12.83 (Uls) K-18 •NHCO· 从2 G.OG (2H, s), 6.79 (111, s), 6.87 (HI, d, J = 4.8Hz), 7.73(111, d.J =8.4 Hz), 7.82 (2H, d, J = 8.4 Uz), 7.93 (HI, s), 7.96 (III, dd, J = 8.1 Hz, 1.5 FIz), 8.02 (III, cl, J = 5.1 Hz), 8.21 - 8.27 (3H, m), 12.88(111,8) K-19 -NHCO· ^^NHS02Me 3.06 (2H, 8), 7.28 (1H, dt, 7.2 Hz, 2.1 Hz), 7.45 - 7.57 (3H, m), 7.73 (m,d,J = 8.1Hz), 7.8l(2H, (1 J = 8.4 11^), 7.93(111, s), 7.96(111. (Id, J = 8.4 Hz, 2.1 IIz), 8.21 · 8.27 (：iH, m), 9.88(111, bs), 12.84 (III, bs) (請先閱讀背面之注意事項再填寫本頁) 裝--------訂— # 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） Ϊ284639 A7 B7 ^、發明說明（8〇 ) 實施例7化合物（L - 1，L -2 )之製造 __P 第1工程
»4工稽 第3工《
閲 讀 背 面 之 注
(第1工程） 將化合物（15) 6.3g、（ 16) 2.0ml、三乙胺 6.3ml、肆三苯膦鈀870mg及碘化銅（1) 290mg溶在 D M F ( 7 0 m 1)，在9 0 °C攪拌4小時後，注入乙酸乙酯中，水 洗4次，以飽和食鹽水洗淨，以硫酸鎂乾燥，減壓蒸除溶 劑，在矽膠柱層析（乙酸乙酯：正己烷=1 : 4 )，得化合物 (17 )，非晶質 2.25g。 】H NMK(CDC[3, δρριη): 3.81 (3Π, η), 7·(川（Itl, 8)，7·2Η·7·42(Γ>1Ι，τη)，7·51 - 7.55 (4H, m), 7.85 (2H, d, J = 8.7 IIz), 8,17 (211, d, J = 8.7 Hz). (第2工程） 將化合物（17) 18〇mg溶在甲酸（98〜100%，4mL)及 THF ( 4ml )，在室溫攪拌1 8小時後，減壓蒸除溶劑，加1 甲苯而再濃縮，在異丙醚濾集，得化合物（18 )，白色針 -82- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 裝 I I I I I 訂 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、發明說明（ 81 晶 95mg。 m NMR(CDCla, δ ppm): 3.80 (3H, s), 7.79 (2H, d, J = 8.1 Hz), 8.00 (2H, d, J = 8.1 Hz), 13.33 (1H, be). (第3工程） 化合物（L-l )以化合物（4 )爲原料，仿實施例1-第 4工程反應來合成。其物理常數如表3 2。 (第4工程） 化合物（L-2 )以化合物（L-1 )爲原料，仿實施例1-第5工程反應來合成。其物理常數如表3 2。 仿實施例7合成化合物（L-3 )〜（L-4 )。其物理 常數如表3 2。 請 先 閱 讀 背 面 之 注 3 填 % 本 頁
裝 I訂
經濟部智慧財產局員工消費合作社印製 3 8 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 五、發明說明（心） 表3 2
化合物 No. Ri〇 Z UI-NMR (DMSOd.f)) L-1 ~〇~ Mo 3.82 则，s)，7.72 (1H, s), 7.85 (2H, (1，J = 8.7 Hz), 7.iM (111, (Id J = 8.4 Hz, 2.1 Hz). 7.iH (111, 8), 8.1G - 8.22 (3II, m), 12.97 (HI, s) L-2 -Or II 7.72 (HI, (1, J = HA Hz), 7.81 (2H, d, J = HA Hz), 71)5 (111, dd, J = 8.4 Hz. 2.1 Hz). 7,ίΜ (III, h), 8.18 (211, d, fJ = 8.4 11/), 8.21 (III, (1, J = 2.1 Hz), 12.90(1 Π, s) L-3 ΟΜθ Mo a.8〇 〇m, r), 4.01 (3H, b), 7.70 - 7.74 (3ii. m), 7.88 (III, r), 7.92 · 7.96 (2H, m), 8.21 (III, (1, J=1.8 1Iz), 12.99(111, s) L-4 (ΟΜβ 11 4.01 (：3II, r), 7.70 - 7.74 (311, m). 7.88 (HI, r), 7.93 - 7.97 (211, m), 8.22 (Hi. d. J =2.1 Hz), 12.98 (HI, s), 13.75 (III. bs) -----------裝--------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 84 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 _ B7_五、發明說明t G > 仿以上方法反應，合成下列化合物。 〇Η Ν ί化合物 No.，R«，Rb, Rs Rd, = (Μ·1· 11,11，Π, Π, Η), (Μ·2, Η, II, Η, Π· Cl)， (Μ-3, II, II, II, II, F), (Μ-4, II, II, II, II, (ΜΛμ), (Μ-5, II, II, II, H, Hr), (Μ-(5. II. Η. II. II. CH：〇, (Μ-7, Η, II, II, Ρ, II), (Μ.8, II, H, II, ΙΛ (Ί), (Μ-ί). II, 11, H. F. Ρ). (Μ-10. H, Η, II, F, CF；3), (Μ-11, II, Η, II, ΙΛ Hr), (Μ-12, II, It, II, ΙΛ (ΊΙ：0. (Μ- 13. Η, II, Η, Cl, II), (Μ-14, MoO, II, II, Cl, C!), (Μ-15, II, Η, Η, Cl, F), (M-1G. II, Η. II. Cl, CFs), (Μ-17, Η, II, II, Cl, Hr), (Μ-18, II, II, II, Cl, Clin), (Μ-19, Η. Η. Η. Clio. H), (Μ-20, II, Η, II, CHn, Cl), (Μ-21, II, Π, Η, CMa, F), (Μ-22, H, Π. H. CII.3. CF.i), (Μ-23, II, II, II, CHn, Hr), (Μ-24, Η, II, II, CHm, ClI；〇, (Μ-2Γ>, H. Η. II. Et. Η), (Μ-26, II, Η, Η, Et, Cl), (Μ-27, 11, Η, II, lit, F), (Μ-28, Η, II, II Et, CF；0, (Μ-29, Η, Η, Η, Et, Br), (Μ-30, II, Ιί, II, Et, CH；〇, (Μ-31, H, II, Η, n-Pr. Η), (Μ-32, 11, Η, II, n-Pr, Cl), (Μ-33, 11, Η, II, n-Pr, Κ), (Μ-34, 11, Η, 11, n-Pr, CF：〇, (Μ-35, Η, Μ, II, n-Pr, Br), (Μ-：Κ), II, II, II, n-Pr, Clin), (Μ-37, H, II, Η, oPr. Η). (Μ-38, II, Η, Η, c-Pr, Cl), II, Η, II, c-Pr, l〇, (Μ-^ΙΟ, Η, II, II, c-Pr. CF；0. (Μ-41, Η, Η, U, c-Pr, Br), (Μ-42, II, II, II, c-Pr, Clin), (Μ-43, 11, II, II, i-Pr, Η). (Μ-44, H, II, II, i-Pr, Cl), (M-45, [|, II, II, i-Pr, K), (Μ-Ί(5, II, II, II, i-Pr, CR〇. (M-47, II, Η, II, i-Fr, Br), (M^8, II, H, H, i-Pr, CII；〇, II, Η, H, n-Hu, ID. (M-50. Η, II. II, n-Bu, Cl), (M-51, !i, II, II, n-Hu, l〇, (M-52, II, II, II, n-Hu, CF：〇. II, H, H, n-Βυ, Br), (Μ-Γ)4, II, II, II, n-Hu, CII：»), (Μ-Γ)Γ), H, II, H, i-Hu, ID, (Μ-5Γ,? II, Η, H, i-Βυ, Cl), (Μ-Γ>7, II, II, II, i-Hu, l〇. (M-G8, IL II, II, i-Hu. CF：0. (M-59, Η, Η, II, i-Fiu, Br), II II, II, i-IUi, CII；〇, (Μ-(Π, II, II. II. sor-Hu. 85
丨丨！ ------％裝 (請先閱讀背面之注意事項再填寫本頁) 訂---------%_ 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 _B7_ 五、發明說明（私） II). iM-G2? Η, II, II, roc-Bu, Cl), (M-fiM, II, Π, II, sooHu, P), (M-G4, II. II. II. soc-Βυ, CF：3), (M-65, II, II, H, soc-Bu, Hr), II, II, II, soc-Hu, CH；〇. II. II. II. n-Fon, II), (M-68, II, II, II, CA)t (Μ-(ϋ), II, U, II, n-Pon, F), (M-70, (請先閱讀背面之注意事項再填寫本頁) Η. II, II. n-Pen, CF3), (M-71, Μ, II, II, n-i^on, Br), (M-72, Η, Η, II, π-Pen. CII3). (M-7：}, H, II, il, c-Fon, II), II, II, II, v^Vvi\t Cl), (Μ-7Γ), II, li, II, c l'oii, l·1), (M-76, II, Π, II, c-Pen, CFh), (M-77, II, II, II, c-Fon, Hr), (M-78, H, Η. II, c-Pon, CU：〇, (Μ-7ί), H, II, II, n-Hox, Π), (M-80, II, II, H, n-llox, Cl), (M-81, 11. II. H. n-Hex, P)? (M-82, Π, Η, II, n-IIox, CK；〇, II, II, II, n-!lox, l^r), (M-81. H. II. 經濟部智慧財產局員工消費合作社印製 H. n-Hox? CII3), (M-85, II, II, II, ollox, M), (M-HG, II, II, II, ollox. Cl). (M-87, H. II. II, c-Hex, F), (M-88, II, II, II, ollox, CKm), (Μ-8ί), II, II, II, c-IIox, Hr), (M-90. II, H, H, c-Hex, CHr〇, (M-5)l, Η, II, !I, Oil, II), (M-92, H, II, 11, OH, Cl). (M-93. II, Uf H, Oil, F), (M-94, II, II, II, Oil, CKn), (Μ-5)Γ), II, II, II, OH, Hr). (M-9G, II, II, II, Oil, CII〇, (Μ-Π7, II, II, II, Kt(), II), (Μ-ί)8, II, II. II. KlO. Cl). (M-99. Η, II, H, EtO, F), (M-lOO, II, H, II, hltO, CF；〇, (M-101, II, II, II, EtO, Br), (M-102, Η, II, H, EtO, CM,〇, (M-IOM, II, II, II, n-Pr(), II), (M-104, II. Π, Π, n-PrO. Ci), (M-105, Η, Η, II, n-PrO, l·1), (M-IOG, II, II, II, n-PrO, CT；〇. (M-107, II. IL II. n-PrO, Hr), (M-108, Η, II, II, n-Pr(), CII；〇, (M-10!), II, II, II, PhO, H). fM-110. H, Η, H, PhO, Cl), (M-111, Η, II, II, NiO, K), (M-112, II. Π. II. VhO. CF：〇, (M-113, Η, II, H, PhO, Hr), (Μ-Πτί, II, II, II, IMiO, CII；〇, (Μ-11Γ), Η, II. H. BnO. II), (M-116, II, II, II, BnO, Cl), (M-117, II, II, H, Hn(), l〇, (M-118, II, Η. H, BnO. CFa), (M-119, Η, Η, II, BnO, Hr), (M-120, II, II, il, BnO, CII；〇, (M-121. H. Η. H, PhCH2CIl2〇, H), (M-122, II, II, II, Ph(^II2CII2〇, Cl), (M-123, II, Π, II. PhCH2CIl2〇, F), (M-124, II, II, II, IM1CII2CII2O, CF；〇, (M-125. II, Π, H. Fh(；H2CIl2〇, Br), (M-12G, II, il, II, IMiCI[〇CIl〇(), C!I；〇, (M-127, H. II, 1L H), fM-128, H, H, II, CF：i(), Cl), (Μ-Ι2ί), II, II, II, 0K：i(), l〇, (M-130. H. H. H. CF3O. CF；〇, (M-131, Η, II, il, CKmO, Hr), (M-l；52, II, II, II, Cl^O, CII：〇, 8(； 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（K ) II. Π. Π，I)h，II)，（Μ-1·Ή，II，II’ II，I士，（Ί), (Μ·1:】Γ)，II，H，II, 1士，ία (M-ι;川，II. Η. H. Ph, CF3), (Μ-137, Η, Η, II, Ph, Hr), (M-138, II, II, II, IMi, CII；〇, (Μ-1：3ί), H. IL H, 4-F.Ph. Η), (M-140, Η, II, II, 4-F-IMi, Cl), (M-Hl, II, H, II, 4-Κ-Γ1ι, F). (M-142, Η, Η, H, 4-F-Ph, CPn), (M-143, II, II, H, ^K-Ph, Hr), (M-144, II, H, II. 4-F-Hi, CII：〇, (M-145, il, II, II, 4.(：Κ,νΙΜι, II), (Μ-Ι Κί, II, II, il, (Μ), (M-147, U, Η, H, 4-CF3.Ph, F), (M-M8, II, II, II, CFa), (M-149, Η. H. II, 4-CF3.Fh, Br), (M-150, H, II, II, 4.〇ΙΛμ-Ρ1ι, ClI；〇, (M-151, II, H, H, 4-(Me)2N.Ph, II), (M-152, II, H, II, 4-(Mo)2N-[Mi, Cl), (M-IT)：}, Π, Η. Π, 4-(Me)2N-Ph, F), (M-154, II, II, II, 4-(Mo)2N-Ph, CF：〇, (Μ-15Γ), II, II, II. 4-(Me)2N-Ph, Br), (M-156, II, II, Μ, 4-(Μο)2Ν-ΙΜι, ClI；〇, (M-157, Η, Μ, II, 4-011-Ph. Η), (M-158, Η, Η, H, 4-OH-lMi, Cl), (Μ-1Γ)ί), N, II, II, 4.〇II-Ph, F), (M-1G0. II, Η, H, 4-OH-Ph, CF3), (Μ-ΗΠ, II, II, II, 4.()iMMi, Hr), (M-162, II, Η, II, 4-OH-Ph, CII3), (M-163, II, II, Η, ：ΙΊ.(1ί.Κ.ΡΙι, Η), (M-KM, II, Η. II, ；i.4-cli-F-Ph. Cl), (M-165, Η, Η, H, 3,4-di.F.Ph, P), (M-16G, H, Η, M, 3,4-di-F.Ph, CF；〇, (M-167, 11，H，H，3,4-di-F-Ph, Br)，（Μ·1β8, Π，H，II，CII3)，（M-1G9· II， H, II, 4.C00H-Ph, Η), (M-170, II, H, ll d-COOH-Ph, Cl), (M-171, II, H, II, 4-COOH-Ph, F), (M-172, II, II, H, ^-COOlI-Ph, ΟΙΛ·〇, (M-173, H, Η, II, 4-COOH-Ph, Br), (M-174, II, H, II, ^-COOIl-IMi, Clla), (Μ-Ι7Γ), Η, II, II, Bn, II). (M-17G. H, H. ll Bn, Cl), (M-177, II, M, H, Hn, F), (M-178, II, Η, II, Hn, CF3), (M-179, H. Η. H, Bn, Br), (M-180, Η, II, ΓΙ, Bn, C1JI：〇, (M-181, II, H, II, 4-F-Bn, II), (M-182, ll ll M, 4.F.Bn, Cl), (M-183, II, li, II, Ί-Ρ-Ηη, K), (M*184, H, ll, II, 4-F-Hn. CF.3), (M-185, Η, Η, II, 4-F-Hn, Hr), (M-I8(), II, II, II, 4-Κ-Ηη, CH；〇, (M-187, H, IL ll, 2-Py, II), (M-188, Π, II, II, 2-Py，(Μ-18ί), II, II, II, 2-Py, F), (M-H)O, II. Η. II, 2-Py, CF.3), (M-191, II, II, II, 2-Py. 1^), (Μ-1ί)2, II, 11, II. 2-Py, CH；〇. (M-193. Η, Η, H, 3-Py, K), (M-l!)4, II, il, H, IJ-Py. Cl), (Μ-ΙΠΓ), Η, Η, H. ：M>, F). (M-19G. II, II, II, 3-Py, CF：〇, (Μ.1Π7, II, If, il, Hr), (M-198. H, U. II, 3-Py, 87 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ------------裝---- (請先閱讀背面之注意事項再填寫本頁) 訂--------- # 1284639 經濟部智慧財產局員工消費合作社印製 A7 __B7_ 五、發明說明（& ) (；ΙΙ：〇, (Μ-1ί)ί), Π, Μ, If, II), (Μ.200, li, II, H, Ί-Py, Cl). (M-201, II. II. II. 4-Py, F), (M-202, Η, Η, H, 4-Py, CK：〇, (M.20；i, II, H, H, 4-Py, Br), (M-204, II, II. H. 4-Py, CII.3), (M-205, Η, II, H, 2-Th, M), (M-20G, II, Π, H, 2-Th, Cl), (M-207. H, Η. H, 2-Th, F), (M-208, Η, II, H, 2-Th, CPn), (M-209, II, II, H, 2-Th, Br), (M-210. JI. H. II, 2-Th, Cli.i), (M-211, II, II, II, ：{-Τ!ι, II), (M-212, 11, II, 11, ；{.ΊΊι, (M), (M-213, II, Η, H, 3-Th, F), (M-214, H, II, II, 3-Th, CR〇, (M-215, Η, Η. H. 3-Th. Br), (M-21G, Η, II, II, 3-Th, CM；〇, (M-217, Π, II, H, Pit ^ -2-¾^ Η), (M-218, H, II, H,吡唑-2-基，Cl), (M_219, H, U，H,吡唑-2-基，F), (Μ·220. II, 11, 11， 吡唑-2-基，CF：〇,（Μ·221，丨1，H,丨丨，吡唑-2-基，Br)，（Μ·222,丨丨，丨丨，11, 壯唑-2-基，CH3), (M-223, II，Η,丨1，吡唑-3-棊，Η), (Μ·224, H，H，Η, 吡唑-3-基，Cl), (Μ·225, Η，Η, 11,吡唑-3-基，p)· (M.22G，Η, II，Η， 吡唑-3-基，CF3), (Μ·227, Η, 11, 1Ι·吡唑·3-基· Br), (Μ-228, II，Η, II， 吡唑-3-基，CH3)，（Μ-229, II，Η, Η,嘧啶-2-S，II)，（Μ·23(), Η, Η,丨【， 嘧啶-2-基，Cl), (Μ·231, Η，Η, II, _ 啶-2-基，Ι〇, (Μ·232, II，II，II， 嘧啶-2-基，CF3), (Μ-233, 1UI,丨1，嘧啶-2-基，Br), (Μ·234, Η，II，Η, 嘧啶-2-基，Clh), (Μ-23Γ), 11, II, Η,嘧啶·4-基，11)，（Μ·23(;，Π，Η, Η, 嘧啶-4-基，C1)，（Μ_237,丨丨，丨1，丨I，嘧啶-4-基，l·》，（Μ·238, 1 丨，11, 11， 嘧啶-4-基，CF3), (Μ·2·3ί), Π，1UI,嘧啶-4-基，Br)，（Μ-240, 11，II，Π· 嘧啶-4-基，Clh)，（Μ-241,丨丨，丨丨，Η,嘧啶-5-基，丨1)，（Μ·242, 11，丨1，Π， 嘧啶-5-基，α)，（Μ·2仏 Η，Η，丨I，嘧啶-5-基，Ι〇，（Μ·244，ΙΙ,Ι[,ΙΙ， 嘧啶-5-基，CF3), (Μ:24Γ),丨丨，|丨，丨丨，嘧啶-5-基，Br), (Μ·24β, Η, 1丨，Η， 嘧啶·5·基，Clh), (Μ-247, Η，II, II，ll()()(〕(〕ll2(〕lh(nh，11)，（M-248, llj HOOCCH2CH2CH2, Cl), (Μ-249, Η, II, II, II()OC(MI2CH2CIΙ2, F), (Μ-250, Η, Η. 11. HOOCCII2CH2CH2, CFa), (M.251, II, Η, II, I[OOCCIbClhCHs, Hr), (Μ-252. Η. H. Η. HOOCCH2CH2CH2, CHm), (Μ-25：], II, II, II, iIOOCCHoCHsCHoCHo, Η). (Μ-254, II, II, II, HOOCCII2CII2CII2CU2, CI), (Μ-2Γ)Γ>, Π, II, II, 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ~裝---- (請先閱讀背面之注意事項再填寫本頁) - Φ 經濟部智慧財產局員工消費合作社印製 1284639 A7 ____B7__ 五、發明說明（W ) HOOCClfsClhCIhCIh, F), (M-25G, II, II, II, ΙΙ()()ΟΟΙΐ2〇1Ι2〇Η2〇Η2, CF；〇. (Μ-257, Η, Η, Η, ΗΟΟΟΟΗ2〇Ιΐ2(νΙΐ2〇ϋ2, Hr), (Μ-258, II, II, II, HOOCCII2CII2CH2CH2, CHa), (Μ-2Γ)!), Π, U, II, (Μο)2Να〇ΟΗ2〇Η2〇1ΐ2〇Ιΐ2. Η). ίΜ-260, Η，Η, Η, (Me)2Na)CH2Cll2(〕ll2(:lh，（〕1), (M.2(U, Η, Η, Η· (Μο)2ΝΟΟΟϋ2〇Η2〇Η2〇Η2, l〇, (M-2G2, II, II, II, (MtOaNCOClhCilaClhClh, CF.3), (Μ-263, Η, H, II, (Μο)2ΝΟΟΟΙΐ2〇Ιΐ2(νίΐ2〇Η2, Br), (Μ-264, II, Η, Η, (Me)2NCOCH2CH2CH2CIi2, CU：〇, (M-2G5, II, il, II, (Me)2NCOCH2CH2CiI2CII2CIl2, 11), (Μ·2(Κί, 11，II，11, (Mo)2NCOCH2CIi2CH2CH2Cfl2, Cl), (M-2(57, II, II, II, (Me)2NCOCH2CH2CH2CH2CH2, F), (M.2G8, II, U, II, (Me)2NCOCH2CH2CH2CH2Cri2, ΟΚ*〇, (Μ-^Γίί), II, II, II, (Me)2NCOCH2CH2CIl2CH2CH2, Br), (M-270, Η, Η, Π, (Me)2NCOCH2CIl2CH2CIl2CH2, CIh〇, (M-271, II, II, H, MeOCIh, Μ), (M-272, H. II. H, MeOCH2, Cl), (M-273, Η, Η, II, M0OCH2, F), (M-274, Η, Η, II, MeOCIh, CF3>; (M-275, Η, Η, H, MeOCM2, Hr), (M-27(5, Μ, II, H, MeOCIh, CUs), (M-277. U, II, II, EtOCih, II), (M-278, Π, II, H, Εω(Μΐ2, Cl), (M-279, II, II, II, P'tOCIh. F), (M-280, II, II, II, EtOCIl2, CFm), (M-281, H, H, M, Kt()CH2, Hr). (M-282. H. Η. H, EtOCH2, CH.3), (M-283, H, II, H, lOtOClhClI2, U), (M-284, II, Η, H, EtOCH2CH2, Cl), (M-285, II, H, H, KiOCAhClU^ l·"), (M-286, Η, II, M, EtOCH2CIl2, CF3), (M-287, 11, Η, II, KtOCU^Clh. Hr), (M-288, Η, II, Π, EtOCII2CH2, CU3), (M-289, II, Η, II, MoOCil2CIl2()ClI2CM2, Η), (M-290. II, H. H. MeOCII2CH2〇CH2CH2, Cl), (M-291, II, II, H, Mo()Cil2CIl2〇CIl2CIl2, F), (M-292, Η, Η, H, MeOClhCI^OCiI2OII2, CV：〇, (Μ-2ί)；1, Η, Μ, II, MeOClUClhOClhCAh, Br), (Μ-2ί)^1, II, II, H, MoOCiI2CIl2〇CH2CH2. CAL·). (M-295, II, Η, II, Μο〇αΗ2ΟΗ2, Η), (Μ.25)(ί, Η, Η* H, M0OCH2CII2, Cl), (M-297. H. IL H. MeOCIhCJh, F), (Μ-2ί)8, II, II, M, M0OCH2CII2, CFn), H. H. II. -Hi)- 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公釐） ------------裝---- (請先閱讀背面之注意事項再填寫本頁) 訂· 4 1284^39 A7 ____B7_ 五、發明說明（W )
Mo〇CH2CH2, I3r), (M-300, II, II, II, MoOCIIaCih, (MI；〇, (M-301, Η, II, II, HOCHs, Μ), (M-302, II, II, H, HOCIh, Cl), II, M, H, IIOCH2, (M-304. Η. H, U, UOCII2, CFa), (M-305, II, Η, II, IIOCII2, Hr), (M-306, H, II. H. HOCIIj. CH：〇, (M-307, II, Η, H, HOCIhCHa. II), II, II, II, ΙΙ0(ΊΙ〇(ΊΙ>, (Ί), (M-309, Η, Η, H, IIOCH2CM2, F), (M-JjK), II, II, II, HOCIhCIh, CF：〇, (M-：U 1, II, Η, H, IIOCH2CII2, Br), (M-312, II, Η, II, ΙΙΟ(Ίΐ2〇1ΐ2, Cila), (M-313, Η, Η, H, HOCII2CH2CH2, Η), (M-314, Η, II, II, llOCIhCIhCih, Cl), (M-315, II, II, II, IIOCH2CH2CH2, F), (M-316, Η, II, II, !Ι()ΟΙΐ2〇Η2〇Ιΐ2, CFa), (M-317, II, H, II, HOCU2CH2CH2, Br), (M-318, II, II, II, HOCIiaCIlyCHa, CII：〇, (Μ-；Πί). IL U. II. HOCH2CH2CH2CH2, Η), (M-320, II, II, II, HOCH2CII2CH2CH2, Cl), (M-321. H, II? H, H(jCH2CH2CIl2Cil2, F), (M-；J22, II, Π, II, IIOCII2CH2CH2CII2, CPa), (M-323, Η, Η, Η, ίΙΟΟΙΐ2〇Η2〇Η2(ΊI2, Mr), (M-324, II, H, H, HOCH2CII2CH2CH2, CII：〇, (M-325, II, Η, II, iIOCH2CH2CH2CH2CH2, II), (M-326. II, Η, Η, ΗΟΟΗ2ΟΗ2σΐΐ2〇Π2〇Μ2, Cl), (M-327, II, Η, II, HOCH2CH2CII2CH2CH2, F), (M-32H, II, II, II, HOCU2CH2CH2CH2CH2, CFa), (M-329, Η, Η, II, ΗΟΟΗ2ΟΠ2〇Μ2〇ΙI2CII2, Br), (M-330, U, Η, II, HOCH2CH2CII2CH2CH2, CHn), (Μ.：5；Π, II, II, 1L 11()0112〇112〇0112〇112. H), (M-332, Μ, II, H, HOCAUClhOClhCAht Cl), (M-333, Η, Η, H, HOCH2CH2OCH2CH2, F), (M-3：34, Π, Η, II, IIOCII2CH2OCH2CH2, CFn). (M-335, H. H, H, HOClhClUOClhCAU. Hr), (M.；U3(5, II, U, II, 1100112〇112〇0112〇112, CH：〇, (M-337, Η, Η, Η, (Mo)2N, II), (Μ-ΜΜΗ, II, il, H, (Mo)2N, Cl), (M-339, H. H. II. (Me)2N, F), (M-340, Η, II, II, (Mo)2N, CK：〇, Μ, Η, H, (Me)2N, Br), H，Η, H，（Me)2N, Clh)，（Μ·:Μ3, [I，II，II，脈陡-4-基甲基，11)， (M-344, II，Η,丨I,哌啶-4-基甲碁，（Tl)，丨丨，丨丨，丨1，哌H定-4-基 甲棊.F)，（Μ·ίΜ6, Η, Η, 1丨，哌啶-4-基甲棊，（:1〜)，U，11，11， 峨啶-4-基甲基，Br), (Μ·:ΗΗ, II,丨丨，丨丨.哌啶-4-基甲基，（〕丨丨:〇,（Μ· __!)〇 _ - 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公爱Ί) " 丨丨一丨丨一-----%裝 (請先閱讀背面之注意事項再填寫本頁) 訂---------% 經濟部智慧財產局員工消費合作社印製 1284639 A7 經濟部智慧財產局員工消費合作社印製 _ , B7 _五、發明說明f衫） •349. 1丨，II，H,環己基甲基，Η), (M·:丨5()，H, 1丨，丨丨，環己基甲基，⑶， (M-3/31，Η, Η, H,環己基甲基，l·’)，（M-:川2,丨1，丨1· II·環己基甲基， CFs). (Μ-3Γ)3, ίΐ，H，H，環己基甲基，Br)，（Μ·354, H，H, 11， 環己基甲基，〇η·3)，（Μ·3Γ)5, Η, Η，Η, Π)，（Μ-3Γ)(3, Η, H, F，H, Cl). (Μ-357, II. II. F, Η, F), (Μ-358, II, II, F, It, ΟΙΛμ), (Μ-；5Γ)ί), II, II, II, Hr), (M-；U；(), 11, 11, F. H, CII3), (M-361, Η, H, F, F, H), (M-362, II, II, F, F, Cl), (M-363, II, H. F, F, F). (M-3G4, Η, H, F, F, CF.i), (Μ.：](}Γ), II, II, F, F, Hr), (M-366, Η, II, F, F, ClI：〇. (M-367f Η, ΪΙ, F, Cl, II), (M-3G8, II, II, F, Cl, Cl), (M.；K59, II, H. F, Cl, F). (M-370, H. H, F, C), CF3), (M-371, II, II, K, 01, Hr), (Μ-：Π2, ll, 11, K. Cl, CI1；0. (M-373, II, H, F, CHs, II), (M-374, II, II, F, Oil,*3, Cl), (M-375, Η, H, F, CHa, F). (M-376, Η, H, F, CII3, CF3), (M-377, Η, H, F, Clht Hr), (M-378, II, II, F. CAL·, CH.〇, (M-379, Η, H, F, Et, H), (Μ-ίίΗΟ, II, II, K, KU Cl), (M-381, II, II, F, Kt, F), (M-382, H, II, F, Et, CF3), (M-383, Η, II, K, lit, Br), (M-384, II, II, F, Et, CII：〇. (M-385, II, H, F, n-Pr, II), (M-386, Η, II, P, n-Pr, Cl), (M-387, II, II, F, n-Pr, F), (M-388, II, H, F, n-Pr, CFa), (M-389, II, Π, F, n-Pr, Br), (M-390, II, II, F. n-Pr. CH3), (M-391, Η, II, F, c-Pr, II), (M.JJ92, H, II, F, c-Pr, Cl), (M-393, II, H, F, c-Pr, F). (M-394, II, II, F, c-Pr, CF；〇, (Μ.：Η)Γ), Π, il, b\ oPr, Br), (Μ-3ί)ΰ. II, 11. F, c-Pr, CII3), (M-397, Η, H, F, i-Pr, H), (Μ.；1ί)Η, It, II, F, i-Pr, Cl), (M-399, II, H. F. i-Pr. F), (M-400, II, H, F, i-Pr, Cl^〇, (M./101, Η, II, F, i-Pr, Br), (M-402, Η, H, F, i-Pr? CH3), (M-403, Η, H, F, η-Ηυ, II), (M-404, II, II, K, n-Bu, Cl), (M-405. II, Π, F. n-Bu, F), (M-406, H, II, F, n-Hu, CPn), (M-407, Π, II, F, n-Bu, Br), (M-408, Π, H, F. n-I3u. CII3), (M-409, II, Η, K, i-Hu, II), (M-dlO, II, H, F, ί-Bu, Cl), (M-411, Η. H, F, i-Bu, F), (M-412, Η, II, K, i-Hu, CKn), (M-41；5, H, H, F, i-Bu, Br), (M-414. II, II, F, i-Βυ, CH〇, (M-415, II, H, K, «ec-Bu, II), (M-416, II, II, F, sec-Bu. Cl). (M-417, Μ, H, F, roc-Bu, P), II, II, K, soc-Hu, CK：〇, (M-119. II. H. F, sec-Bu. Br), (M-420, II, II, F, soc-Hu, CH；〇, (M-421, H, II, K, η-Γοη, Η). (M-122. i)l 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） (請先閱讀背面之注意事項再填寫本頁)
.''V 裝----- ϋ i_i i_i 1 、 I I am aas 訂 1284639 A7 _B7_ 五、發明說明（％ ) Η, II. F, n-Pen, Cl), (M-423, Μ, Η, K, n-Pon, F), (M-424, II, II, F, n-Pon. CF；0, (M-425, Η, II, F, n-Pen, Br), (M^2(!t II, Η, K, CH：〇, (M-427, II, II, F. c-Pen. H), (M-428, II, H, F, c-Pon, Cl), (M-^125), II, II, ΙΛ c-Pon, F), II. II. (請先閱讀背面之注意事項再填寫本頁) F. c-Pon, CF：〇, (M-431, Η, H, F, c-Pon, Hr), (M-432, Π, II, F, c-Pon. ClI：〇. (M-4:3:3. H, H, F, η-ΙΙβχ, II), li, li, l\ n-llox, Cl), H, 11, K, n-llox, K). (M-436, Η, H, F, n-Hex, CF3), (M^H7, H, II, F, n-Hox, Br), (M-438, Η. H, F, n-IIex. CMr〇. (M-439, Η, II, K, c-IIox, II), (M-^14(), 11,11, F, ollox, Cl), (M-441. H, H. F? c-ilox, F), (M-442, H, U, F, c-liox, CKm), Η, II, K, c-IIox, Hr). (M-44i, II, H, F, c-ίΐοχ, CII3), (Μ-Ί45, II, II, F, OH, Η), (Μ-4ΊΓ>, II, II, F, OH, Cl). (M-447, II, H, F, OH, F), (M-448, 11, II, F, OH, GF3), (M-449, H, II, F, OH, Br). (M-450, II, II, F, OH, CHa), (M-451, ΙΪ, Π, F, EtO, II), (M-452, II, II, F, EtO. Cl). (M-453, Η, H, F, EtO, F), (M-454, H, II, F, EtO, CFn), (M-455, Η, II, F, EtO, Br), (M-45G, II, H, F, EtO, CHs), (M-457, II, II, F, n-PrO, II), (M-458, Η, H, F, n-PrO, 經濟部智慧財產局員工消費合作社印製
Cl). (M-459, Η, H, F, η-PrO, F), (Μ-4(50, il, II, F, n-PrO, CF3), (M-461, II, H, F, n-PrO, Br), (M-462, Η, II, F, n-Pr(), CH；〇, (M-4G3, Μ, II, F, PhO, H). (M-4G4, H. H. F? PhO, Cl), (M-465, II, II, F, PhO, F), (M-4GG, II, II, F, PhO, CFa), (M-4G7, H, H, F, PhO, Br), (M-468, Η, H, F, IMiO, CIIm), (M-4G9, II, H, F, BnO, Η), (M-470. Η. Π, F, BnO, Cl), (M-471, II, II, ΙΛ BnO, F), (M-472, Μ, II, F, RnO, CF：〇. (M-473. Η, H, F, BnO, Br), (M-474, II, U, K, BnO, CH：〇, (M-475, Η, II, F, PhCH2CIl2〇, Η), (M-476, Η, II, F, IMiCIhCIPiO, Cl), (M-477, II, II, F, PhCH2CH2〇, F), (M-478, II, II, F, 1^101120112(), CFn), (M-479, II, H, F. PhCH2CIl2〇, Br), (M-480, II, II, b\ tMiCIlaCIIaO, CU：〇, (M-481, II, II, F, CFaO, Η). (M.482, Η, H, F, CFaO, Cl), II, II, CI^O, l〇, (M-484. II, H, F, CF3O, CFa), (M-485, Η, H, F, CPmO, Hr), (M-d8(；, Η, II, F, CPaO, CH；0. (M-187. II. II. F, Ph, H), (M-488, II, II, F, IMi, Cl), (Μ.48ί), H, II, F, Ph, F), (M-190, Η, ll. F. Ph, CF：〇, (M-491, Η, II, F, Ph, Hr), (Μ·4ί)2, II, 11, ΙΛ Ph, CUn), (M-493. H. II. !)2 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 __B7___ 五、發明說明（9() F. 4-F-Ph, II), (M-494, II, II, F, A-l^V\h ΟΙ), (Μ-Ί95, II, II, F, l-F-Ph. F). (M-190. Η. II. F, 4-F.Ph, CFa), (M-497, II, II, K, Hr), (M-498, Η, II, F, 4-F.Ph, CH3), (M-499, Η, H, F, 4-CF3-Ph, Μ), (Μ-βΟΟ, II, II, F, d-CFa-Ph, Cl), (Μ-5()1, H. H. F. 4-CF3.Ph, F), (M-502, Η, H, F, ^CFn-Ph, CFr〇, (M-503, Η, II, F. 4-CFa-Ph. Br). (M-504, II, U, F, 4-CFa-Ph, CU：〇, (Μ-Γ,ΟΓ), II, II, l\ 4·(Μο)2Ν-ΙΊι, II), (M-5()(；, Η. H，F，4-(Me)2N-Ph，Cl), (Μ·Γ)07, 11，Π, F, 4-(Me)2N'Ph, F), (M-508, H，H, F. 4.(Mo)2N-Fh, CFa), (M-50i), Η, II, ΙΛ 4.(Μ(〇2Ν-ΙΜι, Hr), (M-BIO, II. II, F, 4-(Me)2N-Ph, CII3), (M-511, 11, II, F, II), (M-512, Η, II, F, ^l-OII-Ph, Cl). (M-513, Π, H, F, 4-OII-Ph, F), (Μ-Γ)Η, II, II, F, 4-OH-IMi, CF：〇, (Μ-51Γ>, 11. 11. K, 4-OH.Ph, Br), (M-516, H, H, F, 4.〇l|.Ph, Clin), (M-517, Η, II, F, 3,4-di-F.Ph, 11). (M-518, II, H, F, 3,4-di-F.Ph, Cl), (Μ-β19, H, II, F, 3,4.di.F-Ph, F), (M-520, Η, H, F. 3.4-di-F.Ph, CF3), (M-521, II, !1, l·1, Br), (M-522, H, II, F, 3,4- di-f^Fh, Clh), (M-523, Η, II, P, 4-00()11.1^1, II), (M-524, U, H, F. 4-C(H)H-Ph. Cl). (M-525, II, H, F, 4.C001I-Ph, K), (M-52G, Μ, Η, P, 4-COOIl.Ph, CF：〇, (M-527. II, II, F, 4-COOII-Ph, Hr), (M-528, II, II, F, 4-C0()ll.Ph, CH：〇. (M-529, H. H, F, Bn, Η), (M-530, II, II, F, Bn, C!), (M-RSl, Η, Η, K, Bn, F), (Μ-Γ332, Η, II, F, Bn. CF3), (M-533, H, H, F, Bn, Br), (Μ-5；Μ, II, H, F, Bn, CM；〇, (Μ-53Γ), Η. H. F, 4-F-Bn, II), (M-536, H, U, F, 4-F-Hn, Cl), (Μ.Γ)；Π, II, II, K, 4-F.Bn, F). (M-538. Η. H, F, 4-F-Bn, CF3), (M-539, II, II, P, 4-K.Hn, Br), (M-540, II, II, F, 4-F-Hn. CH：〇, (M-541, Η, II, F, 2-Py, Π), (Μ-Γ,/|2, II, II, F, 2-Py, Cl), (M-543, II. II, F. 2-Fy, F), (M-544, II, H, F, 2-Py, CKm), (Μ-Γ)4Γ>, II, II, F, 2-Py, Br), (M-54G, II. H, F. 2-Py, CII3), (M-547, II, ll F, 3-Py, II), (M-548, Π, II, F, 3-Py, Cl), (M-549, II, H. F. 3-Py, F), (Μ-5Γ3〇, H, H, F, ：hVyt OK；〇, (M-551, Η, Η, ΙΛ 3-Py, Br), (M-552, Η. H, F, ：3-Py, CAh)f (M-553, II, II, l·1, 4-Py. H)» (Μ-Γ)Γ)4, II, M, F, 4-Py, Cl), ίΜ-555, ll U, F, 4-Py, F), (Μ-Γ)Γ,0, II, II, P, /l-Py, CFn), (Μ-Γ)57, II, II. F. 4-Py. Br). (M-558, Η, II, F, 4-Py, Clin), (Μ-Γ)Γ)ί), II, II, F, 2-Th, H), (Μ-Γ)(Η). Η. H. F. 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) ，裝 . 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（P ) 2-Th. CI), (Μ-561, Η, Η, F, 2-Th, F), (Μ-Γ)(52, II, 11, 2-Th, CF；〇, (M-5Ga. Π, Η. F. 2-Th. Hr), (M-5G4, Μ, II, F, 2-Th, Clin), (Μ-Γ)(5Γ), II, II, F, ；?-Th, H), (Μ-Γ)(；(5, 11, H. F. ：3-Th, Cl), (M-0G7, II, II, P, ：M1h, !〇, (Μ.Γ,(ί8, II, II, K, ；i-Th, CK〇. (Μ-Π(；5). Η, H, F，.Vrh，Br)，（Μ·Γ)70, Η, Η, P, 3·ΊΊι, Clh)，（Μ·67】，Π，H，F，吡唑-2-碁, liMM-572, Π，H，F，吡唑-2-基，（」)，（M-G7M，II，II，l·1,吡唑-2_基，卜、)，01-574. H，H，F，吡唑-2-基，CF3), (Μ·Γ>7ΜΙ,11，F,吡唑-2-基，Br)，（M-576, Η， H. F，吡唑-2-基，CH:;), (Μ-Γ)77,丨I, II，l·1，吡唑-3-碁，1 丨)，（M478, Π, 1丨，l·’, 壯 0¾ ·3-基，(〕1)，（Μ-Γ)7ί)，II, I I, ΙΛ 吡唑-3-基，1〇, (Μ·Γ)80· Η，Π, l·' 吡唑-3-基，CF3), (Μ-Γ)81, 1 丨，11, Κ，吡唑-3-基，Br〇, (Μ·Γ>82,丨丨，11，F， 吡唑-3-基，OHO，（M-583, II，丨丨，K,嘧啶-2-基，⑴，（Μ-584, Η, II，l·' 嘧啶-2-基，Cl)，（M-585, H，H, l·1,嘧啶-2-基丨，F), (Μ·Γ)86, II, II，F， 喃陡-2-基，CF.3), (Μ··587,丨丨，丨丨，K,嘧啶-2-基，Β〇,（Μ-Γ)88. H. II，ΙΛ 喃陡-2-基，C[l3), (Μ·Γ)89, Π，fl，ΙΛ 嘧啶-4-基，II), (Μ·Γ)90, [[, II, F， 嘧啶-4-基，Cl), (Μ·591, II，I丨，Κ，嘧啶-4-基，F)，（Μ·592, II，H, F, 嘧啶-4-基，CFV), (Μ-5ί)3, Η，Η,Κ 嘧啶-4-基，Br), (Μ-594, Π, Η· F. 嘧啶-4-基丨，(Μ·δί)(3,丨丨，丨丨，F，嘧啶-5-基μ Η), (Μ-Γ)ί)(ί，丨丨，丨丨，F， 嘧啶-5-基，Cl)，（M-597, LI, H，K,嘧啶-5-基，F)，（Μ·Γ)ί)8, II，II，F· 嘧啶-5-基，d〇,（Μ·59ί)，II，1丨，l·' 丨嘧啶-5-基，lir)，（M-GOO,丨丨· Π, F, 嘧啶-5-塞，〇出)，（M-GOl, 11，II，K，ll()()C(:lhCll2(m2, U)，（M-(;02, U，II，h HOOCCH2CII2CU2, Cl), (M-G03, II, U, ΙΛ II()()C(：ll2CI[2CIl2, F), (M-GOl, II. H. F, H(XJCCH2CH2CH2, CF.〇, (Μ.(；ΟΓ), II, II, F, Il()OCCH2CH2CM2, Hr), (M.GOG. Η. II, F, HOOCCH2CII2CH2, CH：〇, (M.f；07, II, II, ΙΛ HOOCCH2CII2CII2CH2, H). (M-G08, Η, H, F, IIOOCCII2CII2C1IUCII2, (Ί), (M-(5()i), Μ, II, ΙΛ HOOCCII2CH2CII2CII2, F), (M-(5I(), II, Π, l·1, ΙΙ〇()(：ΟΙΙ2(ΜΙ2(：Η2(：1Ι2, CF：0. (M-β11. Η. II, V, HOOCCH2CIl2CIl2(vlh, Rr), (M-(；12, II, 11, F, IIOOCCII2CH2CH2CH2, CH：〇, (M-(51：{, II, II, V\ (Mo)2NCOCII2Cll2CH2Cll2. H). 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ! u ——.-----·裝------ (請先閱讀背面之注意事項再填寫本頁) 訂i 經濟部智慧財產局員工消費合作社印製 1284639 A7 ___B7_ 五、發明說明（^ ) (Μ-βΗ, II, II, F, (Me)2NCOCIl2Cil2CH2CU2< Cl), (Μ-(Η5, II, H. F, (Mo)2NCOCIl2Cil2CIl2CIl2, F), (Μ-ΠΗί, Η, II, K, (MoiaNCOClIsCIhCIhCHo, CFri), (M-617, Η, II, F, (Μο)2ΝΟΟΟΙΐ2〇Η2ΟΙ!2〇Ιΐ2, Br), (M-G18, II, II, F. (Me)2NCOCH2CH2CH2CH2, CHa), (M-Gli), II, II, F, (Me)2NCOCll2CIl2Cll2Cll2Cll2, II), (M-(52(), II, II, K, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-621, Η, H, F, (Μο)2ΝΟΟΟ!ΐ2〇Ιΐ2〇Γΐ2〇ΙΙ2〇ίΐ2, I〇, (M-022, II, II, F, (Me)2NCOCH2CH2CH2CIi2CH2, CFn), (M-G23, II, Η, ΙΛ (Me)2NCOCH2CH2CH2CIl2CIl2, Hr), (M-G24, II, M, F, (Me)2NCOCH2CH2Cll2CH2CH2, CII：〇, (M-G25, II, Μ, ΙΛ MeOClh, 11), (M-G2G, H, H, F, MeOCIh, Cl), (M-627, Η, H, F, M0OCH2, I〇, (M-628, Η, H, F, MeOCH2, CF3). (M-629, II, II, F, MeOCII2, Hr), (M.(5；]〇, 11, II, F, M0OCII2, CHa), (M-631, II, H, F, E1OCII2, Η), (M-G32, II, U, l·1, Ι^Ο(：Ι[2, Cl), (M-6H3, II, II. F, KtOCIl2. F). (M-634, Η, H, F, EtXJCIh, CFn), (Μ-03Γ), II, II, F, KtOGIh, Br), (M-63G. Η, H, F. EtOCH2, CH3), (M-637, Η, Η, K, KtOGIhCIh, Η), (M-638, Η, II, F, EtOCII2CH2, Cl), (M-639, H, II, F, KtOCM2CH2, F), (M-640, Η, H, F, f]tOCH2CH2, CF3), (M-641, II, II, F, KtOCH2CH2, Hr), (M-642, Η. H, F, EtOClhClh, CHn), (M-643, II, II, K, Mo()CH2CIi2〇CH2Cll2, II). (M-G44. Η. Π. F. MCOCH2CII2OCH2CH2, Cl), il, II, ΙΛ Μο〇〇Ιΐ2〇1ΐ2〇01ΐ2〇Η2, F), (M-646, H, H, F, MeOCH2CH2〇CIl2Cn2, CFn), (M-G47, H, II, F, MeOCH2CH2〇CH2CH2, Br), (M-fMH, II, II, F, MoOCIl2CH2〇CH2CH2, CHa). (M-649, il, H, F, MeOClhClh, II), (M-GCO, II, II, ΙΛ MeOClhClh, Cl), (M-651. IL II, F, MeOCIl2CH2, F), (M.()52, II, II, K, M0OCH2CH2, CFa), (M-653, H, H, F. MeOCH2CIl2, Br), (M-654, Π, II, K, MoOCIhiMh. (Min). (M-G55, II, H, F, HOCH2, Η), (M-656, H, If, F, IIOCII2, Cl), (M-(557, II, II, ΙΛ IIOCH2, F). (Μ-(>Γ)8. H. H. F? HOCH2, CFa), (M.659, II, II, F, [IOCH2, Br), (M-660, Π, Π, F. IIOCH2, i)5 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注音？事項再填寫本頁) 丨^^裝--------訂--------- I2M639 A7 __B7_—_ 五、發明說明（Μ )
Clh). (M-G61, Π, II, F, ΙΙΟΟΠ2(>ΙΙ2) II), (Μ-ββ2, II. II. F, HOCHsCIl·^ Cl), (Μ-f3G3, Η, U, F, HOCH2CH2, F), (Μ-(](54, H, II, F, HOCH2CH2, CFa), (M-GG5. Η, II. F. HOCH2CH2, Br), (M-666, Η, II, K, IlOCIIaCl^, Clin), (M-G67, II. Π, F, HOCII2CH2CH2, II), (M-668, If, II, ΙΛ MOCIIsCII2CII2, Cl), (M-GGi). Π. II. F. HOCH2CII2CH2, F), (M-670, 11,H, M〇Cil2Cll2Cll2, CF：〇, (M-(；71, II, II, F, HOCH2CII2CH2, Br), (M-672, Η, Μ, P, IίΟΟΙΐ2〇Ι1201ΐ2, CBa), (M-673, II, H, F. HOCH2CH2CH2CH2, Ii), (M-674, JI, II, ΙΛ !I()Cil2Cll2CIl2Cll2, Cl), (M-G75, II, H, F, HOCU2CH2GII2CII2, F), (Μ-(57β, II, II, F, IIOCII2CII2CII2CH2. CK：〇. (M-677. II, II, F, HOCII2CH2CII2CM2, Hr), (M-078, II, II, K, IIOCII2CII2CH2CU2. CHa), (M-679, Η, H, F, HOCH2CH2CM2CH2CII2, Η), (M-680, Η, H, F, HOCII2CH2CH2CH2CH2, Cl), (M-(581, li, 11, l·1, 1ΙΟΟΙΐ2〇1ΐ2〇Ιΐ2〇Ιΐ2〇Π2, F). (M-682, II, H, F, ΗΟΟΗ2ΟΜ2〇Ιΐ2〇Π2〇Ιΐ2, CK：〇, (M-G83, II, M, F, HOCH2CII2CII2CII2CH2, Br), II, II, F, HOCII2CM2CH2CH2CH2, ClI；〇, (M-685, Η, H, F, HOCH2CH2OCU2CU2, 11), (M-686, H, II, F, HOCH2CH2OCH2CH2, Cl), (M-687, Η, II, F, HOCH2CII2OCH2CH2, F), (M-688. Η, H, F, HOCH2CH2OCH2CII2, CFr〇, (M-(589, II, II, F, HOCII2CH2OCM2CH2. Br). (M-G90, Η, II, F, MOCH2CH2OCII2C!I2, CUn), (Μ.(5ί)1, II, M, F, (Mo)2N. H), (M-692, H, II, F, (Me)2N, Cl), (M-OU；}, II, II, (Mo)2N> F), (M-G94, II, II. F, (Me)2N, CF3), (M-695, II, II, F, (Mo)2N, Br), (M-GiK；, H, H, F, (Mo)2N, CII3), (Μ·6ί)7, Η, H, F,哌啶-4-棊甲棊> 1丨)，（M-G98, Π, 11，P,哌 Π定-4-基 甲基，C1)，（Μ·699, II，11，F，哌啶-4-基甲基，F), (M-700, Η, H，F， 哌啶-4_基甲基，CF3), (Μ·7()1, 1丨，If, F，哌啶-4-基甲基，Br)，（Μ· 702,丨丨，1丨，F，哌啶·4-基甲基，（HIm), (Μ·70;丨，丨丨· Η, Κ·環己棊甲棊， Η), (Μ-7(Μ,丨丨，丨丨，F,環己基甲基，（:丨)·（Μ·70Γ), II,丨丨· l·’.環己基甲棊， F). (M-70G,丨丨，11, IV環己基甲基3 (:丨〜)，（Μ·7〇7,丨丨，1丨，K環己基甲碁， L⑺·（Μ·708, Η, II, 環己基甲基〆〕丨〖:0,（Μ·7(Μ)，11，丨1，（〕丨，11，1 丨)，（Μ·71()· _ίΚ5_ 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公髮) (請先閱讀背面之注意事項再填寫本頁) 丨^^ 裝--------訂--------- 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、發明說明（八） Η. II, Cl, II, Cl), (M-71 1, H, II, Cl, II, P), (M-712, II, II, Cl, II, CF；〇, (Μ-7Ι；5, Η. H. CL II, Br), (M-714, Η, H, Cl, II, 01I:〇, (Μ-71Γ3, H, 11, Cl, F, II), (M-71G, Η, H,
Cl. F. Cl), (M-717, Η, H, Cl, F, F), (M-718, Μ, II, Cl, F, CFa), (M-719, II, Π, CL F. Br), (M-720, Η, H, Cl, F, CHn), (M-721, H, II, Cl, Cl, Η), (M-722, Π. H. Cl. Cl. Cl), (M-723, H, H, Cl, Cl, F), (M-724, II, II, Cl, Ci, CKa), (M-725, II, 11, Cl, Cl, Br), (M-72G, Η, H, Cl, Cl, CH：〇, (M-727, II, II, Cl, Clin, II), (M-728, II, II. Cl. CII3, Cl), (M-729, Η, II, Cl, CIIm, F), (M-7；K), H, II, Cl, Oils, CFn), (Μ-7：Μ, H. H. Cl. Cl!.% Br), (M-732, II, H, Cl, Cll；», Cll；〇, U, II, C\t Et, II), H, H, Cl, Et, Cl), (M-735, Μ, H, Cl, K), (Μ-7：Η5, II, II, (^1, lit, CF；〇. (M-7：?7. II. H.
Cl. Et, Br), (M-738, Η, H, Cl, Et, CHa), (M-739, Η, H, Cl, n-Pr, Η). (M-740, Η. H,
Cl? n-Pr, Cl), (M-741, II, H, Cl, n-Pr, F), (M-742, II, II, Cl, n-Pr, CFa), CM-743. II. H. Cl, n-Pr, Br), (M-744, H, H, Cl, n-Pr, CII：〇, (M-745, II, H, Cl, c-Pr, Π), (M-746, H, II, Cl, c-Pr, Cl), (M-747, H, It, Cl, c-Pr, P), (M-748, 11, II, Cl, o-Pr, CFa), (M-749, II, II, Cl, c-Pr, Br), (Μ-7Γ)0, Η, II, Cl, c-Pr, Clla), (M-751, II, 11, Cl, i-Pr, II), (M-752, Η, H, Cl, i-Pr, Cl), (M-75i}, H, II, Cl, i-Pr, F), (M-754. H, II, Cl. i-Pr, CF.3), (M-755, Η, H, Cl, i-Pr, Br), (Μ-7Γ>0, II, II, Cl, i-Pr, CH；〇, (M-757. H. H. Cl, n-Ru, II), (M-758, H, If, Cl, n-Hu, Cl), (Μ-7Γ){), II, H, Cl, n-Bu, F), (M-7G0. H, H, Cl, n-Hu, CF〇, (M-7G1, II, II, Cl, n-Mu, Hr), (Μ-7(ί2, II, II, Cl, n-Bu. CH；0. (M-7G3, II, H, Cl, i-Βυ, Η), (M.7(M, II, M, Ci, i-Bu, Cl), (M-765, Η, II, Cl, i-Bu. F). (M-766, II, II, Cl, i-Bu, CFh), (M-7(i7, II, fl, Ci, i-Bu, Br), (M-768, II, II, Cl. i-Bu, Clh), (M-769, Η, H, Cl, boc-Bu, Μ), (M-770, H, II, Cl, soc-Bu, Cl), (M-771, Η, H. Cl, sec-Bu, F), (M-772, H, ii, Cl, soc-Hu, CFa), (M-773, Η, II, Cl, soc-Bu. Hr). (M-774, Η, II, Cl, boc-Mu, CHm), (Μ-77Γ), II, II, Cl, n-Pon, II), (M-77G, Η, H, Cl. n-Pon, Cl), (M-777, II, II, Cl, n-IVn, P), (M-778, II, li, Cl, n-IVn. CF；〇. (M-779. II. II. Cl, n-Pen, Br), (M-780, II, II, CL n-Pon, Clin), (M-781, II, II, Cl. c-Pen, Η), (M-782, Η, H, Cl, c-Pon, Cl), (M-783, II, Π, Cl, c-Pon, F), (M-78 t, II. 11. !)7 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) 裝--------訂--------- 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 ____B7__ 五、發明說明（# )
Cl, oPon, CF：〇, (M-785, Μ, II, Cl, ol^n, Hr), (Μ-78(5, II, II, Cl. c-Pimu (ΊΙ；0. (M-787. II, II, Cl, n-Hex, II), (M-788, II, II, Cl, n-iiox, Cl), (M-789, II, H, Cl, n-Hex, F), (M-790, Η, II, Cl, n-IIox, CK;〇, (M-75)l, II, II, Cl, n-llox, Hr), (M-792, H. II. Clf n-Hex, CHa), (M-793, II, II, Cl, c-IIox, II), (M-794, II, II, Cl, c-Hex, Cl). (M-795, H, II, Cl, c-Hox, L〇, (Μ-7!)(ί, il, II, Cl, c-ilox, (JK；〇, (Μ·7ί)7, li, U, Cl, c-IIex, Br), (M-798, Η, H, Cl, c-IIox, CH：〇, (M-799. Η, H, Cl, OH, Η), (M-800, H. H, Cl, Oil, Cl), (M-801, II, H, Ci, OH, K), (M-H02, H, II, Cl, OH, CKn), (M-803. II. II. Cl, OH, Hr), (M-8(H, Η, II, Cl, Oil, Clla), (M-805, IL 11, Cl, litO, II). (M-80G. H. H, Cl, EtO, Cl), (M-807, II, II, Cl, Kt(), P), (M-HOH, H, II, Cl, IitO, CF：0. (M-809, II, H, Cl, EtO, Br), (M-810, Η, H, Cl, EtO, CH3), (M-811, H, II, CL n-PrO, Η), (M-812, II, H, Cl, n-PrO, Cl), (M-813, II, II, Cl, n-PrO, F), (M-814, II. II. Cl, n-PrO, CF3), (M-815, II, II, Cl, n-PrO, Hr), (M-816, Η, II, Ci, n-PrO, CAL·), (M-817, II, II, Cl, PhO, II), (M-818, II, Π, Cl, PhO, Cl), (M-Hli), 11, II, Cl, PhO, F). (M-820, II, H, Cl, PhO, CF3), (M-821, II, II, Cl, PhO, Hr), (M-822, Η, II, Cl, PhO. Clh), (M-823, H, II, Cl, BnO, Η), (M-824, II, H, Cl, BnO, Cl), (M-825, Η, II, Cl, I3nO, F), (M-826, II, H, Cl, BnO, CFr〇, (M-827, Η, H, Cl, BnO, Hr), (M-828, II. H, Cl, BnO, CH3), (M-829, Η, II, C), PhCll2CII20, Η), (M-830, H, II. Cl, PhCH2CU2〇, Cl), (M-831, II, Π, Cl, PhCIi2Clf2〇, F), (M-832, II, II, Cl, PhCIl2CH2〇, CF3), (M-833, li II, (M, 1^101120112(), Br), (M-834, II, II, Cl, PhCH2CIl2〇, CII3), (M-835, Π, II, Cl, CF.mO, Η), (M-836, H, II, Cl, CF..O, Cl). (M-837, H, II, Cl, CF3O, F), (M-838, II, H, Cl, CFmO, CFa), (M-839, Η, II, Cl, CF.3O, Br)t (M-840, Η, II, Cl, CP3O, CIl：〇, (M-841, H, II, Cl, Ph, II), (M-842, II, H, Cl, Ph, Cl), (M-843, H, H, Cl, IMi, (M-8^1^1, Μ, II, Cl, Ph, CF,〇, (M-845, II. IL Cl. Ph, Br), (M-846, Μ, II, Cl, IMi, Cli：〇, (M-8d7, II, II, Ci, II). (M-818. II, II. Cl, 4-F-Ph, Cl), (M.845), II, II, 01, K), (M-850, II, II, CL 4-P-Ph. CFs), (M-851, Η, II, Cl, 4-F-Ph, Hr), (M-852, II, II, Cl, 4-F.Ph, CII3), (Μ-8Γ33, H. »8 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) 0 · ϋ am— ·ϋ n I 一 口 γ I i-i ϋ ϋ «ϋ ϋ ϋ ·ϋ I _ 1284639 A7 B7 五、發明說明（π ) U. CA, ^-CF.vPh, II), (M-854, II, II, Cl, Cl), (Μ-85Γ), II. II, Cl,
Ph. F). (M-856, Η, II, Cl, 4-CF.vPh, CF：〇, (M-857, H, II, Cl, 4.CF^Fh, Br), (M-858, U, H, Cl, 4-CF,3-Ph, CII；〇, (M-859, li, 11, Cl, 4-(Me)2N-Ph, II), (M-8G0. II, H. Cl. 4.(Me)2N-Ph, Cl), (M-861, Η, II, Cl, ^-(Mo)2N-Ph, F), (M-862, Η, II. Cl. 4-(Μο)2Ν.Ρ1ι, CFa), (M-8G：], il, II, Cl, 4-(Μ(〇2Ν-ΙΜι, Hr), 11, II, (Π, 1- (Me)2N-Ph, CII3), (M-865, II, II, Cl, /l-OIl-Ph, Μ), (M-866, Η, H, Cl. 4-OH-Ph. Cl). (M-8G7, Η, H, Cl, 4-OH.Ph, F), (M-808, II, II, Cl, /l-OII-Ph, CF：0, (M-8G9. H. H. Cl, 4.〇H.Ph, Br), (M-870, II, H, C!, d-OIi-Ph, ClIi〇, (M-871, Π, II, Cl, 3,4-cli-F-Ph, H), (M-872, Η, H, Cl, ：],4.(Ιί.Ι<1.ΙΜι, Cl), (M-873, Μ, II, Cl, ；?,4-di-F-Ph, F), (M-874, II, H, Cl, 3,4-di.F.Ph, CKO, (M-875, Η, II, Cl, 3,4.(li-F-Ph, Br). (M-87G, Η, H, Cl, 3,4-di.F-Ph, Clla), (M-877, II, II, Cl, d-COOH-Ph, 11), (M-878, Η. H, Cl, 4.COOH-Ph, Cl), (Μ-87ί), II, II, Cl, 4.〇()()1Ι.ΙΊι, F), (M-880, II. H, Cl. 4.COOII-Ph, CFa), (M-881, II, II, Cl, /l-COOH-Ph, Br), (M-882, II, H, Cl, 4-COOH-Fh, CII3), (M-883, II, II, Ci, Μη, Η), (M-884, II, H, Cl, Bn, Cl), (M-885, II, H. Cl. Bn, F), (M-886, Η, II, Cl, Bn, CP：〇, (M-887, II, 11, Ci, Bn, Hr), (M-888. II. H. Cl, Bn, CII3), (M-889, H, H, Cl, /l-K-Bn, Η), (M-8i)(), II, M, Cl, 4-F-Hn, Cl). (M-89】，II，H, Cl, 4-F'Bn, la II，11, (〕l,心Ρ'Βη，Cl、），（Μ·8ί)3, Π,丨 1, Cl, 經濟部智慧財產局員工消費合作社印製 I裝----- (請先閱讀背面之注意事項再填寫本頁) 4-F-Bn, Br), (M-894, II, II, Cl, 4-F-Hn, CHm), (Μ.8ί)Γ), II, II, Cl, 2-Py, II), (M-89G, Η, H, Cl, 24)y，Cl), (M-8!)7, U, II，2-Py, l·》，（Μ·Η!)8, 11, H, Cl，2-Py, Gh), (M-899, Η, II, Cl, 2-Py, Br), (Μ-ί)()(), II, H, Cl, 2-Py, CiI；〇, (M-901, II, H, Cl 3-Py, Η). (M-902, Η, ΓΙ, Cl, 3-Py, Cl), (M-903, II, H, Cl, il-Py, F), (M-904, II. II, Cl. 3-Py, CF；3), (M-905, II, II, Cl, 3-Py, Hr), (M-iJOG, II, II, Ci, 3-Py, CH：〇, (M-l)07, H. II. Cl, 4-Py, II), (M-908, Η, II, Cl, 4-Py, Cl), (Μ-ί)Οί), II, II, Cl. 4-Py, F). (Μ-ί)10. H. II. Cl, 4-Fy, CF3), (M-911, II, II, Cl, Hr), (M-!)12, II, H. Cl. 4-Py, CH：0. (M-913. H. H, Cl, 2-Th, II), (M-l)H, II, II, Cl, 2-Th, Cl), (Μ-ί)15, II, II. Cl, 2-Th, F). (M-916, Η, H, Cl, 2-Th, CF3), (M-917, II, II, Cl, 2-Th, Br), (M-918, Η. H. Cl. {)!) 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 1284639 經濟部智慧財產局員工消費合作社印製 A7 ___B7 ___ 五、發明說明（W ) 2-Th; (；1Ι：〇, (M-919, Η, II, Cl, H-Th, Η), (M.920, Η, II, Cl, 3-Th. Cl). (Μ-ί)21. II, II. Cl. 3-Th, F), (M-922, II, H, Cl, ；]-Th, ΟΙΛ·〇, (M.；)2：l Π, II, Cl 3-Th, Hr), (M-924. H· 11, Cl，3-Th, CH.3), (Μ·92Γ)，1U1，（n,吡唑-2-碁，II), (M-92G, !1，U, Cl^ 吡唑-2·基，Cl)，（Μ·927, II，丨丨，（:丨，吡唑-2-棊，K), (Μ·ί)28·丨丨，H, Cl, 吡唑-2-基，(Μ-ί)2ί), II，II，（:1，吡唑-2-基，Br)，II，II，（，1， 吡唑-2-基，CHs)，（Μ-ί)31, Η,丨丨，Cl,吡唑-3·基，Η)，（Μ-932, Η, II, GL 吡唑-3-基，C1)，（Μ·933, Η, 1 丨，（〕1,吡唑 _3-基，F), (Μ-934, Π, Π, Cl. 吡唑-3-基，CF3), (Μ·93Γ),丨丨，Π,(〕丨，吡唑-3-棊，Br), (M-93G, Ιί，ΙΊ, Cl· 吡唑-3-基，cii3)，（μ·937,丨丨，丨丨，（〕Ι,嘧啶-2_基，〗丨)，（Μ·938,丨丨，丨丨，Cl, 嘧啶-2-基，Cl), (Μ·939, 1 丨，丨 1，Cl,嘧啶-2-基，l·，)，（Μ·94()，Η，1丨，Cl. 嘧啶·2-基，CF.3), (Μ-ίΜΙ, II, II,(】1·吡唑-2-基）Br), (M-942, [[, Π, Cl. 嘧啶-2-基，CII3)，II，H, (〕l,嘧啶-4-基，Π)，（Μ·ί>44, Π, H, (〕1, 嘧啶-4-基，α), (Μ-ίΜΓ), Π, II, (〕l,嘧啶-4-基，Π, Π. Cl· 嘧啶-4-基，CF3), (Μ·947, 1U1, (】1,嘧啶-4-基，Br), (M-948, H, II，Cl, 嘧啶-4-基，CH3)，（Μ·ίΜ9, Η，ΓΙ, C 丨，嘧啶-5-基，Η), (M-950, II，H，Cl· 嘧啶-5-基，Cl), (Μ·951,丨丨，1丨，C1，嘧啶-5-基 > F), (Μ·{)52, ίΐ，Π, Cl, 嘧啶-5-基，CFs)，（Μ·9Γ)3,丨丨，丨丨，（】丨，嘧啶-5-基，Br)，（Μ-ί)Μ,丨丨，Η, Cl. 嘧啶-5-基，CH〇,（Μ·9Γ)5, Π，II，Cl, m)()(〕(〕lh(nUCH2, II)，（Μ·9^^
Cl. IIOOCCH2CH2CII2, Cl), (Μ-ί)57, II, H, Cl, IIC)()CCi[2CH2CIl2, F), (M-958, H. n. Cl, IIOOCCFI2CH2CII2, CP：〇, (Μ.ί)Γ)ί), II, II, Cl, IIOOCCH2CH2CH2, Hr), (M-960, II, H, Cl, ΗΟΘ〇ΟΠ2〇Ιΐ2(Ίΐ2, CII：〇, (M-i)Gl, II, H, CL HOOCCH2CH2CH2CII2, II), (Μ-ί)(；2, II, H, Ci, 11()()CC112C1I2CII2C1I2. Cl). (M-9G3. II, H, Cl, HOOCCn2CJl2(Mi2(Hi2, l〇, (Μ-ί)(Μ, Η, II, Cl, HOOCCll2CH2CH2CH2, CF：〇, (Μ-ί)(5Γ), II, II, Cl, 1IOOCCIΙ2ΟΗ2(：1ΐ2〇Η<>. Hr). (M.i)OG, H, H, Ci, IIOOCCH2CII2OII2CII2, CHm), (M-5)(57, II, H, Cl, (Me)2NCOCH2CH2CH2CIl2, H), (M-l)(58, ii, II, Cl, (Mo)2NCOCII2CII2CII2CH2. 1()() 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) 裝--------訂· # 1284639 A7 ______B7 ___ 五、發明說明（％ ) (請先閱讀背面之注意事項再填寫本頁)
Cl), (M-969, II, Π, Cl, (MeiaNCOCHaCIhClIaCHa, l〇, (M.D70, Η, II, Cl, (Me)2NCOCH2CH2CH2CH2, CF.3)，（Μ·971，II, H, Cl，（Me)2NCOCH2CH2CH2CH2. Br). (M-972, II, II, Cl, (Me)2NCOC!l2CU2Cil2CH2, Cila), (M-973, Η, H, Cl. (Me)2NCOCH2CH2CH2CH2CIl2, II), (M-f)74, Η, II, Cl, (Me)2NCOCIl2Cii2CIl2CH2CIl2, Cl), (Μ-ί)75, II, II, C\t (Me)2NCOCH2CH2CH2CIl2CIl2, F), (Μ-ί)70, Π, II, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CKr〇, (M-977, II, II, Cl, (Me)2NCOCH2CH2CIl2CH2CIl2, Br), (M-978, Π, Π, 〇l, 經濟部智慧財產局員工消費合作社印製 (Me)2NCOCH2CH2CH2CH2CIl2, Oil;»), (Μ-ί)7ί), II, H, Cl, M0OCII2, H). (M-5)80. Η, II, Cl, MeOCH2, Cl), (M-981, 11, H, Ci, M0OCH2, F), (M-982, II, H, Cl, MeOCH2, CF3), (M-983, II, H, Cl, M0OCII2, Hr), (M.{)84, II, II, Cl, M0OCII2, CII3), (M-985, Η, H, Cl, EtOCIh, II), (Μ-ί)86, II, II, Ci, E1OCH2, Cl), (M-987, II. H. Cl. EtOCH2, F), (M-988, II, H, Cl, EtOCIh, CFa), (M-989, Η, II, Cl, EtOCIl2, Br), (M-990, Η, H, Cl, EtOCIh, CIIm), (Μ-})ί)1, M, U, Cl, EtOCIhCIh, II). (M-992. Η, H, Cl, EtOCH2CH2, Cl), (M-99；], II, Π, Cl, ΚΙ〇0112〇1Ι2, F), (M-994, H, II, CL EtOCH2CH2, CF3), (M-995, Μ, II, Cl, Kt()C[l2〇lI2, Hr), (M-99G, Π, H. Cl. EtOCn2CH2, CII3), (M-997, II, II, Cl, Mo()CIl2CH2()CH2CH2, II), (Μ-ί)ί)8, II, II, Cl, MeOCH2CH2〇CH2CH2, Cl), (M-999, II, llj Cl M0OCII2CII2OCII2CII2, F), (M-1000, Η, II, Cl, MeOCH2CH2〇Cii2CU2, CK：0, (M-1001, Η, H, Cl, MeOClhCIhOClhClh, Br), (M-IOOU, Η, II, Cl, Μο()ΟΙΙ2〇1ΐ2〇ΟΙΐ2〇Ιΐ2, CILO， (M-1003, Η, II, Cl, MeOCIi2CIl2, II), (M-TOO^, II, Π, Cl, M0OCII2CH2, Cl), (M-1005, Η, H, Cl, MeOCIl2Cil2, F), (M-KKK), Μ, H, Cl, M0OCH2CH2, CFa). (M-1007, Η, II, Cl, MeOCH2CH2, Hr), (M-IOOH, II, II, Ci, M0OCII2CII2, CIl：^. (M-1009, Η, H, Cl, HOCH2, II), (M-1010, II, H, UOCII2, Cl), (Μ-10Π, Η. H,
Cl. HOCH2, F), (M.1012, H, II, Cl, IIOCII2, (M-1013, II, ll Cl. HOCH2,
Br). (M-1014, H, II, Cl, ilOClh, Clla), (M-IOIT), il, II, Cl, IIOCII2CII2, II), (ΜΙ 01 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 Α7 Β7 五、發明說明（、⑺） 1016, Η, II, Cl, HOCH2CH2, Cl), (M-i〇i7, II, H, Cl, HOCH2CH2, F). (M-1018, H. H. Cl. HOCH2CH2, CF3), (M-1019, H, U, Cl, 1100112〇112, Br), (M-1020, II, II, Cl, HOCH2CH2, CH3), (M-1021, n, Π, HOCII2CII2CII2, Η), (M-1022, II, H, Cl. UOCH2CII2CH2, Cl), (M-1023, H, H, d HOCII2CH2CH2, F), (M-1024, H, H, Cl, HOCIl2Cll2CH2, (M-1025, II, II, C\t llOCIUCIIaClla, Hr), (M-1()2(5, H, U,
Cl; HOCH2CH2CH2, CH3), (M-1027, Η, H, Cl, HOCH2CH2CH2CH2, Η), (M-1028. Η, H, Cl, HOCH2CH2CH2CM2, Cl), (M-l〇2i), II, II, Ci, IIOCH2CII2CH2CH2, F). (M-1030, Η, H, Cl, HOClUCAhClhCUz, CP：〇, (M-1031, II, H, Cl, HOCH2CH2CH2CH2, Br), (M-1032, Η, H, Cl, IIOCII2CH2CH2CH2, CH;〇. (M-1033, II, H, Cl, HOCH2CH2CIl2CIl2Cil2, II), (M-1034, Η, H, Cl, HOCH2CII2CH2CII2CH2, Cl), (M.1035, Η, II, Cl, IIOGH2CH2CII2CH2CH2, F), (M-1036, Η, II, Cl, HOCH2CII2CH2CH2CII2, CF3), (M-1037, Η, H, Cl, HOCH2CH2CII2CH2CH2, Br), (M.10；J8, II, II, Cl, HOCII2CH2GH2CII2CII2. CII3), (M-1039, Η, H, Cl, HOCH2CH2OCM2CH2, II), (M-1040, Η, H, Cl, HOCH2CII2OCH2CH2, Cl), (M-1041, H, II, CM, IIOCII2CII2OCII2CII2, F). (M-1042, Η, II, Cl, HOCH2CII2OCII2CII2, CFa), (M.1043, Η, H, Cl, HOCII2CH2OCII2CH2, Br), (Μ-ΠΜ4, Η, II, Cl, HOCIl2CH2〇CH2CH2, CHa). (M-1045, H, II, Cl, (Me)2N, II), (M-1046, Π, II, Cl, (Mo)2N, Cl), (M-1047, II, II, Cl. (Me)2N, F), (M-1048, II, II, Cl, (Mo)2N, CFa), (M-1049, Η, H, Cl, (Me)aN, Br). (M-1050, II, II, Cl, (Mo)2N, CH：〇, (Μ.1〇Γ)1, II, II, Cl, Ijg 0¾ - 4 - S ^ X , H), (Μ-10Γ)2, Η, H, Cl,哌啶-4-基甲基，Cl), (Μ-10Γ)3, Η, H，Cl,哌啶- 4-基甲基，F), (M-10Q4, H, H, Cl,哌啶-4-基甲基，（M-1055, H，H, Cl，哌啶-4-基甲基,_.Βί〇, (Μ·10Γ)(;，哌啶-4-基甲基 Clh)， (M-1057, Η, H, Cl,(環己基甲基，丨1), (M-1058, Η, H, (:1,(環己基甲基. Cl), (Μ·10Γ)9, il, H, Cl,(環己基甲基，Ρ)，（Μ·10(ί()，Η, 11, Cl, 環己基甲基，CF3)，（Μ·1()Γ)1,丨i· Π,(几環己碁甲基，Br)，（M-10G2, Η. 102 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注音？事項再填寫本頁) --------tr--------- 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 _ B7 ___ 五、發明說明) II· Cl·環己基甲基，CH.3)，（Μ·Κ)«3, Π, F，Η，Η, Η)，（Μ·ΗΚΜ，11，l·' ll· Η. Cl). (M-1065, H, F, H, II, F), (M-IOGC；, II, F, II, M, CFn), (M-1067, 11, F, II, 11, Br). (M-1068, II, F, Η, H, CH3), (M-10f59, II, F, II, F, U), (M.1070, II, F, II, F, Cl), (M-1071, H, F, H, F, F), (M-1072, II, K, Η, K, CFm), (M-1073, II, F, H, F, Br), (M-1074, II, F, U, F, CIIm), (Μ-Ι07Γ), II, l·1, II, Cl, II), (M-H)7(i, II, l\ II, Cl, (M), (M-1077, II, F, H, Cl, F), (M-1078, M, F, H, Cl, CF：〇, (M-1079, H, F, H, Cl, Br), (M-1080, H, F, II, Cl, CIIr〇, (M-1081, II, F, II, CAL·, Η), (M-1082, II, F, II, CH3, Cl), (M-1083, H, F, H, CHn, F), (M-1084, II, F, II, CAh. CFn), (M-1085. H. F, H. CAL·, Br), (M-1086, H, F, II, CHm, CIIm), (M-1087, II, F, II, Et, Μ), (M-1088. H, F, IL Et, Cl), (M-1089, H, F, II, Et, K), (M-1090, II, F, H, Et, CPs), (M-1091, II, F, H. Et, Br), (M-1092, H, F, H, Et, Clin), (M-1093, II, F, II, n-Pr, II), (M-1094, H, F. IL n-Pr, Cl), (M-1095, H, F, II, n-Pr, K), (M-1096, H, F, II, n-Pr, CF3), (M-1097, H, F, H, n-Pr, Br), (M-1098, II, F, II, n-Pr, Cll：〇, (M-1099, H, F, H. c-Pr. Η). (M-1100, H, F, H, c-Pr, Cl), (M-llOl, II, F, H, c-Pr, F), (M-1102, II, F, H, c-Pr, CFn), (M-1103, H, F, 11, cPr, Rr), (M-l t(H, II, K, H, c-Pr, CHa), (M-1105, H, F, II, i-Pr, Η), (M-1106, H, F, II, i-Pr, Cl), (M-1107, II, F, H, i-Pr, F), (M-1108. H. F, H, i-Pr, CF3), (M-1109, H, F, H, i-Pr, Br), (M-1110, H, F, H, i-Pr, CH3). (M-llll, H, F, II, n-Bu, II), (M-l 112, II, F, M, n-Bu, Cl), (M-1113, II, F, II, n-Bu. F), (M-1114, H, F, H, n-Bu, CK：〇f (Μ-Π Ιδ, H, F, II, n-Bu, Br), (M-1116, II. F. II, n-Bu, CHa), (M-1117, II, F, II, i-Hu, II), (M-1118, H, F, II, i-Bu, Cl), (M-1119, II, F, H, i-Bu, F), (M-1120, II, P, 11, i-Bu, CF：〇} (M.1121, II, F, II. i-Bu, Br). (M-1122. H, F, H, i-Bu, CII3), (M-U23, II, F, II, roc-Bu, II), (M-1124, II, F, H, sec-Βυ, Cl), (M-1125, II, F, II, roc-IUi, F), (M.112G, ii, F, H, soc-Bu, CF：〇. (M-1127, H, F, H, sec-Bu, Br), (M-112H, II, K, il, roc-Hu, Clla), (M.1129. 11. F. H. n-Fen, H), (M-1130, H, F, II, n-Pon, Cl), (Μ.11：Π, II, K, II, n-Pon, F), (M-1132. IL F, H, n-Pen, CF3), (M-113：}, II, U, n-Pon, Hr), II, F, II, n-Pon. 10：} 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注音？事項再填寫本頁) 裝--------訂---------^^^1. 經濟部智慧財產局員工消費合作社印製 1284639 A7 __B7__ 五、發明說明（P>) CH〇, (M-1135, H, F, H, c-Pon, II), (Μ-11；Η}, Π, F, U, c-Pon, Cl), (Μ-Μ；Π, Η, F, Η, c-Pen, F), (Μ-1138, Η, F, II, c-Pon, CKn), (M.1J39, II, F, II, c-Pen, Br). (M-1140, II, F, H, c-Pen, CH3), (M-1H1, H, F, H, n-Iiox, Η), (M-1H2, II, F, H. n-Hex, Cl), (M-1143, II, F, II, n-ilox, F), Π, K, H, n-Hex. CF3). (M-1145. U, F, II, n-llex, Br), (M-1146, II, F, II, n-llox, (M-1147, 11, F, II, c-Uox, 11), (M-1148, H, F, H, c-Hex, Cl), (Μ-1Ι4ί), II, F, H, c-Hox, F), (M-1150, H, F, H, c-Iiex, CF3), (M-1151, II, F, II, c-Ilox, Hr), (M-1152, II, F, II, c-IIox, CHa), (M-1153, H, F, H, OH, II), (M-1154, Hf F, II, OH, Cl), (M-1155, II, F, II, OH, F), (M-1156, H, F, H, OH, CF；〇, (M.1157, II, Π, Oil, Hr), (M-1158, H, F. II, OH. CHs), (M-1159, H, F, H, EtO, II), (M-IKH), H, F, II, KtO, Cl), (M-1161, II, F, H, EtO, F), (M-1162, H, F, H, EtO, CFn), (M-1163, H, F, H, EtO, Br), (M-1164, II, F, II, EtO, CH3), (M-1165, M, F, H, n-PrO, M), (M-llGG, II, F, II, n-PrO, Cl). (M-1167, H, F, H, n-PrO, F), (M-1168, II, F, II, π-PrO, CFa), (M-1169, H, F. H. n-PrO, Br), (M-1170, H, F, II, n-Pr(), CHa), (M-1171, II, F, II, PhO, Η), (M-1172, II, F, H, FhO, Cl), (M-1173, H, F, II, PhO, K), (M-1174, H, F, II, PhO. CFa). (M-1175, II, F, M, PhO, Br), (M-1170, II, F, II, PhO, Clin), (M-1177. II. F. H. BnO, H), (M-1178, H, F, H, BnO, Cl), (Μ-117ί), H, F, II, BnO, F), (M-1180, II, F. II, BnO, CF3), (M-1181, II, F, II, BnO, Br), (M-1182, H, F, II, BnO, CII；〇, (M-1183, H, F, H, PhCH2CH20, H), (M- i 184, II, P, H, PhCH2CH2〇, Cl), (M-1185. H, F, H, PhCH2CH2〇, F), (M-118G, II, l·1, II, PhCIbCIhO, CPa), (M-1187, II, F, 11. PhCH2CH2〇, Br), (M-1188, H, F, II, 1711011201120, CUa), (M-1189, II, F, H, CF3O. Η), (Μ·1190, II，F, H, CF3〇, Cl), (Μ·1191, 11, F，H，CFfl〇, F), (M-1192, H, F, H, CFnO, CF3), (M-1193, II, F, It, CKmO, Br), (M-1194, li, F, II, CFaO, CAL·), (M-1195, H, F, II, Ph, II), II, K, H, Ph, Cl), (M.lli)7, Η, K. II, Ph, F). (M-1198, H, F, II, Ph, CFr〇, (Μ-ΙΙί)ί), il, K, II, IMi, Hr), (M-1200, H, F, H, PK. CII3). (M-1201, H, F, H, 4-F-Ph, II), (M-1202, Η, K, 11, 4-F.Ph? Cl), (M-1203, H,
l(M 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公釐） -裝----- (請先閱讀背面之注意事項再填寫本頁) #· 經濟部智慧財產局員工消費合作社印製 1284639 A7 ___ B7___ 五、發明說明) F. II, 4-F-Ph, F), (M-1204, II, F, II, /l-F-Ph, CK：〇, (M-1205, H, F, IL 4-F-Ph, Hr), iM-1206, 11，F, H, 4-F-Ph，Crh), (Μ·12()7, 11，F, 11，4-Cl‘Ph，ίΐ), (M-1208· H. F· 1L 4-CF3-Ph, Cl), (M-1209, H, F, II, 4-CKvPh, F), (M-1210, H, F, II, 4-CFa-Ph, CF.3). (M-1211, H, F, H, 4-CFa.Ph, Hr), (M-1212, Η, K, H, 4-CF3.Ph, CH：〇. (M-1213, II, F, II, 4-(Me)2N-I)h, li), (Μ-i2Η, I!, K, II, 4.(Μο)2Ν·ΙΜι, CM), (Μ-Ι2ΙΓ), II, F? H, 4-(Me)2N.Ph, F), (M-1216, H, F, H, 4.(Mo)2N.Ph, CFa), (M-1217, H. F. H. 4-(Me)2N-Fh, Br), (M-1218, H, F, II, 4.(M(〇2N-Ph, CII3), (M-1219. II, F, Η, 1-OH-Ph, Η), (M-1220, II, F, H, 4-OII-Ph, Cl), (M-1221, H, F, II, 4-OIl-Ph, l〇. (M-1222, H, F, II, 4-OII-Ph, CF；〇, II, Π, /|-OU-Ph, Hr). (M-1224. H. F. H, 4-OH.Ph, CHa), (M-1225, Η, K, II, ；],4-cIi.F.Ph, Η), (M-1226, H, F, ll 3.4-di.F.Ph, Cl), (M-1227, II, F, 11, 3,4.(Ji.F.Ph, F), (M-1228, II, F, II, 3,4-cti. F-Ph, CF3), (M-1229, H, F, II, 3,4-di-F-Ph, Br), (M-1230, II, F, IL 3,4-di-F-Ph, CH3), (M-1231, II, F, II, 4-00011-141, Η), (M-1232, M, F, II, 4.C00H.Ph. Cl), (M-1233, H, F, II, 4-00011-1^, F), (M-1234, II, F, II, 4.C00HvPh, CF3), (M-1235, H, F, H, 4-COOH-Ph, Br), (M-123G, II, F, H, 4.C00HvPh, CHa), (M-1237, II, F, II, Bn, Η), (M-1238, II, F, H, Bn, Cl), (M-1239, II, F, H, Bn, F), (M-1240. H. F, H, Bn, CFs), (M-1241, II, F, II, Bn, Br), (M-1242, H, F, H, Bn, CHa), (M-1243, H, F, H, 4-F-Bn, H), (M-124^1, II, F, ll, Cl), (M-1245, II, F. H, 1- F-Bn, F), (M-1246, H, F, II, 4-F-Bn, CRm), (M-1247, II, F, H, 4-P-Bn, Br), (M-1248, U, F, II, 4-F-Bn, CH3), (M-124i), H, K, II, 2-Py, II), (M-1250, Π, F, II, 2-Py, Cl), (M-1251, II, F, II, 2-Py, F), (M-1252, II, F, U, 2-Py, CFa), (M-1253, H. F, II, 2-Py, Br), (M-1254, H, F, II. 2-Py, Glia), (M-12G5, H, F, H, 3-Py, Η), (M-1256. H, F, H, 3-Py, Cl), (Μ-12Γ)7, Μ, K, II, F), (M-1258, H, F, ll 3-Py, CF：〇. (Μ·12Γ)9, H，F, H, 3-Py, Br), (Μ·12Π(), H，F, II，：i-l、y· (〕lh), (Μ·12(;1, 11，F, U, 4-Py, H), (M-1262, II, F, H, 4-Py, Cl), (Μ-12(5；ί, Η, K, II, 4-Py, F), (M-12(>4, H, F, II, 4-Py, CFr〇, (M-1265, II, F, II, 4-Py, Hr), (M-l 2(5(5, H, l·：, H, 4-Py, CH；〇. (M- 105 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) ½裝
ΛΜΒ I Mmmt tmaw ϋ a^i ^ i 0 n 1_1 «^1 tmm0 I A7 1284639 ___B7_ 五、發明說明（、。斗） 12G7, H, F, II, 2-Th, II), (M-12G8, II, F, II, 2-Th, Cl), (Mvl2G9, II, F. II, 2-Th, F). (M-1270, II, F, H, 2-Th, CF3), (M-1271, II, F, II, 2-Th, Br), (M-1272, II, F, H, 2-Th，Clh), (M-1273, il, F, Η, ·νΐ% II), (M-127少 1U' H, 3.Th，Cl), (Μ-127Γ)， 裝----- (請先閱讀背面之注意事項再填寫本頁) F. H, 3-Th, F), (M-1276, H, F, II, 3-Th, CF:〇, (M-1277, H, F, H, 3-Th, Br), (M-1278, H, F, H, Cih), (Μ·127ί), H, l·1, H,吡唑-2-棊，II), (M-128(UI, 1Λ ^ 吡唑-2-基，Cl), (M-1281, Η, P，H,吡唑-2-基，F)，（Μ·1282, H, F, H， 吡唑-2-基，CF3)，（M-1283, 1 丨，l·' 丨丨，吡唑-2-基，Br), (Μ·1284, I丨，F，Π, 壯唑-2-基，Clh)，（Μ-128Γ), Η, K，H，吡唑-3-基，II)，（M.128G, 11, F，Η, 吡唑-3-基，Cl), (M-1287, 11，F,丨丨，吡唑-3-基/l·’)，（Μ·1288, H. F, Η， 吡唑-3-基，CF3), (Μ·1289, Η，Κ,[丨，吡唑-3-棊，Β〇, (Μ·1290, II, F，II, 壯唑-3-基，CH3), (M-1291, II，P, H,嘧啶-2-基，H)，（M-1292, H, F, Η, 嘧啶-2-基，Cl), (Μ·12ί)3, Η, K, H,嘧啶-2·基，F), (M-1294, H，F，Η, 瞭啶-2-基，CF:0, (Μ-129Γ)，11, Κ, H,嘧啶-2-基 I，lir)，（Μ-12ί)(;，H，F，Η， 嘧啶-2-基，CH3), (Μ·1297, Π, K, H,嘧啶-4-基，H)，（Μ-1298, H，F，11， 嘧啶-4-基，Cl), (M-1299, Η, K, Η, 1)嘧啶-4-基，l·’)·（M-1300, II, F, ίΐ， 喃啶-4-基，CF；〇, (M-1301，Π, K,丨 1，嘧啶-4-基，Br), (1VM;]02, II, F· H, 嘧啶-4-基，Clh)，（M-1303, H，l·’，Π，嘧啶-5·基，Η), (Μ·1304, [I, F\ 11， 嘧啶-5-基，Cl), (M-1305, 11，l·’，II，μ嘧啶-5-基，K), (M-130G, 11, F，11· 喃啶-5-基，CF3), (Μ·1307, 11，F，H,喷啶-5-基，I3r)，（M-1308, H, F，Η, 嘧啶-5-基，Clh), (Μ-1:Κ)ί)，11，l·' IUf()()(】(〕ll2ClhCH2, Η)， 經濟部智慧財產局員工消費合作社印製 H. HOOCCihClbCIh/Cl), (Μ.1：Π1, H, K, II, IIOOCCM2CH2CH2. F), (M-1312. H. F. II? HOOCCH2CH2CH2, CP：〇, (M-1；U3, II, K, ilf IIOOCCH2CII2CH2, Fir), (M-13H, II, F, H, IIOOCCH2CII2CII2, CIIm), (Μ-1；ΠΓ>, II, F, II, ΙΙΟΟ(；ΟΙΐ2〇Ιΐ2〇Ιΐ2〇Ιΐ2, H), (M-l：H(i, II, K, II, IKJiiCvOIIaClhCIhCll·^. (>1), (M-1317, 11，F, H, IK)OCCihClh(】lh(Uh，ΙΟ, (Μ·1Μ18, 11, F, 11， HOOCCIi2CH2CH2CIl2, CP3), (M-1311), il, F, II, IIOOCCU2CH2CH2CH2. Br), I Of； 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 1284639 A7 ___B7__ 五、發明說明) (請先閱讀背面之注音？事項再填寫本頁) (Μ-1320, H, F, Π, IIOOCCIl2CIl2CH2CIi2, CII：〇, (Μ-1321, II, F, II, (Me)2NCOCH2CIl2CH2CH2, Η), (Μ-1322, II, F, II, (Me)2NCOCll2CH2CIl2CH2. Cl)f (M-1323, II, F, II, (Me)2NCX)CiI2CH2CU2CII2, F), (M-1324, II, F, II, (Me)2NCOCH2CH2CH2Cfl2, CF〇, (Μ·132「)，H, F, H, (MekNCOCfhCIhCIhCIh· Ur), (M-1326, H, F, II, (Mo)2N(；〇CIhC：lla(JlI2, Clla), (M-l；}27, II, l·1, H, (Me)2NCOCH2CH2CH2CH2CH2, M), (M-1328, II, F, H, (Me)2NCOCH2CH2CH2CH2Ci[2, Cl), (M-132{), II, P, II, (Me)2NCOCH2CIl2CIl2CU2CIl2, F), (M-1：J：K), II, ΙΛ II, (Me)2NCOCH2CH2CH2CH2CH2, CF；i), II, K, II, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-1332, II, F, H, 經濟部智慧財產局員工消費合作社印製 (Me)2NCOCH2CH2CH2CH2CH2, CII：〇, (M-1333, II, F, li, MeOCIh, Η), (M-1334. H. F, II, MeOCH2, Cl), (Μ-133Γ), li, F, li, M0OCH2, F), (M-1336, II, F, H, MeOCH2, CF3), (M-1337, H, F, li, M0OCM2, Hr), (M-1338, II, F, H, MeOCIh, CHa), (M-1339, H, F, H, EtOClh, Μ), (M-1340, II, F, II, EtOCH2, Cl), (M-1341, H, F, II, EtOCH2, F), (M-1342, II, K, II, EtOCIh, CF：〇, (M-1343, H, F, IL EtOCH2, Br), (M-1344, H, F, II, Et()CH2, Clia), (M-1346, H, F, H, EtOCIhClh. Η). (M-1346, II, F, II, EtOCH2CH2, Cl), (M-1347, II, F, II, EtOCAUCAU, F). (M-1348, H, F, H, EtOCIhCih, CFm), (Μ-1；]49, Π, F, H, EtOCIhClh, Br). (M-1350, H, F, H, EtOCFhClh, CHn), (M-l；351, M, F, II, M0OCH2CH2OCII2CH2, H), (M-1352, II, F, II, MeOCH2CIl2〇C!l2CII2, Ci), (Μ-13Γ)3, H, F, H, MeOCH2CH2〇CH2CH2/F), H, F, II, M0OCH2CH2OCH2CH2, CFa), (Μ·13Γ)5, H, F, II, MeOCH2CH2OCH2Crh, Br), (M-1356, H，F，H， MeOCIl2CH2〇CII2CH2, CH：〇, (Μ-1：ΙΓ)7, II, ΙΛ II, M0OCH2CII2, II), (M-1358. II, F. II. M0OCH2CH2, Cl), (Μ.]：}Γ,ί), II, K, II, Μο()(ΜΙ2ΟΙΙ2ι l〇, (M-1；U；(), 11. F. 11, MeOCIi2CH2, CFs), (M-1361, Η, K, H, M0OCII2CH2, Hr), (M-1362, II, F, II, MeOCH2CH2, CHa), (M-13G3, II, K, II, IIOCII2, II), (M-1364, II, F, II, IIOCII2, 107 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 ___B7_ 五、發明說明（^ ) Ο), (Μ-1365, H, F, H, IIOCH2, F), (Μ-ΠΙΠΠ, U, ΙΛ II, IIOCH2, CF;〇. H, ill·——·-----%裝 (請先閱讀背面之注音？事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 F. H, HOCH2, Br), (M-1368, H, F, H, HOOih, CII3), (Μ·1369, H, F, II, HOCH2CH2, Η), (M-1370, II, F, Π, HOCIhOIh, Cl), (M-1371, II, F, II, HOCH2CII2, F), (M-1372, II, F, II, IiOGI^CIh, CFn), (M-1373, II, F, II, HOCU2CH2, Hr), (Μ-137Ί, II, K, II, ΙΙ〇(ΊhCIh, OII；i), (M-t；i75, II, h\ II, HOCII2CH2CH2, Η), (M-1376, H, F, H, UOCH2CH2CII2, Cl), (M-1377, H, F, H. HOCH2CH2CII2, F), (M-1378, II, F, H, 11()0112〇112〇112< CFa), (M-1379. II, F, II. HOCH2CH2CH2, Br), (M-1380, llf F, H, HOCII2CII2CH2, CHa), (M-1381, II. F. II. HOCII2CH2CH2CH2, H), (M-1382, Η, P, II, 11001120112〇112〇112> Cl), (M-1383. II. F, H, HOCII2CH2CH2CH2, F), (M-1384, II, F, II, IIOCH2CH2CH2CH2, CFa), (M-1385, II, F, H, IIOCH2CH2CII2CM2, Br), (M-1386, II, F, II, HOCH2CH2CH2CH2, CH3), (M-1387, M, F, H, IIOCH2CH2CH2CH2CH2. M), (M-1388, II, F, II, HOCH2CH2CII2CH2CII2, Cl), (M-1389, II, F, H, HOCH2CH2CH2CH2CH2, F), (M-1390, H, F, H, HOCII2CH2CH2CH2CH2, CF3), (M-1391，H，F, H, HOCIhCIhClisCIhCHs，Br), (Μ·1392, H, F, H, HOCH2CH2CH2CH2CH2, CII3), (M-J393, M, F, II, IIOCH2CH2OCH2CII2, H). (M-1394, II, F, H, IIOCII2CH2OCII2CII2, Cl), (M-131)5, H, F, II, HOCH2CM2OCH2CH2, F), (M.liU)G, 11, F, II, HOCH2CH2OCH2CH2, CF：〇, (M-1397, H, F, H, HOCH2CH2〇CH2CU2, Hr), (M.1398, II, F, H, HOCH2CH2OCH2CII2, CHa), (Μ.13ί)ί), II, K, II, (Mo)2N, II), (M-1400, II. F, H, (Me)2N, Cl), (M-1401, H； F, M, (Mo)aN, l〇, (M-1402, II, F, H, (Me)2N, CFs), (M-1403, 11, F, H, (Me)2N, Br), (M-1404, II, F, H, (Mo)2N, CHa), (M-1405, H, F. H，哌定-4-基甲基，II)，（Μ·1·，Η，K丨丨，哌啶基甲基，C1), (Μ·】407, H, F, Η,哌啶-4-基用基·，K), (M-H08,丨 1, 丨1,哌啶-4-基 甲基〗，CFr〇, (Μ-1409, II, F,丨丨，哌啶-4-基甲棊，I3r), (Μ-1410,丨丨，F, Η, 哌啶基甲基，〇丨切，（Μ·〗4】1，丨丨，K,丨丨，環己棊甲棊，H)，（M-Ul2. 108 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公釐） 1284639 A7 經濟部智慧財產局員工消費合作社印製 ___B7___ 五、發明說明) II. l·' 1丨，環己基甲基丨，Cl), (M-m·%丨丨，F,丨丨，環己基甲基，F)，（Μ· ]41(H,F, Η，環己基甲基，Ch), (Μ·141/3,Η, Ρ, Η,環己基甲基，Br), (M-141G, H，F, II，環己基甲基,（Μ·1417, 11, F, K, U，11)，（M-1418, II， F. F, H, Cl), (M-1419, H, F, F, II, F), (M-H20, ll F, F, H, CF3), (M-1421. II. F, F, H. Br), (M-1422, II, F, F, II, CII：〇, (Μ-Μ2：ί, II, ΙΛ K, P, II), (M-I42I, II, ΙΛ l\ F? Cl), (M-1425, H, F, F, F, F), (M-H2(5, II, F, F, F, CFa), (M-1427, H, F, F. F. Br)，（Μ·Η28, H, F, 1' F, CH3), (Μ·1 仏!)，II，ΙΛ ΙΛ (〕1, Π), (Μ·14:Κ), Π, ΙΛ F· Cl, (〕1). (M-H31, H, F, F, Cl, F), (M-H32, Μ, P, F, Cl, CF；〇, (M-1433, II, F. F, Cl, Br). (M-1434, II, F, F, Cl, CII3), (Μ-143Γ), 11, F, F, CII3, Η), (M-1436, II. F, F. CAU, Cl)? (M-1437, II, F, F, CH3, F), (M-H38, II, F, F, CHa, CFn), (M-1439, F, F, CII3, Br), (M-1440, H, F, F, CII3, ClI；〇, (M-H41, II, F, F, Et, Η), (M-1442, H, F, F, Et, Cl), (M-1443, H, F, F, Et, F), (Μ·\ΑΛΑ, II, F, F, Et, CFa), (M-1445, 1L F, F, Et. Br), (M-1446, II, F, F, Et, CH3), (M-H47, H, F, F, n-Pr, II), (M-1448, II. F. F. n-Pr, Cl), (M-1449, H, F, F, n-Pr, F), (M-1450, II, F, F, n-Pr, CF3), (M-1451, II, F, F, n-Pr, Br), (M-1452, H, F, F, n-Pr, CHa), (M-1453, II, F, F, c-Pr, H), (M-1454, M, F, F, c-Pr, Cl), (M-Hfifi, Π, F, F, c-Pr, F), (M-1456, II, F, F. c-Pr. CF3), (M-1457, H, F, F, c-Pr, Br), (Μ-ΗΓ)8, II, F, F, c-Pr, CM,3), (M-1459, II, F. F, i-Pr, Η), (M-1460, II, F, F, i-Pr, Ci), (Μ-Η(Π, II, K, F, i-Pr, F), (M-14G2, II. F, F. i-Pr, CF3), (M-1463, II, F, F, i-Pr, Hr), (M-1464, H, F, F, i-Pr, CH3), (M-1465. M, F. F, n-Bu, Η), (M-1466, H, F, F, n-Hu, Cl), (M-HG7, II, F, P, n-Bu, F), (M-1468, H? F, Ff n-Bu, CF3), (M-1469, H, F, K, n-Bu, Br), (M-1470, II, F, F, n-Bu, CH3). (M-1471, H, F, F, i-Bu, Η), (M-H72, 11, F, F, i-Bu, Cl), (M-1473, II, F, F, i-Bu, F), (M-H74, H, F, F, i-Βυ, CF.〇, (M-H75, II, K, F, i-Hu, Br), (M-147G. H, F. F. i-Ηυ, CH：〇, (M-1477, II, F, F, soc-Hu, 11), (M-H78, II, K, F, soc-Hu. Cl), (M-l 179, H. F, F, kcc-Bu, F), (M-1480, II, F, P, koc-Hu, CF；〇, (M-1481, H, F. F, roc-Bu. HrV (M-1482, II, F, F, sec-Bu, CHr〇, (M-HH,% II, F, F, n-Pon, Η), (M-1484, H, F, F, 105) (請先閱讀背面之注意事項再填寫本頁) _每裝
• ϋ ϋ .^1 I ϋ n -i_l 1-— ^1 ϋ ^1 ·ϋ ^1 I 訂 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 ------B7___ 五、發明說明 C|), (Μ-1485, H, F, K, n-Pon, K), (M-H8(5, Η, K, F, n-Pon, CF：〇, (M-l 187, P，F, n-Pen, Br), (M-1488, H, F, P, n-Pcvn, Clia), (M-1489, H, F, F, c-Pen. H). (M-1490, h, F, F, c-Pen, Cl), (M-1491, II, F, F, c-Pen, F), (M-1492, H, F, F, c-P^n, CF.3), (M-1493, H, F, F, c-Pon, Br), (M.H94, H, F, F, c-Pen, CH；〇, (M-1495. F? F, n-Hex, II), (M-149G, II, F, K, n-Hox, (Ί), (M.1497, II, V\ n-llox, l·1), (M.1498, II, F, F, n-IIex, CFn), (M.1499, H, F, n-Hex, Br), (M-1500, H, F, F. n-Hex, CH3), (M-1501, H, F, F, c-IIox, H), (M.1502, II, K, F, c-IIex, Cl), (M-1503. H? F, F, c-Hex, F), (M-1504, H, F, K, c-liox, CAh). (M-1B05, H, F, F, c-Hex, Br). (M-1506, H, F, F, c-Hex, CHa), (M-IG07, II, F, F, OH, Η), (Μ.1Γ)08. H. F. F, OH. Cl), (M-1509, H, F, F, OH, F), (Μ-ΙΠΙΟ, II, F, K, Oil, CFa), (M.1511, II, F, F, OH, Br), (M-1512, H, F, F, OH, CH；〇, (Μ-1Γ)13, II, F, F, KtO, Η), (M-1514, H. F. F, EtO, Cl), (M-1515, II, F, F, EtO, l〇, (M-ICIG, If, F, F, EtO, CF3), (M-1517, II. F, F, EtO, I3r), (M-1518, H, F, F, EtO, Cila), (M-1519, II, F, F, n-PrO, II)t (M-1520, H, F, F, n-PrO, Cl), (M-1521, H, F, P, n-PrO, F), (M-1522, II, F, F, n-PrO, CFa), (M-1523, H, F, F, n-PrO, Br), (M-1524, II, F, 1Λ n-PrO, CHa), (M-1525, H, F, F, PhO, II), (M-1526, H, F, F, PhO, Cl), (M-1527, 11, F, F, PhO, F), (M-1528, II. F. F; PhO, CFr〇, (M-1529, H, F, F, PhO, Mr), (Μ-ΙΓ)：Η), II, F, F, PhO, CHa). (M-15；M. II, F, F, BnO, Η), (Μ-1Γ332, U, F, F, Hn(), Ci), (Μ-153；ί, H, F, F, BnO. F), (M-1534, II, F, F, BnO, CF.〇, (M-1535, M, F, F, BnO, Br), (M-1536, II, F, F, BnO, CHa), (M-1537, II, F, F, PhCM2CIIiiO, II), (M-1538, H, F, F, PhClhCIhO, Cl). (M-1539, H, F, F, PhCthCIhO, F), (Μ-1Γ)40, II, F, F, PhCH2CH2〇, CFa), (M-1541. II, F, F, PhCH2CH2〇, Br), (M-1542, H, F, F, PhCU2CH2〇, CHa). (M-1543. H. F, F, CF3O, II), (M-1644, II, F, CF:»(), Cl), (M-l545, II, F, F, Cl^O, F), (M-15/16, H, F, F, CF；j〇, CFr〇, (Μ.|Γ,47, H, F, K, CFnO, Br), (M-1548, II, F. F. CFaO, CM3), (M-1549, II, F, F, Ph, II), (Μ.1Γ)Γ>(), II, F, l·1, Ph, Cl), (M-1551. H. F. F. Ph, F), (M-1552, II, F, F, Ph, CF：〇, (M.1553, II, K, F, Ph, Br), (Μ-15Γ34, H, F. (請先閱讀背面之注意事項再填寫本頁) 丨裝--------訂· f 經濟部智慧財產局員工消費合作社印製 1 10 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 _B7_ 五、發明說明) F, Ph, CH3), (M-1555, Η, F, F, d-F-Ph, II), (Μ-1Γ,Γ)β, H, F, F, 4-F.Ph. Cl). (M-1557, II, F, F, 4-F-Ph, F), (M-1558, 11, F, K, 4-F-Ph, CF,〇, (M-1559, II, F, F, 4-F-Ph，Br), (M-1560, H, F, F, 4-F-l)h, CH3)，（M]r》Gl, II, F, F, 4-ClVPh, 11), (M-15G2, H, F，F, 4-CIVPh, Cl), (Μ·1Γ)β3, II，F，F, 4-CFVPh, F)，（M-15G4, H，F· F. 4-CF.vPh, CF.i), (Μ-1Γ>0Γ), il, l·1, K, Hr), (Μ-ΙΓ>(；(!, II, l\ ΙΛ l-CKa-IMu CHa), (M-1567, H, F, F, 4.(Me)2N.Ph, II), (M-1G68, H, F, F, 4.(Me)2N-Ph, Cl), (M-15G9, H, F, F, 4.(Mo)2N.Ph, K), (M.1570, II, F, K, 4.(Mo)2N-Ph, CF：〇, (M-1571, II, F, F, 4-(Me)2N-Ph, Br), (M-1572, II, P, F, 4-(Mo)2N.Ph, CII；〇, (M-1573. H. F, F, 4.〇II-Ph, Η), (M-1574, H, F, F, 4-OII-Ph, Cl), (M-1575, H, F. F, 4-OH-Ph, F), (M-1576, H, F, F, 4-OM-Ph, Cl·^), (M-1577, II, F, F, 4-OII-Ph. Br), (M-1578, II, F, F, 4-OH-Ph, CII,〇, (M-1579, H, F, F, 3,4.di.F.Ph, H), (M-1580, H, F. F? 3,4-di.F-Ph, Cl), (M-1581, II, K, F, a^-di-F-Ph, F), (M-1582, H, F. F, 3;4-di-F-Ph, CF3), (M-1583, II, F, K, 3,4-di-F.Ph, Br), (M-1584, II, F, F, 3.4-di-F-Ph. CII3), (M-1585, H, F, F, 4-GOOU.Ph, Η), (M-1586, II, F, F, 4-COOH-Ph, Cl)，（Μ-1Γ)87, H, F, F, 4-COOn-Ph, l·’)，（Μ·1Γ)88, II, F, F, d-COOII-Ph, CF3), (M-1589, H, F, F, 4-COOII'Ph, Br), (Μ·1Γ)90, H, F，F，4-COOH-Ph, Clh), (M-1591, H, F, F, Bn, Η), (M-1592, II, F, F, Bn, Cl), (M-1593, H, F, F. Bn, F), (M-1594, II, F, F, Bn, CFr〇, (M.1595, II, F, K, Bn, Hr), (M-1596, H, F, F, Bn, CII3), (Μ·1597, H, F, F, 4-F-Bn, Η), (Μ·1Γ)98, H, F, l·’，4-F-Bn, Cl), (M-1599, H, F, F, 4-F.Bn, F), (M-1600, H, F, F, 4-F-Bn, CK〇, (M-1G01, II, F, F, 4-F-Bn, Br), (M-1602, H, F, F, 4-F-Bn, Clin), (M-l(503, il, F, F, 2-Py, !i), (M-1604, II, F, F, 2-Py. Cl). (M-1605, H, F, F, 2-Py, F), (M-IOOG, II, F, F, 2-Py, CFa), (M-1G07, II, F. F, 2-Py, Br), (M-1608, II, F, F, 2-Py, 0!!,〇, (Μ-ΚίΟί), II, F, F, ；3-Py, II), (M-1G10, IL F. F, 3-Fy, Cl), (M-1611, 11, F, F, ：Μ>, K), (M-1012, II, F, F, 3-Py, CF；〇. (Μ.11Π3. H, F. F. 3-Fy, Br), (M-1614, JI, F, l·1, CH：0, (Μ-ΚΠΓ), H, F, ΙΛ 4-Py. H). (M-1616, H, F, F, 4-Py, Cl), (M-1G17, II, P, F, 4-Py, F), (M-1618, H, F, F. 4-Py, 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ----1---------裝--------訂 _| (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五、發明說明（Π。） CF：3); (Μ-1619, Η, F, F, 4-Py, Hr), (M.1G20, Η, F, Κ, Ί-Py, Clla), (M-l(；2i, II, F, F. 2-Th, Η), (M-1622, H, F, F, 2-Th, Cl), (M-Ui23, 11, F, P, 2-Th, F), (M-1624. H, F. F. 2-Th, CF.3), (M-1625, II, F, F, 2-Th, Hr), (M-1626, H, F, F, 2-Th, CII3), (M-1627, II, F, F, 3-Th, Η), (M-1628, II, K, F, ；3-Th, Cl), (M-1629, H, F, F, 3-Th, F). (M-1G30, 11, F, F, ：1-Th, CK；〇, (M-KiiJI, II, K, l·1, M-Th, Mr), (M-I(；；i2, II, F, P, 3-Th，CH3), (M-1633, H, F, F,吡唑-2-基，H), (M-1G34, H, F, F，吡唑-2-基 ，Cl)，（M-1635, H，F, F,吡唑-2-基，l·，)，（Μ·1(ΚΚί, H, F, F,吡唑-2-基，Cl、)， (M-1637, II，F，F，p|t 唑-2-基，I3r), (M-1G38, H, F，F，吡唑-2·基，CH3), ίΜ·16·39, H, F, F,吡唑-3-基，11), (Μ·1(Μ(), H，l·' P，吡唑-3-基，（〕1).(1^· 1641, H, F，F,吡哩-3-基，l·’)，（Μ·1(Μ2, 11，F, l·’，吡唑-3-基，CF:〇,（Μ·1(Μ3, Η，F，F,吡唑-3-基，Br), (Μ·1644, II，Ρ，Ρ，吡唑-3-基，CH3)，（Μ-1(Μ5, II，F， F·嘧啶-2-基，Η), (M-1G4G, H，l·’，F，嘧啶·2-基，Cl)，（Μ·1(Μ7, H，F，F， 嘧啶-2-基，F)，（Μ·1648, Η, F, F,嘧啶·2·基，CFa), (Μ·1649, Η，F，F， 嘧啶-2-基，Br), (M-16fH), H, F, F,嘧啶-2-基，CH3), (M-1G51，II，F，F, 喃啶-4-基，H), (M-1G(32, Π, F, l·' 嘧啶-4-基，Cl), (M-1653, H，F，F, 嘧啶-4-基，F)，（Μ-16Γ)4, I丨，P, l·’，嘧啶-4-基，CFa), (Μ·Η555, II，F，F, 嘧啶-4-基，Br), (Μ·16/5Γ), H, F, F,嘧啶-4-基，Clh)，（M-1G57, H，F, F\ 嗤啶-5·基，Η), (Μ-1(;Γ)8, II，F，l·’，嘧啶-5-基，CD，（Μ·1(；Γ)ί)，H，P，l·' 嘧啶·5·基，F), (M-1660, H, F, l·1,嘧啶-5-基，CF3), (M-1GG1，H, F，F， 嘧啶-5-基，Br)，（Μ·1662, I丨，l·' F，嘧啶-5-基，Clh)，（M-1GG3,丨I，F，l?， HOOCCH2CH2CH2, H), (M-1G64, II, F, F, IIOOCCII2CH2CH2, Cl), (M-1665, H. F. F, IIOOCCH2CH2CH2, F), (M-UHIG, II, K, l·1, HOOCCIhCIhClh, CFa). (M-16G7, II, F, F, IIOOCCII2CH2CII2, Hr), (M-1(5(58, II, ΙΛ F, IIOOCCII2CH2CH2. CH；〇, (M-1669, H, F, F, ΙΙΟΟΟΟΙΙ2(Πΐ2〇ΙI2CU2, II), (M.1G70, H, ΙΛ F, HOOCCH2CH2CH2CH2, Ci), (M-1(571, It, ΙΛ l·1, ΙΙ()()ΟΟΜ2〇Π2〇Ιΐ2〇1ΐ2. F), (M-1672, H, F, F, HOOCCII2CH2CII2CII2, CK：〇, (M-l(；7；]t H, F, F, 112 本紙張尺度適用中國國家標準（CNS)A4規格（210x 297公釐） (請先閱讀背面之注咅？事項再填寫本頁) 裝--------訂--------- 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 ___B7___ 五、發明說明（“1 ) HOOCCII2CH2CH2CH2, Br), (M-H574, Μ, K, F, HOOCCH2CII2CII2CII2. CAL·), (M-1675, H, F, F, (Me)2NCOCIl2CH2CII2CIl2, Η), (M-1676, II, F, F, (Me)2NCOCH2CH2CH2CH2, Cl), (M-1677, II, F, F, (Me)2NCOCU2Cll2Cll2Cll2, F), (M-1G78, H, F, F, (Mo)2NCOCI[2CIl2〇ll2CH2, CF：〇, (M-1G79. ΙΪ. F, F. (Me)2NCOCll2CIl2CH2CH2, Br), (M-1G80, II, K, K, (Mo)2NCOCll2Cll2(Mb(3H2, CII3)· (M-1681，H, F, F, (Me)2NCO(〕IhCIhC：n2CH2CIi2, H)，（M-1682, 11，F, F· (Me)2NCOCIi2CH2CH2CH2CH2, Cl), (M.l(}8：3, II, F, F, (Me)2NCOClI2CH2CH2CH2CH2, F), (M.lfiHl H, F, l·’， (Me)2NCOCH2CH2CIl2CH2CFl2, CKm), (Μ-Η58Γ), II, K, P, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-1686, II, F, F, (Me)2NCOCH2CH2CH2CH2CH2, Clin), (M-K587, II, F, F, M0OCII2, II). (M-1G88. II, F, F, MeOCIh, Cl), (M-U589, Μ, K, F, M0OCII2, F), (M-1690, M, F, F, MeOCII2, CFs), (M-1691, H, F, F, MeOCII2, Br), (M-1692, H, F, F, MeOCH2, CH3), (M-1693, H; F, F, EtOCIIa, H), (M-1694, II, F, F, EtOCIh, Cl), (M-1695, H, F, F, EtOCH2, F), (M-1696, H, F, K, EtOCIl2, CP：〇, (M-1697, II, F, F, EtOCII2, Br), (M-1698, II, F, F, EtOCIi2, C!I,〇, (M-lGOi), II, K, F, EtOCH2CIl2, Η), (M-1700. H, F, F, EtOCIhCIh, Cl), (M-I7»i, 11, K, F, EtOCH2CIl2, F), (M-1702, H. F. F, EtOCH2CH2, CF3), (M-1703, 11, F, F, EtOCH2Cll2, Br), (M-1704, H, F. F, EtOCH2CH2, CHs), (M-1705, H, F, F, M0OCH2CII2OCH2CH2, II), (M-1706, H. F. F? MeOCH2CH2〇CH2CH2, Cl), (M-1707, II, F, F, M0OCII2CIUOCU2CU2, F), (M-1708, II, F, F, MeOClUClhOCU^Cll^ CFn), (M-1709, II, F, F, MeOCH2CH2〇CH2CH2, Br), (M-1710, H, F, F, M0OCU2CH2OCII2CH2, CH3). (M-1711, Π, F, F, MeOCH2CH2, II), (M-1712, II, F, F, M0OCII2CH2, Cl), (M-1713, H, F, F, MeOCH2CH2, F), (M-17M, II, F, K, M0OCII2CII2, CFa), (Μ-171Γ), II. F. F, M0OCII2CH2, Br), (Μ-171Π, II, ΙΛ K, MoOCIhCHa, CH；〇. (M-1717, II. F, F. HOCIh, Η), (M-1718, Η, P, F, IIOCU2, 〇D，(Μ-17Π), H, F, F, IIOCII2. F), 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ----1---.-----裝--------訂----- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五、發明說明) (M-1720, II F, F, HOCH2, CF；〇, (M-1721, II, F, F, UOCII2, Br), (M-1722, H. F, F. HOCH2, CII3), (M-1723, H, F, F, IIOCII2CH2, 11), (M-1724, H, F. F. HOCH2CII2, Cl), (M-1725, Η, P, K, HOCII2CII2, F), (M-172G, H, F, F, IIOCII2CII2, CFs), (M-1727, II, F, K, ilOCIhCIh, Br), (M-1728, H, F, F, HOCH2CH2, Clh), (M-1729, II, K, K, IIOCII2CIiaCII2, II), (M-I7；H), II, b\ ΙΛ HOCH2CH2CH2, Cl), (M-1731, H, F, F, HOCII2CH2CH2, F), (M-1732, H, F, F, HOCH2CH2CH2, CF.3), (M-1733, U, F, K, Η()ΟΙΐ2〇Η2〇Ιΐ2, Br), (M-1734, IL F. F. HOCH2CH2CH2, CH3), (M-1735, II, F, P, HOCII2CII2GII2CH2, Η), (M-1736, II. F. F, HOCH2CH2CH2CH2, Cl), (M-1737, II, F, F, IIOCH2CH2CH2CII2, F), (M-1738. H, F. F, IIOCH2CH2CH2CII2, CF：〇, (M.1735), II, F, F, ΗϋαΗ2〇Ιΐ2〇Ιΐ2〇Ιΐ2, Hr), (M-1740, II, F, F, HOCH2CII2CH2OM2, CH,〇, (M-1741, II, F, F, HOCH2CH2CH2CH2CH2, H), (M-1742, II, F, F, HOCH2CH2CH2CH2CH2, Cl), (M-1743, II, F, F, HOCH2CH2CH2CH2CII2, l〇, (M-1744, II, F, F, HOCH2CH2CH2CH2CH2, CFa), (M-1745, II, F, F, n〇CH2CH2CH2CH2CH2, Br). (M-1746, II, F, F, HOCH2CH2CH2CII2CH2, CMa), (M-1747, II, F, F, IIOCII2CH2OCH2CH2, H), (M-1748, H, F, K, iIOCH2CIl2〇CIl2CH2, Cl), (M-1749. H. F, F, IIOCIl2CIl2〇CH2Cll2, F), (M-1750, II, K, F, ΜΟΟΙΐ2〇Ιΐ2〇ΟΙΐ2〇Π2, CFa), (M-1751, II, F, F, HOCihClhOClIaCiia, Hr), (M-1752, II, F, F, HOCH2CH2OCH2CH2, CH3), (M-1753, II, K, (Mo)2N, Η), (M-1754, II. F, F. (Me)2N, Cl), (M-1755, II, F, F, (Mo)2N, l〇, (Μ-17Γ>(；, II, F, F, (Mo)〇N, CF；〇. (M-1757, II, F, F, (Me)2k, Br), (M-1758, M, F, P, (Mo)2N, CH3), (M-1759, H, F. F, 哌啶-4 基甲基，Η), (Μ·17β(),Η, F, F，哌啶-4 ·基甲基，(3丨)，（1^-17(51，1丨，丨'1?,哌啶-4-基甲基，丨'(1^-17似，丨丨^，哌啶-4-基 甲基，CF：〇,（M-17G3, II，P, F,哌啶-4-基甲基，以)，（Μ·17(Μ，H，F，F， 峨啶-4-基甲基，CH3)，（Μ·17⑽，丨丨，F, R環己基甲基，11)，（M-17GG, H, F，F，環己基甲基，Cl), (Μ·Ι7(}7,丨丨，K,環己基甲基，F). (M-17G8.
1H 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公釐） ill·---------•裝 (請先閱讀背面之注意事項再填寫本頁) 訂· 經濟部智慧財產局員工消費合作社印製 1284639 Δ7 Α7 _ Β7 五、發明說明（"）） II，F. F，環己基甲基:，CFV), (Μ·17ϋί)，H，l·’，F,環己基甲基丨，〜)，_· 1770, H, F, F，環己基甲基:，（:Π:ι)，（Μ·1771，H, F, Cl, Η, H)，（M-1772, H，F， Cl. Η, Ο), (Μ-1773, II, F, Cl, Η, F), (Μ-1774, II, ΙΛ CI, Η, CFa), (Μ-1775, Η, F, C1. Η, Br), (Μ-1776, Η, F, C1, Ιί, Clin), (Μ-1777, Η, F, Cl, F, Η), (Μ-1778. Η. F.
Cl. F. Cl), (Μ-1779, Η, F, Cl, Ρ, F), (Μ.1780, 11, V\ CM, ΙΛ ΟΙΛ·〇, (Μ-1781, 11, ΙΛ CM, F, Br), (Μ-1782, Η, F, Cl, F, CHa), (Μ-1783, II, F, Cl, C1, Η), (Μ-1784, Η, F, C1. Cl，C1)，（Μ·1785, Η, F, Cl, Cl, F), (M'17m;，Η, F, (〕l, Gl, Cl、)，（Μ-1787. II, C1,
Cl, Br), (Μ-1788, H, F, Cl, Cl, Clin), (M-178S), II, F, Cl, CHa, Π). (Μ-1790, Η, F.
Cl, CII3, Cl), (Μ-1791, Η, F, Ci, CIIm, F), (Μ-1792, Μ, F, Ci, CHn, CF：〇. (Μ-1793. Η; F, Cl, CHs, Br), (Μ-1794, II, F, Ci, CHa, CII3), (Μ-1795, II, F, Cl, Et, Η), (Μ-1796, II, F, Cl, Et, Cl), (Μ.17ί)7, II, F, Cl, Kt, F), (M-1798, II, F, Cl, Et, CF3), (M-1799, H, F, Cl, Et, Br), (M-IHOO, II, F, Cl, Kt, CUn), (M-1801, H, F, Cl, n-Pr, H), (M-1802, II, F, Cl, n-Pr, Cl), (M.1803, II, F, Cl, n-Pr, F), (M-1804, II, F, Cl, n-Pr, CF3), (M-1805, H, F, Cl, n-Pr, Br), (M-1806, 11, F, Cl, n-Pr, CHa), (M-1807, H? F, Cl, c-Pr, Η), (M-1808, II, K, Cl, c-Pr, Cl), (M-1809, II, F, Cl, c-Pr, F), (M-1810, II, F, Cl, c-Pr, CF3), (M-IBil, tl, F, Cl, c-Pr, Br), (M-1812. H. F, Cl. c-Pr, CH.3), (M-1813, II, F, Cl, i-Pr, II), (M-1814, II, F, Cl, i-Pr, Cl), (M-1815, H, F，Cl，i-Pr, F)，（M-1816, H, F, CU4)r, Ch), (Μ·1817, H，F, Cl，i-Pr，Br〇, (M-1818, H, F, Cl, i-Pr, CH3), (M-18H), H, F, Cl, n-Bu, Η), (M-1820, II, F, Cl, n-Bu, Cl), (M-1821, II, F, Cl, n-Bu, F), (M-1822, II, F, Cl, n-Bu, CF；〇, (M-1823, II. F, Cl, n-Bu, Br), (M-1824, H, F, Cl, n-Bu, CHa), (Μ-182Γ3, H, F, Cl, i-Bu. Η), (M-1826, H, F, Cl, i-Bu, Cl), (M-1827, IJ, F, Cl, i-Bu, F), (M-1828, H, F, CK i-Bu, CFa), (M-1829, II, F, Cl, i-Bu, Br), (M.18：)0, H, F, Cl, i-Bu, CHa), (M-1831, II, F. Cl. bcc-Bu, II), (M-1832, II, F, Cl, boc-Hu, Cl), (M-1833, II, F, Cl, soc-Hu, F), (M-1834, II, F, Cl, sec-Bu, CFa), H, F, Cl, hoc-Bu, Hr), (M-18：U>. II, F
Cl, sec-Bu, CII3), (M-1837, H, F, ΟΙ, n-Pon, H), (M-1888, II, F, Cl, 11-Pon, Cl), I 15 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） (請先閱讀背面之注意事項再填寫本頁) 裝--------訂---------^^^1 · 經濟部智慧財產局員工消費合作社印製 1284639 A7 -—_ B7 五、發明說明（"4) ίΜ-1839, II F, Cl, n-Pen, F), II, K, Cl, n-Pon, CFa), (M-1841. H. F. Cl. n-pen, Br), (M-1842, H, F, Cl, n-Pon, Clin), (M-1843, H, F, Cl, c-Pon, Π), (M-1844, H, F, Cl, c-Pen, Cl), (M-1845, II, F, Cl, c-Pon, F), (M-1846, II, F, Cl, c-Pon, CF3), (M-1847, H, F, Cl, c-Pen, Br), (M.1848, M, F, Cl, c-Pon, Clh). (M-1849. H. ^ Cl, n-Hex, Η), (M-1850, Η, K, Cl, n*IJox, Cl), (M-18G1, H, F, Cl, n-llox, l〇, (M-1852, H, F, Cl, n-Ilex, CFa), (M-1853, II, F, Cl, n-IIex, Br), (M-1854, H, F, Cl, n-Hex, CHa), (M-1855, H, F, Cl, c-IIox, II), (M-1856, H, F, Cl, c-IIex, Cl), (M-1857, H, F, Cl, c-Hex, F), (M-1858, II, F, Cl, c-ilox, CF3), (M-1859, Π, F. Cl. c-Hex, Br), (M-1860, H, F, Cl, c-Hox, Clh)t (M-18G1, H, F, Cl, Oil, II), (M-18G2, Π. F? Cl, OH, Cl), (M-1863, H, F, Cl, OH, F), (M-1864, II, F, Cl, OH, CFs), (M-1865. H, F, Cl, OH, Br), (M-1866, II, F, Cl, OH, CHa), (M-1867, H, F, Cl, EtO, II), (M.18G8, II, F, Cl, EtO, Cl), (Μ-18(5ί), II, F, Cl, EtO, F), (M-1870, H, F, Cl, EtO, CF3), (M-1871, H, F, Cl, EtO, Hr), (M-1872, II, ΙΛ GI, EtO, CH3), (M-1873, II F. Cl, n-PrO, II), (M-1874, H, F, Cl, n-PrO, Cl), (M-1875, II, F, Cl, n-PrO, F), (M-1876, II, F, Cl, n-PrO, CFa), (MM877, H, F, Cl, n-PrO, Br), (M-1878, H. F, Cl. n-PrO, CH3), (M-1879, H, F, Cl, PhO, Η), (M-1880, II, F, Cl, PhO. Cl), (M-1881, H, F, Cl, PhO, F), (M-1882, II, F, Cl, PhO, CFn), (M.188IJ, II, F, Cl, PhO, Br), (M-1884, II, F, Cl, PhO, CM3), (M-1885, Π, F, Cl, BnO, Η), (M-1886. II, F. Cl, BnO, Cl), (Μ·1887, H, F, Cl, BnO, F), (Μ·1888, H, F, Cl, BnO, CF3)，（Μ·1889, H, F, Cl, BnO, Br), (M-1890, H, F, Cl, BnO, CH3), (M-1891, H, F, Cl, PhCH2CH2〇, Η), (Μ·1892, H, F, Cl, PhCH2CH2〇, Cl), (M-1893, H, F, Cl, PhCH2CH2〇, F)， (Μ·1894, H, F, Cl, PhCH2CII2〇, CF3), (M-1895, H, F, Cl, PhCH2CH2〇, Br)， (M-189G, H, F, Cl, PhCH2CH20, (〕1 切，（Μ·1897, H, 1，’，Cl, CF3〇, Η), (M-1898, 11， F, Cl, CF3O, Cl), (M-1899, II, K, Cl, CFaO, F), (M-IDOO, H, F, Cl, CF3O, CFa). (M-1901, H, F, Cl, CF3O, Br), (M.1f)02, II, K, 〇l, CFaO, CHa), (Μ-Π)03. II, F, Cl, Ph, Η), (M-1904, II, F, Cl, Ph, Cl), (Μ-ΙΟΟΓ), II, F, Cl, Ph, F), (M-1906, II, F, Cl. 11(5 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） (請先閱讀背面之注音？事項再填寫本頁) 裝--------訂· 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 __B7___ 五、發明說明.（〆）
Fh? CFr〇, (Μ-1907, Η, F, Cl, Ph, Br), (M.1908, II, F, Cl, Ph, CII3), (M-H)()9, H, F, CL 4-F-Ph, Η), (M-1910, II, F, Cl, 4-F-Ph, Cl)f (M-1911, H, F, Cl, 4-F-Ph. F), (M-1912, II, F, Cl, 4-F-Ph, CFn), (Μ.1ί)13, II, K, Cl, 4.K.Ph, Br), (M-1914, Η, ΙΛ Cl. 4-F-Ph, CHa), (M-1915, H, F, Cl, 4-CFa-Ph, H), (M-191G, H, F, Cl, 4-CF3-Ph, Cl), (M-1917, Uf F, Cl, l〇, (M-15)I8, 11, l·1, Cl, 4-(Μ^-ΙΊι, (M-li)li), H. F, Cl, 4.CF3.Ph, Br), (M-1920, H, F, Cl, 4-CF3-Ph, CHa), (M-1921, H, F, Cl, 4-(Me)2N-Ph, Η), (M-1922, H, F, Cl, 4.(Mo)2N-Ph, Cl), (M.1923, II, F, Cl, 4-(Me)2N-Ph, F), (M-1924, II, F, Cl, 4-(Mn)2N-Ph, CFn), (M-1925, Π, F, Cl, 4-iMo)2N.Ph, Br), (M-1926, II, P, Cl, 4.(Mo)2N-Ph, CMm), (M-1927, H, F. Cl. 1-OH-Ph, II), (M-1928, II, F, Cl, 4-OII.Ph, Cl), (M-1929, H, F, Cl, 4.〇HvPh, F), (M-1930, H, F, Cl, 4-OH-Ph, CF3), (M-1931, H, F, Cl, 4-OR.Ph, Br), (M-1932, H. F. Cl, 4-OII-Ph, Oils), (M-1933, II, K, Cl, 3,4-di-F-Ph, Η), (M-1934, II, F, Cl. 3?4.di.F.Fh, Cl), (M-1935, H, F, Cl, 3,4-(14.F-IMi, F), (Μ.1ί)36, H, F, Cl, 3,4-di-F-Ph, CFn), (M-1937, H, F, Cl, 3,4-di.F.Ph, Br), (M-1938, II, F, Cl, 3,4-di-F-Ph, CH3), (M-1939, II, F, Cl, 4-COOlI.Ph, Π), (M-1940, II, F, Cl, 4.C00II.Ph, Cl), (M-1941, H, F, Cl, 4.C00H-Ph, F), (M-1U42, II, F, Cl, 4.C00II.Ph, CFa), (M-1943, II, F, Cl, 4-COOH-Ph, Br), (M-1944, II, F, Cl, 4-COOH.Ph, CII3), (M-1945, H. F, Cl, Bn, Η), (M-1946, H, F, Cl, Bn, Cl), (M.1947, U, F, Cl, Bn, F), (M-1948, H. F, Cl, Bn, CFs), (M-1949, II, F, Cl, Bn, Hr), (M-1950, H, F, Cl, Bn, CH3), (M-1951, H, F, Cl, 4-F-Bn, H), (M-1i)62, U, K, Cl, 4-F-Bn, Cl), (M-1953, II, F. Cl, 4-F-Bn, F), (M-1954, II, F, Cl, 4-F.Bn, CF;〇, (M-1955, H, F, Cl, 4-F-Bn, Br), (M-1956, II, F, Cl, 4-F-Bn, CII3), (M-1i)r)7, Π, F, Cl, 2-Py, Η), (M-1958, H, F, Cl, 2-Py, Cl), (M-1959, II, F, Cl, 2-Py, l·1), (M-U)6(), II, F, Cl, 2-Py, CFn), (M-1961, H. F. Cl, 2-Py, Br), (M-1962, II, F, Cl, 2-Py, CII；〇, (M-IDO：], II, F, Cl, ；3-Py. II), (M-19G4, H, Ft Cl, 3-Py, Cl), (Μ.1ί)(；5, Π, K, Cl, 3-Py, !〇, (Μ-1ί)(5(5. II, F, Cl, 3-Py. CF：〇, (M-1967, II, F, Cl, 3-Py, Hr), (M-lOGfi, II, F, Cl, 3-Py, CII.〇, (M-HH59. 117 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) -------- 訂--------- 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五丨、猶fy(r (λ-1970, II, F, Cl, 4-Py, Cl), (M-1971, II, F, Cl, 4-Py, F), (M-1972, H, F, Cl, 4-Py, CF,〇, (M-I97；l, II, F, Cl, 4-Py, Hr), (Μ-1ί)74, H, F, CL 4-Py，dh), (M-1975, H, F, Cl, 2-Th, II), (M.U)76, II, F, Cl, 2-Th, Cl), (M-197T. H. F, Cl, 2-Th, F), (M-1978, II, F, (M, 2-Th, CF：〇, (Μ·1979, H, F, Cl, 2-Th, Br), (M-1980, II, F, Cl, 2-Th, CII：〇, (M-IOHI, II, K, CA, ；{.ΊΊι, II), (Μ.Ιί)Η2, II, K, ΓΙ, 3-Th, Cl), (M-1983, H, F, Cl, 3-Th, F), (M-1984, ii, F, Cl, 3-Th, CF3), (M-1985, H, F, Cl, 3-Th, Br), (M-198G, H, Cl, :3-Th, CLh), (Μ·1ί)87, H，F, Cl，吡唑-2-基 ，H)，（M-1988，H，F，C1,吡唑-2-基,CI),(M-li)8()，H, F, Cl,社唑-2-基，F)· (M-1990, H，F，Cl，吡唑-2-基，（〕丨、)，（Μ.ίίΜ)】，U, K, Cl，吡唑-2_基，Br), (M-1992, H, F，Cl，吡唑-2-基，Clia), (Μ·1ί)93, H, R Cl,吡唑-3-基i，II)， (Μ·19ίΜ，H，F，Cl,吡唑-3-基，Cl), (Μ·1995, H，F, Cl,吡唑-3-基，1)，（1^-1996, H，F，Cl，吡唑-3-基，Ch), (Μ·19ί)7, II，F, Cl,吡唑-3-基，13〇,(1\1-1998, 1丨，F，C1，吡唑-3-基，C丨切，（Μ·1ί)ί)ί),〖1，F, C丨，嘧啶-2-基，丨〖)，（矹· 2000, 1丨，F，C1，嘧啶 _2·基，（〕丨)，（M，20(U, ίί, P，Cl,嘧啶-2-基、F)，（M-2002, II，F，Cl,嘧啶-2-基 I，CPn), (Μ·2003, H，F，Cl,嘧陡-2-基，Br), (M-2004, H, F, Cl,嘧啶-2-基，(】Ηη)，（Μ·2()0δ，Π, F, Cl,嘧啶-4-基 3 Π). (M-200G，H, F, Cl，嘧啶-4-基，（〕1), (M-2007, II, F, Cl,喷啶-4-基，F), (M-2008, H, F, Cl,嘧啶-4-基，d), (Μ·2()09, II，F, Cl,嘧啶-4-基，Br), (Μ-2()10，Π, F，C1,嘧啶-4-基，(Μ·2()11,Ι丨，P, Cl,嘧啶-5-基，H), (M-2012, H，F, Cl,嘧啶-5-基，（】1)，（Μ·2013,丨丨，P，Cl,嘧啶-5-基 |，F)， (M-2014, H，F，Cl,嘧啶-5-基 3 (池)，（Μ·2()15, II，F，Cl,嘧啶-5-基，Br)， (M-2016, H, F, Cl,嘧啶-5-基，（」h), (Μ·2017, H，F, Cl, HOOCCIhClhCIh, Η). (M-2018, H, F, Cl, HOOCCIhCII2CH2, Ci), (M.2019, H, F, Cl, HOOCCII2CH2CH2, F), (M-2020, II, l·1, 01, IIOOCCIhClbCHa, CF：〇. (M-2021, II, F. Cl? IIOOCCII2CH2CU2, Br), (M-2022, II, K, Cl, II()OCCIl2CI[2Cll2, C\L·), (Μ·2()23, II, F, Cl, H()OCCH2CH2(〕li2(】lh, Η), (Μ·2()ίΜ, H，F，Cl， 1)8 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公釐） ----:---/------裝---- (請先閱讀背面之注意事項再填寫本頁) 訂i A7 1284639 ____B7___ 五、發明說明（"7) UOOCCH2CH2CH2CII2, Cl), (M-2025, II, K, Cl, HOOCGH2CH2CH2CH2, F), (M.2026, H, F, Cl, llOOCClUCAhCAl^CAl^ 〇ΙΛ〇, (M-2027, H, F, Cl, n〇OCCH2CH2CIl2CIl2, Br), (M-2028, Η, ΙΛ (儿 HOOCCH2CH2CH2Cn2, Cih), (M-2029, H, F, Cl, (Me)2NCOCH2CU2(m2CH2, Η), (Μ·2030, H, F, Cl， (Mo)2NCOCIl2CIl2CH2C!i2, Cl), (Μ-20：Π, II, ΙΛ (Ί, (Μη)ϋΝ(：0(ΊΙ^(ΊΙν,(ΊΙ·.5(Ί 1., F), (M-2032, H, F, Cl, (Me)2NCOCH2CH2CH2CH2, CFa), (M-2033, H, F, Cl, (Me)2NCOCH2CH2CH2CH2, Br), (M.2034, II, K, Cl, (Mo)2NCOCIl2CIl2Cll2CH2, CI13), (M-2035, H, F, Cl, (Me)2NCOC[l2Cn2CH2CH2GH2> Η), (M-2036, H, F. Cl. (Me)2NCOCIl2CH2CH2CIl2CH2, Cl), (M-2()：i7, U, F, Cl, (Me)2NCOCH2CH2CIl2CH2CH2, F), (M.2038, II, F, Cl, (Me)2NCOCH2CH2CH2CIl2CIl2, CFa), (M-2039, H, F, Cl, (Me)2NCOCH2CH2CH2CIl2CH2, Br), (M-2040, H, F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CIIm), (Μ-20Ί1, M, F, Cl, MeOCFh, Η). (M-2042. H, F, Cl, MeOCFh, Cl), (M.2043, Π, F, Cl, MeOCH2, F), (M-2044, II, F, Cl, MeOCIh, CF3), (M-2045, H, F, Cl, MoOGIia, Hr), (M-204G, H, F, Cl, MeOCfh, CH3), (M-2047, H, F, Cl, EtOCIh, Η), (M-2048, II, F, Cl, EtOCH2, Cl), (M-2049. II, F, Cl, EtOCH2, F), (M-2050, II, K, Cl, E1OCH2, CF3), (M-2051, H, F, Cl EtOCH2, Br), (M-2052, H, F, Cl, E(()CH2, Clin), (M-2053, II, F, Cl, E10CH2CH2, Η), (M-2054, H, F, Cl, EtOCIi2CIi2, Cl), (M-2055, II, K, Cl, EtOCH2CH2, F), (M-2056, H, F, Cl, EtOCH2CH2, 〇Kr〇, (Μ-20Γ)7, II, F, Cl, EtOCH2CH2, Br), (M-2058, H, F, Cl, EtOGH2CH2, CIIm), (M-2059, II, F, Cl, MeOCH2CH2〇CIl2CH2, Η). (M-2060, H, F, Cl, MeOClhClhOCAhClh^ Cl), (M-20G1, H, F, Cl, MeOCil2CH2〇CH2CH2, F), (M-20(i2, II, K, 〇l, M0OCM2CH2OCH2CH2, CFa). (M-2063, II, F, Cl, McOCII2Cil2〇C1，lI2CH2, Hr), (M-20(M, II, F, Cl, MeOCH2CH2〇CIl2CIl2> CHrO, (Μ.2(Κ55, H, F, Cl, Μο()ΟΙΐ2〇Η2, H), (M-20GG, II, F. Cl. MeOClhCIh, Cl), (M-2067, il, ΙΛ Cl ΜοΟΟΙΐ2〇Η2, F), (M-2068, H. F, Cl, 1H) 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ill·---.-----·%裝 (請先閱讀背面之注音？事項再填寫本頁) ^1 ^1 ϋ I 一：口 t —.1 ϋ 1_1 ϋ ϋ I - 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 ___ B7_____ 五、發明說明（"〇 M0OCH2CH2, CF.3), (M.2069, II, F, Cl, M0OCH2CU2, Hr), (M-2070, II, F. Cl. MeOCH2CH2, CHs), (M-2071, II, F, Cl, IIOCM2, Η), (M-2072, II, F, Cl, IIOCU2. Cl), (M-2073, fl, F, Cl, HOCH2, P), (M-2074, II, F, Cl, HOCH2, CFa), (M-2075, H, F. Cl, HOCH2, Br), (M-2076, II, F, Cl, IIOCH2, CMa), (M-2077, II, F, Cl, HOCH2CH2, Η), (M-2078, II, F, Cl, IlOClhCHa, Cl), (M.207S), tl· ΙΛ (M, HOCH2CII2, F), (M-2080, H, F, Cl, IIOCH2CH2, CF3), (M-2081, H, F, Cl, HOCH2CH2, Br), (M-2082, II, F, Cl, IIOCII2OH2, ClI：〇, (M-2083. H, F, Cl. HOCH2CII2CH2, H); (M-2084, II, F, IIOCH2CH2CH2, Cl), (M-2085, II, F, Cl. HOCH2CH2CH2, F), (M-2086, II, F, CAf UOCAUCAUCAU, CFa), (M-2087, II, F, Cl, HOCH2CH2CH2, Br), (M-2088, Η, K, Cl, HOCAUClhClh, CII3), (M-2089, II, F, Cl, HOCH2CH2CH2CH2, Η), (M-2090, Η, P, Cl, HOCH2CH2CH2CH2, Cl). (M-2091, H, F, Cl, HOCH2CII2CH2CII2, F), (M-2092, H, F, Cl, ΗΟΟΗ2〇Η2〇ΙΙ2〇Η2, CFa), (M-2093, H, F, Cl, HOCH2CH2CH2CU2, Br), (M-2094, H, F, Cl, HOCII2CH2CH2CH2, CH3), (M-209G, II, F, Cl, HOCH2GH2CH2CH2CH2, H), (M-2096, H, F, Cl, ΗΟΟΗ2〇Ιΐ2〇Ιΐ2(>Η2〇Ιΐ2, Cl), (M-2097, H, F, Cl, HOCH2CH2Cn2CH2CH2, F), (M,2〇{)8, il, l·' (M-2099, II, F, Cl, HOCihCF^CIhCIbCIli, Hr), (M.2100, II, F, Cl, HOCH2CH2CH2CII2CH2, CILi), (M.2101, M, F, Cl, HOCII2CH2OCII2CII2. H). (Μ·21()2, H, F，Cl，HOCH2ClI2()(〕ll2Cll2, Cl), (Μ·21ϋ3, H，F, Cl， HOCH2CH2OCH2CII2, F), (M-2KM, II, F, Cl, IIOCII2CH2OCH2CH2. CF：〇, (M-2105, H, F, Cl, HOCH2CH2OCH2CII2, Br), (M-2106, H, F, Cl, HOCH2CH2OCH2CH2, CH3), (M-2107, H, F, Cl, (Mo)2N, II), (M-2108, II. F. Cl, (Me)2N, Cl), (M-2109, II, F, Cl, (Mo)2N, l〇, (M-2110, II, F, Cl, (Mo)2M, CF：〇. (Μ-21Π, II, F, Cl, (Me)2N, Br), (M-2112, II, ΙΛ (M, (Mo)2N, CH：〇, H, F,
Cl,哌啶基甲基，丨丨)，（Μ·21Η,丨丨，P· (〕1, i哌啶-4-基甲塞，Cl)， (Μ-211Γ)，[I，F, C1，丨哌啶-4-基甲基，F)，（M-211G，II，F，Cl,嚒晚·4一 l2() 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ----L---·-----裝---- (請先閱讀背面之注意事項再填寫本頁)
訂_ I 經濟部智慧財產局員工消費合作社印製 1284639 Δ7 A7 _____ B7 五、發明說明（"？）
基甲基，CI〜)，（M-2117, II, F, (〕1，哌啶-4-基甲基 1，Br), (M-2118,丨I，F， C1,哌啶· 4 -基甲基，（〕1切，（Μ·21丨9,丨丨，P, Cl?環己基甲基丨，1丨)，^· 2120. H，F，C1，環己基甲基 i,(】Ι)，（Μ·2121,丨 1，F，C1, I 環己基甲基 l，F)， (M-2122，H，F，C1，環己基甲基丨，（〕F3), (Μ·2123，Η, (】1,環己基甲基 L
BrMM-2124, li, F, CI, < 環己基甲基，（】ΙΙ·»)，（Μ-212Γ), II，（川·μ, II，II，II)， (Μ-2126, II, Oils, Η, H, Cl), (Μ-2127, Η, CHa, Η, Η, F), (Μ-2128, Η, CH3, Η, Η, CF.O, (Μ-2129, II, CHa, II, II, Br), (M.21；l(), II, Clla, Η, II, Clla), (Μ-2131, Η. CH.3, Η, F, Η), (Μ-2132, Η, Clio, Η, Κ, Cl), (Μ-2133, Η, CHs, Η, F, F). (Μ-2134. Η. CH3, Η, F, CF.3), (Μ-2135, Η, CIIm, II, Κ, Hr), (Μ.2ί；36, Η, Clla, II, F. CH；0. (Μ-2137, Η, CHs, Η, C1, Η), (Μ-2138, II, Clin, II, Cl, Cl), (Μ-2139, Η, CHa, II, Cl, F). (Μ-2140, H, CH3, II, Cl, CF3), (M.2141, H, CHa, H, Cl, Br), (M-2142, H. CII3, H, Cl, CH3), (M-2143, II, CH.3, H, Clin, II), (M-2144, H, CHa, II, Gila, Cl). (M-2145, llt CII3, H, CHs, F), (M-2146, II, CII,% H, Gila, CFa), (M-2147, H, CII3, II, CHa, Br), (M-2148, H, CHa, H, CHn, CHa), (M-2H9, H, GH3, H, Et, Η), (M-2150, H, Clh, II, Et, Cl), (M-2151, II, CHa, II, Kt, F), (M-2152, H, CHa, II, Et, CF3), (Μ·21Γ)3, H, CH3, H, Et, Br), (Μ·21Γ)4, H, H，Et，CH3), (Μ-21Γ)Γ), H· Clli H, n-Pr, II), (M-2156, II, CII3, II, n-Pr, Cl), (M-2157, H, CII3, II, n-Pr, F), (M-2158, H, CII3, H, n-Pr, CF3), (M-2159, H, CHa, II, n-Pr, Br), (M-2160, H, CII3. H, n-Pr, CH,〇, (M-2161, H, CHs, M, c-Pr, II), (M-21G2, II, CMa, II, c-Pr, Cl), (M-21G3, H, CHa, II, c-Pr, F), (M-2164, II, CIl；3, II, c-Pr, CFa), (M-2165, II, CH3, H, c-Pr, Br), (M-2166, H, CH3, H, c-Pr, CHa), (M-2167, II, CH3, H, i-Pr, Η), (M-2168, H, CH.3, H, i-Fr, Cl), (M-2169, H, CHa, II, i-Pr, F), (M-2170, H, Clh, II, i-Pr. CF3), (M-2171, H, CII3, II, i-Pr, Br), (M-2172, II, CUa, II, i-Pr, CHa), (M-2173, II. CAL·, II. n-Bu, Η), (M-2174, II, Cila, II, n-Hu, Cl), (M-2175, H, Clla, II, n-Bu, K), (M-2176, II, CH.3, H, n-Bu, CK：〇, (M-2177, II, Oil,II, n-Bu, Br), (M-2178. H. CHs, IL n-Bu, CH；〇, (M-2179, H, CMa, H, i-Bu, II), (M-2180, II, CII3, H, i-Bu, m 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ----1-----裝----- (請先閱讀背面之注意事項再填寫本頁)
^1 1^1 ϋ I eammm ϋ .1 1 mmmK mmme I I 訂 經濟部智慧財產局員工消費合作社印製 1284639 A7 ___B7___ 五、發明說明（^)
Cl)，（M-218】，H, CH·% II, i-Bu，F)，（M-2182, Π, Cn〜II，i-Bu, CIW，（Μ-2183· Π， CH3, H, i-Buf Br), (M-2184, H, Clla, II, i-Hu, CUa), (M-2185, H, Clla, H, soc-Hu. II). (M-2186, II, CII3, H, sec-Bu, Cl), (M-2187, II, Clin, II, sec-Bu, F), (M-2188, H. CII3, II, sec-Bu, CFa), (M-2189, II, GHa, II, sec-Bu, Br), (M-2190, H, CHs, FI, b(3〇Bu, (；II；〇, (Μ-21ί)1, II, Cila, II, n-INui, II), (M-2li)2, H, (Mia, II, n-l'on, C\), (M-2193, H, CH3, H, n-Pen, F), (M-2194, H, CH3, H, n-Pen, CFa), (M-2195, li, CII3, II, n-Pen, Br), (M-2196, H, Clla, 11, n-Pon, Ciln), (M-2197, II, CII3. II, c-Pen, Η), (M-2198, II, CH3, II, c-Pon, Cl), (M-2199, II, CII3, H, c-Pon, F). (M-2200. H. CII3, II, c-Pen, CF3), (M-2201, Ht Oil,% il, c-Pon, Br), (M-2202, H, Clla, H. c-Pen, CHa), (M-2203, H, CII3, II, n-Hox, Η), (M-2204, II, CHa, II, n-IIex, Cl), (M-2205, H, CH3, H, n-Hex, F), (M-2206, H, CII3, H, n-Hox, CFa), (M-2207, H, CH3, II, n-Mex, Br), (M-2208, II, Clin, II, n-Hox, CII：〇, (M-2209, II, Clin, H. c-Hex, Η), (M-2210, II, CII3, H, c-IIox, Cl), (M-2211, II, CHa, H, c-IIox, F), (M-2212, II, CH3, H, c-Hex, CF3), (M-2213, H, CHa, H, c-ltex, Br), (M-2214, H, CII3. H，c-Hex，CII3), (M-2215, H, Clh, H, OH, Γ1), (M-2216, H, CII3, H, OH, Cl), (M-2217, H, CH.3, H, OH, F), (M-2218, II, CII3, II, OH, CF3), (M-2219, Π, CAL·, II. OH, Br), (M-2220, II, CII3, II, Oil, CII：〇, (M-2221, II, CHa, II, EtO, II), (M-2222. H, CH.3, II, EtO, Cl), (M-2223, II, CMn, II; litO, F), (M-2224, H, CII3, H. EtO. CF3), (M-2225, H, CII3, H, EtO, I3r), (M-2226, II, CHa, II, EtO, CII3), (M-2227, II, CH3, H, n-PrO, Η), (M-2228, H, CMm, H, n-PrO, Cl), (M-2229, II, CH3, H, n-PrO, F), (M-2230, II, CH3, H；n.PrO, CF：〇, (M-2231, II, CHn, II, n-PrO, Br), (M-2232. H, CH3, H, n-PrO, CH3), (M-22；33, II, CM.% H, PhO, Η), (M-2234, II, 011:^ II, PhO, Cl), (M-2235, II, CII3, II, PhO, F), (Μ.22：Ηί, II, CH：u II, PhO, CF：〇. (M-2237. H. CII：3, H, PhO, Br), (M-2238, II, CIIm, il, PhO, CII：〇, (M-2235), ll, Clin. II, HnO, 11). fM-2240, II, CII3, H, BnO, Cl), (M-2241, H, CHa, H, BnO, F), (M-2242, It. CII3. H. BnO? CF3), (M-2243, H, CHn, H, BnO, Hr), (M-2244, H, CHa, II, BnO, CH：〇. 122 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 一裝—— (請先閲讀背面之庄意事項再填寫本頁) 1_| |_1 1 ^1 ^ r ϋ I I i_i -I 1 訂 A7 1284639 ___m__ 五、發明說明) (M-2245, H, CII3, H, PhCH2CH2〇, II), (Μ-2246, II, Clh, Η, PhCIhCIhO, Cl), (M-2247, H, CII3, H, PhCH2CH20, l〇, (M-2248, II, Cll3, 11, PhCH2Cll2〇. CF3), (M-2249, H, CHa, H, PhCIl2CH20, Hr), (M.2250, II, Oils, II, PhCIhClhO, CIl；〇, (M-2251, H, CH3, H, CF3O, H), (M-2252, H, CAhy H, CFaO, Cl), (M-2253, H, CHs, H, CF：iO, F), (M-2264, H, CIIm, II, CKmO, CKm), (Μ-22Π5, II, (ίΙΙ.ι, II, ΓΚΜ), Hi). (M-2256, H, CHs, H, CFaO, CH.s), (M-2257, H, CH3, H, Ph, Η), (M-2258, H, CH3, ll, Ph, Cl), (M-2259, H, CII3, II, Ph, K), (M-22G0, Jl, Clht H, Ph, CF：〇, (M-22G1. H. CH3, H, Ph, Br), (M-2262, H, CHa, H, Ph, CHn), (M-2263, H, CHa. II, 4-F-Ph, Η), (M-2264, H, CHs, H, 4-F-Ph, Cl), (M-2265, H, Clla, II, 4-F-Ph, F), (M-2266. H, Clh, H,心F-Ph, CF3), (M-22G7, Π, Br), (M-22G8, 11，Clh，11， 4-F-Ph, CH3), (M-2269, H, CIU, H, 4.CFn-Ph, II), (M-2270, II, CII3, II, 4-CF^ Fh, Cl), (M-2271, II, CH3, H, 4-CF3-Ph, F), (M-2272, H, CU3, II, 4-CF.s-Ph, CF；0. (M-2273, H, CH.3, H, 4-CF3-Ph, Br), (M-2274, II, Clin, H, 4-CF3-Ph, CII：〇, (M-2275, II, CII3, H, 4-(Me)2N-Ph, Η), (M-2276, II, CHa, H, 4.(Me)2N-Ph, Cl), (M-2277, H, CII3, H, 4.(Me)2N-Ph, F), (M-2278, II, CHa, H, 4-(Mo)2N-Ph, CFa). (M-2279, II, CII3, II, 4.(Me)2N-Ph, Hr), (M-2280, II, GHs, H, 4-(Mo)2N.Ph, GII：〇. (M-2281, II, CII3, II, 4-OII.Ph, H), (M-2282, II, CHa, II, d-OH-Ph, Cl), (M-2283, II, CHa, H, 4-OH-Ph, F), (M-2284, II, Clin, II, d-OH-Ph, CF3), (M-2285, II, CHa. H. 4-OH.Ph, Br), (M-2286, II, CHa, H, 4.〇H-Ph, CHa), (M-2287, II, CHa, II. 3.4- di.F-Ph, Η), (M-2288, H, CM,% II, 3,/1.di-F-Ph, Cl), (M-2289, II, CHs, H, 3.4- di-F.Ph, F), (M-2290, H, CHa, II, 3,4-di.F-Ph, CFn), (M-2291, H, CII3, H, 3.4- di-F.Ph, Br), (M-2292, II, CHa, H, 3,4.di.F-Ph, C1I3), (M-2293, II, CII3, II. 4-COOH.Ph, II), (M-2294, M, CHa, !I, ^l-COOII-Ph, Cl), (M-2295. IK CAL·, II, 4-COOII.Ph, F), (M-2296, II, CIIm, II, d-COOIMMi, CKa), (Μ-22Π7, H. Cllx H, 4-COOH-Ph, Br), (M-2298, II, CIIm, II, d.COOli.Ph, CHn), (M-2299, H, Clin, H, Bn. Η), (M-2300, H, CHa, H, Bn, Cl), (Μ-2；Η)1, II, CAhf H, Bn, F), (M-2302, II, 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) 裝---- 11111 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明（ OH.% H, Bn, CFa), (M-2303, H, CMa, H, Bn, Br), (M.2；K)4, H, CHa, II, Bn, CII：0. (M-2.mr), H，CHs，H, 4-F-Bn, Π), (M430G, 11，Clh，H, 4-lM3n, Cl), (M-2307. 11, CHs. H, 4-F-Bn, F), (M-2308, H, Clin, II, 4-P-Bn, CF；〇, (M-2309, H, CAU, H. 4-F-Bn. Br), (M-2310, H, CHs, H, 4-F.Bn, Clla), (M-2311, H, CHa, H, 2-Py, II), II, CII.% II, 2-Py, (Μ-2；ΜΜ, II, CIIm, II, 2-Py, l·1), (M-2；U I, II, H, 2-Py, CF3), (M-2315, H, CHa, II, 2-Py, Br), (M-2316, H, CH3, H, 2-Py, CH3), ίΜ-2317, H, CII3, H, 3-Py, Μ), (Μ.2；Π8, II, CHa, II, 3-Py, 〇D, (M-2319, Π, CHa. H, 3-Py, F), (M-2320, H, CHa, H, 3-Py, CK；〇, (M-2321, H, CII3, H, 3-Py, Rr), (M-2322, II, CH.3, H, 3-Py, CII3), (M-2323, II, CII3, H, 4-Py, Η), (M-2324, H, CH3. H· 4-Py, α), (M-2325, H, Clh, H,心f)y, K), (M-232G，11, Clla, 11，4-Py，CF3)， (M-2327, II, CII3, H, 4-Py, Br), (M-2328, II, CUa, II, 4-Py, CHs), (M-2329, H, CH.3, II, 2-Th, II), (M-2330, II, Clin, II, 2-Th, Cl), (M-2331, H, CHa, H, 2-Th, F), (M-2332, H，CH3, II, 2-Th, CUW, (Μ·23;ΚΪ, H, CH·% H, 2-Th，Br)，（M-2334, II， CH3, II, 2-Th, CH3), (M-2335, II, CHs, II, 3-Th, Η), (M-2336, H, CHs, II, 3-Th. Cl)，（Μ·2337, H, CHs, H, 3-Th，l·》，（Μ·2⑽8, U, Clh，H, 3-Th，CF3)，（M-2339, H, Clh，Π, .Vrh, I3r)，（M-2340, H，CU:i，11, ;]，rh，Cl卜)，H，Clb, Π, 吡唑-2·碁，Η), (Μ-2·Ή2, Π, Clh, II，吡唑-2·基，Cl), (M-2343, 11，Clh, H， 吡唑-2-基，F)，（M-2344, H，Clh, II,吡唑-2-基，CF3)· (M-2345, H，CU3. H, 吡唑-2-基，Br)，（M-234G, H, (〕lh，H,吡唑-2-基，CH3)，（Μ·2347, Π，CH3, H·吡唑-3_基，II)，（M-2348, 11，H,吡唑-3_基，（〕1)，（Μ·2349, H，CII3, 吡唑-3·基，F), (Μ:23Γ)0,丨【，Clh, 11，吡唑-3-基，CPa), (M-2351, Π, Glh， H.吡唑-3·基，Br), (M-2352, H，（】lh，11，吡唑-3-基，Clh)，（Μ·23Γ)3, 11， CAU, II, 0¾ -2-¾ , H), (M.2354, II, Clin, II, -2-¾^ Cl). (Μ-2；?Γ)Γ>. Π, C1I·% H,嘧啶-2·基，F)，（Μ·23 ㈣，II, II，嘧啶-2-基，Ch), (Μ· 2·%7· Η, CIK Η，嘧啶 _2-基，Βι〇,（Μ·2:3Γ)8, II，σΐΙ.Μ，Η,嘧啶-2-基， (Μ-23·Γ)9, Η, Clh, Η,嘧啶 _4-基，丨1)，（M-2;KUU1, CHa, 1ί，嘧啶-4-基， 124 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公釐） -裝--------訂----- (請先閱讀背面之注意事項再填寫本頁) A7 1284639 _____B7____ 五、發明說明（W)
Cl)，（Μ·2361, H，CH3, II,嘧啶-4-基，F)，（Μ·2;362, H, CH·% Η,嘧啶-4-基 ，CFs), (M-2363, H, CIIs, H,嘧啶-4 -基，Br), (Μ·2:}(Μ，H，CH3, II， 嘧啶-4-基，CH3), (Μ-23(;Γ), H, (m·% H,嘧啶-5-基，II), (M-23GG，11，Clh, H· 1嚼啶-5-基，Cl)，（M-2367,丨I,(〕丨K H,嘧啶-5-基，F), (M-2368, H， Clh，II,嘧陡-5-基，（】F·”），（Μ-2Μ(ί;>, II, (:IU II,喃 D定-5-基，Hr), (M-237U, H，CH.3, H,嘧啶-5-基，.（〕H3)，（M.2371, il, CH3, 11，HOOCCil2C：H2CH2, 11), (M-2372, Π, CII3, H, IIOOCCH2CII2CII2, Cl), (M-237：}, II, CIL·, II, HOOCCII2CH2CH2, F), (M-2374, II, CII3, H, HOOCCH2CH2CH2, CF3), (M-2375, H, CH3, II, HOOCCH2CH2CH2, Br), (M-2376, H, GHn, H, HOOCCII2CH2CH2, CH3), (M-2377, H, CH,3, II, HOOCCII2Cll2CIl2Cll2,U), (M-2378, 11, Clla, II, HOOCCII2CH2CH2CH2, Cl), (Μ-237», II, OH.% H, UOOCCII2CII2CII2CII2, F). (M-2380, H, CII3, H, HOOCCII2CH2CII2CII2, CFa), (M-2381, M, CII3. II, HOOCCH2CH2CH2CH2, Br), (M-2382, II, CHn, II, HOOCCH2CH2CII2CH2, CM；〇. (Μ·2383, H, CH3, H，（Me)2NCOCH2CIhCH2CIl2, Η), (Μ·2384, H, CII3, H, (Me)2NCOCH2CH2CII2CH2, Cl), (M-2385, II, Clla, H, (Me)2NCOCH2CM2CII2CH2, F), (M-238G, II, CUm, H, (M〇hNCOClhC\l〇C\UClU, CF：3>, (M-2387, H, CHs, H, (Me)2NC()CII2Cll2CIl2CH2, Hr), (M-2388. II, CII3, II, (Me)2NCOCH2CH2CH2CH2, CHa), (M.2385), II, Ciln, H, (Me)2NCOCH2CH2CH2CH2CH2, II), (M-2390, II, CM.% II, (Me)2NCOCH2CH2CH2CII2CH2, Cl), (M-2；U)1, H, CHn, M, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-2392, II, Clin, II, (Me)2NCOCH2CH2CH2CH2CH2, CKm), (M-2393, II, CIIm, H, (Me)2NCOCH2CH2CH2Cll2CH2, Hr), (Μ-2：3ί)4, II, Ciln, H, (Me)2NCOCIi2CH2CH2CIl2CH2, 0!!：〇, II, CIIm, H, M0OCU2, II), (M- 2396; H, CHa, H, MeOCIb, Cl), (M-2：H)7, ii, CHa, H, M0OCH2, F), (M-23D8. H. CH3. H, MeOClI2, CFa), (Μ-2：]ί)ί), II, Clla, II, Mo()CIl2, I3r), (M-2400, II. Oils. H, 125 表紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ill·——------•裝----- (請先閱讀背面之注音？事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 _B7 _ 五、發明說明（、W)
MeOCH2, CH.3), (M-2401, H, CIIm, II, KtOCHa, H), (M-2402, II, Clin, H, KtOClh, Cl), (M-2403, H, CHa, II, EtOCIh, (M-2404, H, CHa, Η, ΕΚ)ΟΗ2< CF：〇. (M-2405, H, CII.3, H, EtOClh, Br), (M-2406, II, CIIm, II, KtOClh, Clla), (M-2407, U, CHg. H, EtOCH2CH2, Η), (M-2408, Π, CII3, Η, Εί〇αΐΙ2〇Η2, Cl), (M-2409, H, CII3, H, Kt(JCIhCil2, F), (M-2410, II, CII.m, II, Kl()(：|CIV), (M-2III, II, CH.3, H, EtOCH2CH2, Br), (M-2412, H, GHn, H, EtOCH2CH2, CHa), (M-2413, 11, CH3, H, M0OCH2CH2OCII2CU2, II), (M-2414, II, CHa, II, MeOCH2CH2〇CH2CH2, Cl), (Μ-241Γ), II, CHa, M, M0OCH2CH2OCH2CII2. F). (Μ-241Γ3, H, CH,3, H, MeOCH2Cll2〇CII2CIl2, CFn), (M-2417, II, Clh. il MeOCIi2CH2〇CH2CH2, Br), (M-241H, H, OHm, il, MeOCU^ClhOClhClh. Cll：〇, (M-2419, II, CH.3, H, MeOCH2CII2, Η), (M-2420, II, CHa, H, MeOCH2CH2, Cl). (M-2421, H，CHs, H, MeOCihCih, l〇, (Μ·5Μ22, H, Clh，II, MeOCIhCIh，CF3)’ (M-2423, II，CH·% H, MeOClhCIh, Br), (Μ·2424, H, Clh, H, MeOCIhClh, Clh)， (M-2425, H, CH3, H, HOCH2, II), (M.242G, H, CHn, H, HOCH2, Cl), (M-2427, H, CH3, H, HOCH2, F), (M-2428, II, CII,% II, liOCIh, CF;〇, (M-2429, II, CHa, IL HOCH2, Br), (M-2430, H, CII3, Π, IIOCII2, Clin), (M-2431, H, CHn, II. IIOCII2CII2, II), (M-2432, II, CII.% H, MOCII2CII2, Cl), (M-2433, II, CII3. II, HOCH2CH2, F), (M-2434, H, CII3, H, IIOCH2CII2, CF;〇, (M-2435, H, CH3. H. HOCH2GH2, Br), (M-2436, II, II, HOGH2CM2, CAL·), (M-2437, M, CII3, II, HOCH2CII2CH2, Η), (M-2438, II, C1I,% H, IIOCH2CH2CII2, Cl), (M-2439, H, CHn, H. HOCH2CH2CII2, F), (M-2440, II, (ΜΙπ, II, HOCII2CH2CH2, CF3), (M-2441, Π, CH3. H, MOCH2CH2CH2, Hr), (M-24^12, II, CMa, II, 11()0112〇112〇112, CII：〇, (M- 2443, Π, CHn, II，HOClhCihClhClh，Π)，（Μ·2^Η4, fl，CHa, Π, IIOCH2CH2CM2CII2, Cl), (M-2/145, II, Clin, II, ΙΙ()ΟΙΙ2(>1ΐ2(：Ιΐ2〇1ΐ2, P), (M-24 1(>, H. CH.3, H, HOCH2CH2CH2CH2, CFm), (M-2447, 11, Clin, 11, MOCH2CH2CH2CH2. Br), (M-2448, II, CHn, H, 1100112(1.liaClIaC^Ih, CII,〇, (M-2449, H, CHn, H, I裳---- (請先閱讀背面之注意事項再填寫本頁) 訂--- 1 2(； 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 1284639 經濟部智慧財產局員工消費合作社印製 A7 ___B7___ 五、發明說明（、/) HOCH2CH2CH2CH2CH2, Η), (Μ-2450, H, CII«, Μ, IIOCH2CH2CII2CH2CH2, Cl). (Μ-2451, Η, CH3, Η, HOCH2CH2Cn2CH2Clh, F), (Μ·2452, Η, CH3, Η， IIOCH2CH2CH2CH2CH2, CFa), (Μ-245；3, II, CHn, II, ΙΙΟΟΙΐ2〇Ιί2〇Η2〇Η2〇112, Br)，（Μ-2454, Η, CHa, Η, HOClhClhClhUlhClh，Clln)，（Μ-2455, Η, C1U· 11， IiOCH2CIl2〇CIl2CIl2, ΙΙ), ΙΙ, CIIm, ΙΙ, ΙΙ()ΟΙΙ2(31Ι2〇(ΜΙ2(：ΙΙ-, (Μ), (Μ- 2457, II, CHa, Η, HOCH2CH2OCII2CII2, F), (Μ-2458, Η, CHs, Η, HOCH2CH2OCH2CH2, CF.3), (Μ.2451), Μ, CAL·, 1!, MOCH2CH2OCH2CH2. Βγ), (Μ-2460, Η, CH3, II, IIOCIi2CH2〇CIl2nil2, (M-24G1, Μ, CII^, Η, (Μο)ιιΝ. Η)? (Μ-2462, Η, Clhf II, (Μο)2Ν, CI), (Μ-2Ί(ί3, II, ΟΙΙ,μ, Μ, (Μο)2Ν, F), (Μ-241Μ, Η, CH.3, Η, (Me)2N, CF.3), (Μ-2465, II, CMa, II, (Me)2N, I3r), (Μ-2466, Η, Cth, Η, (Me)2N, CHs), (Μ·2467, II, CH··〗，Η,哌啶-4 -基甲基，Η), (M-24G8, 11· αΐ:ι Η，哌啶-4-基甲基，CI), (Μ·24(;9, U, ah, Π，哌啶·4-基甲基 I, F)， (Μ-2470, II，CH3, Η,哌啶-4-基甲基，CR*〇, (Μ·2471, Η, Ctk Π, 哌啶-4·基甲基:，Br), (Μ·2472, Η, CHn, Π，哌啶-4-基甲基丨，CH3), (M-2473, H, Clh, Η, < 環己基甲基，丨丨)，（M-2474, II，Clh, Η, ，環己基甲基，Cl), (Μ·247Γ》，丨丨，Clh,丨丨，《環己基甲基· F)，（M-247G，11， CH3, Η,環己基甲基丨，CFn), (Μ·2477, H，Clh, Ilj環己基甲基，Br), (Μ·2478, H, CH3, Η,環己基甲基，0113)，（1^_247{)，11，（：；113，？，11，11)，（1^-2480, Η, CH.3, F, H, Cl), (M-2481, H, CHa, ΙΛ Η, P), (M-2482, H, CH3, F, II. CFs), (M-2483, H, CH3, F, H, Br), (M-2484, 1【，C〕n·% H, CHn), (M-2485, [I，CIU, F, F, H)，（Μ·2鐵 H, CHs，F: F, Cl), (M·別87, U· Clh， F. CFs), (M-2489, H, CH3, F, F, Br), (Μ.24ί)0, II, CII3, F, F, CII3), (M-2491, H. CH.3, F, Cl, Η), (M-2492, H, CHn, F, Cl, Cl), (M-2493, II, C\h, F, Cl, F), (M-2494, H. CII3, F, Cl, CF3), (M-2495, II, Clh} K, Cl, Hr), (Μ-249β, II, CAh, F, Cl. CII3), (M-2497, II, CH.3, F, CHa, II), (M-2/|f)H, Π, (MIm, K, Clla, Cl), (Μ.24ί)9. II, CH：^, F, CII3, F), (M-2500, H, CH.3, F, Clhu (Μ-2Γ)01, H, CAUt F, CHa, Br), (M-2502. 127 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ----1——'-----%裝---- (請先閱讀背面之注音？事項再填寫本頁) tr--------- 1284639 A7 ___ B7__ 五、發明說明（id) (請先閱讀背面之注意事項再填寫本頁) }I. CH3, F, CII.3, 011,3), (M.2503, II, CUa, K, lit, II), (Μ-2Γ304, II, CAh, F, FA, Cl). (M-2505, H, CH3, F, Et, F), (M-25(K5, H, CHm, K, Kt, CF：〇, (M-2507, II, CHa, F, Kt. Br), (M-2508, H, CH.3, F, Et, CII；〇, (Μ-2Γ)0ί), II, CH.% K, n-Pr, 11), (M-2510, H, CH.3, F, n-Pr, Cl), (M-2511, II, Clla, F, n-Pr, F), (M-2512, H, CII3, F, n-Pr, CF3). (M-2513, II, CII.3, F, n-Pr, Br), (Μ.25Η, II, CIIm, Kt n-Pr, C：ll；»), (Μ-2ΠΙΓ), IL F. c-Pr, Η), (M-2516, H, CH3, F, c-Pr, Cl), (M-2517, H, GH3, F, c-Pr, F), (M-2518, H, CII3, F, c-Pr, CF.3), (Μ-2Γ319, II, CAht F, c-Pr, Br), (M-2520, H, CII3, F, c-Pr. CH3), (M-2521, H, CII3, F, i-Pr, II), (M-2522, Π, CM.% F, i-Pr, Cl), (M-2523. IT. CH3, F, i-Pr, F), (M-2524, II, F, i-Pr, CF；〇, (M-2525, H, Clin, P, i-Pr, Hr). (M-2526, H, CH,3, F, i-Pr, CH,〇, (M-2527, II, 011.3, F, n-Bu, II), (M-2528, 11, CH3. F, n-Bu, Cl), (M-2529, II, CH3, F, n-Bu, P), (M-2530, H, CHa, F, n-Bu, CF3), (M-2531, H, CHa, F, n-Bu, Br), (M-2532, H, Clin, F, n-Bu, CII3), (M-2533, IL CH3, F, i-Βυ, H), (M-2534, H, CII3, F, i-Ηυ, Ci), (Μ-2Γ335, II, CII3, F, i-Bu, F), (M-2536, H, CH3, F, i-Bu, CF3), (M-2537, II, CHa, F, i-Bu, Br), (M-2538, H, CHa, F, i-Bu, CII3), (M-2539, II, CU3, F, «oc-Hu, U), (Μ-2Γ)40, II, CHa, F, sec-Bu, Cl), (M-2541, H, CH3, F, sec-Bu, F), (M-2542, Π, CHa, P, boc*Bu, CFa). U, 經濟部智慧財產局員工消費合作社印製 CH.3, F, sec-Bu, Br), (Μ-2Γ344, II, Cila, F, roc-Hu, CII：〇, (M-2545, II, Clla, F. n-Pen, Η), (M-2546, H, CH3, F, n-Pon, Cl), (M-2547, II, CII3, F, n-Pen. F), (M-2548. IL CII3, F, n-Pen, CFa), (M-2549, li, CHa, F, n-Pon, Br), (M-2550, II, CII3, F, n-Pen, CHs), (M-2551, H, CHa, F, c-Pen, II), (M-2552, H, CHa, F, c-Pen, Cl), (M-2553, H, CHs, F, c^Pen, F), (M-2554, H, CHa, F, c-Pen, CF3), (M-2555, H, CHs, F, c-Pen, Br), (M-2556, H, CHa, F, c-Pen, CHa), (M-2657, H, CH3, F, n-Hex, Η), (M-2558, H, CH3, F, n-Hex, Cl), (M-2559, H, CHa, F, n-Hex, F), (M-2560. H, CH.3, F, n-Hex, CFa), (M-2661, II, Clia, F, n-Hox, Br), (M-2562, IL Clin, F, 11-Hex, CH3), (M-2563, H, CH3, F, c-flox, II), (M-256/1, II, Clin, F, c-IIex, Cl), (M-2565, H, CHa, F, c-IIex, F), (M.25G6, II, Cll,% F, c-IIox, CF：〇, (M-2567, II. 128 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） A7 1284639 ___B7 _ 五、發明說明（^7) CII3, F, c-IIex, Br), (Μ-2Γ368, H, CIIm, F, c-IIox, CMn), (M-2569, ll CII：3, F, OH, Η). (M-2570, II, CII3, F, OH, Cl), (M-2G71, II, CII3, F, Oil, F), (M-2572, II, Clla, F? Oil, CF3), (M-2573, H, Clin, F, OH, Hr), (M-2574, II, CHa, F, Oil, CH；〇, (M-2575, H, CHs, F, EtO, Η), (M-2576, H, CM.% F, EtO, Cl), (M-2577, II, CII3, F, ElO, F), (M-2578, H, CU,% K, KtO, Cl·1;»), (M-257!), II, CAht ΙΛ KlO, Mr), (Μ.2Γ)80, H. CH.3, F, EtO, CH3), (M-2581, II, CMa, F, n-PrO, Η), (M-2582, II, CII3, F, n-PrO, Cl), (M-2583, H, CIIs, F, n-PrO, F), (M-258/1, U, Clin, F, n-PrO, CFa), (M-2585, H, CH.3, F, n-PrO, lir), (M.258G, II, CHn, F, n-PrO, CHn). (Μ-2Γ)87, H. CII3, F, PhO, Η), (M-2588, II, CHn, P, PhO, Cl), (M-2589, II, Clin, F, PhO, F), (M-2590, H, CHa, F, PhO, CFa), (Μ-25ί)1, II, CHa, F, PhO, Br), (M-2592, 11, CH3, F. PhO, CHa), (M-2593, H, CII3, F, BnO, Η), (M-2594, H, CII3, F, BnO, Cl). (M-2595, H, CHa, F, BnO, F), (M.2506, H, Clin, F, BnO, CFa), (M-2597, II, CHa, F, BnO, Br), (M-2598, H, CH3, F, HnO, CU：〇, (M-2599, H, CII3, F, PhCH2Cll2〇. Η). (M-2600, H, CHa, F, PhCIhCihO, Cl), (M-2601, H, CII3, F, PhCH2CH2〇, F). (M-2602, H, CII3, F, PhCH2CIl2〇, CFn), (M-2603, II, CII3, F, PhCH2CH2〇, Br), (M-2604, H, Gils, F, PhCH2CH2〇, CMn), (M.2(505, II, Clht F, CFnO, II), (M-2(H)G, H, CII3, F, CF.3O, Cl), (M-2607, II, CIIm, P, CFmO, F), (M>2(H)8, II, CIb, F, CFaO, CFa), (M-2609, H, CH3, F, CFsO, Br), (M-2610, II, CH3, F, CFaO, CII3), (M-2611. H. CII3, F, Ph, Η), (M-2612, H, CHn, F, Ph, Cl), (M-2613, II, CII3, F, Ph, F), (M-2614, II, CH.3, F, Ph, CFs), (Μ.2(5ΙΓ), II, CHa, K, Ph, Br), (M-2616, H, CUa. F. Ph, CII3), (M-2617, H, CH3, F, 4-F.ph, Μ), (M-2618, II, CH3, F, 4-F-Ph, Cl), (M-2619, H, CH3, F, 4-F-Ph, F), (Μ-2(520, M, CIJ3, K, d-F-Ph, CF3), (M-2621, II, CH3, F, 4-F-Ph, Br), (M-2622, II, Clla, P, d-F-Ph, Clin), (M-2623, H, CII3, F, 4-CF.3-Ph, II), (M-2624, II, CHm, K, i-CFa-Ph, Cl), (Μ·2(52Γ), II, CIU, F, 4-CFa-Fh, F), (M-2626, H, CAh, F, CK：〇, (M-2G27, II, Clia, F, 4-CFn-rh. Hr). (M-2628, II, CII3, F, 4-CF3-Ph, CIIm), (Μ.2(ί2ί), 11, Clla, F, 4.(Mo)2N-Fh, H), 12i) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ill·——·-----%裝 (請先閱讀背面之注意事項再填寫本頁) 訂· — 經濟部智慧財產局員工消費合作社印製 A7 1284639 ___B7_____ 五、發明說明（id) ίΜ-2630, H, CH,3, F, 4.(Me)2N-Ph, 01), (M-2G：n, II, CM,% F, 4-(Mo)2N-Ph< F). (M-2G32, II, CAL·, F, 4-(Me)2N.[Mi, CP；〇, (M.2(；；5；l II, Clhu F, 4-(Mo)2N-Ph, Ur), (M-2G34, II, CII3, F, 4-(Me)2N-Ph, CH：〇, (M.2(；；}5, II, CAht F, 4-OH.Ph, H), (M-2636, H, CH.3, F, 4-OH.Ph, Cl), (Μ-2(537, H, CII3, F, 4-011-Ph, F), (M-2638. H. CU.i, F, ά^ΟΗΛΊι, CF：〇t II, CHm, l·1, l-OIMMi, Hr), (Μ.2Π10, II, ('H i, F, 4-OH-Ph, CH3), (M-2641, H, CHa, F, 3,4.di-F.Ph, Η), (M-2642, II, CH3, F, 3.4- cli-F-Ph, Cl), (M-2643, II, Cila, K, ；{,4-(ii.K.Ph, l〇, (M-2644, II, CHa, F, 3.4- iJi-F.Ph, CF3), (M-2645, H, Clla, l·1, 3,4-di-F.tMi, Br), (M.2G4G. H, CAL·, F. 3.4.(li-F-Ph, CH3), (M-2647, II, CIIaf F, 4.〇()()ΙΙ-ΡΗ, II), (M-2648, H, CH3, F, 4-COOIi-Fh, Cl), (M-2649, H, Clh, K, 4-COOH-Fh, F), (M-2G50, II, Cila, F, 4-COOH-Ph, CF3), (M-2651, H, CHa, K, 4-00011.Ph, Br), (M-2652, H, CHn, F, 4-COOH-Ph, CIIs), (M-2653, II, CHa, P, Bn, II), (M-2654, H, Oils, F, Bn, Cl), (M-2655, H, CH3, F, Bn, F1), (M-2G5(5, II, Clin, K, Rn, CFa), (M-2657, H, CII3, F, Bn, Br), (M-2658, II, CII3, F, Bn, GIIr〇, (M-2659, II, Clla, F, 4-F.Bn, II), (M-2660. H，Clh，F, 4-F-Bn，Cl), (M-2GG1, II, Clh，l·' F), (M-2GG2, Π, Clh, R 4-F-Bn, CFs), (M-2663, H, Clht F, d-F-Bn, Br), (M-26G4, M, CHn, F, 4-F-Bn. CH3), (M-2665, H, CII3, F, 2-Py, II), (M.2G06, 11, Clla, F, 2-Py, Cl), (M-2GG7, II, CH.3? F, 2-Py, F), (M-2668, II, CH3, F, 2-Py, CPa), (M-2G69, H, CFI3, F, 2-Py, Br), (M-2670, H, CH.3, F, 2-Py, CUa), (M-2(571, II, CUa, F, 3-Py, II), (M-2672, II, CHa, F, 3-Py, Cl), (M-2673, H, CHn, F, H-Py，(Μ-267Ί, II, CHa, F, 3-Py, CFs), (M-2675, H, CH3, F, 3-Py, Br), (M-207G, II, CII3, F, 3-Py, Clin), (M-2677, II, CII3, F, 4-Py, Η), (M-2678, H, CHa, F, 4-Py, Cl), (M-2679, H, CHa, F, 4-Py, F), (M-2680, H, CH3, F, 4-Py, CF3), (Μ·2681, H, CH3, F, 4-Py, Br), (M-2682, H, CH3, F, 4-Py, CH3), (M-2683, H, CH3, F, 2-Th, II), (M-2684, II, CHa, F, 2-Th, Cl), (M-2685, H, CH3, F, 2-Th, F), (M-2686, II, CH.% F, 2-Th, CFa), (M-2687. IL CII^. F. 2-Th, Br), (M-2688, H, CII3, F, 2-Th, CH；〇, (M-2689, II, CII3, F, 3-Th, Η), (M- 130 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) t--------IT--------- 經濟部智慧財產局員工消費合作社印製 A7 1284639 __B7____ 五、發明說明（1巧） 2690. II, CH.3, F, 3-Th, Cl), (M.2(5i)l, II, Clin, F, 3-Tht F), (Μ-20ί)2. H. CHn. F. 3-Th, CFs), (M-2693, II, Clhf F, ：3-Th, Hr), (M-2G94, II, 〇Π3, F, 3-Th. CII；〇, (請先閱讀背面之注意事項再填寫本頁) (Μ·2695, H, CH3, F,吡唑-2-基，H), (M-2(Um，li,⑶3, F,吡唑-2-基，Cl)· (Μ·2697, H，CH3, F，吡唑-2-基，K), (M-2G98, H，CH·% F，吡唑-2-基，CF:〇, (M-2Gi扣，11, CihU?,吡唑-2·基，Br)· (Μ·27()()，丨丨，（:丨丨”，ΙΛ 吡唑-2·基，（】丨l:i)， (Μ·2701, H, CH3, F,吡唑-3-基，丨丨)，（Μ·27ί)2, ti，CH3, F，吡唑-3-基，C1). (M-2703, H, CH3, F,吡唑-3-基，卜、)，（Μ·27(Μ, I丨，（〕丨h，F，吡唑-3·基，Cl〜)， ίΜ·270Γ), 11, Clh, F,吡唑-3-基，Br), (Μ·270ί5,丨丨，Γ]丨n，忆吡唑-3-基，（1Π:Λ· (M-2707, H, Clh, F，嘧啶-2-基，丨1)，（Μ-2708, II，F，嘧啶-2-基，Γ1)， (M-2709, H, CH3, F,嘧啶-2-基，F), (Μ-2710, 11, CH3, F,嘧啶-2-基， CF3)，（Μ·2711, H，CH3, F,嘧啶-2-基，Br), (Μ·2712, H，CH3, F， 經濟部智慧財產局員工消費合作社印製 嘧啶-2-基丨，CH3), (Μ·2713, II, Clh, IV 嘧啶-4-基，H)，（Μ·271( II，CIb， F,嘧啶-4-基，Cl), (Μ·2715, Η· CHa, F,嘧啶-4-基，F)，（M-2716, H，CH3, F，嘧啶·4_基，CF3), (Μ·2717, H, CHa, F,嘧啶-4-基，Br)，（M-2718, H， CH3, F，嘧啶-4·基，CH3), (Μ·2719, H, CH3, F,嘧啶-5-基，H)，（M-2720, H, Clh, F,嘧陡-5 -基，Cl), (Μ·2721, H, Clh，F,嘧陡一 5 -基，F1)，（M-2722, H，CH3, F,嘧啶-5-基，CF3), (Μ·2723,丨丨，Clh，F，嘧啶-5·基:，Br>，（M· 2724, H, CH3, F,嘧啶-5-基，Clh)，（Μ-272Γ)，H, Cll·% F，IIOOCCH2CII2CH2, Η), (M-2726, H, CH3, F, HOOCCII2CH2CH2, Cl), (M-2727, H, CH3, F, HOOCCH2CH2CH2, F), (M-2728, H, CHa, F, IIOOCCH2CH2CH2, CF3). (M-2729, H, CH3, F, HOOCCH2CH2CH2, Br), (M-2730, H, CII3, F, HOOCCH2CH2CH2. CH3), (M-2731, H, CH.3, F, HOOCCII2CII2CII2CII2, Μ), (M-2732, H, CH3, F, HOOCCH2CH2CH2CH2, Cl), (M-2733, 11, CAU Ff HOOGCM2CH2CH2CH2, F), (M-2734, H, CH3, F, HOOCCii2CIl2CI[2Cll2, (M-2735, II, CII3, F, HOOCCH2CU2CII2CH2, Br), (Μ-27：Κ5, II, C\ht l·1, ΙΙ()()(Χ>Η2〇Ιΐ2〇Ιΐ2〇Π2. CH：〇, (M-2737, II, CHa, F, (Μθ)2ΝΟ()ΟΙΐ2〇Ιΐ2〇Η2〇Ιΐ2, II), (M-2738, II, CII3. F. ΚΠ 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 五、發明說明（iw) iMe)2NCOCH2CH2CH2CH2, Cl), (M-2739, H, CHn, F, (請先閱讀背面之注音？事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 iMe)2NCOCII2CIl2CH2CIl2, F), (M-27d(), II, Cll：i, P, (Mo)2NCOCll2(MIiiCH2CH2. CFa), (M-2741, II, Clh, F, (Me)2NC()CII2CIl2Cll2CIl2, Hr), (M-2742, II, F, (Me)2NCOCH2CH2CH2CH2, CHn), (M-2743, II, CH3, F, (Me)2NCOCU2CH2(；II2CIl2Cll2, II), (Μ-27Ί/1, II, (ΊΙ.μ, l·1. (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-2745, II, CII3, F, (Me)2NCOCU2CIl2CH2Cn2CIi2, F), (M-274(5, II, Cila, F, (Me)2NCOCH2CH2CH2CH2CIl2, CKn), (M-27^17, U, CMm, F, (Me)2NCOCH2CH2CH2CH2CH2, Br), (Μ·2748, H，F, (Me)2NCOCH2CH2CH2CIl2Cli2, CiI；〇, (M-2745), 11, CILa, F, MoOClh, Η), (M-2750, H, CHa, F, MeOCH2, Cl), (M-2751, II, CII3, F, MeOCH2, F), (M-2752, II, CHa, F, MeOCH2, CFa), (M-2763, H, CHa, F, MeOCH2, Br), (M-2764, H, CH3, F, MeOCH2, CHa), (M-2755, H, CHa, F, EtOCH2, Η), (M-2766, H, CHs, F, EtOCH2, Cl), (M-2757, H, CH3, F, EtOCH2, F), (M-2768, H, CHs, F, EtOCH2, CF3), (M-2759, II, CHa, F, EtOCH2, Br), (M-2760, II, CII3, F, EtOCH2, CHa), (M-2761, H, CH3, F, EtOCH2CH2, Η), (Μ·2762, CH·% F, EtOCIhCHa, Cl)，（M-27G3, II， CH3? F, EtOCH2CH2, F), (M-2764, It, Cila, F, EtOCIhCIh, CFa), (M-2765, II. CH.3, F，EtOCH2CH2, Br), (M-27GG, II, CHa, F, KWClhCH2, CH3), (M-2767, H, CII.3, F, MeOCIl2CH2〇CH2GH2, Η), (M-2768, II, Clla, F, MeOCIhCIhOClhCHs, Cl), (M-2769, H, CH3, F, MeOCH2CII2OCH2CH2, P), (M-2770, H, CII3, F, MeOCH2CH2〇CH2CH2, CF3), (M-2771, H, CII3, F, M0OCH2CH2OCH2CH2. Br), (M-2772, H，CH3, F, MeOCH2CIh〇(】IhClI2, Clh)，（M-2773, H, CII3, F， MeOCH2CH2, Η), (M-2774, II, CUm, F, Μο()Οίί2〇!Ι2, Cl)4 (M-2775. II, CII^ F. MeOCH2CIl2, F), (M-2776, II, Clin, MoOCII2CIl2, CKn), (M-2777, IU Clla, F,
MeOCH2CH2, Br), (M-2778, H, CHm, M0OCII2CIl2t (Min), (M-277f). II. Clh, F. IIOCII2, Η), (M-2780, II, CH3, F, HOCIh, Cl), (M-2781, II, CH3, F, IIOCH2, F), 132 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） A7 1284639 ___B7 _ 五、發明說明（〜） (M-2782, H, CH.3, F, IIOCII2, CF.〇, (M-278；}, II, Clin, F, IIOCH2, Hr), (M.2784. H. Gils, F, HOCH2, CH3), (M-2785, H, CAhf P, HOCH2CM2, Η), (M-2786, H, CII3, F, HOCH2CH2, Cl), (M-2787, H, CHa, K, IIOCH2CII2, F), (M-2788, H, CII3, F, HOCH2CH2, CFa), (M-2789, H, CII3, F, HOCH2CH2, Br), (M-2790, H, CH3, F, HOCII2CH2, CH3), (M-2791, H, Clia, K, IlOiMhClhClh, 11), (M-27!)2, II, C：II；i, K, HOCH2CH2CH2, Cl), (M-2793, II，C1I·% F, HOCH2CH2CH2, F), (M-2794, II，CHi F, HOCH2CH2CII2, CF；〇, (M-27i)5, J[, CI1,, F, II〇CiI2CH2CIl2, Hr), (M-27S)(5, H. CII3, F, HOCH2CH2CH2, CH：〇, (Μ-27Π7, 11, C\h} F, HOClhCHiCIhCIh. II). (M-2798, H, CII3, F, HOCII2CH2CII2CH2, Cl), (M-2799, II, CHa, F, HOCH2CH2CH2CH2, F), (M-2800, H, Clin, F, IIOCH2CH2CH2CH2, CF3), (M-2801, H, CH3, F, HOCH2CH2CH2CM2, Br), (M-2802, II, CII3, F, HOCU2CH2CII2CH2, Gils), (M-2803, II, Clla, F, UOCmClUCAUClhCHo., M), (M-28(M, II, CHa, F, Η〇αΐΐ2〇Ιΐ2〇Μ2(Μί2〇ΙΙ2, Cl), (Μ-280Γ3, II, Clla, F, HOCH2CH2CH2CH2CH2, F), (M-2806, H, CH3, F, HOCH2CH2CH2CH2CH2, CF3)， (M-2807, H, CHa, F, HOCH2CH2CH2CH2CH2, Br), (M-2808, H, CHa, F, HOCH2CH2CH2CH2CH2, CHs), (M-2809, H, CHa, F, HOCH2CH2〇CH2CH2, H), (M-2810, H, CHa, F, HOCH2CH2OCH2CII2, Cl), (M-2811, H, CHa, F, IIOCH2CH2OCH2CH2, F), (M-2812, II, CHa, F, HOCH2CH2OCH2CH2. CFa), (M-2813, H, CHa, F, HOCH2CH2OCII2CH2, Br), (M-2814, H, CH3, F, HOCH2CH2OCH2CH2, CHa), (M-2815, H, CHa, F, (Me)2N, Η), (M-2816, H, CH3, F, (Me)2N, Cl), (M-2817, H, CH3, F, (Mo)2N, F), (M-2818, H, CH3, F, (Me)2N, CFs), (M-2819, H, CHa, F, (Mo)2N, Br), (M-2820, H, CH3, F, (Me)2N, CH3), (M-2821，H，CHn, F,哌啶-4_ 基甲基 I，〖〖)，（M.2822, H, Clh, F\ 哌啶-4 •基甲基，Cl)，（M-2823, H，Clh, IV 哌啶-4 -基甲基，F)，（M-2824, H， CH3, F,哌啶-4 ·基甲基，CF：〇· (Μ·282Γ), H，CHn, F,哌啶-4 -基甲基， Br), (Μ·2826, H, CH3, F,哌啶-4-基甲基，CH3), (Μ·2827, H，Clh，F， 13:} 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公1 ) ----r---.-----裝---I (請先閱讀背面之注意事項再填寫本頁) 訂---------聲· 經濟部智慧財產局員工消費合作社印製 1284639 經濟部智慧財產局員工消費合作社印製 A7 ____B7___ _ 五、發明說明。一） 環己基甲基丨，Η), (Μ·2828, II, (:Ih, P,環己基甲基，Cl)· (Μ·2829· Η, ch：3, b m ψ m , (m-2H3〇, h, cum, b m ψ m > cf；〇, (M-2831, H, Cih, F，環己基甲基，Br)，（Μ·28:32, U, CHa,P， 環己基甲基，CH3), (M-2833, II，Clh，Cl，II，H)，（M-2834, H，CH3, Cl，II， Cl)? (M-2835, II, Cihf Cl, II, F), (M-28；H5, II, CIIm, C\, II, (ίΚ；〇, (Μ-28；Π, II, Ul·», Cl, H, Br), (M-2838, H, CHs, Cl, II, CIIs), (M-2839, II, GH;i, Cl, F, il), (M-2840, If, CH3, Cl, F, Cl), (M-28/11, H, CI!^ 01, ΙΛ F), (M-2842, Π, Clin, Cl. F. CF；〇. (M-2843, M, CII3, Cl, F, Br), (M-284^ H, CII,% Cl, F, CHa), (M-2845, Π. CH3, Cl. CL Η), (M-2846, H, CII3, Ci, Cl, Cl), (M-2847, II, CHa, Cl, Cl, F), (M-2848, H, CHa, Cl Cl, CF3), (M-2849, H, CLIa, Cl, Cl, Br), (M-2850, U, CH3, Cl, Cl, Clla), (M-2851, H, CH3, Cl, CHa, H), (M-2852, H, Clla, Cl, CII3, Cl), (M-2853, H, CII3, Cl. CH.3, F), (M-2854, H, CII3, Cl, CHm, CFn), (Μ-28β5, H, CII.% Cl, Clla, Br), (M-2856, II, CFb, Cl, CII3, CII3), (M-2857, H, CHn, Cl, Et, Η), (M-2858, H, CIL·, CL Et, Cl), (M-2859, H, CHa, Cl, Et, F), (M-2860, H, CHa, Cl, Et, CF3), (M-2861, H, CHa, Cl, Et, Br), (M-2862, H, CHa, Cl, Et, CII3), (M-2863, H, CH3, Cl, n-Pr, II), (M-2864, H, CII3, Cl, n-Pr, Cl), (M-2865, II, CHa, Cl, n-Pr, F), (M-28(；6. H. CH3, Cl, n-Pr, CF3), (M-2867, II，Clh，Cl, n-l)r, Br), (M.28G8, H，C1U Cl, n-Pr， CII3), (M-2869, II, CII3, Cl, c>Pr, Η), (M-2870, H, CM,% 01, c-Pr, Cl), (M-2871. II, CH.3, Cl, c-Pr, F), (M-2872, H, Clin, Cl, c-Pr, CFn), (M-2873, H, CII3, Cl, c-Pr. Br), (M-2874, H, CH3, Cl, c-Pr, Clin), (M-2875, II, CII.3, Cl, i-Pr, Η), (M-2876. H. CHs, Cl, i-Pr, Cl), (M-2877, H, CII3, Cl, i-lVr, F), (M-2878, H, CII3, Cl, i-Pr, CF3), (M-2879, H, CH3, Cl, i-Pr, Br), (M-2880, H, CII3, Cl, i-Pr, CII3), (M-2881, H. CII3, Cl, n-Bu, Η), (M-2882, II, CII；$, Cl, n-Bu, Cl), (M-2883, II, CH3. Cl, n-Bu. F)? (M.2884, II, CII3, Cl, n-Βυ, CK：〇, (Μ-288Γ), lif CH,n, Cl, n-lki. Hr). (M-288(5, H CH.3, Cl, n-Βυ, CII3), (M-2887, II, CIIm, Cl, i-Bu, II), (M-2888, II, CHa. Cl, i-Bu. Cl). (Μ·2889, H, CH3, Cl, i-Bu, F), (Μ·28ί)()，CHb, Cl, i-Bu, CFV), (Μ·28ί)1, II， 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 裝--------訂--------- φ (請先閱讀背面之注意事項再填寫本頁) 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明) CH.3, Cl, i-Bu, Br), (M-2892, H, CHa, Cl, i-Ηυ, CII；〇, (M-28i)3, II. C\h, Cl. soc-Bu. Η), (M-2894, II, CH3, Cl, soc-Hu, Cl), (Μ-28ί)5, II, CHa, Cl, sec-Bu, F). (M-2896, H, CH,3, Cl, sec-Bu, CFa), (M-2897, H, Cll.% Cl, «oc-Bu, Br), (M-2898, H. CH3? Cl, sec-Bu, CHs), (M-2899, 11, CHn, Cl, n-Pen, Η), (M-2900, H? CHs, CL n-Pen, Cl), (M-2901, II, (JHn, (Jl, n-Pon, l·1), (M-2!)()2, II, (ΊΙμ, (Ί, n-Pon, (ΜΛΟ, (M-2903, H, CH3, Cl, n-Pen, Br), (M-2904, H, CUn, Cl, n-P(3n, CII3), (Μ.290Γ), II, CH.3, Cl, c-Pen, II), (M-290G, H, CHa, Ci, oPon, Cl), (M-2907, II, CII3, Cl, c-Pen. F), (M-2908, H, CII3, Cl, c-Pen, CFn), (Μ.2ί)0ί), II, Clin, Cl c-Pen, Br). (M-2910, II, CII3, Cl, c-Pen, CH3), (M-2911, II, CHa, Cl, n-IIex, Η), (M-2912, H, CH3, Cl, n-Hex, Cl), (M-2913, H, CH3, Cl, n-Hox, F), (M-2914, H, CHa, Cl, n-Ilex, CF3), (M-2915, H, CH3, Cl, n-Hex, Br), (M-2916, II, Clin, Cl, n-Ilex, CII3), (M-2917, II, CII3, Cl, c-Hex, Η), (M-2918, H, CII.m, Cl, o-Mex, Cl), (M-2919, II, CII3, Cl, c-llox. F)? (M-2920, H, CII3, Cl, c-Hex, CFa), (M-2921, H, CH.m, Cl, c-Mox, Br), (M-2922, II. CH3, Cl, c-IIex, CH.3), (M-2923, II, Clin, Cl, Oil, Η), (M-2924, II, CHn, Cl, OH. Cl), (M-2925, H, CH3, Cl, OH, F), (M-2926, II, CMa, Cl, OH, CFa), (M-2927, H, CII3, Cl, OH, Br), (M-2928, II, Gila, Cl, Oil, CHn), (M-2929, H, Clla, Cl, KtO. H). (M-2930, H, CH3, Cl, EtO, Cl), (M.29；H, H, Clla, Cl, KtO, F), (M-2932, II, CII3, Cl, EtO, CF3), (M-2933, H, CHn, Cl, EiO, Hr), (M-2934, H, CII3, CK EtO, CH^), (M-2935, II, CII3, Cl, n-PrO, H), (M-293(；, II, CHn, Cl, n-PrO, Cl), (M-2937, H, CHa, Cl, n-PrO, F), (M-2938, II, Cl[3, Cl, n-PrO, CF；〇, (M-2939, H, CH3, Cl, n-PrO, Br), (M-2940, II, CII3, Cl, n-PrO, Cll,〇, (M-2941, H, CHa, Cl, PhO, H), (M-2942, II, CHs, Cl, PhO, Cl), (M-2i)43, II, CII.% Cl, PhO, F), (M-2944. II. CH3. Cl, PhO, CFe), (M-2945, II, CII3, Cl, PhO, Hr), (M-2S)4G, II, CHa, CK PhO, CH：〇, (M-2947, II, CHs, Cl, BnO, II), (Μ-2ί)^Ι8, II, Cila, Cl, HnO, Cl), (Μ-2ί)1ί), U, C\L·, Cl. BnO, F), (M-2960, II, CII3, Cl, HnO, ΟΙΛ·〇, (Μ-2ί)51, II, CII3, Cl. BnO. Br). (M-2952, H, CH3, Cl, BnO, CU.〇, (Μ.21)Γ)3, II, Clin, Cl, PhClhCIhO, Η), (M- 】:3Γ) 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） --J----.-----裝--------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 1 0 J 3 55 經 濟 部 智 慧 財 產 局 員 工 消 「社 丨：印 製 五、發明說明（1%) 2954, H, Clh, Cl, PhCH2CIl2〇, CI), (Μ-2ί)5Γ), II, CHm, Cl, PhCIhCIhO. F). (M-295G, II, Clh, Cl, PhCH2CII20, CK〇, (Μ-2ί)Γ)7, H, Clhf Cl, PhCIl2ClI2〇, Br), (M-2958, II, CII3, Cl, PhClhClhO, Cli：〇, (M^Df)!), ii, CHa, CL CI^O, Η), (M-2960, H, CHs, Cl, CFsO, Cl), (M.29(}1, H, CH,% Cl, CP3O, F), (M-2962, H, CII3, Cl, CF.A), CF：〇, il, CHa, Cl, (ΊΛμΟ, Hr), II, (ΊΙ,μ, (Ί, (ΊΛ«(), (ΊΙ,Ο, (M-2965, H, CH.3, Cl, Ph, Η), (M-2966, II, CHa, Cl, Ph, Cl), (Μ-29ϋ7, II, Clin, Cl, Ph, F)? (M-2968, H, Clh, Cl, Ph, GP；〇, (M-2i)Gl), II, CIIm, Cl, Ph, Br), (Μ-2ί)70. II, CAh, Cl, Ph, CH.〇, (M-2971, II, CIIm, Cl, II), (M-2972, II, CHm, Cl, 4-F-
Ph. Cl), (M-2973, H, CH3, Cl, 4-F-Ph, F), (M-2974, II, CHa, Cl, 4-F-Ph. CF：〇, (M-2975, H，CH3, Cl, 4-F-Ph, Br), (M-297G, H, (_】山，（几 4-F-l)h，C[h)，（M-2977, IL CII3, Cl, 4-CF3-Ph, H), (M-2978, II, Clin, Cl, 4-CKa-Ph, Cl), (M-2979, H, C\h, Cl, 4-CF.3-Fh, F), (M-2980, Π, CH；i, Cl, 4-CFa-Ph, CFm), (Μ-2ί)81, II, Clh, Cl. 4-CF：3-Ph, Br), (M-2982, M, CHn, Cl, 4-CK；]-Ph, CH；〇, (M-2983, II, CHn, Cl, 4-(Me)2N.Ph, Η), (M-2984, H, CII3, Cl, 4-(Mo)2N-Ph, Cl), (Μ-298Γ3, H, CII3, Cl, 4-(Me)2N-Ph, F), (M-2986, H, CAhh Cl, 4.(Mo)2N.i)h, CFa), (M-2987, II, CII3, Cl, 4-(Me)2N-Ph, Br), (M-2988, II, CIIm, Cl, ^.(Mo)2N-Ph> CII3), (M-2989. II. ClI：',. Cl. 4-011-Ph, Η), (M-2990, II, CIIm, Cl, 4-()lI-Ph, Cl), (M-2991, II, CHa, Cl, 4-OH-Ph, F), (M-2992, H, CII3, Cl, 4-01 l-Ph, CF；〇, (Μ-2ί)9；}, II, Clla, Cl, 4-OH-Ph. Br). (M-2994, H, CII3, Cl, 4-OII.Ph, CII；〇, (Μ-2ί)ί)5, II, CHa, Cl, 3,4-di-F-Ph, H), (M-2996, II, CHs, Cl, 3,4-di-F-Ph, Cl), (M-2997, II, Clla, Cl, 3,4-di.F-Ph, F). (M-2998, H, CH3, Cl, 3,4-di-F-Ph, CF；〇, (M.29i)f), II, Clhf Cl, S^-di-F-Ph, Br), (M-3000, H, CII3, Cl, 3,4-di-F.Fh, CIIr〇, (M-3001, II, Clin, Cl, 4.COOII-Ph, M), (M-3002, II, CH.3, Cl, 4-COOH-Ph, Cl), II, Clh} Cl, 4-COOII-rh. F), (M-3004, II, CAL·, Cl, 4-0(Χ)ΙΜΜι, CK：〇, (M-：U)05, II, CAh. Cl, 4-COOH-Ph, Hr), (M-3006, II, CII3, Cl, 4-COOII-iMi, CIIm), (M-；M)07, II, Oil,% Cl. Hn. II). (M-3008. H. CAU, Cl, Bn, Cl), (Μ-300ί), II, CH,% Cl, Bn, l〇, (M.：«)l(), H, CIL·, Cl. Bn. CF；〇, l：{(； 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） >裝--------訂--- (請先閱讀背面之注意事項再填寫本頁) # 1284639 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明（（V) (Μ-.30Π, II, CH.3, C), Bn, Br), (M-；)012, H, Cl, Bn, Clla), (M-301；l II, CHa. CL 4-F.Bn, II), (M-3014, H, Clh, Cl, 4-F-Bn, Cl), (M.；]〇15, II, Clla, Cl, 4-F-Bn, F). (M-3016, H, CH3, Cl, 4-F-Bn, Cl^), (M-3017, II, Gila, Cl, 4-F-Bn, Br), (M-3018, H, CHa, Cl, 4-F-Bn, CH3), (M-3019, II, CH3, Cl, 2-Py, Η), (M-3020, H, CH3, Cl, 2-Fy, Cl), (M-3021, II, CII；i, Cl, 2-Py, l·1), (M-；H)22, II, CIIm, (Ί, 2-Py, (ΜΛμ), (M-3023, H, CH.3, Cl, 2-Py, Br), (Μ-；]〇24, II, CM3, Cl, 2-Py, CH3), (M-3025, II, CHs, Cl, 3-Py, Η), (M-3026, H, Clin, Ci, Cl), (M-：H)27, II, CII3, Cl, 3-Py^ (M-3028, II, CH,3, Cl, 3-Py, CF,〇, (M-3029, Π, CHn, Cl, 3-Py, Rr), (M-3030, II. CH3? Cl, 3-Py, CH3), (M-3031, II, Clin, Cl, 4-Py, II), (M-3032, H, CHa, Cl 4-Py, Cl), (M-3033, H, CH.3, Cl, 4-Py, F), (M.3034, H, CII3, Cl, 4-Py, CFa), (M-3035, II. CHa, Cl, 4-Py, Br), (M-3036, Π, CHa, Cl, 4-Py, CH 0, (M-3037, II, CHa, Cl, 2-Th, II). (M-3038, H, CH.3, Cl, 2-Th, Cl), (M-30；M), II, CH.% Cl, 2-Th, P), (M-3040, II, CHs, Cl, 2-Th, CF3), (M-3041, II, Clia, Cl, 2-Th, Br), (M-3042, H, CH3, Cl, 2-Th, CH3), (M-3043, H, CII3, Cl, 3-Th, Η), (Μ-；Η)44, H, Clia, Cl, 3-Th, Cl), (M-3045. M, CH3, Cl, 3-Th, F), (M-3046, H, Clla, Cl, 3-Th, CF3), (M-3047, H, CII3, Cl, 3-Th, Br), (M“KM8, H, CH·% (儿.Vl’h, Clh)，（Μ·:Μ)4ί), H, CH·% Cl,吡唑-2-基 ί, Π), (Μ·305()，H, CH3, Cl,吡唑-2-基，Cl), (Μ·30(31，II，CUa, Cl,吡唑-2-基，F), (M-3052, H，CH3, Cl,吡唑-2-基，€：1〜)，（从-3()5:3，虬（^13,(：：1,吡唑-2-基， Br), (M-3054, H, CHa, Cl, [ft ^ -2-¾. CII；〇, (M-3055, II, CHa, Cl, ft ^ -3-基，H)，（M-305G，H, CH3, Cl,吡唑-3-基，Cl), (Μ·3057, 11, CH3, Cl, 壯唑-3·基，F), (M-3058, H，C!h,(凡吡唑-3-基，CF3), (Μ·3059, Η· CHs, Cl， 壯唑-3-基，Br), (M-3060, Η, σ丨h，Cl,吡唑-3-棊，Clh)，（M-30(U，H，CII3. Cl，嘧啶-2·基，H), (M-30G2, II, Clh, (〕1,嘧啶-2-基，Cl)，（M-30G3, H· CH3, Cl,嘧啶-2-基，F), (M-3(KH. II，（〕丨，：嘧啶-2-基，CFs)，（M-3(K;5, H. CH3, Cl,嘧啶-2-基，Br), (Μ·:30Γ，《, II，（〕lh, Γ儿嘧啶-2-基,Clh)， (M-3067; H，CH3, Cl,嘧啶-4-基 1, Η), (Μ·30(;8, 11，CU·% Cl，嘧啶-4-基， 1：J7 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ---i-----------------訂--I------^^^1 (請先閱讀背面之注意事項再填寫本頁) A7 1284639 ____B7___ 五、發明說明（1^ ) C1)，（Μ···9, H, CH.3, Cl,嘧啶-4-基，Π, (Μ·:3070, H，Clli 基· CF3)，（Μ·3071，H, CH:】，Cl, i:嘧啶-4'基,，1 ⑺，（M-3072, H’ C丨h，Cl， 嘧聢-4-基，CH3), (M-3073, 11，Clh，（〕丨，嘧啶-4-基，H)，（M-3074, H，CH3· Cl.嘧啶-5·基，C1)，（Μ_307Γ)，丨〖，Ciln, (31，喃啶-5-棊，F)，（M-307G，Η. CHri, Cl, ^ -5-¾ , Cl·1,Μ), (Μ-Μ077, II, ^\Ιλ, Cl, |l^ D® -5-¾ , Mr), 3078, Η, CH3, C1,】嘧啶-5-基，Clh), (Μ·3079, Η, CH3, C1, HOOCCH2CH2CH2, Η), (Μ-3080, II, Cll.n, Cl, IIOOCCII2CH2CH2, Cl), (M-3081, H, CII3, Cl, HOOCCH2CH2CII2, F), (M-3082, II, CHa, Cl, HOOCCH2CH2CII2. CI^). (M-3083, II, CHa, Cl, HOOCCII2CM2CII2, Hr), (M-3084, II, CHa, Cl HOOCCH2CH2CH2, CH3), (Μ-308Γ), H, Clh, Cl, HOOCCH2Cll2ClhCH2, 11)， (M-3086, H, CII3, Cl, IIOOCCII2CU2CII2CII2, Cl), (M-3087, II, CHa, Cl, HOOCCH2CH2CH2CII2, F), (M-3088, II, ΟΠ.3, Cl, HOOCCH2CM2CII2CII2, CFa), (M-3089, II, CII3, Cl, IIOOCCIl2CIl2CIi2CIl2, Hr), (M.3090, II, Clin, Cl, HOOCCH2CH2CH2CH2, CHa), (Μ-30ί)1, H, CH3, Cl, (Me)2NCOCH2CH2CH2CH2, Η)· (Μ·3092, H, CH3, Cl, (Μ(?)2Ν(〕〇αΐ2ΟΗ2αΐ2σΐ[2, Cl)，（Μ·3093, II，CII3, Cl， (Me)2NCOCH2CH2CH2CH2, F), (M-：]〇94, II, Clla, Cl, (Me)2NCOCH2CIl2CH2CH2, CFa), (M-3095, II, CII3, Cl, (Me)2NCOCH2CH2CH2CH2, Br), (M.309G, ii, CHa, Cl, (Me)2NCOCH2CH2CH2CH2, CH3), (M-3097, H, CHn, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-：3098, II, CUa, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Ci), (M-3099, H, CHm, Cl, (Me)2NCOCH2CH2CH2CIl2CU2, K), (M-iUOO, II, CII.% Cl, (Me)2NCOCIl2CH2CH2CH2CIl2, CF；〇, (Μ-ίΠΟΙ, II, Cl 1,% Cl, (Me)2NCOCH2CH2CH2CH2CII2, Br), (Μ*；Π()2, II, Clin, Cl, (Me)2NCOCH2CH2CH2CM2CIl2, CIIm), (Μ-ίΜΟ：}, II, Clin, Cl, M0OCII2, II), (M-3104, Hf CH.3, Cl, MeOCIh, Cl), (Μ.：ΠΟΓ), II, C|[;i, Cl, M0OCII2, F), (M-；310G. H. 138 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） (請先閱讀背面之注音2事項再填寫本頁) 裝--------訂— 鵡 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 _ B7 五、發明說明（Μ) CII.3, Cl, MeOCH2, CF3), (M-3107, 11, Clla, Cl, M0OCII2, Hr), (M-3108, H, C\h, Cl· MeOCH2, CH3), (M-3109, 11，（〕Πη, Cl, EtOCih，Η), (Μ·3110, II，CIK Cl, EtOCH2, Cl), (M-3111, H, Clhf Ci, KlX)CII2, P), (M.3112, H, CH3, Cl, EtOCIh. CF3), (M-3113, II, CHa, Cl, EtOCHa, Hr), (M.3M4, H, CHa, Cl, EtOCIh, CH3), (M-3115, H, Clh, Cl, ΕΙΟΟΙΙ2(ΜΙ2, II), (M-MIK；, II, CIIm, Cl, Kt()(：ll2CH2, IM), (M-3117, H, CH3, Cl, Et()CH2CH2, F), (M-3118, II，CII3, Cl, EtOCH2CII2, CF3), (M-3119, H, CH.3, Cl, EtOCH2Cll2, Hr), (M-；312(), H, CHa, Cl, EtOCIhCIh, CIl；〇. (M-3121, H, CHs, Cl, ΜθΟΟΗ2ΟΙΙ2〇ΟΙΙ2〇1Ι2, Η), (Μ-；Π22, II, CHn, Cl, MeOCIhCthOCthCIh, Cl), (M.：312；l, Π, CHm, Cl, MoOCIIaClhOCfhCII2, F). (M-3124, H, CH3, Cl, MeOCil2Cil2()(m2CH2, CP3), (Μ·312δ, H, CH3, Cl, MeOGll2CH2〇CH2CH2, Br), (Μ-ίΠ26, II, Clla, Cl, MoOClUCAhOClhCAh, CAU). (M-3127, II, CHs, Cl, MeOCH2CIl2, II), (M-3128, II, CAL·. Cl, ΜοΟΟΗ2ΟΗ2, Cl), (M-3129, H, CH3, Cl, MeOCH2CH2, F), (M-3130, H, GH3, Cl, MeOCIhCIh. CF3). (M-3131, H, CH3, Cl, MeOCH2CH2, Br), (M-3132, li, Oils, Cl, MeOCH2CH2, CHr〇, (M-3133, H, CH.3, Cl, HOCIh, II), (Μ-ίΠίΗ, II, Clla, Cl, HOCH2, Cl), (M-3135, H, CH.3, Cl, IIOCH2, F), (M-313G, 11, CIL·, Cl, HOCM2, CF；〇, (M-3137. H, CH3, Cl, HOCH2, Br), (M-3138, H, CII.m, Cl, IIOCII2, Clin), (Μ-313ί). H, CH^, Cl, IIOCH2CH2, Η), (M-3140, II, CII,% Cl, UOCII2CH2, Cl), (M-3141, H, CII3, Cl, HOCH2CH2, F), (M-3142, II, CHa, Cl, HOCH2CII2, CFa), (M-3143, H, CII3, Cl, HOCH2CH2, Br), (M-3144, II, CHn, Cl, 11()01120112, Cll：〇, (M-3145, II, CHn, Cl, HOCH2CH2CH2, Η), (M-3146, II, Clin, Ci, 11()0112〇112〇112) Cl), (M-3147, II, CHs, Cl, HOCH2CH2CH2, F), (Μ.：Π48, M, CU.m, Cl, IIOCH2CH2CH2. CF3), (M-3149, II, CH3, Cl, HOCH2CH2CII2, Hr), (Μ-：ΠΓ)0, II, Clht Cl, HOCH2CIl〇CH2. CII.3). (M-3151, H, CH.3, Cl, ΗΟΟϋ2〇1ΐ2〇Ιΐ2〇Μ2, II), (M-3152, H, Clla, Cl, HOCH2CH2CH2CH2, Cl), (M-315：i, II, CUm, Cl, II()Cll2CihCIl2CH2, F). (M-3151. H. CHs, Cl, HOCH2CH2CII2CII2, CKa), H, Clia, Cl, 1：55) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ----:----·-----裝---- (請先閱讀背面之注意事項再填寫本頁) 訂--- Φ 1284639 A7 B7 五、發明說明（“Ο HOCU2CH2CH2CII2, Br), (Μ-315β, II, CHn, Cl, HOGII2CII2CH2CM2. CH；〇. (M-3157, H, CII3, Cl, IIOCH2CM2CII2CM2CH2, II), (M-3158, II, Clh, Cl, HOCH2CH2CH2CH2CH2, Cl), (Μ-ίΜβΰ, II, CHn, Cl, IIOCH2CII2CH2CH2CH2. F), (M-3160, II, CH3, Cl, HOCH2CH2G[l2CIl2Cil2, CF3), (M-3161, II, CHa, CL IJOClhClhClbCIhivih, Hr), (Μ-；Π(ί2, II, CII；», Cl, 11( Hil h(JI luCI Ijdl I In, CHa), (M-3163, H, CH.3, Cl, llOClhCAUOClhClh, Η), (M-3164, H, CIi3, Cl. HOCII2CH2OCH2CH2, Cl), (M-3K55, H, Clla, Cl, HOCH2CII2OCH2CH2. F), (M-3166, H, CHa, Cl, ΗΟΟΗ2〇Η2〇ΟΙΐ2〇Ιί2, CFa), (M-3167, II, CAL·, Cl. HOCH2CH2OCH2CH2, Br), (M-31G8, II, CMn, Cl, MOCH2CH2〇CIl2CH2, CHr〇, (M-31G9, H, CH3, Cl, (Me)2N, H)，（Μ·317(>, H, CHa, Cl, (Me>2N, Cl), (M-3171· 11, CII.3, Cl, (Me)2N, F), (M-3172, H, CMn, Cl, (Mo)2N, CF3), (M-3173, II, CH3, Cl, (Me)2N, Br), (M-3174, H, GHa, Cl, (Mo)2N, CHa), (M.；U75, H, CHa, Cl, 哌啶-4-基甲基，Η), (Μ·317(5, Π, C丨U Cl,.哌啶-4-基甲基，Cl), (Μ·3177, H, CH3, Cl,哌啶-4-基甲基，F), (Μ·:Μ78, H, CH3, Cl， 哌啶-4-基甲基，、CF：〇, (Μ·3179, ΓΙ, (Tih，Cl,哌啶-4-基甲基，Br)， (M-3180, H, CH3, Cl,哌啶·4·碁甲基，CH:〇,（Μ·3181，H, CH3, Cl 環己基甲基，Η), (Μ-3182, Η,(〕丨h, Cl,環己基甲棊，Cl)，（Μ-3183· Η, CH3, Cl,環己基甲基，F), (M-;U84,丨丨，CHa, Cl,環己基甲基，CF3)， (Μ·3185, H, CH3, Cl,環己基甲基丨，Br), (Μ·318(ί, H, CH3, Cl， 環己基甲基，CH3), (Μ·3187, ΙΛ Π, U, [[，U)，（Μ-3188, F, Η，II，II，Cl)， (M-3189, MeO, F, Η, H, CF3), (Μ.：Π90, MoO, F, F, H, CFa), (M-3191, F, Η, Η, H, Br), (M-3192, F, Η, II, II, CII3), (Μ.；)1ί)3, P, II, H, F, Μ), (M-3194, F, Η, II, F, Cl). (M-3195, F, Η, H, F, F), (M-3196, Κ, Η, II, F, CFa), (M-3197, F, II, II, F, Br). (M-3198. F, Η, H, F, CHn), F, II, H, Cl, Η), (M-3200, MoO, F, II, II. n-Pr), (M-3201, F, Η, H, Cl, F), (Μ-：12()2, l·1, II, II, Cl, CKn), (M-3203, ΙΛ II, II, Cl. Br). (M-3204, F, H, II, Cl, CIIr〇, (M-3205, K, Η, H, CIJa, Η), (M-3206, F, H, II, 140 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ——l·---.-----·裝 (請先閱讀背面之注音？事項再填寫本頁) 訂--- 經濟部智慧財產局員工消費合作社印製 1284639 Δ7 A7 __ B7 五、發明說明（Μ ) (請先閱讀背面之注意事項再填寫本頁) CHs, Cl), (M-3207, F, Η, H, CH3, F), (M-3208, F, II, H, CII3, CF3), (M-32()9, F, H, H, CHi Br), (Μ·3210, F, Η, H, Gil·% (m.〇, (M·:以11，F，Η, H, Et, Π), (M-3212, F, Η, H, Et, Cl), (M-3213, F, Η, H, lit, l〇, (M-32H, F, Η, H, Et, CF3), (M-3215, F, Η. H, Et, Br), (M-3216, F, H, II, Et, CHa), (M-3217, F, Η, H, n-Pr, Η), (M-3218, F, II, II, n-Pr, Cl), F, II, II, n-IV, l〇, (M.；i22(), l·1, II, II, n-l'r, (ΜΛΟ, 經濟部智慧財產局員工消費合作社印製 (M-3221, F, Η, H, n-Pr, Br), (M-3222, F, Η, H, n-Pr, Clla), (M-3223, F, II, II, c-Pr, Η), (M-3224, F, Η, H, c-Pr, Cl), (M-3225, K, II, II, c-Pr, F), (M-322G, F, H, H, c-Pr, CF3), (M-3227, F, Η, H, cPr, Hr), (M-3228, F, Η, H, c-Pr, CHa). (M-3229, F, Η, H, i-Pr, Η), (M-3230, F, II, II, i-Pr, Cl), (M-3231, F, II, H, i-Pr, F), (M-3232, F, Η, H, i-Pr, CFs), (M.32H3, F, II, II, i-Pr, Br), (M-3234, F, 11, H, i-Pr, CH.3), (M-3235, F, Η, H, n-Bu, II), (M-3236, F, II, II, n-Bu, Cl), (M-3237, F, Η, H, n-Bu, F), (M-3238, F, II, II, n-Bu, CF：〇, (M-3239, F, Η, II, n-Bu, Br), (M-3240, F, Η, H, n-Bu, CHa), (M-3241, F, Μ, II, i-Bu, Η), (M-3242, F, II, H, i-Bu, Cl), (M-3243, F, Η, H, i-Bu, F), (M-3244, F, Η, H, i-Bu, CFa), (M-3245, F, Η, H, i-fiu, Br), (M-3246, F, Η, II, i-Hu, CII；〇, (M-3247, F, II, II, soc-Bu, II), (M-3248, F, U, II, sec-Bu, Cl), (Μ-：]2Ί{), K, II, H, rooBu, F), (Μ-；?250, K, Η, H. sec-Bu, CF3), (M-3251, F, Η, H, sec-Hu, Br), (M-3252, F, Η, II, sec-Bu, CH3), (M-3253, F, Η, H, n-Pen, Η), (Μ-32Γ>4, F, Η, II, n-Pen, Cl), (M-3255, F, Η, H, n-Pen, F), (M-3256, F, Η, H, n-Pen, CFa), (M-3257, F, Η, H, n-Pen, Br), (M-3258, F, IL H, n-Pen, CII3), (M-3259, F, II, II, c-Pon, If), (M-3260, F, II, H, c-Pon, Cl), (M-3261, F, Η, H, c-Pen, F), (M-3202, F, II, H, c-Pon, CFa), (M-3263, F, II, II, c-Pen, Br), (M-3264, F, H, II, c-Pon, CUn), (M-32G5, F, II, II, n-Ilox, H), (M-326G F, ll H, n-Hex, Cl), (M-3267, F, II, II, n-Ilox, F), (M-3268, F, Η, II, n-Hox. CF3), (M-3269, F, H, II, n-Hex, Br), (M-U270, l·1, 11, II, n-llox, ClI；〇, (M-3271, F, H, H, c-Hex, Η), (M-3272, F, Η, II, c-Mox, Cl), (M-；{27；3, F, II, II, c-IIox, F). (M-3274. F. H, II, c-Hex, CFa), (M-3275, F, II, II, ollox, Hr), (M-327G, F, Η. II, c-Hex. 141 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） A7 1284639 ___B7___ 五、發明說明（(Μ ) CII3), (M-3277, F, Η, H, OH, Η), (M-3278, F, H, II, OH, Cl), (M-3279. F. II H. OH. F), (M-3280, F, II, II, OH, CFa), (Μ-；3281, Κ, II, II, Oil, Br), (M-3282, F, II, H, Oil, CHs), (M-3283, F, Η, II, litO, U), (M-3284, F, II, H, EtO, Cl), (M-3285, F. Η, H, EtO, F), (M-3286, F, Η, H, EtO, CFn), (M-3287, F, Η, H, EtO, Br), (M-3288. F, H, II, KtO, Cll：〇f l·1, II, II, n-PrO, II), (M-M2i)(), l·1, II, II, n-PrO, Cl), (M-3291, F, Η, H, n-PrO, F), (Μ-32ί)2, F, II, II, n-PrO, CF3), (M-3293, F, ii, II, n-PrO, Br), (M-3294, F, Η, II, n-PrO, CII：〇, (Μ-32ί)Γ), F, Η, Γ1, PhO, Η), (Μ-32ί)β. F, II, H, PhO, Cl), (M-3297, F, H, Ht PhO, F), (M-32i)8, F, II, II, PhO, CF：〇. (M-3299, F, Η, II, PhO, Br), (M-3；30(), F, Η, II, PhO, CH,〇, (M-3301, F, H, II, BnO, II), (M-3302, F, Η, II, BnO, Cl), (M.3303, F, Η, II, BnO, F), (M-3304, F. H. H, BnO, CF3), (M-3305, F, II, II, BnO, Br), (M-3306, F, II, H, BnO, CII3), (M-3307, F, Η, H, PhCH2CH2〇, Η), (M-；}308, P, Η, II, PhCH2CH2〇, Cl), (M-3309, F, H，H，PhCH2CH2〇, F), (M-3310, l·' H, U, l)hCH2CH2〇, CF3)，（Μ-33Π, F, H，H, PhCH2CH2〇, Br), (M-3312, F, H, H, PhClhCthO, Clh)，（M-3313, MeO, II，II， CF30, CM3), (M-3314, F, Η, II, CFmO, Cl), (Μ-331Γ3, F, II, II, F), (M-331G, F? II, II, CFaO, CFs), (M-3317, F, H, H, CFaO, Hr), (M.；i318, F, II, II, CF3O, CII3), (M-3319, F, II, H, Ph, Η), (M-3320, K, H, II, Ph, Cl), (M-3321, F, H, II, Ph, F), (M-3322, F, Η, H, Ph, CFs), (M-332；], F, H, II, Ph, Br), (M-3324, F, Η, H, Ph. CH3), (M-3325, F, Η, H, 4-F-Ph, II), (Μ-3826, F, II, H, 4-F.Ph, Cl), (M-3327, F, IL II, 4-F-Ph, F), (M-3328, F, II, II, 4-P-Ph, CF：〇, (M-3：329, F, Η, II, 4-F-Ph, Br). (M-3330, F, Η, H, 4-F-Ph, CJI3), (Μ-；]3：η, K, II, II, 4.CF3.Ph, Η), (M-3332, F, H, H, 4-CFa-Ph, Cl), (M-3333, F, Μ, II, 4-CF3-Ph, F), (M-3334, F, II, II, 4-CFa.Ph, CF3), (M-3335, F, II, H, 4-CF,vPh, Hr), (M-333G, F, II, H, 4-CFs-Ph. Clh), (M-3337, F, II, H, 4-(Me)2N.Ph, Η), (Μ.；ί：]；{8, P, II, II, 4-(Mo)2N-Ph, Cl), (M-3339. F. II. H, 4-(Me)2N-Ph, F), (M-3340, F, li, il, 4.(Mo)2N.Ph, CFn)t (M-3341, F, H. El. 4-(Me)2N-i3h, Br), (M-3342, F, II, Ht d.(Mo)2N-Ph. Cll；〇, (M-3343. F, II, IL t- 142 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 裝----- (請先閱讀背面之注咅？事項再填寫本頁) 訂--- 鴯 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 _____ B7 五、發明說明（、仏） OH-Ph, Η), (M-3344, F, Η, H, 4-011.Ph, Cl), (Μ-334Γ3, F, II, II, 4-OH.Ph, P). (M-3346, F, Η, II, 4-OIi-Ph, CF.〇, (M.；3；M7, F, II, II, d-OH-Ph, Hr), (M-3348, F, Η, H, 4.〇H-Ph, CH3), (Μ-334Π, K, II, II, ii^-di-F-Ph, H), (M-3350, F. Π. H, 3.4-di-F-Ph, Cl), (M-3351, F, Η, II, ；},4.(li-F.Ph, F), (M-3352, F, II, H, 3,4-di-F-Fh, CFri), (M-3353, K, 11, II, ：1,4-ιΙί-Κ.|Μι, Hr), (M-：l：in4, II, II, ；M-di-K-Ph, CHa), (M-3355, F, Η, H, 4.COOII.PI1, II), (M.33G6, F, II, JI, 4.C00U.PH, Cl), (M-3357, F, II, H, 4-COOH-Ph, F), (Μ-3：ί58, F, II, II, 4.C00II-Ph? CF：〇, (M-3359, F, Η, H, 4-COOH-Ph, Br), (M-33G0, K, II, H, d-COOH-Ph, CII3), (M-33G1. F, Η, Η, Bn, II), (M-3362, F, Η, H, lin, Cl), (1^-3363, F, Η, II, Bn, F), (M-33G4, F, Η, H, Bn, CFa), (M-3365, F, Η, II, Hn, Br), (M-33G6, F, Η, H, Bn, CHs), (M-3367, F, Η, H, 4-F-Bn, Η), (M-3368, F, II, II, 4-F-Bn, Cl), (M-3369, F, Η, H, 4-F-Bn, F), (M-3370, F, Η, H, 4-F.Bn, CFn), (M-3371, F, Η, H, 4-F-Bn, Br), (M-3372, F, II, H, 4-F-Bn, CII3), (M-3373, F, II, II, 2-Py, II), (M-3374, F, II, II, 2-Py, Cl), (M-3375, F, Η, II, 2-Py, F), (M-3376, F, Η, H, 2-Py, CF3), (M-3377, F, II. H, 2-Py, Br), (M-3378, F, Η, H, 2-Py, CII3), (M-3379, P, Η, II, 3-Py. II), (M-3380, F, H, H, 3-Py, Cl), (M-3381, F, U, 11, ；3-Py, K), (M-3382, F, II, II, 3-Vy, CF；〇. (M-3383, F, Η, H, 3-Py, Br), (M-3384, F, II, II, 3-Py, Clla), (M-3385, 1Λ II, II, 4-Py, Η), (M-3386, F, II, II, 4-Py, Cl), (M-3387, F, Η, H, 4-Py, F), (M-3388, F, II. H, 4-Py, CFg), (M-3389, F, Η, II, 4-Py, Hr), (M-33i)0, F, Η, H, 4-Py, CII：〇, (M-3391, Ff Η, H, 2-Th, Η), (M-3392, F, II, II, 2-Th, Cl), (M-3393, F, Η, H, 2-Th. F). (M-3394, F, Η, H, 2-Th; CFn), (M-33f)5, F, Η, II, 2-Th, Br), (M-3396, F, Η, II, 2-Th, Glia), (M-3397, F, Η, II, 3-Th, U), (M-3398, F, II, II, 3-Th, Cl), (M-3399. F, Η, H, 3-Th, F), (M-3400, F, Η, II, ：]-Th, CF,〇, (M.；i40i, F, II, H, 3-Th, Br), (M-3402, F，Η, II, 3-Th, CH〇, (Μ·:Μ03, Κ, U, H,吡唑-2-基§ Π), (M-3404, F，Η· H, 吡唑-2_基，Cl)，（Μ-340Γ)，F，11, Π,吡唑-2-基，l·’)，（M-340G, F，H，II， 吡唑-2_基，CF3), (Μ·:Μ07, F，丨I· I丨，吡唑-2_基、Br)· (M-3408· F· Η· H，
\AD 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ----：----.-----裝---- (請先閱讀背面之注意事項再填寫本頁) 訂--- 經濟部智慧財產局員工消費合作社印製 1284639 Δ7 Α7 ______ Β7 ___ 五、發明說明（(“） 吡唑-2-基，CH3), (M-3409, F, Ιί，II，吡唑-3-基，1【)，（Μ·3410, F. II，H· 吡唑·3-基,Cl), (M-3411, F，11,丨丨，吡唑-3-基；K), (Mdm F, 1 丨，U， 吡唑-3_基，Ch)，（M-3413, P, II, 11,吡唑-3-基，Br)，（M-3414, P, Π， 吡唑-3-基,CH3), (M-3415, F, Η, Η,嘧啶-2-基，H), (M-341G，F，H，II， 嘹啶-2-基，C;l), (Μ-:⑷7, l·1, II, II，嘧啶-2-基，10, Κ，II，II， 嘧啶·2-基，CF3), (Μ·3419, F, II, ii,嘧啶-2-基，Br), (Μ·342(), l·’，Η，1ί， 瞭啶-2-基，CH3), (Μ-3421, l·，，丨丨，[1，嘧啶-4-基，II)，（Μ·3422, F, Η, II， 嘧啶-4-基，Cl), (Μ-3423, Κ，丨丨，Η，嘧啶-4-基，F), (M-3H1, F，丨丨· Π. 嘧啶基，CF3), (Μ·3425, F, Π, II，嘧啶-4-基，Br)，（Μ-;Μ2(5, F，Η，II, 嘧啶-4-基，CH3), (Μ·3427, F, II, 11，嘧啶-5-¾，H), (M-3428, F, Η, 11, 嘧啶-5-基，Cl), (Μ·3429, F, 1〖，丨I,峨啶-5-基，F)，（M-3430, F,丨I，H， 嘧啶-5-基，CF3), (M-3431，F,丨I, II,嘧啶-5·基，Br)，（M-3432, F，II，H， 嘧啶-5-基，CH3), (M-3433, F, II，H, HOOCClhCJhCIh，U)，（M-3434, F，II， H, HOOCCH2CH2CH2, Cl), (M-3435, F, Η, H, HOOCCH2CH2CH2, F), (M-3436, F, II, H, HOOCCH2CII2CH2, CFa), (M-34：37, F, II, II, MOOCCH2CM2CII2. Br), (M-3438, F, II, H, HOOCCH2CH2CH2, ClI：〇, (M.；M3i), F, II, II, HOOCCH2CH2CH2CH2, Η), (Μ-34Ί0, F, 11, H, IIOOCCH2CH2CH2CH2, Cl), (M-3441, F, II, II, HOOCCH2CH2CH2CH2, F), (M-3442, F, Η, II, HOOCCH2CH2CH2CH2, CFa), (M.；M4；3, F, II, II, IIOOCCII2CH2CH2CH2, Br), (M-3444, F, Η, H, HOOCCH2CH2CH2CH2, Clin), (M-3445, F, Η, II, (Me)2NCOCH2CH2CH2CIl2, II), (M-344G, K, if, II, (Mo)2NCOCII2CH2CH2CM2.
Cl)，（Μ·3447, F, Η, H, (Me)2NC()CihCIhCH2Cll2, l·’)，（Μ·ί3448, F, Η, H· (Me)2NCOCH2CH2CH2CH2, CR，〇, (Μ·ίΜ49, F,【【，II，（Me)2NCOCH2CIl2CH2CH2·
Br), (M-3450, F, II, Η, (Μθ)2ΝΟ()(：1Ι2〇ΙΙ2(ΜΙ2〇ΙΙ2, Clla), (M-；M51. F, H. H. (Me)2NCOCH2CH2CH2CIl2CIl2, II), (Μ-：ΗΓ>2, F, Π, II, (Me)2NCOCH2CH2CIl2CIl2CIl2, Cl), II, II, H4 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注音？事項再填寫本頁) 裝 -------· A7 1284639 B7____ 五、發明說明（(W ) (Me)2NCOCH2CH2CH2CH2CH2, F), (M.3454, II, U, (M€〇2NCOCH2CH2CH2CIhCIh, Cl·'”)，（Μ·:ΜδΓ), l·’，Η, II, (Me)2NCOCH2CIl2CH2Cil2CH2, Hr), (Μ.；ΗΓ)(5, K, II, II, (Me)2NCOCH2CH2CH2CH2CH2, CHa), (M-；M57, P, Η, II, MeOCIh, II), (M-3458, Ff II, JI, MeOCIh, Cl), ΙΛ II, II, MoOCIh, l〇, (M.；}4(J(), ΙΛ II, II,
MeOCH2, CFs), (M-3461, F, Η, H, MeOCii2, Br), (M-3462, F, Η, H, MeOClh, Clh), (M-3463, F, Η, H, EtOCII2, II), (M-：H64, F, II, 11, EtOCIh, Cl), (M-3465. F, II, H, EtOCH2, F), (M^UGCh F, II, II, IOt〇(^H2, (^Fa), (M-；M(57, F. U, II. p]tOCII2, Br), (M-3468, F, II, H, JOtOCHa, (：ll;〇, (Μ-；Η69, P, H, II, KtOCU2CH2, Η). (M-3470, F, Η, H, EtOCihCII^, Cl), (M-3471, F, II, U, EtOCH2CH2, F). (M-3472, F, Η, H, EtOCH2CH2, CPn), (M.3473, F, II, H, EtOCihClh, Br), (M-3474, F, Η, II, EtOCIhCih, Cllri), (Μ-347Γ), F, II, II, McOClhCIhOCIhCHo, II). (M-3476, F, Η, Η, ΜθΟΟΗ2〇Η2〇ΟΗ2〇1Ι2, Cl), (M-；M77, F, II, II, MeOCH2CH2〇CH2CH2, F), (M-3478, F, II, H, MoOCIi2CH2〇CIl2CH2. CFa), (M-3479, F, Η, II, MeOCIhClhOCIhClh, Br)，（Μ·;Μ80, P, 11，H， MeOCH2CH2〇CH2CH2, CH3), (M.3481, ΙΛ Μ, II, M0OOH2CH2, II), (M-3482, F, II, II; MeOCH2CH2, Cl), (M-3483, K, H, II, M0OCH2CH2, K), (M-3484. F, Η. H. ΜοΟΟΙΐ2〇Η2, CF.j), (M-3485, F, H, Η, Μο()ΟΠ2〇ΙΙ2, Br), (M-348G, F, Η, H. MeOCH2CH2, CH3), (M-3487, F, Π, II, 11()(^112, II), (M-3488, F, II, II, HOCIh. Cl), (M-3489, F, Η, H, HOCH2, I〇, (Μ-：}^9(), ΙΛ II, ll IIOCH2. CFa), (M-3491, F. Η, II, IIOCH2, Br), (M-3492, F, II, H, HOCIh, CII3), (M-；M93, F, IL II, HOCH2CH2, II), (M-3494, F, Η, II, HOC1I2CII2, Cl), (M-3495, F, II, IL HOCH2CH2, F), (M-349G, F, II, H, MOCH2CH2, CFa), (M-3497, F, Η. H, IIOCII2CH2, Br), (M-3498, F, H, U, IIOCH2CII2, (M-；Mi)5). F, Η, H. IIOCH2CH2GII2, II), (M-3500, K, II, II, II()C1I2(>I12CII2, Cl). (M.3501, F, II. H. HOCII2CH2CH2, F), (M.3502, F, II, II, IIOCII2CH2CH2, CF：0, (M-3503, F, Η. H. H5 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） " ---U---->·-----裝---- (請先閱讀背面之注意事項再填寫本頁) 訂--- 峰· 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、發明說明) nOClUClhClh, Br), (M-3504, F, H, II, IIOCH2CH2CII2, CU,〇, (Μ-3Γ)0Γ), F, II, H. ΗΟ(；Ιΐ2〇Η2〇Ιΐ2〇Η2, H), (M-3f)0(5, l·1, ll, H, ll〇Cll2Cil2Cll2CIl2, Cl), (M-；3507, F. II. H, IIOCH2CH2CH2CH2, F), (M-U508, K, II, H, IIOCH2CH2CH2CH2, CF：〇, (Μ·3509, F，Η, H，HOCH2CH2(〕H2()H2, Br), (Μ·3Γ)10, F, li，H， HOCH2CII2CH2CM2, CAh)f (M.U5II, K, II, II, !l()(Ml2(ill2〇ll2(3ll2(：ll2, II), (M-3512, F, H, H; HOCH2CH2Cli2CIl2CH2, Cl), (M-3513, F, Η, H, Η〇αΗ2(〕Π2(〕Η2(〕Π2(〕ΐί2, ία 个 K,丨I，丨I，11()(川 (M-3515, F, II, Π, HOCIi2CH2CH2OII2CII2, Hr), (Μ-3Γ)10, F. Η, H, HOCH2CH2CH2CH2CIl2, CH3), (Μ-3Γ)17, F, II, ii, Il()Cll2Cll2()Cll2CH2. H). (Μ·3518, F, Η, H, HOCH2CII2OC：IhCih，Cl), (M-3519, F, II，H, HOCH2CH2OCH2CH2, F), (M-3520, F, II, U, HOCH2CH2OCH2CH2, CFa), (M-3521, F, Η, H, HOCH2CH2OCJI2CH2, Hr), (M-3522, F, II, H, H0CII2CH20CH2CH2, CII3), (M-3523, F, Μ, II, (Mo)2N, Η), (M-3524, F, II, H, (Mc)2N, Cl), (M-3525, F, Η, II, (Mo)2N, l〇, (M-352G, F, Η, H, (Mo)2N. CF3), (M-3527, F, Η, II, (Me)2N, Br), (M-3528, F, II, II, (Mo)2N, CHs), (M-3529, F, H, H，哌啶-4 _基甲基，II), (M·;偏0, F, II,丨丨，哌啶-4 -基甲基，Cl)， (M-3531, F, Η, H，哌啶-4 -基甲基 1, F), (Μ·3532, F, 11，H，哌啶-4 -基 甲基，CF3), (M-3533, F, II, II，哌啶-4 -基甲基，Dr), (M-3534, F，II，Η， 酿啶基甲基，CI1A (Μ·:·5, IV丨丨，丨丨，環己基甲基，丨丨)，（Μ·3Γ)3(;· F, Η，Η，環己基甲基C丨)，（Μ·3Γ)37, Ρ,丨丨，丨【，環己基甲基，〇，（1^-3.538, F, Η，Η,環己基甲基，CR*〇, (Μ·3Γ)39, Ρ, Η· Η,環己基甲基，Br)， (Μ·3Γ)40, F，II，Η,環己基甲基，C11·”)，（Μ-·3Γ)41，P, H, F，H，H)，（M-3542, F， H, F, Π, Cl), (Μ-3543, F, Η, F, II, I〇t P, II, F, [I, CFa). (M-3545. F. H. F, II, Br), (M-3546, F, II, F, II, (Mia), (Μ.：}Γ>47, ΙΛ II, F, F, II), (M-3548, P. II. F. F, Cl), (M-3549, F, H, F, F, F), (Μ.：]Γ)50, ΙΛ li, ΙΛ K, (ΜΛ〇, (Μ-3Γ)Γ>1, b\ II, K, F. Br). (M-3552, p, H, F, F, CAL·), ΙΛ 11, ΙΛ Cl, II), (M-3554, F, ll F, Cl. Cl). Η(ί 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁)
-- I I I
« — — — — I 1284639 LK.1 t A7 B7 五、發明說明（ιβ) ίΜ-3555, F, If, F, Cl, F), (Μ-35Γ)0, P, II, K, Cl, CPa), (Μ.3Γ)Γ>7, F. II. P. Cl. Br), (M-3558, F, H, F, Cl, CH3), (Μ-3Γ)51), P, II, K, CAL·, II), (M-；35G(), F, II, F, CII3. Cl), (M-3561, F, H, F, CHa, F), (M-35G2, F, II, F, CHa, CFa), (M-3563, F, II, F, CH3. Br), (M-3564, F, H, F, CH3, CIIb), (M.3565, F, II, F, Et, Η), (M-3566, F, II, F? Et, Cl), (M-35G7, F, JI, F, JOt, l〇, (Μ-：ΙΓ)(；Η, l·1, II, K, Kt, (：ΙΛμ), K, II, K,
Et, Br), (M-3570, F, H, F, Et, CII3), (M.；3571, F, H, F, n-Pr, Η), (M-3572, F, li, F, n-Pr, Cl), (M-3573, F, il, F, n-Pr, l〇, (M-；{574, F, Π, F, n-Pr, CF；〇. (Μ-3575. F. II, F, n-Pr, Br), (M-3576, F, Η, K, n-Pr, CII；〇, (M.；]577, F, II, F. c-Pr, II), (M-3578, F, H, F, c-Pr, Cl), (Μ.357ί), K, Η, P, c>Pr, F), (M.3580, F, H, F, c-Pr. CF3), (M-3581, F, H, F, c-Pr, Br), (Μ-3Γ)82, ΙΛ II, F, c-Pr, CM3), (M-3583, F, H, F, i-Pr, Η), (M-3584, F, H, F, i-Pr, Cl), (M-3585, F, II, F, i-Pr, F), (M-3586. F, H, F, i-Pr, CFa), (M-3587, F, II, F, i-Pr, Br), (M-3588, F, Μ, P, i-Pr, CII；〇, (M-3589, F, II, F, n-Bu, II), (M-3590, F, M, F, n-Hu, Cl), (Μ-3Γ)91, F, 11, F, n-Bu, F), (M-3592. F, H, F, n-Bu, CF3), (M-3593, F, 11, F, n-Hu, Br), (M-3594, F, H, F, n-Bu, Clla), (M-3595, F, H, F, i-Bu, H), (M-359(5, F, II, F, i-Bu, Cl), (M-3597, F, II, F, i-Bu. F), (M-3598, F, H, F, i-Bu, CFa), (M-3599, P, II, F, i-Hu, Br), (M-3G00, F, 11, F, i-Bu, CHa), (M-3601, F, II, F, roc-Hu, JI), (M-；Ui()2, F, 11, ΙΛ boc-Bu, Cl). (M-3(503. F. H, F, sec-Bu, F), (M-3604, F, H, K, hoc-Hu, CF:〇, (M.；K505, F, II, F, sec-Hu. Hr), (M-3606, F, II, F, sec-Bu, CHn), (M-：3(507, ΙΛ 11, l·1, n-Pon, H), (M-3(>08, F, II, F, n-Pen, Cl), (M-3609, F, H, F, n-Pen, F), (M-iJGK), P, H, F, n-Pen, CFa), (Μ-：3611, F, H, F, n-Pen, Br), (M-3612, F, II, F, n-Pon, Clla), (M-3613, F, II, F, c-Pen, H), (M-3614, F, Η, F, c-Pen, Cl), (Μ.；ΗΠ5, K, II, F, c-Pon, F), (M-361G, F, H. F, c-Pen, CF.〇, (M-3617, F, H, F, c-Pon, Hr), (M-：U518, F, II, F, c-Pon, CII^), (M-3619. F. H? F, n-Hex, Η), (M-3620, F, II, F, n-ilox, Cl), (M.；U521, P, II, F. n-IIox, F), (M-3622, F, H, F, n-IIex, CKn), ΙΛ U, F, n-Ilox, lir), (M-；U>24t F, H. F. n-IIex, CH3), (M-3625, F, II, F, c-IIox, II), (M-8G2G, F, 11, F, c-IIox. Cl), (M-3G27. 147 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） -------------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 經濟部智慧財產局員工消費合作社印製 A7 ___B7_ 五、發明說明Ο#) F, U, F, c-IIex, F), (M-3628, F, II, ΙΛ c-llox, CK；〇, (Μ.：Η529, ΙΛ II, F. c-Hex. Hr). (M-3G30, F, II, F, c-Hex, CH：〇, (Μ-：](；；Π, F, II, F, Oil, II), F, H, F, OH,
Cl)? (M-3633, F, H, F, OH, F), F, Π, F, OIL CF：〇, (Μ.；3()3Γ), F, H, F. OH.
Br), (M-3636, F, H, F, OH, CII3), (M-3637, F, II, F, EtO, H), (M-3638, F, II, F, EtO, Cl), (M-3G39, F, II, P, KlX), l·1), l·1, II, F, KU), (ΊΛ0, K, 11, F, EtO, Br), (M-3642, F, H, F, EtO, (：ίΙ；〇, (M-3643, F, II, F, n-PrO, 11), F, H, F, n-FrO, Cl), (Μ-：Κ)^1Γ,, P, II, n-PrO, F), (M-H(H(5, F, II, F, n-PrO. CF;0. (M-3647, F, II, F, n-PrO, Br), K, II, F, n-PrO, CII；〇, F, IK F.
PhO, II), (M-3650, F, H, F, PhO, Cl), (M.3G51, K, II, P, PhO, F), (M-3652, F. H. F? PhO, CF3), (M-3653, F, H, F, PhO, Br), (M-3654, F, 11, F, PhO, CII3), (M-3655, F? H, F, BnO, Η), (M-3656, F, H, F, BnO, Cl)t (M-3G57, F, II, F, BnO, F), (M-3G58, F, U, F, BnO, CF3), (Μ-3β5ί), P, Π, K, HnO, Hr), (M-3G60, F, II, F, BnO. CH3), (M-3661, F, H, F, PhCrhClhO, II), (M-36G2, F, II, F, PhCIl2CH2〇. Cl). (M-3663, F, H, F, PhCH2CH2〇, F), (M-36G4, F, II, F, PhCH2CH2〇, CF3), (M-3665, F, II, F, PhCH2CH2〇, Br), (M-3(；66, F, Π, F, 1^0112〇112〇, die), (M-36G7, F. H, F, CF3〇, Η), (M-3668, F, II, F, CFnO, Cl), (M.；3(5G9, F, H, F, CFaO, F), (M-3670, F, H, F, CFsO, CF3), (M-3(}71, F, 11, F, CFaO, Br), (M-3672, F, II, F. CF3O, CHn), (M-3673, F, II, F, Ph, II), (M.：3G74, F, II, F, Ph, Cl), (M-3675, F, H. F. Ph, F), (M-3676, F, H, F, Ph, CKn), (M-3G77, F, Η, K, Ph, Br), (M-3678, F, II, F. Ph, Cil.3), (M-3679, F, II, F, 4-P-IVh, II), (M-3680, F, H, F, 4-F-Ph. Cl), (M-3681, F, H, F, 4-F-Ph, F), (M-3682, P, II, K, 4-F.Ph, CFs), (M-3683, F, II, F, 4-F-Ph, Br), (M-3684, F, H, F, 4-F.Ph, Clin), (Μ-3Γ>8Γ), ΙΛ H, F, 4-CF3-Ph. H). (M-3686, F, H, F, 4-CF3-Ph, Cl), (M.：l(587, K, II, F, d-CFa-Ph, F), (M-3688, F, H. F, 4-CF3-Fh, CFn), (M-8689, F, II, K, Hr), (M-3Gi)(), ΙΛ II, ΙΛ 4-CFa-Ph, CII：3), (M-3691, F, II, F, 4.(Μο)2Ν.Πι, II), (M-：}(；i)2, V\ U, F, 4-(Μο)2Ν-ΓΗ, Cl), (M-3693, F, H, F, 4.(Me)2N-Ph, F), ΙΛ II, F, 4-(Mo)2N-Ph, CF3), (M- 148 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ----：---.-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) A7 1284639 B7 _ 五、發明說明（） 3G95, F, H, F, 4.(Mo)2N.Ph, Br), (Μ-：Η；?)(5, ΙΛ II, ΙΛ 4.(Mo)2N.Ph, (^1；〇. F. H, F, 4-OH.Ph, H), (M-3(；98, F, H, F, 4.()1Ι-ΙΜι, Cl), (M-3G99, F, 11, F, 4-OH-Ph, F), (M-3700, F, H, F, 4.〇II-Ph, CF3), (M-3701, F, II, F, 4-OH-Ph, Br), (M-3702, F, H, F, 4-OH-Ph, CH3), (M.370：3, F, H, F, 3,4-di.F.Ph, Η), (M-3704, F, II, F, 3,4.ϋ!-Κ-Ηι, Cl), (Μ-：}70Γ), l\ II, Μ^μΙϊ-Κ-Πι, l〇, ΙΛ II, K, 3,4-cli-F.Ph, CFs), (M-3707, F, H, F, 3,4.(li.F.Fh, Hr), (M-3708, F, H. F, 3.4-(li-F-Ph, CII3), (M-3709, F, H, F, 4.(：()0!ΜΜι, II), (M-3710, K, II, F, 4-COOH.Ph, Cl), (M-3711, F, H, F, 4-COOlI-Ph, F), (Μ-；{712, F, H, F, 4-ΟΟΟΗ-Ρ1ι, CF：〇, (M-3713, F, H, F, 4-00011-1^, Br), (M-3714, P, II, F, d-COOII-Ph, CAL·), (M-3715, F, H, F, Bn, Η), (M-3716, F, H, F, Bn, Cl), (M-3717, F, H, F, Ba, F), (M-3718? F, II, F, Bn, CF3), (M-3719, F, H, F, Bnf Hr), (M-3720, F, II, F, Bn, CII3), (M-3721, F, H, F, 4-F-Bn, Η), (M-3722, P, H, F, 4.PvHn, Cl), (M-3723, F, II, F. 4-F-Bn, F), (M-3724, F, II, F, 4-F-Hn, CFn), (M-3725, F, II, F, 4-F-Bn, Hr), (M-3726, F, II, F, 4-F-Bn, CH3), (M-3727, F, II, F, 2-Py, II), (M-3728, F, II, F, 2-Py, Cl), (M-3729, F, H, F, 2-Py, F), (M-；{730, F, II, F, 2-Py, (M-3731, F, H, F, 2-Py, Br), (M-3732, F, H, F, 2-Py, CHr〇, (M-3733, F, II, F, 3-Py, II), (M-3734, F, H, F, 3-Py, Cl), (M-3735, F, II, F, ；Μ»γ, K)t (M.；37；36, F, Η, K, 3-Py. CF^). (M-3737. F, II, F, 3-Py, Br), (M-3738, F, II, ΙΛ ；l-Py, (^lI；〇, (M-；17U!), ΙΛ II, F, 4-Py, II), (M-3740, F, H, F, 4-Py, Cl), (M-3741, F, U, F, 4-Fy, K), (M-3742, F, II. F, 4-Py. CPs), (M-3743, F, H, F, 4-Py, Or), (M-3744, F, H, F, 4-Py, CII,〇, (M-3745, F, H, F, 2-Th, Η), (M-3746, F；H, F, 2-Th, Cl), (M-3747, F, H, F, 2-Th, F), (M-3748. F, H, F, 2-Th, CF,3), (M-3749, F, II, F, 2-Th, Hr), (Μ-；Π50, F, Ii, F, 2-Th. CAL·), (M-3751, F, II, F, 3-Th, Η), (Μ-：}7Γ,2, \<\ II, F, 3-Th, (Μ), (Μ-；Π53, F, H. F. 3-Th, F), (M-3754, F, H, F, 3-Th, C^；〇, (Μ.：ί7Γ)Γ), F, |[, F, ；}-Th, Hr), (M.；i75(；, F, II. F, •3-Th，Clh)，（M-37/37, F, H, F，吡唑-之-基乂⑴，（Μ-:37Γ】8, F, 11, F·批唑-2-基，Cl)，（Μ·37Γ)9, F, H，F，吡唑-2-基，l·’)，（Μ·;37(;(), F，II, l·’.吡唑-2-基 k CF3),
Hi) 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ---:-----------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7
五、發明說明（Kef ) (M-37Gi，p，H，F，吡唑-2-基，Br), (Μ·:Γ7(;2, F· I丨，Κ·吡唑-2-基，CH·,)· 經濟部智慧財產局員工消費合作社印製 (Μ·3763’ ρ，Η，F，_壯唑-3-棊，il), (Μ·37(Μ，Ρ，11，l·' 吡唤-3-華，Cl)，（Μ· 3 …5, F，H，F，吡唑- 3-.基 F)，（M-:!7G(5, F，11, F，吡唑-3-棊,，CF:〇, (M-37G7, F· H，F，吡唑-3·基 Br), (M-37G8, P,丨I, l·' 吡唑-3_基，Clh), (M-37G9, F，H， tl定，2-基，II), (Μ-377(), K，II，K，嘧啶-2-棊，Cl)，（M-;177I，K，II，K， 嘛唆·2·基， F), (M.3772, F, H，K，嘧啶-2-基，CF.3), (Μ·377:3, F, 11，K 瞭啶-2·基，Br), (Μ-3774, F，II，ΙΛ 嘧啶-2-基，Clh)，（Μ·;Π75, F, Η, Ρ, 哺啶·4·基， Η), (M-377G, F，Η，IV 略陡·4-基，（】1)，（Μ-3777, F，11，F, 瞭陡·4·基，F)，（Μ-3778, F，η, κ，嘧啶.4_基，CF3) (M.3779 F H F 1瞭陡-4·基，Br)，（M-3780, F, 11, F，嘧啶-4-基，Clh)，（M-3781，F，H, F, 嘧啶-5·華，H)，（M.3782, F，Η, K,嘧啶-5-基，Cl)，（M-3783, F, Π, F, 嘧啶·5·基，F), (M-3784, l·' 丨丨，F,嘧啶-5-基，（於)，（M-3785, l·' U, F. 嘧啶-5-基，Br)，（M-378G, F，II, F,嘧啶-5-基，CU3), (M-3787, F，II. F， HOOCCII2CH2CH2, Η), (M-3788, F, II, F, IIOOCCII2CH2CH2, Cl), (M-3789, F, H, F, HOOCCH2CH2CH2, F), (M-37i)0, F, II, F, IIOOCCH2CII2CH2, CFa), (M-3791, F, H, F, HOOCCH2CH2CIl2, Hr), (M-375)2, F, II, F, UOC)CClI〇Cll2CH2. CH3), (M-3793, F, II, F, HOOCCII2CH2CH2CII2, 11), (M-3794, F, II, F, IIOOCCH2CH2CII2CH2, Cl), (Μ-37ί)Γ), F, H, F, ΙΙ()0(^ΟΗ2〇Ιΐ2〇Π2〇Π2, F), (M-3796, F, H, F, HOOCCH2CH2CH2CII2, ΟΙΛ·〇, (M-3797, F, II, F, HOOCCII2CH2CH2CH2, Br), (Μ-37Π8, F, II, F, HOOCClhCIhCIhCIh, CH3). (Μ·3799, F, H, F, (Me)2NCOClI2ClhClhCH2, H)，（Μ·3800, F, II，F, (Me)2NCOCH2CH2CH2CH2, Cl), (M-3801, ΙΛ Μ, ΙΛ (Μο)2ΝΟΟΟΗ2〇Η2〇Η2〇Η2. F), (M-3802, F, H, F, (Μο)2ΝΟ()ΟΙΐ2〇ΙΙ2(>Ιΐ2(Μΐ2, CKm), (M-：i80；3, F, H, F. (Mo)2NCOCIl2CH2CIl2CH2, Hr), F, H，(M(〇2NC()CH2CU2Clli>Cll2. CH：〇. (M.3805, F, H, F, (Μο)2Ν(：()(：Ιΐ2〇1ΐ2(Μΐ2('Ιΐ2〇Ιΐ2, H), (M-：}80(>. F. 11. F. (Me)2NCOCH2CH2CIl2CH2CH2, Cl), (M.：?807, F, Π, F, 150 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 ___B7 _ 五、發明說明（^?) (Mo)2NCOCIl2CIl2CH2CH2CH2, I〇, (M-H808, ΙΛ Η, ΙΛ (Me)2NCOCH2CH2CH2CH2(〕H2,（Μ·38()ί)，F，11，l·' (Me)2NCOCH2CH2CH2CH2CIl2, Hr), (M-3810, F, M, F, (Me)2NCOCH2CH2CH2CH2CIl2, Clin), (M-381 1, F, II, P, MeOCH2, Η), (M-3812. F, II, F, MeOCIh, Cl), l·1, II, l·1, MeOClh, l·1), (Μ-Μ8Η, II, ΙΛ
MeOCII2, CF.3), (M-3815, F, II, F, ΜοΟΟΠ2, Rr), (M-3816, F, II, F, MeOCPh. CII3), (M-3817, F, H, F, Et()CH2, II), (M-3818, F, II, F, litOClh, Cl), (M-3819, F. H, F, EtOCH2, F), (M-3820, F, II, l·1, KtOCIl2, CF：〇, (M-3821, F, II. F. KtOCIl2, Br), (M-3822, F, H, F, EtOCH2, CII：〇, (M-3823, P, H, F, litOCH2CM2. H). (M-3824, F, H, F, EtOCH2CH2, Cl), (M-3825, F, II, F, ΕΐΟΟίΙ2ΟΙΐ2, F), (M-3826. F, H, F, EtOCH2CH2, CF3), (M-3827, F, U, K, KtX)CII2CM2, Rr), (M-3828, F, II, F. EtOCH2CH2, CH3), (M-3829, F, II, ΙΛ Mi^CAUCA^CAUClU, Η), (M-3830, F. II, F? MeOCH2CH2〇CH2CH2, Cl), (M.：}8：U, F, II, F, M0OCII2CII2OCII2CH2, F), (M-3832, F, H，F, MeOCiI2CH2〇ClI2CH2, CF:〇,（M-3833, F, II，F\ MeOCIl2CH2〇CH2CH2, Br), P, II, F, Μο()ϋΙ[2〇Η2〇ΟΗ2〇Η2, CHa), (M-3835, F, H, F, MeOCIhCIh, II), (M-383G, F, II, F, M0OCH2CH2, Cl), (M-3837, F, H, F, MeOCH2CH2, F), (M-3838, F, II, F, M0OCH2CH2, CFa), (M-3839, F, H, F, MeOCH2CH2, Br), (M-3840, F, H, F, MeOCHaCHa, CH3)，（M-3841，F，H， F, HOCH2, Η), (M-3842, F, H, F, IIOCH2, Cl), (M-3843, F, H, F, HOCH2, F), (M-3844, F, H, F, HOCH2, CF3), (M-3845, F, H, F, IIOCH2, Br), (M-3846, F, II. F, HOCH2, CH3), (M-3847, F, II, F, IIOCII2CII2, H), (M-3848, F, H, F, IIOCH2CH2, Cl), (M-3849, F, Η, K, HOCH2CII2, F), (M-3850, F, II, F, HOCII2CII2, CF3), (M-3851, F, II, K, IlOOIhCII2, Br), (M-3852. F, H. F, IIOCII2CH2, CH3), (M-3853, F, II, P, llOCIbCIhCUa, Η), (M-3854, II, F, HOCH2CH2CH2, Cl), (M-3855, F, Π, K, IIOCH2CH2CH2, P), (M-3856, F, H, F. HOCII2CH2CH2, CFn), (M-3857, F, II, l·；, IIOCHsCIhCfh, Br), (M-3858. F, II. F, 151 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ----1----I------------訂---- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五、發明說明（…） HOCH2CII2CH2, CAU), (Μ-：38Γ)9, F, II, P, [|()CH2CIl2(^ll2CH2, M), (M-38G0, Ρ, Η. F. HOCH2CH2CH2CH2, Cl), (Μ.3861, F, II, F, ΙΙΟΟΗ2〇Η2〇ίΐ2〇ίΐ2, F), (Μ-3862. F, Η, F, HOCH2CH2CH2CII2, CFr〇, (Μ.386；), ΙΛ II, F, IIOCH2CH2CII2CII2, Br), (Μ-3864, F, Η, F, HOCII2CH2CH2CH2, 〇Π,〇, (Μ-380Γ), F, Η, F. UOCH2CII2CH2CII2CU2, 11), (Μ.；!8(；(；, l\ II, ΙΛ 11〇(：112(：112(：111!('11»(：111., CD, (Μ·3867, F, Η, F，HOCthClhCihCfhCIh，F), (Μ·3868, F，Η，F, HOCII2CH2CH2CH2CH2, CFn), (M-:18(59, K, II, F, 11()(：112〇112〇112〇112〇112. Br). (Μ·3870, F, H, F, HOCIhCihC^ClhCIh, CH3), (M-3871, F, il, F· HOCH2CH2OCH2CH2, Η), (M-3872, F, H, F, HOCH2CH2OCH2CH2, Cl), (M-3873, F, H, F, HOCH2CH2OCH2CH2, F), (M-3874, F, H, F, HOCH2CH2OCH2CH2, CF3), (M-3875, F, H, F, HOCH2CH2OCH2CII2, Br), (M-3876, F, H, F, HOCH2CH2OCH2CH2, CHr}), (M-3877, F, H, F, (Mo)2N, Η), (M-3878, F, H, F, (Me)2N, Cl), (M-3879, F, II, F, (Mg)*2N, F), (M-3880, F, II, F, (Me)2N, CF；〇, (M-3881, F, H, F, (Me)2N, Br), (M-3882, F, H, F, (Mo)2N, CII3), (M-3883, F, H, F, 峨啶-4-基甲基，Η), (M.388个F, H, F,哌啶-4-基甲基，（〕1)，（1^· 3885, F，H, F,哌 Π定-4-基甲基，F)，(M-;Μ8Γ)，Ι，'Η，Κ，ι)ή)(νι·ί(Ηη·4·γ1-methyl，CF3), (M-3887, F, Η，[V 哌啶-4-基甲基，Br), (Μ-3888上 哌啶· 4 -基甲基，Clh)，（Μ-3Η89, Κ,丨丨，F，環己基甲基L Η), (Μ·3890, F, H, F,環己基甲基，Cl), (MdmU, F, II，F,環己基甲基，F)，（Μ·3892, F. H，F，環己基甲基，CF·3)，（Μ·3893，Ρ，H，F，環己基甲基，3|〇，（\1-3894, F, H, F,環己塞甲基，ΟΠΟ,（Μ·389Γ)，丨1，（〕1，Η, H)，（M-38i)G，F，Η, Cl, II, Cl), (M-3897, F, II, Cl, H, F), (M-3898, K, H, Cl, II, CF；〇, (M-3899, F, H, Cl, H, Br), (M-3900, F, H, Cl, II, Clin), (M.3901, F, II, Cl, F, II), (M-3902. F. H, Cl. F, Cl), (M-3903, F, II, Cl, F, F), (Μ-ίΗ)Ο^, K, II, Cl, F, CFa), (M-3905, F, II. Cl, F, Br), (M-3906, F, H, Cl, F, CII：〇, (M-3907, F, II, Cl. Cl, II), (M-3908. F, H. Cl. Cl, Cl), (M-3909, F, II, Cl, Cl, F), (M-3910, Π, Cl, (>I, CF.〇, (M-3911. F, II. Cl, 152 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） -----翁 (請先閱讀背面之注音？事項再填寫本頁) tr--------- 經濟部智慧財產局員工消費合作社印製 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（^ )
Cl. Br), (M-3912, F, H, Cl, Cl, CII：〇, (Μ-：}ί)18, F, II, Cl, CMm, II), (M-3i)M, F, H, Cl. CH3, Cl), (M-3915, F, II, Cl, CAL·, F), (M-3i)1G, F, II, Cl, CHa, CP；〇, (M-3917, F? H, Cl, CII3, Br), (M-3918, K, H, Cl, CIIm, (Μ.：Μ)1ί), K, II, CK Kt, Π). (M-3920, F, H, Cl, Et, Cl), (M-3921, II, Cl, Kt, F), (M-3922, F, II, Cl, Et, CFa). (M-3923, F, H, Cl, Et, Br), l·1, II, Cl, Kt, (Μ-；5!)2Γ), l\ II, Cl, n-Pr, H), (M-3926, F, H, Cl, n-Pr, Cl), (M-3927, F, II, Cl, n-Pr, F), (M-3928, F, H. Cl, n-Pr, CFa), (M-3929, F, H, Cl, n-Pr, Hr), (M.：U)：30, F, ll Cl, n-Pr, CH；〇, (M-3931. F, II, Cl, c-Pr, H), (M-3932, F, tl, Cl, olV, Cl), (Μ-：Μ)；]3, l·：, II, Cl, c-Pr, F), (M-3934, F, H, Cl, c-Pr, CF3), (M.：U)35, II, Cl, c-Pr, Br), (M-3936. F, II, Cl, c-Pr, CHa), (M-3937, F, H, Cl, i-Pr, Η), (M-3938, F, H, Cl, i-Pr, Cl), (M-3939, F, H, Cl, i-Pr, F), (M-3940, F, H, Cl, i-Pr, CFa), (M-3941, F, H, Cl, i-Pr, Br), (M-3942, F, H, Cl, i-Pr, CHs), (M-3943, F, II, Cl, n-Bu, Η), (M-3944, F, H, Cl, n-Bu, Cl), (M-3945, F, H, Cl, π-Bu, F), (M-3946, F, H, Cl, n-Bu, CF3), (M-3947, F, H, Cl, n-Bu, Br), (M-3948, F, H, Cl, n-Bu, CHa), (M-3949, F, II, Cl, i-Bu, Η), (M-3950, F, H, Cl, i-Bu, Cl), (M.3951, F, II, Cl, i-Bu, F), (Μ-39Γ>2, F, II, Cl, i-Bu, CF3), (M-3953, F, H, Cl, i-Bu, Br), (Μ-：3ί)Γ)/1, P, H, Cl, i-Bu, ΟΠ：〇, (M-3i)55. F. H. Cl, sec-Bu, Η), (M-3956, F, H, Cl, boc-Hu, Cl), (M.3957, F, H, Cl, soc-Bu, F), (M-3958, F, H, Cl, sec-Bu, CF.〇, (Μ.395Γ), F, II, Cl, roc-IUi, Br), (M-39G0, F, II. CL sec-Bu, CH.3), (M-3961, F, II, Cl, n-Pon, II), (M-3962, F, II, Cl, n-Pon, Cl), (M-3963, F, H, Cl, n-Pen, F), (M-；ii)G4, K, II, Cl, n-Pon, CFa), (M-3965, F, II, Cl. n-Pen, Br), (M-3966, F, II, Cl, n-Pon, CII；〇, (M-：3i)G7, F, II, Cl c-Pen, II), (M-3968, F, II, Cl, c-Pen, Cl), (M-39()9, F, H, Cl, c-Pon, l〇, (M-3970, F, II, Cl, c-Pon, CF：3), (M-3971, F, H, Cl, c-Pon, Hr), (M.：)i)72, F, II, Cl, c-I^n, CII：〇. (M-；i97；V F. H, Cl, n-Hex, Η), (M-3974, F, II, Cl, n-IIox, Cl), (Μ-：Μ)7Γ3, F, II, Cl, n-Hox, F), (M-3976, F, H, Cl, n-IIex, CP3), (M-3f)77, F, 11, Cl, n-IIox, Br), (M-3978, P. H, Cl. n-Hex, CH3), (M-3979, F, H, Cl, ollox, II), (M.：M)80, F, II, Cl, c-IIex, Cl), (M- 1 53 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ^ ·-------------訂 --------- (請先閱讀背面之注咅？事項再填寫本頁) 1284639 A7 經濟部智慧財產局員工消費合作社印製 ___B7_五、發明說明（li^) 3981, F, H, Cl, c-Hex, F), (M-3982, F, H, Cl, c-Ποχ, CF3), (M-3983, F, H, Cl. c-Hex, Br), (M-3984, F, H, Cl, c-Hex, CHa), (M-3985, F, H, Cl, OH, Η), (M-3986, F, H, Cl, OH, Cl), (M-3987, F, H, Cl，OH, F), (M_3988, F, H, Cl, OH, CF3), (M-3989, F. H, Cl, OH, Br), (M-3990, F, H, Cl, OH, CII3), (M-3991, F, H, Cl, EtO, H), (M-3992, F, H, 〇), KtO, Cl), ΙΛ II, Cl, 10. (Μ-：ί1)ί)Ι, ΙΛ II, (Ί, MlO, CFa), (M-3995, F, H, Cl, EtO, Br), (M-3996, F, II, Cl, EtO, CJI3), (M-；3997t F, II, Cl. n-PrO, Η), (M-3998, F, II, Cl, n-PrO, Cl), F, II, Cl, n-PrO, F), (M-4000, F, H, Cl, n-PrO, CFr〇, (M-^OOl, F, II, CA, n-PrO, Hr), (M-4002, F, H. Cl. n-PrO, CII.3), (M-4003, F, Π, Cl, PhO, II), (M-4004, F, II, Cl, Ph(), Cl). (Μ-400Γ), F? H, Cl, PhO, F), (M-400G, b\ if, Cl, l^hO, CF：0, (M.4007, F, II, Cl, PhO. Br), (M-4008, F, H, Cl, PhO, CII3), (M-d()0i), F, M, Cl, BnO, II), (M.4010, F. H, Cl, BnO, Cl), (M-4011, F, H, Cl, BnO, F), (M-4012, F, H, Cl, BnO, CF3), (M-4013. F. FL Cl, BnO, Br), (M-40H, F, H, Ci, BnO, CHn), (M-4015, K, II, Cl, PhCIhCIhO, Η), (M-4016, F, H, Cl, PhCJI2CH2〇> Cl), (M-4017, F, II, Cl, PhCH2CIl2〇. F), (M-4018, F, H, Cl, PhCFhCfhO, CKn), (M-4019, F, M, Cl, PhCH2CH2〇, Br), (M-4020, F, H, Cl, PhClhCIhO, CMa), (M.4021, F, II, Cl, CFaO, II), (M-4022, F, H, Cl, CF3〇, Cl), (M-4023, F, II, Cl, CFaO, F), (M-4024, F, II, Cl, CFaG, CF：〇, (M-4025, F, H, Cl, CF3O, Br), (M-4026, F, II, Cl, 〇Ι^(λ CHa), (M-4027, F, II, Cl, Ph? Η), (M-4028, F, H, Cl, Ph, Cl), (M-4029, F, II, Cl, Fh, F), (M-4030, F, H, Cl, Ph, CF3), (M-4031, F, H, Cl, Ph, Br), (M-4032, K, M, Cl, Ph, CH3), (M-4033, F, II, Cl. 4-F-Ph, FI), (M-4034, F, H, Cl, /l-K-Fh, Cl), (Μ-403Γ), F, II, Cl, 4-F-Ph, F). (Μ-403Γ3, F, H, Cl, 4-F-Ph, CFr〇, (M-4037, K, H, C\. /1-F-Ph, Hr), (M-4038, F. H, Cl. 4-F-Ph, CHa), (M-4039, F, H, Cl, 4.CFn-Ph, Μ), (Μ.Ί040, F, II, CL 4-CF3-Ph. Cl), (M-4041, F, II, Cl, 4-CF.vPh, F), (M-4042, K, II, Cl, 4.CKvPh, CFn). (M-4043 Ff H, Cl, 4-CF3-Ph, Br), (Μ-4ίΗ4, ΙΛ II, Cl, 4-CPm-IMi, CII3), (M-4045, F, II, Cl, 4-(Me)2N.ph, Η), (M-4046, F, II, Cl, 4-(Μο)2Ν-Ρ1ι, Cl), (M-4047, F. H. Cl, 4- 154 ____—-----41^ (請先閱讀背面之注意事項再填寫本頁) 訂—
I 1 ϋ I 參· 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 __B7_ 五、發明說明（W ) (Me)2N.[^h, F), (M-4048, F, II, Cl, 4-(Mo)2N-Ph, CF；〇, (Μ-404Π, F, H, Cl, 4-(Me)2N-Ph, Br), (M-4050, F, II, Cl, 4.(Mo)2N.Ph, CAL·), (M-4051, F, Ii, Cl, 4-OH-Ph, Μ), (M-4052, F, II, Cl, ^-OIMMi, (：!), (Μ-40Γ)；}, F, II, Cl, 4-OH-Ph. F). (M-4054, F, H, Cl, 4-OH-Ph, CPa), (M-4055, P, II, Cl, Ί-ΟΙΙ-ΡΗ, Br), (M-4056, F. H. (；], 4-011-1^, CIIm), (Μ^0Γ)7, K, II, Cl, II), (Μ-ΙΟΠΗ, l\ II, (M, 3.4-di-F.Ph, Cl), (M-4059, F, H, Cl, 3,4-di-F-Ph, F), (M-4060, F, H, CL 3,4-di-F-Ph, CFa), (M-4061, F, H, Cl, Hr), (M-4062, F, M, Cl, 3,4-cti-F.Ph, CH.3), (M-4063, Ff H, Cl, 4-COOiΙ-ΙΜι, II), K, H, Cl, /l-COOH-Ph, Cl), (M-4065, F, II, Cl, 4-COOII.Ph, F), (Μ.4()(Κ5, P, H, Cl, 4-0001 l-Ph. CF：〇, (M-4067, F, H, Cl, 4-COOH-Ph, Br), (M.4(K；8, F, II, Cl, ^-COOH-Ph, CHa), (M-40G9, F. H, Cl, Bn, Η), (M-4070, F, II, Cl, Hn, Cl), (M-4071, F, II, Cl, Bn, F), (M-4072, F. H. Cl, Bn, CF.3), (M-4073, F, II, Cl, Hn, Br), (M-4074, F, II, Cl, Bn, Clin), (M-4075, F, II, Cl, 4-F-Bn, H), (M./|〇7(5, II, Cl, 4-F-Bn, Cl), (M-4077, F, H, Cl. 4-F-Bn, F), (M-4078, F, II, Cl, d-F-Bn, CFr〇, (M.4079, F, H, Cl, 4-F-Bn. Br), (M-4080, F, II, Cl, 4-F-Bn, CUa), (M-4081, P, II, Cl, 2-Py, Π), (M-4082, F, II, Cl, 2- Py, Cl), (M-4083, F, H, Cl, 2-Py, (M-4084, F, II, Cl, 2-Py. (M-4085. F. IL Cl, 2-Fy, Br), (M-4086, F, II, Cl, 2-1^, CH；〇, (M-/l()87, F, II, Cl, 3-Py, Π), (M-4088, F, H, Cl, 3-Py, Cl), (M-^1089, F, II, Cl, 3-Py, F), (M-4090, F, II, Cl, 3-Py. CF.3), (M-4091, F, II, Cl, ：M}y, Hr), (Μ-40ί)2, F, II, Cl, H-Py, CHa), (M-4093, F; II, Cl, 4-Py, II), (Μ-40ί)^1, P, II, Cl, Ί-Py, Cl), (Μ-409Γ), F, II, Cl, 4-Py, F), (M-4096, F, II, Cl, 4-Py, CFn), (M-/10»7, F, II, (M, 4-Py, Hr), (M-4098. F. H. Cl, 4-Py. CII3), (M-4099, F, II, Cl, 2-Th, II), (M-4100, \<\ II, Cl, 2-Th, Cl). (M-4101, F, H? Cl, 2-Th, F), (M-4102, P, Π, Cl, 2-Th, (M-4103, F, II. Cl, 2-Th. Br), (M-4104, F, II, Cl, 2-Th, CII：〇, (M-4105, K, II, C|t ；}-Th, II), (M-410(>. F, IL Cl. 3- Th, Cl), (M-4107, F, II, Cl, ：}-Th, I〇, (M.4108, K, II, Cl, 3-Th, CPr〇, (M-4KH). F, H, Cl, 3-Th, Br), (M-4110, F, H, Cl, 3-Th, CH3), (M-4111, F, H, Cl,吡唑-2- 155 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ——-----411^ (請先閱讀背面之注意事項再填寫本頁) 訂---------線秦 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、發明說明（ (請先閱讀背面之注意事項再填寫本頁) 基，Η)，（1^·4112, F, H;C1,吡唑-2-基，(〕1)，（Μ·4113, F, H,(儿吡唑-2-基^)， (Μ·4ΐι4, f，fl, C1,壯嗤-2_碁，(〕叫，（Μ-4ΗΓ), l·，，Η, (〕|，吡唑-2-基，Br), (Μ·411(5, F, H, Cl,咐哗-2-基，（】iin)，（Μ·4117, l·，，II，（:1，吡唑-3-基、H)， (M-4118, F，H, C1，吡唑-3-棊，（】1)，（NM119, K, II，（〕1，吡嗤-3-基，1?)，（1^-化()，K, H，（;1,吡唑-3-基，(M-川丨，l·，，II, (Ί，吡唑·3·基，丨“ 4122, F，H, C1，吡嗤-3-基，Clh), (Μ·4123, F，1丨，C1,嘧啶·2·基，ii)，（M· 412U，H, Cl,嘧啶·2·基，（〕Ι)，（Μ-Ή2Γ)，Κ, 11，（:1，嘧啶·2·基 ^),(1^· 4126, F, H，ci,嘧啶·2-基 > (Μ-/Η27, F，Η· (Ί 嘧啶-2-基，Br), (Μ·4128, F, H，C1,喷陡-2-基，（;ΙΙ3)，（ΝΜ12», Κ. 嘧啶-4-基，11), 經 濟 部 智 慧 財 產 局 員 工 消 費 合 fi 製 (M_4l3〇, f, H, Cl,嘛症·4-基，（;丨)，（1VM1:U，K, 1丨，（】丨，嘧眭·4·基，F)， (Μ·4132, F, H, C1,喃疲·4·基，（〕Fn)，（Μ-4133, l·' H, C1，嘧啶-4-基，Br)， (Μ·4134, F, H，C1,哺症·4·基，CIh)，（M-4135，F, K，（〕l，嘧啶-5-基，II)， (Μ·4136, F, H, Cl,瞭陡-5·基，（〕1)，（M-4137, F，Η，（儿嘧啶-5-基，F)， (Μ·4138, F, H, Cl,嘧啶-5-基 * CF：〇, (Μ·Ί 13i), l·' H, Cl,贿陡· 5 -碁 j Rr)， (M-4140, f, h, Cl, ^ .5.¾ , CH；〇, (M-4HI, F, H, Cl, IIOOCCII2CH2CH2. Η), (M-4142, F, H, Cl, HOOCCII2CH2CH2, Cl), (M-4143, F, H, Cl, HOOCCH2CII2CH2, F), (M-414/1, F, H, Cl, IIOOCCII2CH2CII2, CFn), (M-4145, F, H. Cl, HOOCCH2CH2CH2, Br), (M-414G, l·1, II, Cl, UOOCCH2CM2CII2, CII3). (M-4147, F, H, Cl, HOOCCH2CM2CII2CH2, II), (M-4H8, ΙΛ M, Cl, HOOCCH2CH2CH2CII2, Cl), (M-4HJ), K, H, Cl, II()OCCll2CH2CH2CH2, F). (M-4150, F，H, Cl, HOOCCH2Cn2(〕il2(〕ll2, （Μ·41Γ)1, F，H，Cl， HOOCCH2CH2CH2CII2, Br), (M-4152, ΙΛ II, Cl, IIO()CCil2CH2CIIi>CH2. CII3). (M-4153, F，H, Cl, <Me)2NCOCH2CH2(〕H2(〕n2, H)，（Μ-41Γ)4, F, II，Cl, (Me)2NCOCH2CH2CH2CH2, Cl)，（ΜΜΙΓΑ，l·' 11，Cl，（MekNCOClhClhGlhClh， F), (M-4156, F, II, Cl, (Mo)2NC()Cll2Cil2(vlI2Cll2, CK：〇, (M-4157, F, H. cl (Me)2NC()ClI2CH2CH2CIl2, I3r)，（M-41/38, F，li，（〕1，（Me)2NC()CIhGH2CH2CH2. 156 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） A7 1284639 ___B7_：_ 五、發明說明（〆) (請先閱讀背面之注意事項再填寫本頁) CH3), (M-4159, F, H, Cl, (Me)2NCOCH2CH2CH2CH2CH2, H>, (M-4160, F, H，C1, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (Μ·4161, F, H, Cl, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-4162, F, H, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CFs), (M-4163, F, H, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-4164, F, II, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M.4165, F, H, Cl, MeOCH2, Η), (Μ·416β, F, H, Cl, MeOCH2, Cl), (Μ·4167, F, H, Cl, MeOCH2, F), (Μ·4168, F, H, Cl, MeOCH2, CF3), (M-4169, F, H, Cl, MeOCH2, Br), (Μ·4170, F, H, Cl, MeOCiI2, CH3), (Μ·4171, F, H, Cl, EtOCH2, Η), (M-4172, F, H, Cl, EtOCH2, Cl), (M-4173, F, H, Cl, EtOCH2, F), (M-4174, F, H, Cl, EtOCH2, CF3), (M-4175, F, H, Cl, EtOCH2, Br), (M-4176, P, H, Cl, EtOCH2, CHa), (M-4177, F, H, Cl, EtOCH2CH2, Η), (M-4178, F, H, Cl, EtOCH2CH2, Cl), (M-4179, F, H, Cl, EtOCH2CH2, F)， (M-4180, F, H, Cl, EtOCH2CH2, CF3), (M-4181, F, H, Cl, EtOCH2CH2, Br), (Μ·4182, F, H, Cl, EtOCH2CH2, CHa), (Μ·4183, F，H, Cl, MeOCH2CH2〇CH2CH2, Η), (M-4184, F, H, Cl, MeOCH2CH2OCH2CH2, Cl), (M-4185, F, H, Cl, MeOCH2CH2〇CH2CH2, F), (M-4186, F, H, Cl, MeOCH2CH2〇CH2CH2, CF3), (M-4187, F, H, Cl, MeOCH2CH2〇CH2CH2, Br), (M-4188, F, H, Cl, 經濟部智慧財產局員工消費合作社印製
MeOCH2CH2〇CH2CH2, CH3), (Μ·4189, F, H, Cl, MeOCH2CH2, Η), (M-4190, F， H, Cl, MeOCH2CH2, Cl), (M-4191, F，H, Cl, MeOCH2CH2, F), (M-4192, F, H，Cl， MeOCH2CH2, CF3), (M-4193, F, H, Cl, MeOCH2CH2, Br), (M-4194, F, H, Cl, MeOCH2CH2, CH3), (NT-4195, F, H, Cl, HOCH2, Η), (M-4196, F, H, Cl, HOCH2, Cl), (Μ·4197, F, H, Cl, HOCH2, F), (M-4198, F, H, Cl, HOCH2, CF3), (Μ·4199, F， H, Cl, HOCH2, Br), (M-4200, F, H, Cl, HOCH2, CH3), (Μ·4201, F, H, Cl, HOCH2CH2, Η), (M-4202, F, H, Cl, HOCH2CH2, Cl), (M-4203, F, H, Cl, HOCH2CH2, F), (M-4204, F, H, Ci, HOGII2CH2, CFa), (M-4205, F, H, Cl, HOCH2CH2, Br), (M-4206, F, H, Cl, HOCH2CH2, CHa), (M-4207, F, H, Cl, 167 i 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 __B7 ；__ 五、發明說明（、外） (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 HOCH2CH2CH2, Η), (Μ·4208, F, H, Cl, HOCH2CH2CHa，Cl), (M-4209, F, H, C1， HOCH2CH2CH2, F), (M-4210, F, H, Cl, HOCH2CH2CH2, CFa), (M-4211, F, H, Cl, HOCH2CH2CH2, Br), (M-4212, F, H, Cl, HOCH2CH2CH2, CHs), (M-4213, F, H, Cl, HOCH2CH2CH2CH2, Η), (M-4214, F, H, Cl, HOCH2CH2CH2CH2, Cl), (M-4215, F, H, Cl, HOCH2CH2CH2CII2, F), (M-4216, F, II, Cl, HOCIl2CIl2C!ll2Cll2, CFs), (M-4217, F, H, Cl, HOCH2CH2CH2CH2, Br), (M-4218, F, H, Cl, HOCH2CH2CH2CH2, CHa), (M-4219, F, H, Cl, HOCH2CH2CH2CH2CH2, H), (M-4220, F, H, Cl, HOCH2CH2CH2CH2CH2, Cl), (M-4221, F, H, Cl, HOCH2CH2CH2CH2CH2, F), (M-4222, F, H, Cl, HOCH2CH2CH2CH2CH2, CF3), (M-4223, F, H, Cl, HOCH2CH2CH2CH2CH2, Br), (M-4224, F, H, Cl, HOCH2CH2CH2CH2CH2, CH3), (M-4225, F, H, Cl, HOCH2CH2OCH2CH2, H), (M-4226, F, H, Cl, HOCH2CH2OCH2CH2, Cl), (M-4227, F, H, Cl, HOCH2CH2OCH2CH2, F), (M-4228, F, H, Cl, HOCH2CH2OCH2CH2, CFa), (M-4229, F, H, Cl, HOCH2CH2OCH2CH2, Br), (M-4230, F, H, Cl, HOCH2CH2OCH2CH2, CHs), (M-4231, F, H, Cl, (Me)2N, Η), (M-4232, F, H, Cl, (Me)2N, Cl), (M-4233, F, H, Cl, (Me)2N, F), (M-4234, F, H, Cl, (Me)2N，CF3), (M-4235, F, H, Cl, (Me)2N, Br), (M-4236, F, H, Cl, (Me)2N, CHa), (M-4237, F, H, Cl,哌啶-4 -基甲基，Η), (Μ·4238, F, H, Cl,祕啶-4 -基甲基，Cl>, (M-4239, F, H, Cl,哌啶-4·基甲基，F), (M-4240, F, H, Cl,哌啶-4一 基甲基，CF3), (M-4241, F, H, Cl,:哌啶 _ 4 -基甲基，Br), (M-4242, F，Η, Cl,哌啶·4-基甲基，CH3), (Μ·4243, F, Η, Cl,環己基甲基，Η), (Μ-4244, F, Η, Cl,環己基甲棊，Cl), (Μ·424δ, F, Η, Cl,環己基甲基，F), (Μ·4246, F, H, Cl,環己基甲基，CF3), (M-4247, F, H, Cl,·環己基甲基， Br), (Μ·4248, F, H, Cl,環己基甲基，0出)，（1^4249,?,?,]：1,1：^),(1^-4250, F, F, Η, H, Cl), (M.4251, F, F, Η, H, F>, (M-4252, F, F, Η, H，CF3), (M-4253, F, F, Η, Η, Br), (Μ·4254, F, F, Η, Η, CH3), (Μ·425δ, F, F, Η, F, Η), (Μ-4256, F, 158 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 五、發明說明（⑺） (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 F, H, F, Cl), (M-4257, F, F, H, F, F), (M-4258, F, F, H, F, CF3), (M-4259, F, F, H， F, Br), (Μ·4260, F, F, H, F, CH3>, (Μ·4261, F, F, H, Cl, Η), (M-4262, F, F, H, C1， C1), (Μ·4263, F, F, Η, Cl, F), (Μ·4264, F, F, Η, Cl, CFa), (Μ·4265, F，F，Η，C1， Br), (Μ·4266, F, F, Η, Cl, CH3), (Μ·4267, F, F, Η, CHa, Η), (Μ·4268, F, F, Η， CH3, Cl), (Μ-4269, F, F, Η, CH3, F), (Μ-4270, F, F, Η, CHa, CFa), (Μ-4271, F, F, Η, CH3, Br), (Μ-4272, F, F, Η, CH3, CH3), (Μ-4273, F, F, Η, Et, Η), (Μ·4274, F, F, Η, Et, Cl), (Μ-4275, F, F, Η, Et, F), (Μ-4276, F, F, Η, Et, CF3), (Μ-4277, F，F， Η, Et, Br), (Μ·4278, F, F, Η, Et, CH3), (Μ·4279, F, F，Η, n-Pr，Η)，（Μ-4280, F, F, Η, n-Pr, Cl), (Μ-4281, F, F, Η, n-Pr, F)，（Μ-4282, F, F, Η, n-Pr, CF3)，（Μ-4283, F, F, Η, n-Pr, Br), (Μ-4284, F, F, Η, n-Pr, CH3), (Μ-4285, F, F, Η, c-Pr, Η), (Μ·4286, F, F, Η, c-Pr, Cl), (Μ-4287, F, F, Η, c-Pr, F), (Μ-4288, F, F，Η，c-Pr, CFa)，（Μ-4289, F, F, Η, c-Pr, Br), (Μ-4290, F, F, Η, c-Pr, CH3), (Μ-4291，F, F, Η, i-Pr, Η), (Μ-4292, F, F, Η, i-Pr, C1), (Μ·4293, F, F, Η, i.Pr, F), (Μ-4294, F，F, Η, i-Pr, CFa), (Μ-4295, F, F, Η, i-Pr, Br), (Μ-4296, F, F, Η, i-Pr, CH3), (Μ-4297, F, F, Η, η·Βιι, Η), (Μ-4298, F, F, Η, n.Bu, Cl), (Μ·4299, F, F, Η, n-Bu, F)，（Μ-4300, F, F, Η, n-Bu, CF3), (Μ-4301, F, F, Η, n-Bu, Br), (Μ-4302, F, F, Η, n-Bu, CHa), (Μ·4303, F, F, Η, i-Bu, Η), (Μ·4304, F, F, Η, i-Bu, Cl), (Μ-4305, F, F, Η, i-Bu， F), (Μ·4306, F, F, H, i-Bu, CF3), (Μ·4307, F, F, H, i-Bu, Br), (M-4308, F，F, H, i-Bu, CHa), (M-4309, F, F, H, sec-Bu, Η), (M-4310, F, F, H, sec-Bu, Cl), (M-4311, F, F, H, eec-Bu, F), (M-4312, F, F, H, sec-Bu, CFa), (M-4313, F, F, H, sec-Bu, Br), (M-4314, F, F, H, sec-Bu, CHa), (M-4315, F, F, H, n-Pen, Η), (M-4316, F, F, H, n-Pen，Cl), (M-4317, F, F, H, n-Pen, F), (M-4318, F, F，H, n-Pen, CFs)，（M-4319, F, F, H, n-Pen, Br), (M-4320, F, F, H, n-Pen, CHa), (M-4321, F, F, H, c-Pen. H), (M-4322, F, F, H, c-Pen, Cl), (M-4323, F, F, H, c-Pen, F), (M-4324, F, F, H, c-Pen, CF3), (M-4325, F, F, H, c-Pen, Br), (Μ·4326, F, F, H, c-Pen, CH3), (M-4327, F, F, H, n-Hex, Η), (M-4328, F, F, H, n-Hex, Cl), (M-4329, F, F, H, n-Hex, F), 169 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 經 濟 部 智 慧 財 產 局 員 工 消 費 合 作 社 印 製 A7 B7 五、發明說明（W) (M-4330, F, F, H, n-Hex, CFs), (M-4331, F, F, H, n-Hex, Br), (M-4332, F, F, H, n-Hex, CH3), (M-4333, F, F, H, c-Hex, Η), (M-4334, F, F, H, c-Hex, Cl), (M-4335, F, F, H, c-Hex, F), (M-4336, F, F, H, c-Hex, CFa), (M-4337, F, F, H, c-Hex, Br)， (M-4338, F, F, H, c-Hex, CH3), (M-4339, F, F，H, OH, Η), (Μ·4340, F，F, H, OH, Cl), (M-4341, F, F, H, OH, F), (M-4342, F, F, H, OH, CFs), (M-4343, F, F, II, Oil, Br), (M-4344, F, F, H, OH, CHs), (M-4345, F, F, H, EtO, Η), (M-4346, F, F, H, EtO, Cl), (M-4347, F, F, H, EtO, F), (M-4348, F, F, H, EtO, CFa), (M-4349, F, F, H, EtO, Br), (M-4350, F, F, H, EtO, CH3), (M-4351, F, F, H, n-PrO, Η), (M-4352, F, F, H, n-PrO, Cl), (M-4353, F, F, H, n-PrO, F), (Μ·43δ4, F, F, H, n-PrO, CF3), (M-4355, F, F, H, n-PrO, Br), (M-4356, F, F, H, n-PrO, CH3), (M-4357, F, F, H, PhO, Η), (M-4358, F, F, H, PhO, Cl), (M-4359, F, F, H, PhO, F), (M-4360, F, F, H, PhO, CF3), (M-4361, F, F, H, PhO, Br), (Μ·4362, F, F, H, PhO, CH3), (M-4363, F,F,H,BnO,H),(M-4364,F,F,H,BnO,Cl),(M-4365,F,F,H,BnO,F),(M-4366, F, F, H, BnO, CF3), (Μ·4367, F, F, H, BnO, Br), (M-4368, F, F, H, BnO, CH3), (M-4369, F, F, H, PhCH2CH2〇, H>, (M-4370, F, F, H, PhCH2CH20, Cl), (M-4371,F,F,H,PhCH2CH2〇,F),(M-4372,F,F,H,PhCH2CH2〇,CF3),(M· 4373, F, F, H, PI1CH2CH2O, Br), (Μ·4374, F, F, H, PhCH2CH2〇, CH3), (M-4375, F, F, H, CF3〇, Η), (M-4376, F, F, H, CF3〇, Cl>, (Μ·4377, F, F，H, CF3〇, F), (M-4378, F, F, H, CF3〇, CF3), (M-4379, F, F, H, CFaO, Br), (M-4380, F, F, H， CFsO, CHa), (M-4381, F, F, H, Ph, Η), (M-4382, F, F, H, Ph, Cl), (M-4383, F, F, H, Ph, F), (M-4384, F, F, H, Ph, CFs), (M-4385, F, F, H, Ph, Br), (M-4386, F, F, H, Ph, CHa), (M-4387, F, F, H, 4-F-Ph, H), (M-4388, F, F, H, 4-F-Ph, Cl), (M-4389, F, F, H, 4-F-Ph, F), (M-4390, F, F, H, 4-F-Ph, CFa), (M-4391, F, F, H. 4-F-Ph, Br), (M-4392, F, F, H, 4-F-Ph, CHa), (M-4393, F, F, H, d-CFa-Ph, H), (M-4394, F, F, H, 4-CF3-Ph, Cl), (M-4395, F, F, H, 4-CF3-Ph，F), (M-4396, F，F, H, 4.CF3.Ph, CF3), (M-4397, F, F, H, 4.CFa-Ph, Br), (M-4398, F, F, H, 4-CF3-Ph, 160 本紙張尺度適用中國國家標準（CNS)A4規格（21〇 x 297公釐）
» 一 --------1--------- (請先閱讀背面之注咅？事項再填寫本頁) 1284639 A7 B7 五、發明說明（奶） CII3), (M-4399, F, F, H, 4-(Mo)2N.[,h, II), P, F, H, 4-(Mo)2N-Ph. Cl). (M-4401, F, F, 11，4-(Me)2N-Ph，F)，（Μ·Κ()2, l·' l·' II，4-(Μ(，）2Ν-Πι. （Μ· (請先閱讀背面之注意事項再填寫本頁) 4403, F, F, H, 4-(Me)2N-Ph, Br), (M-4404, F, F, H, 4-(Me)2N.Ph, Clin), (M-4405. F, F, H, 4-OH-Ph, Η), (M-4406, F, F, H, 4-OH-Ph, Cl), (M-4407, F, F, H, 4-OH-Ph, F), (M-4408, F, F, H, /1-OlI-IMi, CK：〇, (Μ-Ή09, K, K, II, Ί-ΟΠ-Πι, Hr), (M-4410, F，F, H, 4-OH-Ph，Cih), (M-4411, F，F, U，li), (M-以 12, F, F, H, 3,4-di.F-Ph, Cl), (M-4413, F, F, II, 3,4-di-F.Ph, F), (M-4414, F, F, H. 3,4-di-F.Ph, CF3), (M-4415, F, F, M, Br), (M-4416, F. F, II, 3.4.(li- 經濟部智慧財產局員工消費合作社印製 F-Ph, CHs), (M-4417, F, F, II, d-COOM-Ph, H), (M-4418, F, F, H, 4-COOH-Ph, Cl), (M-4419, F, F, H, 4.COOH-PI1, F), (M-4420, F, F, H, 4.COOJI-Ph, CFa), (M-4421, F, F, H, 4-COOH-Ph, Br), (M-4422, F, F, H, 4-COOH-Ph, CH3), (M-4423, F, F, Η, Bn, Η), (M-4424, F, F, II, Bn, Cl), (M-4425, F, F, II, Bn, F), (M-4426, F, F, H, Bn, CF3), (M-4427, F, F, H, Hn, Hr), (M-4428, F, F, H, Bn, CH；〇. (M-4429, F, F, H, 4-F-Bn, Η), (M-4430, F, F, H, 4-F-Bn, Cl), (M-4431, F, F, H. 4-F-Bn, F), (M-4432, F, F, II，4·Ρ’·Βη, CFa), (M-4433, F, F, II，4-F-Bn，Br). (M-4434, F, F, H, 4-F-Bn, CII3), (M-4435, F, F, II, 2-Py, II), (M-443G, F, F, II, 2-Py, Cl), (M-4437, F, F, H, 2-Py, F), (M.4438, F, F, II, 2-Py, CF3), (M-4439, F. F. H. 2-Py, Br), (M-4440, F, F, H, 2-Py, CH,〇, (Μ·άΛΛΙ, F, F, II, 3-Py, Η), (M-4442, F, F, II, 3-Py, Cl), (M-4443, F, F, II, 3-Py, F), (M-4444, P, F, 11, 3-Py, CF：〇, (M-4445, F, F, H, 3-Py, Br), (M-4446, F, F, II, 3-Py, Clin), (M-4447, F, F, II, 4-Py, II), (M-4448, F, F, H, 4-Py, Cl), (M-4449, F, F, II, 4-Py, F), (M-4450, F, F, II, 4-Py, CFa), (M-4451, F, F, H, 4-Py, Br), (M-4452, F, F, H, 4-Py, CH：〇. (M-4453. F, F. H, 2-Th, Η), (M-4454, F, F, H, 2-Th, Cl), (M-4455, F, F, II, 2-Th, F). (M-4456. F. F, II, 2-Th, CF3), (M-4457, F, F, II, 2-Th, Hr), (M-^58, F, F. II. 2-Th, CAL·), (M-4459, F, F, H, 3-Th, II), (M-44G(), F, F, II, 3-Th, Cl), (M-4461. F, F, H. 3-Th, F), (M-4462, F, F, H, 3-Th, CF：〇, (M-44G3, F, F, II, 3-Th, Hr), (M-44G4, F. F. H. 161 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7_ \__ 五、發明說明（‘） 3-Th, CH3), (M-4465, F, F, Η,吡唑-2-棊，Η), (M-4466, F, F，Η,吡哗-2· (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 基 Cl), (Μ·4467, F, F, Η,吡唑-2 -碁 F), (Μ-4468, F, F, Η,吡唑-2 -基:,CF3), (M-4469, F, F, Η,吡唑-2-基；Br), (M-4470, F, F, Η,吡唑-2-基，CH3), (M-4471, F, F, H,吡唑-2 -棊:,丑)，（]^4472,?,卩，11,;吡唑，3-基，（：1),(1^-4473, F, F, Η,吡唑-3 -基，F), (Μ·4474, F, F, Η,吡唑-3 -碁，CF3), (Μ·4475, F, F, Η,吡唑-3 -基，Br), (Μ-4476, F, F, Η,吡唑-3 基，CH3), (Μ·4477, F，F， H,艰啶-2-基，Η), (M-4478, F, F, H,喃啶-2-基，Cl), (M-4479, F, F, Η, 嘧啶-2·基，F), (M-4480, F, F, H,嘧啶-2-基，CF3), (M-4481, F, F, H， 嘧啶乂2-基，Br), (M-4482, F, F, H,嘧啶-2-基，CH3), (M‘4483, F, F, II, 嘧啶·4·基，Η), (M-4484, F, F, H,嘧啶-4-基，Cl), (M-4485, F, F, H, 嘧啶-4-基，F), (M-4486, F, F, H,嘧啶-4-基,CF3>, (M-4487, F, F, H, 嘧啶-4-基，Br), (M-4488, F, F, H,嘧啶-4-基,CH3), (Μ·4489, F, F, H, 嘧啶-5-基，Η), (M.4490, F, F, H,嘧啶-5-基，Cl), (M-4491, F，F, H, 嘧啶-5·基，F), (M-4492, F, F, H,嘧啶-5-基，CF3), (M-4493, F, F, H, 液啶-5·基· Br), (M-4494, F, F, H,嘧啶·5·基，CH3), (M-4495, F, F，H， HOOCCH2CH2CH2, Η), (M-4496, F, F, H, HOOCCH2CH2CH2, Cl), (M-4497, F, F, H, HOOCCH2CH2CH2, F), (M-4498, F, F, H, HOOCCH2CH2CH2, CFa), (M-4499, F, F, H, HOOCCH2CH2CH2, Br), (M-4500, F, F, H, HOOCCH2CH2CH2, CHa), (M-4501, F, F, H, HOOCCH2CH2CH2CH2, Η), (M-4502, F, F, H, HOOCCH2CH2CH2CH2, Cl), (M-4503, F, F, H, HOOCCH2CH2CH2CH2, F), (M· 4504, F, F, H, HOOCCH2CH2CH2CH2, CFa), (M-4505, F, F, H, HOOCCH2CH2CH2CH2, Br), (M-4506, F, F, H, HOOCCH2CH2CH2CH2, CHa), (M-4507, F, F, H, (Me)2NCOCH2CH2CH2CH2, Η), (M-4508, F, F, H, (Me)2NCOCH2CH2CH2CH2, Cl), (M-4509, F, F, H, (Me)2NCOCH2CH2CH2CH2， F), (M-4510, F, F, H, (Me)2NCOCH2CH2CH2CH2, CF3), (M-4511, F, F, H, (Me)2NCOCH2CH2CH2CH2, Br), (M-4512, F, F，H, (Me)2NCOCH2CH2CH2CH2, 162 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 經濟部智慧財產局員工消費合作社印製 A7 __B7_：___ 五、發明說明) CH3f, (M-4513,V, F, H, (Me)2NCOCH2CH2CH2CH2CH2, Η), (Μ·4δ14, F, F，H， (Me)2NCOCH2CH2CH2CH2CH2, Cl), (Μ-4515, F, F, Η, (Me)2NCOCH2CH2CH2CH2CH2, F), (Μ-4616, F, F, Η, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (Μ-4517, F, F，Η, (Me)2NCOCH2CH2CH2CH2CH2, Br), (Μ-4518, F, F, Η, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (Μ-4519, F, F, Η, MeOCH2, Η)，（Μ·4520, F, F, Η, MeOCHs, Cl), (Μ-4521, F, F, Η, MeOCH2, F), (Μ-4522, F, F, Η， MeOCH2, CF3), (Μ-4523, F, F, Η, MeOCH2, Br), (Μ-4524, F, F, Η, MeOCH2， CH3), (Μ-4525, F, F, Η, EtOCH2, Η), (Μ-4526, F，F, Η, EtOCH2, Cl>, (Μ-4527, F， F, Η, EtOCH2, F), (Μ-4528, F, F, Η, EtOCH2, CF3), (Μ-4529, F, F, Η，EtOCH2, Br),(M-4530,F,F,H,EtOCH2,CH3),(M-4531,F,F,H,EtOCH2CH2,H),(M· 4532, F, F, Η, EtOCH2CH2, Cl), (Μ-4533, F, F, Η, EtOCH2CH2, F), (Μ-4534, F, F, H, EtOCH2CH2, CF3), (M-4535, F, F, H, EtOCH2CH2, Br), (M-4536, F, F, H, EtOCH2CH2, CHa), (M-4537, F, F, H, MeOCH2CH2〇CH2CH2, H)，（M-4538, F, F， H, MeOCH2CH2〇CH2CH2, Cl), (M-4539, F, F, H, MeOCH2CH2〇CH2CH2, F), (M-4540, F, F, H, MeOCH2CH2〇CH2CH2, CF3), (M-4541, F, F，H, MeOCH2CH2〇CH2CH2, Br), (M-4542, F, F, H, MeOCH2CH2〇CH2CH2, CH3), (M-4543,F,F,H,MeOCH2CH2，H),(M-4544,F,F,H,MeOCH2CH2,Cl),(M-4545, F, F, H, MeOCH2CH2, F), (M-4546, F, F, H, MeOCH2CH2, CF3), (M-4547, F, F, H，MeOCH2CH2, Br), (M-4548, F, F, H, MeOCH2CH2, CH3), (M-4549, F, F, H, HOCH2, Η), (M-4550, F, F, H, HOCH2, Cl), (M-4551, F, F, H, HOCH2, F), (M-4552, F, F, H, HOCH2, CF3), (M-4553, F, F, H, HOCH2, Br), (M-4554, F，F, H， HOCH2, CHs), (M-4555, F, F, H, HOCH2CH2, Η), (M-4566, F, F, H, HOCH2CH2, Cl), (M-4557, F, F, H, HOCH2CH2, F), (M-4558, F, F, H, HOCH2CH2, CFs), (M-4559, F, F, H, HOCH2CH2, Br), (M-4560, F, F, H, HOCH2CH2, CHa), (M-4561, F, F, H, HOCH2CH2CH2, Η), (M-4562, F, F, H, HOCH2CH2CH2, Cl), (M- 163 ^^尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） __：—^-------------^--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（知） 4563, F, F, H, HOCH2CH2CH2, F), (M-4564, F, F, H, HOCH2CH2CH2, CFa), (M-4565, F, F, H, HOCH2CH2CH2, Br), (M-4566, F, F, H, HOCH2CH2CH2, CH3), (M-4567, F, F, H, HOCH2CH2CH2CH2, Η), (M-4568, F, F, H, HOCH2CH2CH2CH2, Cl), (M-4569, F, F, H, HOCH2CH2CH2CH2, F), (M-4570, F, F, H, HOCH2CH2CH2CH2, CF3), (M-4571, F, F, H, HOCH2CH2CH2CH2, Br), (M-4572, F, F, H, HOGH2CH2CH2CH2, CHa), (M-4573, F, F, H, HOCH2CH2CH2CH2CH2, Η), (M-4574, F, F, H, HOCH2CH2CH2CH2CH2, Cl), (M-4575, F, F, H, HOCH2CH2CH2CH2CH2, F), (M-4576, F, F, H, HOCH2CH2CH2CH2CH2, CFa), (M-4577, F, F, H, HOCH2CH2CH2CH2CH2, Br), (M-4578, F, F, H, HOCH2CH2CH2CH2CH2, CHa), (M-4579, F, F, H, HOCH2CH2〇CH2CH2, Η), (M-4580, F, F, H, HOCH2CH2〇CH2CH2, Cl), (M-4581， F, F, H, HOCH2CH2OCH2CH2, F), (M-4582, F, F, H, HOCH2CH2OCH2CH2, CFa), (M-4583, F, F, H, HOCH2CH2OCH2CH2, Br), (M-4584, F, F, H, HOCH2CH2OCH2CH2, CHa), (M-4585, F, F, Η, (Me)2N, Η), (M-4586, F, F, H, (Me)2N, Cl), (M-4587, F, F, H, (Me)2N, F), (M-4588, F, F, H, (Me)2N, CF3), (M-4589, F, F, H, (Me)2N, Br), (M-4590, F, F, H, (Me)2N, CH3), (Μ·4591, F, F, H， 哌啶-4-基甲基.，Η), (M-4592, F, F, H,哌啶-4-基甲基.，Cl>，（M-4593, F, F, H,哌啶· 4 -基甲基，F), (M-4594, F, F, H,哌啶· 4 -基 甲基，CF3), (M-4595, F, F, H,哌啶 4 -基甲基.，Br), (M-4696, F, F, Η, 哌啶-4-基甲基，CH3), (M-4597, F, F, H,環己基甲基，Η), (Μ·4598, F, F, H,環己基甲基，Cl), (M-4599, F, F, H,環己基甲基，F), (Μ·4600, F, F, H,環己基甲基，CF3), (M-4601, F, F, H,環己基甲基，Br), (Μ-4602, F, F, H,環己基甲基,CH3), (M-4603, F, F, F, Η, H), (M-4604, F, F，F, H, Cl), (M-4605, F, F, F, H, F), (M-4606, F, F, F, H, CF3), (M-4607, F, F, F，H, Br), (M-4608, F, F, F, H, CH3), (M-4609, F, F, F, F, Η), (M-4610, F，F, F，F，Cl)， (M-4611, F, F, F, F, F), (M-4612, F, F, F, F, CF3), (M-4613, F, F, F, F，Br), 164 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --·-----------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 a7 B7 五、發明說明（ιθ) (M-4614, F, F, F, F, CH3), (M-4615, F, F, F, Cl, Η), (Μ·4616, F, F, F, Cl，Cl), (Μ-4617, F, F, F, Cl, F), (Μ-4618, F, F, F, Cl, CF3), (Μ-4619, F, F，F, Cl, Br), (M-4620, F, F, F, Cl, CH3), (M-4621, F, F, F，CH3, Η), (M-4622, F, F, F, CH3, Cl), (M-4623, F, F, F, CH3, F), (M-4624, F, F, F, CH3, CF3)，（Μ·4625, F, F· F. CHi Br), (M-4626, F, F, F, CH3, CH3), (M-4627, F, F, F, Et, Η), (M-4628, F, F, F，Et, Cl), (M-4629, F, F, F, Et, F), (M-4630, F, F, F, Et, CF3), (M-4631, F, F, F, Et, Br)， (M-4632, F, F, F, Et, CH3), (M-4633, F, F, F, n-Pr, Η), (M-4634, F, F, F, n-Pr，Cl), (M-4635, F, F, F, n-Pr, F), (M-4636, F, F, F, n-Pr, CF3)，（M-4637, F, F, F，n-Pr， Br), (M-4638, F, F, F, n-Pr, CH3), (M-4639, F, F, F, c-Pr, Η), (M-4640, F, F，F， c-Pr, Cl), (M-4641, F, F，F, c-Pr, F), (M-4642, F, F, F, c-Pr, CF3), (M-4643, F, F, F, c-Pr, Br), (Μ·4644, F, F, F, c-Pr, CH3), (M-4645, F, F, F, i-Pr, Η), (M-4646, F， F，F, i-Pr, Cl), (M-4647, F, F, F，i-Pr, F), (M-4648, F, F，F, i-Pr, CF3)，（M-4649, F,F,F,i-Pr,Br),(M-4650,F,F,F,i-Pr,CH3),(M-4651,F,F,F,n-Bu,H)，（M-4652, F, F, F, n-Bu, Cl), (M-4653, F, F, F, n-Bu, F), (M-4654, F, F, F, n-Bu，CF3)， (M-4655,F,F,F,n-Bu,Br),(M-4656,F,F,F,n-Bu,CH3),(M-4657,F，F,F，i· Bu, Η), (M-4658, F, F, F, i-Bu, Cl), (M-4659, F, F, F, i-Bu, F), (M-4660, F, F, F, i-Bu, CF3), (M-4661, F, F, F, i-Bu, Br), (M-4662, F, F, F, i-Bu, CH3), (M-4663, F, F, F, sec-Bu, Η), (M-4664, F, F, F, sec-Bu, Cl), (M-4665, F, F, F, sec-Bu, F), (M-4666, F, F, F, sec-Bu，CF3)，（M-4667, F, F, F, sec-Bu, Br), (M-4668, F, F，F, sec-Bu, CH3), (M-4669, F, F, F, n-Pen, Η), (M-4670, F, F, F，n-Pen, Cl)，（M-4671， F, F, F, n-Pen, F), (M-4672, F, F, F, n-Pen, CF3), (M-4673, F, F, F，n-Pen，Br)， (M-4674, F, F, F, n-Pen, CH3)，（M-4675, F, F, F, c-Pen, Η), (M-4676, F, F，F, c-Pen, Cl), (M-4677, F, F, F, c-Pen, F), (M-4678, F, F, F, c-Pen, CF3)，（M-4679, F, F, F, c-Pen, Br), (M-4680, F, F, F, oPen, CH3), (M-4681, F, F, F, n-Hex，H), (M-4682,F,F,F,n-Hex,Cl),(M-4683,F,F,F,n-Hex,F),(M-4684,F,F，F,n· Hex, CF3), (M-4685, F, F, F, n-Hex, Br), (M-4686, F, F, F, n-Hex, CH3), (M-4687, 165 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ' "" --.-----^------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 0-4688 ,F, F, F, c-Hex, Cl), (Μ·4689, F, F, F, c-Hex, F)， (M-4690, F, F, F, c-Hex, CFa), (M-4691, F, F, F, c-Hex, Br), (M-4692, F, F, F, c-Hex, CH3), (M-4693, F, F, F, OH, Η), (M-4694, F, F, F, OH, Cl), (M-4695, F, F, F, OH, F), (M-4696, F, F, F, OH, CF3), (M-4697, F, F, F, OH, Br), (M-4698, F，F, F, OH, CHa), (M-4699, F, F, F, EtO, Η), (M-4700, F, F, F, EtO, Cl), (M-4701, F, F, F, EtO, F)，（M-4702, F, F, F, EtO, CF3), (M-4703, F, F, F, EtO, Br), (M-4704, F, F，F，EtO, CH3), (M-4705, F, F, F, n-PrO, Η), (M-4706, F, F, F, n-PrO, Cl)， (M-4707, F，F, F, n-PrO, F), (M-4708, F, F，F, n-PrO, CF3), (M-4709, F, F，F， n-PrO, Br), (M-4710, F, F, F, n-PrO, CH3), (M-4711, F, F, F, PhO, Η), (M-4712, F,F,F,PhO,Cl),(M-4713,F,F,F,PhO,F),(M-4714,F,F,F,PhO,CF3),(M· 4715, F, F, F, PhO, Br), (M-4716, F, F, F, PhO, CH3), (M-4717, F, F, F, BnO, H)， (M-4718, F, F, F, BnO, Cl), (M-4719, F, F, F, BnO, F), (M-4720, F, F, F, BnO， CF3), (M-4721, F, F, F, BnO, Br), (M-4722, F, F, F, BnO, CHa), (M-4723, F, F, F, PhCH2CH2〇, Η), (M-4724, F, F, F, PhCH2CH2〇, Cl), (M-4725, F, F, F, PhCH2CH2〇, F), (M-4726, F, F, F, PhCH2CH2〇, CF3), (M-4727, F, F, F, PhCH2CH2〇, Br), (M-4728, F, F, F, PhCH2CH2〇, CH3), (M-4729, F, F, F, CF3〇, Η), (M-4730, F, F, F, CF3〇, Cl), (M-4731, F, F, F, CF3〇, F), (M-4732, F, F, F， CF30, CF3), (M-4733, F, F, F, CF3O, Br), (M-4734, F, F, F, CF3O, CH3), (M-4735, F, F, F, Ph, Η), (M-4736, F, F, F, Ph, Cl), (M-4737, F, F, F，Ph，F), (M-4738, F， F, F，Ph, CF3), (M-4739, F, F, F, Ph, Br), (M-4740, F, F, F, Ph，CH3), (M-4741，F， F, F, 4-F-Ph, H), (M-4f42, F，F, F, 4-F-Ph, Cl), (M-4743, F, F, F, 4-F-Ph, F)， (M-4744, F, F, F,4-F-Ph, CF3), (M-4745, F, F, F, 4-F-Ph, Br), (M-4746, F，F, F， 4-F-Ph, CH3), (M-4747, F, F, F, 4-CF3-Ph, Η), (M-4748, F, F, F, 4-CF3-Ph, Cl)， (M-4749, F, F, F, 4-CF3-Ph, F), (M-4750, F, F, F, 4-CF3-Ph，CF3)，（M-4751，F，F, F,4-CF3-Ph,Br),(M-4752,F，F,F,4-CF3-Ph,CH3),(M-4753,F,F,F，4-(Me)2N-Ph, Η), (M-4754, F, F, F, 4-(Me)2N-Ph, Cl), (M-4755, F，F，F, 4· 166 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） __·----：-------------^--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7
、 t kT ^ (λΐ^ϊΙ-ρΙ^^Μ^^δβ, F, F, F, 4-(Me)2N.Ph, CF3), (M-4757, F, F, F, 4- (Me)2N-Ph, Br), (M-4758, F, F, F, 4-(Me)2N-Ph, CHa), (M-4759, F, F, F, 4-OH-Ph, Η), (M-4760, F, F, F, 4-OH-Ph, Cl), (M-4761, F, F, F, 4-OH-Ph, F), (Μ·4762, F, F, F, 4-OH-Ph, CFs), (M-4763, F, F, F, 4-OH-Ph, Br), (M-4764, F, F, F, 4-OH-Ph, CHa), (M-4765, F, F, F, 3,4-di-F-Ph, Η), (M-4766, F, F, F, 3,4-di-F-Ph, Cl)，（M-4767,F,F,F,3,4-di-F-Ph,F),(M-4768,F,F,F,3,4-di-F-Ph,CF3),(M-4769, F, F, F, 3,4-di-F-Ph, Br), (M-4770, F, F, F, 3,4-di-F-Ph, CH3), (M-4771, F， F,F,4-COOH-Ph,H),(M-4772,F,F,F,4-COOH-Ph,Cl)，（M-4773，F,F，F，4· COOH-Ph, F), (M-4774, F, F, F, 4-COOH-Ph, CF3), (M-4775, F, F, F, 4-COOH-Ph, Br), (M-4776, F, F, F, 4-COOH-Ph, CH3), (M-4777, F, F, F, Bn, H)，（M-4778, F, F, F, Bn, Cl), (M-4779, F, F, F, Bn, F), (M-4780, F, F, F, Bn, CF3), (M-4781, F, F, F, Bn, Br), (M-4782, F, F, F, Bn, CH3), (M_4783, F, F, F, 4-F-Bn, Η), (Μ·4784, F, F, F, 4-F-Bn, Cl), (M-4785, F, F, F, 4-F-Bn, F), (M-4786, F, F, F, 4-F-Bii，CFa)， (M-4787, F, F, F, 4-F-Bn, Br), (M-4788, F, F, F, 4-F-Bn, CH3)，（M-4789, F, F, F, 2-Py, Η), (M-4790, F, F, F, 2-Py, Cl), (M-4791, F, F, F, 2-Py, F), (M-4792, F, F， F, 2-Py, CF3), (M-4793, F, F, F, 2-Py, Br), (M-4794, F，F, F, 2-Py, CHs), (M-4795, F，F, F, 3-Py, Η), (M-4796, F, F, F, 3-Py, Cl), (M-4797, F, F, F, 3-Py, F)，（M-4798, F, F, F, 3-Py, CF3), (M-4799, F, F, F, 3-Py, Br), (M-4800, F, F, F, 3-Py, CH3)， (M-4801，F, F, F, 4-Py, Η), (M-4802, F, F, F, 4-Py, Cl), (M-4803, F, F, F, 4-Py, F)， (M-4804, F, F, F, 4-Py, CF3), (M-4805, F, F, F, 4-Py, Br), (Μ·4806, F, F, F, 4-Py， CH3), (M-4807, F, F, F/2-Th, Η), (M-4808, F, F, F, 2-Th, Cl), (M-4809, F, F, F, 2-Th, F), (M-4810, F, F, F, 2-Th, CF3), (M，4811, F, F, F, 2-Th, Br), (M-4812, F, F, F, 2-Th, CHa), (M-4813, F, F, F, 3-Th, Η), (M-4814, F, F, F, 3-Th, Cl), (M-4815, F, F, F, 3-Th, F), (M-4816, F, F, F, 3-Th, CF3), (M-4817, F, F, F, 3-Th, Br)， (M-4818, F, F, F, 3-Th, CH3), (M-4819, F, F, F,吡唑-2·基，Η), (M-4820, F, F， F,吡唑-2-基，Cl), (M-4821, F, F, F,吡唑-2-基.，F), (M-4822, F, F，F， 167 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） (請先閱讀背面之注意事項再填寫本頁)
1284639 A7 B7 五 1^¾¾k), ()M·4823, F, F, F,壯嗤小基，Br), (M-4824, F, F，F， 吡唑-2-基，CH3), (M-4825, F, F, F,壯哗-3-棊，H)，（M-4826, F，F，F， 吡唑-3-基，C1), (M·4827, F, F, F,壯嗤-3·基· F)，（M·4828, F，F，F， (請先閱讀背面之注意事項再填寫本頁) 吡唑-3-基· CF3), (M-4829, F, F，F,吡唑·3·基，Br), (M-4830, F，F，F, 纸唑-3-基· CH3), (Μ·4831, F, F, F,嘧啶-2·基，Η), (M-4832, F, F, F,
I 經濟部智慧財產局員工消費合作社印製 味症-2-基，Cl), (Μ·4833, F, F, F,喃啶-2-基，F), (M-4834, F, F, F, 味啶·2·基，CF3), (M-4835, F, F, F,4H^-2-X，Br),(M-4836，F,F,F， 嘧啶·2·基，CH3), (M-4837, F, F, F,喃陡-4-基，Η), (M-4838, F, F，F， 嘧啶 _4-基，Cl)，（M-4839, F, F, F,嘧啶-4-基，F), (M-4840, F, F，F, 瞭啶·4·基，CF3), (M-4841, F, F, F,嘧啶·4-基，Br)，（M-4842, F, F, F， 嘧啶-4-基，CH3), (M-4843, F, F, F,嘧啶-5-基，Η), (M-4844, F, F, F， 咳症-5-基，Cl), (M-4845, F, F, F,嘧啶-5·基，F), (M-4846, F，F，F， 嘧啶-5-基，,CF3), (M-4847, F, F, F,嘧啶-5-基，Br), (NM848, F, F, F\ 嘧啶-5 ·基· CH3), (M-4849, F, F, F, HOOCCH2CH2CH2, Η), (M-4850, F, F, F, HOOCCH2CH2CH2, Cl), (M-4851, F, F, F, HOOCCH2CH2CH2, F), (M-4852, F, F, F, HOOCCH2CH2CH2, CF3), (M-4853, F, F, F, HOOCCH2CH2CH2, Br), (M-4854, F, F, F, HOOCCH2CH2CH2, CHa), (M-4855, F, F, F, HOOCCH2CH2CH2CH2, H), (M-4856, F, F, F, HOOCCH2CH2CH2CH2, Cl), (M-4857, F, F, F, HOOCCH2CH2CH2CH2, F), (M-4858, F, F, F, HOOCCH2CH2CH2CH2, CFa), (M-4859, F, F, F, HOOCCH2CH2CH2CH2, Br), (M-4860, F, F, F, HOOCCH2CH2CH2CH2, CHs), (M-4861, F, F, F, (Me)2NCOCH2CH2CH2CH2, H), (M-4862, F, F, F, (Me)2NCOCH2CH2CH2CH2, Cl), (M-4863, F，F，F， (Me)2NCOCH2CH2CH2CH2, F), (M-4864, F, F, F, (Me)2NCOCH2CH2CH2CH2， CF3), (M-4865, F, F, F, (Me)2NCOCH2CH2CH2CH2, Br), (M-4866, F, F，F， (Me)2NCOCH2CH2CH2CH2, CHs), (M-4867, F, F, F, (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-4868, F, F, F, 168 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 _ B7_ ：_ 五、發明說明（你） (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-4869, F, F, F, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-4870, F, F, F, (Me)2NCOCH2CH2CH2CH2CH2, CF3>, (M-4871, F, F，F, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-4872, F，F, F, (Me)2NCOCH2CH2CH2CH2CH2, CHs), (M-4873, F, F, F, Me〇Cll2, 11), (M-4874, F, F, F, MeOCH2, Cl), (M-4875, F, F, F, MeOCH2, F), (M-4876, F, F, F, MeOCH2, CF3), (M-4877, F, F, F, MeOCH2, Br), (M-4878, F, F, F, MeOCHa, CH3), (M-4879, F, F, F, EtOCH2, Η), (M-4880, F, F, F, EtOCH2, Cl), (M-4881，F, F, F, EtOCH2, F), (Μ·4882, F, F, F, EtOCH2, CF3), (M-4883, F，F，F, EtOCH2, Br), (M-4884, F， F, F, EtOCH2, CH3), (M-4885, F, F, F, EtOCH2CH2, Η), (M-4886, F, F，F, EtOCH2CH2, Cl), (M-4887, F, F, F, EtOCH2CH2, F), (M-4888, F, F, F, EtOCH2CH2, CF3), (M-4889, F, F, F, EtOCH2CH2, Br), (M-4890, F, F, F, EtOCH2CH2, CH3), (M-4891, F, F, F, MeOCH2CH2〇CH2CH2, Η), (M-4892, F，F, F, MeOCH2CH2〇CH2CH2, Cl), (Μ·4893, F, F, F, MeOCH2CH2〇CH2CH2, F), (M-4894, F, F, F, MeOCH2CH2〇CH2CH2, CF3), (M-4895, F, F, F, MeOCH2CH2〇CH2CH2, Br), (M-4896, F, F, F, MeOCH2CH2〇CH2CH2, CH3), (M-4897, F, F, F, MeOCH2CH2, Η), (M-4898, F, F, F, MeOCH2CH2, Cl), (Μ·4899, F, F, F, MeOCH2CH2, F), (M-4900, F, F, F, MeOCH2CH2, CF3), (M-4901，F，F，F， MeOCH2CH2, Br)，（M-4902, F, F, F, MeOCH2CH2, CH3), (M-4903, F, F，F， HOCH2,H)，（M-4904,F,F,F,HOCH2,C1),(M-4905,F,F,F,HOCH2,F),(M· 4906, F, F, F, HOCH2, CF3), (M-4907, F, F, F, HOCH2, Br), (M-4908, F, F, F， HOCH2, CHa), (M-4909, F, F, F, HOCH2CH2, Η), (M-4910, F, F, F, HOCH2CH2, Cl), (M-4911, F, F, F, HOCH2CH2, F), (M-4912, F, F, F, HOCH2CH2, CFa), (M-4913, F, F, F, HOCH2CH2, Br), (M-4914, F, F, F, HOCH2CH2, CHa), (M-4915, F, F, F, HOCH2CH2CH2, Η), (M-4916, F, F, F, HOCH2CH2CH2, Cl), (M-4917, F, F, F, HOCH2CH2CH2, F), (M-4918, F, F, F, HOCH2CH2CH2, CFs), (M-4919, F, F, F, 169 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --ί--I l· I I I I ills — ^- — — — — 1 — I (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 五齡)，) (M-4920, F, F, F, HOCH2CH2CH2, CHa), (M-4921, F, F, F, HOCH2CH2CH2CH2, Η), (M-4922, F, F, F, HOCH2CH2CH2CH2, Cl), (M-4923, F, F, F, HOCH2CH2CH2CH2, F), (M-4924, F, F, F, HOCH2CH2CH2CH2, CF3), (M-4925, F, F, F, HOCH2CH2CH2CH2, Br), (M-4926, F, F, F, HOCH2CH2CH2CH2, CH3), (M-4927, F, F, F, ΗΟΟΗ2〇Η2〇Η2〇Η2〇Ιΐ2, II), (M-4928, F, F, F, HOCH2CH2CH2CH2CH2, Cl), (M-4929, F, F, F, HOCH2CH2CH2CH2CH2, F), (M-4930, F, F, F, HOCH2CH2CH2CH2CH2, CFs), (M-4931, F, F, F, HOCH2CH2CH2CH2CH2, Br), (M-4932, F, F, F, HOCH2CH2CH2CH2CH2, CH3), (M-4933, F, F, F, HOCH2CH2OCH2CH2, Η), (M-4934, F, F, F, HOCH2CH2OCH2CH2, Cl), (M-4935, F, F, F, HOCH2CH2OCH2CH2, F), (M-4936, F, F, F, HOCH2CH2OCH2CH2, CFa), (M-4937, F, F, F, HOCH2CH2OCH2CH2, Br), (M-4938, F, F, F, HOCH2CH2OCH2CH2, CHa), (M-4939, F, F, F, (Me)2N, H), (M-4940, F, F, F, (Me)2N, Cl), (M-4941, F, F, F, (Me)2N, F)，（M-4942, F，F，F, (Me)2N, CF3), (M-4943, F, F, F, (Me)2N, Br), (M-4944, F, F, F, (Me)2N, CH3), (M-4945, F, F, Fn:哌啶-4 -基甲基:,Η), (M-4946, F, F, F,哌啶-4 -基 甲基，Cl), (M-4947, F, F, F,哌啶-4 -基甲基，F), (M-4948, F, F, F, 哌啶-4 -基甲基，CF3), (M-4949, F, F, F,哌啶 _ 4 _ 基甲基，Br), (M-4950, F, F, F,哌啶-4 -基甲基:，CH3), (M-4951, F, F, F,環己基甲基,， Η), (M-4952, F, F, F,環己基甲基，Cl), (M-4953, F, F, F,環己基甲基丨， F), (M-4954, F, F, F,環己基甲基，CF3), (M-4955, F, F, F， 環己基甲基，6〇,(1\4-4956,卩,卩,？，環己基甲基!，（^3),(]^4957,?，卩, Cl, Η, Η), (M-4958, F, F, Cl, H, Cl), (M-4959, F, F, Cl, H, F), (M-4960, F, F, Cl, H, CF3), (M-4961, F, F, Cl, H, Br), (M-4962, F, F, Cl, H, CH3)，（M-4963, F，F，Cl， F, Η), (M-4964, F, F, Cl, F, Cl), (M-4965, F, F, Cl, F, F), (M-4966, F，F, Cl，F， CF3), (M-4967, F, F, Cl, F, Br), (M-4968, F, F, Cl, F, CH3), (M-4969, F, F, Cl, Cl， Η), (M-4970, F, F, Cl, Cl, Cl), (M-4971, F, F, Cl, Cl, F), (M-4972, F, F, Cl, Cl， 170 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公爱） 1284639 A7 B7 五、發明說明（切） (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 CF3), (M-4973, F, F, Cl, Cl, Br), (M-4974, F, F, Cl, Cl, CHa), (M-4975, F, F, Cl, CH3, Η), (M-4976, F, F, Cl, CH3, Cl), (M-4977, F, F, Cl, CH3, F), (M-4978, F, F, Cl, CH3, CFs), (M-4979, F, F, Cl, CHa, Br), (M-4980, F, F, Cl, CH3, CHa), (M-4981,F,F,Cl,Et,H),(M-4982,F,F,Cl,Et,Cl),(M-4983,F，F,Cl,Et,F),(M-4984, F, F, Cl, Et, CFs), (M-4985, F, F, Cl, Et, Br), (M-4986, F, F, Cl, Et, Cila), (M-4987, F, F, Cl, n-Pr, Η), (M-4988, F, F, Cl, n-Pr, Cl), (M-4989, F, F, Cl, n-Pr, F), (M-4990, F, F, Cl, n-Pr, CF3), (M-4991, F, F, Cl，n-Pr, Br), (M-4992, F，F， Cl, n-Pr, CH3), (M-4993, F, F, Cl, c-Pr, Η), (M-4994, F, F, Cl, c-Pr，Cl), (M-4995, F, F, Cl, c-Pr, F), (M-4996, F, F, Cl, c-Pr, CF3)，（M-4997, F, F, Cl，c-Pr, Br), (M-4998, F, F, Cl, c-Pr, CHa), (M-4999, F, F, Cl, i-Pr, Η), (M-5000, F, F, Cl, i-Pr, Cl), (M-5001, F, F, Cl, i-Pr, F), (M-5002, F, F, Cl, i-Pr, CFa), (M-5003, F, F, Cl, i-Pr, Br), (M-5004, F, F, Cl, i-Pr, CH3), (M-5005, F, F, Cl, n-Bu, Η), (M-5006, F, F, Cl, n-Bu, Cl), (M-5007, F, F，Cl, n-Bu, F), (M-5008, F, F, Cl, n-Bu, CF3)， (M-5009, F, F, Cl, n-Bu, Br), (M-5010, F, F, Cl, n-Bu, CH3), (M-5011, F, F, Cl, i-Bu, Η), (M-5012, F, F, Cl, i-Bu, Cl), (M-5013, F, F, Cl, i-Bu, F), (M-5014, F，F, Cl,i-Bu,CF3),(M-5015,F,F,Cl,i-Bu,Br),(M-5016,F,F,Cl,i-Bu,CH3),(M· 5017, F, F, Cl, sec-Bu, Η), (M-5018, F, F, Cl, sec-Bu, Cl), (M-5019, F, F, Cl, sec-Bu, F), (M-5020, F, F, Cl, sec-Bu, CF3), (M-5021, F, F, Cl, sec-Bu, Br), (M-5022, F, F, Cl, sec-Bu, CH3), (M-5023, F, F, Cl, n-Pen, Η), (M-5024, F, F, Cl, n-Pen, Cl), (M-5025, F, F, Cl, n-Pen, F), (M-5026, F, F, Cl, n-Pen, CFs), (M-5027, F, F, Cl, n-Pen, Br), (M^-5028, F, F, Cl, n-Pen, CHa), (M-5029, F, F, Cl, c-Pen, H), (M-5030, F, F, Cl, c-Pen, Cl), (M-5031, F，F, Cl, c-Pen, F), (M-5032, F, F, Cl, c-Pen, CFa), (M-5033, F, F, Cl, c-Pen, Br), (M-5034, F, F, Cl, c-Pen, CHa), (M-5035, F, F, Cl, n-Hex, Η), (M-5036, F, F, Cl, n-Hex, Cl), (M-5037, F, F, Cl, n-Hex, F), (M-5038, F, F, Cl, n-Hex, CFa), (M-5039, F, F, Cl, n-Hex, Br), (M-5040, F, F, Cl, n-Hex, CH3), (M-5041, F, F, Cl, c-Hex, Η), (M-6042, F, F, Cl, c-Hex, Cl), 171 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（ι7β) (M-5043, F, F, Cl, c-Hex, F), (M-5044, F, F, Cl, c-Hex, CF3), (M-5045, F, F, C1， c-Hex, Br), (M-5046, F, F, Cl, c-Hex, CH3), (M-5047, F, F, Cl, OH，Η), (M-5048, F, F, Cl, OH, Cl), (M-5049, F, F, Cl, OH, F), (M-5050, F, F, Cl, OH, CF3), (M· 5051, F, F, Cl, OH, Br), (M-5052, F, F, Cl, OH, CH3), (M-5053, F，F, Cl, EtO, H), (M-5054, F, F, Cl, EtO, Cl), (M-5055, F, F, Cl, EtO, F), (M-5056, F, P, Cl, EtO, CF3), (M-5057, F, F, Cl, EtO, Br), (M-5058, F, F, Cl, EtO, CH3), (Μ·5059, F, F, Cl, n-PrO, Η), (M-5060, F, F, Cl, n-PrO, Cl), (M-5061, F, F, Cl, n-PrO, F), (M-5062, F, F, Cl, n-PrO, CF3), (M-5063, F, F, Cl, n-PrO, Br), (M-5064, F, F，Cl， n-PrO, CH3), (M-5065, F, F, Cl, PhO, Η), (M-5066, F, F, Cl, PhO, Cl)，（M-5067, F, F, Cl, PhO, F), (M-5068, F, F, Cl, PhO, CF3), (M-5069, F, F, Cl, PhO, Br), (M-5070, F, F, Cl, PhO, CH3), (M-5071, F, F, Cl, BnO, Η), (M-5072, F, F, Cl, BnO, Cl), (M-5073, F, F, Cl, BnO, F), (M-5074, F, F, Cl, BnO, CF3), (M-5075, F, F, Cl, BnO, Br), (M-5076, F, F, Cl, BnO, CH3), (M-5077, F，F, Cl, PhCH2CH2〇, Η), (M-5078, F, F, Cl, PhCH2CH2〇, Cl), (M-5079, F, F, Cl, PhCH2CH2〇, F), (M-5080, F, F, Cl, PhCH2CH2〇, CFs), (M-5081, F, F, Cl, PhCH2CH2〇, Br), (M-5082, F, F, Cl, PhCH2CH2〇, CH3), (M-5083, F, F, Cl, CF3〇, Η), (M-5084, F， F, Cl, CF3〇, Cl), (M-5085, F, F, Cl, CF3〇, F), (M-5086, F, F, Cl, CF3〇, CF3), (M-5087, F, F, Cl, CF3〇, Br), (M-5088, F, F, Cl, CF3〇, CH3), (M-5089, F, F, Cl, Ph, Η), (M-5090, F, F, Cl, Ph, Cl), (M-5091，F, F, Cl, Ph, F), (M-5092, F, F, Cl, Ph, CF3), (M-5093, F, F, Cl, Ph, Br), (M-5094, F, F, Cl, Ph, CH3), (M-5095, F，F， Cl, 4-F-Ph, Η), (M-5096, F, F, Cl, 4-F-Ph, Cl), (M-5097, F, F，Cl, 4-F-Ph, F)， (M-5098, F, F, Cl, 4-F-Ph, CF3), (M-5099, F, F, Cl, 4-F-Ph, Br), (M-5100, F, F，Cl， 4-F-Ph, CH3), (M-5101, F, F, Cl, 4-CF3-Ph, Η), (M-5102, F, F，Cl, 4-CF3-Ph, Cl)， (M-5103, F, F, Cl, 4-CF3-Ph, F), (M-5104, F, F, Cl, 4-CF3-Ph, CF3)，（M-5105, F， F, Cl, 4-CF3-Ph, Br), (M-5106, F, F, Cl, 4-CF3-Ph, CHa), (M-5107, F, F, Cl, 4-(Me)2N-Ph, Η), (M-5108, F, F, Cl, 4-(Me)2N-Ph, Cl), (M-5109, F, F, Cl, 4· 172 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公爱) " 一 --2----^-----------1 ^--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 ___B7____ 五、發明說明（…） (Me)2N-Ph,F),(M-5110,F,F,Cl,4-(Me)2N-Ph,CF3),(M-5111,F,F，Cl,4-(Me)2N-Ph, Br), (M-5112, F, F, Cl, 4-(Me)2N-Ph, CHa), (M-5113, F, F, Cl, 4-OH-Ph, H>, (M-5114, F, F, Cl, 4-OH-Ph, Cl), (M-5115, F, F, Cl, 4-OH-Ph, F), (M-5116, F, F, Cl, 4-OH-Ph, CF3), (M-5117, F，F, Cl, 4-OH-Ph, Br), (M-5118, F, F, Cl, 4-OH-Ph, CH3), (M-5119, F, F, Cl, 3,4-di-F-Ph, Η), (M-5120, F, F, Cl, 3,4-di-F-Ph,Cl),(M-5121,F,F,Cl,3,4-di-F-Ph,F),(M-5122,F,F,Cl,3,4-di· F-Ph, CF3), (M-5123, F, F, Cl, 3,4-di-F-Ph, Br), (M-5124, F, F, Cl, 3,4-di-F-Ph, CH3), (M-5125, F, F, Cl, 4-COOH-Ph, Η), (M-5126, F, F, Cl, 4-COOH-Ph, Cl), (M-5127,F,F,Cl,4-COOH-Ph,F),(M-5128,F,F,Cl,4-COOH-Ph，CF3)，（M-5129, F, F, Cl, 4-COOH-Ph, Br), (M-5130, F, F, Cl, 4-COOH-Ph, CH3), (M-5131， F, F, Cl, Bn, H)，（M-5132, F, F, Cl, Bn, Cl), (M-5133, F，F, Cl，Bn, F)，（M_5134, F, F, Cl, Bn, CF3), (M-5135, F, F, Cl, Bn，Br), (M-5136, F, F，Cl, Bn, CH3)， (M-5137, F, F, Cl, 4-F-Bn, Η), (M-5138, F, F, Cl, 4-F-Bn, Cl), (M-5139, F, F, Cl， 4-F-Bn, F), (M-5140, F, F, Cl, 4-F-Bn, CF3), (M-5141, F, F, Cl，4-F-Bn, Br), (M-5142, F, F, Cl, 4-F-Bn, CH3), (M-5143, F, F, Cl, 2-Py, Η), (M-5144, F，F, Cl, 2- Py, Cl), (M-5145, F, F, Cl, 2-Py, F), (Μ·5146, F, F, Cl, 2-Py, CF3>, (M-5147, F, F, Cl, 2-Py, Br), (M-5148, F, F, Cl, 2-Py, CH3), (M-5149, F, F, Cl, 3-Py, H), (M-5150, F, F, Cl, 3-Py, Cl), (M-5151, F, F, Cl, 3-Py, F), (M-5152, F, F, Cl, 3-Py, CF3), (M-5153, F, F, Cl, 3-Py，Br), (M-5154, F, F, Cl, 3-Py, CH3), (M-5155, F, F， Cl, 4-Py, Η), (M-5156, F, F, Cl, 4-Py, Cl), (M-5157, F, F, Cl，4-Py，F)，（M-5158, F, F, Cl，4-Py, CF3), (M-5159, F, F, Cl, 4-Py, Br), (M-5160, F，F，Cl，4-Py，CH3)， (M-5161, F, F, Cl, 2-Th, Η), (M-5162, F, F, Cl, 2-Th, Cl), (M-5163, F, F, Cl, 2-Th, F), (M-5164, F, F, Cl, 2-Th, CF3), (M-5165, F, F, Cl, 2-Th, Br)，（M-5166, F， F, Cl, 2-Th, CH3), (M-5167, F, F, Cl, 3-Th, Η), (M-5168, F, F, Cl, 3-Th，Cl)， (M-5169, F, F, Cl, 3-Th, F)，（M-5170, F, F, Cl，3-Th, CF3)，（M-5171, F, F，Cl， 3- Th, Br), (M-5172, F, F, Cl, 3-Th，CH3), (M-5173, F，F, Cl,吡哩-2-基，H)， 173 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --:----1-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) [284639 (M- A7 B7 五 i 唤-2-基bCl), (M-5175, F, F, Cl, 吡唑-2-棊，F>, 5176, F, F, Cl,吡唑-2-基,CF3), (M-5177, F, F, Cl,吡哩-2-基,Br), (M· 5178, F, F, Cl,吡唑-2_基 *CH3), (M-5179, F, F, Cl,吡唑-3_基;，Η), (M· 5180, F, F, Cl,吡唑-3-基 Cl), (M-5181, F, F, Cl,吡唑-3-棊，F), (M-5182, F, F, Cl,吡唑-3 -基，CF3), (M-5183, F, F, Cl,吡唑-3 -棊，13r), (Μ·δ184, F, F, Cl,吡唑-3·基，CH3), (M-5185, F, F, Cl,嘧啶-2-基，H), (M-5186, F, F, Cl， 嘧陡-2-基，Cl), (M-5187, F, F, Cl,嘧啶-2·棊，F), (M-5188, F，F, Cl, 嘧陡·2-基，CF3), (M-5189, F, F, Cl,嘧啶-2-基，Br), (M-5190, F，F，Cl， 嘧啶-2-基，CH3), (Μ·5191, F, F, Cl，嗯啶基，Η), (M-5192, F，F, Cl, 嘧陡-4-基，Cl), (M-5193, F, F, Cl,嘧啶-4·基，F), (M-5194, F, F, Cl, 嘧陡-4-基，CF3), (M-5195, F, F, Cl,嘧啶-4-基，Br), (M-5196, F, F，Cl， 嘧啶-4-基，CH3), (M-5197, F, F, Cl,嘧啶-5-基，Η), (M-5198, F，F, Cl, _ i 嘧啶-5-基，Cl), (M-5199, F, F, Cl,嘧啶-5-基，F), (M-5200, F, F，Cl,
. I 嘧啶-5-基，CF3), (M-5201, F, F, Cl·嘧啶-5-基，Br), (M-5202, F, F, Cl, 躕啶-5-塞，CH3), (M-5203, F, F, Cl, HOOCCH2CH2CH2, Η), (M-5204, F, F， Cl, HOOCCH2CH2CH2, Cl), (M-5205, F, F, Cl, HOOCCH2CH2CH2, F), (M-5206, F, F, Cl, HOOCCH2CH2CH2, CFs), (M-6207, F, F, Cl, HOOCCH2CH2CH2, Br), (M-5208, F, F, Cl, HOOCCH2CH2CH2, CHa), (M-5209, F, F, Cl, HOOCCH2CH2CH2CH2, Η), (M-5210, F, F, Cl, HOOCCH2CH2CH2CH2, Cl), (M-5211, F, F, Cl, HOOCCH2CH2CH2CH2, F), (M-5212, F, F, Cl, HOOCCH2CH2CH2CH2", CFa), (M-6213, F, F, Cl, HOOCCH2CH2CH2CH2, Br), (M-5214, F, F, Cl, HOOCCH2CH2CH2CH2, CHa), (M-5215, F, F, Cl, (Me>2NCOCH2CH2CH2CH2, Η), (M-5216, F, F, Cl, (Me)2NCOCH2CH2CH2CH2， Cl), (M-5217, F, F, Cl, (Me)2NCOCH2CH2CH2CH2, F), (M-5218, F, F, Cl， (Me)2NCOCH2CH2CH2CH2, CF3), (M-5219, F, F, Cl, (Me)2NCOCH2CH2CH2CH2, Br), (M-5220, F, F, Cl, (Me)2NCOCH2CH2CH2CH2, CH3), (M-5221，F，F，Cl， 174 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） —.—：------裝--------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7____ 五、發明說明。”） (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-5222, F, F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-5223, F, F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-5224, F, F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-5225, F，F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-5226, F, F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-5227, F, F, Cl, MeOCH2, Η), (M-5228, F, F, Cl, MeOCH2, Cl), (M-5229, F, F, Cl, MeOCH2, F), (M-5230, F, F, Cl， MeOCH2, CF3), (M-5231, F,.F, Cl, MeOCH2, Br), (M-5232, F, F, Cl, MeOCH2, CH3), (M-5233, F, F, Cl, EtOCH2, Η), (M-5234, F, F, Cl, EtOCH2, Cl), (M-5235, F, F, Cl, EtOCH2, F), (M-5236, F, F, Cl, EtOCH2, CF3), (M-5237, F, F, Cl, EtOCH2, Br), (M-5238, F, F, Cl, EtOCH2, CH3), (M-5239, F, F, Cl, EtOCH2CH2, Η), (M-5240, F, F, Cl，EtOCH2CH2, Cl), (M-5241, F, F, Cl, EtOCH2CH2, F)， (M-5242, F, F, Cl, EtOCH2CH2, CFs), (M-5243, F, F, Cl, EtOCH2CH2, Br), (M-5244, F, F, Cl, EtOCH2CH2, CH3), (M-5245, F, F, Cl, MeOCH2CH2〇CH2CH2, H), (M-5246, F, F, Cl, MeOCH2CH2〇CH2CH2, Cl), (M-5247, F, F, Cl, MeOCH2CH2〇CH2CH2, F), (M-5248, F, F, Cl, MeOCH2CH2OCH2CH2, CF3), (Μ·5249, F, F, Cl, MeOCH2CH2〇CH2CH2, Br), (M-5250, F, F, Cl, MeOCH2CH2OCH2CH2, CH3), (M-5251, F, F, Cl, MeOCH2CH2, Η), (M-5252, F， F, Cl, MeOCH2CH2, Cl), (M-5253, F, F, Cl, MeOCH2CH2, F)，（M-5254, F，F，Cl， MeOCH2CH2, CF3), (M-5255, F, F, Cl, MeOCH2CH2, Br)，（M-5256, F, F, Cl, MeOCH2CH2, CHs), (M-6257, F, F, Cl, HOCH2, Η), (M-5258, F, F, Cl, HOCH2, Cl), (M-5259, F, F, Cl, HOCH2, F), (M-5260, F, F, Cl, HOCH2, CF3)，（M-5261，F, F, Cl, HOCH2, Br), (M-5262, F, F, Cl, HOCH2, CH3), (M-5263, F, F, Cl, HOCH2CH2, Η), (M-5264, F, F, Cl, HOCH2CH2, Cl), (M-5265, F, F, Cl, HOCH2CH2, F), (M-5266, F, F, Cl, HOCH2CH2, CFa), (M-5267, F, F, Cl, HOCH2CH2, Br), (M-5268, F, F, Cl, HOCH2CH2, CHa), (M-5269, F, F, Cl, 175 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） " __：—^-------------^--------- (請先閱讀背面之注意事項再填寫本頁) A7 1284639 __ B7 ____ 五、發明說明（ HOCH2CH2CH2, Η), (M-6270, F, F, Cl, HOCH2CH2CH2, Cl), (M-5271, F, F, Cl, HOCH2CH2CH2, F), (M-5272, F, F, Cl, HOCH2CH2CH2, CFa), (M-5273, F, F, Cl, HOCH2CH2CH2, Br), (M-5274, F, F, Cl, HOCH2CH2CH2, CHa), (M-5275, F, F, Cl, HOCH2CH2CH2CH2, Η), (M-5276, F, F, Cl, HOCH2CH2CH2CH2, Cl). (M-5277, F, F, Cl, HOCH2CH2CH2CH2, F), (M-5278, F, F, Cl, HOCH2CH2CH2CH2, CFs), (M-5279, F, F, Cl, HOCH2CH2CH2CH2, Br), (M-6280, F, F, Cl, HOCH2CH2CH2CH2; CHs), (M-5281, F, F, Cl, HOCH2CH2CH2CH2CH2, Η), (M-5282, F, F, Cl, HOCH2CH2CH2CH2CH2, Cl), (M-5283, F, F, Cl, HOCH2CH2CH2CH2CH2, F), (M-5284, F, F, Cl, HOCH2CH2CH2CH2CH2, CFa), (M-5285, F, F, Cl, HOCH2CH2CH2CH2CH2, Br), (M-5286, F, F, Cl, HOCH2CH2CH2CH2CH2, CHa), (M-5287, F, F, Cl, HOCH2CH2OCH2CH2, H), (M-5288, F, F, Cl, HOCH2CH2OCH2CH2, Cl), (M-5289, F, F, Cl, HOCH2CH2OCH2CH2, F), (M-5290, F, F, Cl, HOCH2CH2OCH2CH2, CFa), (M-5291, F, F, Cl, HOCH2CH2OCH2CH2, Br), (M-5292, F, F, Cl, HOCH2CH2〇CH2CH2, CH3), (M-5293, F, F, Cl, (Me)2N, Η), (M-5294, F, F, Cl, (Me)2N, Cl), (M-5295, F, F, Cl, (Me)2N, F), (M-5296, F, F, Cl, (Me)2N, CF3), (M-5297, F, F, Cl, (Me)2N, Br), (M-5298, F, F, Cl, (Me)2N, CH3), (M-5299, F, F， Cl,哌啶-4 ·基甲基，H), '(M-5300, F, F, Cl,哌啶-4 基甲基，Cl)， (M-5301, F, F, Cl,哌啶-4 ·基甲基，F), (M-5302, F, F, Cl,哌啶-4 -基 甲基，CF3), (M-5303, F, F, Cl,哌啶-4-基甲基，Br), (M-5304, F, F, Cl, 哌啶-4 基甲基，CH3), (M-5305, F, F, Cl,環己基甲基，H>, (M-53〇G, F, F, Cl,環己基甲基，Cl), (M-5307, F,、F, Cl,環己基甲基* F), (M· 5308, F, F, Cl,環 H 基甲基，CF3), (Μ·5309, F, F，Cl,環己基甲基，Br), (Μ·5310, F, F, Cl,環己基甲基，CH3), (M-5311, F, CH3, Η, Η, H)，（Μ·5312, F, CH3, Η, H, Cl), (M-5313, F，CH3, Η, H, F), (M-5314, F, CH3, Η, H, CF3), (M-5315, F, CH3, Η, H, Br), (M-5316, F, CH3, Η, H, CH3), (M-5317, F，CH3, H，F， 176 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） --,-----------------^--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 經濟部智慧財產局員工消費合作社印製 五 61¾¾¾¾ /, ch2 H, F, Cl), (M-5319, F, CH3, H, F, F), (Μ·5320, F，CH3, H， F, CF3), (M-5321, F, CH3, H, F, Br), (M-5322, F, CH3, H, F, CH3), (M-5323, F， CH3, H, Cl, Η), (Μ·5324, F, CH3, H, Cl, Cl), (M-5325, F, CH3, H, Cl，F), (M-5326, F, CH3, H, Cl, CF3), (M-5327, F, CH3, H, Cl, Br), (M-5328, F, CH3, H, Cl, CH3)， (M-5329, F, CHa, H, CH3, Η), (M-5330, F, CH·% 11, CHa, Gl), (Μ·δ331，F，Cil3, 11， CH3, F), (M-5332, F, CH3, H, CHs, CFs), (M-5333, F, CHa, H, CHa, Br), (M-5334, F, CH3, H, CHa, CHs), (M-5335, F, CHa, H, Et, Η), (M-5336, F, CHs, H, Et, Cl), (M-5337, F, CH3, H, Et, F), (Μ·5338, F, CH3, H, Et, CF3), (M-5339, F, CH3, H, Et， Br), (M-5340, F, CH3, H, Et, CH3), (M-5341, F, CH3, H, n-Pr, Η), (M-5342, F， CH3, H, n-Pr, Cl), (M-5343, F, CHa, H, n-Pr, F), (M-5344, F, CHs, H, n-Pr, CFa), (M-5345, F, CH3, H, n-Pr, Br), (M-5346, F, CH3, H, n-Pr, CH3), (M-5347, F, CH3, H, c-Pr, Η), (Μ·5348, F, CH3, H, c-Pr, Cl), (M-5349, F, CH3, H, c-Pr, F), (M-5350, F, CHs, H, c-Pr, CFa), (M-5351, F, CHs, H, c-Pr, Br), (M-5352, F, CHa, H, c-Pr, CH3), (M-5353, F, CH3, H, i-Pr, Η), (M-5354, F, CH3, H, i-Pr, Cl), (M-5355, F, CH3, H, i-Pr, F), (M-5356, F, CH3, H, i-Pr, CF3), (M-5357, F, CH3, H, i-Pr, Br), (M-5358, F, CH3, H, i-Pr, CH3), (M-5359, F, CH3, H, n-Bu, Η), (M-5360, F，CH3, H, n-Bu, Cl), (M-5361, F, CH3, H, n-Bu, F), (M-5362, F, CH3, H, n-Bu, CF3), (M-5363, F, CHs, H, n-Bu, Br), (M-5364, F, CHa, H, n-Bu, CHa), (M-5365, F, CHa, H, i-Bu, Η), (M-5366, F, CH3, H, i-Bu, Cl), (M-5367, F, CH3, H, i-Bu, F), (M-5368, F, CH3, H, i-Bu, CF3)，（M-5369, F, CH3, H, i-Bu, Br), (M-5370, F，CH3, H, i-Bu, CHa), (M-5371；F, CHs, H, sec-Bu, Η), (M-5372, F, CHs, H, sec-Bu, Cl), (M-5373, F, CHa, H, sec-Bu, F), (M-5374, F, CHa, H, sec-Bu, CF3), (M-5375, F, CH3, H, sec-Bu, Br), (M-5376, F, CH3, H, sec-Bu, CH3>，（M-5377, F, CH3, H, n-Pen, Η), (M-5378, F, CHa, H, n-Pen, Cl), (M-5379, F, CHa, H, n-Pen, F), (M-5380, F, CHa, H, n-Pen, CF3), (M-5381, F, CHa, H, n-Pen, Br), (M-5382, F, CH3, H, n-Pen, CH3), (M-5383, F, CH3, H, c-Pen, Η), (M-5384, F, CHa, H, c-Pen, Cl), 177 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ---,0------------ (請先閱讀背面之注意事項再填寫本頁) tr--------- 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（Ά) (M-5385, F, CH3, H, c-Pen, F), (M-5386, F, CH3, H, c-Pen, CF3), (Μ·5387, F, CH3, H, c-Pen, Br), (Μ·5388, F, CH3, H, c-Pen, CH3), (M-5389, F, CH3, H, n-Hex，H), (M-5390, F, CH3, H, n-Hex, Cl), (Μ·5391, F, CH3, H, n-Hex, F), (Μ·5392, F, CH3, H, n-Hex, CFa), (M-5393, F, CHa, H, n-Hex, Br), (M-6394, F, CHa, H, n-Hex, CHs), (M-5395, F, CHs, H, c-Hex, Η), (M-5396, F, CHs, H, c-Hex, Cl), (M-5397, F, CH3, H, c-Hex, F), (M-5398, F, CHa, H, c-Hex, CFs), (M-5399, F, CHa, H, c-Hex, Br), (M-5400, F, CH3, H, c-Hex, CHs), (M-5401, P, CHa, H, OH, Η), (M-5402, F, CH3, H, OH, Cl), (M-5403, F, CH3, H, OH, F), (M-5404, F, CH3, Η, OH， CF3), (M-5405, F, CH3, H, OH, Br), (M-5406, F, CII3, H, OH, CH3), (M-5407, F, CH3, H, EtO, Η), (M-5408, F, CH3, H, EtO, Cl), (M-5409, F, CH3, H，EtO, F)， (M-5410, F, CH3, H, EtO, CF3), (M-5411, F, CH3, H, EtO, Br), (M-5412, F, CH3, H, EtO, CH3), (M-5413, F, CH3, H, n-PrO, Η), (M-5414, F, CHs，H, n-PrO, Cl), (M-5415, F, CHa, H, n-PrO, F), (M-5416, F, CHa, H, n-PrO, CFa), (M-5417, F, CH3, H, n-PrO, Br), (M-5418, F, CHs, H, n-PrO, CHa), (M-5419, F, CHa, H, PhO, Η), (M-5420, F, CHa, H, PhO, Cl), (M-6421, F, CHa, H, PhO, F), (M-5422, F, CH3> H, PhO, CF3), (Μ·5423, F, CH3, H, PhO, Br), (M-5424, F, CH3, H, PhO, CH3)， (M-5425, F, CHs, Η, BnO, Η), (M-5426, F, CHa, H, BnO, Cl), (M-5427, F, CHa, H, BnO, F), (M-5428, F, CH3, H, BnO, CF3), (M-5429, F, CH3, H, BnO, Br), (M-5430, F, CH3, H, BnO, CH3), (M-5431, F, CH3, H, PhCH2CH20, Η), (M-5432, F, CH3, H, PhCH2CH2〇, Cl), (M-5433, F, CH3, H, PhCH2CH2〇, F), (M-5434, F, CH3, H, PI1CH2CH2O, CF3), (M-5435, F, CH3, H, PhCH2CH2〇, Br), (M-5436, F，CH3, H， PhCH2CH2〇, CHs), (M-5437, F, CHa, H, CF3〇, Η), (M-5438, F, CHa, H, CF3〇, Cl), (Μ·5439, F, CH3, H, CF3〇, F), (M-5440, F, CH3, II, CF3〇, CF3)，（M-5441, F， CHs, H, CFaO, Br), (M-5442, F, CHa, H, CF3〇, CHa), (M-6443, F, CHa, H, Ph, H), (M-5444, F, CH3, H, Ph, Cl), (M-5445, F, CH3, H, Ph, F), (M-5446, F, CH3, H, Ph, CF3), (M-5447, F, CH3, H, Ph, Br), (M-5448, F, CH3, H, Ph, CH3), (M-5449, F, 178 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --K----.-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五、發明說明 CHa, η, 4-F-Ph, Η), (M-5450, F, CHa, H, 4-F-Ph, Cl), (M-5451, F, CHs, H, 4-F-Ph, F), (M-5452, F, CH3, H, 4-F-Ph, CFa), (M-6453, F, CHa, H, 4-F-Ph, Br), (M.5454, F, CH3, H, 4-F-Ph, CH3), (M-5455, F, CH3, H, 4-CF3-Ph, Η), (M-5456, F，CH3, H, 4-CF3-Ph, Cl), (M-5457, F, CHa, H, 4-CF3-Ph, F), (M-5458, F, CH3, H· 4-CF3.Ph, CFa), (M-6459, F, CHs, H, 4-CF3-Ph, Br), (M-6460, F, CHs, H, 4-CP3-Ph, CHa), (M-5461, F, CHa, H, 4-(Me)2N-Ph, Η), (M-5462, F, CHa, H, 4-(Me)2N.Ph, Cl), (M-5463, F, CHa, H, 4-(Me)2N-Ph, F), (M-5464, F, CHa, H, 4-(Me)2N-Ph, CF3), (M-5465, F, CH3, H, 4-(Me)2N-Ph, Br), (M-5466, F, CHs, H, 4-(Me)2N.Ph, CHs), (M-5467, F, CHa, H, 4-OH.Ph, H), (M-5468, F, CHa, II, 4-〇H-Ph, Cl), (Μ·5469, F, CH3, H, 4-OH-Ph, F), (M-5470, F, CH3, H, 4-OH-Ph, CF3), (M-5471, F, CH3, H, 4-OH-Ph, Br), (M-5472, F, CH3, H, 4-OH-Ph, CH3), (M-5473, F, CH3, H, 3,4-di-F-Ph, Η), (M-5474, F, CH3, H, 3,4-di-F-Ph, Cl)， (M-5475, F, CH3, H, 3,4-di-F-Ph, F), (M-5476, F, CH3, H, 3,4-di-F-Ph, CF3>， (M-5477, F, CH3, H, 3,4-di-F-Ph, Br), (M-5478, F, CH3, H, 3,4-di-F-Ph, CH3)， (M-5479, F, CH3, H, 4-COOH-Ph, Η), (M-5480, F, CH3, H, 4-COOH-Ph, Cl)， (Μ·5481, F, CH3, H, 4-COOH-Ph, F)，（M-5482, F, CH3, H, 4-COOH-Ph, CF3), (M-5483, F, CH3, H, 4-COOH-Ph, Br), (M-5484, F, CH3, H, 4-COOH-Ph, CH3)， (M-5485, F, CH3, Η, Bn, Η), (M-5486, F, CH3, H, Bn, Cl), (M-5487, F, CH3, H， Bn, F), (M-5488, F, CH3, H, Bn, CF3), (M-5489, F, CH3, H, Bn, Br), (M-5490, F， CH3, H，Bn, CH3), (M-5491, F, CH3, H, 4-F-Bn, Η), (M-5492, F, CH3, H，4-F-Bn， Cl), (M-5493, F, CH3, H, 4-F-Bn, F), (M_5494, F, CH3, H, 4-F-Bn, CF3), (Μ·5495, F, CH3, H，4-F-Bn, Br), (M-5496, F, CH3, H, 4-F-Bn, CH3), (M-5497, F, CH3, H， 2-Py, Η), (M-5498, F, CHs, H, 2-Py, Cl), (M-5499, F, CHs, H, 2-Py, F), (M-5500, F, CHa, H, 2-Py, CFa), (M-5501, F, CHa, H, 2-Py, Br), (M-5502, F, CHa, H, 2-Py, CH3), (M-5503, F, CH3, H, 3-Py, Η), (M-5504, F, CH3, H, 3-Py, Cl), (M-5505, F， CH3, H, 3-Py, F), (M-5506, F, CH3, H, 3-Py, CF3), (M-5507, F, CH3, H, 3-Py, Br)， 179 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） (請先閱讀背面之注意事項再填寫本頁) «1 H ^1 ϋ 訂---------身· 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 _B7 ； _ 五、發明說明Ο W) (M-5508, F, CH3, H, 3-Py, CH3), (M-5509, F, CH3, H, 4-Py, Η), (M-5510, F, CH3， H, 4-Py, Cl), (Μ·5511, F, CH3, H, 4-Py, F), (M-5512, F，CH3, H, 4-Py, CF3), (M-5513, F, CH3, H, 4-Py, Br), (M.5514, F, CH3, H, 4-Py, CH3), (M-5515, F, CH3， H, 2-Th, Η), (M-5516, F, CH3, H, 2-Th, Cl), (M-5517, F, CH3, H，2-Th, F), (M· 5518, F, CHa, H, 2-Th, CF3), (M-5519, F, CH3, H, 2-Th, Br), (M-5520, F, CH3, H, 2- Th, CH3), (M-5521, F, CHa, H, 3-Th, Η), (M-5522, F, CHa, H, 3-Th, Cl), (M-5523, F, CH3, H, 3-Th, F), (M-5524, F, CH3, H, 3-Th, CF3), (M-5525, F, CH3, H， 3- Th, Br), (M-5526, F, CH3, H, 3-Th, CH3), (M-5527, F, CH3, H，吡唑-2-基， Η), (M-5528, F, CH3, H,吡唑-3-基，Cl), (M-5529, F, CH3, H,吡唑-2-基， F), (M-5530, F, CH3, H,吡唑-3-基，CF3), (M-5531, F, CH3, H,吡唑·2·基, Br), (M-5532, F, CH3, Η,吡唑·2-基，CH3), (M-5533, F, CH3, Η,壯唑-3-基， yl, Η), (M-5534, F, CH3, Η,吡唑-3-基，Cl), (M-5535, F, CH3, Η,吡唑-3·基, yl, F), (M-5536, F, CH3, Η,吡唑-3-基，CF3), (M-5537, F, CH3, Η,吡唑-3-基，Br), (M-5538, F, CH3, Η,吡唑-3-基，CH3), (Μ·5539, F, CH3, Η, 嘧啶-2-基，H), (M-5540, F, CH3, H,嘧啶-2·基，Cl), (M-5541，F，CH3，H， 嘧啶-2·基，F), (M-5542, F, CH3, H,嘧啶-2-基，CF3), (M-5543, F, CH3， H,嘧啶-2-基·，Br), (M-5544, F, CH3, H,嘧啶-2-基，CH3), (M-5545, F， CH3, H,嘧、n定-4-基，H), (M-5546, F, CH3, H，嘧啶-4-基I，Cl)，（Μ·5547, F， CH3, H,嘧啶-4-基，F), (M-5548, F, CH3, H,嘧啶-4 -基，CF3), (M-5549， F, CH3, H,嘧啶-4-基，Br), (Μ·5550, F, CH3, H,嘧啶-4·基，CH3), (M-5551, F, CH3, H,嘧啶-5-基，Η), (M-5552, F, CH3, H,嘧啶-5-棊，Cl), (M-5553, F, CH3,· H,嘧啶-5 -棊，F), (M-5554, F, CH3, H,嘧啶-5 -基， CF3), (Μ·5555, F，CH3, H,嘧啶-5-基，Br), (M-5556, F, CH3, H， 嘧啶-5-基,CHa), (M-5557, F, CHs, H, HOOCCH2CH2CH2, Η), (M-5558, F, CH3, H, HOOCCH2CH2CH2, Cl), (M-5559, F, CHa, H, HOOCCH2CH2CH2, F), (M-5560, F, CHs, H, HOOCCH2CH2CH2, CF3), (M-5561, F, CH3, H, 180 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） --“--------- ! — — ！ β· — !----- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五、發明說明（ϊ7?) HOOCCH2CH2CH2, Br), (M-6562, F, CHa, H, HOOCCH2CH2CH2, CHa), (M-5563, F, CHs, H, HOOCCH2CH2CH2CH2, Η), (M-5564, F, CHa, H, HOOCCH2CH2CH2CH2, Cl), (M-5565, F, CHa, H, HOOCCH2CH2CH2CH2, F), (M-5566, F, CHa, H, HOOCCH2CH2CH2CH2, CFs), (M-6567, F, CHs, H, HOOCCH2CH2CH2CH2, Br), (M-5568, F, CHa, H, HOOCCH2CH2CH2CH2, CHa), (M-5569, F, CH3, H, (Me)2NCOCH2CH2CH2CH2, Η), (M-5570, F, CH3, H, (Me)2NCOCH2CH2CH2CH2, Cl), (M-5571, F, CH3, H, 經濟部智慧財產局員工消費合作社印製 -------------訂- (請先閱讀背面之注意事項再填寫本頁) (Me)2NCOCH2CH2CH2CH2, F), (M-5572, F, CH3, H, (Me)2NCOCH2CH2CH2CH2, CF3), (M-5573, F, CH3, H, (Me)2NCOCH2CH2CH2CH2, Br)，（M-5574, F, CH3, H， (Me)2NCOCH2CH2CH2CH2, CH3), (M-5575, F, CH3, H, (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-5576, F, CH3, H, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-5577, F, CHs, H, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-5578, F, CH3, H, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-5579, F, CH3, H, (Me)2NCOCH2CH2CH2CH2CH2, Br)，（M-5580, F, CH3, H, (Me)2NCOCH2CH2CH2CH2CH2, CH3>, (M-5581, F, CH3, H, MeOCH2, Η), (M· 5582, F, CHs, H, MeOCH2, Cl), (M-5583, F, CHa, H, MeOCH2, F), (M-5584, F, CHa, H, MeOCH2, CFs), (M-5585, F, CHa, H, MeOCH2, Br), (M-5586, F, CH3, H, MeOCH2, CHs), (M-5587, F, CH3, H, EtOCH2, Η), (M-5588, F, CH3, H, EtOCH2, Cl),(M-5589,F,CH3,H,EtOCH2,F),(M-5590,F,CH3,H，EtOCH2,CF3),(M· 5591, F, CH3, H, EtOCH2, Br), (M-5592, F, CH3, H, EtOCH2, CH3), (M-5593, F, CH3, H, EtOCH2CH2, Η), (M-5594, F, CH3, H, EtOCH2CH2, Cl>，（M-5595, F, CH3, H, EtOCH2CH2, F), (M-5596, F, CHa, H, EtOCH2CH2, CF3), (M-5597, F, CHs, H, EtOCH2CH2, Br), (M-5598, F, CHa, H, EtOCH2CH2, CHa), (M-5599, F, CH3, H, MeOCH2CH2〇CH2CH2, Η), (M-5600, F, CH3, H, MeOCH2CH2〇CH2CH2, Cl), (M-5601, F, CH3, H, MeOCH2CH2〇CH2CH2, F)，（M-5602, F，CH3, H, 181 ^紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公爱) 1284639 A7 B7 五
Mimm〇(cuA2, 經濟部智慧財產局員工消費合作社印製 CF3), (M-5603, F，CH3, H, MeOCH2CH2OCH2CH2, Br)， (M-5604, F, CH3, H, MeOCH2CH2〇CH2CH2, CH3), (M-5605, F, CH3, H, MeOCH2CH2, Η), (M-5606, F, CH3, H, MeOCH2CH2, Cl), (M-5607, F, CH3, H, MeOCH2CH2, F), (M-5608, F, CH3, H, MeOCH2CH2, CF3), (M-5609, F, CH3, H， MeOCH2CH2, Br), (M-5610, F, CH3, H, MeOCthCth, Clia), (M-5611, F, Clh, 11， HOCH2, Η), (M-5612, F, CH3, H, HOCH2, Cl), (Μ·5613, F, CH3, H, HOCH2, F), (M-5614, F, CH3, H, HOCH2, CF3), (M-5615, F, CH3, H, HOCH2, Br), (M-5616, F， CH3, H, HOCH2, CHa), (M-5617, F, CH3, H, HOCH2CH2, Η), (M-5618, F, CH3, H, HOCH2CH2, Cl), (M-5619, F, CHa, H, HOCH2CH2, F), (M-5620, F, CHa, H, HOCH2CH2, CF3), (M-5621, F, CHs, H, HOCH2CH2, Br), (M-5622, F，CH3, H, HOCH2CH2, CH3), (M-5623, F, CH3, H, HOCH2CH2CH2, Η), (M-5624, F, CH3, H， HOCH2CH2CH2, Cl), (M-5625, F, CHa, H, HOCH2CH2CH2, F), (M-5626, F, CHs, H, HOCH2CH2CH2, CFa), (M-5627, F, CHs, H, HOCH2GH2CH2, Br), (M-5628, F, CH3, H, HOCH2CH2CH2, CH3), (M-5629, F, CHs, H, HOCH2CH2CH2CH2, H), (M-5630, F, CHa, H, HOCH2CH2CH2CH2, Cl), (M-5631, F, CHa, H, HOCH2CH2CH2CH2, F), (M-5632, F, CHs, H, HOCH2CH2CH2CH2, CFa), (M-5633, F, CHa, H, HOCH2CH2CH2CH2, Br), (M-5634, F, CH3, H, HOCH2CH2CH2CH2, CHa), (M-5635, F, CHa, H, HOCH2CH2CH2CH2GH2, H), (M-5636, F, CHa, H, HOCH2CH2CH2CH2CH2, Cl), (M-5637, F, CH3, H, HOCH2CH2CH2CH2CH2, F), (M-5638, F, CHs, H, HOCH2CH2CH2CH2CH2, CFa), (M-5639, F, CHa, H, HOCH2CH2CH2CH2CH2, Br), (M-5640, F, CHa, H, HOCH2CH2CH2CH2CH2, CH3), (M-5641, F, CHa, H, HOCH2CH2OCH2CH2, H)t (M-5642, F, CHs, H, HOCH2CH2OCH2CH2, Cl), (M-5643, F, CHa, H, HOCH2CH2OCH2CH2, F), (M-5644, F, CHa, H, HOCH2CH2OCH2CH2, CF3), (M-5645, F, CH3, H, HOCH2CH2OCH2CH2, Br), (M-5646, F, CHa, H, HOCH2CH2OCH2CH2, CHa), (M-5647, F, CHs, H, (Me)2N, Η), (M-5648, F, CH3, 182 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ^___h_____ ---1 — — — — — (請先閱讀背面之注意事項再填寫本頁) lrj_ 1284639 A7 Γ_____Β7___ 五、發明說明（A ) H, (Me)2N, Cl), (M-5649, F, CH3, H, (Me)2N, F), (M-5650, F, CH3, H, (Me)2N, CF3), (M-5651, F, CH3, H, (Me)2N, Br), (M-5652, F, CH3, H, (Me)2N, CH3), (M·5653, F, CH3, H,哌啶-4-基甲基，Η), (M·5654, F, CH3, H,哌啶」 4-基甲基，Cl), (M-5655, F, CH3, H,哌啶-4-基甲基，F), (Μ·5656, F, CH3, H,哌啶-4 -基甲棊 > CF3), (M-5657, F, CH3, H,哌啶-4 -基甲基， Br), (M-5658, F, CH3, H,哌啶-4·基甲棊，CHs)，（M.5659, F, CH3, Η, 環己基甲棊，Η), (M-5660, F, CH3, H,環己基甲基，Cl), (M-5661, F, CH3, H,環己基甲基，F), (M-5662, F, CH3, H,環己基甲基，CF3), (M-5663, F, CH3, H,環己基甲基，Br), (M-5664, F, CH3, H, 經濟部智慧財產局員工消費合作社印製 .丨丨、——卜-------------訂 (請先閱讀背面之注意事項再填寫本頁) 環己基甲基，CH3), (M-5665, F, CH3, F, Η, Η), (M-5666, F, CH3, F, H, Cl), (M-5667, F, CH3, F, H, F), (M-5668, F, CH3, F, H, CF3), (M-5669, F, CH3, F, H， Br), (Μ·5670, F, CH3, F, H, CH3), (M-5671, F, CH3, F, F, Η), (Μ·5672, F, CH3, F, F, Cl), (Μ·5673, F, CH3, F, F, F), (M-5674, F, CH3, F, F, CF3), (M-5675, F，CH3, F, F, Br), (M-5676, F, CH3, F, F, CH3), (M-5677, F, CH3, F, Cl, H>, (Μ·5678, F， CH3,F,C1,C1),(M-5679,F,CH3,F,C1,F),(M-5680,F,CH3,F,C1，CF3),(M· 5681, F, CHa, F, Cl, Br), (M-5682, F, CHa, F, Cl, CHa), (M-5683, F, CHa, F, CH3, Η), (M-5684, F, CH3, F, CH3, Cl), (M-5685, F, CH3, F, CH3, F), (M-5686, F, CH3, F, CH3, CF3), (M-5687, F, CH3, F, CH3, Br), (M-5688, F, CH3, F, CH3, CH3), (M-5689, F, CH3, F, Et, Η), (M-5690, F, CH3, F, Et, Cl), (M-5691, F, CH3, F, Et， F), (M-5692, F, CH3, F, Et, CF3), (M-5693, F，CH3, F，Et, Br)，（M-5694, F，CH3, F,Et,CH3),(M-5695,F,CH3,F,n-Pr,H),(M-5696,F,CH3,F,n-Pr,Cl)，（M· 5697, F, CH3, F, n.Pr, F), (M-5698, F, CH3, F, n-Pr, CF3), (Μ·5699, F, CH3, F， n-Pr, Br), (M-5700, F, CHa, F, n-Pr, CHa), (M-B701, F, CHa, F, c-Pr, Η), (M-5702, F, CHs, F, c-Pr, Cl), (M-5703, F, CHs, F, c-Pr, F), (M-5704, F, CHa, F, c-Pr, CF3), (M-5705, F, CHa, F, c-Pr, Br), (M-5706, F, CHs, F, c-Pr, CHa), (M-5707, F, CH3, F, i-Pr, Η), (M-5708, F, CHa, F, i-Pr, Cl), (M-5709, F, CH3, F, i-Pr, F), (M-5710, 183 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 __B7_____ 五、發明說明（+ ) F, CH3, F, i-Pr, CF3), (M-5711, F, CH3, F, i-Pr, Br), (M-5712, F, CH3, F, i-Pr， CH3), (M-5713, F, CH3, F, n-Bu, Η), (M-5714, F, CH3, F, n-Bu, Cl), (M-5715, F, CH3, F, n-Bu, F), (M-5716, F，CH3, F, n-Bu, CF3), (M-5717, F, CH3, F, n-Bu, Br)， (M-5718, F, CH3, F, n-Bu, CH3), (M-5719, F, CHs, F, i-Bu，Η), (M-5720, F, CH3, F, i-Bu, Cl), (M-6721, F, CH3, F, i-Bu, F), (M-6722, F, GHa, F, i-Bu, CFs), (M-5723, F, CH3, F, i-Bu, Br), (M-5724, F, CHs, F, i-Bu, CHs), (M-5725, F, CHs, F, sec-Bu, Η), (M-5726, F, CH3, F, sec-Bu, Cl), (M-5727, F, CH3, F, sec-Bu, F)， (M-5728, F, CH3, F, sec-Bu, CF3), (M-5729, F, CH3, F, sec-Bu, Br), (M-5730, F, CH3, F, sec-Bu, CH3), (M-5731, F, CH3, F, n-Pen, Η), (M-5732, F，CH3, F，n-Pen， Cl), (M-5733, F, CH3, F, n-Pen, F), (M-5734, F, CH3, F，n-Pen, CF3), (M-5735, F, CH3, F, n-Pen, Br), (M-5736, F，CH3, F, n-Pen, CH3), (M-5737, F, CH3, F, c-Pen, Η), (M-5738, F, CH3, F, c-Pen，Cl), (M-5739, F, CH3, F, c-Pen, F>, (M-5740, F， CH3, F, c-Pen, CF3), (M-5741, F, CH3, F, c-Pen, Br), (M-5742, F, CH3, F, c-Pen, CH3), (M-5743, F, CH3, F, n-Hex, Η), (M-5744, F, CH3, F, n-Hex, Cl), (M-5745, F,CH3,F,n-Hex,F),(M-5746,F,CH3,F,n-Hex,CF3),(M-5747,F，CH3，F，n-Hex, Br), (M-5748, F, CH3, F, n-Hex, CH3), (M-5749, F, CH3, F, c-Hex, H), (M-5750, F, CH3, F, c-Hex, Cl), (M-5751, F, CH3, F, c-Hex, F), (M-5752, F, CH3, F, c-Hex, CF3), (M-5753, F, CH3, F, c-Hex, Br), (M-5754, F, CH3, F, c-Hex，CH3)， (M-5755, F, CH3, F, OH, Η), (M-5756, F, CH3, F, OH, Cl), (M-5757, F, CH3, F， OH, F)，（M-5758, F, CH3, F, OH, CF3), (M-5759, F，CH3, F, OH, Br), (M-5760, F， CH3, F, OH, CH3), (M-5761, F, CH3, F, EtO, Η), (M-5762, F，CH3, F, EtO, Cl)， (M-5763, F, CH3, F, EtO, F)，（M-5764, F, CH3, F, EtO, CF3)，(M-5765, F，CH3, F, EtO,Br),(M-5766,F,CH3,F,EtO,CH3),(M-5767,F,CH3,F，n-PrO，H)，（M-5768, F, CH3, F, n-PrO, Cl)，（M-5769, F, CH3, F, n-PrO, F), (M-5770, F, CH3, F， n-PrO, CF3), (M-5771, F, CH3, F, n-PrO, Br), (M-5772, F, CH3, F, n-PrO, CH3)， (M-5773, F, CH3, F, PhO, H)，（M-5774, F, CH3, F，PhO, Cl), (M-5775, F，CH3, F， 184 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） (請先閱讀背面之注意事項再填寫本頁) ---- 訂----- 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（A)
PhO, F), (M-5776, F, CH3, F, PhO, CF3), (M-5777, F, CH3, F, PhO, Br), (Μ·5778, F, CH3, F, PhO, CHa), (M-5779, F, CHa, F, BnO, Η), (M-5780, F, CHa, F, BnO, Cl), (Μ·5781, F, CH3, F, BnO, F), (M-5782, F, CH3, F, BnO, CF3), (M-5783, F, CH3, F, BnO, Br), (M-5784, F, CH3, F, BnO, CH3)，（M-5785, F, CH3, F， PhCH2CH2〇, Η), (Μ·5786, F, CH3, F, PhCH2CH2〇, Cl), (M-5787, F, CH3, F， PhCH2CH2〇, F), (M-5788, F, CH3, F, PhCH2CH2〇, CF3), (M-5789, F, CH3, F, PhCH2CH2〇, Br), (M-5790, F, CH3, F, PI1CH2CH2O, CH3), (M-5791, F, CH3, F, CF3〇, Η), (M-5792, F, CH3, F, CF3〇, Cl), (M-5793, F, CH3, F, CF3〇, F)，（M-5794, F, CH3, F, CFaO, CF3>, (M-5795, F, CH3, F, CF3〇, Br), (M-5796, F, CH3, F, CF3〇, CH3), (M-5797, F, CH3, F, Ph, Η), (M-5798, F, CH3, F, Ph, Cl), (M-5799, F, CH3, F, Ph, F), (M-5800, F, CH3, F, Ph, CF3), (M-5801, F, CH3, F, Ph, Br), (M-5802, F， CH3, F, Ph, CH3), (M-5803, F, CH3, F, 4-F-Ph, Η), (M-5804, F, CH3, F, 4-F-Ph， Cl), (M-5805, F, CH3, F, 4-F-Ph, F), (M-5806, F, CH3, F, 4-F-Ph, CF3)，（Μ·5807, F, CH3, F, 4-F-Ph, Br), (M-5808, F, CH3, F, 4-F-Ph, CHa), (M-5809, F, CH3, F, 4-CF3-Ph, Η), (M-5810, F, CH3, F, 4-CF3-Ph, Cl), (M-5811, F, CH3, F, 4-CF3-Ph, F), (M-5812, F, CH3, F, 4-CF3-Ph, CF3), (M-5813, F, CH3, F, 4-CF3-Ph, Br), (M-5814, F, CH3, F, 4-CF3-Ph, CH3), (M-5815, F, CH3, F, 4-(Me)2N-Ph，H), (M-5816, F, CH3, F, 4-(Me)2N-Ph, Cl), (M-5817, F, CH3, F, 4-(Me)2N-Ph, F), (M-5818, F, CH3, F, 4-(Me)2N-Ph，CF3), (M-5819, F, CH3, F, 4-(Me)2N-Ph, Br)， (M-5820, F, CH3, F, 4-(Me)2N-Ph, CH3), (M-5821, F, CH3, F, 4-OH-Ph, Η), (M-5822, F, CH3, F, 4-OH-Ph, Cl), (M-5823, F, CH3, F, 4-OH-Ph, F), (M-5824, F， CH3, F, 4-OH-Ph, CF3), (M-5825, F, CH3, F, 4-OH-Ph, Br), (M-5826, F, CH3, F， 4-OH-Ph, CHs), (M-5827, F, CH3, F, 3,4-di-F-Ph, Η), (M-5828, F, CH3, F, 3,4-di-F-Ph, Cl), (M-5829, F, CH3, F, 3,4-di.F-Ph, F), (M-5830, F, CH3, F, 3,4-di-F-Ph, CFa), (M-5831, F, CH3, F, 3,4-di-F.Ph, Br), (M-5832, F, CHa, F, 3,4-di-F-Ph, CH3), (M-5833, F, CH3, F, 4-COOH-Ph, Η), (M-5834, F, CH3, F, 4- 185 ^紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ! ! *——U.-------------訂 (請先閱讀背面之注意事項再填寫本頁) — — — — — — — I — 1284639 A7 B7 五、發明說明（，） COOH-Ph, Cl), (M-5835, F, CHs, F, 4-COOH-Ph, F), (M-5836, F, CHa, F, 4-COOH-Ph, CFa), (M-5837, F, CHs, F, 4-COOH-Ph, Br), (M-5838, F, CHs, F, 4-COOH-Ph, CH3), (M-5839, F, CHs, F, Bn, Η), (M-5840, F, CH3, F, Bn, Cl), (M- 5841, F, CH3, F, Bn, F), (Μ·5842, F, CH3, F, Bn, CF3), (M-5843, F, CH3, F, Bn. Br), (M-5844, F, CH3, F, Bn, CH3), (M-5845, F, CH3, F, 4-F-Bn, Η), (M-5846, F， CH3，F,4-F-Bn,Cl),(M-5847,F,CH3,F,4-F-Bn,F)，（M-5848,F,CH3,F,4-F· Bn, CF3), (M-5849, F, CH3, F, 4-F-Bn, Br), (M-5850, F, CH3, F, 4-F-Bn, CH3)， (M-5851, F, CH3, F, 2-Py, Η), (M-5852, F, CH3, F, 2-Py, Cl), (M-5853, F，CH3, F， 2-Py, F), (M-5854, F, CH3, F, 2-Py, CF3), (M-5855, F, CH3, F, 2-Py, Br), (M-585G， F, CH3, F, 2-Py, CH3), (M-5857, F, CH3, F, 3-Py, Η), (M-5858, F, CH3, F，3-Py, Cl), (M-5859, F, CH3, F, 3-Py, F), (M-5860, F, CH3, F, 3-Py, CF3)，（M-5861, F， CH3, F, 3-Py, Br), (M-5862, F, CH3, F, 3-Py, CH3), (M-5863, F, CH3, F, 4-Py, H)， (M-5864, F, CH3, F, 4-Py, Cl), (M-5865, F, CH3, F, 4-Py, F), (M-5866, F，CH3, F， 4-Py,CF3),(M-5867,F,CH3,F,4-Py,Br),(M-5868,F,CH3,F，4-Py,CH3)，（M-5869, F, CH3, F, 2-Th, Η), (M-5870, F, CH3, F, 2-Th, Cl), (M-5871, F, CHa, F， 2-Th, F), (M-5872, F, CH3, F, 2-Th, CF3), (M-5873, F, CH3, F, 2-Th, Br), (M-5874, F, CH3, F, 2-Th, CH3), (M-5875, F, CH3, F, 3-Th, Η), (M-5876, F, CH3, F，3-Th， Cl), (M-5877, F, CH3, F, 3-Th, F), (M_5878, F, CH3, F, 3-Th, CF3), (M-5879, F， CH3, F, 3-Th, Br), (M-5880, F, CH3, F, 3-Th, CH3), (M-5881，F, CH3, F, 吡唑-2-基，Η), (M-5882, F, CH3, F,吡唑-2-基· Cl), (M-5883, F, CH3, F， 吡唑-2-基，F), (M-5884, F, CH3, F,吡唑-2-基，CF3), (M-5885, F, CH3, F, 吡唑-2-基，,Br), (M-5886, F, CH3, F,吡唑·2-基，CH3), (M-5887, F, CH3, F， 吡唑-3 -基，，Η), (M-5888, F, CH3, F,吡唑·3 -棊,Cl), (M-5889, F, CH3, F， 吡唑-3-基，F), (M-5890, F, CH3, F,吡唑-3-基，CF3)，（M-5891, F, CH3, F， 吡唑· 3 -基，Br), (M-5892, F, CH3, F,吡唑-3 -基· CH3), (Μ·5893, F, CH3, F, 嘧啶-2 -基，Η), (M-5894, F, CH3, F,嘧啶-2 -基，Cl), (M-5895, F, CH3, F, 186 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） __^____一_____ — — — — — — — — (請先閱讀背面之注意事項再填寫本頁) 訂· — 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、發明說明（π) 嘧啶-2-基，F), (M_6896, F, CH3, F,嘧啶基,，CF3)，（Μ-5897, F，CH3, F,嘧啶-2-基，Br), (M-5898, F, CH3, F,嘧啶-2-基，CH3), (M-5899, F, CH3, F,嘧啶-4 _ 基，Η), (M-5900, F, CH3, F,嘧啶-4 -基，Cl), (M-5901, F， CH3, F,嘧啶-4-棊，F), (M-5902, F, CH3, F,嘧啶-4-基，CF；〇,（M.6903· F, CH3, F,嘧啶-4-棊1, Br), (M-5904, F, CH3, F,嘧啶-4-基，CH3), (M. 5905, F, CH3, F,嘧啶-5-基，Η), (Μ·5906, F, CH3, F, _ 啶-5·基，Cl), (M-5907, F, CH3, F, p嘧啶-5-基.，F), (M-5908, F, CH3, F, F嘧啶·5-基， CF3), (Μ·5909, F, CH3, F,嘧啶-5-基，Br), (M-5910, F, CH3, F,嘧啶-5· 基，CH3), (Μ·5911, F, CH3, F, HOOCCH2CH2CH2, Η), (M-5912, F, CH3, F， HOOCCH2CH2CH2, Cl), (M-5913, F, CHs, F, HOOCCH2CH2CH2, F), (M-5914, F, CH3, F, HOOCCH2CH2CH2, CFs), (M-5915, F, CH3, F, HOOCCH2CH2CH2, Br), (M-5916, F, CHa, F, HOOCCH2CH2CH2, CHs), (M-5917, F, CH3, F, HOOCCH2CH2CH2CH2, Η), (M-5918, F, CHa, F, HOOCCH2CH2CH2CH2, Cl), (M-5919, F, CH3, F, HOOCCH2CH2CH2CH2, F), (M-5920, F, CH3, F, HOOCCH2CH2CH2CH2, CF3), (M-5921, F, CH3, F, HOOCCH2CH2CH2CH2, Br), (M-5922, F, CHa, F, HOOCCH2CH2CH2CH2, CHa), (M-5923, F, CHa, F, (Me)2NCOCH2CH2CH2CH2, Η), (M-5924, F, CH3, F, (Me)2NCOCH2CH2CH2CH2, Cl), (M-5925, F, CH3, F, (Me)2NCOCH2CH2CH2CH2, F), (M-5926, F, CH3, F， (Me)2NCOCH2CH2CH2CH2, CF3), (M-5927, F，CH3, F, (Me)2NCOCH2CH2CH2CH2, Br), (M-5928, F, CH3, F, (Me)2NCOCH2CH2CH2CH2, CH3), (M-5929, F, CH3, F, (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-5930, F, CH3, F, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-5931, F, CHa, F, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-5932, F, CH3, F, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-5933, F, CH3, F, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-5934, F, CHa, F, 187 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公爱） 4^4 (請先閱讀背面之注意事項再填寫本頁) 訂--- 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、發明說明（、〜） (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-5935, F, CH3, F, MeOCH2, Η), (M· 5936, F, CHa, F, MeOCH2, Cl), (M-5937, F, CH3, F, MeOCH2, F), (M-5938, F, CH3, F, MeOCH2, CFs), (M-5939, F, CHs, F, MeOCH2, Br), (M-5940, F, CH3, F, MeOCH2, CHa), (M-5941, F, CHa, F, EtOCH2, Η), (M-5942, F, CHa, F, EtOCH2, Cl), (M-5943, F, CHs, F, EtOCH2, F), (M-5944, F, CHs, F, EtOCH2, CFa), (M-5945, F, CHa, F, EtOCH2, Br), (M-5946, F, CHa, F, EtOCH2, CH3), (M-5947, F, CH3, F, EtOCH2CH2, Η), (M-5948, F, CHa, F, EtOCH2CH2, Cl), (M-5949, F, CH3, F, EtOCH2CH2, F), (M-5950, F, CH3, F, EtOCH2CH2, CF3), (M-5951, F, CH3, F， EtOCH2CH2, Br), (M-5952, F, CH3, F, EtOCH2CH2, CH3), (M-5953, F, CH3, F， MeOCH2CH2OCH2CH2, H>, (M-5954, F, CH3, F, MeOCH2CH2〇CH2CH2, Cl)， (M-5955, F, CH3, F, MeOCH2CH2〇CH2CH2, F), (M-5956, F, CH3, F, MeOCH2CH2〇CH2CH2, CF3), (Μ·5957, F, CH3, F, MeOCH2CH2〇CH2CH2, Br)， (M-5958, F, CH3, F, MeOCH2CH2〇CH2CH2, CH3), (M-5959, F，CH3, F， MeOCH2CH2, Η), (M-5960, F, CH3, F, MeOCH2CH2, Cl), (M-5961, F, CH3, F， MeOCH2CH2, F), (M-5962, F, CH3, F, MeOCH2CH2, CF3), (M-5963, F, CH3, F， MeOCH2CH2, Br), (M-5964, F, CH3, F, MeOCH2CH2, CH3), (M-5965, F, CH3, F, HOCH2, Η), (M-5966, F, CH3, F, HOCH2, Cl), (M-5967, F, CH3, F，HOCH2, F)， (M-5968, F，CH3, F, HOCH2, CF3), (M-5969, F, CH3, F, HOCH2, Br), (M-5970, F， CH3, F, HOCH2, CH3), (M-5971，F, CH3, F, HOCH2CH2, Η), (M-5972, F, CH3, F， HOCH2CH2, Cl), (M-5973, F, CHa, F, HOCH2CH2, F), (M-5974, F, CHa, F, HOCH2CH2, CFa), (M-5975, F, CH3, F, HOCH2CH2, Br), (M-5976, F, CHa, F, HOCH2CH2, CHa), (M-5977, F, CHs, F, HOCH2CH2CH2, Η), (M-5978, F, CHa, F, HOCH2CH2CH2, Cl), (M-5979, F, CHa, F, HOCH2CH2CH2, F), (M-5980, F, CHa, F, HOCH2CH2CH2, CFs), (M-5981, F, CHs, F, HOCH2CH2CH2, Br), (M-5982, F, CH3, F, HOCH2CH2CH2, CH3), (M-5983, F, CH3, F, HOCH2CH2CH2CH2, H), (M-5984, F, CHa, F, HOCH2CH2CH2CH2, Cl), (M-5985, F, CHa, F, 188 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） .— -ί——l·----- (請先閱讀背面之注意事項再填寫本頁) 訂i 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 _B7_ .__ 五、發明說明（lW) HOCH2CH2CH2CH2, F), (M-5986, F, CHa, F, HOCH2CH2CH2CH2, CF3), (Μ-5987, F, CHa, F, HOCH2CH2CH2CH2, Br), (M-5988, F, CH3, F, HOCH2CH2CH2CH2, CHs), (M-5989, F, CHa, F, HOCH2CH2CH2CH2CH2, H), (M-5990, F, CH3, F, HOCH2CH2CH2CH2CH2, Cl), (M-5991, F, CH3, F, HOCH2CH2CH2CH2CH2, F), (M-6992, F, CHa, F, HOCH2CH2CII2CH2CH2, CFs), (M-5993, F, CH3, F, HOCH2CH2CH2CH2CH2, Br), (M-5994, F, CHa, F, HOCH2CH2CH2CH2CH2, CHa), (M-5995, F, CH3, F, HOCH2CH2OCH2CH2, H), (M-5996, F, CHa, F, HOCH2CH2OCH2CH2, Cl), (M-5997, F, CHa, F, HOCH2CH2OCH2CH2, F), (M-5998, F, CHa, F, HOCH2CH2OCH2CH2, CF3), (M-5999, F, CH3, F, HOCH2CH2OCH2CH2, Br), (M-6000, F, CH3, F, HOCH2CH2OCH2CH2, CHs), (M-6001, F, CHs, F, (Me)2N, Η), (M-6002, F, CHs, F, (Me)2N, Cl), (M-6003, F, CH3, F, (Me)2N, F), (M-6004, F, CH3, F, (Me)2N， CF3), (M-6005, F, CH3, F, (Me)2N, Br), (M-6006, F, CH3, F, (Me)2N, CH3), (M· 6007, F, CH3, F,哌啶-4 基甲基，Η), (M-6008, F, CH3, F,哌啶-4 -基甲基，Cl), (Μ·6009, F, CH3, F,哌啶-4 -基甲基，F), (M-6010, F, CH3, F,哌啶-4 -基甲基，CF3), (M-6〇ll, F, CH3, F,哌啶· 4 -基甲基· Br), (M-6012, F, CH3, F,哌啶-4-基甲基，CH3), (M-6013, F, CH3, F, 環己基甲基I, Η), (M-6014, F, CH3, F,環己基甲基 Cl), (M-6015, F, CH3, F, < 環己基甲基，F), (M-6016, F, CH3, F,環己基甲基，CF3)， (Μ·6017, F, CH3, F,環己基甲基，,Br), (M-6018, F, CH3, F, 環己基甲基，QH3), (M-6019, F, CH3, Cl, Η, Η), (M-6020, F, CH3, Cl, H, Cl)， (M-6021, F, CH3, Cl, H, F), (M-6022, F, CH3, Cl, H, CF3), (M-6023, F, CH3, Cl, H， Br), (M-6024, F, CH3, Cl, H, CH3), (M-6025, F, CH3, Cl, F, Η), (M-6026, F，CH3, Cl，F, Cl), (M-6027, F, CH3, Cl, F, F), (M-6028, F, CH3, Cl, F, CF3), (M-6029, F, CH3, Cl, F, Br), (M-6030, F, CH3, Cl, F, CH3), (M-6031, F, CH3, Cl, Cl, H)， (M-6032, F, CH3, Cl, Cl, Cl), (M-6033, F, CH3, Cl, Cl, F), (M-6034, F, CH3, Cl，Cl， 189 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ---^----1--------- ----訂----- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五、發明說明（I Μ) CFs), (M-6035, F, CHs, Cl, Cl, Br), (M-6036, F, CHa, Cl, Cl, CHa), (M-6037, F, CH3, Cl, CH3, Η), (M-6038, F, CH3, Cl, CH3, Cl), (M-6039, F, CH3, Cl, CH3, F), (M-6040, F, CH3, Cl, CH3, CF3), (M-6041, F, CH3, Cl, CH3, Br), (M-6042, F，CH3, Cl, CH3, CHa), (M-6043, F, CH3, Cl, Et, Η), (M-6044, F，CH3, Cl, Et, Cl), (M· 6045, F, CHa, Cl, Et, F), (M-6046, F, CHa, Cl, Et, CFa), (M-6047, F, CHa, Cl, Et, Br), (M-6048, F, CH3, Cl, Et, CHs), (M-6049, F, CH3, Cl, n-Pr, H)，（M-6050, F， CH3, Cl, n-Pr, Cl), (M-6051, F, CHs, Cl, n-Pr, F), (M-6052, F, CH3, Cl, n-Pr, CF3), (M-6053, F, CH3, Cl, n-Pr, Br), (M-6054, F, CH3, Cl, n-Pr, CH3), (M-6055, F, CH3, Cl, c-Pr, Η), (M-6056, F, CHa, Cl, c-Pr, Cl), (M-6057, F, CH3, Cl, c-Pr, F), (M-6058, F, CH3, Cl, c-Pr, CF3), (M-6059, F, CH3, Cl, c-Pr, Br)，（M-6060, F, CH3, Cl, c-Pr, CHa), (M-6061, F, CHs, Cl, i-Pr, Η), (M-6062, F, CHa, Cl, i-Pr, Cl), (M-6063, F, CH3, Cl, i-Pr, F), (M-6064, F, CH3, Cl, i-Pr, CF3)，（M-6065, F, CH3, Cl, i-Pr, Br), (Μ·6066, F, CH3, Cl, i-Pr, CH3), (M-6067, F, CH3, Cl，n-Bu, H>, (M-6068, F, CH3, Cl, n-Bu, Cl), (M-6069, F, CH3, Cl, n-Bu, F), (M-6070, F, CH3, Cl, n-Bu, CF3), (M-6071, F, CH3, Cl, n-Bu, Br), (M-6072, F, CH3, Cl, n-Bu, CH3), (M-6073, F, CH3, Cl, i-Bu, Η), (M-6074, F, CH3, Cl, i-Bu，Cl), (M-6075, F, CH3, Cl, i-Bu, F), (M-6076, F, CH3, Cl, i-Bu, CF3), (M-6077, F, CH3, Cl, i-Bu, Br)， (M-6078, F, CHs, Cl, i-Bu, CH3), (M-6079, F, CHa, Cl, sec-Bu, Η), (M-6080, F, CH3, Cl, sec-Bu, Cl), (M-6081, F, CH3, Cl, sec-Bu, F), (M-6082, F, CH3, Cl, gec-Bu, CF3), (M-6083, F, CHs, Cl, sec-Bu, Br), (M-6084, F, CHs, Gl, sec-Bu, CH3), (M-6085, F, CH3, Cl, n-Pen, Η), (M-6086, F, CH3, Cl, n-Pen, Cl), (M-6087, F, CH3, Cl, n-Pen, F), (M-6088, F, CH3, Cl, n-Pen, CF3), (M-6089, F, CH3, Cl， n-Pen, Br), (M-6090, F, CH3, Cl, n-Pen, CH3), (M-6091, F, CH3, Cl, c-Pen，H)， (M-6092, F, CH3, Cl, c-Pen, Cl), (M-6093, F, CH3, Cl, c-Pen, F)，（M-6094, F，CH3, Cl, c-Pen, CF3), (M-6095, F, CH3, Cl, c-Pen, Br), (M-6096, F，CH3, Cl, c-Pen, CHs), (M-6097, F, CH3, Cl, n-Hex, Η), (M-6098, F, CH3, Cl, n-Hex, Cl), (M-G099, 190 i紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公' ： ——·1 ——·_----- (請先閱讀背面之注意事項再填寫本頁) 訂· — 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、發明說明（I 〇) F, CHa, Cl, n-Hex, F), (M-6100, F, CHs, Cl, n-Hex, CFs), (M-6101, F, CHa, Cl, n-Hex, Br), (M-6102, F, CHa, Cl, n-Hex, CHa), (M-6103, F, CH3, Cl, c-Hex, H), (M-6104, F, CH3, Cl, c-Hex, Cl), (M-6105, F, CH3, Cl, c-Hex, F), (M-6106, F, CH3, Cl, c-Hex, CF3), (M-6107, F, CH3, Cl, c-Hex, Br>, (M-6108, F, CH3, Cl, c-Hex· CHa), (M-6109, F, CHa, Cl, OH, Η), (M-6110, F, GHa, Cl, OH, Cl), (M-6111, F, CH3, Cl, OH, F), (M-6112, F, CHa, Cl, OH, CF3), (M-6113, F, CHs, Cl, OH, Br), (M-6114, F, CH3, Cl, OH, CH3), (M-6115, F, CH3, Cl, EtO, Η), (M-6116, F, CH3, Cl, EtO, Cl), (M-6117, F, CHa, Cl, EtO, F), (M-6118, F, CHa, Cl, EtO, CFs), (M-6119, F, CH3, Cl, EtO, Br), (M-6120, F, CH3, Cl, EtO, CH3), (M-6121，F，Cil3, Cl, n-PrO, Η), (M-6122, F, CH3, Cl, n-PrO, Cl), (M-6123, F, CH3, Cl, n-PrO, F)， (M-6124, F, CH3, Cl, n-PrO, CF3), (M-6125, F, CH3, Cl, n-PrO, Br), (M-6126, F， CH3, Cl, n-PrO, CH3), (M-6127, F, CH3, Cl, PhO, Η), (M-6128, F, CH3, Cl, PhO, Cl), (M-6129, F, CH3, Cl, PhO, F), (M-6130, F, CH3, Cl, PhO, CF3), (M-6131, F， CHs, Cl, PhO, Br), (M-6132, F, CH3, Cl, PhO, CH3), (M-6133, F, GHs, Cl, BnO, Η), (M-6134, F, CH3, Cl, BnO, Cl), (M-6135, F, CH3, Cl, BnO, F), (M-6136, F, CH3, Cl, BnO, CF3), (M-6137, F, CH3, Cl, BnO, Br), (M-6138, F, CH3, Cl，BnO, CHs), (M-6139, F, CHs, Cl, PhCH2CH20, Η), (M-6140, F, CHa, Cl, PhCH2CH2〇> Cl), (M-6141, F, CH3, Cl, PhCH2CH2〇, F), (M-6142, F, CH3, Cl, PhCH2CH2〇, CFa), (M-6143, F, CHa, Cl, PhCH2CH2〇, Br), (M-6144, F, CH3, Cl, PhCH2CH2〇, CH3), (M-6145, F, CH3, Cl, CF3〇, Η), (M-6146, F，CH3, Cl, CF3O, Cl), (M-6147、 F, CH3, Cl, CF3〇, F), (M-6148, F, CH3, Cl, CF3〇, CF3), (M-6149, F, CH3, Cl, CF3〇fBr),(M-6150,F,CH3,Cl,CF3〇,CH3),(M-6151,F,CH3，Cl，Ph,H),(M-6152, F, CH3, Cl, Ph, Cl), (M-6153, F, CH3, Cl, Ph, F), (M-6154, F, CH3, Cl, Ph, CF3), (M-6155, F, CH3, Cl, Ph，Br), (M-6156, F, CH3, Cl, Ph, CH3), (Μ·6157, F, CH3, Cl, 4-F-Ph, Η), (M-6158, F, CHa, Cl, 4-F-Ph, Cl), (M-6159, F, CHa, Cl, 4-F-Ph, F), (M-6160, F, CH3, Cl, 4-F-Ph, CF3), (M-6161, F, CH3, Cl, 4-F-Ph, Br), 191 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） — I:——l·----- (請先閱讀背面之注意事項再填寫本頁) 訂1 經濟部智慧財產局員工消費合作社印製 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（l?o (M-6162, F, CH3, Cl, 4-F-Ph, CH3), (M-6163, F, CH3, Cl, 4-CF3-Ph，Η), (M-6164, F, CH3, Cl, 4-CF3-Ph, Cl), (M-6165, F, CH3, Cl, 4-CF3-Ph, F), (M-6166, F, CH3, Cl, 4-CF3-Ph, CFa), (M-6167, F, CHa, Cl, 4-CF3-Ph, Br), (M-6168, F, CHa, Cl, 4-CF3-Ph, CH3), (M-6169, F，CH3, Cl, 4-(Me)2N-Ph，Η), (Μ·6170, F, CH3, Cl, 4.(Me)2N-Ph, Cl), (M-6171, F, CHa, Cl, 4-(Me)2N-Ph, F), (M-6172, F, CHa, Cl, 4-(Me)2N-Ph, CFs), (M-6173, F, CHa, Cl, 4-(Me)2N-Ph, Br), (M-6174, F, CHa, Cl, 4-(Me)2N.Ph, CHa), (M-6175, F, CH3, Cl, 4-OH-Ph, Η), (M-6176, F, CHa, Cl, 4-OH-Ph, Cl), (M-6177, F, CH3, Cl, 4-OH-Ph, F), (M-6178, F, CH3, Cl, 4-OH-Ph， CF3), (M-6179, F, CH3, Cl, 4-OH-Ph, Br), (M-6180, F, CH3, Cl，4-OH-Ph, CHa), (M-6181, F, CH3, Cl, 3,4-di-F-Ph, Η), (M-6182, F, CH3, Cl, 3,4-di-F-Ph, Cl), (M-6183, F, CH3, Cl, 3,4-di-F-Ph, F), (M-6184, F, CH3, Cl, 3,4-di-F-Ph, CF3), (M-6185, F, CH3, Cl, 3,4-di-F-Ph, Br), (M-6186, F, CH3, Cl, 3,4-di-F-Ph, CH3), (M-6187, F, CH3, Cl, 4-COOH-Ph, Η), (M-6188, F, CH3, Cl, 4-COOH-Ph, Cl>, (M-6189, F, CH3, Cl, 4-COOH-Ph, F), (Μ·6190, F, CH3, Cl, 4-COOH-Ph, CF3), (M-6191, F, CH3, Cl, 4-COOH-Ph, Br), (M-6192, F, CH3, Cl, 4-COOH-Ph, CH3), (M-6193, F, CHa, Cl, Bn, Η), (M-6194, F, CHa, Cl, Bn, Cl), (M-6195, F, CHa, Cl, Bn，F), (M-6196, F, CH3, Cl, Bn, CF3), (M-6197, F, CH3, Cl, Bn, Br), (M-6198, F， CH3, Cl, Bn, CHa), (M-6199, F, CH3, Cl, 4-F-Bn, Η), (M-6200, F, CH3, Cl, 4-F-Bn, Cl), (M-6201, F, CH3, Cl, 4-F-Bn, F), (M-6202, F, CH3, Cl, 4-F-Bn, CF3)， (M-6203, F, CH3, Cl, 4-F-Bn, Br), (M-6204, F, CH3, Cl, 4-F-Bn，CH3)，（M-6205, F, CH3, Cl, 2-Py, Η), (M-6206, F, CH3, Cl, 2-Py, Cl>, (M-6207, F，CH3, Cl, 2-Py， F), (M-6208, F, CH3, Cl, 2-Py, CF3), (M-6209, F, CH3, Cl, 2-Py，Br), (Μ·6210, F, CH3, Cl, 2-Py, CH3), (M-6211, F, CH3, Cl, 3-Py, Η), (M-6212, F, CH3, Cl, 3-Py， Cl), (M-6213, F, CH3, Cl, 3-Py, F), (M-6214, F, CH3, Cl, 3-Py, CF3), (M-6215, F， CH3, Cl, 3-Py, Br), (M-6216, F, CH3, Cl, 3-Py, CH3), (M-6217, F，CH3, Cl, 4-Py， Η), (M-6218, F, CH3, Cl，4-Py, Cl), (M-6219, F, CH3, Cl, 4-Py, F), (M-6220, F， 192 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ---.0----r--------- (請先閱讀背面之注意事項再填寫本頁)
訂-I # A7 1284639 -------B7____ 五、發明說明（…） CHa, Cl, 4-Py, CFs), (M-6221, F, CH3, Cl, 4-Py, Br), (M-6222, F, CHs, Cl, 4-Py, CH3), (M-6223, F, CH3, Cl, 2-Th, Η), (M-6224, F, CH3, Cl, 2-Th, Cl), (M-6225, F， CH3, Cl, 2·Τ1ι, F), (M-6226, F, CH3, Cl, 2-Th, CF3), (Μ·6227, F, CH3, Cl, 2-Th， Br), (M-6228, F, CH3, Cl, 2-Th, CH3), (M-6229, F, CH3, Cl，3-Th, Η), (M-6230, F， CH3, Cl, 3-Th, Cl), (M-6231, F, CHs, Cl, 3-Th, F), (M-6232, F, Clh, Cl, 3-Th, CF3), (M-6233, F, CHa, Cl, 3-Th, Br), (M-6234, F, CHa, Cl, 3-Th, CHa), (M-6235, F, CH3, Cl,吡唑-2-基，Η), (M-6236, F, CH3, Cl,吡唑-2-基，Cl), (M-6237, F，CH3, Cl,吡唑-2-基，F), (M-6238, F, CH3, Cl,吡唑-2-基，CF3), (M-6239, F, CH3, Cl,吡唑-2-基，Br), (M-6240, F, CH3, Cl,吡唑-2-基,CH3), (M-6241, F, CH3, Cl,吡唑-3-基，H)，（M-6242, F, CH3, Cl,:吡唑·3-基，Cl)， (M-6243, F, CH3, Cl,吡唑-3 -基，F), (M-6244, F, CH3, Cl,吡唑-3 -基* CF3)， (M-6245, F, CH3, Cl,吡唑-3-基，Br), (M-6246, F, CH3, Cl,吡唑-3-基丨， CH3), (M-6247, F, CH3, Cl,嘧啶-2 -基1, Η), (M-6248, F, CH3, Cl， 嘧啶-2_基小 Cl), (M-6249, F, CH3, Cl,嘧啶-2-基，F), (M-6250, F, CH3, C1,嘧啶-2·基 l, CF3), (M-6251, F, CH3, Cl,嘧啶-2-基 l,Br)，（M-6252，F， CH3, Cl,嘧啶-2-基，CH3), (M-6253, F, CH3, Cl,嘧啶-4-基，Η), (M-6254, F, CH3, Cl,嘧啶-4-基 1, Cl), (M-6255, F, CH3, Cl,嘧啶-4-基，F), (M-6256, F, CH3, Cl,嘧啶-4·基 l, CF3), (M-6257, F, CH3, Cl,嘧啶-4-基， Br), (M-6258, F, CH3, Cl,嘧啶-4-基，CH3), (M-6259, F，CH3, Cl， 靖啶-5-基, H)，（M-6260, F, CH3, Cl,嘧啶-5-基 1，Cl), (M-6261, F, CH3, Cl, !嘧啶-5-基 1, F), (M-6262, F, CH3, Cl,嘧啶-5-基，CF3)，（Μ·6263, F， CH3, Cl，嘧啶-5-基，Br), (M-6264, F, CH3, Cl,嘧啶-5-基，（^3)，（]^-6265, F, CH3, Cl, HOOCCH2CH2CH2, Η), (M-6266, F, CHa, Cl, HOOCCH2CH2CH2, Cl), (M-6267, F, CHa, Cl, HOOCCH2CH2CH2, F), (M-6268, F, CH3, Cl, HOOCCH2CH2CH2, CFa), (M-6269, F, CHa, Cl, HOOCCH2CH2CH2, Br), (M-6270, F, CHa, Cl, HOOCCH2CH2CH2, CHa), (M-6271, F, CHa, Cl, 193 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --.0-----------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 at __ B7 五、發明說明（ιγ) HOOCCH2CH2CH2CH2, Η), (M-6272, F, CHa, Cl, HOOCCH2CH2CH2CH2, Cl), (M-6273, F, CHa, Cl, HOOCCH2CH2CH2CH2, F), (M-6274, F, CHa, Cl, HOOCCH2CH2CH2CH2, CFa), (M-6275, F, CH3, Cl, HOOCCH2CH2CH2CH2, Br), (M-6276, F, CHs, Cl, HOOCCH2CH2CH2CH2, CH3), (M-6277, F, CH3, Cl (Me)2NCOCH2CH2CH2CH2, Η), (M-6278, F, CH3, Cl, (Me)2NCOCH2CH2CH2CH2, Cl), (M-6279, F, CH3, Cl, (Me)2NCOCH2CH2CH2CH2, F), (M-6280, F, CH3, Cl, (Me)2NCOCH2CH2CH2CH2, CF3), (M-6281, F, CH3, Cl, (Me)2NCOCH2CH2CH2CH2, Br), (M-6282, F，CH3, Cl， (Me)2NCOCH2CH2CH2CH2, CH3), (Μ·6283, F, CH3, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-6284, F, CHa, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-6285, F, CH3, Cl, (Me)2NCOCH2CH2CH2CH2CH2, F)，（M-6286, F, CH3, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-6287, F, CH3, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-6288, F, CH3, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-6289, F, CHa, Cl, MeOCH2, H)，（M· 6290, F, CH3, Cl, MeOCH2, Cl), (M-6291, F, CH3, Cl, MeOCH2, F), (M-6292, F, CHa, Cl, MeOCH2, CFs), (M-6293, F, CHa, Cl, MeOCH2, Br), (M-6294, F, CH3, Cl, MeOCH2, CH3), (M-6295, F, CH3, Cl, EtOCH2, Η), (M-6296, F, CH3, Cl, EtOCH2, Cl), (M-6297, F, CH3, Cl, EtOCH2, F), (M-6298, F，CH3, Cl, EtOCH2, CF3), (M-6299, F, CHa, Cl, EtOCH2, Br), (M-6300, F, CH3, Cl, EtOCH2, CHa), (M-6301, F, CH3, Cl, EtOCH2CH2, Η), (M-6302, F, CH3, Cl, EtOCH2CH2, Cl), (M-6303, F， CH3, Cl, EtOCH2CH2, F), (M-6304, F, CH3, Cl, EtOCH2CH2, CF3>，（M-6305, F， CH3, Cl, EtOCH2CH2, Br), (M-6306, F, CH3, Cl, EtOCH2CH2, CH3)，（M-6307, F， CH3, Cl, MeOCH2CH2〇CH2CH2, Η), (M-6308, F, CH3, Cl, MeOCH2CH2〇CH2CH2, Cl), (M-6309, F, CH3, Cl, MeOCH2CH2〇CH2CH2, F)， (M-6310, F, CH3, Cl, MeOCH2CH2〇CH2CH2, CF3), (M-6311，F, CH3, Cl， 194 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） •丨 I:——l·----- (請先閱讀背面之注意事項再填寫本頁) 訂丨 經濟部智慧財產局員工消費合作社印製 /1284639 經濟部智慧財產局員工消費合作社印製 A7 __B7_______ 五、發明說明（Μ)
MeOCH2CH2〇CH2CH2, Br), (M-6312, F, CH3, Cl, MeOCH2CH2〇CH2CH2, CHa), (M-6313, F, CHa, Cl, MeOCH2CH2, Η), (M-6314, F, CHa, Cl, MeOCH2CH2, Cl), (M-6315, F, CH3, Cl, MeOCH2CH2, F), (M-6316, F, CH3, Cl, MeOCH2CH2, CF3), (M-6317, F, CH3, Cl, MeOCH2CH2, Br), (M-6318, F, CH8, Cl, MeOCH2CH2, CH3), (M-6319, F, CHa, Cl, HOCH2, Η), (M-6320, F, CH3, Cl, HOCII2, Cl), (M-6321, F, CHa, Cl, HOCH2, F), (M-6322, F, CH3, Cl, HOCH2, CFa), (M-6323, F, CH3> Cl, HOCH2, Br), (M-6324, F, CHs, Cl, HOCH2, CH3), (M-6325, F, CH3, Cl, HOCH2CH2, Η), (M-6326, F, CH3, Cl, HOCH2CH2, Cl), (M-6327, F，CH3, Cl, HOCH2CH2, F), (M-6328, F, CH3, Cl, HOCH2CH2, CF3), (M-6329, F, CH3, Cl, HOCH2CH2, Br), (M-6330, F, CHs, Cl, HOCH2CH2, CH3), (M-6331, F, CHa, Cl, HOCH2CH2CH2, Η), (M-6332, F, CHa, Cl, HOCH2CH2CH2, Cl), (M-6333, F, CH3, Cl, HOCH2CH2CH2, F), (M-6334, F, CHa, Cl, HOCH2CH2CH2, CF3), (M-6335, F, CHa, Cl, HOCH2CH2CH2, Br), (M-6336, F, CHa, Cl, HOCH2CH2CH2, CH3), (M-6337, F, CHa, Cl, HOCH2CH2CH2CH2, Η), (M-6338, F, CH3, Cl, HOCH2CH2CH2CH2, Cl), (M-6339, F, CH3, Cl, HOCH2CH2CH2CH2, F), (M-6340, F, CHs, Cl, HOCH2CH2CH2CH2, CFs), (M-6341, F, CHs, Cl, HOCH2CH2CH2CH2, Br), (M-6342, F, CHa, Cl, HOCH2CH2CH2CH2, CHa), (M-6343, F, CHa, Cl, HOCH2CH2CH2CH2CH2, Η), (M-6344, F, CHa, Cl, HOCH2CH2CH2CH2CH2, Cl), (M-6345, F, CH3, Cl, HOCH2CH2CH2CH2CH2, F), (M-6346, F, CHa, Cl, HOCH2CH2CH2CH2CH2, CFa), (M-6347, F, CHs, Cl, HOCH2CH2CH2CH2CH2, Br), (M-6348, F, CHs, Cl, HOCH2CH2CH2CH2CH2, CHs), (M-6349, F, CHs, Cl, HOCH2CH2OCH2CH2, Η), (M-6350, F, CHs, Cl, HOCH2CH2OCH2CH2, Cl), (M-6351, F, CH3, Cl, H0CH2CH20C1I2CH2, F), (M-6352, F, CHs, Cl, HOCH2CH2OCH2CH2, CFa), (M-6353, F, CHa, Cl, HOCH2CH2OCH2CH2, Br), (M-6354, F, CHs, Cl, HOCH2CH2OCH2CH2, CHa), (M-6355, F, CHs, Cl, (Me)2N, Η), (M-6356, F, CHs, Cl, (Me)2N, Cl), (M-6357, F, CHa, Cl, (Me)2N, F), (M-6358, 195 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） — — rill·— — — — ·1111111 — — — — — — — (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 _______B7 五、發明說明（t?4 ) F, CH3, Cl, (Me)2N, CFs), (M-6359, F, CHs, Cl, (Me)2N, Br), (M-6360, F, CH3, Cl, (Me)2N, CH3), (Μ·6361, F, CH3, Cl,哌啶-4 -棊甲基，Η), (M-6362, F，CH3,
Cl,哌啶-4 -基甲基，Cl), (M_6363, F, CH3, Cl,哌啶 _ 4 -基甲基，F), (M-6364, F, CH3, Cl,哌啶-4 -基甲基，CF3), (M-6365, F，CH3, Cl, 喊陡-4-基甲基.，Br)，（M-6366，F，CH3，Cl，派 B定-4 -基甲.基，CIU)， (M-6367, F, CH3, Cl,環己基甲基丨，Η), (M-6368, F, CH3, Cl, 環己基甲基，Cl), (M-6369, F, CH3, Cl,環己基甲基，F), (M-6370, F， CH3, Cl,，環己基甲基,，CF3), (M-6371, F, CH3, Cl,環己基甲基，Br)， (Μ·6372, F, CH3, Cl,環己基甲基，（^3),(]^-6373，（：1,11,11,11,11)，（]^· 6374, Cl, Η, Η, H, Cl), (M-6375, MeO, F, Η, H, F), (M-6376, MeO, F, Η, H, c-Pr), (M-6377, Cl, Η, Η, H, Br), (M-6378, Cl, Η, Η, H, CH3), (M-6379, MeO, H，H，F, c-Pr), (M-6380, Cl, Η, H, F, Cl), (M-6381, MeO, Η, H, F, F>, (M-6382, Cl，Η, H, F, CF3), (Μ·6383, Cl, Η, H, F, Br), (M-6384, Cl, Η, H, F, CH3), (M-6385, Cl，H， H, Cl, Η), (M-6386, MeO, F, Η, H, Et), (M-6387, MeO, Η, H, Cl, F), (M-6388, Cl， Η, H, Cl, CF3), (M-6389, Cl, Η, H, Cl, Br), (M-6390, Cl, Η, H, Cl，CH3), (M-6391，
Cl, Η, H, CHa, Η), (M-6392, Cl, Η, H, CHa, Cl), (M-6393, Cl, Η, H, CHa, F), (M-6394, Cl, Η, H, CH3, CF3), (M-6395, Cl, Η, H, CH3, Br), (M-6396, Cl, Η, H, CH3, CH3), (M-6397, Cl, Η, H, Et, Η), (M-6398, Cl, Η, H, Et, Cl>, (M-6399, Cl, H, H, Et, F), (M-6400, Cl, Η, H, Et, CF3), (M-6401, Cl, Η, H, Et，Br)，（M-6402, Cl, Η, H, Et, CHs), (M-6403, Cl, Η, H, n-Pr, Η), (M-6404, Cl, Η, H, n-Pr, Cl), (M- 6405, Cl, Η, H, n-Pr, F), (M-6406, Cl, Η, H, n-Pr, CFa), (M-6407, Cl, Η, H, n-
Pr, Br), (M-6408, Cl, Η, H, n-Pr, CH3), (M-6409, Cl, Η, H, c-Pr, Η), (M-6410, Cl， H,H,c-Pr,Cl),(M-6411,Cl,H，H,c-Pr,F),(M-6412，Cl,H,II，c-Pr,CF3)，（M· 6413, Cl, Η, H, c-Pr, Br), (M-6414, Cl, Η, H, c-Pr, CHa), (M-6415, Cl, Η, H, i-
Pr, Η), (M-6416, Cl, Η, H, i-Pr, Cl), (M-6417, Cl, Η, H, i-Pr, F), (M-6418, Cl, H, H, i-Pr, CF3), (M-6419, Cl, Η, H, i-Pr, Br), (M-6420, Cl, Η, H, i-Pr, CH3), (M· 196 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） — 丨：----L-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 __________B7_____ 五、發明說明（19X) 6421, MeO, Η, Η, n-Bu, Η), (Μ-6422, Cl, Η, Η, n-Bu, Cl), (Μ-6423, Cl, Η, Η, n-Bu, F), (Μ-6424, C1, Η, Η, n-Bu, CF3), (Μ·6425, C1, Η, Η, η·Βιι, Br), (Μ-6426， C1, Η, Η, n-Bu, CHa), (Μ-6427, Cl, Η, Η, i-Bu, Η), (Μ-6428, C1, Η, Η, i-Bu, Cl), (Μ·6429, Cl, Η, Η, i-Bu, F), (Μ-6430, Cl, Η, Η, i-Bu，CF3), (Μ-6431, Cl, Η· Η· i-Bu, Br), (Μ-6432, Cl, Η, Η, i-Bu, CHs), (Μ-6433, Cl, Η, Η, sec-Bu, Η), (Μ-6434, C1, Η, Η, sec-Bu, Cl), (Μ-6435, C1, Η, Η, sec-Bu, F), (Μ-6436, C1, Η, Η, sec-Bu， CF3), (Μ-6437, Cl, Η, Η, sec-Bu, Br), (Μ·6438, Cl, Η, Η, sec-Bu，CH3)，（Μ-6439, Cl, Η, Η, n-Pen, Η), (Μ-6440, C1, Η, Η, n-Pen, Cl), (Μ-6441, MeO, Η, Η, n-Pen, F), (Μ-6442, Cl, Η, Η, n-Pen, CF3), (Μ·6443, Cl, Η, Η, n-Pen, Br), (Μ-6444, C1， Η, Η, n-Pen, CH3), (Μ-6445, Cl, Η, Η, c-Pen, Η), (Μ-6446, Cl, Η, Η, c-Pen，Cl), (Μ·6447, Cl, Η, Η, c-Pen, F), (Μ-6448, Cl, Η, Η, c-Pen, CF3), (Μ-6449, Cl, Η, Η， c-Pen, Br), (Μ-6450, Cl, Η, Η, c-Pen, CH3), (Μ-6451, C1, Η, Η, η-Hex, Η), (Μ-6452, C1, Η, Η, n-Hex, Cl), (Μ-6453, C1, Η, Η, n-Hex, F), (Μ-6454, C1, Η, Η， n-Hex, CF3), (Μ-6455, Cl, Η, Η, n-Hex, Br), (Μ-6456, Cl, Η, Η, n-Hex, CH3), (Μ-6457, C1, Η, Η, c-Hex, Η), (Μ-6458, C1, Η, Η, c-Hex, Cl), (Μ-6459, Cl, Η, Η, c-Hex, F), (Μ-6460, C1, Η, Η, c-Hex, CFs), (Μ-6461, Cl, Η, Η, c-Hex, Br), (Μ-6462, Cl, Η, Η, c-Hex, CH3), (Μ-6463, Cl, Η, Η, ΟΗ，Η), (Μ-6464, Cl, Η, Η, ΟΗ， Cl), (Μ-6465, C1, Η, Η, OH, F), (Μ-6466, C1, Η, Η，〇Η, CF3), (Μ-6467, C1，Η, Η, OH, Br), (Μ-6468, C1, Η, Η, OH, CH3), (Μ·6469, C1, Η, Η, EtO, Η), (Μ-6470, C1， Η, Η, EtO, Cl)，（Μ-6471, C1, Η, Η, EtO, F), (Μ-6472, C1，Η, Η，EtO, CF3)，（Μ-6473, Cl, Η, Η, EtO, Br), (Μ-6474, Cl, Η, Η, EtO, CII3), (Μ-6475, C1, Η, Η, η-pr〇, Η), (Μ-6476, C1, Η, Η, n-PrO, Cl), (Μ-6477, C1，Η, Η, n-PrO, F), (Μ-6478, C1, Η, Η, n-PrO, CF3), (Μ-6479, C1, Η, Η, n-PrO, Br), (Μ-6480, Cl, Η，Η，n-PrO, CH3), (Μ-6481, C1, Η, Η, PhO, Η), (Μ-6482, C1, Η, Η, PhO, Cl), (Μ-6483, Cl, Η, Η, PhO, F), (Μ-6484, C1, Η, Η, PhO, CF3), (Μ-6485, Cl, Η, Η, PhO, Br), (Μ-6486,
Cl, Η, Η, PhO, CH3), (Μ-6487, Cl, Η, Η, ΒηΟ, Η), (Μ-6488, Cl, Η, Η, ΒηΟ, C1)， 197 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公釐） ---：----1--------- (請先閱讀背面之注意事項再填寫本頁) 訂--- 1284639 A7 B7 五、發明說明（Wfc) (M-6489, Cl, Η, Η, ΒηΟ, F), (Μ-6490, C1, Η, Η, ΒηΟ, CFs), (Μ-6491, C1, Η, Η, BnO, Br), (Μ-6492, C1, Η, Η, ΒηΟ, CH3), (Μ-6493, C1, Η, Η, PhCH2CH2〇, Η), (Μ-6494, C1, Η, Η, PhCH2CH2〇, Cl), (Μ-6495, C1, Η, Η, PhCH2CH2〇, F), (Μ-6496,Cl,H,H,PhCH2CH2〇,CF3),(M-6497，Cl,H，H,PhCH2CH2〇，Br)，（M· 6498, Cl, Η, Η, PhCH2CH2〇, CHa), (Μ-6499, MeO, Η, II, CFaO, CFa), (Μ-65ϋϋ, Cl, Η, Η, CF3〇, Cl), (Μ-6501, Cl, Η, Η, CF3〇, F), (Μ-6502, Cl, Η, Η, CF3〇, CF3)， (Μ-6503, Cl, Η, Η, CF3〇, Br), (Μ-6504, Cl, Η, Η, CF3〇, CH3), (Μ-6505, MeO, Η， Η, Ph, Η), (Μ-6506, Cl, Η, Η, Ph, Cl), (Μ-6507, Cl, Η, Η, Ph, F), (Μ-6508, Cl，Η， Η, Ph，CF3), (Μ-6509, Cl, Η, Η, Ph, Br)，（Μ-6510, C1，Η, Η, Ph，CHa)，（M-G511， Cl, Η，Η, 4-F-Ph, Η), (Μ-6512, Cl, Η, Η, 4-F-Ph, Cl), (Μ-6513, Cl, Η, Η, 4-F-Ph， F), (Μ-6514, Cl, Η, Η, 4-F-Ph, CF3), (Μ-6515, Cl, Η, Η, 4-F-Ph, Br), (Μ-6516, C1， H,H,4-F-Ph,CH3),(M-6517,Cl,H,H,4-CF3-Ph,H),(M-6518,Cl，H，H,4-CF3-Ph, Cl), (Μ-6519, Cl, Η, Η, 4-CF3-Ph, F), (Μ-6520, C1，Η, Η, 4-CF3-Ph，CF3), (M-6521, Cl, Η, H, 4-CF3-Ph, Br), (M-6522, Cl, Η, H, 4-CF3-Ph, CH3), (M-6523, Cl, Η, H, 4-(Me)2N.Ph, Η), (M-6524, Cl, Η, H, 4-(Me)2N-Ph, Cl), (M-6525, Cl, H, H, 4-(Me)2N-Ph, F), (M-6526, Cl, Η, H, 4-(Me)2N-Ph，CF3), (M-6527, Cl, Η, H， 4-(Me)2N-Ph, Br), (M-6528, Cl, Η, H, 4-(Me)2N-Ph, CHa), (M-6529, Cl, Η, H, 4-OH-Ph, Η), (M-6530, Cl, Η, H, 4-OH-Ph, Cl), (M-6531, Cl, Η, H, 4-OH-Ph，F)， (M-6532, Cl, Η, H, 4-OH-Ph, CF3), (M-6533, Cl, Η, H, 4-OH-Ph, Br), (Μ·6534， Cl, Η, H, 4-OH-Ph, CH3), (M-6535, Cl, Η, H, 3,4-di-F-Ph, Η), (M-6536, Cl, H，H， 3,4-di.F-Ph, Cl), (M-6537, Cl, Η, H, 3,4-di-F-Ph, F), (M-6538, Cl, Η, H, 3,4-cli-F-Ph, CF3), (M-6539, Cl, Η, H, 3,4-di-F-Ph, Br)，（M-G540, Cl, Η, H, 3,4-di-F-Ph， CH3), (M-6541, Cl, Η, H, 4-COOH-Ph, Η), (M-6542, Cl, Η, H, 4-COOH-Ph，Cl)， (M-6543, Cl, Η, H, 4-COOH-Ph, F), (M-6544, Cl, H，H，4-COOH-Ph，CF3), (M· 6545, Cl, Η, H, 4-COOH-Ph, Br), (M-6546, Cl, H，H, 4-COOH-Ph, CH3), (Μ·6547, Cl, Η, Η, Bn, Η), (M-6548, Cl, Η, H, Bn, Cl), (M-6549, Cl，Η, H, Bn，F), (M-6550, 198 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ——：----L----- (請先閱讀背面之注意事項再填寫本頁) 訂--- 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 __B7_____ 五述Μ ί F3), (Ιΐ·6551, Cl, Η, Η, Bn, Br), (Μ-6552, Cl, Η, Η, Bn, CH3)， (Μ·6553, Cl, Η, Η, 4-F-Bn, Η), (Μ-6554, Cl, Η, Η, 4-F-Bn, Cl), (Μ-6555, Cl，Η, Η, 4-F-Bn, F), (Μ-6556, Cl, Η, Η, 4-F-Bn, CF3), (Μ-6557, Cl, Η，Η, 4-F-Bn，Br)， (Μ·6558, Cl, Η, Η, 4-F-Bn, CH3), (Μ-6559, Cl, Η, Η，2-Py, Η), (Μ·6560, Cl, Η，Η， 2- Py, Ci), (Μ-6561, Cl, Η, Ιί, 2-Py, 1〇, (Μ.0502, Cl, II, II, 2-l'y, CK〇, (Μ-ΠηΟΜ, C1, Η, Η, 2-Py, Br), (Μ-6564, C1, Η, Η, 2-Py, CH3), (Μ-6565, C1, Η, Η, 3-Py, Η)， (Μ-6566, C1, Η, Η, 3-Py, Cl), (Μ-6567, C1, Η, Η, 3-Py, F), (Μ-6568, Cl，Η，Η， 3- Py, CF3), (Μ-6569, C1, Η, Η，3-Py, Br), (Μ-6570, C1，Η, Η, 3-Py，CH3), (Μ-6571， Cl, Η，Η, 4-Py, Η), (Μ-6572, Cl, Η, Η, 4-Py, Cl), (Μ-6573, C1，Η, Η, 4-Py，F), (Μ-6574, Cl, Η, Η, 4-Py, CF3), (Μ-6575, Cl, Η, Η, 4-Py, Br), (Μ-6576, Cl, Η，Η, 4- Py, CH3), (Μ-6577, Cl, Η，Η, 2-Th, Η), (Μ-6578, C1, Η, Η, 2-Th, Cl), (Μ-6579, C1, Η, Η, 2·Τ1ι, F), (Μ-6580, C1, Η, Η, 2-Th, CF3), (Μ-6581, C1, Η, Η, 2-Th，Br)， (Μ-6582, Cl, Η, Η, 2-Th, CH3), (Μ·6583, Cl, Η, Η, 3-Th, Η), (Μ-6584, Cl, II，II， 3-Th, Cl), (Μ-6585, Cl, Η, Η, 3-Th, F), (Μ-6586, C1，Η, Η, 3-Th，CF3), (Μ·6587, Cl, Η, Η, 3-Th, Br), (Μ·6588, Cl, Η, Η, 3-Th, CH3), (Μ-6589, Cl, Η, Η, 吡唑-2-基，Η), (Μ·6590, C1, Η, Η,妣唑-2·基，Cl), (Μ-6591, C1, Η, Η, 吡唑-2-基，F), (Μ-6592, C1, Η, Η,妣唑-2·基，CF3), (Μ-6593, C1, Η, Η, 吡唑·2·基，Br), (Μ-6594, C1, Η, Η,吡唑-3-棊，CH3)，(M-6595, C1, Η，Η， 吡唑-3-基，Η), (Μ-6596, Cl, Η, Η,吡唑-3-基'1), (Μ-6597, Cl, Η，Η, 吡唑-3-基，F), (Μ-6598, C1, Η, Η,毗唑-3-基，CF3), (Μ-6599, Cl, Η，Η， 吡唑-3-基，Br), (Μ:6600, C1, Η, Η,毗唑·3-基，CH3), (Μ·6601，C1，Η, Η， 嘧啶-2‘基，Η), (Μ·6602, Cl, Η，Η,嘧啶-2-基，Cl), (Μ-6603, Cl，Η，Η， 嘧啶-2-基，F), (Μ·6604, Cl, Η, Η,嘧啶·2·基，CF3)，（Μ-6605, Cl，Η, Η， 嘧啶-2-基 > Br), (Μ·66〇6, Cl，Η，Η,嘧啶·2·基，CH3)，（Μ·66〇7, C1, Η, Η， 嘧啶-4·基，Η), (Μ-6608, C1, Η, Η,嘧啶·4-基，Cl), (Μ-6609, C1, Η, Η、 唪啶-4-基，ρ), (Μ-6610, Cl, Η，Η,嘧啶-4-基，CF3), (Μ-6611, C1, Η, Η, 199 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） —：----：-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五 ^^^^ί?ϊ，（ΒΓ),^ν[·6612, Cl, Η, Η,嘧啶-4-基，CH3)，（M-6613, C1，H，H, 嘧啶·5-基，Η), (M-6614, Cl, Η, H,嘧啶-5-基，Cl), (M-6615, Cl，H，H， 嘧啶-5-基，F), (M-6616, Cl, Η, H,喃啶-5-基，CF3), (Μ·6617, Cl, Η, H, 嘧啶-5-基，Br), (M-6618, Cl, Η, H,嘧啶-5-基，CH3), (M-6619, Cl, Η, H， HOOCCH2CH2CH2, II), (M.G020, Cl, JI, II, llOOCCIhClIaiMh, (：I), (M, Η, H, HOOCCH2CH2CH2, F), (M-6622, Cl, Η, H, HOOCCH2CH2CH2, CFs), (M-6623, Cl, Η, H, HOOCCH2CH2CH2, Br), (M-6624, Cl, Η, H, HOOCCH2CH2CH2, CHs), (M-6625, Cl, Η, H, HOOCCH2CH2CH2CH2, Η), (M-6626, Cl, Η, H, HOOCCH2CH2CH2CH2, Cl), (M-6627, Cl, Η, H, HOOCCH2CH2CH2CH2, F), (M-6628, Cl, Η, H, HOOCCH2CH2CH2CH2, CFa), (M-6629, Cl, Η, H, HOOCCH2CH2CH2CH2, Br), (M-6630, Cl, Η, H, HOOCCH2CH2CH2CH2, CH3), (M-6631, Cl, Η, H, (Me)2NCOCH2CH2CH2CH2, Η), (M-6632, Cl，Η, H, (Me)2NCOCH2CH2CH2CH2, Cl), (M-6633, Cl, Η, H, (Me)2NCOCH2CH2CH2CH2, F), (M-6634, Cl, Η, H, (Me)2NCOCH2CH2CH2CH2, CF3), (M-6635, Cl，Η, H， (Me)2NCOCH2CH2CH2CH2, Br), (M-6636, Cl, Η, H, (Me)2NCOCH2CH2CH2CH2, CH3), (M-6637, Cl, Η, H, (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-6638, Cl，Η, H， (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-6639, Cl, Η, H, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-6640, Cl, Η, H, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-6641, Cl, Η, H, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-6642, Cl, Η, H, (Me)2NCOCH2CH2CHiCH2CH2, CH3), (M-6643, Cl, Η, H，MeOCH2, Η), (M-6644, Cl, Η, H, MeOCH2, Cl), (M-6645, Cl, Η, H, MeOCH2, F), (M-6646, Cl，Η, H， MeOCH2, CF3), (M-6647, Cl, Η, H, MeOCH2, Br), (M-6648, Cl，H，H, MeOCH2, CH3)，（M-6649, Cl, Η, H，EtOCH2, Η), (M-6650, Cl, H，H, EtOCtb，Cl)，（M-6651， Cl, Η, H, EtOCH2, F), (M-6652, Cl, Η, H, EtOCH2, CF3), (M-6653, Cl, H，H， EtOCH2, Br), (M-6654, Cl, Η, H, EtOCH2, CH3), (M-6655, Cl，Η, H，EtOCH2CH2, 200 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ____ (請先閱讀背面之注意事項再填寫本頁)
訂---------♦丨 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（丨99 ) Η), (M-6656, Cl, Η, H, EtOCH2CH2, Cl), (M-6657, Cl, Η, H, EtOCH2CH2, F), (M-6658, Cl, Η, H, EtOCH2CH2, CF3), (M-6659, Cl, Η, H, EtOCH2CH2, Br)， (M-6660, Cl, Η, H, EtOCH2CH2, CH3), (M-6661, Cl, H，H, MeOCH2CH2〇CH2CH2, Η), (M-6662, Cl，Η, H, MeOCH2CH2〇CH2CH2, Cl), (M-6663, Cl, Η, H, MeOCH2CH2〇CH2CH2, F), (M-66G4, Cl, II, II, MeOCH2CH2〇CH2CH2, CF3), (M-6665, Cl, Η, H, MeOCH2CH2〇CH2CH2, Br), (M-6666, Cl, Η, H, MeOCH2CH2〇CH2CH2, CH3), (M-6667, Cl, Η, H, MeOCH2CH2, Η), (M-6668, Cl, Η, H, MeOCH2CH2, Cl), (M-6G69, Cl, Η, H, MeOCH2CH2, F), (M-6670, Cl, Η, H，MeOCH2CH2, CF3), (M-6671, Cl, Η, H， MeOCH2CH2, Br), (M-6672, Cl, Η, H, MeOCH2CH2, CH3)，（M-6673, Cl, Η, H， HOCH2, Η), (M-6674, Cl, Η, H, HOCH2, Cl), (M-6675, Cl, Η, H, HOCH2, F), (M-6676, Cl, Η, H, HOCH2, CF3), (M-6677, Cl, Η, H, HOCH2, Br), (M-6678, Cl, Η, H, HOCH2, CHa), (M-6679, Cl, Η, H, HOCH2CH2, Η), (M-6680, Cl, Η, H, HOCH2CH2, Cl), (M-6681, Cl, Η, H, HOCH2CH2, F), (M-6682, Cl, Η, H, HOCH2CH2, CF3), (M-6683, Cl, Η, H, HOCH2CH2, Br), (Μ·6684, Cl, Η, H, HOCH2CH2, CHa), (M-6685, Cl, Η, H, HOCH2CH2CH2, Η), (M-6686, Cl, Η, H, HOCH2CH2CH2, Cl), (M-6687, Cl, Η, H, HOCH2CH2CH2, F), (M-6688, Cl, Η, H, HOCH2CH2CH2, CFs), (M-6689, Cl, Η, H, HOCH2CH2CH2, Br), (M-6690, Cl, H, H, HOCH2CH2CH2, CHa), (M-6691, Cl, Η, H, HOCH2CH2CH2CH2, Η), (M-6692, Cl, Η, H, HOCH2CH2CH2CH2, Cl), (M-6693, Cl, Η, H, HOCH2CH2CH2CH2, F), (M-6694, Cl, Η, H, HOCH2CH2CH2CH2, CFa), (M-6695, Cl, Η, H, HOCH2CH2CH2CH2, Br), (M-6696, Cl, Η, H, HOCH2GH2CH2CH2, CHa), (M-6697, Cl, Η, H, HOCH2CH2CH2CH2CH2, Η), (M-6698, Cl, Η, H, HOCH2CH2CH2CH2CH2, Cl), (M-6699, Cl, Η, H, HOCH2CH2CH2CH2CH2, F)， (M-6700, Cl, Η, H, HOCH2CH2CH2CH2CH2, CFs), (M-6701, Cl, Η, H, HOCH2CH2CH2CH2CH2, Br), (M-6702, Cl, Η, H, HOCH2CH2CH2CH2CH2, CHs), 201 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） —«I Bp ϋ ϋ ϋ 1 ϋ ϋ 1 ϋ 一δτ ϋ ϋ ^1 ϋ ϋ ϋ H I (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 -----—_Β7_ ；_ 五、發明說明（ >押） (請先閱讀背面之注意事項再填寫本頁) (M-6703, Cl, Η, H, HOCH2CH2OCH2CH2, Η), (Μ-6704, C1, Η, Η, HOCH2CH2〇CH2CH2, Cl), (Μ-6706, Cl, Η, Η, HOCH2CH2OCH2CH2, F), (Μ-6706, C1, Η, Η, HOCH2CH2OCH2CH2, CFs), (Μ-6707, C1, Η, Η, HOCH2CH2OCH2CH2, Br), (Μ-6708, C1, Η, Η, HOCH2CH2OCH2CH2, CH3), (Μ-6709, C1, Η, Η, (Me)2N, Η), (Μ-6710, C1, Η, Η, (Μο)2Ν, Cl), (M-G711, C1, 11, Η, (Me)2N, F), (Μ-6712, C1, Η, Η, (Me)2N, CF3), (Μ-6713, Cl, Η，Η, (Me)2N, Br)， (Μ-6714, Cl, Η, Η, (Me)2N, CH3), (Μ-6715, Cl, Η, Η,哌啶-4 基甲基 L Η)， (Μ·6716, Cl, Η, Η,哌啶-4 -基甲基，Cl), (M-Wl7, Cl, Η, Η,哌啶-4 基甲基，F), (Μ-6718, Cl, Η, Η,哌啶-4 -基甲基，CF3), (Μ·6719, Cl, Η， H,哌啶 4 -基甲基，Br), (M-6720, Cl, Η, H,哌啶-4 -基甲基，CH3), (M-6721, Cl, Η, Η,環己基甲基，H), (M-6722, Cl, Η, Η,環己基甲基 ^ Cl), (M-6723, Cl, Η, H,環己基甲基，F), (M-6724, Cl, Η, Η, 經濟部智慧財產局員工消費合作社印製 環己基甲基，CFa), (Μ·6725, Cl, H, HL,環己基甲基,Br), (M·6726, Cl, Η, Η,環己基甲基，CH3), (Μ-6727, MeO, Η, F, Η, Η), (Μ-6728, Cl, Η, F，Η， Cl), (Μ-6729, MeO, Η, F; Η, F), (Μ·6730, MeO, Η, F, Η, CF3), (Μ-6731, MeO, Η, F，Η, Br), (Μ-6732, MeO, Η, F, Η, CH3), (Μ-6733, MeO, Η, F, F, Η), (Μ-6734, C1， Η，F, F, Cl), (Μ-6735, C1, Η, F, F, F)，（Μ-6736, C1, Η, F, F, CF3), (Μ-6737, Cl, Η， F, F, Br), (Μ-6738, C1, Η, F, F, CH3), (Μ-6739, C1, Η, F, C1, Η), (Μ-6740, C1, Η, F, Cl, Cl), (Μ-6741, C1, Η, F, Cl, F), (Μ-6742, C1, Η, F, Cl, CF3), (Μ-6743, C1, Η, F, Cl, Br), (Μ·6744, C1, Η, F, Cl, CH3), (Μ-6745, MeO, Η, F, CH3, Η), (Μ-6746, C1, Η, F, CH3, Cl), (Μ-6747, Cl, Η, F, CHa, F), (Μ-6748, Cl, Η, F, CHa, CFs), (M-6749, Cl, H, F, CHa, Br), (M-6750, Cl, H, F, CHa, CH3), (M-6751, MeO, H, F, Et, Η), (M-6752, Cl, H, F, Et, Cl), (M-6753, Cl, H, F, Et, F), (M-6754, Cl, H，F， Et, CFa), (M-6755, Cl, H, F, Et，Br), (M-6756, Cl, H, F, Et, CH3)，（M-6757, MeO, H, F, n-Pr, Η), (M-6758, Cl, H, F, n-Pr, Cl), (M-6759, Cl，H, F, n-Pr, F)，（M-6760, Cl, H, F, n-Pr, CFs), (M-6761, MeO, H, F, n-Pr, Br), (M-6762, Cl, H, F, n-Pr, 202 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公髮） 1284639 A7 ___B7 _ 五、發明說明（W ) (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 CH3), (M-6763, Cl, H，F, c-Pr, Η), (M-6764, Cl, H, F, oPr, Cl), (M-6765, Cl, H， F, c-Pr, F), (M-6766, Cl, H, F, c-Pr, CF3), (M-6767, Cl, H, F, c-Pr, Br), (M-6768, Cl, H, F, c-Pr, CH3), (M-6769, Cl, H, F, i-Pr, Η), (M-6770, Cl, H, F, i-Pr, Cl), (M-6771,Cl，H,F,i-Pr,F),(M-6772,Cl,H,F,i-Pr,CF3),(M-6773,Cl,H,F,i· Pr, Br), (M-6774, Cl, H, F, i-Pr, CHa), (M-6775, MeO, M, F, n-Bu, 11), (M-G77G, Cl, H, F, n-Bu, Cl), (M-6777, Cl, H, F, n-Bu, F), (M-6778, Cl, H, F, n-Bu，CF3)， (M-6779, Cl, H, F, n-Bu, Br), (M-6780, Cl, H, F, n-Bu, CH3)，（M-6781，Cl, H，F， i-Bu, Η), (M-6782, Cl, H, F, i-Bu, Cl), (M-6783, Cl, H, F, i-Bu, F), (M-6784, Cl， H, F, i-Bu, CF3), (M-6785, Cl, H, F, i-Bu, Br), (M-6786, Cl, H，F, i-Bu, CHs)， (M-6787, Cl, H, F, sec-Bu, Η), (M-6788, Cl, H, F, sec-Bu, Cl), (M-6789, Cl, H, F, sec-Bu, F), (M-6790, Cl, H, F, sec-Bu, CF3), (M-6791, Cl, H, F, sec-Bu, Br), (M-6792, Cl, H, F, sec-Bu, CHs), (M-6793, MeO, H, F, n-Pen, Η), (M-6794, Cl, H, F, n-Pen, Cl), (M-6795, MeO, H, F, n-Pen, F), (M-6796, Cl, H, F, n-Pen, CFs)， (M-6797, Cl, H, F, n-Pen, Br)，（M-6798, Cl, H, F, n-Pen, CH3), (M-6799, Cl，H，F， c-Pen, Η), (M-6800, Cl, H, F, c-Pen, Cl), (M-6801, Cl, H, F, c-Pen, F)，（Μ·6802, Cl, H, F, c-Pen, CF3), (M-6803, Cl, H, F, c-Pen, Br), (Μ·6804, Cl, H, F, c-Pen, CH3), (M-6805, MeO, H, F, n-Hex, Η), (M-6806, Cl, H, F, n-Hex, Cl), (M-6807, Cl, H, F, n-Hex, F), (M-6808, Cl, H, F, n-Hex, CFa), (M-6809, Cl, H, F, n-Hex, Br), (M-6810, Cl, H, F, n-Hex, CH3), (M-6811, MeO, H, F, c-Hex, Η), (M-6812, Cl, H, F, c-Hex, Cl), (M-6813, Cl, H, F, c-Hex, F), (Μ·6814, Cl, H, F, c-Hex, CF3)· (M-6815, Cl, H, F, c-Hex, Br), (M-6816, Cl, H, F, c-Hex, CHa), (M-6817, Cl, H, F, OH, Η), (M-6818, Cl, H, F, OH, Cl), (M-6819, Cl, H, F, OH, F), (M-6820, Cl, H, F, OH, CF3), (M-6821, Cl, H, F, OH, Br), (M-6822, Cl, H, F, OH, CH3), (Μ·6823, MeO, H, F, EtO, Η), (M-6824, Cl, H, F, EtO, Cl), (M-6825, Cl, H, F, EtO, F), (M-6826, Cl, H, F, EtO, CF3)，（M-6827, Cl, H, F, EtO, Br), (M-6828, Cl, H，F， EtO, CH3), (M-6829, Cl, H, F, n-PrO, H)，（M-6830, Cl, H, F，n-PrO, Cl), (M-6831， 203 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 _B7____ 五、發明說明（x>) (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製
Cl, H, F, n-PrO, F), (M-6832, Cl, H, F, n-PrO, CFa), (M-6833, Cl, H, F, n-PrO, Br), (M-6834, Cl, H, F, n-PrO, CH3), (M-6835, Cl, H, F, PhO, Η), (M-6836, Cl, H, F, PhO, Cl), (M-6837, Cl, H, F, PhO, F), (M-6838, Cl, H, F, PhO, CF3)，（M-6839, Cl, H, F, PhO, Br), (M-6840, Cl, H, F, PhO, CH3)，（M-6841, Cl, H, F，BnO, H)， (M-6842, Cl, H, F, BnO, Cl), (M-6843, Cl, H, F, BnO, F), (M-G844, Cl, II, F, BnU, CF3), (Μ·6845, Cl, H, F, BnO, Br), (M-6846, Cl, H, F, BnO, CH3), (M-6847, Cl, H, F, PhCH2CH2〇, Η), (M-6848, Cl, H, F, PhCH2CH2〇, Cl), (M-6849, Cl，H, F, PhCH2CH2〇, F), (M-6850, Cl, H, F, PhCH2CH2〇, CF3), (M-6851, Cl, H，F, PhCH2CH2〇, Br), (M-6852, Cl, H, F, PhCH2CH2〇, CH3), (M-6853, Cl，H，F， CF3〇, Η), (M-6854, Cl, H, F, CF3〇, Cl), (M-6855, Cl，H, F, CF3〇, F), (M-6856, Cl, H, F, CF3〇, CF3), (M-6857, Cl, H, F, CF3〇, Br), (M-6858, Cl, H, F, CF3〇， CH3), (M-6859, MeO, H, F, Ph, Η), (M-6860, Cl, H, F, Ph, Cl)，（M-6861, MeO, H, F, Ph, F), (M-6862, Cl, H, F, Ph, CF3), (M-6863, Cl, H, F, Ph, Br), (M-6864, Cl, H, F, Ph, CH3), (M-6865, MeO, H, F, 4-F-Ph, Η), (M-6866, Cl, H, F, 4-F-Ph, Cl)， (M-6867, Cl, H, F, 4-F-Ph, F), (M-6868, Cl, H, F, 4-F-Ph, CF3), (M-6869, Cl, H， F, 4-F-Ph, Br), (M-6870, Cl, H, F, 4-F-Ph, CH3), (M-6871, Cl, H, F, 4-CF3-Ph，H)， (Μ·6872, Cl, H, F，4-CF3-Ph, Cl), (M-6873, Cl, H，F, 4-CF3-Ph, F)，（M-6874, Cl， H,F,4-CF3-Ph,CF3),(M-6875,Cl,H,F,4-CF3_Ph,Br)，（M-6876,Cl,H，F，4· CFa-Ph, CHa), (M-6877, Cl, H, F, 4-(Me)2N.Ph, Η), (M-6878, Cl, H, F, 4-(Me)2N-Ph,Cl),(M-6879,Cl,H,F,4-(Me)2N-Ph,F),(M-6880，Cl，H，F，4-(Me)2N-Ph, CFa), (M-6881, Cl, H, F, 4-(Me)2N-Ph, Br), (M-6882, Cl, H, F, 4-(Me)2N-Ph, CHa), (M-6883, Cl, H, F, 4-OH-Ph, Η), (M-6884, Cl, H, F, 4-OH-Ph, Cl), (M-6885, Cl, H, F, 4-OH-Ph, F), (M-6886, Cl, H, F, 4-OH-Ph, CFs)，（Μ·6887, Cl, H, F, 4-OH-Ph, Br), (M-6888, Cl, H, F, 4-OH-Ph，CH3)，（M-6889, Cl, H, F， 3,4-di-F-Ph,H),(M-6890,Cl，H，F,3,4-di-F-Ph，Cl)，（M-6891,Cl,H,F，3,4.di· F-Ph, F), (M-6892, Cl, H, F, 3,4-di-F-Ph, CF3), (M-6893, Cl, H, F, 3,4-di-F-Ph， 204 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（>4)
Br), (M-6894, Cl, H, F, 3,4-di-F-Ph, CHa), (M-6895, Cl, H, F, 4-COOH-Ph, H), (M-6896, Cl, H, F, 4-COOH-Ph，Cl), (M-6897, Cl, H, F, 4-COOH-Ph, F), (M-6898, Cl, H, F, 4-COOH-Ph, CFa), (M-6899, Cl, H, F, 4-COOH-Ph, Br), (M-6900, Cl, H， F, 4-COOH-Ph, CH3), (M-6901, MeO, H, F, Bn，Η), (M-6902, Cl，H，F，Bn，Cl), (M-6903, Cl, H, F, Bn, F), (M-6904, Cl, H, F, Bn, CF3), (M-6905, Cl, 11, F, Bn, Br), (M-6906, Cl, H, F, Bn, CH3), (M-6907, Cl, H, F, 4-F-Bn, Η), (M-6908, Cl, H, F, 4-F-Bn, Cl), (M-6909, Cl, H, F, 4-F-Bn, F), (M-6910, Cl, H, F, 4-F-Bn, CFa), (M-6911, Cl, H, F, 4-F-Bn, Br), (M-6912, Cl, H, F, 4-F-Bn, CH3), (M-6913, Cl, H， F, 2-Py, Η), (M-6914, Cl, H, F, 2-Py, Cl), (M-6915, Cl, H，F, 2-Py, F), (M-6916, Cl, H, F, 2-Py, CF3), (M-6917, Cl, H, F, 2-Py, Br), (Μ·6918, Cl，H, F, 2-Py, CH3), (Μ·6919, MeO, H, F, 3-Py, Η), (M-6920, Cl, H, F, 3-Py, Cl), (M-6921，Cl，H, F， 3- Py, F), (M-6922, Cl, H, F, 3-Py, CF3), (M-6923, Cl, H, F, 3-Py, Br), (M-6924, Cl, H, F, 3-Py, CH3), (M-6925, Cl, H, F, 4-Py, Η), (M-6926, Cl, H, F, 4-Py，Cl), (M-6927, Cl, H, F, 4-Py，F), (M-6928, Cl, H, F, 4-Py, CF3), (M-6929, Cl, H, F， 4- Py, Br), (M-6930, Cl, H, F, 4-Py, CH3), (M-6931, Cl，H, F, 2-Th, H)，（M-6932, Cl，H, F, 2-Th, Cl), (M-6933, Cl, H, F, 2-Th, F), (M-6934, Cl, H, F, 2-Th，CF3)， (M-6935, Cl, H, F, 2-Th，Br), (M-6936, Cl, H, F, 2-Th, CH3), (M-6937, Cl, H，F, 3-Th, Η), (M-6938, Cl, H, F, 3-Th, Cl), (Μ·6939, Cl, H, F, 3-Th, F), (M-6940, Cl, H, F, 3-Th, CF3), (M-6941, Cl, H, F, 3-Th, Br), (M-6942, Cl, H, F, 3-Th, CH3), (M-6943, Cl, H, F,吡唑·2-_, Η), (M-6944, C1，H, F，吡唑-2-基，C1)，（M· 6945, Cl, H, F,吡唑 _2-基5?), (M-6946, Cl, H，F,吡唑-2-基，CF3), (M-6947, Cl, H, F,吡唑（M-6948, Cl, H, F,吡唑-2-基，CH3), (M-6949, Cl, H, F,吡唑-3-基，H), (M-6950, Cl, H, F,吡唑-3-基，C1)，（M-6951， Cl, H, F,吡唑-3-基，F), (Μ·6952, Cl, H, F,壯唑-¾ 基，CF3), (M-6953, Cl, H，F,吡唑-3-基，Br), (M-6954, Cl, H, F,吡唑-3-基，CH3)，（M-6955, C1，H， F,嘧啶-2 -基，H)，（M-6956, Cl, H, F,嘧啶-2 -基，Cl)，（M-6957, Cl，H，F， 205 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） " —：----1-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) _ 1284639 A7 B7 五、發明說明 嘛陡·2-基，F)，（^1-6958, Cl, H，F，喃陡-2·基，CFa)，（M-6959, Cl，H，F， 味陡-2-基，Br), (M-6960, Cl，H，F，嘧啶-2-基，CH3), (M-6961，Cl，H，F， 嘧症-4-基，Η), (M-6962, Cl, H, F,嘧啶-4-基，Cl), (M-6963, Cl, H，F, 嘧陡-4-基，F), (M-6964, Cl, H, F,嘧啶-4-基，CF3), (M-6965, Cl, H，F， 嘧陡-4-基，,Br), (M-6966, Cl, H, F,嘧啶-4-基，Gila), (M-G9G7, Cl, U，F， 觭啶-5-基，H), (M-6968, Cl, H, F,嘧啶-5_基，C1)，（M-6969，C1，H，F， 瞭陡-5·基,F)，（M-6970, Cl, H, F,喃啶-5-基，CF3), (M-6971, Cl, H, F， 嘧淀-5 -基· Br), (M-6972, Cl, H，F,嘧啶-5 ·基.，CH3), (M-6973, Cl, H，F， HOOCCH2CH2CH2, Η), (M-6974, Cl, H, F, HOOCCH2CH2CH2, Cl), (M-6975, Cl. H, F, HOOCCH2CH2CH2, F), (M-6976, Cl, H, F, HOOCCH2CH2CH2, CF3), (M-6977, Cl, H, F, HOOCCH2CH2CH2, Br), (M-6978, Cl, H, F, HOOCCH2CH2CH2, CH3), (M-6979, Cl, H, F, HOOCCH2CH2CH2CH2, H>, (M-6980, Cl, H, F, HOOCCH2CH2CH2CH2, Cl), (M-6981, Cl, H, F, HOOCCH2CH2CH2CH2, F), (M-6982, Cl, H, F, HOOCCH2CH2CH2CH2, CFs), (M-6983, Cl, H, F, HOOCCH2CH2CH2CH2, Br), (M-6984, Cl, H, F, HOOCCH2GH2CH2CH2, CHa), (M-6985, Cl, H, F, (Me)2NCOCH2CH2CH2CH2, H), (M_6986, Cl, H, F, (Me)2NCOCH2CH2CH2CH2, Cl)，（M-6987, Cl, H, F, (Me)2NCOCH2CH2CH2CH2, F), (M-6988, Cl, H, F, (Me)2NCOCH2CH2CH2CH2, CF3), (M-6989, Cl, H, F, (Me)2NCOCH2CH2CH2CH2, Br), (M-6990, Cl, H, F, (Me)2NCOCH2CH2CH2CH2, CH3), (M-6991, Cl, H, F, (Me)2NCOCH2CH2CH2CH2CH2, Η), (Μ·6992, Cl, H, F， (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-6993, Cl, H, F, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-6994, Cl, H, F, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-6995, Cl, H, F, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-6996, Cl, H, F, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-6997, Cl, H, F, MeOCH2, Η), (M-6998, Cl, H, F, MeOCH2, Cl), (M-6999, Cl, H, F, MeOCH2, F), (M-7000, Cl, H，F, 206 ^紙張尺度適用中國國家標準(CNS)A4規格（210 x 297公爱1 -丨— ·——l·----- (請先閱讀背面之注意事項再填寫本頁) 訂--------- 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7_______ 五、發明說明（^)
MeOCH2, CFa), (M-7001, Cl, H, F, MeOCH2, Br), (M-7002, Cl, H, F, MeOCH2, CHa), (M-7003, Cl, H, F, EtOCH2, Η), (M-7004, Cl, H, F, EtOCH2, Cl), (M-7005,
Cl, H, F, EtOCH2, F), (M-7006, Cl, H, F, EtOCH2, CF3), (M-7007, Cl, H, F， (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製
EtOCH2, Br), (M-7008, Cl, H, F, EtOCH2, CH3), (M-7009, MeO, H, F, EtOCH2CH2, Η), (M-7010, Cl, H, F, EtOCH2Cll2, Cl), (M-7011, 01, 11, F, EtOCH2CH2, F), (M-7012, Cl, H, F, EtOCH2CH2, CF3), (M-7013, Cl, H, F, EtOCH2CH2, Br), (M-7014, Cl, H，F, EtOCH2CH2, CH3), (M-7015, Cl, H，F, MeOCH2CH2〇CH2CH2, Η), (M-7016, Cl, H, F, MeOCH2CH2OCH2CH2, Cl)， (M-7017, Cl, H, F, MeOCH2CH2〇CH2CH2, F), (M-7018, Cl, H, F, MeOCH2CH2〇CH2CH2, CF3), (M-7019, Cl, H, F, MeOCH2CH2〇CH2CH2, Br), (M-7020, Cl, H, F, MeOCH2CH2〇CH2CH2, CH3), (M-7021, Cl, H, F, MeOCH2CH2, Η), (M-7022, Cl, H, F, MeOCH2CH2, Cl), (M-7023, Cl，H, F, MeOCH2CH2, F), (M-7024, Cl, H, F, MeOCH2CH2, CF3), (Μ·7025, Cl, H, F, MeOCH2CH2, Br), (Μ·7026, Cl, H, F, MeOCH2CH2, CH3), (M-7027, Cl, H, F, HOCH2, Η), (M-7028, Cl, H, F, HOCH2, Cl), (M-7029, Cl, H, F, HOCH2, F), (M-7030, Cl, H, F, HOCH2, CFa), (M-7031, Cl, H, F, HOCH2, Br), (M-7032, Cl，H, F, HOCH2, CH3), (M-7033, Cl, H, F, HOCH2CH2, Η), (M-7034, Cl, H, F, HOCH2CH2, Cl), (M-7035, Cl, H, F, HOCH2CH2, F), (M-7036, Cl, H, F， HOCH2CH2, CFa), (M-7037, Cl, H, F, HOCH2CH2, Br), (M-7038, Cl, H, F, HOCH2CH2, CH3), (M-7039, Cl, H, F, HOCH2CH2CH2, H)，（M-7040, Cl, H, F, HOCH2CH2CH2, Cl), (M-7041, Cl, H, F, HOCH2CH2CH2, F), (M-7042, Cl, H, F, HOCH2CH2CH2, CFa), (M-7043, Cl, H, F, HOCH2CH2CH2, Br), (M-7044, Cl, H, F, HOCH2CH2CH2, CHs), (M-7045, Cl, H, F, HOCH2CH2CH2CH2, Η), (M-7046, Cl, H, F, HOCH2CH2CH2CH2, Cl), (M-7047, Cl, H, F, HOCH2CH2CH2CH2, F), (M-7048, Cl, H, F, HOCH2CH2CH2CH2, CFa), (M-7049, Cl, H, F, HOCH2CH2CH2CH2, Br), (M-7050, Cl, H, F, HOCH2CH2CH2CH2, CH3), (M- 207 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 ___B7_____ 五、發明說明（4) 7051, Cl, H, F, HOCH2CH2CH2CH2CH2, Η), (M-7052, Cl, H, F, HOCH2CH2CH2CH2CH2, Cl), (M-7053, Cl, H, F, HOCH2CH2CH2CH2CH2, F), (M-7054, Cl, H, F, HOCH2CH2CH2CH2CH2, CFs), (M-7055, Cl, H, F, HOCH2CH2CH2CH2CH2, Br), (M-7056, Cl, H, F, HOCH2CH2CH2CH2CH2, CH3), (M-7057, Cl, H, F, HOCH2CH2OCH2CH2, Η), (M-7058, Cl, H, F, HOCH2CH2OCH2CH2, Cl), (M-7059, Cl, H, F, HOCH2CH2OCH2CH2, F), (M-7060, Cl, H, F, HOCH2CH2OCH2CH2, CFa), (M-7061, Cl, H, F, HOCH2CH2OCH2CH2, Br), (M-7062, Cl, H, F, HOCH2CH2OCH2CH2, CHa), (M-7063, Cl, H, F, (Me)2N, Η), (M-7064, Cl, H, F, (Me)2N, Cl), (M-7065, CL H, F， (Me)2N, F), (M-7066, Cl, H, F, (Me)2N, CF3), (M-7067, Cl, H, F，(Me)2N，Br), (M-7068, Cl, H, F, (Me)2N, CH3), (M-7069, Cl, H, F,哌啶-4 -基甲基，H), (Μ·7070, Cl, H, F,哌啶-4-基甲基，Cl), (M-7071, Cl, H, F,哌啶- 4-. 基甲基，F), (Μ·7〇72, Cl, H, F,哌啶-4 -基甲基；CF3), (M-7〇73, Cl，H, F, 哌啶-4 ·基甲基，Br), (M-7074, Cl, H, F,唬啶-4 -基甲基:，CH3), (M-7〇75, Cl, H, F,環己基甲基 I, Η), (M-7076, Cl, H, F,環己基甲基， Cl), (Μ·7077, Cl, H, F,環己基甲基，F), (M-7078, Cl, H, F, 環己基甲基，CF3), (M-7079, Cl, H, F,環己基甲基丨，Br), (M-7080, Cl, H, F，環己基甲基，CH3), (M-7081, Cl, H, Cl, Η, Η), (M-7082, Cl, H, Cl, H， Cl), (M-7083, Cl, H, Cl, H, F), (M-7084, Cl, H, Cl, H, CF3), (M-7085, Cl, H, Cl，H, Br), (M-7086, Cl, H, Cl, H, CH3), (M-7087, Cl, H, Cl, F, Η), (M-7088, Cl，H· Cl， F, Cl), (M-7089, Cl, H, Cl, F, F), (M-7090, Cl, H, Cl, F, CF3), (M-7091，Cl, H, Cl, F, Br), (M-7092, Cl, H, Cl, F，CH3), (M-7093, MeO, H, Cl, Cl, Η), (M-7094, Cl, H， Cl, Cl, Cl), (M-7095, Cl, H, Cl, Cl, F), (M-7096, Cl, H, Cl, Cl, CF3), (M-7097, Cl, H, Cl, Cl, Br), (M-7098, Cl, H, Cl, Cl, CH3), (M-7099, Cl, H, Cl, CHa, Η), (M-7100, Cl, H, Cl, CHs, Cl), (M-7101, Cl, H, Cl, CHs, F), (M-7102, Cl, H, Cl, CH3, CF3), (M-7103, Cl, H, Cl, CH3, Br), (M-7104, Cl, H, Cl, CH3, CH3), (M-7105, Cl， 208 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ---：----：--------- (請先閱讀背面之注意事項再填寫本頁) tr--------- 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明 H, Cl, Et, Η), (M-7106, Cl, H, Cl, Et, Cl), (M-7107, Cl, H, Cl, Et, F), (M-7108, Cl, H, Cl, Et, CFs), (M-7109, Cl, H, Cl, Et, Br), (M-7110, Cl, H, Cl, Et, CH3), (M-7111, Cl, H, Cl, n-Pr, Η), (M-7112, Cl, H, Cl, n-Pr, Cl), (M-7113, Cl, H, Cl, n-Pr, F), (M-7114, Cl, H, Cl, n-Pr, CF3>, (M-7115, Cl, H, Cl, n-Pr, Br), (M-7116, Cl， H, Cl, n-Pr, CHa), (M-7117, Gl, H, Cl, c-Pr, Η), (M-7118, Cl, H, Cl, c-Pr, Cl), (M-7119, Cl, H, Cl, c-Pr, F), (M-7120, Cl, H, Cl, c-Pr, CF3), (M-7121, Cl, H，Cl, c-Pr, Br), (M-7122, Cl, H，Cl, c-Pr, CH3), (M-7123, Cl, H, Cl, i-Pr，H)，（M-7124, Cl, H, Cl, i-Pr, Cl), (M-7125, Cl, H, Cl, i-Pr, F), (M-7126, Cl, H，Cl，i-Pr，CF3)， (M-7127, Cl, H, Cl, i-Pr，Br), (M-7128, Cl, H, Cl, i-Pr, CH3), (M-7129, Cl，H，Cl， η·Βιι, Η), (M-7130, Cl, H, Cl, n-Bu, Cl), (M-7131, Cl, H, Cl, n-Bu, F), (M-7132, Cl, H, Cl, n-Bu, CFs), (M-7133, Cl, H, Cl, n-Bu, Br), (M-7134, Cl, H, Cl, n-Bu, CH3), (M-7135, Cl, H, Cl, i-Bu, Η), (M-7136, Cl，H, Cl, i-Bu, Cl), (M-7137, Cl，H， Cl, i-Bu, F), (M-7138, Cl, H, Cl, i-Bu, CF3), (M-7139, Cl, H, Cl, i-Bu, Br), (M-7140, Cl, H, Cl, i-Bu, CH3), (M-7141, Cl, H, Cl, sec-Bu, Η), (M-7142, Cl, H，Cl, sec-Bu, Cl), (M-7143, Cl, H, Cl, sec-Bu, F), (M-7144, Cl, H, Cl, sec-Bu, CFa), (M-7145, Cl, H, Cl, sec-Bu, Br), (M-7146, Cl, H, Cl, sec-Bu, CHa), (M-7147, Cl, H, Cl, n-Pen, Η), (M-7148, Cl, H, Cl, n-Pen, Cl), (M-7149, Cl, H, Cl, n-Pen, F), (M-7150, Cl, H, Cl, n-Pen, CF3), (M-7151, Cl, H, Cl, n-Pen, Br), (M-7152, Cl, H, Cl, n-Pen, CH3), (M-7153, Cl, H, Cl, c-Pen, Η), (M-7154, Cl, H, Cl, c-Pen, Cl)， (M-7155, Cl, H, Cl, c-Pen，F), (M-7156, Cl, H, Cl, oPen, CF3)，（M-7157, Cl，H. Cl， c-Pen, Br), (M-7158, Cl, H, Cl，c-Pen, CH3), (M-7159, Cl, H, Cl, n-Hex，H)， (M-7160, Cl, H, Cl，n-Hex, Cl), (M-7161, Cl, H, Cl, n-Hex, F), (M-7162, Cl, H，Cl， n-Hex, CF3), (M-7163, Cl, H, Cl，n-Hex, Br), (M-7164, Cl, H，Cl，n-Hex，CH3)， (M-7165, Cl, H, Cl, c-Hex, Η), (M-7166, Cl，H, Cl, c-Hex, Cl), (M-7167, Cl，H，Cl， c-Hex, F), (M-7168, Cl, H, Cl, c-Hex, CF3), (M-7169, Cl, H, Cl, c-Hex, Br), (M-7170, Cl, H, Cl, c-Hex, CH3), (M-7171, Cl, H, Cl, OH, Η), (M-7172, Cl, H, Cl, OH, 209 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 丨丨：----：-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 ____B7 _______ 五、發明說明
Cl), (M-7173, Cl, H, Cl, OH, F), (M-7174, Cl, H, Cl, OH, CF3), (M-7175, Cl, H，Cl, OH, Br), (M-7176, Cl, H, Cl, OH, CH3), (M-7177, Cl, H, Cl, EtO, Η), (M-7178, Cl， H, Cl, EtO, Cl), (M-7179, Cl, H, Cl, EtO, F), (Μ·7180, Cl, H, Cl, EtO, CF3)， (M-7181, Cl, H, Cl, EtO, Br), (M-7182, Cl, H, Cl, EtO, CH3), (M-7183, Cl, H，Cl， n-PrO, Η), (M-7184, Cl, H, Cl, n-PrO, Cl), (M-7185, Cl, H, 01, n-PrO, F), (M-7186, Cl, H, Cl, n-PrO, CFs), (M-7187, Cl, H, Cl, n-PrO, Br), (M-7188, Cl, H, Cl, n-PrO, CHa), (M-7189, Cl, H, Cl, PhO, Η), (M-7190, Cl, H, Cl, PhO, Cl), (M-7191, Cl, H, Cl, PhO, F), (M-7192, Cl, H, Cl, PhO, CF3), (M-7193, Cl, H，Cl, PhO, Br)， (M-7194, Cl, H, Cl, PhO, CH3), (M-7195, Cl, H, Cl, BnO, Η), (M-7196, Cl, H，Cl, BnO, Cl), (M-7197, Cl, H, Cl, BnO, F), (M-7198, Cl, H, Cl, BnO, CF3), (M-7199, Cl, H, Cl, BnO, Br), (M-7200, Cl, H, Cl, BnO, CH3), (M-7201, Cl, H, Cl, PhCH2CH2〇, Η), (M-7202, Cl, H, Cl, PhCH2CH2〇, Cl), (M-7203, Cl, H, Cl, PhCH2CH2〇, F), (M-7204, Cl, H, Cl, PhCH2CH2〇, CFa)，（M-7205, Cl, H, Cl, PhCH2CH2〇, Br), (M-7206, Cl, H, Cl, PhCH2CH2〇, CH3), (M-7207, Cl, H, Cl, CF3〇, Η), (M-7208, Cl, H, Cl, CFsO, Cl), (M-7209, Cl, H, Cl, CFaO, F), (M-7210, Cl, H, Cl, CFsO, CFs), (M-7211, Cl, H, Cl, CFaO, Br), (M-7212, Cl, H, Cl, CFaO, CH3), (M-7213, Cl, H, Cl, Ph, Η), (M-7214, Cl, H, Cl, Ph, Cl), (M-7215, Gl，H, Cl， Ph, F), (M-7216, Cl, H, Cl, Ph, CFa), (M-7217, Cl, H, Cl, Ph, Br), (M-7218, Cl, H, Cl, Ph, CHs), (M-7219, Cl, H, Cl, 4-F-Ph, Η), (M-7220, Cl, H, Cl, 4-F-Ph, Cl), (M-7221, Cl, H, Cl, 4-F-Ph, F), (M-7222, Cl, H, Cl, 4-F.Ph, CF3)，（M-7223, Cl, II· Cl, 4-F-Ph, Br), (M-7224, Cl, H, Cl, 4-F-Ph, CH3), (M-7225, Cl, H, Cl, 4-CF3-Ph， Η), (M-7226, Cl, H, Cl, 4-CF3-Ph, Cl), (M-7227, Cl, H, Cl, 4-CF3-Ph，F)，（M-7228, Cl, H, Cl, 4-CF3-Ph, CF3), (M-7229, Cl, H, Cl, 4-CF3-Ph, Br), (M-7230, Cl，H, Cl, 4-CF3-Ph, CH3), (M-7231, Cl, H, Cl, 4-(Me)2N.Ph, H), (M-7232, Cl, H, Cl, 4-(Me)2N-Ph, Cl), (M-7233, Cl, H, Cl, 4-(Me)2N-Ph, F), (M-7234, Cl, H, Cl, 4-(Me)2N-Ph, CFa), (M-7235, Cl, H, Cl, 4-(Me)2N-Ph, Br), (M-7236, Cl, H, Cl, 4- 210 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） - ------- (請先閱讀背面之注意事項再填寫本頁) tr--------- 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 __B7_____ 五、發明說明 (Me)2N-Ph, CH3), (M-7237, Cl, H, Cl, 4-OH-Ph, Η), (M-7238, Cl, H, Cl，4-0H-Ph, Cl), (M-7239, Cl, H, Cl, 4-OH-Ph，F), (M-7240, Cl, H, Cl, 4-OH-Ph, CF3), (M-7241, Cl, H, Cl, 4-OH-Ph, Br), (M-7242, Cl，H, Cl, 4-OH-Ph, CH3), (Μ·7243, Cl, H, Cl, 3,4-di-F-Ph, Η), (M-7244, Cl, H, Cl, 3,4-di-F-Ph, Cl)，（M-7245, Cl, H， Cl, 3,4-di-F-Ph, F), (M-7246, Cl, H, Cl, 3,4-di.F-Ph, CFa), (M-7247, Cl, 11, Cl, 3,4-di-F-Ph, Br), (M-7248, Cl, H, Cl, 3,4-di-F-Ph, CHa), (M-7249, Cl, H, Cl, 4-COOH-Ph, Η), (M-7250, Cl, H, Cl, 4-COOH-Ph, Cl), (M-7251，Cl，H, Cl, 4-COOH-Ph, F), (M-7252, Cl, H, Cl, 4-COOH-Ph, CF3), (M-7253, Cl, H, Cl, 4-COOH-Ph, Br), (M-7254, Cl, H, Cl, 4-COOH-Ph, CH3), (M-7255, Cl, H, Cl，Bn， Η), (M-7256, Cl, H, Cl, Bn, Cl), (M-7257, Cl, H, Cl, Bn, F), (M-7258, Cl, H, Cl, Bn，CF3), (M-7259, Cl, H, Cl, Bn, Br), (M-7260, Cl, H，Cl, Bn, CH3)，（Μ·7261，Cl， H, Cl, 4-F-Bn, Η), (M-7262, Cl, H, Cl, 4-F-Bn, Cl), (M-7263, Cl, H，Cl, 4-F-Bn， F), (M-7264, Cl, H, Cl, 4-F-Bn, CFa)，（M-7265, Cl，H, Cl, 4-F-Bn, Br), (M-72G6, Cl, H, Cl, 4-F-Bn, CH3)，（M-7267, Cl, H, Cl, 2-Py, Η), (Μ·7268, Cl, H, Cl, 2-Py， Cl), (M-7269, Cl, H, Cl, 2-Py, F)，（M-7270, Cl, H, Cl, 2-Py, CF3), (M-7271, Cl，H， Cl, 2-Py, Br), (M-7272, Cl, H, Cl, 2-Py, CH3), (M-7273, Cl, H, Cl, 3-Py，H), (M-7274, Cl, H, Cl, 3-Py, Cl), (M-7275, Cl, H, Cl, 3-Py，F), (M-7276, Cl，H, Cl， 3-Py, CFa), (M-7277, Cl, H, Cl, 3-Py, Br), (M-7278, Cl, H, Cl, 3-Py, CHa), (M-7279, Cl, H, Cl, 4-Py, Η), (M-7280, Cl, H, Cl, 4-Py, Cl), (M-7281, Cl, H, Cl, 4-Py, F), (M-7282, Cl, H, Cl, 4-Py, CF3), (M-7283, Cl, H，Cl, 4-Py, Br), (M-7284, Cl, H, Cl, 4-Py, CH3), (M-7285, Cl, H, Cl, 2-Th, H>, (M-7286, Cl, H, Cl, 2-Th, Cl), (M-7287, Cl, H, Cl, 2-Th, F), (M-7288, Cl, H, Cl, 2-Th, CF3), (M-7289, Cl, H, Cl, 2-Th, Br)，（M-7290, Cl, H, Cl, 2-Th, CH3), (M-7291, Cl, H, Cl, 3-Th, Η), (M-7292, Cl, H, Cl, 3-Th, Cl), (M-7293, Cl, H, Cl, 3-Th, F), (M-7294, Cl, H, Cl, 3-Th, CF3), (M-7295, Cl, H, Cl, 3-Th, Br), (M-7296, Cl, H, Cl, 3-Th, CH3), (M-7297, Cl, H, Cl， 吡唑-2 -基 > Η), (M-7298, Cl, H，Cl,吡唑-2 -基，Cl), (M-7299, Cl, H, Cl， 211 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --：----1-------------β--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 _______B7_____ 五、發明說盟（^。） 吡嗤-2-基，F), (Κι·7300, Cl, H, C1，毗唑·2-基，CF3), (Μ·7301, Cl，H，Cl， 吡唤-2-基，Br), (μ·7302, Cl, H, Cl,吡唑-2-基，CH3), (M-7303, Cl, H, Cl, 吡嗤·3-基，Η), (M-7304, Cl, H, Cl,吡唑-3-基,Cl), (M-7305, Cl, H，Cl, 吡唑-3·基，F), (M-7306, Cl, H，Cl,吡唑·3·基· CF3), (M-7307, Cl, H, Cl, 吡唑-3-基· Br), (M-7308, Cl, 11, Cl,吡唑·3-基，Cih), (M-7iUn)，（几11,(儿 咳症-2-基，h>, (M-7310, Cl, H, Cl,嘧啶-2-基，C1), (M-7311, Cl, H, Cl， 嘛淀·2·基，F), (Μ·7312 ci, H, Cl,嘧啶-2·基，CF3), (M-7313, Cl, H，Cl， 嘧症·2·基，Br), (M-7314, Cl, H, Cl,嘧啶·2·基，CH3), (M-73 15, Cl, H， Cl,嘛啶-4-基，η), (M-7316, Cl, H, Cl,嘧啶-4-基，Cl), (M-7317, Cl，H， Cl,瞭啶-4-基，F), (M-7318, Cl, H, Cl,唪啶·4-基，CF3), (M-7319, Cl, H, Cl,嘛啶-4-基，Br), (M-7320, Cl, H, Cl,嘧啶-4-基,CH3), (1VI-7321，Cl， H, Cl,贿啶·5·基，Η), (M-7322, Cl, H, Cl,喃啶-5-基 〇 Cl), (M-7323, Cl， H，Cl,哺啶-5·基，f), (M-7324, Cl, H, Cl,贿啶-5-基，pF3), (M-7325, Cl, H, Cl,嘧啶-5·基，Br), (μ·7326, Cl, H, Cl,啼啶-5·基，CH3), (M-7327, Cl, H, Cl, HOOCCH2CH2CH2, Η), (M-7328, Cl, H, Cl, HOOCCH2CH2CH2, Cl), (M-7329, Cl, H, Cl, HOOCCH2CH2CH2, F), (M-7330, Cl, H, Cl, HOOCCH2CH2CH2, CFs), (M-7331, Cl, H, Cl, HOOCCH2CH2CH2, Br), (M-7332, Cl, H, Cl, HOOCCH2CH2CH2, CHa), (M-7333, Cl, H, Cl, HOOCCH2CH2CH2CH2, Η), (M-7334, Cl, H, Cl, HOOCCH2CH2CH2CH2, Cl), (M-7335, Cl, H, Cl, HOOCCH2CH2CH2CH2, F), (M-7336, Cl, H, Cl, HOOCCH2CH2CH2CH2, CF3), (M-7337, Cl, H, Cl, HOOCCH2CH2CH2CH2, Br), (M-7338, Cl, H, Cl, HOOCCH2CH2CH2CH2, CH3)y (M-7339, Cl, H, Cl, (Me)2NCOCH2CH2CH2CH2， Η), (M-7340, Cl, H, Cl, (Me)2NCOCH2CH2CH2CH2, Cl), (M-7341，Cl, H, Cl, (Me)2NCOCH2CH2CH2CH2, F), (M-7342, Cl, H, Cl, (Me)2NCOCH2CH2CH2CH2r CF3), (M-7343, Cl, H, Cl, (Me)2NCOCH2CH2CH2CH2, Br), (M-7344, Cl, H, Cl, (Me)2NCOCH2CH2CH2CH2, CH3), (M-7345, Cl, H, Cl, 212 ^紙張尺度適用中國國家標準（CNS)A4規格（210>< 297公釐） --^----Γ I I I I----I---^訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五 經濟部智慧財產局員工消費合作社印製 (請先閱讀背面之注意事項再填寫本頁) (Jl]Si^^H(2CH2(^H2CH2CH2, Η), (M-7346, Cl, H，Cl, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-7347, Cl, H, Cl, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-7348, Cl, H, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-7349, Cl, H, Cl, (Me)2NCOCH2CH2CH2OH2Cll2, Ur), (M.7350, Cl, II, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CHa), (M-7351, Cl, H, Cl, MeOCH2, Η), (M· 7352, Cl, H, Cl, MeOCH2, Cl), (M-7353, Cl, H, Cl, MeOCH2, F), (M-7354, Cl, H, Cl, MeOCH2, CF3), (M-7355, Cl, H, Cl, MeOCH2, Br), (M-7356, Cl, H, Cl， MeOCH2, CHa), (M-7357, Cl, H, Cl, EtOCH2, Η), (M-7358, Cl, H, Cl, EtOCH2,
Cl), (M-7359, Cl, H, Cl, EtOCH2, F), (M-7360, Cl, H, Cl, EtOCH2, CF3), (M-7361， Cl, H, Cl, EtOCH2, Br), (M-7362, Cl, H, Cl, EtOCH2, CH3), (M-7363, Cl，H，Cl, EtOCH2CH2, Η), (M-7364, Cl, H, Cl, EtOCH2CH2, Cl), (M-7365, Cl, H, Cl， EtOCH2CH2, F), (M-7366, Cl, H, Cl, EtOCH2CH2, CFa), (M-7367, Cl, II, Cl EtOCH2CH2, Br), (M-7368, Cl, H, Cl, EtOCH2CH2, CH3), (M-7369, Cl, H, Cl， MeOCH2CH2〇CH2CH2, Η), (M-7370, Cl, H, Cl, MeOCH2CH2〇CH2CH2, Cl), (M-7371, Cl, H, Cl, MeOCH2CH2〇CH2CH2, F), (M-7372, Cl, H, Cl, MeOCH2CH2〇CH2CH2, CF3), (M-7373, Cl, H, Cl, MeOCH2CH2〇CH2CH2, Br)， (M-7374, Cl, H, Cl, MeOCH2CH2〇CH2CH2, CH3), (M-7375, Cl, H, Cl, MeOCH2CH2, Η), (M-7376, Cl, H, Cl, MeOCH2CH2, Cl), (M-7377, Cl，H, Cl, MeOCH2CH2, F), (M-7378, Cl, H, Cl, MeOCH2CH2, CF3), (M-7379, Cl, H，Cl， MeOCH2CH2, Br), (M:7380, Cl, H, Cl, MeOCH2CH2, CH3), (M-7381，Cl, H, Cl， HOCH2, Η), (M-7382, Cl, H, Cl, HOCH2, Cl), (M-7383, Cl, H, Cl, HOCH2, F)， (M-7384, Cl, H, Cl, HOCH2, CF3), (M-7385, Cl, H, Cl, HOCH2, Br), (M-7386, Cl, H, Cl, HOCH2, CHs), (M-7387, Cl, H, Cl, HOCH2CH2, Η), (M-7388, Cl, H, Cl, HOCH2CH2, Cl), (M-7389, Cl, H, Cl, HOCH2CH2, F), (M-7390, Cl, H, Cl, HOCH2CH2, CFa), (M-7391, Cl, H, Cl, HOCH2CH2, Br), (M-7392, Cl, H, Cl, 213 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 _____B7_ ;_ 五、發明說明η HOCH2CH2, CHa), (M-7393, Cl, H, Cl, HOCH2CH2CH2, Η), (M-7394, Cl, H, Cl, HOCH2CH2CH2, Cl), (M-7395, Cl, H, Cl, HOCH2CH2CH2, F), (M-7396, Cl, H, Cl, HOCH2CH2CH2, CFs), (M-7397, Cl, H, Cl, HOCH2CH2CH2, Br), (M-7398, Cl, H, Cl, HOCH2CH2CH2, CHa), (M-7399, Cl, H, Cl, HOCH2CH2CH2CH2, Η), (M-7400, Cl, H, Cl, HOCH2CH2CH2CH2, Cl), (M-7401, Cl, 11, Cl, 1100112〇112〇112〇112, F), (M-7402, Cl, H, Cl, HOCH2CH2CH2CH2, CFs), (M-7403, Cl, H, Cl, HOCH2CH2CH2CH2, Br), (M-7404, Cl, H, Cl, HOCH2CH2CH2CH2, CH3), (M-7405, Cl, H, Cl, HOCH2CH2CH2CH2CH2, Η), (M-7406, Cl, H, Cl, HOCH2CH2CH2CH2CH2, Cl), (M-7407, Cl, H, Cl, HOGH2CH2CH2CH2CH2, F), (M-7408, Cl, H, Cl, HOCH2CH2CH2CH2CH2, CFa), (M-7409, Cl, H, Cl, HOCH2CH2CH2CH2CH2, Br), (M-7410, Cl, H, Cl, HOCH2CH2CH2CH2CH2, CHa), (M-7411, Cl, H, Cl, HOCH2CH2OCH2CH2, Η), (M-7412, Cl, Ή, Cl, HOCH2CH2OCH2CH2, Cl), (M-7413, Cl, H, Cl, HOCH2CH2OCH2CII2, F), (M-7414, Cl, H, Cl, HOCH2CH2OGH2CH2, CF3), (M-7415, Cl, H, Cl, HOCH2CH2OCH2CH2, Br), (M-7416, Cl, H, Cl, HOCH2CH2OCH2CH2, CHa), (M-7417, Cl, H, Cl, (Me)2N, Η), (M-7418, Cl, H, Cl, (Me)2N, Cl), (M-7419, Cl, H, Cl, (Me)2N, F), (M-7420, Cl, H, Cl, (Me)2N, CFa), (M-7421, Cl, H, Cl, (Me)2N, Br), (M-7422, Cl, H, Cl, (Me)2N, CH3), (M-7423, Cl, H, Cl,哌啶-4 -基 甲基 1, Η), (M-7424, Cl, H, Cl,哌啶-4-基甲基，Cl), (M-7425, Cl，H，Cl， 哌啶-4 -基甲基，F), (M-7426, Cl, H, Cl,哌啶-4 -基甲棊，CF3)， (M-7427, Cl, H, Cl,哌啶-4-基甲基，Br), (M-7428, Cl, H, Cl,哌啶-4-棊甲基丨，CH3), (M-7429, Cl, H, Cl,環己基甲基，H)，（M-7430, Cl，H，Cl， 環己基甲基，Cl), (M-7431, C1, H, Cl,環己基甲基:，F),(M-7432，C1，H， Cl,環己基甲基，CF3)，（Μ·7433, Cl, H, Clj 環己基甲基，Br)，（Μ·7434, Cl, H, Cl,環己基甲基 I，CH3), (M-7435, Cl, F, Η, H，Η), (M-7436, Cl，F，Η, H, Cl>, (M-7437, Cl, F, Η, H，F), (M-7438, Cl, F, Η, H，CF3)，（M-7439, Cl，F，H， 214 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） —^-----------------訂--------- (請先閱讀背面之注意事項再填寫本頁) A7 1284639 _B7__ 五、發明說明（4) H, Br), (M-7440, Cl, F, Η, H, CH3)，（M-7441, Cl, F，H, F, Η), (M-7442, Cl, F，H， F, Cl), (M-7443, Cl, F, H, F, F), (M-7444, Cl, F, H, F, CF3), (M-7445, Cl，F, H, F, Br), (M-7446, Cl, F, H, F, CH3), (M-7447, Cl, F, H，Cl, Η), (M-7448, Cl，F, H，Cl， Cl), (Μ·7449, Cl, F, H, Cl, F), (M-7450, Cl，F, H, Cl, CF3), (M-7451, Cl, F, H, Cl， Br), (M-7452, Cl, F, II, Cl, Clla), (M-74C3, Cl, F, 11, Clia, Η), (M-7454, Cl, F, II, CH3, Cl), (M-7455, Cl, F, H, CH3, F), (M-7456, Cl, F, H, CH3, CF3), (M-7457, Cl, F, H, CH3, Br), (M-7458, Cl, F, H, CH3, CH3), (M-7459, Cl, F, H, Et, H)，（M-7460, Cl, F, H, Et, Cl), (M-7461, Cl, F, H, Et, F), (M-7462, Cl, F, H, Et，CF3)，（M-7463, Cl, F, H, Et, Br), (M-7464, Cl, F, H, Et, CHa), (M-7465, Cl, F, H, n-Pr, Η), (M-7466, Cl, F, H, n-Pr, Cl), (M-7467, Cl, F, H, n-Pr, F), (M-7468, Cl, F, H，n-Pr, CFa), (M-7469, Cl, F, H, n-Pr, Br), (M-7470, Cl, F, H, n-Pr, CHa), (M-7471, Cl, F, H, c-Pr, Η), (M-7472, Cl, F, H, c-Pr, Cl), (M-7473, Cl, F, H, c-Pr, F), (M-7474, Cl, F, H, c-Pr, CFa), (M-7475, Cl, F, H, c-Pr, Br), (M-7476, Cl, F, II, c-Pr, CII3), (M-7477, Cl, F, H, i-Pr, Η), (M-7478, Cl, F, H, i-Pr, Cl), (M-7479, Cl, F, H, i-Pr， F), (M-7480, Cl, F, H, i-Pr, CF3), (M-7481, Cl，F, H, i-Pr, Br), (M-7482, Cl, F，H， i-Pr, CH3), (M-7483, MeO, F，H, n-Bu, Η), (M-7484, Cl, F, H, n-Bu，Cl), (M-7485, Cl, F, H, n-Bu, F), (M-7486, Cl, F, H, n-Bu, CF3), (M-7487, Cl，F, H, n-Bu，Br)， (M-7488, Cl, F, H, n-Bu, CH3), (M-7489, Cl, F，H, i-Bu, Η), (M-7490, Cl，F，H， i-Bu, Cl), (M-7491, Cl, F, H, i-Bu, F), (M-7492, Cl, F, H, i-Bu, CF3), (M-7493, Cl, F, H, i-Bu, Br), (M-7494, Cl, F, H, i-Bu, CH3), (Μ-749Γ)，Cl, F，II，sec-Bu, H)· (M-7496, Cl, F, H, sec-Hu, Cl), (M-7497, Cl, F, H, sec-Bu, F), (M-7498, Cl, F, H, sec-Bu, CFa), (M-7499, Cl, F, H, sec-Bu, Br), (M-7500, Cl, F, H, sec-Bu, CHs), (M-7501, Cl, F, H, n-Pen, Η), (M-7502, Cl, F, H, n-Pen, Cl), (M-7503, Cl, F, H, n-Pen, F), (M-7504, Cl, F, H, n-Pen, CFs), (M-7505, Cl, F, H, n-Pen, Br), (M-7506, Cl, F, H, n-Pen, CH3), (M-7507, Cl, F, H, c-Pen, Η), (M-7508, Cl，F, H, c-Pen, Cl), (M-7509, Cl, F, H, c-Pen, F), (M-7510, Cl, F, H, c-Pen, CF3), (M-7511, 215 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐) ： --^----^-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 A7 1284639 _B7___ 五、發明說明（W4)
Cl, F, H, c-Pen, Br), (M-7512, Cl, F, H, c-Pen, CHa), (M-7613, Cl, F, H, n-Hex, Η), (M-7514, Cl, F, H, n-Hex, Cl), (M-7515, Cl, F, H, n-Hex, F), (M-7516, Cl, F, H, n-Hex, CF3), (M-7517, Cl, F, H, n-Hex, Br), (M-7518, Cl, F, H, n-Hex, CH3), (M-7519, Cl, F, H, c-Hex, Η), (M-7520, Cl, F, H, c-Hex, Cl), (M-7521, Cl, F，H， c-Hex, F), (M-7522, Cl, F, H, c-Hex, CFa), (M-7G23, Cl, F, li, e-llox, Hr), (M-7524, Cl, F, H, c-Hex, CH3), (M-7525, Cl, F, H, OH, Η), (M-7526, Cl, F, H, OH, Cl), (M-7527, Cl, F, H, OH, F), (M-7528, Cl, F, H, OH, CF3), (M-7529, Cl, F，H， OH, Br), (M-7530, Cl, F, H, OH, CH3), (M-7531, Cl，F，H，EtO, H)，（Μ·7532, Cl， F,H,EtO,Cl),(M-7533,Cl,F,H,EtO,F),(M-7534,Cl,F,H,EtO,CF3)，（M-7535, Cl, F, H, EtO, Br), (M-7536, Cl, F, H, EtO, CHs), (M-7537, Cl, F, H, n-PrO, Η), (M-7538, Cl, F, H, n-PrO, Cl), (M-7539, Cl, F, H, n-PrO, F), (M-7540, Cl, F, H, n-PrO, CFs), (M-7541, Clt F, H, n-PrO, Br), (M-7542, Cl, F, H, n-PrO, CH3), (M-7543, Cl, F, H, PhO, Η), (M-7544, Cl, F, H, PhO, Cl), (M-7545, Cl, F, II, PhO, F), (M-7546, Cl, F, H, PhO, CF3), (M-7547, Cl, F, H, PhO, Br), (M-7548, Cl, F, H, PhO, CH3), (M-7549, Cl, F, Η, BnO, Η), (M-7550, Cl, F, H, BnO, Cl), (Μ·7551, Cl, F, H, BnO, F), (M-7552, Cl, F, H, BnO, CF3), (M-7553, Cl, F, H, BnO, Br)，（M· 7554, Cl, F, H, BnO, CH3), (M-7555, Cl, F, H, PhCH2CH2〇, Η), (Μ·7556, Cl，F， H, PhCH2CH2〇, Cl), (M-7557, Cl, F, H, PI1CH2CH2O, F)，（M-7558, Cl, F，H， PhCH2CH2〇, CFa), (M-7559, Cl, F, H, PhCH2CH2〇, Br), (M-7560, Cl, F, H, PhCH2CH2〇, CHa), (M-7561, Cl, F, H, CFaO, Η), (M-7562, Cl, F, H, CFsO, Cl). (M-7563, Cl, F, H, CFsO, F), (M-7564, Cl, F, H, CFsO, CFa), (M-7565, Cl, F, H, CF3〇, Br), (M-7566, Cl, F, H, CF3〇, CH3), (M-7567, Cl, F, H, Ph, Η), (M-7568, Cl, F, H, Ph, Cl), (M-7569, Cl, F, H, Ph, F), (M-7570, Cl, F, H，Ph, CF3), (M-7571， Cl, F, H, Ph, Br), (M-7572, Cl，F, H, Ph, CH3>, (M-7573, Cl, F，H, 4-F-Ph，H)， (M-7574, Cl, F, H, 4-F-Ph, Cl), (M-7575, Cl, F, H, 4-F-Ph, F), (M-7576, Cl, F，H， 4-F-Ph, CF3), (M-7577, Cl，F, H, 4-F-Ph，Br)，（M-7578, Cl, F, H, 4-F-Ph，CHs)， 216 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --------------- (請先閱讀背面之注意事項再填寫本頁) 訂---- 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、發明說明（>ιτ) (請先閱讀背面之注意事項再填寫本頁)
ϋ ϋ n I 經濟部智慧財產局員工消費合作社印製 (Μ·7579, Cl, F, H, 4-CFa-Ph, Η), (M-7580, Cl, F, H，4-CF3-Ph，Cl), (Μ·7581，Cl, F, H, 4-CF3-Ph, F), (M-7582, Cl, F, H, 4-CFa-Ph, CF3), (M-7583, Cl, F, H, 4-CFa-Ph, Br), (M-7584, Cl, F, H, 4.CF3-Ph, CHa), (M-7585, Cl, F, H, 4-(Me)2N-Ph, H)，（M-7586, Cl, F, H, 4-(Me)2N-Ph, Cl), (M-7587, Cl, F, H, 4-(Me)2N-Ph, F), (M-7588, Cl, F, II, 4-(Me)2N*Ph, CFa), (M-7G89, Cl, F, II, 4-(Mo)2N.Ph, Br), (M-7590, Cl, F, H, 4-(Me)2N-Ph, CH3), (M-7591, Cl, F, H, 4-OH-Ph, Η), (M-7592, Cl, F, H, 4-OH-Ph, Cl), (M-7593, Cl, F, H, 4-OH-Ph, F), (M-7594, Cl, F, H, 4-OH-Ph, CF3), (M-7595, Cl, F, H, 4-OH-Ph, Br), (M-7596, Cl, F, H，4-OII-Ph， CH3), (M-7597, Cl, F, H, 3,4-di-F-Ph, Η), (M-7598, Cl, F, H, 3,4-di-F-Ph，Cl)， (M-7599,Cl，F,H,3,4-di-F-Ph,F),(M-7600,Cl,F,H,3,4-di-F-Ph,CF3),(M· 7601, Cl, F, H, 3,4-di-F-Ph, Br), (M-7602, Cl, F, H, 3,4-di-F-Ph, CH3)，（M-7603, Cl, F, H, 4-COOH-Ph, Η), (M-7604, Cl, F, H, 4-COOH-Ph, Cl), (M-7605, Cl, F，H, 4-COOH-Ph, F), (M-7606, Cl, F, H, 4-COOH-Ph, CF3), (M-7G07, Cl，F, H, 4-COOH-Ph, Br), (M-7608, Cl, F, H, 4-COOH-Ph, CH3), (M-7609, Cl, F, H, Bn, H)， (M-7610, Cl, F, H, Bn, Cl), (M-7611, Cl, F, H, Bn, F), (M-7612, Cl, F, H, Bn，CF3)， (M-7613,Cl,F,H,Bn,Br),(M-7614,Cl,F,H,Bn,CH3),(M-7615,Cl,F,H,4· F-Bn, Η), (M-7616, Cl, F, H, 4-F-Bn, Cl)，（M-7617, Cl, F, H, 4-F-Bn，F), (M-7618, Cl, F, H, 4-F-Bn, CF3), (M-7619, Cl, F, H, 4-F-Bn，Br), (M-7620, Cl, F, H, 4-F· Bn，CH3), (M-7621, Cl, F, H, 2-Py, Η), (M-7622, Cl, F，H, 2-Py, Cl), (M-7623, Cl， F，H, 2-Py, F), (M-7624, Cl, F, H, 2-Py, CF3), (Μ·7625, Cl, F，H, 2-Py，Br)， (M-7626, Cl, F, H, 2-Py: CH3), (M-7627, Cl, F, H, 3-Py, Η), (M-7628, Cl，F, H， •3-Py, Cl), (M-7629, Cl, F, H，3-Py，F), (M-7630, Cl, F, H，3-Py, CF3)，（Μ·7631，Cl， F，H, 3-Py，Br), (M-7632, Cl, F, H, 3-Py, CH3), (M-7633, Cl, F，H, 4-Py，H)， (M-7634, Cl, F, H, 4-Py, Cl), (M-7635, Cl, F, H, 4-Py, F), (M-7636, Cl, F, H, 4-Py, CF3), (M-7637, Cl, F, H, 4-Py，Br), (M-7638, Cl, F，H, 4-Py, CHs), (M-7639, Cl, F, H, 2-Th, Η), (M-7640, Cl, F, H, 2-Th, Cl), (M-7641, Cl, F, H, 2-Th, F), 217 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ， A7 1284639 ___ B7 _ 五、發明說明（>▲) (M-7642, Cl, F, H, 2-Th, CFs), (M-7643, Cl, F, H, 2-Th, Br), (M-7644, Cl, F, H, 2-Th, CH3), (M-7645, Cl, F, H, 3-Th, Η), (M-7646, Cl, F, H, 3-Th，Cl), (M-7647, Cl, F, H, 3-Th, F), (M-7648, Cl, F, H, 3-Th, CFa), (M-7649, Cl, F, H, 3-Th, Br), (M-7650, Cl, F, H, 3-Th, CH3), (M-7651, Cl, F, H,吡唑-2-基，Η), (M-7652, Cl, F, H,吡唑-2-基，Cl)，（Μ·70(33, Gl, F, U,吡唑-2-碁，F)，II， (ft 嗤·2·基，CF3), (M-7655, Cl, F, H,壯嗤-2-基，Br)，（M-7656, Cl, F，H， Ift 唑-2·基，CH3), (M-7657, C1，F, H,壯哇-3-基，Η), (M-7658, C1，F，H，
Ift 嗅-3-基★ Cl), (M-7659, Cl, F, H,砒唑-3·基· F)，(M-7660, Cl, F，H, 吡唑·3·基，CF3), (M-7661, Cl, F, H,吡唑-3-基，Br), (M-7662, C1，F，H, 唆-3-基，CH3), (M-7663, Cl, F，H,嘧啶-2-基，Η), (M-7664, Cl, F, H, 嘧啶-2·基，Cl), (M-7665, Cl, F, H,嘧啶-2_基，F), (M-7666, Cl，F, H, 嘧啶-2·基，CF3), (M-7667, Cl, F, H 嘧陡-2-基，Br), (Μ·7668, Cl, F，H, 嘧淀·2-基，CH3), (M-7669, Cl, F, II,嘧陡-4-基，11),(1^7(}70，（：1，[^11, 嘧啶·4·基，Cl), (M-7671, Cl, F, H,嘧啶-4-基，F), (Μ·7672, Cl, F, H, 嘧啶-4·基，CF3), (M-7673, Cl, F, H,嘧啶-4-基，Br), (M-7674, Cl, F, H， 嘧啶-4-基，CH3), (M-7675, Cl, F, H,嘧啶-5-基，Η), (M-7676, Cl，F, H， 嘧啶·5·基，Cl), (M-7677, Cl, F, H,嘧啶·5-基，F), (M-7678, Cl, F, H， 嘧啶-5·基，CF3>,(M-7679, Cl, F, H,嘧啶-5-基，Br), (M-7680, Cl, F，H， 喊啶-5·基，CH3), (M-7681，Cl，F, H, HOOCCH2CH2CH2, Η), (M-7682, Cl，F， H, HOOCCH2CH2CH2, Cl), (M-7683, Cl, F, H, HOOCCH2CH2CH2, F), (M-7684. Cl, F, H, HOOCCH2CFT2CH2, CFa), (M-7685, Cl, F, H, HOOCCH2CH2CH2, Br), (M-7686, Cl, F, H, HOOCCH2CH2CH2, CHa), (M-7687, Cl, F, H, HOOCCH2CH2CH2CH2, Η), (M-7688, Cl, F，H, HOOCCH2CII2CH2CH2, Cl), (M-7689, Cl, F, H, HOOCCH2CH2CH2CH2, F), (M-7690, Cl, F, H, HOOCCH2CH2CH2CH2, CF3), (M-7691, Cl, F, H, HOOCCH2CH2CH2CH2, Br), (M-7692, Cl, F, H, HOOCCH2CH2CH2CH2, CHs), (M-7693, Cl, F, H, 218 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ---r---.-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 A7 1284639 _B7___ 五、發明說明（ (Me)2NCOCH2CH2CH2CH2, Η), (Μ-7694, Cl, F，H, (Me)2NCOCH2CH2CH2CH2， Cl), (M-7695, Cl, F, H, (Me)2NCOCH2CH2CH2CH2, F), (M-7696, Cl, F，Η, (Me)2NCOCH2CH2CH2CH2, CF3), (M-7697, Cl, F, H, (Me)2NCOCH2CH2CH2CH2, Br), (M-7698, Cl, F, H, (Me)2NCOCH2CH2CH2CH2, CH3), (M-7699, Cl，F, H， (Me)2NCOCH2CH2CH2CH2CU2, II), (M-7700, Cl, K, II, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-7701, Cl, F, H, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-7702, Cl, F, H, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-7703, Cl, F，H, (Me)2NCOCH2CH2CH2CH2CH2, Br), (Μ·7704, Cl, F，H, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-7705, Cl, F, H, MeOCH2, Η), (M-7706, Cl, F, H, MeOCH2, Cl), (M-7707, Cl, F, H, MeOCH2, F), (M-7708, Cl, F, H， MeOCH2, CF3), (M-7709, Cl, F, H, MeOCH2, Br), (Μ·7710, Cl, F，H, MeOCH2， CHa), (M-7711, Cl, F, H, EtOCH2, Η), (M-7712, Cl, F, H, EtOCII2, Cl), (M-7713, Cl, F, H, EtOCH2, F), (M-7714, Cl, F, H, EtOCHb, CF3), (M-7715, Cl, F, H, EtOCH2, Br), (M-7716, Cl, F, H, EtOCH2, CH3), (M-7717, Cl, F, H, EtOCH2CH2, Η), (M-7718, Cl, F, H, EtOCH2CH2, Cl), (M-7719, Cl, F, H，EtOCH2CH2, F)， (M-7720, Cl, F, H, EtOCH2CH2, CF3), (M-7721, Cl, F，H, EtOCH2CH2, Br)， (M-7722, Cl, F, H, EtOCH2CH2, CH3), (M-7723, Cl, F, H，MeOCH2CH2〇CH2CH2, Η), (M-7724, Cl, F, H, MeOCH2CH2〇CH2CH2, Cl), (M-7725, Cl, F, H, MeOCH2CH2〇CH2CH2, F), (M-7726, Cl, F, H, MeOCH2CH2〇CH2CH2, CF3)， (M-7727, Cl, F, H，MeOCH2CH2〇CH2CH2, Br>, (M-7728, Cl，F，H， MeOCH2CH2〇CH2CH2, CH3), (M-7729, Cl, F, H, MeOCH2CH2, H>, (M-7730, Cl， F, H, MeOCH2CH2, Cl), (M-7731, Cl, F, H, MeOCH2CH2, F), (M-7732, Cl，F，H· MeOCH2CH2, CF3), (M-7733, Cl，F, H, MeOCH2CH2, Br), (M-7734, Cl, F，H， MeOCH2CH2, CHa), (M-7735, Cl, F, H, HOCH2, Η), (M-7736, Cl, F, H, HOCH2, Cl), (M-7737, Cl, F, H, HOCH2, F>, (M-7738, Cl, F, H, HOCH2, CF3), (M-7739, Cl, 219 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公爱Ί ： --K----.-------------^--------- (請先閱讀背面之注音？事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明（“Ο F, H, HOCH2, Br), (M-7740, Cl, F, H, HOCH2, CHa), (M-7741, Cl, F, H, HOCH2CH2, Η), (M-7742, Cl, F, H, HOCH2CH2, Cl), (M-7743, Cl, F, H, HOCH2CH2, F), (M-7744, Cl, F, H, HOCH2CH2, CFa), (M-7745, Cl, F, H, HOCH2CH2, Br), (M-7746, Cl, F, H, HOCH2CH2, CHs), (M-7747, Cl, F, H, HOCH2CH2CH2, Η), (M-7748, Cl, F, II, HOCH2CII2CU2, Cl), (M-7741), 01, F, 11, HOCH2CH2CH2, F), (M-7750, Cl, F, H, HOCH2CH2CH2, CF3), (M-7751, Cl, F, H, HOCH2CH2CH2, Br), (M-7752, Cl, F, H, HOCH2CH2CH2, CHa), (M-7753, Cl, F, H, HOCH2CH2CH2CH2, Η), (M-7754, Cl, F, H, HOCH2CH2CH2CII2, Cl), (M-7755, Cl, F, H, HOCH2CH2CH2CH2, F), (M-7756, Cl, F, H, HOCH2CH2CH2CH2. CF3), (M-7757, Cl, F, H, HOCH2CH2CH2CH2, Br), (M-7758, Cl, F, H, HOCH2CH2CH2CH2, CH3), (Μ·7759, Cl, F, H, HOCH2CH2CH2CH2CH2, H), (M-7760, Cl, F, H, HOCH2CH2CH2CH2CH2, Cl), (M-7761, Cl, F, H, HOCH2CH2CH2CH2CH2, F), (M-7762, Cl, F, H, HOGH2CH2CH2CH2CH2, CF3), (M-7763, Cl, F, H, HOCH2CH2CH2CH2CH2, Br), (M-7764, Cl, F, H, HOCH2CH2CH2CH2CH2, CH3), (M-7765, Cl, F, H, HOCH2CH2OCH2CH2, H), (M-7766, Cl, F, H, HOCH2CH2OCH2CH2, Cl), (M-7767, Cl, F, H, HOCH2CH2OCH2CH2, F), (M-7768, Cl, F, H, HOCH2CH2OCH2CH2, CFa), (M-7769, Cl, F, H, HOCH2CH2OCH2CH2, Br), (M-7770, Cl, F, H, HOCH2CH2OCH2CH2, CH3), (M-7771, Cl, F, H, (Me)2N, Η), (M-7772, Cl, F, H, (Me)2N, Cl), (M-7773, Cl, F, H, (Me)2N, F), (M-7774, Cl, F, H, (Me)2N，CF3), (M-7775, Cl, F, H, (MehN, Br), (M-7776, Cl, F, H, (Me)2N, CH3), (M-7777, Cl，F， H，哌啶-4 基甲基，Η), (M-7778, Cl, F, H,哌啶 4 -基甲基，Cl), (M-7779, Cl, F，H，哌啶· 4 _ 基甲基，F), (M-7780, Cl, F, H,哌啶-4 -基甲基，CF3), (M-7781, Cl, F, H,哌啶-4-基甲基，Br), (M-7782, Cl, F， H,.哌啶-4-基申基，CH3), (M-7783, Cl, F, H,環己基甲基|,11),(河· 7784, Cl, F, H,環己基甲基，Cl), (Μ·7785, Cl, F, H,環己基甲基，F), 220 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公爱Υ "" •---*----I----· I I I (請先閱讀背面之注意事項再填寫本頁) 訂---------線赢 1284639 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明（4) (M-7786, Cl, F, H,環己基甲基丨，CF3), (M-7787, Cl, F, H,環己基甲基， Br), (M-7788, Cl, F, H,環己基甲基，（^3),(1^-7789,(：1,卩，[,1^出，（]^· 7790,C1,F,F,H,C1),(M-7791,C1,F,F,H,F)，（M-7792，C1，F,F，H,CF3)，（M-7793, Cl, F, F, H, Br), (M-7794, Cl, F, F, H, CH3), (M-7795, Cl, F, F, F, H), (M-7796, Cl, F, F, F, Cl), (M-7797, Cl, F, F, F, F), (M-7798, Cl, F, F, F, CFa), (M-7799, Cl, F, F, F, Br), (M-7800, Cl, F, F, F, CH3), (M-7801, Cl, F，F，Cl, H), (M-7802, Cl，F, F, Cl, Cl), (M-7803, Cl, F, F, Cl, F)，（M-7804, Cl, F，F，Cl，CF3)， (M-7805, Cl, F, F, Cl, Br), (M-7806, Cl, F, F, Cl, CII3), (M-7807, Cl, F, F, CII3, Η), (M-7808, Cl, F, F, CH3, Cl), (M-7809, Cl, F, F, CH3, F), (M-7810, Cl, F, F， CH3, CF3), (M-7811, Cl, F, F, CH3, Br), (M-7812, Cl，F，F, CH3, CH3), (M-7813, Cl, F, F, Et, Η), (M-7814, Cl, F, F, Et, Cl), (M-7815, Cl, F，F, Et, F), (M-7816, Cl， F, F, Et, CF3), (M-7817, Cl, F, F，Et, Br), (M-7818, Cl, F，F，Et，CH3)，（M-7819, Cl, F, F, n-Pr, Η), (M-7820, Cl, F, F, n-Pr, Cl), (M-7821, Cl, F, F, n-Pr, F). (M-7822, Cl, F, F, n-Pr, CF3), (M-7823, Cl, F, F, n-Pr, Br), (M-7824, Cl, F，F, n-Pr，CH3), (M-7825, Cl, F, F, c-Pr, Η), (M-7826, Cl, F, F，c-Pr, Cl), (M-7827, Cl, F，F, c-Pr, F), (M-7828, Cl, F, F, c-Pr, CF3), (M-7829, Cl, F, F, c-Pr, Br), (M-7830, Cl, F, F, c-Pr, CH3), (M-7831, Cl, F, F, i-Pr, Η), (M-7832, Cl, F, F, i-Pr, Cl), (M-7833, Cl, F, F, i-Pr, F), (M-7834, Cl, F, F, i-Pr，CF3), (M-7835, Cl，F，F，i-Pr， Br), (M-7836, Cl, F, F, i-Pr, CHs), (M-7837, Cl, F, F，n-Bu，Η), (M-7838, Cl，F，F， n-Bu, Cl)，（M-7839, Cl，F, F, n-Bu，F)，（M-7_, Cl, F, F, n-Bu，CF3)，（M-7841, Cl，F, F, n-Bu, Br), (M-7842, Cl, F, F, n-Bu, CH3), (M-7843, Cl, F, F, i-Bu, H)， (M-7844, Cl, F, F, i-Bu, Cl)，（M-7845, Cl, F, F，i-Bu，F), (M-7846, Cl, F, F, i-Bu， CF3), (M-7847, Cl, F, F, i-Bu, Br), (M-7848, Cl, F, F, i-Bu, CH3), (M-7849, Cl, F, F, sec-Bu, Η), (M-7850, Cl, F, F, sec-Bu, Cl), (M-7851, Cl, F, F, sec-Bu, F), (M-7852, Cl, F, F, sec-Bu, CF3), (M-7853, Cl, F, F, sec-Bu, Br), (M-7854, Cl，F， F, sec-Bu, CH3), (M-7855, Cl, F, F, n-Pen, Η), (M-7856, Cl，F, F，n-Pen, Cl)， 221 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ： (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 _______ B7 五、發明說明卜h ) (M-7857, Cl，F, F, n pen F) (μ·7858, ci, F, F，n-Pen, CF3), (M-7859, Cl, F，F, n.pen, Br), (M-786〇, Cl, F, F, n-Pen, CH3), (M-7861, Cl, F, F, c-Pen, Η), (M-7862, Cl, F，F, c.i>en ci>, (M-7863, Cl, F, F, c-Pen, F), (M-7864, Cl, F, F，c-Pen, CF3>，（M-7865, Cl, F F C-Pen, Br), (μ·7866, Cl, F, F, c-Pen, CH3)，（M-7867, Cl, F, F, n-Hex, Η), (M-7868, Cl, F, F, n-Hex, Cl), (M-7869, Cl, F, F, n-llox, F), (M-7870, Cl, F, F, n-Hex cf3), (M-7871, Cl, F, F, n-Hex，Br)，（M-7872, CL F, F, n-Hex, CHs), (M-7873, Cl, F, F, c-Hex, Η), (M-7874, Cl, F, F, c-Hex, Cl), (M-7875, Cl, F, F, c-Hex, F), (M-7876, Cl, F, F, c-Hex, CFa), (M-7877, Cl, F, F, c-Hex, Br), (M-7878, Cl, F, F, c-Hex, CH3), (M-7879, Cl, F, F, OH, Η), (M-7880, Cl， F, F, OH, Cl), (Μ·7881, Cl, F, F, OH, F), (M-7882, Cl, F, F, OH，CF3), (M-7883, Cl, F, F, OH, Br>, (M-7884, Cl, F, F, OH, CH3), (M-7885, Cl, F, F, EtO, H), (M-7886, Cl, F, F, EtO, Cl), (M-7887, Cl, F, F, EtO, F), (Μ·7888, Cl, F，F, EtO, CF3), (M-7889, Cl, F, F, EtO, Br), (M-7890, Cl，F, F, EtO, CH3), (M-7891, Cl, F， F, n-PrO, Η), (M-7892, Cl, F, F, n-PrO, Cl), (M-7893, Cl, F, F, n-PrO, F), (M-7894, Cl, F, F, n-PrO, CF3), (M-7895, Cl, F, F, n-PrO, Br), (M-7896, Cl, F，F， n-PrO, CH3), (Μ·7897, Cl, F, F, PhO, Η), (M-7898, Cl, F, F, PhO, Cl), (M-7899, Cl, F, F，PhO, F), (M-7900, Cl, F, F, PhO, CF3), (M-7901, Cl, F, F, PhO, Br)， (Μ·7902, Cl, F, F, PhO, CH3), (M-7903, Cl, F, F, BnO, Η), (M-7904, Cl，F, F, BnO, Cl), (M-7905, Cl, F, F, BnO, F), (M-7906, Cl, F, F, BnO, CF3), (M-7907, Cl, F, F，BnO, Br), (M-7908, Cl, F, F, BnO, CH3), (Μ·7909, Cl, F, F, PhCH2CH2〇, Η), (M-7910, Cl, F, F, PhCH2CH2〇, Cl), (M-7911, Cl, F, F, PhCH2CH2〇, F), (M-7912, Cl, F, F, PhCH2CH2〇, CF3), (M-7913, Cl, F, F, PI1CH2CH2O, Br), (M-7914, Cl, F, F，PhCH2CH2〇, CH3), (M-7915, Cl，F, F, CF3〇, H)，（M-791G, Cl, F, F, CF3O, Cl), (M-7917, Cl, F, F, CFsO, F), (M-7918, Cl, F, F, CFsO, CF3), (M-7919, Cl, F, F, CFaO, Br), (M-7920, Cl, F, F, CFnO, CHa), 01, F, F,
Ph, Η), (M-7922, Cl, F, F, Ph, Cl), (M-7923, Cl, F, F, Ph, F), (M-7924, Cl, F, F, 222 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ----r-----------------訂--------- (請先閱讀背面之注意事項再填寫本頁) A7 1284639 ___B7 _ 五、發明說明（一）
Ph, CF3), (M-7925, Cl, F, F, Ph, Br), (M-7926, Cl，F, F, Ph，CH3), (M-7927, Cl，F， F, 4-F-Ph, Η), (M-7928, Cl, F, F, 4-F-Ph, Cl), (M-7929, Cl，F, F，4-F-Ph, F)， (M-7930, Cl, F, F, 4-F-Ph, CF3), (M-7931, Cl, F, F, 4-F-Ph, Br)，（Μ·7932, Cl，F， F，4-F-Ph, CH3), (M-7933, Cl, F, F, 4-CF3-Ph, Η), (M-7934, Cl, F, F, 4-CF3-P1i， Cl), (M-7936, Cl, F, F, 4-CF3-Ph, F), (M-793G, Cl, F, F, 4.CF3-IM1, (M-7〇a7,
Cl, F, F, 4-CF3-Ph, Br), (M-7938, Cl, F, F, 4-CF3-Ph, CHs), (M-7939, Cl, F, F, 4-(Me)2N-Ph,H),(M-7940,Cl,F,F,4-(Me)2N-Ph,Cl),(M-7941,Cl,F，F，4-(Me)2N-Ph,F),(M-7942，Cl,F,F,4-(Me)2N-Ph,CF3),(M-7943,Cl,F,F，4-(Me)2N-Ph,Br),(M-7944,Cl,F,F,4-(Me)2N-Ph,CH3),(M-7945，Cl,F，F，4-OH-Ph, Η), (M-7946, Cl, F, F, 4-OH-Ph, Cl)，（M-7947, Cl, F, F, 4-OH-Ph，F)， (M-7948, Cl, F, F, 4-OH-Ph, CF3), (M-7949, Cl, F, F, 4-OH-Ph, Br), (M-7950, Cl， F, F, 4-OH-Ph, CH3), (M-7951, Cl, F, F, 3,4-di-F-Ph，Η), (M-7952, Cl，F，F, 3,4-di-F.Ph, Cl), (M-7953, Cl, F, F, 3,4-di.F-Ph, F), (M-7954, Cl, F, F, 3,4-di-F-Ph, CF3), (M-7955, Cl, F, F, 3,4-di-F-Ph, Br), (M-7956, Cl, F, F, 3,4-di-F-Ph, CH3), (M-7957, Cl, F, F, 4-COOH-Ph, Η), (M-7958, Cl, F, F, 4-COOH-Ph, Cl)， (M-7959,Cl,F,F,4-COOH-Ph,F),(M-7960,Cl,F,F,4-COOH-Ph,CF3)，（M· 7961, Cl, F, F, 4-COOH-Ph, Br), (M-7962, Cl，F, F，4-COOH-Ph，CH3)，（M-7963, Cl, F, F, Bn, Η), (M-7964, Cl, F, F, Bn, Cl), (M-7965, Cl, F, Bn, F), (M-7966, Cl, F, F, Bn, CF3), (M-7967, Cl, F, F, Bn, Br), (M-7968, Cl, F, F, Bn, CH3), (M-7969, Cl, F, F, 4-F-Bn, Η), (M-7970, Cl, F, F, 4-F-Bn, Cl), (M-7971，Cl, F, F， 4-F-Bn, F), (M-7972, F, F, 4-F-Bn, CF3), (M-7973, Cl，F，F，4-F-Bn，Br)， (M-7974, Cl，F, F, 4-F-Bn, CH3), (M-7975, Cl, F, F, 2-Py, Η), (M-7976, Cl, F, F， 2-Py, Cl), (M-7977, Cl, F, F, 2-Py, F), (M-7978, Cl, F, F, 2-Py, CF3)，（M-7979, Cl， F,F,2-Py,Br),(M-7980,Cl,F,F,2-Py,CH3),(M-7981,Cl，F,F，3-Py,H)，（M-7982, Cl, F, F, 3-Py, Cl), (M-7983, Cl, F, F, 3-Py, F), (M-7984, Cl，F, F, 3-Py， CF3), (M-7985, Cl, F, F, 3-Py, Br), (M-7986, Cl, F, F，3-Py, CH3)，（M-7987, Cl, F， 223 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） —j----：-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 Λ7 A7 B7 五、發明說明（>») F, 4-Py, Η), (M-7988, Cl, F, F, 4-Py, Cl), (M-7989, Cl, F, F, 4-Py, F), (M-7990, Cl, F, F, 4-Py, CF3), (M-7991, Cl, F, F, 4-Py, Br), (M-7992, Cl, F, F, 4-Py, CH3), (M-7993, Cl, F, F, 2-Th, Η), (M-7994, Cl, F, F, 2-Th, Cl), (M-7995, Cl, F, F, 2-Th, F), (M-7996, Cl, F, F, 2-Th, CFs), (M-7997, Cl, F, F, 2-Th, Br), (M-7998, Cl, F, F, 2-Th, CHs), (M-7999, Cl, F, F, 3-Th, H), (M-80()0, Cl, K, F, 3-Th, Cl), (M-8001, Cl, F, F, 3-Th, F), (M-8002, Cl, F, F, 3-Th, CF3), (M-8003, Cl, F, F, 3-Th, Br), (M-8004, Cl, F, F, 3-Th, CH3), (M-8005, Cl, F, F,吡唑-2-基，Η), (M-8006, Cl, F, F,吡唑-2 -基,Cl), (M-8007, Cl, F, F,吡唑 2 -基，F)，（M-8008, Cl, F, F,吡唑·2·基，CF3), (M-8009, Cl, F, F,吡唑基，Br), (M-8010, Cl，F, F， 吡唑-2·基，CH3), (M-8011, Cl, F, F,吡唑-3-基，Η), (M-8012, Cl, F, F， 吡唑-3-基> Cl), (M-8013, Cl, F, F,吡唑-3-基· F), (M-8014, Cl，F, F，
Ift 唑-3·基，CF3), (M-8015, Cl, F, F,吡唑-3-基，Br), (M-8016, Cl, F, F, lift 唑-3-基，CH3), (M-8017, Cl, F, F,嘧啶-2-基，Η), (M-8018, Cl, F, F, 嘧啶-2·基，Cl), (M-8019, Cl, F, F,嘧啶-2-基，F)，（M-8020, Cl, F, F, 嘧啶·2·基丨，CF3), (M-8021, Cl, F, F,嘧啶·2·基，Br)，（M-8022, Cl, F，F， 嘧啶·2·基，CH3), (M_8023, Cl, F, F,嘧啶·4·基，Η), (Μ·8024, Cl, F, F， 嘧啶·4·基，Cl), (M-8025, Cl，F, F,嘧啶-4·基，F), (M-8026, Cl, F, F, 嘧啶-4-基，CF3), (M-8027, Cl, F, F,嘧啶-4-基，Br), (Μ·8028, Cl, F，F， 嘧啶-4-基 ’ CH3), (M-8029, Cl, F, F,嘧啶-5-基，Η), (M-8030, Cl，F, F， 嘧啶·5-基，Cl), (M-8031, Cl, F, F,嘧啶-5 -基，F), (M-8032, Cl, F，F， 嘧啶·5·基，CF3), (M-8033, Cl, F, F,嘧啶-5-基，Br), (M-8034, Cl, F，F， 嘧啶-5-基，CH3), (M-8035, Cl, F, F, HOOCCH2CH2CH2, H)，（M-8036, Cl, F， F, HOOCCH2CH2CH2, Cl), (M-8037, Cl, F, F, HOOCCH2CH2CH2, F), (M-8038, Cl, F, F, HOOCCH2CH2CH2, CF3), (M-8039, Cl, F, F, HOOCCH2CH2CH2, Br), (M-8040, Cl, F, F, HOOCCH2CH2CH2, CHa), (M-8041, Cl, F, F, HOOCCH2CH2CH2CH2, Η), (M-8042, Cl, F, F, HOOCCH2CH2CH2CH2, Cl), 224 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） I I l· I I L----- (請先閱讀背面之注意事項再填寫本頁) 訂--- 經濟部智慧財產局員工消費合作社印製 A7 1284639 _B7___ 五、發明說明（Η ) (M-8043, Cl, F, F, HOOCCH2CH2CH2CH2, F), (M-8044, Cl, F, F, HOOCCH2CH2CH2CH2, CFs), (M-8045, Cl, F, F, HOOCCH2CH2CH2CH2, Br), (M-8046, Cl, F, F, HOOCCH2CH2CH2CH2, CHa), (M-8047, Cl, F, F, (Me)2NCOCH2CH2CH2CH2, Η), (M-8048, Cl, F，F, (Me)2NCOCH2CH2CH2CH2， Cl), (M-8049, Cl, F, F, (Μθ)2ΝΟΟΟΗ2〇Η2〇Η2〇Η2, F), (M-8050, Cl, F, F, (Me)2NCOCH2CH2CH2CH2, CF3), (M-8051, Cl, F, F, (Me)2NCOCH2CH2CH2CH2, Br), (M-8052, Cl, F, F, (Me)2NCOCH2CH2CH2CH2, CH3), (M-8053, Cl，F，F, (Me)2NCOCH2CH2CH2CH2CH2, H)，（M-8054, Cl, F, F, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-8055, Cl, F, F, (Me)2NCOCH2CH2CH2CH2CH2, F), (Μ·8056, Cl, F, F, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-8057, Cl, F, F, (Me)2NCOCH2CH2CH2CH2CH2, Br), (Μ·8058, Cl, F, F, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-8059, Cl, F, F, MeOCH2, Η), (M-8060, Cl, F, F, MeOCH2, Cl), (M-8061, Cl, F, F, MeOCH2, F), (M-8062, Cl, F, F, MeOCH2, CF3), (M-8063, Cl, F, F, MeOCH2, Br), (M-8064, Cl, F, F, MeOCH2, CH3), (M-8065, Cl, F, F, EtOCH2, Η), (M-8066, Cl, F, F, EtOCFh, Cl)，（M-8067, Cl, F, F, EtOCH2, F), (M-8068, Cl, F, F, EtOCH2, CF3), (M-8069, Cl，F, F, EtOCH2, Br), (M-8070, Cl, F, F, EtOCH2, CH3), (M-8071, Cl, F, F, EtOCH2CH2, Η), (Μ·8072, Cl, F, F, EtOCH2CH2, Cl), (M-8073, Cl, F, F, EtOCH2CH2, F)， (M-8074, Cl, F, F, EtOCH2CH2, CF3), (M-8075, Cl, F，F，EtOCH2CH2, Br)，（M-8076, Cl, F, F, EtOCH2CH2, CH3), (M-8077, Cl, F，F, MeOCH2CIi2〇CIl2CH2, H), (M-8078, Cl, F, F, MeOCH2CH2〇CH2CH2, Cl), (M-8079, Cl，F，F， MeOCH2CH2〇CH2CH2, F), (M-8080, Cl, F, F, MeOCH2CH2〇CH2CH2, CF3), (M-8081, Cl, F, F, MeOCH2CH2〇CH2CH2, Br), (M-8082, Cl，F, F， MeOCH2CH2〇CH2CH2, CH3), (M-8083, Cl, F, F, MeOCH2CH2, Η), (M-8084, Cl， F，F，MeOCH2CH2, Cl), (M-8085, Cl, F，F, MeOCH2CH2, F), (M-8086, Cl，F，F， 225 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ---：-----------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、發明說明 (請先閱讀背面之注音心事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製
MeOCH2CH2, CFs), (M-8087, Cl, F, F, MeOCH2CH2, Br), (M-8088, Cl, F, F, MeOCH2CH2, CH3), (M-8089, Cl, F, F, HOCH2, Η), (M-8090, Cl, F，F，HOCH2, Cl), (M-8091, Cl, F, F, HOCH2, F), (M-8092, Cl, F, F, HOCH2, CFa), (M-8093, Cl, F, F, HOCH2, Br), (M-8094, Cl, F, F, HOCH2, CH3), (M-8095, Cl, F, F， HOCH2CH2, Η), (M-8096, Cl, F, F, IlOCJIaCliQ, 01), (M-HOS)?, 01, K, ΙΛ HOCH2CH2, F), (M-8098, Cl, F, F, HOCH2CH2, CF3), (M-8099, Cl, F, F, HOCH2CH2, Br), (M-8100, Cl, F, F, HOCH2CH2, CH3), (M_8101, Cl，F，F, HOCH2CH2CH2, Η), (M-8102, Cl, F, F, HOCH2CH2CH2, Cl)，（M-8103, Cl，F，F， HOCH2CH2CH2, F), (M-8104, Cl, F, F, HOCH2CH2CH2, CF3), (M-8105, Cl, F，F. HOCH2CH2CH2, Br), (M-8106, Cl, F, F, HOCH2CH2CH2, CHs), (M-8107, Cl, F, F, HOCH2CH2CH2CH2, Η), (M-8108, Cl, F, F, HOGH2CH2CH2CH2, Cl), (M-8109, Cl, F, F, HOCH2CH2CH2CH2, F), (M-8110, Cl, F, F, HOCH2CH2CH2CH2, CF3), (M-8111, Cl, F, F, HOCH2CH2CH2CH2, Br), (M-8112, Cl, F, F, HOCH2CH2CH2CH2, CHs), (M-8113, Cl, F, F, HOCH2CH2CH2CH2CH2, Η), (M-8114, Cl, F, F, HOCH2CH2CH2CH2CH2, Cl), (M-8115, Cl, F, F, HOCH2CH2CH2CH2CH2, F), (M-8116, Cl, F, F, HOCH2CH2CH2CH2CH2, CFs), (M-8117, Cl, F, F, HOCH2CH2CH2CH2CH2, Br), (M-8118, Cl, F, F, HOCH2CH2CH2CH2CH2, CH3), (M-8119, Cl, F, F, HOCH2CH2OCH2CH2, H), (M-8120, Cl, F, F, HOCH2CH2OCH2CH2, Cl), (M-8121, Cl, F, F, HOCH2CH2OCH2CH2, F), (M-8122, Cl, F, F, HOCH2GH2OCH2CH2, CFa), (M-8123, Cl, F, F, HOCH2CH2OCH2CH2, Br), (M-8124, Cl, F, F, HOCH2CH2OCH2CH2, CH3), (M-8125, Cl, F, F, (Me)2N, Η), (Μ·8126, Cl, F, F， (Me)2N, Cl), (M-8127, Cl, F, F, (Me)2N, F), (M-8128, Cl, F，F, (Me)2N，CF3)， (M-8129, Cl，F, F, (Me)2N, Br), (M-8130, Cl, F, F, (Me)2N, CH3), (M-8131, Cl，F， F,哌啶-4 -基甲基，Η), (M-8132, Cl, F, F,哌啶-4 -基甲基，Cl)， (M-8133, Cl, F, F,哌啶· 4 -基甲基，F)，(M-8134, Cl, F, F，piperidin-4-yl- 226 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公爱） 1284639 A7 _B7_ 五、發明說明（〜0 < + 廿甘 methyl, CF3), (M-8135, Cl, F, F,哌啶-4 -基甲基 9 Br), (M-8136, Cl，F, F, (請先閱讀背面之注意事項再填寫本頁) 哌啶-4 -基甲基;，CH3), (Μ-βΙ37, Cl, F, F,環己基甲基，Η), (Μ·8138, Cl, F, F, c環己基甲基，Cl), (M-8139, Cl, F, F,環己塞甲碁.F), (Μ· 8140，C1，F,F,環己基甲基，CF3), (M-8141, Cl, F, F,環己基甲基，：6〇, (M-8142, Cl, F, F,環己基甲基，Cih), (M-8143, Cl, F, Gl, li, U), (M-8144, Cl, F, Cl，H, Cl), (M-8145, Cl, F，Cl, H, F), (M-8146, Cl, F, Cl, H, CF3), (M-8147,
Cl, F, Cl, H, Br), (M-8148, Cl, F, Cl, H, CHa), (M-8149, Cl, F, Cl, F, Η), (M-8150,
Cl, F, Cl, F, Cl), (M-8151, Cl, F, Cl, F, F), (M-8152, Cl, F, Cl, F, CF3), (M-8153,
Cl, F, Cl, F, Br), (M-8154, Cl, F, Cl, F, CH3), (M-8155, Cl, F, Cl, Cl, H)，（M-815G, 經濟部智慧財產局員工消費合阼Fi中製
Cl, F, Cl, Cl, Cl), (M-8157, Cl, F, Cl, Cl, F), (M-8158, Cl, F, Cl, Cl, CF3), (M-8159, Cl, F, Cl, Cl, Br), (M-8160, Cl, F, Cl, Cl, CH3), (M-8161, Cl, F, Cl, CHs, H), (M-8162, Cl, F, Cl, CHs, Cl), (M-8163, Cl, F, Cl, CHa, F), (M-8164, Cl, F, Cl, CHa, CF3), (M-8165, Cl, F, Cl, CHa, Br), (M-8166, Cl, F, Cl, CHa, CH3), (M-8167, Cl, F，Cl, Et, Η), (M-8168, Cl, F, Cl, Et, Cl), (M-8169, Cl, F, Cl, Et, F)，（Μ·8170, Cl, F, Cl, Et, CF3), (M-8171, Cl, F, Cl, Et, Br), (M-8172, Cl, F，Cl，Et，CH3), (M-8173, Cl, F, Cl, n-Pr, Η), (M-8174, Cl, F, Cl, n-Pr, Cl), (M-8175, Cl, F, Cl, n-Pr, F), (M-8176, Cl, F, Cl, n-Pr, CF3)，（M-8177, Cl, F, Cl, n-Pr, Br), (M-8178, Cl, F, Cl， n-Pr, CHs), (M-8179, Cl, F, Cl, c-Pr, Η), (M-8180, Cl, F, Cl, c-Pr, Cl), (M-8181, Cl, F, Cl, c-Pr, F), (M-8182, Cl, F, Cl, c-Pr, CFa), (M-8183, Cl, F, Cl, c-Pr, Br), (M-8184, Cl, F, Cl, c-Pr, CH3), (M-8185, Cl, F, Cl, i-Pr, Η), (M-8186, Cl, F，CL i-Pr, Cl), (M-8187, Cl, F； Cl, i-Pr, F), (M-8188, Cl, F, Cl, i-Pr, CFs), (M-8189, Cl, F, Cl, i-Pr, Br), (M-8190, Cl, F, Cl, i-Pr, CH3), (Μ·8191, Cl, F, Cl, n-Bu，H)， (M-8192, Cl, F，Cl, n-Bu，Cl), (M-8193, Cl, F, Cl，n-Bu, F), (M-8194, Cl，F，Cl， n-Bu,CF3)，（M-8195,Cl,F,Cl，n-Bu，Br),(M-8196,Cl,F,Cl,n-Bu，CH3)，（M-8197, Cl, F, Cl, i-Bu, Η), (M-8198, Cl, F, Cl, i-Bu, Cl), (M-8199, Cl, F, Cl, i-Bu, F), (M-8200, Cl, F, Cl, i-Bu, CF3), (M-8201, Cl, F, Cl, i-Bu, Br)，（M-8202, Cl, F， 227 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 29>公釐) " 1284639 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明（>4)
Ql i-Bu, CHa), (M-8203, Cl, F, Cl, sec-Bu, Η), (M-8204, Cl, F, Cl, sec-Bu, Cl), (M^8205, Cl, F, Cl, sec-Bu, F), (M-8206, Cl, F, Cl, sec-Bu, CF3), (M-8207, Cl, F, cl, gec-Bu, Br), (M-8208, Cl, F, Cl, sec-Bu, CH3), (M-8209, Cl, F, Cl, n-Pen, H), (M-8210, Cl, F, Cl, n-Pen, Cl), (M-8211, Cl, F, Cl, n-Pen, F), (M-8212, Cl, F, Cl. n.Pen, CF3), (M-8213, Cl, F, Cl, n-Pen, Br), (M-8214, Ci, F, Cl, n-Pen, CHa), (M-8215, Cl, F, Cl, c-Pen, Η), (M-8216, Cl, F, Cl, c-Pen, Cl), (M-8217, Cl, F, Cl. c-Pen, F), (M-8218, Cl, F, Cl, c-Pen, CFa), (M-8219, Cl, F, Cl, c-Pen, Br), (M- 8220, Cl, F, Cl, c-Pen, CH3), (M-8221, Cl, F, Cl, n-Hex, Η), (M-8222, Cl, F，Cl， n-Hex, Cl), (M-8223, Cl, F, Cl, n-Hex, F), (M-8224, Cl, F, Cl, n-Hex, CFs), (M-8225, Cl, F, Cl, n-Hex, Br), (M-8226, Cl, F, Cl, n-Hex, CH3), (M-8227, Cl, F, Cl, c-Hex, Η), (M-8228, Cl, F, Cl, c-Hex, Cl), (M-8229, Cl, F, Cl, c-Hex, F)，（M-8230, Cl, F, Cl, c-Hex, CF3), (Μ·8231, Cl, F, Cl, c-Hex, Br), (M-8232, Cl，F, Cl，c-Hex， CHs), (M-8233, Cl, F, Cl, OH, Η), (M-8234, Cl, F, Cl, OH, Cl), (M-8235, Cl, F, Cl, OH, F), (M-8236, Cl, F, Cl, OH, CF3), (M-8237, Cl, F, Cl, OH, Br); (M-8238, Cl, F, Cl, OH, CHs), (M-8239, Cl, F, Cl, EtO, Η), (M-8240, Cl, F, Cl, EtO, Cl), (M- 8241, Cl, F, Cl, EtO, F), (Μ·8242, Cl, F, Cl, EtO, CF3), (M-8243, Cl, F, Cl, EtO, Br), (M-8244, Cl, F, Cl, EtO, CH3), (M-8245, Cl, F, Cl, n-PrO, Η), (M-8246, Cl， F, Cl, n-PrO, Cl), (M-8247, Cl, F, Cl, n-PrO, F), (M-8248, Cl, F, Cl, n-PrO, CFa), (M-8249, Cl, F, Cl, n-PrO, Br), (M-8250, Cl, F, Cl, n-PrO, CH3), (M-8251, Cl，F,
Cl, PhO, Η), (M-8252, Cl, F, Cl, PhO, Cl), (M-8253, Cl, F, Cl, PhO, F), (M-8254, Cl, F, Cl, PhO, CF3), (M-8255, Cl, F, Cl, PhO, Br), (M-8256, Cl, F, Cl, PhO, CHs), (M-8257, Cl, F, Cl, BnO, Η), (M-8258, Cl, F, Cl, BnO, Cl), (M-8259, Cl, F，Cl， BnO, F), (M-8260, Cl, F, Cl, BnO, CF3), (M-8261, Cl, F, Cl，BnO, Br)，（M-8262, Cl, F，Cl, BnO, CH3), (M-8263, Cl, F, Cl, PhCH2CH2〇, Η), (Μ·82(34, Cl, F，Cl， PhCH2CH2〇, Cl), (M-8265, Cl, F, Cl, PhCH2CH2〇, F), (M-8266, Cl，F，Cl， PhCH2CH2〇, CF3), (M-8267, Cl, F, Cl, PhCH2CH2〇, Br), (M-8268, Cl, F, Cl, 228 ___ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ^ --U------------------^--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五、發明說明（W) (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製
PhCH2CH2〇, CHa), (M-8269, Cl, F, Cl, CF3〇, Η), (M-8270, Cl, F, Cl, CFaO, Cl), (M-8271, Cl, F, Cl, CF3〇, F)，（M-8272, Cl, F, Cl, CF3〇, CF3), (M-8273, Cl, F, Cl， CFsO, Br), (M-8274, Cl, F, Cl, CF3〇, CHs), (M-8275, Cl, F, Cl, Ph, Η), (M-8276, Cl, F, Cl, Ph, Cl), (M-8277, Cl, F, Cl, Ph, F), (M-8278, Cl, F, Cl, Ph, CFs), (M-8279, Cl, F, Cl, Ph, Br), (M-8280, Cl, F, Cl, Ph, Cll：〇, (M.8281, Cl, ΙΛ Cl, 4-K-Ph，Η), (M-8282, Cl, F, Cl, 4-F-Ph, Cl), (M-8283, Cl, F, Cl, 4-F-Ph, F), (M-8284, Cl,F,Cl，4-F-Ph,CF3),(M-8285，Cl,F,Cl，4-F-Ph,Br)，（M-828G，Cl，F，Cl，4· F-Ph, CH3), (M-8287, Cl, F, Cl, 4-CF3-Ph, Η), (M-8288, Cl, F，Cl, 4-CF3-Ph，Cl)， (M-8289, Cl, F, Cl, 4-CF3-Ph, F), (M-8290, Cl, F, Cl, 4-CF3-Ph, CF3)，（M-8291， Cl, F, Cl, 4-CF3-Ph, Br), (M-8292, Cl, F, Cl, 4-CF3-Ph, CH3), (M-8293, Cl，F，Cl, 4-(Me)2N-Ph, Η), (M-8294, Cl, F, Cl, 4.(Me)2N-Ph, Cl), (M-8295, Cl, F, Cl, 4-(Me)2N-Ph, F), (M-8296, Cl, F, Cl, 4-(Me)2N-Ph, CF3), (M-8297, Cl, F, Cl, 4-(Me)2N-Ph, Br), (M-8298, Cl, F, Cl, 4-(Me)2N-Ph, CH3), (M-8299, Cl, F, Cl, 4-OH-Ph, Η), (M-8300, Cl, F, Cl, 4-OH-Ph, Cl), (M-8301, Cl, F, Cl, 4-OH-Ph, F), (M-8302, Cl, F, Cl, 4-OH-Ph, CF3), (M-8303, Cl, F, Cl, 4-OH-Ph, Br)，（M-8304, Cl, F, Cl, 4-OH-Ph, CH3), (M-8305, Cl, F, Cl, 3,4-di-F-Ph, Η), (M-8306, Cl, F，Cl， 3,4-di-F.Ph, Cl), (M-8307, Cl, F, Cl, 3,4-di-F-Ph, F), (M-8308, Cl, F, Cl, 3,4-di-F-Ph, CF3), (M-8309, Cl, F, Cl, 3,4-di-F-Ph, Br), (M-8310, Cl, F, Cl, 3,4-di-F-Ph, CHs), (M-8311, Cl, F, Cl, 4-COOH-Ph, Η), (M-8312, Cl, F, Cl, 4-COOH-Ph, Cl), (M-8313, Cl, F, Cl, 4-COOH-Ph, F), (M-8314, Cl, F, Cl, 4-COOH-Ph, CF3), (M-8315, Cl, F, Cl, 4-COOH-Ph, Br), (M-8316, Cl, F, Cl, 4-COOH-Ph, CH3), (M-8317, Cl, F, Cl, Bn, Η), (M-8318, Cl, F, Cl, Bn, Cl), (M-8319, Cl, F, Cl, Bn，F)，（M-8320, Cl, F, Cl, Bn，CF3), (M-8321, Cl, F, Cl, Bn, Br), (M-8322, CL F， Cl, Bn, CHs), (M-8323, Cl, F，Cl, 4-F-Bn, Η), (M-8324, Cl，F，Cl，4-F-Bii, Cl)， (M-8325, Cl, F, Cl, 4-F-Bn, F), (M-8326, Cl, F, Cl，4-F-Bn, CF3)，（M-8327, Cl, F， Cl, 4-F-Bn, Br)，（M-8328, Cl，F，Cl, 4-F-Bn, CH3), (M-8329, Cl，F, Cl，2-Py, H)， 229 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 1284639 A7 B7 五、發明說明（W) (M-8330, Cl, F, Cl, 2-Py, C1), (Μ·8331, Cl, F, Cl, 2-Py, F), (M-8332, Cl, F，C1, 2- Py, CFa), (M-8333, Cl, F, Cl, 2-Py, Br), (M-8334, Cl, F, Cl, 2-Py, CHa), (M-8335, Cl, F, Cl, 3-Py, Η), (M-8336, Cl, F, Cl, 3-Py, Cl), (M-8337, Cl, F, Cl, 3-Py, F), (M-8338, Cl, F, Cl, 3-Py, CFa), (M-8339, Cl, F, Cl, 3-Py, Br), (M-8340, Cl, F, Cl, 3-Py, CHa), (M-8341, Ci, F, Cl, 4-Py, Η), (M-8342, Cl, F, 01, 4-Py, Cl), (M-8343, Ci, F, Cl, 4-Py, F), (M-8344, Cl, F, Cl, 4-Py, CFa), (M-8345, Cl, F, Cl, 4-Py, Br), (M-8346, Cl, F, Cl, 4-Py, CHa), (M-8347, Cl, F, Cl, 2-Th, Η), (M-8348, Cl, F, Cl, 2-Th, Cl), (M-8349, Cl, F，Cl, 2-Th, F), (M-8350, Cl, F, Cl, 2-Th, CF3), (M-8351, Cl, F, Cl, 2-Th, Br), (M-8352, Cl, F, Cl, 2-Th, CH3), (M-8353, Cl, F，Cl， 3- Th, Η), (M-8354, Cl, F, Cl, 3-Th, Cl), (M-8355, Cl, F, Cl, 3-Th, F), (M-8356, Cl, F, Cl, 3-Th, CF3), (M-8357, Cl, F, Cl, 3-Th, Br), (M-8358, Cl, F, Cl, 3-Th, CH3)， (M-8359, Cl, F, Cl,吡唑-2-基7 Η), (M-8360, Cl, F, Cl,吡唑·2-基，Cl), (M-8361, Cl, F, Cl,吡唑·2-基，F), (M-8362, Cl, F, Cl,吡唑-2-基，CF3)， (M-8363, Cl, F, Cl,批唑-2·基，Br), (M-8364, Cl, F, Cl,吡唑·2·基，CH3)， (Μ·8365, Cl, F, Cl,吡唑-3-基，H), (M-8366, Cl，F, Cl,吡唑-3-基，Cl), (M-8367, Cl, F, Cl,吡唑·3·基，F)，（M-8368, Cl, F, Cl,吡唑-3-基，0卩3)， (Μ·8·369, Cl, F, Cl,吡唑-3·基，Br), (M-8370, Cl, F, Cl,吡唑-3-基，CH3), (M-8371, Cl, F, Cl,嘧啶·2-基，Η), (M-8372, Cl, F, Cl,嘧啶-2-基，Cl), (M-8373, Cl，F, Cl,嘧陡-2·基，F), (M-8374, Cl, F, Cl,嘧啶·2·基，CF3)， (M-8375, Cl，F, Cl，嘧啶·2·基，Br), (Μ·8376, Cl，F, Cl,嘧啶-2·基，CH3)， (M-8377, Cl, F, Cl,哺 -4·基，H), (M-8378, Cl, F, Cl,喃啶-心基!，Cl), (M-8379, Cl, F, Cl,嘛症·4·基，F), (M-8380, Cl, F, Cl,嘧啶·4-基，CF3)， (M-8381，Cl, F，Cl,嘧啶·4_基，Br), (M-8382, Cl, F, Cl,嘧啶-4-基，CH3)， (M-8383, Cl, F, Cl,嘧陡-5-基，Η), (M-8384, Cl，F, Cl,嘧啶-5-基，Cl)， (Μ·8385, Cl, F, Cl,嘧啶·5·基，F), (Μ·8386, Cl, F, Cl,嘧啶-5-基，CF3)， (M-8387, Cl，F, Cl,嘧啶-5 ·基、Br), (M-8388, Cl, F, Cl，嘧啶-5 -基，CH3)， 230 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ----1---'-------- (請先閱讀背面之注意事項再填寫本頁) 訂--- 經 濟 部 智 慧 財 產 局 員 工 消 費 合 作 社 印 製 經濟部智慧財產局員工消費合作社印製 1284639 A7 ____B7_ 五、發明說明卜”） (M-8389, Cl, F, Cl, HOOCCH2CH2CH2, Η), (M-8390, Cl, F, C1, HOOCCH2CH2CH2, Cl), (M-8391, Cl, F, Cl, HOOCCH2CH2CH2, F), (M-8392, C1, F, Cl, HOOCCH2CH2CH2, CF3), (M-8393, Cl, F, Cl, HOOCCH2CH2CH2, Br), (M-8394, Cl, F, Cl, HOOCCH2CH2CH2, CH3), (M-8395, Cl, F, Cl, HOOCCH2CH2CH2CH2, Η), (M-8396, Cl, F, Cl, IK)C)CCll2CII2Cll2Clla, Cl), (M-8397, Cl, F, Cl, HOOCCH2CH2CH2CH2, F), (M-8398, Cl, F, Cl, HOOCCH2CH2CH2CH2, CFa), (M-8399, Cl, F, Cl, HOOCCH2CH2CH2CH2, Br), (M-8400, Cl, F, Cl, HOOCCH2CH2CH2CH2, CHa), (M-8401, Cl, F, Cl, (Me)2NCOCH2CH2CH2CH2, Η), (M-8402, Cl, F, Cl, (Me)2NCOCH2CH2CH2CH2, Cl), (Μ·8403, Cl, F, Cl, (Me)2NCOCH2CH2CH2CH2, F), (M-8404, Cl, F, Cl, (Me)2NCOCH2CH2CH2CH2, CF3), (M-8405, Cl, F, Cl, (Me)2NCOCH2CH2CH2CH2, Br), (M-8406, Cl, F, Cl, (Me)2NCOCH2CH2CH2CH2, CH3>, (M-8407, Cl, F, CUMe)2NCOCH2CH2CH2CH2CH2, Η), (M-8408, Cl, F，Cl, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-8409, Cl, F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-8410, Cl, F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-8411, Cl, F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-8412, Cl，F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-8413, Cl, F, Cl, MeOCH2, H)，（M-8414, Cl, F, Cl, MeOCH2, Cl), (M-8415, Cl, F, Cl, MeOCH2, F), (M-8416, Cl, F，Cl， MeOCH2, CF3), (M-8417, Cl, F, Cl, MeOCH2, Br), (M-8418, Cl，F, Cl, MeOCH2, CHa), (M-8419, Cl, F, Cl, EtOCH2, Η), (M-8420, Cl, F, Cl, EtOCH2, Cl), (M-8421, Cl, F, Cl, EtOCH2, F), (M-8422, Cl, F, Cl, EtOCH2, CF3), (M-8423, Cl, F, Cl, EtOCH2, Br), (M-8424, Cl, F, Cl, EtOCH2, CHs), (M-8425, Cl, F, Cl, EtOCH2CH2, Η), (M-8426, Cl, F, Cl, EtOCH2CH2, Cl), (M-8427, Cl, F, Cl, EtOCH2CH2, F), (M-8428, Cl, F, Cl, EtOCH2CH2, CF3), (M-8429, Cl, F, Cl, EtOCH2CH2, Br), (M-8430, Cl, F, Cl, EtOGH2CH2, CHs), (M-8431, Cl, F, Cl, 231 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ----Γ---.-------------訂---------. (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五、發明說明（>〜） (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製
MeOCH2CH2〇CH2CH2, Η), (M-8432, Cl, F, Cl, MeOCH2CH2OCH2CH2, C1)， (M-8433, Cl, F, Cl, MeOCH2CH2〇CH2CH2, F), (M-8434, Cl, F, Cl， MeOCH2CH2〇CH2CH2, CF3), (M-8435, Cl, F, Cl, MeOCH2CH2〇CH2CH2, Br)， (M-8436, Cl, F, Cl, MeOCH2CH2〇CH2CH2, CH3), (M-8437, Cl，F，Cl, MeOCH2CH2, Η), (M-8438, Cl, F, Cl, Μθ001Ι20112, Cl), (M-8439, Cl, F, 〇L MeOCH2CH2, F), (M-8440, Cl, F, Cl, MeOCH2CH2, CF3), (M-8441, Cl, F, Cl, MeOCH2CH2, Br), (M-8442, Cl, F, Cl, MeOCH2CH2, CHa), (M-8443, Cl, F, Cl, HOCH2, Η), (M-8444, Cl, F, Cl, HOCH2, Cl), (M-8445, Cl, F, Cl, HOCH2, F), (M-8446, Cl, F, Cl, HOCH2, CF3), (M-8447, Cl, F, Cl, HOCH2, Br), (M-8448、CL F, Cl, HOCH2, CHa), (M-8449, Cl, F, Cl, HOCH2CH2, Η), (M-8450, Cl, F, Cl, HOCH2CH2, Cl), (M-8451, Cl, F, Cl, HOCH2CH2, F), (M-8452, Cl, F, Cl, HOCH2CH2, CF3), (M-8453, Cl, F, Cl, HOCH2CH2, Br), (M-8454, Cl, F, Cl, HOCH2CH2, CH3), (M-8455, Cl, F, Cl, HOCH2CH2CH2, Η), (M-8456, Cl，F，Cl, HOCH2CH2CH2, Cl), (M-8457, Cl, F, Cl, HOCH2CH2CH2, F), (M-8458, Cl, F, Cl, HOCH2CH2CH2, CFa), (M-8459, Cl, F, Cl, HOCH2CH2CH2, Br), (M-8460, Cl, F, Cl, HOCH2CH2CH2, CH3), (M-8461, Cl, F, Cl, HOCH2CH2CH2CH2, Η), (M-8462, Cl, F, Cl, HOCH2CH2CH2CH2, Cl), (M-8463, Cl, F, Cl, HOCH2CH2CH2CH2, F), (M-8464, Cl, F, Cl, HOCH2CH2CH2CH2, CFa), (M-8465, Cl, F, Cl, HOCH2CH2CH2CH2, Br), (M-8466, Cl, F, Cl, HOCH2CH2CH2CH2, CH3), (M-8467, Cl, F, Cl, HOCH2CH2CH2CH2CH2, Η), (M-8468, Cl, F, Cl, HOCH2CH2CH2CH2CH2, Cl), (M-8469, Cl, F, Cl, HOCH2CH2CH2CH2CH2, F), (M-8470, Cl, F, Cl, HOCH2CH2CH2CH2CH2, CF3), (M-8471, Cl, F, Cl HOCH2CH2CH2CH2CH2, Br), (M-8472, Cl, F, Cl, HOCH2CH2CH2CH2CH2, CH3), (M-8473, Cl, F, Cl, HOCH2CH2OCH2CH2, Η), (M-8474, Cl, F, Cl, HOCH2CH2OCH2CH2, Cl), (M-8475, Cl, F, Cl, HOCH2CH2OCH2CH2, F), (M-8476, Cl, F, Cl, HOCH2CH2OCH2CH2, CFa), (M-8477, Cl, F, Cl, 232 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（—I ) HOCH2CH2〇CH2CH2, Br), (M-8478, Cl, F, Cl, HOCH2CH2〇CH2CH2, CH3), (M-8479, Cl, F, Cl, (Me)2N, Η), (M-8480, Cl, F, Cl, (Me)2N, Cl), (M-8481, Cl, F， Cl, (Me)2N, F), (M-8482, Cl, F, Cl, (Me)2N, CF3), (M.8483, Cl, F, Cl, (Me)2N, Br)， (M-8484, Cl, F, Cl, (Me)2N, CH3), (M-8485, Cl, F, Cl,哌啶-4 -基甲基，H)， (M-8486, Cl, F, Cl,哌啶-4-基甲基，Cl), (M-8487, Cl, F, Cl，哌啶-4_ 基甲基，F), (M-8488, Cl, F, Cl,哌啶-4-基甲基，CF3)，（M-8489, Cl, F， Cl,哌啶-4 -基甲基!，Br), (M-8490, Cl, F, Cl,哌啶-4 -基甲基丨，CH3)， (M-8491, Cl, F, Cl,(環己基甲基，H), (M-8492, Cl，F, Cl,環己基甲基 L Cl), (M-8493, Cl，F, Cl，環己基甲棊丨，F)，（M-8494, Cl，F，Cl, 環己基甲基丨，CFO, (M-8495, Cl, F，Cl,環己基甲基，Br), (Μ·8496, Cl, F, Cl,環己基甲基 l, CH3), (M-8497, Cl, CH3, Η, Η, Η), (M-8498, Cl, CH3, H, H, Cl), (M-8499, Cl, CH3, Η, H, F), (M-8500, Cl, CH3, Η, H, CF3), (M-8501，Cl， CH3, Η, H, Br), (M-8502, Cl, CH3, Η, H, CH3), (M-8503, Cl，CH3, H, F，H)， (M-8504, Cl, CH3, H, F, Cl), (M-8505, Cl, CH3, H, F, F), (M-8506, Cl, CH3, H，F， CF3), (M-8507, Cl, CH3, H, F, Br), (M-8508, Cl, CH3, H，F, CH3)，（M-8509, Cl, CH3,H,C1,H),(M-8510,C1,CH3,H,C1,C1),(M-8511,C1,CH3,H,C1，F),(M-8512, Cl, CH3, H, Cl, CF3), (M-8513, Cl, CH3, H, Cl, Br), (M-8514, Cl, CH3, H, Cl， CH3), (M-8515, Cl, CH3, H, CH3, Η), (M-8516, Cl，CH3, H, CH3, Cl), (M-8517, Cl， CH3, H, CH3, F), (M-8518, Cl, CH3, H, CH3, CF3), (Μ·8519, Cl, CH3, H，CH3, Br)， (M-8520, Cl, CH3, H, CH3, CH3), (M-8521, Cl, CH3, H，Et, H)，（M-8522, Cl, CH3, H, Et, Cl), (M-8523, Cl, CH3, H, Et, F), (M-8524, Cl, CH3, H，Et, CF3)，（M-8525, Cl, CHa, H, Et, Br), (M-8526, Cl, CH3, H, Et, CHa), (M-8527, Cl, CHa, H, n-Pr, Η), (M-8528, Cl, CHa, H, n-Pr, Cl), (M-8529, Cl, CHa, H, n-Pr, F), (M-8530, Cl, CH3, H, n-Pr, CFa), (M-8531, Cl, CHa, H, n-Pr, Br), (M-8532, Cl, CHa, H, n-Pr, CHa), (M-8533, Cl, CHa, H, c-Pr, Η), (M-8534, Cl, CHa, H, c-Pr, Cl), (M-8535, Cl, CH3, H, c-Pr, F), (M-8536, Cl, CH3, H, c-Pr, CF3), (Μ·8537, Cl, CH3, H, c-Pr, Br), 233 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ： " --h----.-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明 (M-8538, Cl, CHs, H, c-Pr, CH3), (M-8539, Cl, CH3, H, i-Pr, Η), (M-8540, CL CH3, H, i-Pr, Cl), (M-8541, Cl, CH3, H, i-Pr, F), (M-8542, Cl, CH3, H, i-Pr，CF3)， (M-8543, Cl, CH3, H, i-Pr, Br), (M-8544, Cl, CH3, H, i-Pr, CH3), (M-8545, Cl， CH3, H, n-Bu, Η), (M-8546, Cl, CH3, H, n-Bu, Cl), (M-8547, Cl, CH3, Η, η·Βιι，F)， (M-8548, Cl, CHa, H, n-Bu, CFa), (M-8549, Cl, Ciia, H, n-Bu, Hr), (M-8550, CL CH3, H, n-Bu, CH3), (M-8551, Cl, CH3, H, i-Bu, Η), (M-8552, Cl, CH3, H，i-Bu, Cl), (M-8553, Cl, CH3, H, i-Bu, F), (M-8554, Cl, CH3, H, i-Bu, CF3), (M-8555, Cl， CHs, H, i-Bu, Br), (M-8556, Cl, CH3, H, i-Bu, CHa), (M-8557, Cl, CHa, H, sec-Bu, Η), (M-8558, Cl, CHs, H, sec-Bu, Cl), (M-8559, Cl, CHs, H, sec-Bu, F), (M-8560, Cl, CHa, H, sec-Bu, CFs), (M-8561, Cl, CHs, H, sec-Bu, Br), (M-8562, Cl, CH3, H, sec-Bu, CH3), (M-8563, Cl, CH3, H, n-Pen, Η), (M-8564, Cl，CH3, H， n-Pen, Cl), (M-8565, Cl, CH3, H, n-Pen, F), (M-8566, Cl, CHa, H, n-Pen, CFa), (M-8567, Cl, CHs, H, n-Pen, Br), (M-8568, Cl, CH3, H, n-Pen, CHa), (M-8569, Cl, CHs, H, c-Pen, Η), (M-8570, Cl, CH3, H, c-Pen, Cl), (M-8571, Cl, CH3, H, c-Pen, F), (M-8572, Cl, CH3, H, c-Pen, CFa), (M-8573, Cl, CHa, H, c-Pen, Br), (M-8574, Cl, CH3, H, c-Pen, CH3), (M-8575, Cl, CH3, H, n-Hex, Η), (M-8576, Cl, CH3, H, n-Hex, Cl), (M-8577, Cl, CHa, H, n-Hex, F), (M-8578, Cl, CH3, H, n-Hex, CFs), (M-8579, Cl, CH3, H, n-Hex, Br)，（M-8580, Cl, CH3, H, n-Hex, CH3), (M-8581，Cl， CH3, H, c-Hex, Η), (M-8582, Cl, CH3, H, c-Hex, Cl), (M-8583, Cl，CH3, H，c-Hex， F), (M-8584, Cl, CH3, H, c-Hex, CF3), (M-8585, Cl, CH3, H, c-Hex，Br), (M-8586, Cl, CHa, H, c-Hex, CHa), (M-8587, Cl, CHa, H, OH, Η), (M-8588, Cl, CHa, H, OH, Cl), (M-8589, Cl, CH3, H, OH, F), (M-8590, Cl, CH3, H, OH, CF3), (M-8591，Cl， CH3, H, OH, Br), (M-8592, Cl, CH3, H, OH, CH3), (M-8593, Cl, CH3, H，EtO, H)， (M-8594, Cl, CH3, H, EtO, Cl), (M-8595, Cl, CH3, H, EtO, F)，（M-8596, Cl，CHs， H，EtO, CF3), (M-8597, Cl, CH3, H, EtO, Br), (M-8598, Cl, CH3, H，EtO, CH3)， (M-8599, Cl，CH3, H，n-PrO, H), (M-8600, Cl，CH3, H，n-PrO, Cl), (M-8601，Cl, 234 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --------訂--- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五、發明說明（W ) (請先閱讀背面之注意事項再填寫本頁) CHa, H, n-PrO, F), (M-8602, Cl, CH3, H, n-PrO, CFa), (M-8603, Cl, CHa, H, n-PrO, Br), (M-8604, Cl, CH3, H, n-PrO, CH3), (M-8605, Cl, CH3, H, PhO, H), (M-8606, Cl, CHa, H, PhO, Cl), (M-8607, Cl, CHa, H, PhO, F), (M-8608, Cl, CH3, H，PhO, CF3), (M-8609, Cl, CH3, H, PhO, Br), (M-8610, Cl, CH3, H, PhO, CH3), (M-8611, Cl, CHa, Η, BnO, Η), (M-8612, Cl, CHa, II, BnO, Cl), (M-8013, Cl, Clla, H, BnO, F), (M-8614, Cl, CH3, H, BnO, CF3), (M-8615, Cl, CH3, H，BnO, Br), (M-8616, Cl, CH3, H, BnO, CH3), (M-8617, Cl, CH3, H, PhCH2CH2〇, Η), (M· 8618, Cl, CH3, H, PhCH2CH2〇, Cl), (M-8619, Cl, CH3, H, PhCH2CH2〇, F), (M-8620, Cl, CH3, H, PhCH2CH2〇, CF3), (M-8621, Cl, CH3, H, PhCH2CH2〇, Br)， (M-8622, Cl, CH3, H, PhCH2CH2〇, CH3), (M-8623, Cl, CH3, H, CF3〇, Η), (M-8624, Cl, CH3, H, CF3〇, Cl), (M-8625, Cl, CH3, H, CF3〇, F), (M-8626, Cl, CH3, 經濟部智慧財產局員工消費合作社印製 H, CF3O, CFs), (M-8627, Cl, CHs, H, CF3〇, Br), (M-8628, Cl, CH3, H, CFaO, CH3), (M-8629, Cl, CH3, H, Ph, Η), (M-8630, Cl, CH3, H, Ph, Cl), (M-8631, Cl, CH3, H, Ph, F), (M-8632, Cl, CHa, H, Ph, CFa), (M-8633, Cl, CHa, H, Ph, Br), (M-8634, Cl, CH3, H, Ph, CH3), (M-8635, Cl, CH3, H, 4-F-Ph, Η), (M-8636, Cl， CHa, H, 4-F-Ph, Cl), (M-8637, Cl, CHs, H, 4-F-Ph, F), (M-8638, Cl, CHa, H, 4-F-Ph, CF3), (M-8639, Cl, CH3, H, 4-F-Ph, Br), (M-8640, Cl, CH3, H, 4-F-Ph， CH3), (M-8641, Cl, CH3, H, 4-CF3-Ph, Η), (M-8642, Cl, CH3, H, 4-CF3-Ph，Cl)， (M-8643，Cl,CH3,H,4-CF3-Ph,F),(M-8644,Cl，CH3，H，4-CF3-Ph,CF3),(M· 8645, Cl, CH3, H, 4-CF3-Ph, Br), (M-8646, Cl，CH3, H，4-CF3-Ph, CH3), (M-8647, Cl, CH3, H, 4-(Me)2N-Pli, Η), (M-8648, Cl, CH3, H, 4-(Me)2N-Ph, Cl>, (M-8649, Cl, CH3, H, 4-(Me)2N-Ph, F), (M-8650, Cl, CH3, H, 4-(Me)2N-Ph, CF3), (M-8651, Cl, CH3, H, 4-(Me)2N-Ph, Br>, (M-8652, Cl, CH3, H，4-(Me)2N-Ph, CH3)，（M-8653, Cl, CH3, H, 4-OH-Ph, Η), (M-8654, Cl, CH3, H, 4-OH-Ph, Cl), (M-8655, Cl, CH3, H, 4-OH-Ph, F), (M-8656, Cl, CH3, H, 4-OH-Ph, CF3), (M-8657, Cl, CH3, H， 4-OH-Ph, Br), (Μ·8658, Cl，CH3, H, 4-OH-Ph, CH3), (M-8659, Cl, CH3, H, 3,4- 235 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐Γ " 1284639 ,A7 ___B7____ 五、發明說明（W+) ——l·---.----- (請先閱讀背面之注意事項再填寫本頁) di-F-Ph, Η), (Μ-8660, Cl, CH3, Η, 3,4-di.F-Ph, Cl), (M-8661, Cl, CHa, H, 3,4-di-F-Ph, F), (M-8662, Cl, CHs, H, 3,4-di-F.Ph, CFa), (M-8663, Cl, CHa, H, 3,4-di-F-Ph, Br), (M-8664, Cl, CHs, H, 3,4-di.F-Ph, CH3), (M-8665, Cl, CH3, H, 4-COOH-Ph, Η), (M-8666, Cl, CH3, H, 4-COOH-Ph, Cl), (M-8667, Cl, CH3, H, 4· COOH-Ph, F), (M-8668, Cl, CHa, Η, 4.〇ΟΟΙ[.ΡΗ, CFa), (M-8GG9, Cl, Clla, 11, 廉· 經濟部智慧財產局員工消費合作社印製 4-COOH-Ph, Br), (M-8670, Cl, CH3, H，4-COOH-Ph, CH3), (M-8671, Cl, CHa，H， Bn, Η), (M-8672, Cl, CH3, H, Bn, Cl), (M-8673, Cl, CH3, H, Bn, F)，（M-8G74, Cl， CH3, H, Bn, CF3), (M-8675, Cl, CH3, H, Bn, Br), (M.8676, Cl，CIi3, II，Bn，CII3)， (M-8677, Cl, CH3, H, 4-F-Bn, Η), (M-8678, Cl，CH3, H, 4-F-Bn，Cl)，（Μ·8679, Cl， CH3, H, 4-F-Bn, F), (M-8680, Cl, CH3, H, 4-F-Bn, CF3), (M-8681, Cl, CH3, H, 4-F-Bn, Br), (M-8682, Cl, CHa, H, 4-F-Bn, CHa), (M-8683, Cl, CHa, H, 2-Py, H), (M-8684, Cl, CH3, H, 2-Py, Cl), (M-8685, Cl, CH3, H, 2-Py, F)，（M-8686, Cl，CH3, H, 2-Py, CFa), (M-8687, Cl, CHa, H, 2-Py, Br), (M-8688, Cl, CHa, H, 2-Py, CHs), (M-8689, Cl, CH3, H, 3-Py，Η), (M-8690, Cl, CH3, H, 3-Py, Cl), (M-8691，Cl, CH3, H, 3-Py, F), (M-8692, Cl, CH3, H, 3-Py, CF3), (M-8693, Cl, CH3, H, 3-Py，Br), (M-8694, Cl, CH3, H, 3-Py, CH3), (M-8695, Cl, CH3, H, 4-Py, Η), (M-8696, Cl， CH3, H, 4-Py, Cl), (M-8697, Cl, CH3, H, 4-Py, F)，（M-8698, Cl, CH3, H，4-Py， CF3), (M-8699, Cl, CH3, H，4-Py, Br), (M-8700, Cl, CH3, H, 4-Py, CH3)，（M-8701， Cl, CH3, Η, 2·Ί% Η), (M-8702, Cl，CH3, H, 2-Th, Cl), (M-8703, Cl，CH3, H, 2-Th,F),(M-8704,Cl,CH3,H,2-Th，CF3),(M-8705,Cl，CH3，H,2-Th，Br),(M· 8706, Cl, CH3, H, 2-Th, CH3), (M-8707, Cl, CHa, H, 3-Th, Η), (M-8708, Cl, CH3, H, 3-Th, Cl), (M-8709, Cl, CH3, H, 3-Th，F), (M-8710, Cl, CH3, H，3-Th, CF3)， (M-8711, Cl, CH3, H, 3-Th, Br), (M-8712, Cl, CH3, H, 3-Th, CH3)，（M-8713, Cl， CH3, H,吡唑-2-基，Η), (M-8714, Cl, CH3, H,吡唑-2-基，Cl)，（Μ·8715, Cl， CH3, H,吡唑-2-基，F), (M-8716，C1, CH3, H,吡唑-2-基 _ CF3), (M-8717，C1， CH3, H，吡唑-2-棊，Br), (M-8718, Cl, CH3, H,吡唑-2-基，CH3)，（M-8719, 236 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 五、發明說明（W ) C1，CH3，H，吡 Π^·3-^,η), (m-8720, Cl, CH3, Η,吡唑-3-基 C1MM-8721, Cl，CH3, Η，吡唑· 3 基丨 F) (M-8722 C1 ch3, Η,吡唑 3 _ 基，CF3), (Μ-8723, Cl, CHs, Η,吡嘰基! Br), (μ·8724, Cl, CH3, Η,吡唑-3-基，（^13)，（]\1· 8725, Cl，CH3, Η，嘧啶-2-基，Η), (Μ·8726, Cl, CH3, Η,嘧啶-2-基，Cl)， (Μ·8727, Cl, CH3, H，嘧啶基，F), (Μ·8728, Ci, Cih, 11，嘧啶-2-基 |， CF3)，（M-8729, Cl, CH3, Η, 1嘧啶-2-基，Br), (M-8730, Cl, CH3, Η, 嘧啶-2-基，CH3), (M-8731, Cl, CH3, H,嘧啶-4-基，Η), (M-8732, Cl， CH3, H,嘧啶-4·基，Cl), (M-8733, Cl, CH3, H,嘧啶-4-基，F), (M-8734, Cl, CH3, H,嘧啶-4-基 cF3), (Μ·8735, Cl, CH3, H,嘧啶-4-基I，Br), (Μ·8736, Gl，CH3, H,嘧啶-4·基，CH3), (M-8737, Cl, CH3, H,嘧啶-5-基3)，（M-8738, Cl, CH3, H,嘧啶-5-基，Cl), (Μ·8739, Cl, CH3, H, 嘧啶-5-基I ,F), (M-8740, Cl, CH3, H,嘧啶-5-基I CF3)，（M-8741, Cl, CH3, H,嘧啶-5-棊丨，Br), (M-8742, Cl, CH3, H,噃啶-5-基,CH3), (M-8743, Cl, CH3, H, HOOCCH2CH2CH2, Η), (M-8744, Cl, CH3, H, HOOCCH2CH2CH2, Cl), (M-8745, Cl, CH3, H, HOOCCH2CH2CH2, F), (M-8746, Cl, CHa, H, HOOCCH2CH2CH2, CFa), (M-8747, Cl, CHa, H, HOOCCH2CH2CH2, Br), (M-8748, Cl, CHs, H, HOOCCH2CH2CH2, CHa), (M-8749, Cl, CH3, H, HOOCCH2CH2CH2CH2, Η), (M-8750, Cl, CH3, H, HOOCCH2CH2CH2CH2, Cl), (M-8751, Cl, CHa, H, HOOCCH2CH2CH2CH2, F), (M-8752, Cl, CH3, H, HOOCCH2CH2CH2CH2, CF3), (M-8753, Cl, CHa, H, HOOCCH2CH2CH2CH2, Br), (M-8754, Cl, CHa, H, HOOCCH2CH2CH2CH2, GH3), (M-8755, Cl, CH3, H, (Me)2NCOCH2CH2CH2CH2, Η), (M-8756, Cl, CH3, H, (Me)2NCOCH2CH2CH2CH2, Cl), (M-8757, Cl, CH3, H, (Me)2NCOCH2CH2CH2CH2, F), (M-8758, Cl, CH3, H, (Me)2NCOCH2CH2CH2CH2, CF3), (M-8759, Cl, CH3, H, (Me)2NCOCH2CH2CH2CH2, Br), (M-8760, Cl, CHa, H, 237 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） —^----：-------------訂-------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 Δ7 Α7 ___Β7___ 五、發明說明) (Me)2NCOCH2CH2CH2CH2, CH3), (Μ·8761, Cl, CH3, H， (Me)2NCOCH2CH2CH2CH2CH2, H), (M-8762, Cl, CH3, H， (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-8763, Cl, CH3, H, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-8764, Cl, CH3, H, (Me)2NCOCH2CH2CH2〇H2CH2, CFa), (M-87GG, Cl, Oils, 11, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-8766, Cl, CH3, H, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-8767, Cl, CHa, H, MeOCH2, H)，（M-8768, Cl, CH3, H, MeOCH2, Cl), (M-8769, Cl, CH3, H, MeOCH2, F)，（M-8770, Cl， CH3, H, MeOCH2, CF3), (M-8771, Cl, CH3, H, MeOCH2, Br), (M-8772, Cl，CH3, H, MeOCH2, CH3), (M-8773, Cl, CH3, H, EtOCH2, H)，（M-8774, Cl，CH3, H， EtOCH2, Cl), (M-8775, Cl, CH3, H, EtOCH2, F), (M-8776, Cl, CH3, H，EtOCH2, CF3), (M-8777, Cl, CH3, H, EtOCH2, Br), (M-8778, Cl, CH3, H, EtOCH2, CH3), (M-8779, Cl, CH3, H, EtOCH2CH2, Η), (M-8780, Cl, CH3, H，EtOCH2CH2, Cl), (M-8781, Cl, CH3, H, EtOCH2CH2, F), (M-8782, Cl, CH3, H, EtOCH2CH2, CF3)， (M-8783, Cl, CH3, H, EtOCH2CH2, Br), (M-8784, Cl, CH3, H, EtOCH2CH2, CH3)， (M-8785, Cl, CH3, H, MeOCH2CH2〇CH2CH2, Η), (M-8786, Cl, CH3, H， MeOCH2CH2〇CH2CH2, Cl), (M-8787, Cl, CH3, H, MeOCH2CH2〇CH2CH2, F)， (M-8788, Cl, CH3, H, MeOCH2CH2〇CH2CH2, CFa), (M-8789, Cl, CH3, H， MeOCH2CH2〇CH2CH2, Br), (M-8790, Cl, CH3, H, MeOCH2CH2〇CH2CH2, CH3)， (M-8791, Cl, CH3, H, MeOCH2CH2, Η), (M-8792, Cl, CH3, H, MeOCH2CH2, Cl)， (M-8793, Cl, CH3, H, MeOCH2CH2, F), (M-8794, Cl, CHa, H, MeOCH2CH2, CF3), (M-8795, Cl, CH3, H, MeOCH2CH2, Br), (M-8796, Cl, CH3, H，MeOCH2CH2， CH3), (M-8797, Cl, CH3, H, HOCH2, Η), (M-8798, Cl, CH3, H，HOCH2, Cl)， (M-8799, Cl, CH3, H, HOCH2, F), (M-8800, Cl, CH3, H, HOCH2, CF3)，（M-8801， Cl, CHa, H, HOCH2, Br)，（M-8802, Cl, CH3, H, HOCH2, CH3)，（M-8803, Cl，CH3, H, HOCH2CH2, Η), (M-8804, Cl, CHs, H, HOCH2CH2, Cl), (M-8805, Cl, CH3, H, 238 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） —：—.-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 ___B7___ 五纖福 ,(Μ^806, Cl, CHa, H, HOCH2CH2, CFa), (M-8807, Cl, CHa, H, HOCH2CH2, Br), (M-8808, Cl, CH3, H, HOCH2CH2, CH3), (M-8809, Cl，CH3, H， HOCH2CH2CH2, Η), (M-8810, Cl, CHa, H, HOCH2CH2CH2, Cl), (M-8811, Cl, CHa, H, HOCH2CH2CH2, F), (M-8812, Cl, CH3, H, HOCH2CH2CH2, CFa), (M-8813, Cl, CHa, H, HOCH2CII2CH2, I3r), (M-88H, Cl, Clla, II, IlOCIbClhCna, CH3), (M-8815, Cl, CH3, H, HOCH2CH2CH2CH2, Η), (M-8816, Cl, CH3, H, HOCH2CH2CH2CH2, Cl), (M-8817, Cl, CHa, H, HOCH2CH2CH2CH2, F), (M-8818, Cl, CHs, H, HOCH2CH2CH2CH2, CFa), (M-8819, Cl, CHa, H, HOCH2CH2CH2CH2, Br), (M-8820, Cl, CH3, H, HOCH2CH2CH2CH2, CHa), (M-8821, Cl, CH3, H, HOCH2CH2CH2CH2CH2, Η), (M-8822, Cl, CH3, H, HOCH2CH2CH2CH2CH2, Cl), (M-8823, Cl, CHa, H, HOCH2CH2CH2CH2CH2, F), (M-8824, Cl, CHa, H, HOCH2CH2CH2CH2CH2, CFa), (M-8825, Cl, CHa, H, HOCH2CH2CH2CH2CH2, Br), (M-8826, Cl, CHa, H, HOCH2CH2CH2CH2CII2, CH3), (M-8827, Cl, CHs, H, HOCH2CH2OCH2CH2, Η), (M-8828, Cl, CH3, H, HOCH2CH2OCH2CH2, Cl), (M-8829, Cl, CHs, H, HOCH2CH2OCH2CH2, F), (M-8830, Cl, CHa, H, HOCH2CH2OCH2CH2, CFa), (M-8831, Cl, CHa, H, HOCH2CH2OCH2CH2, Br), (M-8832, Cl, CHa, H, HOCH2CH2OCH2CH2, CHa), (M-8833, Cl, CHs, H, (Me)2N, Η), (M-8834, Cl, CHa, H, (Me)2N, Cl), (M-8835, Cl, CH3, H, (Me)2N, F), (M-8836, Cl, CH3, H, (Me)2N, CFs), (M-8837, Cl, CH3, H， (Me)2N, Br), (M-8838, Cl, CH3, H，（Me)2N，CH3), (M-8839, Cl, CH3, H, 哌啶· 4 基甲基 i, Ή), (M-8840, Cl, CH3, H,哌啶-4 -基甲基，Cl)， (M-8841, Cl, CH3, H,哌啶·4_基甲基，F), (M-8842, Cl，CII3, H， 哌啶-4 -基甲基 L CFO, (M·8843, Cl, CH3, H,哌啶 4 ·基甲基，Br), (M-8844, Cl，CH3, H，哌啶-4-基甲基，CH3), (M-8845, Cl, CH3, H， 環己基甲基，Η), (M-8846, Cl, CH3, H,環己基甲基，Cl), (M-8847, Cl， CH3, H,環己基甲基，F), (M-8848, Cl, CH3, H，環己基甲基，CF3)， 239 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --l· — — —- — — — I— - I I I I I--^ ·11111111 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 ：. ___JB7___ 五、發明說明卜W) (M-8849, Cl, CH3, Η,環己基甲基，Br), (M-8850, Cl, CH3, Η, 環己基甲基，CH3), (M-8851, Cl, CH3, F，Η, Η), (M-8852, Cl，CH3, F, H, Cl)， (M-8853, MeO, CH3, F, H, F), (M-8854, Cl, CH3, F, H, CF3), (M-8855, Cl, CH3, F, H, Br), (Μ·8856, Cl, CH3, F, H, CH3), (M-8857, Cl, CH3, F, F, Η), (M-8858, Cl, CH3, F, F, Cl), (M-8859, Cl, CHs, F, F, F), (M-8800, Cl, Clla, F, ΙΛ OKa), (M-881M, Cl, CH3, F, F, Br), (M-8862, Cl, CHa, F, F, CH3), (M-8863, Cl, CH3, F, Cl, H), (M-8864, Cl, CH3, F, Cl, Cl), (M-8865, Cl, CH3, F, Cl, F), (M-8866, Cl, CH3, F，Cl， CF3), (M-8867, Cl, CH3, F, Cl, Br), (M-8868, Cl, CH3, F, Cl, CH3)，（M-8869, Cl， CH3, F, CH3, Η), (M-8870, Cl, CH3, F，CH3, Cl), (M-8871, Cl, CH3, F, CH3, F), (M-8872, Cl, CHa, F, CHs, CFa), (M-8873, Cl, CHa, F, CHa, Br), (M-8874, Cl, CH3, F, CH3, CH3), (M-8875, Cl, CH3, F, Et, Η), (M-8876, Cl，CH3, F, Et, Cl), (M-8877, Cl, CH3, F, Et, F), (M-8878, Cl, CH3, F, Et, CF3), (Μ·8879, Cl, CH3, F, Et, Br), (M-8880, Cl, CH3, F, Et, CH3), (M-8881, Cl, CH3, F, n-Pr, Η), (M-8882, Cl, CH3, F, n-Pr, Cl), (M-8883, Cl, CH3, F, n-Pr, F), (M-8884, Cl, CHa, F, n-Pr, CF3), (M-8885, Cl, CH3, F, n-Pr, Br), (M-8886, Cl, CH3, F, n-Pr, CH3), (M-8887, Cl, CH3, F, c-Pr, Η), (M-8888, Cl, CH3, F, c-Pr, Cl), (Μ·8889, Cl, CH3, F, c-Pr, F)， (M-8890, Cl, CH3, F, c-Pr, CF3), (M-8891, Cl, CH3, F, c-Pr, Br), (M-8892, Cl， CH3, F, c-Pr, CH3), (M-8893, Cl, CH3, F, i-Pr, Η), (M-8894, Cl, CH3, F, i-Pr，Cl)， (M-8895, Cl, CHs, F, i-Pr, F), (M-8896, Cl, CHa, F, i-Pr, CFa), (M-8897, Cl, CHa, F, i-Pr, Br), (M-8898, Cl, CH3, F, i-Pr, CHs), (M-8899, Cl, CHs, F, n-Bu, H), (M-8900, Cl, CH3, F, n-fiu, Cl), (M-8901, Cl, CH3, F, n-Bu, F), (M-8902, Cl, CH3, F, n-Bu, CF3), (M-8903, Cl, CH3, F, n-But Br), (M-8904, Cl, CHa, F, n-Bu, CHa), (M-8905, Cl, CH3, F, i-Bu, Η), (M-8906, Cl, CH3, F, i-Bu, Cl), (M-8907, Cl，CH3, F，i-Bu, F), (M-8908, Cl, CH3, F, i-Bu, CF3), (M-8909, Cl, CH3, F, i-Bu，Br)， (M-8910, Cl, CH3, F, i-Bu, CH3), (M-8911, Cl, CH3, F，sec-Bu, H)，（M-8912, Cl, CH3, F, sec-Bu, Cl), (M-8913, Cl, CH3, F, eec-Bu, F), (M-8914, Cl, CH3, F, sec- 240 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） —：----：-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、發明說明（叫）
Bu, CFa), (M-8915, Cl, CHa, F, sec-Bu, Br), (M-8916, Cl, CHa, F, sec-Bu, CH3), (M-8917, Cl, CHa, F, n-Pen, Η), (M-8918, Cl, CHa, F, n-Pen, Cl), (M-8919, Cl, CHa, F, n-Pen, F), (M-8920, Cl, CHa, F, n-Pen, CFa), (M-8921, Cl, CHa, F, n-Pen, Br), (M-8922, Cl, CHa, F, n-Pen, CH3), (M-8923, Cl, CHa, F, c-Pen, Η), (M-8924, Cl, CHa, F, c-Pen, Cl), (M-8925, Cl, CH3, F, c-Pen, F), (M-8926, Cl, Oils, F, c-Pen, CF3), (M-8927, Cl, CH3, F, c-Pen, Br), (M-8928, Cl, CH3, F, c-Pen· CH3), (M-8929, Cl, CH3, F, n-Hex, Η), (M-8930, Cl, CH3, F, n-Hex, Cl), (Μ·8931, Cl, CHa, F, n-Hex, F), (M-8932, Cl, CHs, F, n-Hex, CFa), (M-8933, Cl, CHa, F, n-Hex, Br), (M-8934, Cl, CH3, F, n-Hex, CH3), (Μ·8935, Cl, CH3, F, c-Hex, H)， (M-8936, Cl, CHa, F, c-Hex, Cl), (M-8937, Cl, CHs, F, c-Hex, F), (M-8938, Cl, CH3,F,c-Hex,CF3),(M-8939,Cl,CH3,F,c-Hex,Br),(M-8940,Cl,CH3,F,c-Hex，CH3), (M-8941, Cl, CH3, F, OH, Η), (M-8942, Cl, CH3, F, OH, Cl), (M-8943, Cl, CH3, F, OH, F), (M-8944, Cl, CH3, F, OH, CF3), (M-8945, Cl, CH3, F, OH, Br)， (M-8946, Cl, CHs, F, OH, CHs), (M-8947, Cl, CHa, F, EtO, Η), (M-8948, Cl, CHs, F, EtO, Cl), (M-8949, Cl, CHa, F, EtO, F), (M-8950, Cl, CHa, F, EtO, CF3), (M-8951, Cl, CH3, F, EtO, Br), (M-8952, Cl, CH3, F, EtO, CH3), (M-8953, Cl, CH3, F, n-PrO, Η), (M-8954, Cl, CH3, F, n-PrO, Cl), (M-8955, Cl, CH3, F, n-PrO, F)， (M-8956, Cl, CHs, F, n-PrO, CF3), (M-8957, Cl, CHa, F, n-PrO, Br), (M-8958, Cl, CH3, F, n-PrO, CHs), (M-8959, Cl，CH3, F, PhO, Η), (M-8960, Cl, CH3, F, PhO, Cl), (M-8961, Cl, CH3, F, PhO, F), (M-8962, Cl, CH3, F, PhO, CF3)，（M-8963, Cl， CH3, F, PhO, Br), (M-8964, Cl, CH3, F, PhO, CHa), (M-8965, Cl, CHa, F, BnO, H), (M-8966, Cl, CHa, F, BnO, Cl), (M-8967, Cl, CHa, F, BnO, F), (M-8968, Cl, CHa, F, BnO, CF3), (M-8969, Cl, CH3, F, BnO, Br), (M-8970, Cl, CH3, F, BnO, CH3)， (M-8971, Cl, CH3, F, PhCH2CH2〇, Η), (M-8972, Cl, CH3, F, PhCH2CH2〇, Cl)， (M-8973, Cl, CH3, F, PhCH2CH2〇, F), (M-8974, Cl, CH3, F, PhCH2CH20, CF3)， (M-8975, Cl, CH3, F, PhCH2CH2〇, Br), (M4976, Cl, CH3, F, PhCH2CH2〇, CH3)， 241 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） —l—--------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 _B7____ 五、發明說明 (Μ·8977, Cl, CH3, F, CF3〇, Η), (M-8978, Cl, CH3, F, CF3〇, Cl), (M-8979, Cl， CH3, F, CF3〇, F), (M-8980, Cl, CH3, F, CF3〇, CF3), (Μ·8981, Cl, CH3, F，CF3〇, Br), (M-8982, Cl, CH3, F, CF3〇, CH3), (M-8983, Cl, CHs, F, Ph, Η), (M-8984, Cl， CH3, F, Ph, Cl), (M-8985, Cl, CH3, F, Ph，F), (M-8986, Cl, CH3, F，Ph, CF3)， (M-8987, Cl, CHa, F, Ph, Br), (M-8988, Cl, CHa, F, Ph, CHa), (M-8989, Cl, CHa, F, 4-F-Ph, Η), (M-8990, Cl, CH3, F, 4-F-Ph, Cl), (M-8991, Cl, CH3, F, 4-F-Ph，F)， (M-8992, Cl, CH3, F, 4-F-Ph, CF3), (M-8993, Cl, CH3, F, 4-F-Ph, Br), (M-8994, Cl, CHa, F, 4-F-Ph, CHs), (M-8995, Cl, CHa, F, 4-CF3-Ph, Η), (M-8996, Cl, CHs, F，4-CF3-Ph,Cl),(M-8997,Cl,CH3,F,4-CF3-Ph,F),(M-8998,Cl，CH3，F，4-CF3.Ph, CFa), (M-8999, Cl, CH3, F, 4-CF3-Ph, Br), (M-9000, Cl, CHa, F, 4-CF3-Ph, CHa), (M-9001, Cl, CHa, F, 4-(Me)2N-Ph, Η), (M-9002, Cl, CHa, F, 4-(Me)2N-Ph, Cl), (M-9003, Cl, CH3, F, 4-(Me)2N-Ph, F), (M-9004, Cl，CH3, F，4-(Me)2N-Ph, CFs), (M-9005, Cl, CHs, F, 4.(Me)2N-Ph, Br), (M-9006, Cl, CHa, F, 4-(Me)2N-Ph, CH3), (M-9007, Cl, CH3, F, 4-OH-Ph, Η), (M-9008, Cl, CH3, F, 4-OH-Ph, Cl), (M-9009, Cl, CH3, F, 4-OH-Ph, F), (M-9010, Cl, CH3, F, 4-OH-Ph， CFa), (M-9011, Cl, CH3, F, 4-OH-Ph, Br), (M-9012, Cl, CHa, F, 4-OH-Ph, CHs), (M-9013, Cl, CH3, F, 3,4-di-F-Ph, Η), (M-9014, Cl, CH3, F, 3,4-di-F-Ph, Cl)， (M-9015, Cl, CH3, F, 3,4-di-F-Ph, F), (M-9016, Cl, CH3, F, 3,4-di-F-Ph, CF3)， (M-9017, Cl, CHa, F, 3,4-di-F-Ph, Br), (M-9018, Cl, CHa, F, 3,4-di-F-Ph, CHa), (M-9019, Cl, CH3, F, 4-COOH-Ph, H)，（M-9020, Cl, CH3, F, 4-COOH-Ph, Cl), (M-9021, Cl, CHs, F, 4-COOH-Ph, F), (M-9022, Cl, CHa, F, 4-COOH-Ph, CFa), (M-9023, Cl, CHa, F, 4-COOH-Ph, Br), (M-9024, Cl, CHs, F, 4-COOH-Ph, CHa), (M-9025, Cl, CHa, F, Bn, Η), (M-9026, Cl, CHa, F, Bn, Cl), (M-9027, Cl, CHa, F, Bn, F), (M-9028, Cl, CH3, F, Bn, CF3), (M-9029, Cl, CH3, F, Bn, Br), (M-9030, Cl， CHa, F, Bn, CHs), (M-9031, Cl, CHa, F, 4-F-Bn, Η), (M-9032, Cl, CHa, F, 4-F-Bn, Cl), (M-9033, Cl, CHa, F, 4-F-Bn, F), (M-9034, Cl, CH3, F, 4-F-Bn, CF3), 242 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -! l·— — —.----- (請先閱讀背面之注意事項再填寫本頁) 訂--- 經濟部智慧財產局員工消費合作社印製 1284639 A7 _B7___ 五、發明說明（>^ ) (M-9035, Cl, CH3, F, 4-F-Bn, Br), (M-9036, Cl, CH3, F, 4-F-Bn, CH3), (M-9037, Cl, CHa, F, 2-Py, Η), (M-9038, Cl, CHa, F, 2-Py, Cl), (M-9039, Cl, CHs, F, 2-Py, F), (M-9040, Cl, CH3, F, 2-Py，CF3), (M-9041, Cl, CH3, F, 2-Py，Br), (M-9042, Cl， CH3, F, 2-Py, CH3), (M-9043, Cl, CH3, F, 3-Py, Η), (M-9044, Cl, CH3, F, 3-Py， Cl), (M-9045, Cl, CHs, F, 3-Py, F), (M-9046, Cl, Clla, F, 8-Py, CFa), (M-9047, Cl, CHa, F, 3-Py, Br), (M-9048, Cl, CHa, F, 3-Py, CHa), (M-9049, Cl, CHa, F, 4-Py, H)，（M-9050, Cl, CH3, F, 4-Py, Cl), (M-9051, Cl, CH3, F, 4-Py, F), (M-9052, Cl, CH3, F, 4-Py, CFa), (M-9053, Cl, CH3, F, 4-Py, Br), (M-9054, Cl，CH3, F，4-Py， CH3), (M-9055, Cl, CH3, F, 2-Th, Η), (M-9056, Cl，CH3, F, 2-Th，Cl), (M-9057, Cl， CH3, F, 2-Thi, F), (M-9058, Cl, CH3, F，2-Th，CF3), (M-9059, Cl, CH3, F, 2-Th, Br), (M-9060, Cl, CH3, F, 2-Th, CH3), (M-9061, Cl, CH3, F, 3-Th, Η), (M-9062, Cl， CH3, F, 3-Th, Cl), (M-9063, Cl，CH3, F，3-Th，F), (M-9064, Cl, CH3, F，3-Th, CF3)， (M-9065, Cl, CHa, F, 3-Th, Br), (M-9066, Cl, CHa, F, 3-Th, CH3), (M-9067, Cl, CH3, F,吡唑-2-基 ί Η), (M-9068, Cl, CH3, F,吡唑-2-基，Cl), (M-9069, Cl， CH3, F,吡唑-2_基，F), (M-9070, Cl，CHa，F,吡哩-2·基，CF3)，（M-9071，C1, CH3, F,吡唑-2·基，Br), (M-9072, Cl, CH3, F,吡唑-2-基，CH3), (M-9073, C1,CH3,F,吡唑-3-基，η), (M-9074, Cl, CH3, F,吡唑-3-基，Cl), (M-9075, Cl, CH3, F,吡唑-3 -基，F), (M-9076, Cl, CH3, F,吡唑-3 -基，CF3)，（M-9077, Cl, CH3, F,吡唑-3-基，Br), (M-9078, Cl, CH3, F,吡唑-3-基:，CHs), (M-9079, Cl, CH3, F,嘧啶-2-基，Η), (M-9080, Cl, CH3, F，嘧 n定-2-基，Cl)， (M-9081, Cl, CH3, F,嘧啶-2-基，F), (M-9082, Cl, CH3, F,嘧啶-2-基， CF3), (M-9083, Cl, CHs, F,嘧 n定-2-基，Br), (M-9084, Cl, CH3, F， 嘧啶-2-基，CH3), (M-9085, Cl, CH3, F,嘧啶-4-基，H)，（M-9086, Cl， CH3, F,嘧啶-4-基，Cl), (Μ·9087, Cl, CH3, F,嘧啶-4-基，F), (M-9088, Cl, CH3, F,嘧啶-4-基，CF3)，（M-9089, Cl, CH3, F,嘧啶-4-基，Br)， (M-9090, Cl, CH3, F,嘧啶-4-基,CH3), (M-9091, Cl, CH3, F，嘧 D定-5- 243 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ——l·---.----- (請先閱讀背面之注意事項再填寫本頁) tr---------MW. 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 ____
五、發明說明（MM _，H), (M-9092, Cl, CH3, F,嘧啶-5-基,〇1>, (M-9093, Cl, CH3, F， (請先閱讀背面之注意事項再填寫本頁) 嘧啶-5 -基，F), (M-9094, Cl，CH3, F,嘧啶-5 -基，CF3), (M-9095, Cl, CH3, F,嚼啶-5 -基 I , Br), (M-9096, Cl, CH3, F,嘧啶-5 基，CH3), (M-9097, Cl, CHa, F, HOOCCH2CH2CH2, Η), (M-9098, Cl, CHa, F, HOOCCH2CH2CH2, Cl), (M-9099, Cl, CH3, F, HOOCCIIaCIIaCHa, F), (M-i)lOO, Cl, (ilia, K, HOOCCH2CH2CH2, CFa), (M-9101, Cl, CHa, F, HOOCCH2CH2CH2, Br), (M-9102, Cl, CHa, F, HOOCCH2CH2CH2, CHa), (M-9103, Cl, CHa, F, HOOCCH2CH2CH2CH2, Η), (M-9104, Cl, CHa, F, HOOCCH2CH2CH2CH2, Cl), (M-9105, Cl, CHs, F, HOOCCH2CH2CH2CH2, F), (M-9106, Cl, CHa, F, HOOCCH2CH2CH2CH2, CF3), (M-9107, Cl, CHa, F, HOOCCH2CH2CH2CH2, Br), (M-9108, Cl, CHa, F, HOOCCH2CH2CH2CH2, CHa), (M-9109, Cl, CHa, F, (Me)2NCOCH2CH2CH2CH2, Η), (M-9110, Cl, CH3, F, (Me)2NCOCH2CH2CH2CH2, Cl), (M-9111, Cl, CH3, F, 經濟部智慧財產局員工消費合作社印製 (Me)2NCOCH2CH2CH2CH2, F), (M-9112, Cl, CH3, F, (Me)2NCOCH2CH2CH2CH2, CF3), (M-9113, Cl, CH3, F, (Me)2NCOCH2CH2CH2CH2, Br), (M-9114, Cl, CH3, F， (Me)2NCOCH2CH2CH2CH2, CH3)，（M-9115, Cl, CH3, F, (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-9116, Cl, CH3, F， (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-9117, Cl, CHs, F, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-9118, Cl, CHs, F, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-9119, Cl, CH3, F, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-9120, Cl, CHs, F, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-9121, Cl, CH3, F, MeOCH2, H)，（M-9122, Cl, CH3, F, MeOCH2, Cl), (M-9123, Cl，CH3, F, MeOCH2, F), (M-9124, Cl， CH3, F, MeOCH2, CF3), (M-9125, Cl, CH3, F, MeOCH2, Br), (M-9126, Cl, CH3, F， MeOCH2, CH3), (Μ·9127, Cl, CH3, F, EtOCH2, Η), (M.9128, Cl, CH3, F, EtOCH2, Cl), (M-9129, Cl, CH3, F, EtOCH2, F), (M-9130, Cl, CH3, F，EtOCH2, CF3), 244 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） A7 1284639 _____B7___ 五、發明說明卜W) (M-9131, Cl, CHs, F, EtOCHa, Br), (M-9132, Cl, CHa, F, EtOCH2, CHa), (M-9133, Cl, CH3, F, EtOCH2CH2, Η), (M-9134, Cl, CH3, F, EtOCH2CH2, Cl), (M-9135, Cl, CH3, F, EtOCH2CH2, F), (M-9136, Cl, CH3, F, EtOCH2CH2, CF3), (M-9137, Cl, CH3, F, EtOCH2CH2, Br), (M-9138, Cl, CH3, F, EtOCH2CH2, CH3), (M-9139, Cl, CHa, F, MeOCH2CH2〇CH2CH2, Η), (M-9140, Cl, CHa, F, MoOCli2CU2UCll2〇H2> Cl), (M-9141, Cl, CH3, F, MeOCH2CH2〇CH2CH2, F), (M-9142, Cl, CH3, F, MeOCH2CH2〇CH2CH2, CF3), (M-9143, Cl, CH3, F, MeOCH2CH2〇CH2CH2, Br), (M-9144, Cl, CH3, F, MeOCH2CH2〇CH2CH2, CH3), (M-9145, Cl, CH3, F, MeOCH2CH2, Η), (M-9146, Cl, CH3, F, MeOCH2CH2, Cl), (M-9147, Cl, CHs，F, MeOCH2CH2, F), (M-9148, Cl, CH3, F, MeOCH2CH2, CF3), (M-9149, Cl, CH3, F, MeOCH2CH2, Br), (M-9150, Cl, CH3, F, MeOCH2CH2, CH3), (M-9151, Cl, CH3, F, HOCH2, Η), (M-9152, Cl, CH3, F, HOCH2, Cl), (M-9153, Cl, CHa, F, HOCH2, F), (M-9154, Cl, CH3, F, HOCH2, CFa), (M-9155, Cl, CHa, F, HOCH2, Br), (M-9156, Cl, CHs, F, HOCH2, CH3), (M-9157, Cl, CHa, F, HOCH2CH2, Η), (M-9158, Cl, CHa, F, HOCH2CH2, Cl), (M-9159, Cl, CH3, F, HOCH2CH2, F), (M-9160, Cl, CH3, F, HOCH2CH2, CFs), (M-9161, Cl, CHa, F, HOCH2CH2, Br), (M-9162, Cl, CH3, F, HOCH2CH2, CH3), (M-9163, Cl, CHa, F, HOCH2CH2CH2, Η), (M-9164, Cl, CII3, F, HOCH2CH2CH2, Cl), (M-9165, Cl, CH3, F, HOCH2CH2CH2, F), (M-9166, Cl, CH3, F, HOCH2CH2CH2, CFs), (M-9167, Cl, CHa, F, HOCH2CH2CH2, Br), (M-9168, Cl, CHs, F, HOCH2CH2CH2, CH3), (M-9169, Cl, CH3, F, HOCH2CH2CH2CH2, Η), (M-9170, Cl, CHa, F, HOCH2CH2CH2CH2, Cl), (M-9171, Cl, CHa, F, HOCH2CH2CH2CH2, F), (M-9172, Cl, CHa, F, HOCH2CII2CH2CH2, CFa), (M-9173, Cl, CHa, F, HOCH2CH2CH2CH2, Br), (M-9174, Cl, CHa, F, HOCH2CH2CH2CH2, CH3), (M-9175, Cl, CHa, F, HOCH2CH2CH2CH2CH2, H), (M-9176, Cl, CHa, F, HOCH2CH2CH2CH2CH2, Cl), (M-9177, Cl, CHa, F, HOCH2CH2CH2CH2CH2, F), (M-9178, Cl, CHa, F, HOCH2CH2CH2CH2CH2, CF3), 245 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ： -------------------訂·------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 A7 1284639 ________B7___ 五、發明說明（0斗） (請先閱讀背面之注意事項再填寫本頁) (M-9179, Cl, CHa, F, HOCH2CH2CH2CH2CH2, Br), (M-9180, Cl, CHs, F, HOCH2CH2CH2CH2CH2, CH3), (M-9181, Cl, CHa, F, HOCH2CH2OCH2CH2, H), (M-9182, Cl, CHa, F, HOCH2CH2OCH2CH2, Cl), (M-9183, Cl, CH3, F, HOCH2CH2OCH2CH2, F), (M-9184, Cl, CHa, F, HOCH2CH2OCH2CH2, CF3), (M-9185, Cl, CHs, F, HOCH2CH2OCH2CH2, Br), (Μ-ΟΙΘΟ, Cl, Clla, K, HOCH2CH2OCH2CH2, CH3), (M-9187, Cl, CH3, F, (Me)2N, Η), (M-9188, Cl，CH3, F, (Me)2N, Cl), (M-9189, Cl, CHa, F, (Me)2N, F), (M-9190, Cl, CH3, F, (Me)2N, CF3), (M-9191, Cl, CH3, F, (Me)2N, Br), (M-9192, Cl, CH3, F，（Me)2N, CH3)， (M-9193, Cl, CHa, F,哌啶-4-基甲基，H)，（M-9194, Cl，CH3, F， 哌啶-4 -基甲基，Cl), (M-9195, Cl, CH3, F,哌啶 _ 4 -基甲基，F), (M-9196, Cl, CH3, F,哌啶-4·基甲基丨，CF3), (M-9197, Cl, CH3, F, 哌啶-4 基甲基，Br), (M-9198, Cl, CH3, F,哌啶-4 -基甲基，CH3), (M-9199, Cl, CH3, F,環己基甲基 1, Η), (M-9200, Cl, CH3, F, 經濟部智慧財產局員工消費合作社印製 環己基甲基，Cl), (M-9201, Cl, CH3, F,環己基甲基 F), (M-92〇2, Cl, CH3, F,環己基甲基，CF3), (M-9203, Cl, CH3, F,環己基甲基，Br), (M-9204, Cl, CH3, F,環己基甲基，CH3), (Μ·9205, Cl，CH3, Cl, Η, H)， (M-9206, Cl, CHs, Cl, H, Cl), (M-9207, Cl, CHa, Cl, H, F), (M-9208, Cl, CH3, Cl, H, CF3), (M-9209, Cl, CH3, Cl, H, Br), (M-9210, Cl, CH3, Cl, H, CH3)，（M-9211, Cl, CH3, Cl, F, Η), (M-9212, Cl, CH3, Cl, F, Cl), (M-9213, Cl，CH3, Cl，F, F)， (M-9214, Cl, CH3, Cl, F, CF3), (M-9215, Cl, CH3, Cl, F, Br), (M-9216, Cl，CH3, Cl, F, CH3)，（M-9217, Cl, CH3, Cl, Cl, Η), (M-9218, Cl, CH3, Cl, Cl, Cl), (Μ·9219, Cl， CH3, Cl, Cl, F), (M-9220, Cl, CH3, Cl, Cl, CF3), (Μ·9221, Cl, CH3, Cl, Cl，Br)， (M-9222, Cl, CHs, Cl, Cl, CH3), (M-9223, Cl, CHa, Cl, CHa, Η), (M-9224, Cl, CHa, Cl, CH3, Cl), (M-9225, Cl, CH3, Cl, CH3, F), (M-9226, Cl, CH3, Cl, CH3, CF3), (M-9227, Cl, CHs, Cl, CH3, Br), (M-9228, Cl, CHs, Cl, CHs, CHs), (M-9229, Cl CHs, Cl, Et, Η), (M-9230, Cl, CH3, Cl, Et, Cl), (M-9231, Cl, CHa, Cl, Et, F), 246 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） A7 1284639 _ B7_ 五、發明說明（^) (M-9232, Cl, CH3, Cl, Et, CFs), (M-9233, Cl, CHa, Cl, Et, Br), (M-9234, Cl, CHa, Cl, Et, CH3), (M-9235, Cl, CH3, Cl, n-Pr, Η), (M-9236, Cl, CH3, Cl, n-Pr, Cl>, (M-9237, Cl, CHa, Cl, n-Pr, F), (M-9238, Cl, CHa, Cl, n-Pr, CFa), (M-9239, Cl, CH3, Cl, n-Pr, Br), (M-9240, Cl, CH3, Cl, n-Pr, CH3)，（M-9241, Cl, CH3, Cl，c-Pr, Η), (M-9242, Cl, CHs, Cl, c-Pr, Cl), (M-9243, Cl, (JHa, Cl, c-Pr, F), (M-U244, Cl, CH3, Cl, c-Pr, CF3), (M-9245, Cl, CH3, Cl, c-Pr, Br), (Μ·9246, Cl, CH3, Cl, c-Pr, CH3), (M-9247, Cl, CH3, Cl, i-Pr, Η), (M-9248, Cl, CH3, Cl, i-Pr，Cl), (M-9249, Cl, CH3, Cl, i-Pr, F), (M-9250, Cl, CH3, Cl, i-Pr, CF3), (M-9251, Cl, CHs, Cl, i-Pr, Br), (M-9252, Cl, CH3, Cl, i-Pr, CH3), (M-9253, Cl, CH3, Cl，η·Βιι，H)， (M-9254, Cl, CHa, Cl, n-Bu, Cl), (M-9255, Cl, CH3, Cl, n-Bu, F), (M-9256, Cl, CHa, Cl, n-Bu, CFa), (M-9257, Cl, CHa, Cl, n-Bu, Br), (M-9258, Cl, CH3, Cl, n-Bu, CH3), (Μ·9259, Cl, CH3, Cl, i-Bu, Η), (M-9260, Cl, CH3, Cl, i-Bu, Cl), (M-9261, Cl, CHs, Cl, i-Bu, F), (M-9262, Cl, CHa, Cl, i-Bu, CFs), (M-9263, Cl, CHa, Cl, i-Bu, Br), (M-9264, Cl, CHa, Cl, i-Bu, CHa), (M-9265, Cl, CH3, Cl, sec-Bu, H), (M-9266, Cl, CHa, Cl, sec-Bu, Cl), (M-9267, Cl, CHa, Cl, sec-Bu, F), (M-9268, Cl, CH3, Cl, sec-Bu, CF3), (M-9269, Cl, CH3, Cl, sec-Bu, Br), (Μ·9270, Cl，CH3, Cl, sec-Bu, CH3)，（M-9271，Cl, CH3, Cl, n-Pen, Η), (M-9272, Cl, CH3, Cl, n-Pen, Cl), (M-9273, Cl, CHa, Cl, n-Pen, F), (M-9274, Cl, CHa, Cl, n-Pen, CF3), (M-9275, Cl, CH3, Cl, n-Pen, Br), (M.9276, Cl, CH3, Cl, n-Pen, CH3), (M-9277, Cl，CH3, Cl, c-Pen, H>, (M-9278, Cl, CH3, Cl, c-Pen, Cl), (M-9279, Cl, CH3, Cl, c-Pen，F)， (M-9280, Cl, CHs, Cl, c-Pen, CF3), (M-9281, Cl, CHa, Cl, c-Pen, Br), (M-9282, Cl, CHa, Cl, c-Pen, CHs), (M-9283, Cl, CH3, Cl, n-Hex, Η), (M-9284, Cl, CHa, Cl, n-Hex, Cl), (M-9285, Cl, CH3, Cl, n-Hex, F), (M-9286, Cl, CH3, Cl, n-Hex, CFs), (M-9287, Cl, CH3, Cl, n-Hex, Br), (M-9288, Cl, CH3, Cl，n-Hex, CH3), (M-9289, Cl, CH3, Cl, c-Hex, Η), (M-9290, Cl, CH3, Cl, c-Hex, Cl), (M-9291, Cl, CHs, Cl, c-Hex, F), (M-9292, Cl, CHa, Cl, c-Hex, CF3), (M-9293, Cl, CHa, Cl, c-Hex, Br), 247 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ------.-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 A7 B7 1284639 五、發明說明（>#) (請先閱讀背面之注音？事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 (M-9294, Cl, CH3, Cl, c-Hex, CH3), (M-9295, Cl, CH3, Cl, OH, Η), (M-9296, Cl, CHs, Cl, OH, Cl), (M-9297, Cl, CHs, Cl, OH, F), (M-9298, Cl, CHa, Cl, OH, CFs), (M-9299, Cl, CHa, Cl, OH, Br), (M-9300, Cl, CHa, Cl, OH, CHa), (M-9301, Cl, CH3, Cl, EtO, Η), (M-9302, Cl, CHa, Cl, EtO, Cl), (M-9303, Cl, CHa, Cl, EtO, F), (M-9304, Cl, CHa, Cl, EtO, CFa), (M-9305, Cl, Clla, Cl, EtO, Ur), (M-930G, Cl, CHa, Cl, EtO, CHs), (M-9307, Cl, CH3, Cl, n-PrO, Η), (M-9308, Cl, CH3, Cl, n-PrO, Cl), (M-9309, Cl, CHa, Cl, n-PrO, F), (M-9310, Cl, CHa, Cl, n-PrO, CFa), (M-9311, Cl, CHa, Cl, n-PrO, Br), (M-9312, Cl, CHa, Cl, n-PrO, CHa), (M-9313, Cl, CHs, Cl, PhO, Η), (M-9314, Cl, CH3, Cl, PhO, Cl), (M-9315, Cl, CHa, Cl, PhO, F), (M-9316, Cl, CHa, Cl, PhO, CFa), (M-9317, Cl, CH3, Cl, PhO, Br), (M-9318, Cl, CHa, Cl, PhO, CH3), (M-9319, Cl, CHa, Cl, BnO, Η), (M-9320, Cl, CH3, Cl, BnO, Cl), (Μ·9321, Cl, CH3, Cl, BnO, F), (M-9322, Cl, CH3, Cl, BnO, CF3), (M-9323, Cl, CH3, Cl, BnO, Br), (M-9324, Cl, CHa, Cl, BnO, CHs), (M-9325, Cl, CH3, Cl, PhCH2CH2〇, Η), (M-9326, Cl, CH3, Cl, PI1CH2CH2O, Cl), (M-9327, Cl， CH3, Cl, PhCH2CH2〇, F), (M-9328, Cl, CH3, Cl, PhCH2CH2〇, CF3), (M-9329, Cl， CH3, Cl, PhCH2CH2〇, Br), (M-9330, Cl, CH3, Cl, PI1CH2CH2O, CH3), (M-9331， Cl, CHa, Cl, CF3〇, Η), (M-9332, Cl, CHs, Cl, CFsO, Cl), (M-9333, Cl, CHa, Cl, CF30, F), (M-9334, Cl, CH3, Cl, CF3〇, CF3), (M-9335, Cl, CH3, Cl, CF3〇, Br)， (M-9336, Cl, CH3, Cl, CF3〇, CHs), (M-9337, Cl, CHa, Cl, Ph, Η), (M-9338, Cl, CH3, Cl, Ph, Cl), (M-9339, Cl, CH3, Cl, Ph, F), (M-9340, Cl, CH3, Cl, Ph，CF3), (M-9341, Cl, CH3, Cl, Ρίι, Br), (M-9342, Cl, CH3, Cl, Ph, CH3), (M-9343, Cl, CH3, Cl, 4-F-Ph, Η), (M-9344, Cl, CH3, Cl，4-F-Ph, Cl), (M-9345, Cl, CH3, Cl，4-F-Ph， F), (M-9346, Cl, CH3, Cl, 4-F-Ph, CF3), (M-9347, Cl, CHa, Cl, 4-F-Ph, Br), (M-9348, Cl，CH3, Cl, 4-F-Ph, CH3), (M-9349, Cl, CH3, Cl, 4-CF3-Ph，Η), (M-9350, Cl, CH3, Cl, 4-CF3-Ph, Cl), (M-9351, Cl, CH3, Cl, 4-CF3-Ph, F), (M-9352, Cl，CHs, Cl, 4-CF3-P1i, CF3), (M-9353, Cl, CH3, Cl，4-CF3-Ph, Br), (M-9354, Cl, CH3, Cl, 248 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公爱） 經濟部智慧財產局員工消費合作社印製 1284639 A7 _B7___ 五、發明說明卜〇) 4-CF3-Ph, CH3), (M-9355, Cl, CH3, Cl, 4-(Me)2N-Ph, Η), (M-9356，Cl，CH3, Cl， 4-(Me)2N-Ph, Cl), (M-9357, Cl, CH3, Cl, 4-(Me)2N-Ph, F), (Μ·9358, Cl，CH3, Cl， 4-(Me)2N-Ph, CF3), (M-9359, Cl, CH3, Cl，4-(Me)2N-Ph, Br), (M-9360, Cl, CH3, Cl, 4·(Μθ>2Ν·Ρ1ι, CH3), (M-9361, Cl, CH3, Cl, 4-OH-Ph, Η), (M-9362, Cl, CH3, Cl， 4-OH-Ph, Cl), (M-9363, Cl, Clh, dl, 4-OU-Ph, F)，（Μ·93ϋ4,（几 CMla, (Jl, 4-(川· Ph, CF3), (M-9365, Cl, CH3, Cl, 4-OH-Ph, Br), (M-9366, Cl, CH3, Cl, 4-OH-Ph， CH3), (M-9367, Cl, CH3, Cl, 3,4-di-F-Ph, Η), (M-9368, Cl，CH3, Cl，3,4-di-F-Ph， Cl), (M-9369, Cl, CH3, Cl, 3,4-di-F-Ph, F), (Μ·9370, Cl，CH3, Cl, 3,4-di-F-Ph， CF3), (M-9371, Cl, CH3, Cl, 3,4-di-F-Ph, Br), (M-9372, Cl，CH3, Cl, 3,4-di-F-Ph， CH3), (M-9373, Cl, CHa, Cl, 4-COOH-Ph, Η), (M-9374, Cl, CH3, Cl, 4-COOH-Ph, Cl), (M-9375, Cl, CH3, Cl, 4-C00H-Ph, F), (M-9376, Cl, CH3, Cl, 4-C00H-Ph， CF3), (M-9377, Cl, CH3, Cl, 4-C00H-Ph, Br), (M-9378, Cl, CH3, Cl, 4-C00H-Ph, CH3), (M-9379, Cl, CH3, Cl, Bn, Η), (Μ·9380, Cl, CH3, Cl, Bn，Cl)，（M-9381, Cl，CH3, Cl, Bn, F), (M-9382, Cl, CH3, Cl, Bn, CF3), (M-9383, Cl, CH3, Cl, Bn， Br), (M-9384, Cl, CH3, Cl, Bn, CH3), (M-9385, Cl, CH3, Cl, 4-F-Bn, H)，（M-9386, Cl, CH3, Cl, 4-F-Bn, Cl), (M-9387, Cl, CH3, Cl, 4-F-Bn, F), (M-9388, Cl，CH3, Cl， 4-F-Bn, CFa), (M-9389, Cl, CHs, Cl, 4-F-Bn, Br), (M-9390, Cl, CH3, Cl, 4-F-Bn, CH3), (M-9391, Cl, CH3, Cl, 2-Py, Η), (M-9392, Cl, CH3, Cl, 2-Py, Cl), (M-9393, Cl, CHa, Cl, 2-Py, F), (M-9394, Cl, CHs, Cl, 2-Py, CF3), (M-9395, Cl, CHa, Cl, 2-Py, Br), (M-9396, Cl, CH3, Cl, 2-Py, CH3), (M-9397, Cl, CH3, Cl, 3-Py, H), (M-9398, Cl, CH3, Cl, 3:Py, Cl), (M-9399, Cl, CH3, Cl，3-Py, F)，（M-9400, Cl， CH3, Cl, 3-Py, CFs), (M-9401, Cl, CHa, Cl, 3-Py, Br), (M-9402, Cl, CH3, Cl, 3-Py, CHs), (M-9403, Cl, CH3, Cl, 4-Py, Η), (M-9404, Cl, CH3, Cl, 4-Py, Cl), (M-9405, Cl, CH3, Cl, 4-Py, F), (M-9406, Cl, CH3, Cl, 4-Py, CF3), (M-9407, Cl，CH3, Cl, 4-Py, Br), (M-9408, Cl, CH3, Cl, 4-Py, CH3), (M-9409, Cl, CH3, Cl, 2-Th, H), (M-9410, Cl, CH3, Cl, 2-Th, Cl), (M-9411, Cl, CHa, Cl, 2-Th, F), (M-9412, Cl 249 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ------·-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 __B7___ 五、發明說明卜W) (請先閱讀背面之注意事項再填寫本頁) CHa, Cl, 2-Th, CFa), (M-9413, Cl, CH3, Cl, 2-Th, Br), (M-9414, Cl, CHa, Cl, 2-Th, CHa), (M-9415, Cl, CHs, Cl, 3-Th, Η), (M-9416, Cl, CHa, Cl, 3-Th, Cl), (M-9417, Cl, CHa, Cl, 3-Th, F), (M-9418, Cl, CH3, Cl, 3-Th, CFa), (M-9419, Cl, CHa, Cl, 3-Th, Br), (M-9420, Cl, CH3, Cl, 3-Th，CH3), (M-9421, Cl, CH3, Cl, 吡唑-2-棊，Η), (M-9422, Cl，Cii3, Cl,吡唑-2_基，Ul), (Μ·ί)42;】，UUJIh, 1)1， 吡唑-2-基，F), (M-9424, Cl, CH3, Cl, j|t 唑-2-基，CF3), (Μ·9425, Cl, CH3, Cl,吡唑-2 -基，Br), (M-9426, Cl, CH3, Cl,吡唑-2 -基，CH3)，（M-9427, Cl, CH3, Cl,吡唑-3 -基[,Η), (M-9428, Cl, CH3, Cl，妣唑-3 -基，Cl), (M-9429, Cl， CHa, Cl,吡唑-3-基；F), (M-9430, Cl, CH3, Cl,吡唑-3·基，CF3), (Μ·9431, Cl, CH3, Ci,吡唑-3-基，Br), (M-9432, Cl, CH3, Cl,吡唑-3-基？（^3)，（肘-9433, Cl，CH3, Cl,嘧啶-2-基，Η), (M-9434, Cl, CH3, Cl,嘧啶-2-基，Cl), (M-9435, Cl, CH3, Cl,嘧啶-2-基，F), (M-9436, Cl, CH3, Cl,嘧啶-2-基, CF3)，（M-9437, Cl, CH3, Cl,嘧啶-2-基1, Br), (M-9438, Cl, CH3, Cl, 嘧啶-2-基，CH3), (M-9439, Cl, CH3, Cl,嘧啶-4-基，Η), (M-9440, Cl， CH3, Cl,嘧啶-4 -棊，Cl), (M-9441, Cl, CH3, Cl,嘧啶：4 -基，F), (M-9442, Cl, CH3, Cl,嘧啶-4-基，CF3), (M_9443, Cl, CH3, Cl,嘧啶-4-基 1, Br), (M-9444, Cl, CHs, Cl,嘧啶-4-基，CH3), (M-9445, Cl, CH3, Cl,嘧啶-5· 基,Η), (M-9446, Cl, CH3, Cl,喷啶-5-基，Cl), (M-9447, Cl, CH3, Cl, 嘧啶-5 -基，F), (M-9448, Cl, CH3, Cl,嘧啶-5 -基，CF3), (M-9449, Cl, CH3, Cl,嘧啶-5·基，Br), (M-9450, Cl, CH3, Cl,嘧啶-5-基，（^3)，（1^· 9451, Cl, CH3, Cl, HOOCCH2CH2CH2, Η), (M-9452, Cl, CH3, Cl， HOOCCH2CH2CH2, Cl), (M-9453, Cl, CHa, Cl, HOOCCH2CH2CH2, F), (M-9454, Cl, CHa, Cl, HOOCCH2CH2CH2, CF3), (M-9455, Cl, CH3, Cl, HOOCCH2CH2CH2, Br), (M-9456, Cl, CHa, Cl, HOOCCH2CH2CH2, CHa), (M-9457, Cl, CHa, Cl, HOOCCH2CH2CH2CH2, Η), (M-9458, Cl, CH3, Cl, HOOCCH2CH2CH2CH2, Cl), (M-9459, Cl, CH3, Cl, HOOCCH2CH2CH2CH2, F), (M-9460, Cl, CH3, Cl, 250 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） A7 1284639 ______B7 _ 五、發明說明（47 ) HOOCCH2CH2CH2CH2, CF3), (M-9461, Cl, CH3, Cl, HOOCCH2CH2CH2CH2, Br)， (M-9462, Cl, CHa, Cl, HOOCCH2CH2CH2CH2, CHa), (M-9463, Cl, CHa, Cl, (Me)2NCOCH2CH2CH2CH2, Η), (M-9464, Cl, CH3, Cl, (Me)2NCOCH2CH2CH2CH2, Cl), (M-9465, Cl, CH3, Cl, (Me)2NC0CH2CH2CH2CH2, F), (M-9466, Cl, CII3, Cl, (Me)2NCOCH2CH2CH2CH2, CF3), (M-9467, Cl, CH3, Cl, (Me)2NCOCH2CH2CH2CH2, Br), (M-9468, Cl, CH3, Cl, (Me)2NCOCH2CH2CH2CH2, CH3), (M-9469, Cl, CH3, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-9470, Cl, CH3, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-9471, Cl, CH3, Cl, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-9472, Cl, CH3, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-9473, Cl, CH3, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-9474, Cl, CH3, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-9475, Cl, CH3, Cl, MeOCH2, H)，（M· 9476, Cl, CH3, Cl, MeOCH2, Cl), (M-9477, Cl, CH3, Cl, MeOCH2, F), (M-9478, Cl， CHs, Cl, MeOCH2, CF3), (M-9479, Cl, CH3, Cl, MeOCH2, Br), (M-9480, Cl, CH3, Cl，MeOCH2, CH3), (M-9481, Cl, CH3, Cl, EtOCH2, Η), (M-9482, Cl, CH3, Cl， EtOCH2, Cl), (M-9483, Cl, CH3, Cl, EtOCH2, F), (M-9484, Cl, CHa, Cl, EtOCH2, CFa), (M-9485, Cl, CH3, Cl, EtOCH2, Br), (M-9486, Cl, CHa, Cl, EtOCH2, CHa), (M-9487, Cl, CH3, Cl, EtOCH2CH2, Η), (M-9488, Cl, CHa, Cl, EtOCH2CH2, Cl), (M-9489, Cl, CHa, Cl, EtOCH2CH2, F), (M-9490, Cl, CH3, Cl, EtOCH2CH2, CFa), (M-9491, Cl, CH3, Cl, EtOCH2CH2, Br), (M-9492, Cl, CH3, Cl, EtOCH2CH2， CH3), (M-9493, Cl, CH3, Cl, MeOCH2CH2〇CH2CH2, H)，（M-9494, Cl，CHa，Cl， MeOCH2CH2〇CH2CH2, Cl), (M-9495, Cl, CH3, Cl, MeOCH2CH2OCH2CH2, F)， (M-9496, Cl, CH3, Cl, MeOCII2CH2〇CH2CH2, CF3), (M-9497, Cl，CH3, Cl， MeOCH2CH2〇CH2CH2, Br)，（M-9498, Cl, CH3, Cl, MeOCH2CH2〇CH2CH2, CH3)， 251 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -------------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 _____B7_ 五、發明說明（>奸） (M-9499, Cl, CH3, Cl, MeOCH2CH2, Η), (M-9500, Cl, CH3, Cl, MeOCH2CH2, C1)， (M-9501, Cl, CH3, Cl, MeOCH2CH2, F), (Μ·9502, Cl, CH3, Cl，MeOCH2CH2， CF3), (M-9503, Cl, CH3, Cl, MeOCH2CH2, Br), (M-9504, Cl，CH3, Cl， MeOCH2CH2, CH3), (M-9505, Cl, CH3, Cl, HOCH2, Η), (M-9506, Cl，CH3, Cl, HOCH2, Cl), (M-9607, Cl, Cil3, Ci, HOClh, F), (Μ-ϋ508, Cl, Clla, Cl, HOCH2, CF3), (M-9509, Cl, CHa, Cl, HOCH2, Br), (M-9510, Cl, CHa, Cl, HOCH2, CHa), (M-9511, Cl, CH3, Cl, HOCH2CH2, Η), (M-9512, Cl, CH3, Cl, HOCH2CH2, Cl), (M-9513, Cl, CH3, Cl, HOCH2CH2, F), (M-9514, Cl, CHa, Cl, HOCH2CH2, CFa), (M-9515, Cl, CHs, Cl, HOCH2CH2, Br), (M-951G, Cl, CH3, Cl, HOCH2CH2, CH3), (M-9517, Cl, GHa, Cl, HOCH2CH2CH2, Η), (M-9518, Cl, CH3, Cl, HOCH2CH2CH2, Cl), (M-9519, Cl, CHa, Cl, HOCH2CH2CH2, F), (M-9520, Cl, CHa, Cl, HOCH2CH2CH2, CFs), (M-9521, Cl, CHa, Cl, HOCH2CH2CH2, Br), (M-9522, Cl, CH3, Cl, HOCH2CH2CH2, CHa), (M-9523, Cl, CHa, Cl, HOCH2CH2CH2CH2, Η), (M-9524, Cl, CHa, Cl, HOCH2CH2CH2CH2, Cl), (M-9525, Cl, CHa, Cl, HOCH2CH2CH2CH2, F), (M-9526, Cl, CHa, Cl, HOCH2CH2CH2CH2, CFs), (M-9527, Cl, CHa, Cl, HOCH2CH2CH2CH2, Br), (M-9528, Cl, CH3, Cl, HOCH2CH2CH2CH2, CHa), (M-9529, Cl, CHa, Cl, HOCH2CH2CH2CH2CH2, Η), (M-9530, Cl, CHs, Cl, HOCH2CH2CH2CH2CH2, Cl), (M-9531, Cl, CHs, Cl, HOCH2CH2CH2CH2CH2, F), (M-9532, Cl, CH3, Cl, HOCH2CH2CH2CH2CH2, CF3), (M-9533, Cl, CH3, Cl, HOCH2CH2CH2CH2CH2, Br), (M-9534, Cl, CHa, Cl, HOCH2CH2CH2CH2CH2, CHa), (M-9535, Cl, CHa, Cl, HOCH2CH2OCH2CH2, Η), (M-9536, Cl, CIIs, Cl, HOCH2CH2OCH2CH2, Cl), (M-9537, Cl, CH3, Cl, HOCH2CH2OCH2CH2, F), (M-9538, Cl, CH3, Cl, HOCH2CH2OCH2CH2, CF3), (M-9539, Cl, CH3, Cl, HOCH2CH2OCH2CH2, Br), (M-9540, Cl, CHa, Cl, HOCH2CH2OCH2CH2, CHa), (M-9541, Cl, CHa, Cl, (Me)2N, Η), (M-9542, Cl, CHa, Cl, (Me)2N, Cl), (M-9543, Cl, CH3, Cl, (Me)2N, F), (M- 252 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ---1-----------------訂--------- (請先閱讀背面之注意事項再填寫本頁) A7 1284639 _____B7 __ 五、發明說明卜幻） 9544, Cl, CH3, Cl, (Me)2N, CFa), (M-9645, Cl, CHa, Cl, (Me)2N, Br), (M-9546, Cl, CH3, Cl，（Me)2N, CH3), (M-9547, Cl, CH3, Cl,哌啶-4 -基甲基，《[)，（1^-9548, Cl，CH3, Cl,哌啶-4-基甲基> Cl), (Μ·9549, Cl，CH3, Cl,哌啶-4-基甲基yl, F), (M-9550, C1，CH3, Cl,哌啶-4-基甲基，CF3), (M-9551, Cl, CH3, Cl,丨哌啶-4 ·基甲基，Ur), (M-U/352,(〕丨，C：丨，哌啶-4 -基 甲基，CH3)，（M-9553, Cl, CH3, Cl,環己基甲基，Η), (M-9554, Cl，CHs，Cl, 環己基甲基，Cl), (M-9555, Cl, CH3, Cl,環己基甲基，F), (M-9556, Cl， CH3, Cl,環己基甲基，CF3), (M-9557, Cl, CH3, Cl,環己基甲棊，Br)， (M-9558, Cl, CH3, Cl,環己基甲基，CH3), (M-9559, CH3, Η, Η, H，H)， (M-9560, CH3, Η, Η, H, Cl), (M-9561, MeO, Η, Η, H, F), (M-9562, MeO, Η, H，H， CF3), (M-9563, CH3, Η, Η, H, Br), (M-9564, CHs, Η, Η, H, CH3), (M-9565, MeO, Η, H, F, Η), (M-9566, CHa, Η, H, F, Cl), (M-9567, MeO, F, H, F, F), (M-9568, CHa, Η, H, F, CFa), (M-9569, CH3, Η, H, F, Br), (M-9570, CHa, Η, H, F, CH3), (M-9571, CHa, Η, H, Cl, Η), (M-9572, MeO, F, Η, H, i-Pr), (M-9573, CH3, Η, H， Cl, F), (Μ·9574, CH3, Η, H, Cl, CF3), (M-9575, CH3, Η, H, Cl, Br), (M-9576, CH3, Η, H, Cl, CH3), (M-9577, CH3, Η, H, CH3, Η), (M-9578, CH3, Η, H，CH3, Cl)， (M-9579, CH3, Η, H, CH3, F), (M-9580, CH3, Η, H, CH3, CF3), (M-9581，CH3, H, H,CH3,Br),(M-9582,CH3,H,H,CH3,CH3),(M-9583,CH3,H,H,Et,H)，（M-9584, CH3, Η, H, Et, Cl), (M-9585, CH3, Η, H, Et, F), (M-9586, CH3, H，H，Et, CFs), (M-9587, CHa, Η, H, Et, Br), (M-9588, CHa, Η, H, Et, CHa), (M-9589, CHs, Η, H, n-Pr, Η), (M-9590, CHa, Η, H, n-Pr, Cl), (M-9591, CHa, Η, H, n-Pr, F), (M-9592, CH3, Η, H, n-Pr, CF3), (M-9593, CH3, Η, H, n-Pr, Br)，（M-9594, CH3, H, H, n-Pr, CH3), (M-9595, CH3, Η, H, c-Pr, Η), (M-9596, CH3, Η, H, c-Pr, Cl)· (M-9597, CH3, Η, H, c-Pr, F), (M-9598, CH3, Η, H, c-Pr, CF3), (M-9599, CH3, H， H, c-Pr, Br>, (M-9600, CH3, Η, H, c-Pr, CH3), (M-9601, CH3, Η, H, i-Pr, H)， (M-9602, CH3, Η, H, i-Pr, Cl), (M-9603, CH3, Η, H, i-Pr，F)，（M-9604, CH3, H，H， 253 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -------------------訂--------- (請先閱讀背面之注音？事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 經濟部智慧財產局員工消費合作社印製 Α7 Β7 五、發明說明（ο) i-Pr,CF3),(M-9605,CH3,H,H,i-Pr，Br),(M-9606,CH3,H,H，i-Pr，CH3),(M· 9607, CH3, Η, Η, η-Βιχ, Η), (M-9608, CH3, Η, H，n-Bu, Cl), (Μ·9609, CH3, Η, Η, π-Bu, F), (Μ-9610, CHs, Η, Η, n-Bu, CFa), (Μ-9611, CHa, Η, Η, n-Bu, Br), (Μ-9612, CH3, Η, Η, η·Βιι, CH3), (Μ-9613, CH3, Η, Η, i-Bu, Η), (Μ·9614, CH3, Η，Η, i-Bu, Cl), (Μ-9615, CHa, Η, Η, i-Bu, F), (Μ-9616, CHa, Η, Η, i-Bu, CF3), (Μ-9617, CHa, Η, Η, i-Bu, Br), (Μ-9618, CHa, Η, Η, i-Bu, CHa), (Μ-9619, CHa, Η, Η, sec-Bu, Η), (Μ-9620, CH3, Η, Η, sec-Bu, Cl), (Μ-9621, CH3, Η, Η, sec-Bu, F), (Μ-9622, CH3, Η, Η, sec-Bu, CF3), (Μ-9623, CH3, Η, Η, sec-Bu，Br)，（Μ-9624， CH3, Η, Η, sec-Bu, CH3), (Μ-9625, CH3, Η, Η, n-Pen, Η)，（Μ-9626, CH3, Η, Η, n-Pen, Cl), (Μ-9627, CHa, Η, Η, n-Pen, F), (Μ-9628, CHs, Η, Η, n-Pen, CFa), (Μ-9629, CH3, Η, Η, n-Pen, Br), (Μ-9630, CH3, Η, Η, n-Pen, CH3), (Μ-9631, CH3, Η, Η, c-Pen, Η), (Μ-9632, CHs, Η, Η, c-Pen, Cl), (Μ-9633, CHa, Η, Η, c-Pen, F), (Μ-9634, CHa, Η, Η, c-Pen, CFa), (Μ-9635, CHa, Η, Η, c-Pen, Br), (Μ-9636, CHa, Η, Η, c-Pen, CHa), (Μ-9637, CHa, Η, Η, n-Hex, Η), (Μ-9638, CHs, Η, Η, n-Hex, C1), (Μ·9639, CH3, Η, Η, n-Hex, F), (Μ-9640, CH3, Η, Η, n-Hex, CF3), (Μ-9641, CH3, Η, Η, n-Hex, Br), (Μ-9642, CH3, Η, Η, n-Hex, CH3), (Μ-9643， CH3, Η, Η, c-Hex, Η), (Μ-9644, CH3, Η, Η, c-Hex, Cl), (Μ-9645, CH3, Η, Η, c· Hex, F), (Μ-9646, CH3, Η, Η, c-Hex, CF3), (Μ-9647, CH3, Η, Η, c-Hex, Br), (Μ-9648, CH3, Η, Η, c-Hex, CH3), (Μ-9649, CH3, Η, Η, OH, Η), (Μ-9650, CH3, Η, Η, OH, Cl), (Μ-9651, CH3, Η, Η, OH, F), (Μ-9652, CH3, Η, Η，ΟΗ，CFa), (Μ-9653, CH3, Η, Η, OH, Br), (Μ-9654, CH3, Η, Η, OH, CH3), (Μ·9655, CH3, Η，Η, EtO, Η), (Μ-9656, CH3, Η, Η, EtO, Cl), (Μ-9657, CH3, Η，Η, EtO, F), (Μ-9658, CH3, Η, Η, EtO, CF3), (Μ-9659, CH3, Η, Η, EtO, Br), (Μ-9660, CH3, Η，Η, EtO, CH3)， (Μ·9661, CH3, Η, Η, n-PrO, Η), (Μ-9662, CH3, Η, Η, n-PrO, Cl), (Μ-9663, CH3, Η, Η, n-PrO, F), (Μ-9664, CH3, Η, Η, n-PrO, CF3), (Μ·9665, CH3, Η, Η，n-PrO, Br), (Μ-9666, CHa, Η, Η, n-PrO, CHa), (Μ-9667, CH3, Η, Η, PhO, Η), (Μ-9668, 254 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --^----:-------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 ____B7 ____ 五、發明說明（W) CHa, Η, H, PhO, Cl), (M-9669, CHs, Η, H, PhO, F), (M-9670, CHa, Η, H, PhO, CF3), (M-9671, CH3, Η, H, PhO, Br), (M-9672, CH3, Η, H, PhO, CH3), (M-9673, CH3, Η, Η, BnO, Η), (M-9674, CH3, Η, H, BnO, Cl), (M-9675, CH3, Η, H, BnO, F), (M-9676, CH3, Η, H, BnO, CF3), (M-9677, CH3, Η, H，BnO, Br)，（M-9678, CH3. H· H, BnO, CH3), (M-9679, CH3, Η, H, PI1CH2CH2O, Η), (M-9680, CH3, Η, H, PhCH2CH2〇, Cl), (M-9681, CH3, Η, H, PhCH2CH2〇, F)，（M-9682, CH3, Η, H, PhCH2CH2〇, CF3), (M-9683, CHa, Η, H, PhCH2CH2〇, Br), (M-9684, CH3> Η, H, PhCH2CH2〇, CH3), (M-9685, MeO, Η, H, CF3〇, Η), (M-9686, CH3, H，H，CF3〇, Cl), (Μ·9687, CH3, Η, H, CF3〇, F), (M-9688, CH3, Η, H, CF3〇, CFs), (M-9G89， CH3, Η, H, CF3〇, Br), (M-9690, CH3, Η, H, CF3〇, CH3), (M-9691, CH3, H，H, Ph， Η), (M-9692, CH3, Η, H, Ph, Cl), (M-9693, CH3, Η, H, Ph, F), (M-9694, CH3, H， H, Ph, CF3), (M-9695, CHs, Η, H, Ph, Br), (M-9696, CHa, Η, H, Ph, CHa), (M-9697, CH3, Η, H, 4-F-Ph, Η), (M-9698, CH3, Η, H, 4-F-Ph, Cl), (M-9699, CH3, H， H, 4-F-Ph, F), (M-9700, CH3, Η, H, 4-F-Ph, CF3), (M-9701, CH3, Η, H, 4-F-Ph， Br), (M-9702, CH3, Η, H, 4-F-Ph, CH3), (M-9703, CH3, Η, H，4-CF3-Ph，H), (M-9704, CH3, Η, H, 4-CF3-Ph, Cl), (M-9705, CH3, Η, H, 4-CF3-Ph, F), (M-9706, CH3, Η, H, 4-CF3-Ph, CF3), (M-9707, CH3, Η, H, 4-CF3-Ph, Br), (M-9708, CH3, H, H, 4-CFa-Ph, CH3), (M-9709, CH3, Η, H, 4-(Me)2N-Ph, Η), (M-9710, CH3, H，H， 4-(Me)2N-Ph, Cl), (M-9711, CH3, H，H, 4-(Me)2N-Ph, F)，（M-9712, CH3, Η, H， 4-(Me)2N-Ph, CF3), (M-9713, CH3, Η, H, 4-(Me)2N-Ph, Br), (M-9714, CH3, Η，H， 4-(Me)2N-Ph, CHa), (M-9715, CHa, Η, H, 4-OH-Ph, Η), (M-9716, CHa, Η, H, 4-OH-Ph, Cl), (M-9717, CH3, Η, H, 4-OH-Ph, F), (M-9718, CH3, Η, H, 4-OH-Ph， CF3), (M-9719, CH3, Η, H, 4-OH-Ph, Br), (M-9720, CH3, Η, H, 4-OH-Ph，CH3)， (M-9721, CH3, Η, H, 3,4-di-F-Ph, Η), (M-9722, CH3, Η, H，3,4-di-F-Ph，Cl)， (M-9723, CH3, Η, H, 3,4-di-F-Ph，F), (M-9724, CH3, Η, H，3,4-di-F-Ph，CFs>, (M-9725, CHa, Η, H, 3,4-di-F-Ph, Br), (M-9726, CH3, Η, H, 3,4-di-F-Ph，CH3)， 255 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 胃 (請先閱讀背面之注意事項再填寫本頁) 1T--------- 經濟部智慧財產局員工消費合作社印製 A7 1284639 B7__ 五、發明說明（〜） (M-9727, CH3, Η, H, 4-COOH-Ph, Η), (M-9728, CH3, Η, H, 4-COOH-Ph, Cl), (M-9729, CH3, Η, H, 4-COOH-Ph, F), (M-9730, CH3, Η, H, 4-COOH-Ph, CF3), (M-9731, CH3, Η, H, 4-COOH-Ph, Br), (M-9732, CH3, Η, H, 4-COOH-Ph，CH3)， (M-9733, CH3, Η, Η, Bn, Η), (M-9734, CH3, H，H, Bn, Cl)，（M-9735, CH3, H，H, Bn, F), (M-9736, CHa, Η, H, Bn, CFa), (M-9737, CHa, Η, H, Bn, Br), (M-9738, CHa, Η, H, Bn, CHs), (M-9739, CHa, Η, H, 4-F.Bn, Η), (M-9740, CH3, Η, H, 4-F-Bn, Cl), (M-9741, CH3, Η, H, 4-F-Bn, F), (M-9742, CH3, H，H, 4-F-Bn, CF3), (M-9743, CHa, Η, H, 4-F-Bn, Br), (M-9744, CHa, Η, H, 4-F-Bn, CHa), (M-9745, CH3, Η, H, 2-Py, Η), (M-9746, CHa, Η, H, 2-Py, Cl), (M-9747, CH3, Η, H, 2-Py， F), (M-9748, CH3, Η, H, 2-Py，CF3), (M-9749, CH3, Η, H, 2-Py, Br), (M-9750, CHs, Η, H, 2-Py, CHs), (M-9751, CHa, Η, H, 3-Py, Η), (M-9752, CH3, Η, H, 3-Py, Cl), (M-9753, CH3, Η, H, 3-Py, F), (M-9754, CH3, Η, H, 3-Py, CF3), (M-9755, CH3,H,H,3-Py,Br)，（M-9756,CH3,H,H,3-Py,CH3),(M-9757,CH3,H，H，4· Py, Η), (M-9758, CH3, Η, H, 4-Py, Cl), (M-9759, CH3, Η, H, 4-Py, F), (M-9760, CH3, Η, H, 4-Py, CFs), (M-9761, CHa, Η, H, 4-Py, Br), (M-9762, CHa, Η, H, 4-Py, CH3), (M-9763, CH3, Η, H, 2-Th, Η), (M-9764, CH3, Η, H, 2-Th, Cl), (M-9765, CH3, Η, H, 2-Th, F), (M-9766, CH3, Η, H, 2-Th, CF3), (M-9767, CH3, Η, H, 2-Th， Br)，（M-9768, CH3, Η, H, 2-Th, CH3), (M-9769, CH3, H，H, 3-Th，H)，（M-9770, CH3, Η, H, 3-Th, Cl), (Μ·9771，CH3, Η, H, 3-Th, F), (M-9772, CH3, Η, H，3-Th， CF3), (M-9773, CH3, Η, H, 3-Th, Br), (M-9774, CH3, Η, H, 3-Th，CH3)，（M-9775, CH3, Η, H,吡唑-2-基，Η), (M-9776, CH3, Η, H,吡唑-2-基，Cl), (M-9777, CH3, Η, H,吡唑-2-棊，F), (M-9778, CH3, Η, H，吡唑-2-基，CF3)，（M-9779, CH3, Η, H,吡唑-2-基 Br), (M-9780, CH3, Η, H,吡唑-2-基，CH3), (M· 9781, CH3, Η, H,吡唑-3-基，H), (M-9782，CH3, Η, H，吡唑-3-基丨，Cl), (Μ·9783, CH3, Η, H,吡唑-3 基丨，F), (M_9784, CH3, Η, H,吡唑-3 -棊 1, CF3)， (Μ·9785, CH3, Η, H,吡唑-3 _ 基,Br), (M-9786, CH3, Η, H,吡哗-3 -基， __ 256 _ 本紙張尺度適用中國國家標準(CNS)A4規格（210 x 297公釐） ： ---：---·--------- ----訂--------- (請先閱讀背面之注咅？事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 A7 1284639 _：____B7___ _ 五、發明說明（zr) CH3)，（M-9787, CH3, Η, Η, _ 陡-2-棊，Η), (M-9788, CH3, Η, H， 嘧啶-2 -基，Cl), (Μ-9789, CH3, Η, Η,嘧啶-2 -基！，F), (Μ-9790, CH3, Η, Η, ·嘧啶-2-基，CF3), (M-9791, CH3, Η, H，嘧啶-2-棊 Br), (M-9792, CH3, Η, H,嘧啶·2·基，CH3), (M-9793, CH3, H，H,嘧啶-4-基，H)，（Μ·9794, CH3, Η, H，嘧啶-4-基，Cl), (M.9795, CH3, Η, H,嘧啶-4-基，1〇,(1^· 9796, CH3, Η, Η,嘧啶-4 -基，CF3), (M-9797, CH3, Η, Η,丨嘧啶-4 -基,Br)， (Μ·9798, CH3, Η, Η,嘧啶· 4 _ 基，CH3), (M-9799, CH3, Η, Η,嘧啶-5 基， Η), (M-9800, CH3, Η, Η,嘧啶-5-基，Cl), (M-9801, CH3, Η，Η,嘧啶-5-基，F), (Μ-9802, CH3, Η, Η,嘧啶-5-基，CF3), (Μ-9803, CH3, Η，Η, 嘧啶-5 -基，Br), (Μ-9804, CH3, Η, Η,嘧啶-5 -基，CH3), (Μ·9805, CH3, Η, H, HOOCCH2CH2CH2, Η), (Μ-9806, CH3, Η, Η, HOOCCH2CH2CH2, C1), (Μ-9807, CHa, Η, Η, HOOCCH2CH2CH2, F), (Μ-9808, CH3, Η, Η, HOOCCH2CH2CH2, CFs), (Μ-9809, CHs, Η, Η, HOOCCH2CH2CH2, Br), (Μ-9810, CHa, Η, Η, HOOCCH2CH2CH2, CHs), (Μ-9811, CH3, Η, Η, HOOCCH2CH2CH2CH2, Η), (Μ-9812, CHs, Η, Η, HOOCCH2CH2CH2CH2, C1), (Μ-9813, CH3, Η, Η, HOOCCH2CH2CH2CH2, F), (Μ-9814, CH3, Η, Η, HOOCCH2CH2CH2CH2, CF3), (Μ-9815, CHs, Η, Η, HOOCCH2CH2CH2CH2, Br), (Μ-9816, CHa, Η, Η, HOOCCH2CH2CH2CH2, CH3), (Μ-9817, CH3, Η, Η, (Me)2NCOCH2CH2CH2CH2, Η), (Μ-9818, CH3, Η，Η, (Me>2NCOCH2CH2CH2CH2, Cl), (Μ-9819, CH3, Η, Η, (Me)2NCOCH2CH2CH2CH2, F), (Μ-9820, CH3, Η, Η, (Me)2NCOCH2CH2CH2CH2, CF3>, (Μ-9821, CH3, Η, Η, (Me)2NCOCH2CH2CH2CH2, Br), (Μ-9822, CH3, Η，Η， (Me)2NCOCH2CH2CH2CH2, CH3), (Μ-9823, CH3, Η, Η, (Me)2NCOCH2CH2CH2CH2CH2, Η), (Μ-9824, CH3, II，Η, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (Μ-9825, CH3, Η, Η， (Me)2NCOCH2CH2CH2CH2CH2, F), (Μ-9826, CH3, Η, Η, 257 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ---1-----------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 Δ7 Α7 _ Β7__ 五、發明說明（W ) (Me)2NCOCH2CH2CH2CH2CH2, CF3), (Μ·9827, CH3, Η, Η, (Me)2NCOCH2CH2CH2CH2CH2, Br), (Μ-9828, CH3, Η, Η, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (Μ-9829, CH3, Η, Η，MeOCH2, Η), (Μ-9830, CH3, Η, Η, MeOCH2, Cl), (Μ·9831, CH3, Η, Η, MeOCH2, F)，（Μ-9832, CH3, Η, Η, MeOCHa, CFs), (Μ-9833, CHa, Η, Η, MeOCH2, Br), (Μ-9834, Oils, Η, II, MeOCH2, CH3), (Μ-9835, CH3, Η, Η, EtOCH2, Η)，（Μ-9836, CH3, Η, Η, EtOCH2， Cl), (Μ-9837, CHs, Η, Η, EtOCH2, F), (Μ-9838, CHa, Η, Η, EtOCH2, CFa), (Μ-9839, CHa, Η, Η, EtOCH2, Br), (Μ-9840, CHa, Η, Η, EtOCH2, CHa), (Μ-9841, CH3, Η, Η, EtOCH2CH2, Η), (Μ-9842, CH3, Η, Η, EtOCH2CH2, C1)，（Μ·9843、 CH3, Η, Η, EtOCH2CH2, F), (Μ-9844, CH3, Η, Η, EtOCH2CH2, CF3), (Μ-9845， CH3, Η, Η, EtOCH2CH2, Br), (Μ-9846, CH3, Η, Η，EtOCH2CH2, CH3), (Μ-9847, CH3, Η, Η, MeOCH2CH2〇CH2CH2, Η), (Μ-9848, CH3, Η, Η, MeOCH2CH2〇CH2CH2, C1), (Μ·9849, CH3, Η, Η, MeOCH2CH2〇CH2CH2, F)， (Μ-9850, CH3, Η, Η, MeOCH2CH2〇CH2CH2, CF3), (Μ.9851, CH3, Η, Η, MeOCH2CH2〇CH2CH2, Br), (Μ-9852, CH3, Η, Η, MeOCH2CH2〇CH2CH2, CH3)， (Μ-9853, CH3, Η, Η, MeOCH2CH2, Η), (Μ-9854, CH3, Η, Η，MeOCH2CH2, Cl)， (Μ-9855, CH3, Η, Η, MeOCH2CH2, F), (Μ-9856, CH3, Η, Η, MeOCH2CH2, CF3)， (Μ-9857, CH3, Η, Η, MeOCH2CH2, Br), (Μ-9858, CH3, Η, Η, MeOCH2CH2, CH3)， (Μ-9859, CH3, Η, Η, HOCH2, Η), (Μ-9860, CH3, Η, Η, HOCH2, Cl)，（Μ-9861， CH3, Η, Η, HOCH2, F), (Μ-9862, CH3, Η, Η, HOCH2, CF3)，（Μ-9863, CH3, Η，Η, HOCH2, Br), (Μ-9864, CH3, Η, Η, HOCH2, CH3), (Μ·9865, CH3, Η, Η， HOCH2CH2, Η), (Μ-9866, CH3, Η, Η, HOCH2CH2, C1), (Μ·9867, CH3, Η，Η， HOCH2CH2, F), (Μ-9868, CH3, Η, Η, HOCH2CH2, CF3), (Μ-9869, CHs，Η，Η， HOCH2CH2, Br), (Μ-9870, CH3, Η, Η, HOCH2CH2, CH3), (Μ-9871, CH3, Η，Η， HOCH2CH2CH2, Η), (Μ-9872, CHa, Η, Η, HOCH2CH2CH2, Cl), (Μ-9873, CH3, Η, Η, HOCH2CH2CH2, F), (Μ-9874, CHa, Η, Η, HOCH2CH2CH2, CF3), (Μ-9875, 258 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公釐） ----：——.--------- (請先閱讀背面之注意事項再填寫本頁) 訂--- 線# A7 1284639 __B7__ 五、發明說明 CHs, Η, H, HOCH2CH2CH2, Br), (M-9876, CHa, Η, H, HOCH2CH2CH2, CHa), (M-9877, CHs, Η, H, HOCH2CH2CH2CH2, Η), (M-9878, CH3, Η, H, HOCH2CH2CH2CH2, Cl), (M-9879, CHa, Η, H, HOCH2CH2CH2CH2, F), (M-9880, CHa, Η, H, HOCH2CH2CH2CH2, CFa), (M-9881, CHs, Η, H, HOCH2CH2CH2CH2. Br), (M-9882, CH3, Η, H, HOCH2CH2CH2CH2, CHs), (M-9883, CHs, Η, H, HOCH2CH2CH2CH2CH2, Η), (M-9884, CHa, Η, H, HOCH2CH2CH2CH2CH2, Cl), (M-9885, CH3, Η, H, HOCH2CH2CH2CH2CH2, F), (M-9886, CHa, Η, H, HOCH2CH2CH2CH2CH2, CFs), (M-9887, CH3, Η, H, HOCH2CH2CH2CH2CH2, Br), (M-9888, CHa, Η, H, HOCH2CH2CH2CH2CH2, CHs), (M-9889, CII3, Η, H, HOCH2CH2OCH2CH2, Η), (M-9890, CHa, Η, H, HOCH2CH2OCH2CH2, Cl), (M-9891, CHa, Η, H, HOCH2CH2OCH2CH2, F), (M-9892, CHa, Η, H, HOCH2CH2OCH2CH2, CFs), (M-9893, CHa, Η, H, HOCH2CH2OCH2CH2, Br). (M-9894, CH3, Η, H, HOCH2CH2OCH2CH2, CH3), (M-9895, CH3, Η, H, (Me)2N, Η), (M-9896, CH3, Η, H, (Me)2N, Cl), (M-9897, CH3, Η, H, (Me)2N, F), (M-9898, CH3, Η, H, (Me)2N, CF3), (M-9899, CH3, Η, H, (Me)2N, Br), (M-9900, CH3, Η, H， (Me)2N, CH3), (M-9901, CH3, Η, H,哌啶-4 -基甲某，Η), (M-9902, CH3, H, H,哌啶-4·基甲基，C1), (M-9903, CH3, Η, H,哌啶-4-基甲基，F), (M-9904, CH3, Η, H,哌啶 4 -基甲棊，CF3), (M-9905, CH3, Η, H, 哌啶-4 -基甲基，Br), (Μ·99〇6, CH3, Η, H，哌啶-4 -基甲基，CHs), (M-9907, CH3, Η, H,環己基甲基，H>, (M-9908, CH3, Η, H, 環己基甲基，Cl), (M-9909, CH3, Η, H,環己基甲基，F), (M-9910， CH3,H,H,環己基甲基，CF3), (M-9911,CH3,H，H,環己基甲基，Br)， (M-9912, CH3, Η, H,環己基甲基，（^3),(1\1-9913,(^13，1^，11，出，（^4· 9914, CH3, H, F, H，Cl), (M-9915, CH3, H, F, H, F), (M-9916, CH3, H，F, H，CF3)， (Μ-9917, CH3, Η, F, Η, Br), (Μ-9918, CH3, Η, F, Η, CH3), (Μ-9919, CH3, Η，F，F， Η), (M-9920, CH3, H, F, F, Cl), (M-9921, CH3, H，F，F，F)，（M-9922, CH3, H，F， 259 冢紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ' (請先閱讀背面之注咅3事項再填寫本頁) ---------訂---------· 經濟部智慧財產局員工消費合作社印製 1284639 Λ7 __ _B7___ 五、發明說明（4) F, CFs), (M-9923, CHa, H, F, F, Br), (M-9924, CH3, H, F, F, CHa), (M-9925, CHs, H, F, Cl, Η), (M-9926, CH3, H, F, Cl, Cl), (M-9927, CHa, H, F, Cl, F), (M-9928, CH3, H, F, Cl, CF3), (M-9929, CH3, H, F, Cl, Br), (M-9930, CH3, H, F, Cl, CH3), (M-9931, CHa, H, F, CHa, Η), (M-9932, CHa, H, Ft CHn, Cl), (M-9933, CHn, H. F, CH3, F)，（M-9934, CH3, H, F, CH3, CF3), (Μ·993δ, CH3, H, F, CHs, Br), (M-9936, CH3, H，F，CH3, CH3), (M-9937, CH3, H, F, Et, Η), (M-9938, CH3, H, F, Et，Cl)， (M-9939, CH3, H, F, Et, F), (M-9940, CH3, H, F, Et，CF3), (M-9941, CH3, H, F, Et， Br), (M-9942, CH3, H, F, Et, CH3), (M-9943, CH3, H, F, n-Pr, H)，（M-9944, CHs， H，F, n-Pr, Cl), (M-9945, CH3, H, F, n-Pr, F), (M-9946, CH3, H, F，n-Pr，CFs), (M-9947, CH3, H, F, n-Pr, Br), (M-9948, CH3, H, F, n-Pr, CH3), (M-9949, CH3, H， F，c-Pr，H)，（M-9950, CH3, H, F, c-Pr, Cl), (M-9951, CH3, H, F，c-Pr, F>, (M-9952, CH3, H, F, c-Pr, CF3), (M-9953, CH3, H, F, c-Pr, Br), (M-9954, CH3, H，F，c-Pr, CH3), (M-9955, CH3, H, F, i-Pr, Η), (M-9956, CH3, H, F, i-Pr, Cl), (M-9957, CH3, H, F, i-Pr, F), (M-9958, CH3, H, F, i-Pr, CF3), (M-9959, CH3, H，F, i-Pr，Br), (M-9960, CHs, H, F, i-Pr, CHa), (M-9961, CHa, H, F, n-Bu, Η), (M-9962, CHa, H, F, n-Bu, Cl), (Μ·9963, CH3, H, F, n-Bu, F), (M-9964, CH3, H, F, n-Bu, CF3), (M-9965, CH3, H, F, n-Bu, Br), (M-9966, CH3, H, F, n-Bu, CH3), (M-9967, CH3, H, F, i-Bu, Η), (M-9968, CH3, H, F, i-Bu, Cl), (M-9969, CH3, H, F, i-Bu, F), (M-9970, CH3, H, F, i-Bu, CF3), (M-9971, CH3, H, F, i-Bu, Br), (M-9972, CH3, H, F, i-Bu, CHa), (M-9973, CHs, H, F, sec-Bu, Η), (M-9974, CHa, H, F, sec-Bu, CI)r (M-9975, CH3, H, F, sec-Bu, F), (M-9976, CH3, H, F, sec-Bu, CF3), (M-9977, CH3, H, F, sec-Bu, Br), (M-9978, CH3, H, F, sec-Bu, CH3), (M-9979, CH3, H, F, n-Pen, Η), (M-9980, CHs, H, F, n-Pen, Cl), (M-9981, CH3, H, F, n-Pen, F), (M-9982, CH3, H, F, n-Pen, CF3), (M-9983, CH3, H, F, n-Pen, Br), (M-9984, CH3, H, F, n-Pen, CHa), (M-9985, CH3, H, F, c-Pen, Η), (M-9986, CHa, H, F, c-Pen, Cl), (M-9987, CHa, H, F, c-Pen, F), (M-9988, CH3, H, F, c-Pen, CF3), (M-9989, CH3, ___260__ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） -----奢 (請先閱讀背面之注意事項再填寫本頁) 訂---- 經濟部智慧財產局員工消費合作社印製 1284639 經濟部智慧財產局員工消費合作社印製 A7 ____Β7__ 五、發明說明（叫） H, F, c-Pen, Br), (M-9990, CH3, H, F, c-Pen, CH3), (M-9991, CH3, H, F, n-Hex, Η), (M-9992, CH3, H, F, n-Hex, Cl), (M-9993, CH3, H, F, n-Hex, F), (M-9994, CH3, H, F, n-Hex, CF3), (Μ·9995, CH3, H, F, n-Hex, Br), (M-9996, CH3, H, F， n-Hex, CHa), (M-9997, CH3, H, F, c-Hex, Η), (M-9998, CHa, H, F, c-IIox, Cl). (M-9999, CH3, H, F, c-Hex, F), (M-10000, CH3, H, F, c-Hex, CF3), (M-10001, CH3, H, F, c-Hex, Br), (M-10002, CH3, H, F, c-Hex, CH3)，（M-10003, CH3, H, F， OH, Η), (M-10004, CH3, H, F, OH, Cl), (M-10005, CH3, H, F, OH, F)，（M-10006, CH3, H, F, OH, CF3), (M-10007, CH3, H, F, OH, Br), (M-10008, CH3, H, F, OH， CH3), (M-10009, CH3, H, F, EtO, Η), (M-10010, CH3, H, F, EtO, Cl), (M-lOOll， CH3, H, F, EtO, F), (M-10012, CH3, H, F, EtO, CF3), (M-10013, CH3, H, F，EtO, Br), (M-10014, CH3, H, F, EtO, CH3), (M-10015, CH3, H, F, n-PrO, Η), (M-10016, CH3, H, F, n-PrO, Cl), (M-10017, CH3, H, F, n-PrO, F), (M-10018, CH3, H, F, n-PrO, CF3), (M-10019, CH3, H, F, n-PrO, Br), (M-10020, CH3, H, F, n-PrO, CHs), (M-10021, CHs, H, F, PhO, Η), (M-10022, CHa, H, F, PhO, Cl), (M-10023, CH3, H, F, PhO, F), (M-10024, CH3, H, F, PhO, CF3), (M-10025, CH3, H, F, PhO, Br), (M-10026, CHs, H, F, PhO, CHa), (M-10027, CHa, H, F, BnO, Η), (M-10028, CH3, H, F, BnO, Cl), (M-10029, CH3, H, F, BnO, F), (M-10030, CH3, H, F, BnO, CF3), (M-10031, CHs, H, F, BnO, Br), (M-10032, CH3, H, F, BnO, CH3), (M-10033, CH3, H, F, PhCH2CH2〇, Η), (M-10034, CH3, H, F，PhCH2CH2〇, Cl>, (M-10035, CH3, H, F, PhCH2CH20, F), (M-10036, CH3, H, F, PhCH2CH2〇, CF3)， (M-10037, CH3, H, F, PhCH2CH2〇, Br), (M-10038, CH3, H，F, PhCH2CH2〇, CHa), (M-10039, CHa, H, F, CFaO, Η), (M-10040, CHa, H, F, CF3〇, Cl), (M-10041, CH3, H, F, CF3〇, F), (M-10042, CH3, H, F, CF3〇, CF3), (M-10043, CH3, H, F, CF3〇, Br), (M-10044, CH3, H, F, CF3〇, CH3), (M-10045, CH3, H, F, Ph, H)， (M-10046, CH3, H, F, Ph, Cl>, (M-10047, CH3, H, F, Ph, F), (M-10048, CH3, H，F， Ph, CF3), (M-10049, CH3, H, F, Ph, Br), (M-10060, CH3, H, F, Ph, CH3), (M- 261 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -------------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 _B7____ 五、發明說明（〜） 10051, CHa, H, F, 4-F-Ph, Η), (M-10052, CH3, H, F, 4-F-Ph, Cl), (M-10053, CHs, H, F, 4-F-Ph, F), (M-10054, CHa, H, F, 4-F-Ph, CF3), (M-10055, CHa, H, F, 4-F-Ph, Br), (M-10056, CH3, H, F, 4-F-Ph, CH3), (M-10057, CH3, H, F，4-CF3-Ph， Η), (M-10058, CH3, H, F, 4-CF3-Ph, Cl), (M-10059, CH3, H，F, 4-CF3-Ph，F), (M-10060, CHs, H, F, 4-CFa-Ph, CFa), (M-10061, CHa, H, F, 4-CFa-Ph, Br), (M-10062, CH3, H, F, 4-CF3-Ph, CH3), (M-10063, CH3, H, F, 4-(Me)2N-Ph，H), (M-10064, CH3, H, F, 4-(Me)2N-Ph, Cl), (M-10065, CH3, H, F，4-(Me)2N-Ph, F)， (M-10066, CH3, H, F, 4-(Me)2N-Ph, CF3), (M-10067, CH3, H, F, 4-(Me)2N-Ph, Br), (M-10068, CH3, H, F, 4-(Me)2N-Ph, CH3), (M-10069, CH3, II, F, 4-OH-Ph， Η), (M-10070, CH3, H, F，4-OH-Ph, Cl), (M-10071, CH3, H, F, 4-OH-Ph, F), (M-10072, CHs, H, F, 4-OH-Ph, CFs), (M-10073, CHs, H, F, 4-OH.Ph, Br), (M-10074, CHa, H, F, 4-OH-Ph, CHs), (M-10075, CHa, H, F, 3,4-di-F.Ph, Η), (M-10076,CH3,H,F,3,4-di-F-Ph,Cl),(M-10077,CH3,H,F,3,4-di-F-Ph,F),(M· 10078, CH3, H, F, 3,4-di-F-Ph, CF3), (M-10079, CH3, H, F, 3,4-di-F-Ph, Br)， (M-10080, CH3, H，F, 3,4-di-F-Ph, CH3), (M-10081, CH3, H, F, 4-COOH-Ph，H)， (M-10082, CH3, H, F, 4-COOH-Ph, Cl), (M-10083, CH3, H, F, 4-COOH-Ph，F), (M-10084, CH3, H, F, 4-C〇OH-Ph, CF3), (Μ·10085, CH3, H, F, 4-COOH-Ph, Br)， (M-10086, CHs, H, F, 4-COOH-Ph, CHa), (M-10087, CHa, H, F, Bn, Η), (M-10088, CHa, H, F, Bn, Cl), (M-10089, CHa, H, F, Bn, F), (M-10090, GHa, H, F, Bn, CF3), (M-10091, CH3, H, F, Bn, Br), (M-10092, CH3, H, F, Bn, CHs), (M-10093, CH3, H, F, 4-F-Bn, Η), (M-10094, CH3, H, F, 4-F-Bn, Cl)，（M-10095, CH3, H，F, 4-F-Bn, FMM-10096, CH3, H, F, 4-F-Bn, CF3), (M-10097, CH3, H, F，4-F-Bn， Br), (M-10098, CH3, H, F, 4-F-Bn, CH3), (M-10099, CH3, H, F, 2-Py, Η), (M· 10100, CH3, H, F, 2-Py, Cl), (M-10101, CH3, H, F, 2-Py, F), (M-10102, CH3, H，F， 2-Py, CF3)，（M-10103, CH3, H, F，2-Py, Br), (M-10104, CH3, H，F, 2-Py，CH3)， (M-10105, CH3, H, F, 3-Py, Η), (M-10106, CH3, H，F, 3-Py, Cl)，（M-10107, CH3, 262 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） — 1——：-------------訂 i (請先閱讀背面之注意事項再填寫本頁) 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（山） H, F, 3-Py, F), (M-10108, CHa, H, F, 3-Py, CFa), (M-10109, CH3, H, F, 3-Py, Br), (M-10110, CH3, H, F, 3-Py, CH3), (M-10111, CH3, H, F, 4-Py, Η), (M-10112, CH3, H, F, 4-Py, Cl), (M-10113, CH3, H, F，4-Py, F), (M-10114, CH3, H，F, 4-Py, CF3)， (M-10115, CH3, H, F, 4-Py, Br), (Μ·10116, CH3, H，F，4-Py, CH3)，（M-10117， CH3, H, F, 2-Th, Η), (M-10118, CH3, H, F, 2-Th, Cl), (M.10119, CH3, H, F, 2-Th， F)，（M-10120, CH3, H, F, 2-Th, CFs), (M-10121, CH3, H, F, 2-Th，Br), (M-10122, CH3, H, F, 2-Th, CH3), (M-10123, CH3, H, F, 3-Th, Η), (M-10124, CH3, H, F， 3-Th, Cl), (M-10125, CH3, H, F, 3-Th, F), (M-10126, CH3, H, F, 3-Th, CF3)， (M-10127, CHa, H, F, 3-Th, Br), (M-10128, CHa, H, F, 3-Th, CHa), (M-10129, CH3, H, F,吡唑-2-基,H), (M-10130, CH3, H, F,吡唑-2-基，Cl), (M-10131, CH3, H, F,吡唑-2-基，F), (M-10132, CH3, H, F,吡唑-2-基，CF3), (M-10133, CH3, H, F,吡唑-2-基，Br), (M-10134, CH3, H, F,吡唑-2-基，CH3), (M-10135, CH3, H, F,吡唑-3-基,Ii), (M-10136, CH3, H, F,吡唑-3-基，Cl), (M-10137, CH3, H, F,吡唑-3-基,F), (M-10138, CH3, H, F,吡唑-3-基， CF3), (M-10139, CH3, H，F,吡唑-3-碁，Br), (M-10140, CH·% H, F,吡唑-3-基，CH3), (M-10141, CH3, H, F,嘧啶-2 -基，Η), (M-10142, CH3, H, F， 嘧啶 _2-基，Cl), (M-10143, CH3, H, F,嘧啶-2二基，F)，（M-10144, CH3, H， F,嘧啶-2-基，CF3), (M-10145, CH3, H, F,嘧啶-2-棊 1，Br), (M-10146， CH3, H, F,嘧啶-2-基，CH3), (M-10147, CH3, H, F,嘧啶-4-基，H), (M-10148, CH3,H,F,嘧啶·4-基，Cl), (M-10149, CH3, H, F,嚼啶-4·基， F), (M-10150, CH3, H, F,嘧啶-4-基，CF3), (M-10151, CH3, H, F, 嘧啶-4-基，Br), (M-10152, CH3, H, F,嘧啶-4-基.，CH3)，（M-10153, CH3, H, F,嘧啶-5-基，Η), (M-10154, CH3, H, F,嘧啶-5-基，Cl), (M-10155, CH3, H, F,嘧啶-5-基,F), (M-10156, CH3, H, F，嘧啶-5-基，CF3)，（M-10157, CH3, H, F,喃啶-5-基，Br), (M-10158, CH3, H, F，喃 n定-5-棊， CHs), (M-10159, CHs, H, F, HOOCCH2CH2CH2, Η), (M-10160, CHa, H, F, 263 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ---------------- (請先閱讀背面之注意事項再填寫本頁)
ϋ ϋ ϋ I 訂--- 經濟部智慧財產局員工消費合作社印製 1284639 A7 ____B7______ 五、發明說明（^) HOOCCH2CH2CH2, Cl), (M-10161, CHa, Η, F, HOOCCH2CH2CH2, F), (M-101G2, CH3, H, F, HOOCCH2CH2CH2, CFa), (M-10163, CHa, H, F, HOOCCH2CH2CH2, Br), (M-10164, CH3, H, F, HOOCCH2CH2CH2, CH3), (M-10165, CH3, H，F, HOOCCH2CH2CH2CH2, Η), (M-10166, CHa, H, F, HOOCCH2CII2CH2CH2, Cl)、 (M-10167, CHs, H, F, HOOCCH2CH2CH2CH2, F), (M-10168, CHa, H, F, HOOCCH2CH2CH2CH2, CF3), (M-10169, CHa, H, F, HOOCCH2CH2CH2CH2, Br), (M-10170, CHa, H, F, HOOCCH2CH2CH2CH2, CH3), (M-10171, CH3, H, F, (Me)2NCOCH2CH2CH2CH2, Η), (M-10172, CH3, H，F, (Me)2NCOCH2CH2CH2CH2, Cl), (M-10173, CH3, H, F, (Me)2NCOCH2CH2CH2CH2, F), (M-10174, CH3, H, F, (Me)2NCOCH2CH2CH2CH2, CF3), (M-10175, CH3, H, F, (Me)2NCOCH2CH2CH2CH2, Br), (M-10176, CH3, H, F, (Me)2NCOCH2CH2CH2CH2, CH3), (M-10177, CH3, H, F, (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-10178, CH3, H, F, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-10179, CH3, H, F, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-10180, CH3, H, F, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-10181, CH3, H, F, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-10182, CH3, H, F, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-10183, CH3, H, F, MeOCH2, Η), (M-10184, CHa, H, F, MeOCH2, Cl), (M-10185, CH3, H, F, MeOCH2, F), (M-10186, CH3, H, F, MeOCH2, CF3), (M-10187, CH3, H, F, MeOCH2, Br)，（M-10188, CH3, H，F, MeOCH2, CH3), (M-10189, CH3, H, F, EtOCH2, Η), (M-10190, CH3, H，F， EtOCH2, Cl), (M-10191, CH3, H, F, EtOCH2, F)，（M-10192, CH3, H, F, EtOCH2, CF3), (M-10193, CH3, H, F, EtOCH2, Br), (M-10194, CH3, H, F, EtOCIh，CH3)， (M-10195, CH3, H, F, EtOCH2CH2, Η), (M-10196, CH3, H, F，EtOCH2CH2, Cl)， (M-10197, CH3, H, F, EtOCH2CH2, F), (M-10198, CH3, H，F，EtOCH2CH2, CF3)， 264 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -------------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（如） (M-10199, CH3, H, F, EtOCH2CH2, Br), (M-10200, CH3, H, F, EtOCH2CH2, CH3)， (M-10201, CH3, H, F, MeOCH2CH2〇CH2CH2, H)，（M-10202, CH3, H，F， MeOCH2CH2〇CH2CH2, Cl), (M-10203, CH3, H, F, MeOCH2CH2〇CH2CH2, F), (M-10204, CHa, H, F, MeOCH2CH2〇CH2CH2, CFa), (M-10205, CHn, Π, F, MeOCH2CH2〇CH2CH2, Br), (M-10206, CH3, H, F, MeOCH2CH2〇CIl2CH2, Cih), (M-10207, CH3, H, F，MeOCH2CH2, Η), (M-10208, CHs, H, F，MeOCIhCIh，Cl)， (M-10209, CH3, H, F, MeOCH2CH2, F), (M-10210, CH3, H, F, MeOCH2CH2, CF3)， (M-10211, CH3, H, F, MeOCH2CH2, Br), (M-10212, CHs, H, F, MeOCH2CH2, CH3), (M-10213, CHs, H, F, HOCH2, Η), (M-10214, CHa, H, F, HOCH2, Cl), (M-10215, CH3, H, F, HOCH2, F), (M-10216, CH3, H, F, HOCH2, CFa), (M-10217, CH3, H, F, HOCH2, Br), (M-10218, CHa, H, F, HOCH2, CHa), (M-10219, CHs, H, F, HOCH2CH2, Η), (M-10220, CHa, H, F, HOCH2CH2, Cl), (M-10221, CHa, H, F, HOCH2CH2, F), (M-10222, CHa, H, F, HOCH2CH2, CFa), (M-10223, CHa, H, F, HOCH2CH2, Br), (M-10224, CHa, H, F, HOCH2CH2, CH3), (M-10225, CHs, H, F, HOCH2CH2CH2, Η), (M-10226, CHa, H, F, HOCH2CH2CH2, Cl), (M-10227, CHa, H, F, HOCH2CH2CH2, F), (M-10228, CHa, H, F, HOCH2CH2CH2, CFa), (M-10229, CHs, H, F, HOCH2CH2CH2, Br), (M-10230, CHa, H, F, HOCH2CH2CH2, CH3), (M-10231, CHs, H, F, HOCH2CH2CH2CH2, Η), (M-10232, CH3, H, F, HOCH2CH2CH2CH2, Cl), (M-10233, CH3, H, F, HOGH2CH2CH2CH2, F), (M-10234, CHs, H, F, HOCH2CH2CH2CH2, CFa), (M-10235, CHa, H, F, HOCH2CH2CH2CH2, Br), (M-10236, CH3, H, F, HOCH2CH2CH2CH2, CH3), (M-10237, CHa, H, F, HOCH2CH2CH2CH2CH2, Η), (M-10238, CHs, H, F, HOCH2CH2CH2CH2CH2, Cl), (M-10239, CHa, H, F, HOCH2CH2CH2CH2CH2, F), (M-10240, CH3, H, F, HOCH2CH2CH2CH2CH2, CF3), (M-10241, CH3, H, F, HOCH2CH2CH2CH2CH2, Br), (M-10242, CHa, H, F, HOCH2CH2CH2CH2CH2, CHs), (M-10243, CHs, H, F, HOCH2CH2OCH2CH2, Η), (M-10244, CHa, H, F, ____265 __ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ---- — — — — — — I— (請先閱讀背面之注意事項再填寫本頁)
I I I I 訂---------着· 12祕3 9 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（如） . HOCH2CH2OCH2CH2, Cl), (M-10245, CHs, H, F, HOCH2CH2OCH2CH2, F), (M-10246, CHs, H, F, HOCH2CH2OCH2CH2, CFa), (M-10247, CHa, H, F, HOCH2CH2OCH2CH2, Br), (M-10248, CHa, H, F, HOCH2CH2OCH2CH2, CH3), (M-10249, CH3, H, F, (Me)2N, Η), (M-10260, CHa, H, F, (Me)2N, Cl), (M-10251. CHa, H, F, (Me)2N, F), (M-10252, CHa, H, F, (Me)2N, CFs), (M-10253, CHs, Hf F, (Me)2N, Br), (M-10254, CH3, H, F, (Me)2N, CHa), (M-10255, CHa, H, F, 哌啶-4 -基甲基:，Η), (M-10256, CH3, H, F,哌啶-4 -基甲基，Cl), (M-10257, CH3, H, F,派 u定-4-基甲基，F), (M-10258, CH3, H, F, 哌啶-4 -基甲基，〇尸3),(1^-10259,(^3，11彳，哌啶-4-基甲基，1^), (M-10260, CH3, H, F,脈 u定-4-基甲基 1, CH3)，（M-10261，CH3, H，F, 環己基甲棊，Η), (Μ·1〇262, CH3, H, F,環己 _ 甲基，Cl), (M-l〇263， CH3, H, F,環己基甲基，F), (M-10264, CH3, H, F,環己基甲基，CF3)， (M-10265, CHa, H, F,環己基甲基,Br), (M-10266, CH3, H, F, 環己基甲基，CH3), (M-l〇267, CH3, H, Cl, Η, Η), (Μ·1〇268, CHs，H, Cl, H,
Cl), (M-10269, CH3, H, Cl, H, F), (M-10270, CH3, H, Cl, H, CF3>, (M-10271, CH3, H, Cl, H, Br), (M-10272, CH3, H, Cl, H, CH3), (M-10273, CH3, H, Cl, F, H)， (M-10274, CH3, H, Cl, F, Cl), (M-10275, CH3, H, Cl, F, F)，（M-10276, CH3, H，Cl， F, CF3), (M-10277, CH3, H, Cl, F, Br), (M-10278, CH3, H, Cl, F, CH3), (M-10279, CH3, H, Cl, Cl, Η), (M-10280, CHa, H, Cl, Cl, Cl), (M-10281, CH3, H, Cl, Cl, F), (M-10282, CH3, H, Cl, Cl, CF3), (M-10283, CH3, H, Cl, Cl, Br), (M-10284, CH3, H, Cl, Cl, CH3), (M-10285, CH3, H, Cl, CH3, Η), (M-10286, CH3, H，Cl, CH3, Cl)， (M-10287, CH3, H，Cl, CH3, F), (M-10288, CH3, H，Cl，CH3, CF3), (M-10289, CH3, H, Cl, CH3, Br), (Μ·10290, CH3, H, Cl, CH3, CH3), (M-10291, CH3, H, Cl，Et, H)， (M-10292, CHa, H, Cl, Et, Cl), (M-10293, CH3, H, Cl, Et, F), (M-10294, CH3, H,
Cl, Et, CFa), (M-10295, CHa, H, Cl, Et, Br), (M-10296, CHa, H, Cl, Et, CHs), (M-10297, CHs, H, Cl, n-Pr, Η), (M-10298, CH3, H, Cl, n-Pr, Cl), (M-10299, CHa, 266 尺度適用中國國家標準（CNS)A4規格（210 x 297公釐了" ---- (請先閱讀背面之注意事項再填寫本頁) ^4 * ·_1 1 言 經濟部智慧財產局員工消費合作社印製 1284639 A7 -----B7_____ 五、發明說明（4jr) H, Cl, π-Pr, F), (M-10300, CHa, H, Cl, n-Pr, CF3), (M-10301, CHs, H, Cl, n-Pr, Br), (M-10302, CH3, H, Cl, n-Pr, CHa), (M-10303, CH3, H, Cl, c-Pr, Η), (M-10304, CH3, H, Cl, c-Pr, Cl), (M-10305, CH3, H, Cl, c-Pr, F), (M-10306, CH3, H, Cl, c-Pr, CFs), (M-10307, CHa, H, Cl, c-Prf Br)t (M-10308, CAL·, H. Cl. c-Pr. CHa), (M-10309, CH3, H, Cl, i-Pr, Η), (M-10310, CH3, H, Cl, i-Pr, Cl), (M-10311, CH3, H, Cl, i-Pr, F), (M-10312, CH3, H, Cl, i-Pr, CF3), (M-10313, CH3, H, Cl, i-Pr, Br), (M-10314, CH3, H, Cl, i-Pr, CHa), (M-10315, CHa, H, Cl, n-Bu, Η), (M-10316, CH3, H, Cl, n-Bu, Cl), (M-10317, CHa, H, Cl, n-Bu, F), (M-10318, CHa, H, Cl, n-Bu, CF3), (M-10319, CHs, H, Cl, n-Bu, Br), (M-10320, CHa, H, Cl, n-Bu, CHs), (M-10321, CH3, H, Cl, i-Bu, Η), (M-10322, CH3, H, Cl, i-Bu, Cl), (M-10323, CH3, H, Cl, i-Bu，F), (M-10324, CH3, H, Cl, i-Bu, CF3), (M-10325, CH3, H, Cl, i-Bu, Br), (M-10326, CH3, H, Cl, i-Bu, CH3), (M-10327, CH3, H, Cl, sec-Bu, Η), (M· 10328, CHs, H, Cl, sec-Bu, Cl), (M-10329, CHa, H, Cl, sec-Bu, F), (M-10330, CHa, H, Cl, sec-Bu, CF3), (M-10331, CH3, H, Cl, sec-Bu, Br), (M-10332, CH3, H, Cl， sec-Bu, CHa), (M-10333, CHa, H, Cl, n-Pen, Η), (M-10334, CHa, H, Cl, n-Pen, Cl), (M-10335, CHa, H, Cl, n-Pen, F), (M-10336, CHa, H, Cl, n-Pen, CF3), (M-10337, CHs, H, Cl, n-Pen, Br), (M-10338, CHa, H, Cl, n-Pen, CHa), (M-10339, CH3, H, Cl, c-Pen, Η), (M-10340, CH3, H, Cl, c-Pen, Cl), (M-10341, CH3, H, Cl， c-Pen, F), (M-10342, CHs, H, Cl, c-Pen, CF3), (M-10343, CHa, H, Cl, c-Pen, Br), (M-10344, CHs, H, Cl, c-Pen, CHs), (M-10345, CH3, H, Cl, n-Hex, Η), (M-10346, CH3, H, Cl, n-Hex, Cl), (M-10347, CHa, H, Cl, n-Hex, F), (M-10348, CHa, H, Cl, n-Hex, CFa), (M-10349, CH3, H, Cl, n-Hex, Br), (M-10350, CHa, H, Cl, n-Hex, CH3), (M-10351, CH3, H, Cl, c_Hex, Η), (M-10352, CH3, H, Cl, c-Hex，Cl), (M-10353, CH3, H, Cl, c-Hex, F), (M-10354, CH3, H, Cl, c-Hex, CF3), (M-10355, CH3, H, Cl, c-Hex, Br), (M-10356, CH3, H, Cl, c-Hex, CH3), (M-10357, CH3, H，Cl, OH， Η), (M-10358, CH3, H, Cl, OH, Cl), (M-10359, CH3, H, Cl，OH，F)，（M-10360， ___267_ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ， -------------------^--------- (請先閱讀背面之注意事項再填寫本頁) A7 1284639 B7_______ 五、發明說明（>从） CHs, H, Cl, OH, CFs), (M-10361, CHa, H, Cl, OH, Br), (M-10362, CH3, H, Cl, OH, CH3), (M-10363, CH3, H, Cl, EtO, Η), (M-10364, CH3, H, Cl, EtO, Cl), (M-10365, CH3, H, Cl, EtO, F), (M-10366, CH3, H, Cl, EtO, CF3), (M-10367, CH3, H, Cl, EtO, Br), (M-10368, CHa, H, Cl, EtO, CHa), (M-10369, CHa, H, Cl, n-PrO, H), (M-10370, CHs, H, Cl, n-PrO, Cl), (M-10371, CHs, H, Cl, n-PrO, F), (M-10372, CH3, H, Cl, n-PrO, CF3), (M-10373, CH3, H, Cl, n-PrO, Br), (M-10374, CH3, H， Cl, n-PrO, CH3), (M-10375, CH3, H, Cl, PhO, Η), (M-10376, CH3, H, Cl, PhO, Cl)， (M-10377, CH3, H, Cl, PhO, F)，（M-10378, CH3, H, Cl, PhO, CF3), (M-10379， CH3, H, Cl, PhO, Br), (M-10380, CH3, H, Cl, PhO, CHs), (M-10381，CH3, H，Cl， BnO, Η), (M-10382, CH3, H，Cl, BnO, Cl), (M-10383, CH3, H, Cl, BnO, F)，（M-10384, CH3, H, Cl, BnO, CF3), (M-10385, CH3, H, Cl, BnO, Br), (M-10386, CHs， H, Cl, BnO, CH3), (M-10387, CH3, H, Cl, PhCH2CH2〇, Η), (M-10388, CH3, H，Cl， PhCH2CH2〇, Cl), (M-10389, CHa, H, Cl, PhCH2CH2〇, F), (M-10390, CHa, H, Cl, PhCH2CH2〇, CF3), (M-10391, CH3, H, Cl, PhCH2CH2〇, Br), (M-10392, CH3, H, Cl, PhCH2CH2〇, CH3), (M-10393, CH3, H, Cl, CF3〇, Η), (M-10394, CH3, H, Cl， CF3〇, Cl), (M-10395, CH3, H, Cl, CF3〇, F), (M-10396, CH3, H，Cl, CF3〇, CF3)， (M-10397, CH3, H, Cl, CF3〇, Br), (M-10398, CH3, H, Cl, CF3〇, CH3), (M-10399, CH3, H, Cl, Ph, Η), (M-10400, CH3, H, Cl, Ph, Cl), (M-10401, CH3, H，Cl, Ph，F)， (M-10402, CH3, H, Cl, Ph, CF3), (M-10403, CH3, H, Cl, Ph, Br), (M-10404, CH3, H, Cl, Ph, CHa), (M-10405, CHa, H, Cl, 4-F-Ph, Η), (M-10406, CH3> H, Cl, 4-F-Ph, Cl), (M-10407, CH3, H, Cl, 4-F-Ph, F), (M-10408, CH3, H，Cl, 4-F-Ph, CF3), (M-10409, CHa, H, Cl, 4-F-Ph, Br), (M-10410, CHs, H, Cl, 4-F-Ph, CHa), (M-10411, CHa, H, Cl, 4-CFa-Ph, Η), (M-10412, CHs, H, Cl, 4-CF3-Ph, Cl), (M-10413, CHa, H, Cl, 4-CF3-Ph, F), (M-10414, CHa, H, Cl, 4-CF3-Ph, CFa), (M-10415, CH3, H, Cl, 4-CF3-Ph, Br), (M-10416, CHa, H, Cl, 4-CF3-Ph, CHa), (M-10417, CH3, H, Cl, 4-(Me)2N-Ph, Η), (M-10418, CH3, H, Cl, 4-(Me)2N-Ph，Cl)， 268 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ---------------- (請先閱讀背面之注意事項再填寫本頁) ϋ ϋ I n tr--------- 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1284639 A7 ___ B7_________ 五、發明說明（47 ) (Μ·1〇419, CH3, H, Cl, 4-(Me)2N-Pli, F), (M-10420, CH3, H, Cl, 4-(Me)2N-Ph， CFa), (M-10421, CHs, H, Cl, 4-(Me)2N.Ph, Br), (M-10422, CHa, H, Cl, 4-(Me)2N-Ph, CH3), (M-10423, CHs, H, Cl, 4-OH-Ph, Η), (M-10424, CHa, H, Cl, 4-OH-Ph, Cl), (M-10425, CHa, H, Cl, 4-OH.Ph, F), (M-10426, Clh, H, CK 4-〇H-Ph, CFa), (M-10427, CHa, H, Cl, 4-OH-Ph, Br), (M-10428, CHs, H, Cl, 4· 〇H-Ph, CH3), (M-10429, CH3, H, Cl, 3,4-di-F-Ph, Η), (M-10430, CH3, H，Cl, 3.4- di-F-Ph, Cl), (M-10431, CH3, H, Cl, 3,4-di-F-Ph, F)，（M-10432, CH3, H, Cl， 3.4- di-F-Ph, CF3), (M-10433, CH3, H, Cl, 3,4-di-F-Ph, Br), (M-10434, CH3, H，Cl， 3.4- di-F-Ph, CH3), (M-10435, CH3, H, Cl, 4-COOH-Ph, Η), (M-10436, CH3, H，Cl， 4-COOH-Ph, Cl), (M-10437, CH3, H, Cl, 4-COOH-Ph, F), (M-10438, CH3, H，Cl， 4-COOH-Ph, CF3), (M-10439, CH3, H, Cl, 4-COOH-Ph, Br), (M-10440, CH3, H， Cl，4-COOH-Ph, CH3), (M-10441, CH3, H, Cl, Bn, Η), (M-10442, CH3, H，Cl，Bn， Cl), (M-10443, CH3, H, Cl, Bn, F), (M-10444, CH3, H, Cl, Bn, CF3), (M-10445， CH3, H, Cl, Bn, Br), (M-10446, CHs, H, Cl, Bn, CHa), (M-10447, CHa, H, Cl, 4-F-Bn，Η), (M-10448, CH3, H, Cl, 4-F-Bn, Cl), (M-10449, CH3, H, Cl, 4-F-Bn，F), (M-10450, CHa, H, Cl, 4-F-Bn, CFs), (M-10451, CH3, H, Cl, 4-F-Bn, Br), (M-10452, CH3, H, Cl, 4-F-Bn, CH3), (M-10453, CH3, H, Cl, 2-Py, Η), (M-10454, CH3, H, Cl, 2-Py, Cl), (M-10455, CH3, H, Cl, 2-Py, F), (M-10456, CH3, H, Cl， 2-Py, CF3), (M-10457, CH3, H, Cl, 2-Py, Br), (M-10458, CH3, H, Cl, 2-Py, CH3)， (M-10459, CHa, H, Cl, 3-Py, Η), (M-10460, CHs, H, Cl, 3-Py, Cl), (M-10461, CHs, H, Cl, 3-Py, F), (M-10462, CH3, H, Cl, 3-Py, CF3), (M-10463, CH3, H，Cl, 3-Py, Br), (M-10464, CH3, H, Cl, 3-Py, CH3), (M-10465, CHs, H, Cl, 4-Py, Η), (M-10466, CH3, H, Cl, 4-Py, Cl), (M-10467, CH3, H, Cl, 4-Py, F), (M-10468, CH3, H, Cl, 4-Py, CF3), (M-10469, CH3, H, Cl，4-Py, Br), (M-10470, CH3, H, Cl, 4-Py， CHa), (M-10471, CHs, H, Cl, 2-Th, Η), (M-10472, CHa, H, Cl, 2-Th, Cl), (M-10473, CH3, H, Cl, 2-Th, F), (M-10474, CH3, H, Cl, 2-Th, CF3), (M-10475, CH3, 一 _269__ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） __f_________ ----------- (請先閱讀背面之注意事項再填寫本頁) •I ^1 ϋ 訂--- A7 1284639 _B7___ 五、發明說明（外彳） H, Cl, 2-Th, Br), (M-10476, CHs, H, Cl, 2-Th, CHa), (M-10477, CHs, H, Cl, 3-Th, Η), (M-10478, CHa, H, Cl, 3-Th, Cl), (M-10479, CHa, H, Cl, 3-Th, F), (M-10480, CH3, H, Cl, 3-Th, CF3), (M-10481, CH3, H, Cl, 3-Th, Br), (M-10482, CH3, H, Cl, 3-Th, CH3>, (M-10483, CH3, H, Cl,吡唑-2_基，H), (M-10484, CH·% H, Cl, 吡唑-2-基，Gl), (Μ·1048δ, CH3, H, Cl,吡唑-2-基「F), (M-10486, CHa，H, Cl，吡唑-2-基，CF3), (M-10487, CH3, H, Cl,吡唑-2-基，Br), (M-10488， CH3, H, Cl,吡唑-2-基，CH3), (M-10489, CH3, H, Cl,吡唑-3-基，H)，（M-10490, CH3, H, Cl,吡唑-3-基，Cl), (M-10491, CH3, H, Cl,吡嗤·3-基，F)， (M-10492, CH3, H, Cl,吡唑-3·基，CF3), (M-1CM93, CH3, H，Cl,毗唑-3-基， Br), (M-10494, CH3, H, Cl,吡唑-3-基CH3), (M-10495, CH3, H, Cl, 嘧啶-2-基 rl, Η), (M-10496, CH3, H, Cl,嘧啶-2-基丨,Cl), (M-10497, CH3, H, Cl，:嘧啶-2-基Λ F), (M-10498, CH3, H, Cl,嘧啶-2-基，CF3)，（M-10499, CH3, H, Cl,嘧啶-2 -基，Br), (M-10500, CH3, H，Cl,嘧聢-2 -基，CH3), (M-10501, CH3, H, Cl,嘧啶-2-基，H>, (M-10502, CH3, H, Cl,嘧啶-4-基，Cl), (M-10503, CH3, H, Cl,嘧啶-4-棊，F), (M-10504, CH3, H, Cl， 嘧啶-4-基，CjF3), (M-10505, CH3, H, Cl,嘧啶-4-基，Br)，（M-10506, CH3, H, Cl,嘧啶-4-棊，CH3), (M-10507, CH3, H, Cl,嘧啶-5-基1,11),(1^· 10508, CH3, H, Cl,嘧啶-5-基，Cl), (M-10509, CH3, H, Cl, pyrimidin-5-yl， F), (M-10510, CH3, H, Cl,嘧啶-5-基，CF3), (M-10511, CH3, H, Cl, 嘧啶-5-基，Br), (M-10512, CH3, H, Cl,:嘧啶-5·基，CH3)，（M-10513， CHs, H, Cl, HOOCCH2CH2CH2, Η), (M-10514, CH3, H, Cl, HOOCCH2CH2CH2, Cl), (M-10515, CHa, H, Cl, HOOCCH2CH2CH2, F), (M-10516, CH3, H, Cl, HOOCCH2CH2CH2, CF3), (M-10517, CH3, H, Cl, HOOCCH2CH2CH2, Br), (M-10518, CHa, H, Cl, HOOCCH2CH2CH2, CHa), (M-10519, CHa, H, Cl, HOOCCH2CH2CH2CH2, Η), (M-10520, CHa, H, Cl, HOOCCH2CH2CH2GH2, Cl), (M-10521, CH3, H, Cl, HOOCCH2CH2CH2CH2, F), (M-10522, CH3, H, Cl, 270 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） " (請先閱讀背面之注意事項再填寫本頁) 裝--------訂---------· 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員H消費合作社印製 1284639 A7 _B7____ 五、發明說明（>巧） HOOCCH2CH2CH2CH2, CFs), (M-10523, CHa, H, Cl, HOOCCH2CH2CH2CH2,
Br), (M-10524, CH3, H, Cl, HOOCCH2CH2CH2CH2, CHs), (M-10525, CHa, H, Cl, (Me)2NCOCH2CH2CH2CH2, Η), (M-10526, CH3, H, Cl, (Me)2NCOCH2CH2CH2CH2, Cl), (M-10527, CHa, H, Cl, (Me)2NCOCH2CH2CH2CH2, F), (M-10528, CH3, H, Cl, (Me)2NCOCH2CH2CH2CH2, CFa), (M-10529, CH3, H, Cl, (Me)2NCOCH2CH2CH2CH2, Br), (M-10530, CH3, H, Cl, (Me)2NCOCH2CH2CH2CH2, CH3), (M-10531, CH3, H, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-10532, CH3, H, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-10533, CH3, H, Cl, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-10534, CH3, H, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-10535, CH3, H, Cl， (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-10536, CH3, H, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-10537, CH3, H, Cl, MeOCH2, H)，（M· 10538, GHa, H, Cl, MeOCH2, Cl), (M-10539, CHa, H, Cl, MeOCH2, F), (M-10540, CH3, H, Cl, MeOCH2, CF3), (M-10541, CH3, H, Cl, MeOCH2, Br), (M-10542, CH3, H, Cl, MeOCH2, CHs), (M-10543, CH3, H, Cl, EtOCH2, Η), (M-10544, CH3, H, Cl, EtOCH2, Cl), (M-10545, CH3, H, Cl, EtOCH2, F), (M-10546, CH3, H, Cl, EtOCH2, CFs), (M-10547, CHs, H, Cl, EtOCH2, Br), (M-10548, CHa, H, Cl, EtOCH2, CH3), (M-10549, CH3, H, Cl, EtOCH2CH2, Η), (M-10550, CH3, H, Cl, EtOCH2CH2, Cl)， (M-10551, CH3, H, Cl, EtOCH2CH2, F), (M-10552, CHs, H, Cl, EtOCH2CH2, CFs), (M-10553, CHs, H, Cl, EtOCH2CH2, Br), (M-10554, CHa, H, Cl, EtOCH2CH2, CH3), (M-10555, CH3, H, Cl, MeOCH2CH2〇CH2CH2, Η), (M-10556, CHs, H, Cl, MeOCH2CH2〇CH2CH2, Cl), (M-10557, CH3, H, Cl， MeOCH2CH2〇CH2CH2, F)，（M-10558, CH3, H, Cl, MeOCH2CH2〇CH2CH2, CF3)， (M-10559, CH3, H, Cl, MeOCH2CH2〇CH2CH2, Br), (M-10560, CH3, H, Cl， 271 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂--------- 經濟部智慧財產局員工消費合作社印製 1284639 A7 , _B7_ ；_ 五、發明說明卜V)
MeOCH2CH2〇CH2CH2, CH3), (M-10561, CH3, H, Cl, MeOCH2CH2, Η)，（Μ-10562, CH3, H, Cl, MeOCH2CH2, Cl), (M-10563, CH3, H, Cl, MeOCH2CH2, F), (M-10564, CHa, H, Cl, MeOCH2CH2, CFa), (M-10565, CH3, H, Cl, MeOCH2CH2, Br), (M-10566, CHa, H, Cl, MeOCH2CH2, CHa), (M-10567, CHn, H, Cl, HOCITa, Η), (M-10568, CH3, H, Cl, HOCH2, Cl), (M-10569, CH3, H, Cl, HOCH2, F), (M· 10570, CHa, H, Cl, HOCH2, CFs), (M-10571, CHa, H, Cl, HOCH2, Br), (M-10572, CHa, H, Cl, HOCH2, CHs), (M-10573, CHs, H, Cl, HOCH2CH2, Η), (M-10574, CHa, H, Cl, HOCH2CH2, Cl), (M-10575, CHa, H, Cl, HOCH2CH2, F), (M-10576, CHs, H, Cl, HOCH2CH2, CFa), (M-10577, CH3, H, Cl, HOCH2CH2, Br), (M-10578, CH3, H, Cl, HOCH2CH2, CHs), (M-10579, CHa, H, Cl, HOCH2CH2CH2, Η), (M-10580, CHa, H, Cl, HOCH2CH2CH2, Cl), (M-10581, CHs, H, Cl, HOCH2CH2CH2, F), (M-10582, CHa, H, Cl, HOCH2CH2CH2, CFa), (M-10583, CH3, H, Cl. HOCH2CH2CH2, Br), (M-10584, CHa, H, Cl, HOCH2CH2CH2, CH3), (M-10585, CHs, H, Cl, HOCH2CH2CH2CH2, Η), (M-10586, CHs, H, Cl, HOCH2CH2CH2CH2, Cl), (M-10587, CH3, H, Cl, HOCH2CH2CH2CH2, F), (M-10588, CHa, H, Cl, HOCH2CH2CH2CH2, CFs), (M-10589, CH3, H, Cl, HOCH2CH2CH2CH2, Br), (M-10590, CHa, H, Cl, HOCH2CH2CH2CH2, CHa), (M-10591, CHs, H, Cl, HOCH2CH2CH2CH2CH2, Η), (M-10592, CHs, H, Cl, HOCH2CH2CH2CH2CH2,
Cl), (M-10593, CHa, H, Cl, HOCH2CH2CH2CH2CH2, F), (M-10594, CH3, H, Cl, HOCH2CH2CH2CH2CH2, CF3), (M-10595, CHs, H, Cl, HOCH2CH2CH2CH2CH2, Br), (M-10596, CHa, H, Cl, HOCH2CH2CH2CH2CH2, CHa), (M-10597, CHs, H, Cl, HOCH2CH2OCH2CH2, H), (M-10598, CHa, H, Cl, HOCH2CH2OCH2CH2, Cl), (M-10599, CHs, H, Cl, HOCH2CH2OCH2CH2, F), (M-10600, CH3, H, Cl, HOCH2CH2OCH2CH2, CFa), (M-10601, CHa, H, Cl, HOCH2CH2OCH2CH2, Br)t (M-10602, CH3, H, Cl, HOCH2CH2OCH2CH2, CH3), (Μ·10603, CH3, H, Cl, (Me)2N, Η), (M-10604, CH3, H, Cl, (Me)2N, Cl), (M-10605, CHa, H, Cl, (Me)2N, 272 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） (請先閱讀背面之注意事項再填寫本頁)
經濟部智慧財產局員工消費合作社印製 1284639 A7 ____B7_ ；_ — 五、發明說明卜W) F), (M-10606, CHa, H, Cl, (Me)2N, CFs), (M-10607, CHa, H, Cl, (Me)2N, Br), (M-10608, CH3, H, Cl, (Me)2N, CH3), (M-10609, CH3, H, Cl,哌啶-4-基 甲基, Η), (M-10610, CH3, H, Cl,哌啶-4-基甲基，Cl), (M-10611, CH3, Η, Cl,哌啶-4-基甲基.,F), (M-10612, CH3, H, Cl,哌啶-4-基甲棊， CF3)，（M-10613, CH3, H, Cl,哌啶-4 -基甲碁，Br), (M-10614, CH3, H, Cl, 哌啶-4-基甲基，CH3), (M-10615, CH3, H, Cl, c.環己基甲基，HMM· 10616, CH3, H, Cl,環己基甲基，Cl), (M-10617, CH3, H, Cl, 環己基甲基:,F), (M-10618, CH3, H, Cl,環己基甲基，CF3), (M-10619, CH3, H, Cl,環己基甲基,Br), (M-10620, CH3, H, Cl,環己基甲基， CH3), (M-10621, CH3, F, Η, Η, Η), (M-10622, CH3, F, Η, H, Cl)，（M-10623, CH3, F,H,H,F),(M-10624,CH3,F,H,H,CF3),(M-10625,CH3,F,H，H,Br)，（M· 10626, CH3, F, H，H, CH3), (M-10627, CH3, F, H, F, Η), (Μ·10628, CH3, F, H, F、 Cl), (M-10629, CH3, F, H, F, F), (M-10630, CH3, F, H, F, CF3), (M-10631，CH3, F, H, F, Br), (M-10632, CH3, F, H, F, CH3), (M-10633, CH3, F, H, Cl, H)，（M-10634, CH3, F, H, Cl, Cl), (M-10635, CH3, F, H, Cl, F), (M-10636, CH3, F, H, Cl, CFs)， (M-10637, CH3, F, H, Cl, Br), (M-10638, CH3, F, H, Cl, CH3), (M-10639, CH3, F， H，CH3, Η), (M-10640, CH3, F, H, CH3, Cl), (M-10641, CH3, F, H, CH3, F)，（M· 10642, CH3, F, H, CH3, CF3), (M-10643, CH3, F, H, CH3, B〇, (M-10644, CH3, F, H, CH3, CHs), (M-10645, CHs, F, H, Et, Η), (M-10646, CH3, F, H, Et, Cl), (M-10647, CH3, F, H, Et, F), (M-10648, CH3, F, H, Et, CF3), (M-10649, CH3, F, H，Et， Br), (M-10650, CH3, F, H, Et, CH3), (M-10651, CH3, F, H, n-Pr, H)，（M-10652, CH3, F, H, n-Pr, Cl), (M-10653, CHs, F, H, n-Pr, F), (M-10654, CHa，F, H, n-Pr， CFa), (M-10655, CHa, F, H, n-Pr, Br), (M-10656, CHa, F, H, n-Pr, CHa), (M-10657, CHa, F, H, c-Pr, Η), (M-10658, CH3, F, H, c-Pr, Cl), (M-10659, CH3, F, H, c-Pr, F), (M-10660, CHa, F, H, c-Pr, CFa), (M-10661, CHs, F, H, c-Pr, Br), (M-10662, CH3, F, H, c-Pr, CHs), (M-10663, CHa, F, H, i-Pr, Η), (M-10664, CHa, F, 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） I.---U.--------------^--------- (請先閱讀背面之注意事項再填寫本頁) _ 273 __ 經濟部智慧財產局員工消費合作社印製 1284639 A7 __B7________ 五、發明說明 H, i-Pr, Cl), (M-10665, CHs, F, H, i-Pr, F), (M-10666, CHa, F, H, i-Pr, CFa), (M-10667, CH3, F, H, i-Pr, Br), (M-10668, CH3, F, H, i-Pr, CH3)，（M-10669, CH3, F, H, n-Bu, Η), (M-10670, CHs, F, H, n-Bu, Cl), (M-10671, CH3, F, H, n-Bu, F), (M-10672, CHa, F, H, n-Bu, CFa), (M-10673, CHa, F, H, n-Bu, Br), (M-10674. CHa, F, H, n-Bu, CHa), (M-10675, CHa, F, H, i-Bu, Η), (M-10676, CHa, F, H, i-Bu, Cl), (M-10677, CHa, F, H, i-Bu, F), (M-10678, CHa, F, H, i-Bu, CFa), (M-10679, CHa, F, H, i-Bu, Br), (M-10680, CHs, F, H, i-Bu, CH3), (M-10681, CHa, F, H, sec-Bu, Η), (M-10682, CHs, F, H, sec-Bu, Cl), (M-10683, CHa, F, H, sec-Bu, F), (M-10684, CHs, F, H, sec-Bu, CF3), (M-10685, CHs, F, H, sec-Bu, Br), (M-10686, CHa, F, H, sec-Bu, CHs), (M-10687, CHs, F, H, n-Pen, Η), (M-10688, CHa, F, H, n-Pen, Cl), (M-10689, CH3, F, H, n-Pen, F), (M-10690, CH3, F, H, n-Pen, CFa), (M-10691, CHa, F, H, n-Pen, Br), (M-10692, CHs, F, H, n-Pen, CHa), (M-10693, CHa, F, H, c-Pen, Η), (M-10694, CHs, F, H, c-Pen, Cl), (M-10695, CHa, F, H, c-Pen, F), (M-10696, CH3, F, H, c-Pen, CF3), (M-10697, CH3, F, H, c-Pen, Br)， (M-10698, CH3, F, H, c-Pen, CH3), (M-10699, CHa, F, H, n-Hex, Η), (M-10700, CH3, F, H, n-Hex, Cl), (M-10701, CH3, F, H, n-Hex, F), (M-10702, CH3, F，H， n-Hex，CF3), (M-10703, CH3, F, H, n-Hex, Br), (M-10704, CH3, F, H, n-Hex, CHs), (M-10705, CHs, F, H, c-Hex, Η), (M-10706, CHa, F, H, c-Hex, Cl), (M-10707, CH3, F, H, c-Hex, F), (M-10708, CH3, F, H, c-Hex, CF3), (M-10709, CH3, F，H，c-Hex, Br), (M-10710, CH3, F, H，c-Hex, CH3), (M-10711, CH3, F, H，OH, Η), (M-10712, CH3, F, H, OH, Cl), (M-10713, CH3, F, H, OH, F), (M-10714, CH3, F, H，OH, CF3), (M-10715, CH3, F, H, OH, Br), (M-10716, CH3, F, H, OH, CH3)， (M-10717, CH3, F, H, EtO, Η), (M-10718, CH3, F, H，EtO, Cl), (M-10719, CH3, F， H, EtO, F), (M-10720, CH3, F, H, EtO, CF3), (M-10721，CH3, F, H, EtO, Br)， (M-10722, CH3, F, H, EtO, CH3), (M-10723, CH3, F，H，n-PrO, Η), (M-10724, CHa, F, H, n-PrO, Cl), (M-10725, CHs, F, H, n-PrO, F), (M-10726, CHa, F, H, __274__ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ii——卜------ (請先閱讀背面之注意事項再填寫本頁) 訂--------- / 1284639 A7 B7 五、發明說明卜π) n-PrO, CFa), (M-10727, CH3, F, H, n-PrO, Br), (M-10728, CHa, F, H, n-PrO, CH3), (M-10729, CH3, F, H, PhO, Η), (M-10730, CH3, F, H, PhO, Cl), (M-10731， CH3, F, H, PhO, F), (M-10732, CH3, F, H, PhO, CFa), (M-10733, CHa, F, H, PhO, Br), (M-10734, CHa, F, H, PhO, CHn), (M-10735, CHa, F, Η, ΠηΟ, Η), (M-107ae, CHa, F, H, BnO, Cl), (M-10737, CH3, F, H, BnO, F), (M-10738, CH3, F, H, BnO, CFs), (M-10739, CHa, F, H, BnO, Br), (M-10740, CHs, F, H, BnO, CH3), (M-10741, CHa, F, H, PhCH2CH2〇, Η), (M-10742, CHa, F, H, PhCH2CH2〇, Cl), (M-10743, CH3, F, H, PhCH2CH2〇, F), (M-10744, CH3, F, H, PhCH2CH2〇, CF3), (M-10745, CH3, F, H, PhCH2CH2〇, Br), (M-10746, CH3, F, H, PhCH2CH2〇， CHs), (M-10747, CH3, F, H, CF3〇, Η), (M-10748, CH3, F, H, CF3〇, Cl)，（M· 10749, CH3, F, H, CFsO, F), (M-10750, CHa, F, H, CFsO, CFa), (M-10751, CHa, F, H, CF3〇, Br), (M-10752, CH3, F, H, CF3〇, CH3), (Μ·10753, CH3, F, H, Ph，H), (M-10754, CH3, F, H, Ph, Cl), (M-10755, CH3, F, H, Ph, F), (M-10756, CHb, F, H， Ph, CF3), (M-10757, CHs, F, H, Ph, Br), (M-10758, CHa, F, H, Ph, CHa), (M-10759, CHs, F, H, 4-F-Ph, Η), (M-10760, CHa, F, H, 4-F-Ph, Cl), (M-10761, CH3, F, H, 4-F-Ph, F), (M-10762, CHa, F, H, 4-F-Ph, CFa), (M-10763, CHa, F, H, 4-F-Ph, Br), (M-10764, CH3, F, H, 4-F-Ph, CH3), (M-10765, CH3, F, H，4-CF3-Ph, Η), (M-10766, CHa, F, H, 4-CF3.Ph, Cl), (M-10767, CHa, F, H, 4-CFa-Ph, F), (M-10768, CH3, F, H, 4-CF3-Ph, CF3), (M-10769, CH3, F, H, 4-CF3-Ph, Br), (M-10770, CHa, F, H, 4-CF3-Ph, CH3), (M-10771, CHa, F, H, 4.(Me)2N.Ph, H), (M-10772, CHa, F, H, 4-(Me)2N-Ph, Cl), (M-10773, CHa, F, H, 4-(Me)2N-Ph, F), (M-10774, CH3, F, H, 4-(Me)2N-Ph, CF3), (M-10775, CH3, F, H，4-(Me)2N-Ph, Br), (M-10776, CHa, F, H, 4-(Me)2N-Ph, CH3), (M-10777, CH3, F, H, 4-OH-Ph, Η), (M-10778, CHs, F, H, 4-OH-Ph, Cl), (M-10779, CH3, F, H, 4-OH-Ph, F), (M-10780, CH3, F, H, 4-OH-Ph, CF3), (M-10781, CHs, F, H, 4-OH.Ph, Br), (M-10782, CH3, F, H, 4-OH-Ph, CH3), (M-10783, CH3, F, H, 3,4-di-F-Ph, Η), (M- 275 ______ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂---------考 經濟部智慧財產局員工消費合作社印製 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7
五、發明說明（>舛) I 10784, CHa, F, H, 3,4-di-F-Ph, Cl), (M-10785, CHs, F, H, 3,4-di-F-Ph, F), (M- 10786, CH3, F, H, 3,4-di-F-Ph, CF3), (M-10787, CH3, F, H, 3,4-di-F-Ph, Br), (M-10788, CH3, F, H, 3,4-di-F-Ph, CH3), (M-10789, CH3, F, H, 4-COOH-Ph, H), (M-10790, CH3, P, H, 4.COOII-Ph, Cl), (Μ-107Π1, CII,i, F, II, d-COOH-Ph, F), (M-10792, CH3, F, H, 4-C00H-Ph, CF3), (M-10793, CH3, F, H, 4-COOH-Ph, Br), (M-10794, CHs, F, H, 4-C00H-Ph, CHs), (M-10795, CHa, F, Η, Bn, Η), (M-10796, CH3, F, H, Bn, Cl), (M-10797, CH3, F, H, Bn, F), (M-10798, CH3, F，H, Bn， CF3), (M-10799, CHa, F, H, Bn, Br), (M-10800, CHa, F, H, Bn, CHa), (M-10801, CH3, F, H, 4-F-Bn, Η), (M-10802, CH3, F, H, 4-F-Bn, Cl), (M-108O3, CH3, F, H， 4-F-Bii, F), (M-10804, CH3, F, H, 4-F-Bn, CF3), (M-10805, CH3, F, H, 4-F-Bn， Br),(M-10806,CH3,F,H,4-F-Bn,CH3),(M-10807,CH3,F,H,2-Py,H),(M· 10808, CH3, F, H, 2-Py, Cl), (M-10809, CH3, F, H, 2-Py, F), (M-10810, CFb, F，H, 2- Py, CF3), (M-10811, CH3, F, H, 2-Py, Br), (M-10812, CH3, F, H, 2-Py, CH3), (M-10813, CH3, F, H, 3-Py, Η), (M-10814, CH3, F, H, 3-Py, Cl), (M-10815, CH3, F, H, 3-Py, F), (M-10816, CH3, F, H, 3-Py, CF3), (M-10817, CH3, F, H, 3-Py，Br)， (M-10818, CH3, F, H, 3-Py, CH3)，（M-10819, CH3, F, H, 4-Py, H)，（M-10820, CHa， F, H, 4-Py, Cl), (M-10821, CH3, F，H, 4-Py, F), (M· 10822, CH3, F, H, 4-Py, CF3)， (M-10823, CH3, F, H, 4-Py, Br), (M-10824, CH3, F, H, 4-Py, CH3), (M-10825, CH3, F, H, 2-Th, Η), (M-10826, CH3, F, H, 2-Th, Cl), (M-10827, CH3, F, H, 2-Th, F), (M-10828, CH3, F, H，2-Th, CF3), (M-10829, CH3, F, H, 2-Th, Br), (M-10830, CH3, F, H, 2-Th, CH3), (M-10831, CH3, F, H, 3-Th, Η), (Μ·10832, CH3, F, H, 3- Th, Cl), (M-10833, CH3, F, H, 3-Th, F), (M-10834, CH3, F, H，3-Th，CF3)， (M-10835, CH3, F, H, 3-Th, Br), (M-10836, CHa, F, H, 3-Th, CHa), (M-10837, CH3, F，H,吡唑-2'基，Η), (M-10838, CH3, F, H，唑-2-基，Cl), (M-10839, CH3, F，H,吡唑-2-基, F), (M-10840, CH3, F，H,吡唑-2·基，CF3), (M· 10841, CH3, F, H,吡唑-2-基，Br), (M-10842, CH3, F, H,吡唑-2-基％ CH3>, ____2IS_______ 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公釐） ii---U.------ <請先閱讀背面之注意事項再填寫本頁) 訂--- 1284639 A7 B7 五、發明說明ο (Μ·1〇843, CH3, F, Η,吡唑-3-基，Η), (M-10844, CH3, F, Η,吡唑-3-碁，Cl)， (M-10845, CH3, F, Η,吡唑-3-棊，F), (M-10846, CH3, F, Η,吡唑-3-基， CF3), (M-10847, CH3, F, H,吡唑-3-基，Br), (M-10848, CH3, F, H,吡唑-3-基，CH3), (M-10849, CHa, F, H,嘧啶-2-基丨> H)· (Μ·108Γ》0· CIIU F. Η· 嘧啶-2-基，Cl), (M-10851, CH3, F, H,嘧啶-2-棊，F), (M-10852, CH3, F, H,嘧啶-2-基，CF3), (M-10853, CH3, F, H,嘧啶-2-基，Br), (M-10854， CH3, F, H,;嘧啶-2-基，CH3), (M-10855, CH3, F, H,嘧啶-4-琴，H), (M-10856, CH3, F, H,嘧啶-4-基，Cl), (M-10857, CH3, F, H,嘧啶-4-基， F), (M-10858, CH3, F, H,嘧啶-4-基，iCF3), (M-10859, CH3, F, Η, 嘧啶-4-基 1, Br), (M-10860, CH3, F, H,嘧啶-4-基，CH3),(M-10861, CH3, F, H,嘧啶-5-基，Η), (M-10862, CH3, F, H,嘧啶-5-基，Cl), (M-10863, CH3, F, H,嘧啶-5-棊，F), (M-10864, CH3, F, H,嘧啶-5 -基，CF3)，（M· 10865, CH3, F, H，嘧啶-5-基，Br), (M-10866, CH3, F, H,嘧啶-5-基， CH3), (M-10867, CHs, F, H, HOOCCH2CH2CH2, Η), (M-10868, CH3, F, H, HOOCCH2CH2CH2, Cl), (M-10869, CHs, F, H, HOOCCH2CH2CH2, F), (M-10870, CH3, F, H, HOOCCH2CH2CH2, CF3), (M-10871, CHa, F, H, HOOCCH2CH2CH2, Br), (M-10872, CHs, F, H, HOOCCH2CH2CH2, CHs), (M-10873, CHs, F, H, HOOCCH2CH2CH2CH2, H), (M-10874, CHa, F, H, HOOCCH2CH2CH2CH2, Cl), (M-10875, CHs, F, H, HOOCCH2CH2CH2CH2, F); (M-10876, CHs, F, H, HOOCCH2CH2CH2CH2, CFs), (M-10877, CH3, F, H, HOOCCH2CH2CH2CII2, Br), (M-10878, CHs, F, H, HOOCCH2CH2CH2CH2, CHs), (M-10879, CHa, F, H, (Me)2NCOCH2CH2CH2CH2, Η), (M-10880, CH3, F, H, (Me)2NCOCH2CH2CH2CH2, Cl), (M-10881, CH3, F, H, (Me)2NCOCH2CH2CH2CH2, F), (M-10882, CH3, F, H, (Me)2NCOCH2CH2CH2CH2, CF3), (M-10883, CH3, F, H, (Me)2NCOCH2CH2CH2CH2, Br), (M-10884, CHa, F, H, _277 _____ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 4 <請先閱讀背面之注意事項再填寫本頁) 訂---------^9. 經濟部智慧財產局員工消費合作社印制衣 1284639 A7 B7 五、發明說明（>外） (Me)2NCOCH2CH2CH2CH2> CHa), (M-10885, CHa, F, H, (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-10886, CH3, F, H, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M· 10887, CH3, F, H, (Me>2NCOCH2CH2CH2CH2CH2, F), (M-10888, CAU, F, H, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M· 10889, CH3, F, H, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-10890, CH3, F, H, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-10891, CH3, F, H，MeOCH2, Η), (M· 10892, CH3, F, H，MeOCH2, Cl), (M-10893, CH3, F, H, MeOCH2, F), (M-10894, CH3, F, H, MeOCH2, CF3), (M-10895, CH3, F, H, MeOCH2, Br), (M-1089G，Clb， F，H, MeOCH2, CH3), (M-10897, CH3, F, H, EtOCH2, Η), (M-10898, CH3, F，H， EtOCH2, Cl), (M-10899, CH3, F, H, EtOCH2, F), (M-10900, CH3, F, H，EtOCH2, CF3), (M-10901, CH3, F, H, EtOCH2, Br), (M-10902, CH3, F, H，EtOCH2, CH3)， (M-10903, CHa, F, H, EtOCH2CH2, Η), (M-10904, CHa, F, H, EtOCH2CH2, Cl), (M-10905, CH3, F, H, EtOCH2CH2, F), (M-10906, CH3, F, H, EtOCH2CH2, CF3), (M-10907, CH3, F, H, EtOCH2CH2, Br), (M-10908, CH3, F, H, EtOCH2CH2, CHs)， (M-10909, CH3, F, H, MeOCH2CH2〇CH2CH2, Η), (M-10910, CH3, F，H， MeOCH2CH2OCH2CH2, Cl), (M-10911, CH3, F, H，MeOCH2CH2〇CH2CH2, F), (M-10912, CH3, F, H, MeOCH2CH2OCH2CH2, CF3), (M-10913, CH3, F, H, MeOCH2CH2〇CH2CH2, Br), (M-10914, CH3, F, H, MeOCH2CH2〇CH2CH2, CH3), (M-10915, CH3, F, H, MeOCH2CH2, Η), (M-10916, CH3, F, H, MeOCH2CH2, Cl), (M-10917, CH3, F, H, MeOCH2CH2, F), (M-10918, CH3, F，H, MeOCH2CH2, CF3)， (M-10919, CH3, F, H, MeOCH2CH2, Br), (M-10920, CH3, F, H, MeOCH2CH2, CH3), (M-10921, CH3, F, H, HOCH2, Η), (M-10922, CH3, F, H, HOCH2, Cl)， (M-10923, CH3, F, H, HOCH2, F), (M-10924, CH3, F, H, HOCH2, CFa), (M-10925, CH3, F, H, HOCH2, Br), (M-10926, CH3, F, H, HOCH2, CHa), (M-10927, CH3, F， H, HOCH2CH2, Η), (M-10928, CHs, F, H, HOCH2CH2, Cl), (M-10929, CH3, F, H, 278 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公爱）
-I:___--------------^--- (請先閱讀背面之注意事項再填寫本頁) 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（巧9) HOCH2CH2, F), (M-10930, CHs, F, H, HOCH2CH2, CFs), (M-10931, CH3, F, Η, HOCH2CH2, Br), (M-10932, CHs, F, H, HOCH2CH2, CHa), (M-10933, CHa, F, H, HOCH2CH2CH2, Η), (M-10934, CHs, F, H, HOCH2CH2CH2, Cl), (M-10935, CHa, F, H, HOCH2CH2CH2, F), (M-10936, CHs, F, H, HOCH2CH2CH2, CF3), (M-10937, CHa, F, H, HOCH2CH2CH2, Br), (M-10938, GH3, F, H, HOCH2CH2CH2, CHa), (M-10939, CHs, F, H, HOCH2CH2CH2CH2, Η), (M-10940, CHs, F, H, HOCH2CH2CH2CH2, Cl), (M-10941, CHs, F, H, HOCH2CH2CH2CH2, F), (M-10942, CHs, F, H, HOCH2CH2CH2CH2, CFs), (M-10943, CHa, F, H, HOCH2CH2CH2CH2, Br), (M-10944, CH3, F, H, HOCH2CH2CII2CH2, CHa), (M-10945, CHs, F, H, HOCH2CH2CH2CH2CH2, Η), (M-10946, CH3, F, H, HOCH2CH2CH2CH2CH2, Cl), (M-10947, CH3, F, H, HOCH2CH2CH2CH2CH2, F), (M-10948, CH3, F, H, HOCH2CH2CH2CH2CH2, CF3), (M-10949, CHa, F, H, HOCH2CH2CH2CH2CH2, Br), (M-10950, CH3, F, H, HOCH2CH2CH2CH2CH2， CH3), (M-10951, CHs, F, H, HOCH2CH2OCH2CH2, Η), (M-10952, CH3, F, H, HOCH2CH2OCH2CH2, Cl), (M-10953, CH3, F, H, HOCH2CH2OCH2CH2, F), (M-10954, CHa, F, H, HOCH2CH2OCH2CH2, CF3), (M-10955, CHa, F, H, HOCH2CH2OCH2CH2, Br), (M-10956, CH3, F, H, HOCH2CH2OCH2CH2, CHa), (M-10957, CH3, F, Η, (Me)2N, Η), (M-10958, CHa, F, H, (Me)2N, Cl), (M-10959, CH3, F, H, (Me)2N, F), (M-10960, CH3, F, H, (Me)2N, CFs), (M-10961, CH3, F，H， (Me)2N, Br), (M-10962, CH3, F, H, (Me)2N, CH3), (M-10963, CHa, F, H， 哌啶-4 基甲基 L Η), (M-10964, CH3, F, H,哌啶-4 -基甲基 1, Cl)， (M-10965, CHs, F, H,哌啶-4-基甲基，F), (M-10966, CH3, F, H, 哌啶-4 基甲基，CFO, (Μ·1〇967, CH3, F，H,哌啶-4 -基甲基 Br): (M-10968, CH3, F, H,哌啶-4-基甲基:，CH3), (M-10969, CH3, F，H, 環己基甲基，Η), (Μ·1097〇, CH3, F, H,環己基甲基，Cl), (M-10971, CH3, F, H,環己基甲基 u F), (M-10972, CH3, F, H,環己基甲基1，CF3), 279 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） -I:---------ί (請先閱讀背面之注意事項再填寫本頁) 訂--- 1284639 A7 B7 五、發明說明（>w) (M-10973, CHa, F, Η,環己基甲基，Br)，（M-10974, CH3, F, Η, (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 環己基甲基，CH3), (M-10975, CH3, F，F, Η, Η), (M-10976, CH3, F，F，Η, Cl), (M-10977, CH3, F, F, H, F), (M-10978, CH3, F, F, H, CF3), (M-10979, CH3, F, F, H, Br>, (M-10980, CHa, F, F, H, CH?〇, (M-10981, CHa· F· F· F· H). (Μ·10982· CHa, F, F, F, Cl), (M-10983, CHs, F, F, F, F), (M-10984, CHa, F, F, F, CFa), (M-10985, CHa, F, F, F, Br), (M-10986, CH3, F, F, F, CH3), (M-10987, CHs, F, F， Cl, Η), (M-10988, CH3, F, F, Cl, Cl), (M-10989, CH3, F, F, Cl, F)，（M-10990, CH3, F, F, Cl, CF3), (M-10991, CH3, F, F, Cl, Br), (M-10992, CH3, F, F, Cl, CH3)， (M-10993, CH3, F, F, CH3, Η), (M-10994, CH3, F, F, CH3, Cl), (M-10995, CH3, F， F, CHs, F), (M-10996, CH3, F, F, CH3, CFs), (M-10997, CH3, F, F, CHa, Br), (M-10998, CH3, F, F, CH3, CH3), (M-10999, CH3, F, F, Et, Η), (M-11000, CH3, F， F, Et, Cl), (M-11001, CH3, F, F, Et, F), (M-11002, CH3, F，F, Et, CF3), (M-11003, CH3, F, F, Et, Br), (M-11004, CH3, F, F, Et, CH3), (M-11005, CH3, F, F, n-Pr, H), (M-11006, CH3, F, F, n-Pr, Cl), (M-11007, CH3, F, F, n-Pr, F), (M-11008, CH3, F， F, n-Pr, CF3), (M-11009, CH3, F, F, n-Pr, Br), (M-11010, CH3, F, F, n-Pr, CH3)， (M-11011, CH3, F, F, c-Pr, Η), (M-11012, CH3, F, F, c-Pr, Cl), (M-11013, CH3, F， F, c-Pr, F), (M-11014, CH3, F, F, c-Pr, CF3), (M-11015, CH3, F, F，c-Pr, Br)， (M-11016, CH3, F, F, c-Pr, CH3), (M-11017, CH3, F，F, i-Pr, Η), (M-11018, CH3, F, F, i-Pr, Cl), (M-11019, CH3, F, F, i-Pr, F), (M-11020, CH3, F, F, i-Pr, CF3)， (M-11021, CH3, F, F, i:Pr, Br), (M-11022, CH3, F, F, i-Pr, CH3)，（M-11023, CH3, F, F, n-Bu, Η), (M-11024, CHs, F, F, n-Bu, Cl), (M-11025, CH3, F, F, n-Bu, F), (M-11026, CH3, F, F, n-Bu, CF3), (M-11027, CH3, F, F, n-Bu, Br), (M-11028， CH3, F, F, n，Bu, CH3), (M-11029, CH3, F，F, i-Bu, Η), (M-11030, CH3, F，F，i· Bu, Cl), (M-11031, CHs, F, F, i-Bu, F), (M-11032, CHa, F, F, i-Bu, CFa), (M-11033, CH3, F, F, i-Bu, Br), (M-11034, CH3, F, F, i-Bu, CH3), (M-11035, CH3, F, F, sec-Bu, Η), (M-11036, CH3, F, F, sec-Bu, Cl), (M-11037, CH3, F, F, sec-Bu, F), _ 280 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 1284639
— ^____一------; (請先閱讀背面之注意事項再填寫本頁) -ϋ n an A7 B7 五、發明說明卜巧） (M-11038, CHs, F, F, sec-Bu, CFs), (M-11039, CH3, F, F, sec-Bu, Br), (M-11040, CH3, F, F, sec-Bu, CH3), (M-11041, CH3, F, F, n-Pen, Η), (M-11042, CH3, F, F, u-Pen, Cl), (M-11043, CHa, F, F, n-Pen, F), (M-11044, CHa, F, F, n-Pen, CFs), (M-11045, CHst Ff Ff n-Pen, Hr), (M-1HM6, Clin, F, F, n-Pnn, CII.m), (M-I I017, CHa, F, F, c-Pen, Η), (M-11048, CHa, F, F, c-Pen, Cl), (M-11049, CH3, F, F, c-Pen, F), (M-11050, CH3, F, F, c-Pen, CFs), (M-11051，CH3, F, F, c-Pen, Br)， (M-11052, CH3, F, F, c-Pen, CHa), (M-11053, CHs, F, F, n-Hex, Η), (M-11054, CH3, F, F, n-Hex, Cl), (M-11055, CH3, F, F, n-Hex, F), (M-11056, CH3, F, F, n-Hex, CFa), (M-11057, CH3, F, F, n-Hex, Br), (M-11058, CHa, F, F, n-Hex, CHs), (M-11059, CH3, F, F, c-Hex, Η), (M-11060, CH3, F, F, c-Hex, Cl), (M-11061, CH3, F, F, c-Hex, F), (M-11062, CH3, F, F, c-Hex, CF3), (M-11063, CH3, F，F，c-Hex， Br)，（M-11064, CH3, F，F, c-Hex, CH3)，（M-11065, CH3, F，F, OH, H)，（Μ·110(56, CH3, F, F, OH, Cl), (M-11067, CH3, F, F, OH, F), (M-11068, CH3, F，F, OH, CF3)， (M-11069, CH3, F, F, OH, Br), (M-11070, CHa, F, F, OH, CHa), (M-11071, CHs, F, F, EtO, Η), (M-11072, CH3, F, F, EtO, Cl), (M-11073, CH3, F, F, EtO, F)， (M-11074, CH3, F, F, EtO, CF3), (M-11075, CH3, F, F, EtO, Br), (M-11076, CH3, F，F, EtO, CH3), (M-11077, CH3, F, F, n-PrO, Η), (M.11078, CH3, F，F, n-PrO, Cl), (M-11079, CHa, F, F, n-PrO, F), (M-11080, CHa, F, F, n-PrO, CFa), (M-11081, CHa, F, F, n-PrO, Br), (M-11082, CHa, F, F, n-PrO, CHa), (M-11083, CHs, F, F, PhO, Η), (M-11084, CH3, F, F, PhO, Cl), (M-11085, CH3, F, F, PhO, F), (M-11086, CH3, F, F, PhO, CF3), (M-11087, CH3, F, F，PhO, Br), (M-11088, CH3, F, F, PhO, CH3), (M-11089, CH3, F, F，BnO, Η), (M-11090, CH3, F, F，BnO, Cl)， (M-11091, CH3, F, F, BnO, F), (M-11092, CHa, F, F, BnO, CFa), (M-11093, CHa, F, F, BnO, Br), (M-11094, CH3, F, F, BnO, CH3), (M-11095, CH3, F, F, PhCH2CH2〇, Η), (M-11096, CH3, F, F, PhCH2CH2〇, Cl)，（M-11097, CH3, F，F， PhCH2CH2〇, F), (M-11098, CH3, F, F, PhCH2CH2〇, CF3)，（Μ-11099, CH3, F, F， 本紙張尺度適用中關家標準（CNS)A4規格⑽x 297公釐） 訂--- 經濟部智慧財產局員Η消費合作社印製 1284639 五、發明說明（>&)
PhCH2CH2〇, Br), (M-11100, CHa, F, F, PhCH2CH2〇, CHa), (M-11101, CHa, F, F, CF3〇, Η), (M-11102, CHa, F, F, CFaO, Cl), (M-11103, CHa, F, F, CFaO, F), (M-11104, CH3, F, F, CF3O, CFs), (M-11105, CHa, F, F, CFaO, Br), (M-11106, CHa, F, F, CF3O, CHs), (Μ-1Π07, CHa, K, F, Ph, II), (M-I liOB, CAht Κ, 1Λ Ni, 01), (M-11109, CHs, F, F, Ph, F), (M-11110, CHa, F, F, Ph, CFs), (M-lllll, CH3, F, F, Ph, Br), (M-11112, CH3, F, F, Ph, CH3), (M-11113, CH3, F, F, 4-F-Ph, H)， (M-11114, CH3, F, F, 4-F-Ph, Cl), (M-11115, CH3, F, F, 4-F-Ph，F), (M-11116， CH3, F, F, 4-F-Ph, CF3), (M-11117, CH3, F, F, 4-F-Ph, Br), (M-11118, CH3, F, F， 4-F-Ph, CHa), (M-11119, CH3, F, F, 4-CF3-Ph, Η), (M-11120, CH3, F, F, 4.CF3-Ph, Cl), (M-11121, CH3, F, F, 4-CF3-Ph, F), (M-11122, CH3, F, F, 4-CF3-Ph，CF3), (M-11123,CH3,F,F,4-CF3-Ph，Br),(M-11124,CH3,F,F,4-CF3-Ph,CH3),(M-11125, CH3, F, F, 4-(Me)2N-Ph, Η), (M-11126, CH3, F, F, 4-(Me)2N-Ph，Cl), (M-11127, CH3, F, F, 4-(Me)2N-Ph，F), (M-11128, CH3, F, F, 4-(Me)2N-Ph，CF3)， (M-11129, CH3, F, F, 4-(Me)2N-Ph, Br), (M-11130, CH3, F, F, 4-(Me)2N-Ph，CH3)， (M-11131, CH3, F, F, 4-OH-Ph, Η), (M-11132, CH3, F, F, 4-OH-Ph, Cl), (M-11133, CH3, F, F, 4-OH-Ph, F), (M-11134, CH3, F, F, 4-OH-Ph, CF3), (M-11135, CH3, F, F, 4-OH-Ph, Br), (M-11136, CH3, F, F, 4-OH-Ph, CH3), (M-11137, CHs， F，F, 3,4-di-F-Ph, Η), (M-11138, CH3, F, F, 3,4-di-F-Ph, Cl), (M-11139, CH3, F， F，3,4-di-F-Ph, F), (M-11140, CH3, F, F, 3,4-di-F-Ph，CF3)，（M-11141, CH3, F，F， 3,4-di-F-Ph, Br), (M-11142, CHs, F, F, 3,4-di-F-Ph, CH3), (M-11143, CH3, F，F, 4-COOH-Ph, Η), (M-11144, CHs, F, F, 4-COOH-Ph, Cl), (M-11145, CHa, F, F, 4-COOH-Ph, F), (M-11146, CH3, F, F, 4-COOH-Ph，CF3), (M-11147, CH3, F, F， 4-COOH-Ph, Br), (M-11148, CH3, F, F, 4-COOH-Ph, CH3), (M-11149, CH3, F，F， Bn, Η), (M-11150, CHs, F, F, Bn, Cl), (M-11151, CHa, F, F, Bn, F), (M-11152, CHa, F, F, Bn, CFa), (M-11153, CHs, F, F, Bn, Br), (M-11154, CHs, F, F, Bn, CH3), (M-11155, CH3, F, F, 4-F-Bn, Η), (M-11156, CH3, F, F, 4-F-Bii，Cl)，（M- &張尺度適用中國國家標準（cns)a4規格（210 χ 考 (請先閱讀背面之注意事項再填寫本頁) 訂--- 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7_ 圓 ___———————w——————*81——— 五、發明說明（><fi) 11157, CHs, F, F, 4-F-Bn, F), (M-11158, CH3, F, F, 4-F-Bn, CFa), (M-11159, CH3, F, F, 4-F.Bn, Br), (M-11160, CHa, F, F, 4-F.Bn, CHa), (M-11161, CHa, F, F, 2-Py, Η), (M-11162, CH3, F, F, 2-Py, Cl), (M-11163, CHs, F, F, 2-Py, F), (M-11164, CH\ F, F, 2-Py, CFa), (Μ·111Γ,β· rjh, P, hVi-Py, 1U>, (Μ·1 1 l(m. (ΊΙι K、K, $
Py, CH3), (M-11167, CH3, F, F, 3-Py, Η), (M-11168, CHs, F, F, 3-Py, Cl), (M-11169, CHs, F, F, 3-Py, F), (M-11170, CHa, F, F, 3-Py, CFa), (M-11171, CHa, F, F, 3-Py, Br), (M-11172, CH3, F, F, 3-Py, CH3), (M-11173, CH3, F, F, 4-Py，H)， (M-11174, CH3, F, F, 4-Py，Cl)，（M-11175, CH3, F, F，4-Py，F)，（M-11176, CH3, F, F, 4-Py, CFa), (M-11177, CHa, F, F, 4-Py, Br), (M-11178, CHa, F, F, 4-Py, CH3), (M-11179, CH3, F, F, 2-Th, Η), (M-11180, CH3, F, F, 2-Th, Cl), (M-11181, CH3, F, F, 2-Th, F), (M-11182, CH3, F, F, 2-Th, CF3), (M-11183, CH3, F, F，2-Th，Br), (M-11184, CH3, F, F, 2-Th, CH3)，（M-11185, CH3, F, F, 3-Th, H), (M-1118G, CH3, F, F, 3-Th，Cl)，（M-11187, CH3, F, F，3-Th，F), (M-11188, CH3, F, F, 3-Th，CF3)， (M-11189, CHa, F, F, 3-Th, Br), (M-11190, CHa, F, F, 3-Th, CHa), (M-11191, CH3, F, F,吡唑-2-基，H), (M-11192, CH3, F, F,吡唑-2-棊，¢1), (M-11193，CH3, F, F,吡唑-2-基，F)，（M-11194, CHa, F, F,:吡唑-2-基，CF3)，（M-11195, CH3, F，F,吡唑-2-基，Br), (M-11196, CH3, F, F,吡唑-2-基，CH3)，（M-11197， CH3, F,F,吡唑·3·基，Η)，（Μ·11198, CH3, F, F,吡唑-3-基，Cl), (M-11199, CH3, F, F,吡唑-3-基，F), (M-11200, CH3, F，F,吡唑-3-基，CF3), (M-11201， CH3, F, F, _壯唑-3·基，Br), (M-11202, CH3, F, F,吡唑-3-基，CH3), (M· 11203, CH3, F, F，嘧啶-2-基，Η), (M-11204, CH3, F, F,嘧啶-2-基，Cl)， (Μ·11205, CH3, F，F,嘧啶-2-基，F), (M-11206, CH3, F，F,嘧卩定-2-基， CF3), (M-11207, CH3, F, F,嘧啶-2-基，Br), (M-11208, CH3, F，F， 嘧啶-2-基，CH3>，（M-11209, CH3, F, F,嘧啶-4-基，H>，（M-11210, CH3, F, F,嘧啶-4-基，Cl), (M-11211, CH3, F, F,嘧啶-4-基，F)，（M-11212， CH3, F, F,嘧啶-4-基、CF3), (M.11213, CH3, F，F，嘧啶-4-基，Br)，（M- ____________ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 1 I I I I · I ϋ I mM— (請先閱讀背面之注意事項再填寫本頁) 訂--- 經濟部智慧財產局員工消費合作社印製 1284639 一 A7 _ B7____ 五、發明說明（>心） 11214, CH3, F, F,嘧啶-4-基，CH3), (M-11215, CHa, F, F,嘧啶-5-基，H)， (M-11216, CH3, F, F,嘧啶-5-基，Cl), (M-11217, CH3, F，F,嘧啶-5-基， F), (M-11218, CH3, F, F,嘧啶-5-基，CF3), (M-11219, CH3, F，F, 嘧啶-5-基，(Μ·11220. ΠΠη, F, F·嘧啶-5-基· Γ!Ηη)·(Μ·1 Γ252Ι. (Hi F, F, HOOCCH2CH2CH2, Η), (M-11222, CHs, F, F, HOOCCH2CH2CH2, Cl), (M-11223, CH3, F, F, HOOCCH2CH2CH2, F), (M-11224, CH3, F, F, HOOCCH2CH2CH2, CF3), (M-11225, CH3, F, F, HOOCCH2CH2CH2, Br)，（M- 11226, CHs, F, F, HOOCCH2CH2CH2, CHa), (M-11227, CHa, F, F, HOOCCH2CH2CH2CH2, Η), (M-11228, CHa, F, F, HOOCCH2CH2CH2CH2, Cl), (M-11229, CHs, F, F, HOOCCH2CH2CH2CH2, F), (M-11230, CHs, F, F, HOOCCH2CH2CH2CH2, CF3), (M-11231, CHs, F, F, HOOCCH2CH2CH2CH2, Br), (M-11232, CH3, F, F, HOOCCH2CH2CH2CH2, CHa), (M-11233, CHa, F, F, (Me)2NCOCH2CH2CH2CH2, Η), (M-11234, CH3, F, F, (Me)2NCOCH2CH2CH2CH2, Cl), (M-11235, CH3, F, F, (Me)2NCOCH2CH2CH2CH2, F), (M-11236, CH3, F, F, (Me)2NCOCH2CH2CH2CH2, CF3), (M-11237, CH3, F, F, (Me)2NCOCH2CH2CH2CH2, Br), (M-11238, CH3, F, F, (Me)2NCOCH2CH2CH2CH2, CH3), (M-11239, CH3, F, F, (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-11240, CH3, F, F, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-11241, CH3, F, F, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-11242, CH3, F, F， (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-11243, CH3, F，F， (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-11244, CH3, F, F, (Me)2NCOCH2CH2CH2CH2CH2, CHa), (M-11245, CH3, F, F, MeOCH2, Η), (M-11246, CH3, F, F, MeOCH2, Cl)，（M-11247, CH3, F, F, MeOCH2, F), (M-11248, CH3, F, F, MeOCH2, CF3), (Μ·11249, CH3, F, F, MeOCH2, Br)，（M-11250, CH3, F， __2M_____ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 1^----1--------------β--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 + A7 _B7___ 五、發明說明) F, MeOCH2, CH3), (M-11251, CH3, F, F, EtOCH2, Η), (M-11252, CH3, F，F， EtOCH2, Cl), (M-11253, CH3, F, F, EtOCH2, F), (M-11254, CH3, F, F，EtOCH2, CFa), (M-11255, CH3, F, F, EtOCH2, Br), (M-11256, CH3, F, F，EtOCH2, CH3)， (M-11257, CHa, F, F, EtOCIhCIh, Η), (Μ-112Γ)8, CTIn, F, F, RtOClhCIh, Cl), (M-11259, CH3, F, F, EtOCH2CH2, F), (M-11260, CH3, F, F, EtOCH2CH2, CF3), (M-11261, CHa, F, F, EtOCH2CH2, Br), (M-11262, CHa, F, F, EtOCH2CH2, CHa), (M-11263, CH3, F, F, MeOCH2CH2〇CH2CH2, Η), (M-11264, CH3, F, F， MeOCH2CH2〇CH2CH2, Cl), (M-11265, CH3, F, F, MeOCH2CH2〇CH2CH2, F)， (M-11266, CH3, F, F, MeOCH2CH2OCH2CH2, CF3), (M-11267, CH3, F，F, MeOCH2CH2〇CH2CH2, Br), (M-11268, CH3, F, F，MeOCH2CH2〇CH2CH2, CH3)， (M-11269, CH3, F, F, MeOCH2CH2, Η), (M-11270, CH3, F, F, MeOCH2CH2, Cl), (M-11271, CH3, F, F, MeOCH2CH2, F), (M-11272, CH3, F, F, MeOCH2CH2, CF3)， (M-11273, CH3, F, F, MeOCH2CH2, Br)，（M-11274, CH3, F, F，MeOCH2CH2, CHs), (M-11275, CH3, F, F, HOCH2, Η), (M-11276, CHa, F, F, HOCH2, Cl), (M-11277, CHa, F, F, HOCH2, F), (M-11278, CHa, F, F, HOCH2, CFa), (M-11279, CH3, F, F, HOCH2, Br), (M-11280, CH3, F, F, HOCH2, CH3), (M-11281, CH3, F， F, HOCH2CH2, Η), (M-11282, CH3, F, F, HOCH2CH2, Cl), (M-11283, CHa, F, F, HOCH2CH2, F), (M-11284, CH3, F, F, HOCH2CH2, CF3), (M-11285, CH3, F, F， HOCH2CH2, Br), (M-11286, CHa, F, F, HOCH2CH2, CHa), (M-11287, CH3, F, F, HOCH2CH2CH2, Η), (M-11288, CHa, F, F, HOCH2CH2CH2, Cl), (M-11289, CHa, F, F, HOCH2CH2CH2, F), (M-11290, CHs, F, F, HOCH2CH2CH2, CFa), (M-11291, CHs, F, F, HOCH2CH2CH2, Br), (M-11292, CH3, F, F, HOCH2CH2CH2, CH3), (M-11293, CHa, F, F, HOCH2CH2CH2CH2, Η), (M-11294, CHa, F, F, HOCH2CH2CH2CH2, Cl), (M-11295, CHa, F, F, HOCH2CH2CH2CH2, F), (M-11296, CH3, F, F, HOCH2CH2CH2CH2, CFa), (M-11297, CH3, F, F, HOCH2CH2CH2CH2, Br), (M-11298, CHa, F, F, HOCH2CH2CH2CH2, CHa), (M- _285_ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） . —^--------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五、發明說明 11299, CHa, F, F, HOCH2CH2CH2CH2CH2, Η), (M-11300, CH3, F, F, HOCH2CH2CH2CH2CH2, Cl), (M-11301, CHs, F, F, HOCH2CH2CH2CH2CH2, F), (M-11302, CH3, F, F, HOCH2CH2CH2CH2CH2, CFa), (M-11303, CHa, F, F, HOCH2CH2CH2CH2CH2, Br), (M-11304, CH.i, F, F, UOCAhCW^ClhCU^CU^, CH3), (M-11305, CH3, F, F, HOCH2CH2〇CH2CH2, Η), (M-11306, CH3, F, F, HOCH2CH2OCH2CH2, Cl), (M-11307, CHa, F, F, HOCH2CH2OCH2CII2, F). (M-11308, CHa, F, F, HOCH2CH2OCH2CH2, CFa), (M-11309, CH3, F, F, HOCH2CH2〇CH2CH2, Br), (M-11310, CHa, F, F, HOCH2CH2OCH2CH2, CH3), (M-11311, CHa, F, F, (Me)2N, Η), (M-11312, CHs, F, F, (Me)2N, Cl), (M-11313, CH3, F, F, (Me)2N, F), (M-11314, CH3, F, F, (Me)2N, CF3), (M-11315, CH3, F, F， (Me)2N, Br), (M-11316, CH3, F, F, (Me)2N, CH3>, (M-11317, CH3, F，F, 哌啶-4-基甲基;，Η), (Μ·11318, CH3, F, F,:哌啶-4-基甲基，Cl), (M-11319, CH3, F, F,哌啶-4-棊甲基!，F), (M-11320, CH3, F，F, 哌啶-4 -基甲基，CF3), (M-11321, CH3, F, F,哌啶-4 -基甲基，Br)， (M-11322, CH3, F, F,哌啶-4-基甲基，CH3), (M-11323, CH3, F, F, 環己基甲基 l, Ή), (M-11324, CH3, F, F,環己基甲基,Cl), (M-11325， CH3, F, F,環己基甲棊，F)，（M-11326, CH3, F, F,環己基甲基，CF3>， (M-11327, CH3, F, F,環己基甲基，Br), (M_11328, CH3, F, F， 環己基甲基，CH3), (M-11329, CH3, F, Cl, Η, Η), (M-11330, CH3, F, Cl，H， Cl), (M-11331, CHs, F, Cl, H, F), (M-11332, CHa, F, Cl, H, CFa), (M-11333, CH3, F, Cl, H, Br), (M-11334, CHa, F, Cl, H, CH3), (M-11335, CH3, F, Cl, F, Η), (M-11336, CH3, F, Cl, F, Cl), (M-11337, CH3, F, Cl, F, F)，（M-11338, CH3, F，Cl，F, CF3), (M-11339, CHa, F, Cl, F, Br), (M-11340, CHa, F, Cl, F, CHa), (M-11341, CH3, F, Cl, Cl, Η), (M-11342, CH3, F, Cl, Cl, Cl), (M-11343, CH3, F，Cl, Cl，F)， (M-11344, CHa, F, Cl, Cl, CFs), (M-11345, CHs, F, Cl, Cl, Br), (M-11346, CH3, F, Cl, Cl, CH3), (M-11347, CH3, F, Cl, CH3, Η), (M-11348, CH3, F，Cl, CH3, Cl)， ____9«^ _-____ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公爱） (請先閱讀背面之注意事項再填寫本頁) 訂--- 經濟部智慧財產局員工消費合作社印製 1284639
五、發明說明（D (M-11349, CH3, F, Cl, CHa, F), (M-11350, CHa, F, Cl, CHs, CFa), (M-11351, CH3. F, Cl, CHa, Br), (M-11352, CHa, F, Cl, CHa, CH3), (M-11353, CHa, F, Cl, Et, H), (M-11354, CH3, F, Cl, Et, Cl), (M-11355, CH3, F, Cl, Et, F), (M-11356, CH3, F,
Cl, Et, CF3), (M-11357, CIL% F, Cl, FA· Br)· (Μ·1 1358, rjh· l·' (儿 Kt. rUU)· (M-11359, CHs, F, Cl, n-Pr, Η), (M-11360, CHs, F, Cl, n-Pr, Cl), (M-11361, CH3, F, Cl, n-Pr, F), (M-11362, CH3, F, Cl, n-Pr, CF3), (M-11363, CHa, F, Cl, n-Pr, Br), (M-11364, CH3, F, Cl, n-Pr, CH3), (M-11365, CHs, F, Cl, c-Pr, Η), (M-11366、 CH3, F, Cl, c-Pr, Cl), (M-11367, CH3, F, Cl, c-Pr, F), (M-11368, CHa, F, Cl, c-Pr, CF3), (M-11369, CH3, F, Cl, c-Pr, Br), (M-11370, CHa, F，Cl, c-Pr, CH3)， (M-11371, CH3, F, Cl, i-Pr, H)，（M-11372, CH3, F，Cl, i-Pr, Cl), (M-11373, CH3, F, Cl, i-Pr, F), (M-11374, CH3, F, Cl, i-Pr, CF3)，（M-11375, CH3, F, Cl, i-Pr，Br)， (M-11376, CH3, F, Cl, i-Pr, CH3), (M-11377, CH3, F, Cl, η·Βιι，II), (M-11378， CH3, F, Cl, n-Bu, Cl), (M-11379, CH3, F, Cl, n-Bu, F), (M-11380, CH3, F, Cl, η·Βιι, CF3), (M-11381, CH3, F, Cl, n-Bu, Br), (M-11382, CH3, F, Cl, η·Βιι，CH3)， (M-11383, CH3, F, Cl, i-Bu, Η), (M-11384, CH3, F, Cl, i-Bu, Cl)，（M-11385, CH3, F, Cl, i-Bu, F), (M-11386, CH3, F, Cl, i-Bu, CFa), (M-11387, CHa, F, Cl, i-Bu, Br), (M-11388, CHa, F, Cl, i-Bu, CH3), (M-11389, CHa, F, Cl, sec-Bu, Η), (M-11390, CH3, F, Cl, sec-Bu, Cl), (M-11391, CH3, F, Cl, sec-Bu, F), (M.11392, CH3, F，Cl, sec-Bu, CF3), (M-11393, CH3, F, Cl, sec-Bu, Br), (M-11394, CH3, F, Cl, sec-Bu, CH3), (Μ-11395, CHa, F, Cl, n-Pen, Η), (M-11396, CHa, F, Cl, n-Pen, Cl), (M-11397, CH3, F, Cl, n-Pen，F), (M-11398, CH3, F, Cl，n-Pen, CF3), (M-11399, CH3, F, Cl, n-Pen, Br), (M-11400, CH3, F, Cl, n-Pen，CHs)，（M-11401，CH3, F，Cl, c-Pen, Η), (M-11402, CH3, F, Cl, c-Pen, Cl), (M-11403, CH3, F，Cl，c-Pen, F)， (M-11404, CHa, F, Cl, c-Pen, CF3), (M-11405, CH3, F, Cl, c-Pen, Br)，（Μ·11406, CHs, F, Cl, c-Pen, CH3), (M-11407, CHa, F, Cl, n-Hex, Η), (M-11408, CH3, F, Cl, n-Hex, Cl), (M-11409, CHa, F, Cl, n-Hex, F), (M-11410, CH3, F, Cl, n-Hex, CF3), ___9.R7 ___ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） -考 (請先閱讀背面之注意事項再填寫本頁) 訂— 經濟部智慧財產局員Η消費合作社印製 1284639 五、發明說明（ (M-11411, CHs, F, Cl, n-Hex, Br), (M-11412, CHa, F, Cl, n-Hex, CHa), (M-11413, CH3, F, Cl, c-Hex, Η), (M-11414, CH3, F, Cl, c-Hex, Cl), (M-11415, CH3, F, Cl, c-Hex, F), (M-11416, CHa, F, Cl, c-Hex, CFa), (M-11417, CH3, F, Cl, c-Hex, Br), (M-11418, CII3, F, Cl, c-IIox, Clin), (M-1 H19, (ΊΙη, K, Cl, OH. Π), (M-t M20, CH3, F, Cl, OH, Cl), (M-11421, CHa, F, Cl, OH, F), (M-11422, CHa, F, Cl, OH, CF3), (M-11423, CH3, F, Cl, OH, Br), (M-11424, CHa, F, Cl, OH, CH3), (M-11425, CH3, F, Cl, EtO, Η), (M-11426, CH3, F, Cl, EtO, Cl), (M-11427, CH3, F, Cl，EtO, F)，（M-11428, CH3, F, Cl, EtO, CF3), (M-11429, CH3, F, Cl, EtO, Br)，（M-11430, CH3, F, Cl, EtO, CH3), (M-11431，CHs, F, Cl，n-PrO, H)，（M-11432, CHs，F, Cl, n-PrO, Cl), (M-11433, CHa, F, Cl, n-PrO, F), (M-11434, CHa, F, Cl, n-PrO, CFs), (M-11435, CH3, F, Cl, n-PrO, Br), (Μ·11436, CH3, F, Cl, n-PrO, CH3), (Μ·11437, CHa, F, Cl, PhO, Η), (M-11438, CHs, F, Cl, PhO, Cl), (M-11439, CIU, F, Cl FhO, F), (M-11440, CHa, F, Cl, PhO, CFa), (M-11441, CHs, F, Cl, PhO, Br), (M-11442, CH3, F，Cl, PhO, CH3), (M-11443, CH3, F, Cl, BnO, Η), (M-11444, CH3, F, Cl， BnO, Cl), (M-11445, CH3, F，Cl, BnO, F), (M-11446, CH3, F, Cl, BnO, CF3), (M-11447, CH3, F, Cl, BnO, Br), (M-11448, CH3, F, Cl, BnO, CH3), (M-11449， CH3, F, Cl, PI1CH2CH2O, Η), (Μ·11450, CH3, F, Cl, PhCH2CH2〇, Cl), (M-11451， CHa, F, Cl, PhCH2CH2〇, F), (M-11452, CHa, F, Cl, PhCH2CH2〇, CFa), (M-11453, CH3, F, Cl, PhCH2CH2〇, Br), (M-11454, CH3, F, Cl, PhCH2CH2〇, CH3)， (M-11455, CHa, F, Cl, CF3〇, Η), (M-11456, CHa, F, Cl, CF3〇, Cl), (M-11457, CH3, F, Cl, CF3〇, F), (M-11458, CH3, F, Cl, CF3〇, CF3), (M-11459, CH3, F, Cl, CFaO, Br), (M-11460, CH3, F, Cl, CF3〇, CH3), (M-11461, CHa, F, Cl, Ph, H), (M-11462, CHa, F, Cl, Ph, Cl), (M-11463, CH3, F, Cl, Ph, F), (M-11464, CHs, F, Cl, Ph, CFs), (M-11465, CHa, F, Cl, Ph, Br), (M-11466, CHs, F, Cl, Ph, CH3), (M-11467, CHa, F, Cl, 4-F-Ph, H), (M-11468, CHa, F, Cl, 4-F-Ph, Cl), (M-11469, CH3, F, Cl, 4-F-Ph, F), (M-11470, CH3, F, Cl, 4-F-Ph, CF3), (M-11471, CH3, F，Cl, ________ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公髮） -考 (請先閱讀背面之注意事項再填寫本頁) 訂— 經濟部智慧財產局員工消費合作社印製 A7 1284639 B7___ 五、發明說明) 4-F-Ph, Br), (M-11472, CH3, F, Cl, 4-F-Ph, CH3), (M-11473, CHa, F, Cl, 4-CF3-Ph，Η), (M-11474, CH3, F, Cl, 4-CF3-Ph, Cl), (M-11475, CH3, F, Cl, 4-CF3-Ph，F), (M-11476, CH3, F, Cl, 4-CF3-Ph, CF3), (M-11477, CH3, F, Cl, 4-CF3-Ph, Br)， (Μ·11478, CH3, F, Cl, 4-CF3-Ph，Cih), (Μ-11Ί79, Ciln, F, Cl. 4·(Μο)3Ν*Πι· ll)· (M-11480, CH3, F, Cl, 4-(Me)2N-Ph, Cl)，（M-11481, CH3, F, Cl, 4-(Me)2N-Ph, F), (M-11482, CH3, F, Cl, 4-(Me)2N-Ph, CF3), (M-11483, CH3, F, Cl, 4-(Me)2N'Ph， Br), (M-11484, CH3, F, Cl, 4-(Me)2N-Ph, CH3), (M-11485, CH3, F，Cl, 4-OH-Ph， H)，（M-11486, CH3, F, Cl, 4-OH-Ph, Cl), (M-11487, CH3, F，Cl，4-OH-Ph，F), (M-11488, CH3, F, Cl, 4-OH-Ph，CF3)，（M-11489, CH3, F, Cl, 4-OII-Ph, Br), (M-11490, CH3, F, Cl, 4-OH-Ph, CH3), (M-11491，CH3, F, Cl, 3,4-di-F-Ph，H)， (M-11492, CH3, F, Cl, 3,4-di-F-Ph, Cl), (M-11493, CH3, F, Cl, 3,4-di-F-Ph，F)， (M-11494, CH3, F, Cl, 3,4-di-F-Ph, CF3), (M-11495, CH3, F, Cl，3,4.di-F-Ph，Br)、 (M-11496, CH3, F, Cl, 3,4-di-F-Ph, CH3), (M-11497, CH3, F, Cl, 4-COOH-Ph，H)， (M-11498, CH3, F，Cl, 4-COOH-Ph，Cl), (M-11499, CH3, F, Cl, 4-COOH-Ph, F>, (M-11500, CH3, F, Cl, 4-COOH-Ph, CF3), (M-11501, CH3, F, Cl, 4-COOH-Ph, Br), (M-11502, CH3, F, Cl, 4-COOH-Ph, CHa), (M-11503, CH3, F, Cl, Bn, H), (M-11504, CHs, F, Cl, Bn, Cl), (M-11505, CHa, F, Cl, Bn, F), (M-11506, CH3, F, Cl, Bn, CFs), (M-11507, CHs, F, Cl, Bn, Br), (M-11508, CII3, F, Cl, Bn, CH3), (M-11509, CH3, F, Cl, 4-F-Bn, H)，（M-11510, CH3, F, Cl, 4-F-Bn，Cl), (M-11511， CH3, F，Cl, 4-F-Bn, F), (M-11512, CH3, F, Cl, 4-F-Bn, CF3), (M-11513, CH3, F， Cl,4-F-Bn，Br)，（M-11514,CH3,F,Cl，4-F-Bn,CH3)，（M-11515，CH3，F，Cl，2-Py, Η), (M-11516, CHa, F, Cl, 2-Py, Cl), (M-11517, CHa, F, Cl, 2-Py, F), (M-11518, CH3, F, Cl, 2-Py, CF3), (M-11519, CH3, F, Cl, 2-Py, Br)，（Μ·11520, CH3, F, Cl, 2-Py，CH3), (M-11521，CII3, F, Cl, 3-Py, Η), (M-11522, CH3, F, Cl，3-Py, Cl)，（M-11523, CH3, F, Cl, 3-Py, F), (M-11524, CH3, F, Cl, 3-Py, CF3), (M-11525, CH3, F, Cl, 3-Py, Br), (M-11526, CH3, F, Cl, 3-Py, CH3), (M-11527, CH3, F，Cl， 289 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ___!____.--------------訂 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明GM) 4-Py, Η), (M-11528, CHa, F, Cl, 4-Py, Cl), (M-11529, GHa, F, Cl, 4-Py, F), (M-11530, CHa, F, Cl, 4-Py, CFa), (M-11531, CH3, F, Cl, 4-Py, Br), (M-11532, CH3, F, Cl, 4-Py, CHs), (M-11533, CHs, F, Cl, 2-Th, Η), (M-11534, CH3, F, Cl, 2-Th, Cl), (M-11535, CH3, F, Cl, 2-Th, F), (M-11536, CH3, F, Cl, 2-Th’ CF3), (M-11537, CH3, F, Cl, 2-Th, Br), (M-11538, CH3, F, Cl, 2-Th, CH3), (M-11539, CH3, F, Cl, 3-Th, Η), (M-11540, CH3, F, Cl, 3-Th, Cl), (M-11541, CH3, F, Cl, 3-Th，F), (M· 11542, CHa, F, Cl, 3-Th, CF3>，（M-11543, CH3, F, Cl, 3-Th, Br), (M-11544, CH3, F, Cl, 3-Th, CH3), (M-11545, CH3, F, Cl,吡唑·2·基，Η), (M-11546, CH3, F，Cl， 嗤-2-基，Cl), (M-11547, CH3, F，Cl，吡唑-2-基，F)，（M-11548, CHs，F，Cl， Ift 哗-2-基，CF3)，（M-11549, CH3, F，Cl,吡唑-2-基，Br>，（M-11550, CH3, F， Cl,吡唑-2_基，（^3),(1^11551,0113,?,€：1,吡唑-3-基，11)，（1^-11552,(^3, F, Cl,壯唑·3-基,Cl), (M-11553, CH3, F, Cl,吡唑-3-基* F)，（Μ·11554, CH3, F, Cl,壯唑·3-基，CF3), (M-11555, CH3, F, Cl,吡唑-3-基，I3r)，（M-11556, CH3, F, Cl,吡唑-3-基，CH3), (M-11557, CH3, F, Cl,嘧啶-2-基，Η), (M· 11558, CH3,F, Cl,嘧啶-2-基，Cl), (M-11559, CH3, F, Cl,嘧啶-2-基，F), (M-11560, CH3, F, Cl,磅啶-2-基，CF3>, (Μ·11561, CH3, F, Cl,嘧啶-2-基 1, Br), (M-11562, CH3, F, Cl,嘧啶-2-基，CH3), (M-11563, CH3, F, Cl， 嘧啶-4-基，H), (M-11564, CH3, F, Cl,嘧啶 _4-基，C1)，（M-115G5，CH3、F、 Cl,嘧啶-4-'基,F), (M.11566, CH3, F, Gl，，嘧啶-4-基I, CF3), (M-11567， CH3, F, Cl,嘧 II定-4-基，Br), (M-11568, CH3, F，Cl,嘧陡-4-基，CH3)， (M-11569, CH3, F, Cl,嘧啶-5-基，Η), (Μ·11570, CH3, F，Cl,嘧啶-5-基 Cl ), (M-11571, CH3, F, Cl,嘧啶-5-¾ , F), (M-11572, CH3, F，Cl， 嘧啶-5-基 I CF3)，（M-11573, CH3, F，Cl,嘧 n定-5-基，Bi〇,（M-11574, CHs， F, Cl,嘧啶細 5-基，0出)，（1^-11575,0113,卩，〇1,110000112〇112€；112,11),(1^· 11576, CH3, F, Cl, HOOCCH2CH2CH2, Cl), (M-11577, CH3, F, Cl, HOOCCH2CH2CH2, F), (M-11578, CHa, F, Cl, HOOCCH2CH2CH2, CFa), (M- _ 290 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公爱） --------^---------^_^w— (請先閱讀背面之注意事項再填寫本頁) 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（>行） 11579, CHa, F, Cl, HOOCCH2CH2CH2, Br), (M-11680, CH3, F, Cl, HOOCCH2CH2CH2, CHa), (M-11581, CHs, F, Cl, HOOCCH2CH2CH2CH2, H), (M-11582, CHa, F, Cl, HOOCCH2CH2CH2CH2, Cl), (M-11583, CH3, F, Cl, HOOCCH2CH2CH2CH2, F), (M-11584, CHa, F, Cl, HOOCCH2CH2CH2CH2, CFa), (M-11585, CH3, F, Cl, HOOCCH2CH2CH2CH2, Br), (M-11586, CH3, F，Cl， HOOCCH2CH2CH2CH2, CH3), (M-11587, CH3, F, Cl, (Me)2NCOCH2CH2CH2CH2, Η), (M-11588, CH3, F, Cl, (Me)2NCOCH2CH2CH2CH2, Cl), (M-11589, CH3, F，Cl， (Me)2NCOCH2CH2CH2CH2, F), (M-11590, CH3, F, Cl, (Me)2NCOCH2CH2CH2CH2, CFs), (M-11691, CHa, F, Cl, (Me)2NCOCH2CH2CH2CH2, Br), (M-11592, CH3, F, Cl, (Me)2NCOCH2CH2CH2CH2, CH3), (M-11593, CH3, F, Cl， (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-11594, CH3, F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-11595, CH3, F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, F>, (M-11596, CH3, F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-11597, CH3, F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-11698, GHs, F, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-11599, CH3, F, Cl, MeOCH2, Η), (M· 11600, CHa, F, Cl, MeOCH2, Cl), (M-11601, CHa, F, Cl, MeOCH2, F), (M-11602, CH3, F, Cl, MeOCH2, CF3), (Μ·11603, CH3, F, Cl, MeOCH2, Br>, (M-11604, CH3, F, Cl, MeOCH2, CH3) JM-11605, CH3, F, Cl, EtOCH2, Η), (M-11606, CHa, F, Cl, EtOCH2, Cl), (M-11607, CH3, F, Cl, EtOCH2, F), (M-11608, CH3, F, Cl, EtOCH2, CF3), (M-11609, CHa, F, Cl, EtOCH2, Br), (M-11610, CHa, F, Cl, EtOCH2, CH3), (M-11611, CH3, F, Cl, EtOCH2CH2, Η), (M-11612, CH3, F, Cl, EtOCH2CH2, Cl>, (M-11613, CH3, F, Cl, EtOCH2CH2, F), (M-11614, CH3, F, Cl, EtOCH2CH2, CF3)， (M-11615, CH3, F, Cl, EtOCH2CH2, Br), (M-11616, CH3, F, Cl, EtOCH2CH2， CH3), (M-11617, CH3, F, Cl, MeOCH2CH2〇CH2CH2, Η), (M-11618, CH3, F，Cl， 291 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） --------訂--------- (請先閱讀背面之注意事項再填寫本頁) A7 1284639 -------B7___ 五、發明說明（>9〇 )
MeOCH2CH2〇CH2CH2, Cl), (M-11619, CH3, F, Cl, MeOCH2CH2OCH2CH2, F)， (M-11620, CH3, F, Cl, MeOCH2CH2〇CH2CH2, CF3), (M-11621, CH3, F, Cl, MeOCH2CH2〇CH2CH2, Br), (M-11622, CH3, F, Cl, MeOCH2CH2〇CH2CH2,
CH3), (M-11623, CH3, F, Cl，MeOCH2CH2, Η), (M-11624, CH3, F, Cl, MeOCH2CH2, Cl), (M-11625, CHa, F, Cl, MeOCH2CH2, F), (M-11626, CHa, F, Cl, MeOCH2CH2, CFa), (M-11627, CHa, F, Cl, MeOCH2CH2, Br), (M-11628, CHs, F, Cl, MeOCH2CH2, CHa), (M-11629, CHa, F, Cl, HOCH2, Η), (M-11630, CH3, F, Cl, HOCH2, Cl), (M-11631, CHa, F, Cl, HOCH2, F), (M-11632, CHa, F, Cl, HOCH2, CF3), (M-11633, CH3, F, Cl，HOCH2, Br), (Μ·11634, CH3, F, Cl, HOCH2, CH3), (M-11635, CHs, F, Cl, HOCH2CH2, Η), (M-11636, CHa, F, Cl, HOCH2CH2, Cl), (M-11637, CHa, F, Cl, HOCH2CH2, F), (M-11638, CHa, F, Cl, HOCH2CH2, CFs), (M-11639, CHa, F, Cl, HOCH2CH2, Br), (M-11640, CHs, F, Cl, HOCH2CH2, CHa), (M-11641, CHa, F, Cl, HOCH2CH2CH2, Η), (M-11642, CH3, F, Cl, HOCH2CH2CH2, Cl), (M-11643, CHa, F, Cl, HOCH2CH2CH2, F), (M-11644, CHa, F, Cl, HOCH2CH2CH2, CFs), (M-11645, CHa, F, Cl, HOCH2CH2CH2, Br), (M-11646, CHa, F, Cl, HOCH2CH2CH2, CHa), (M-11647, CHa, F, Cl, HOCH2CH2CH2CH2, Η), (M-11648, CHa, F, Cl, HOCH2CH2CH2CH2, Cl), (M-11649, CHa, F, Cl, HOCH2CH2CH2CH2, F), (M-11660, CHs, F, Cl, HOCH2CH2CH2CH2, CFs), (M-11651, CHs, F, Cl, HOCH2CH2CH2CH2, Br), (M-11652, CHa, F, Cl, HOCH2CH2CH2CH2, CH3), (M-11653, CH3, F, Cl, HOCH2CH2CH2CH2CH2, Η), (M-11654, CH3, F, Cl, HOCH2CH2CH2CH2CH2, Cl), (M-11655, CHs, F, Cl, HOCH2CH2CH2CH2CH2, F), (M-11656, CHa, F, Cl, HOCH2CH2CH2CH2CH2, CFa), (M-11657, CHa, F, Cl, HOCH2CH2CH2CH2CH2, Br), (M-11658, CHa, F, Cl, HOCH2CH2CH2CH2CH2, CH3), (M-11659, CHa, F, Cl, HOCH2CH2OCH2CH2, Η), (M-11660, CH3, F, Cl, HOCH2CH2OCH2CH2, Cl)， (M-11661, CHa, F, Cl, HOCH2CH2OCH2CH2, F), (M-11662, CHa, F, CL 292 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -------------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明（>?f) HOCH2CH2OCH2CH2, CFs), (M-11663, CHs, F, Cl, HOCH2CH2OCH2CH2, Br), (M-11664, CHs, F, Cl, HOCH2CH2OCH2CH2, CHs), (M-11665, CH3, F, Cl, (Me)2N, Η), (M.11666, CH3, F, Cl, (Me)2N, Cl), (M-11667, CH3, F, Cl, (Me)2N, F), (M-11668, CH3, F, Cl, (Me)2N, CF3), (M-11669, CHa, Ff Cl, (Me)2N, Br), (M-11670, CH3, F, Cl, (Me)2N, CH3), (M-11671, CH3, F, Cl,哌啶-4 -基甲棊 I， Η), (M-11672, CH3, F, Cl,哌啶-4 - 基甲基 1，Cl), (M-11673, CH3, F，Cl， 哌碇-4 -基甲基，F), (M-11674, CH3, F, Cl,哌啶-4-基甲基>0卩3)， (Μ·11675, CH3, F, Cl,哌啶-4-基甲基，Br), (M-11676, CH3, F, Cl, 哌啶-4-基甲基_ CH3), (Μ·11677, CII3, F, Cl,環己基甲基，11)，（!^· 11678, CH3, F, Cl,環己基甲基，〇1),(1^-11679,0：113，卩，〇1， 環己基甲基，F), (M·11680, CH3, F，C1，環己基甲基，CF3)，（M·11681， CH3, F, Clj環己基甲基，Br), (M-11682, CH3, F, Cl,環己基甲基， CH3), (M-11683, CH3, CH3, Η, Η, Η), (M-11684, CH3, CH3, H，H, Cl), (M-11685, CH3, CH3, Η, H, F), (M-11686, CH3, CH3, Η, H, CF3), (M-11687, CH3, CH3, Η, H， Br), (M-11688, CH3, CH3, Η, H, CH3), (M-11689, CH3, CH3, H, F, Η), (M-11690, CHa, CHa, H, F, Cl), (M-11691, CHa, CHa, H, F, F), (M-11692, CHa, CHs, H, F, CF3), (M-11693, CH3, CH3, H, F, Br), (M-11694, CH3, CH3, H, F, CH3), (M-11G95, CH3, CH3, H, Cl, Η), (M-11696, CH3, CH3, H, Cl, Cl), (M-11697, CH3, CH3, H，Cl, F), (Μ·11698, CH3, CH3, H, Cl, CF3), (M-11699, CH3, CH3, H, Cl，Br), (M-11700, CH3, CH3, H, Cl, CH3), (M-11701, CH3, CH3, H, CH3, Η), (M-11702, CH3, CH3, H, CH3, Cl), (M-11703, CH3, CH3, H, CH3, F), (M-11704, CHa, CH3, H, CHa，GF3)， (M-11705, CH3, CH3, H, CH3, Br), (M-11706, CH3, CH3, H, CH3, CH3)，（M-11707, CHs, CHs, H, Et, Η), (M-11708, CHs, CH3, H, Et, Cl), (M-11709, CH3, CHs, H, Et, F), (M-11710, CHa, CHs, H, Et, CFa), (M-11711, CHa, CHs, H, Et, Br), (M-11712, CHa, CHa, H, Et, CHa), (M-11713, CHa, CHa, H, n-Pr, Η), (M-11714, CH3, CH3, H, n-Pr, Cl), (M-11715, CH3, CHs, H, n-Pr, F), (M-11716, CHa, CHa, H, n-Pr, _________________ 293 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） --------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五、發明說明（巧> ) (請先閱讀背面之注咅？事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 CFa), (M-11717, CH3, CHs, H, n-Pr, Br), (M-11718, CHs, CH3, H, n-Pr, CHs), (M-11719, CH3, CHs, H, c-Pr, Η), (M-11720, CH3, CHa, H, c-Pr, Cl), (M-11721, CH3, CH3, H, c-Pr, F), (M-11722, CHs, CH3, H, c-Pr, CF3), (M-11723, CH3, CH3, H, c-Pr, Br), (M.11724, Gila, Clin, 11, c-Pr, Clin), (M-11725, Clin, ΟΠη. H, i-Pr, Η), (M-11726, CH3, CH3, H, i-Pr, Cl), (M-11727, CH3, CH3, H, i-Pr, F), (Μ·11728, CHa, CHa, H, i-Pr, CFa), (M-11729, CHa, CHs, H, i-Pr, Br), (M-11730, CHa, CH3, H, i-Pr, CHa), (M-11731, CHa, CHa, H, n-Bu, Η), (M-11732, CHa, CH3, H, n-Bu, Cl), (M-11733, CHa, CH3, H, n-Bu, F), (M-11734, CHa, CH3, H, n-Bu, CFs), (M-11735, CHs, CHa, H, n-Bu, Br), (M-11736, CH3, CH3, H, n-Bu, GH3), (M-11737, CHa, CHa, H, i-Bu, Η), (M-11738, CHa, CHa, H, i-Bu, Cl), (M-11739, CHa, CH3, H, i-Bu, F), (M-11740, CHa, CHa, H, i-Bu, CFa), (M-11741, CH3, CHs, H, i-Bu, Br), (M-11742, CH3, CH3, H, i-Bu, CH3), (M-11743, CH3, CH3, H, sec-Bu， Η), (M-11744, CHs, CHs, H, sec-Bu, Cl), (M-11745, CH3, CHs, H, sec-Bu, F), (M-11746, CH3, CH3, H, sec-Bu, CF3), (M-11747, CH3, CH3, H, sec-Bu, Br), (M-11748, CH3, CH3, H, eec-Bu, CH3), (M-11749, CHa, CH3, H, n-Pen, Η), (M-11750, CH3, CH3, H, n-Pen, Cl), (M-11751, CH3, CH3, H, n-Pen, F), (M-11752, CH3, CHa, H, n-Pen, CFs), (M-11753, CHa, CH3, H, n-Pen, Br), (M-11754, CH3, CH3, H, n-Pen, CH3), (M-11755, CH3, CH3, H, c-Pen, Η), (M-11756, CH3, CHa, H c-Pen, Cl), (M-11757, CH3, CH3, H, c-Pen, F), (M-11758, CH3, CH3, H, c-Pen， CFa), (M-11759, CHa, CHs, H, c-Pen, Br), (M-11760, CHa, CHa, H, c-Pen. CHa), (M-11761, CHs, CHa, H, n-Hex, Η), (M-11762, CHa, CHa, H, n-Hex, Cl), (M-11763, CHa, CHa, H, n-Hex, F), (M-11764, CHa, CH3, H, n-Hex, CF3), (M-11765 CH3, CH3, H，n-Hex, Br), (M-11766, CH3, CH3, H, n-Hex, CH3), (M-117G7, CH3 CHa, H, c-Hex, Η), (M-11768, CHs, CHa, H, c-Hex, Cl), (M-11769, CH3, CH3, H c-Hex, F), (M-11770, CHs, CH3, H, c-Hex, CF3), (M-11771, GH3, CH3, H, c-Hex Br), (M-11772, CHa, CHs, H, c-Hex, CHa), (M-11773, CHa, CHs, H, OH, H), -----9S)A _ 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 1284639 A7 B7 五、發明說明（巧― 經濟部智慧財產局員工消費合作社印製 (M-11774, CHa, CHa, H, OH, Cl), (M-11775, CHa, CHa, H, OH, F), (M-11776, CH3, CHa, H, OH, CF3), (M-11777, CH3, CH3, H, OH, Br), (M-11778, CH3, CH3, H, OH, CHs), (M-11779, CHs, CHs, H, EtO, Η), (M-11780, CH3, CHs, H, EtO, Cl), (M-11781, CHa, Clhf H, EtO, F), (M-11782, Clin, CHn, II, IOtO, CFm), (M.U78a, CH3, CH3, H, EtO, Br), (M-11784, CH3, CH3, H, EtO, CH3), (M-11785, CH3, CH.3, H, n-PrO, Η), (M-11786, CHs, CHa, H, n-PrO, Cl), (M-11787, CHa, CHa, H, n-PrO, F), (M-11788, CHa, CH3, H, n-PrO, CF3), (M-11789, CHa, CHa, H, n-PrO, Br), (M-11790, CH3, CH3, H, n-PrO, CH3), (M-11791, CH3, CH3, H, PhO, H)， (M-11792, CH3, CH3, H, PhO, Cl), (M-11793, CH3, CH3, H, PhO, F), (M-11794, CHa, CH3, H, PhO, CF3)，（M-11795, CH3, CH3, H, PhO, Br), (M-11796, CH3, CH3, H, PhO, CHs), (M-11797, CHa, CHs, Η, BnO, Η), (M-11798, GH3, CHa, H, BnO, Cl), (M-11799, CHa, CHs, H, BnO, F), (M-11800, CHa, CHa, H, BnO, CFa), (M-11801, CHs, CH3, H, BnO, Br), (M-11802, CH3, CHs, H, BnO, CHa), (M-11803, CH3, CH3, H, PhCH2CH2〇, Η), (M-11804, CH3, CH3, H, PhCH2CH2〇, Cl), (M· 11805, CH3, CH3, H, PhCH2CH2〇, F), (M-11806, CH3, CH3, H, PhCH2CH2〇， CFa), (M-11807, CHs, CH3, H, PhCH2CH2〇, Br), (M-11808, CHa, CHa, H, PI1CH2CH2O, CH3), (M-11809, CH3, CH3, H, CF3〇, Η), (Μ·11810, CH3, CH3, H,| CF3〇, Cl), (M-11811, CH3, CH3, H, CF3〇, F), (Μ·11812, CH3, CH3, H，CF3〇, GFa), (M-11813, CH3, CHa, H, CFsO, Br), (M-11814, CH3, CHs, H, CFaO, CHa),! (M-11815, CHs, CHa, H, Ph, Η), (M-11816, CHa, CH3, H, Ph, Cl), (M-11817, CH3 CH3, H, Ph, F), (M-11818, CH3, CH3, H, Ph, CF3), (M-11819, CH3, CH3, H, Phj Br), (M-11820, CHs, CH3, H, Ph, CHa), (M-11821, CH3, CH3, H, 4-F-Ph, H), (M-11822, CHa, CHs, H, 4-F-Ph, Cl), (M-11823, CHa, CH3, H, 4-F-Ph, F), (M-11824, CH3, CH3, H, 4-F-Ph, CF3), (M-11825, CH3, CH3, H, 4-F-Ph, Br), (M· 11826, CHa, CHa, H, 4-F-Ph, CHa), (M-11827, CHa, CH3> H, 4.CF3.Ph, Η), (M-11828, CHa, CHs, H, 4-CF3-Ph, Cl), (M-11829, CHs, CHs, H, 4-CFs.Ph, F), (Mj 請 先 閱 讀 背 & 之 注 意 事 項 再 填 本 頁 4 訂 線 本紙張尺度適用中國國家標準(CNS)A4規格咖x 297公參 1284639 經濟部智慧財產局員工消費合作社印製 A7 — _ B7 -------- 五、發明說明（>?4) 11830, CHa, CHa, H, 4-CF3-Ph, CFa), (M-11831, CHa, CHa, H, 4-CF3-Ph, Br), (Μ·11832, CH3, CH3, H, 4-CF3-Ph, CH3), (M-11833, CH3, CH3, H，4-(Me)2N-Ph， Η), (M-11834, CH3, CHs, H, 4-(Me)2N.Ph, Cl), (M-11835, CHa, CHa, H, 4-(Me)2N^Phf F), (M-11836, CILi, ClUt II, 4-(Mo)aN-Ph, CFa), (M-11837f CHa, CHn, H, 4-(Me)2N-Ph, Br), (M-11838, CH3, CH3, H, 4-(Me)2N-Ph, CH3)，（M-11839, CH3, CH3, H, 4-〇H-Ph, Η), (M-11840, CH3, CH3, H, 4-OH-Ph，Cl)，（M-11841， CH3, CH3, H, 4-OH-Ph, F), (M-11842, CHa, CHa, H, 4-OH-Ph, CFa), (M-11843, CHa, CHa, H, 4-OH-Ph, Br), (M-11844, CHa, CH3, H, 4-OH-Ph, CHa), (M-11845, CHa, CHa, H, 3,4-di.F.Ph, Η), (M-11846, CHa, CHa, H, 3,4-di-F-Ph, Cl), (M-11847, CH3, CH3, H, 3,4-di-F-Ph, F), (M-11848, CH3, CH3, H, 3,4-di-F-Ph，CF3)， (M-11849, CH3, CH3, H, 3,4-di-F-Ph, Br), (M-11850, CH3, CH3, H, 3,4-di-F-Ph， CH3), (M-11851, CHa, CHa, H, 4-COOH-Ph, Η), (M-11852, CHa, CHa, H, 4-COOH-Ph, Cl), (M-11853, CH3, CH3, H, 4-COOH-Ph, F), (M-11854, CH3, CH3, H, 4-COOH-Ph, CF3), (M-11855, CH3, CH3, H, 4-COOH-Ph, Br), (M-11856, CH3, CHs, H, 4-COOH.Ph, CHa), (M-11857, CHs, CH3, Η, Bn, Η), (M-11858, CH3, CHa, H, Bn, Cl), (M-11859, CHa, CH3, H, Bn, F), (M-11860, CHs, CH3, H, Bn, CFa), (M-11861, CHa, CHa, H, Bn, Br), (M-11862, CHa, CHa, H, Bn, CHs), (M-11863, CHa, CHa, H, 4-F-Bn, Η), (M-11864, CHs, CHa, H, 4-F-Bn, Cl), (M-11865, CH3, CH3, H, 4-F-Bn，F), (M-11866, CH3, CH3, H, 4-F-Bn，CF3), (M-11867, CH3, CH3, H, 4-F-Bn, Br), (M-11868, CH3, CH3, H, 4-F-Bn, CH3), (M-118G9, CHs， CHa, H, 2-Py, Η), (M-11870, CHa, CHa, H, 2-Py, Cl), (M-11871, CHa, CHa, H, 2-Py, F), (M-11872, CH3, CH3, H, 2-Py, CF3), (M-11873, CH3, CH3, H, 2-Py，Br)， (M-11874, CH3, CH3, H, 2-Py, CH3), (M-11875, CHa, CH3, H，3-Py，Η), (M-11876, CH3, CH3, H, 3-Py, Cl), <Μ·11877, CH3, CH3, H, 3-Py，F)，（Μ·11878, CH3, CH3, H，3-Py, CF3), (M-11879, CH3, CH3, H, 3-Py, Br), (M-11880, CH3, CH3, H，3-Py， CHa), (M-11881, CHa, CHa, H, 4-Py, Η), (M-11882, CH3, CH3, H, 4-Py, Cl), _ 90« 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） --------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五、發明說明 (M-11883, CHs, CH3, H, 4-Py, F), (M-11884, CHa, CHa, H, 4-Py, CFa), (M-11885, CH3, CHa, H, 4-Py, Br), (M-11886, CHa, CHa, H, 4-Py, CHa), (M-11887, CHa, CH3, H, 2-Th, Η), (M-11888, CH3, CHs, H, 2-Th, Cl), (M-11889, CH3, CH3, H， 2-Th, F), (M-11890, CH3, CH3, H, 2-Th, CF3), (M-11891, CH3, CH3, H, 2-Th, Br)， (M-11892, CHs, CH3, H, 2-Th, CHa), (M-11893, CHa, CHa, 11, 3-Th, II), (M-11894, CHa, CHs, H, 3-Th, Cl), (M-11896, CHs, CHa, H, 3-Th, F), (M-11896, CH3, CH3, H, 3-Th, CF3), (M-11897, CH3, CH3, H，3-Th，Br), (M-11898, CH3, CH3, H，3-Th， CH3), (M-11899, CH3, CH3, H,吡唑-2-基，Η), (M-11900, CH3, CH3, H， 壯唑-2-基，Cl), (M-11901, CH3, CH3, H,吡唑-2-基，F), (M-11902, CH3， CH3, H,吡唑-2-基 > CF3), (M-11903, CH3, CH3, H,吡唑-2-基，Br)，（M-11904, CHs, CH3, H,吡唑-2-基，CH3), (M-11905, CH3, CH3, H，柏唑-3 -基 ,Η), (M-11906, CH3, CH3, H,吡唑-3_基，Cl), (M-11907, CHa, CH3, H， 壯唑 T3_基，F), (M-11908, CH3, CH3, H,吡唑-3-基，CFa), (M-11909, CH3, CH3, H,吡唑-3-基，Br), (M-11910, CH3, CH3, H,吡唑-3-基，CH3), (M· 11911, CHS, CH3, H,嘧啶-2-基，Η), (M.11912, CH3, CH3, H,嘧啶-2-基 ,Cl), (M-11913, CH3, CH3, H,嘧啶-2-基，F>, (M-11914, CH3, CH3, Η, 喃啶-2-基，CF3), (M-11915, CH3, CH3, H,啤啶-2-基；Br)，（M-11916, CH3, CH3, H,喃啶-2-基，CH3), (M-11917, CH3, CH3, Η, ϊ嘧啶-4-基，H)， (M-11918, CHs, CH3, H, i嘧啶-4-基，Cl), (M-11919, CH3, CH3, H, ]嘧啶-4-基，F), (M-11920, CH3, CH3, H,嘧啶-4·基.CF3), (M-11921， CH3, CH3, H,,嘧啶-4-基,Br), (M-11922, CH3，CH3, H,嘧啶-4-基，CH3)， (M-11923, CH3, CH3, H,嘧啶-5-基，Η), (Μ·11924, CH3, CH3, H, i嘧啶-5-基，,Cl), (M-11925, CH3, CH3, H，嘧啶-5-基，F), (M-11926, CH3, CH3, H,嘧啶-5-基，CF3), (M-11927, CH3, CH3, H,嘧啶-5·基，Br), (M-11928, CH3, CH3, H,嘧啶-5-基，CH3), (M-11929, CH3, CH3, H， HOOCCH2CH2CH2, Η), (M-11930, CHs, CHa, H, HOOCCH2CH2CH2, Cl), (M- 297 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事 本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、ίϋ3, ΐί, HOOCCH2CH2CH2, F), (M-11932, CH3, CH3, H， HOOCCH2CH2CH2, CFs), (M-11933, CHa, CHa, H, HOOCCH2CH2CH2, Br), (M-11934, CHs, CHs, H, HOOCCH2CH2CH2, CHa), (M-11936, CH3> CHa, H, HOOCCH2CH2CH2CH2, Η), (M-11936, CH3, CH3, H, HOOCCH2CH2CH2CH2, Cl), <Μ·11937, CHa, CH·% Π· IlOOCClhCIhCIhCIla, F), (Μ·11938, CUh, HOOCCH2CH2CH2CH2, CF3), (M-11939, CH3, CHa, H, HOOCCH2CH2CH2GH2, Br), (M-11940, CHs, CH3, H, HOOCCH2CH2CH2CH2, CHa), (M-11941, CHs, CH3, H, (Me)2NCOCH2CH2CH2CH2, Η), (M-11942, CH3, CH3, H, (Me)2NCOCH2CH2CH2CH2, Cl), (M-11943, CH3, CH3, H， (Me)2NCOCH2CH2CH2CH2, F), (M-11944, CH3, CH3, H， (Me)2NCOCH2CH2CH2CH2, CF3), (M· 11945, CH3, CH3, H, (Me)2NCOCH2CH2CH2CH2, Br), (M-11946, CH3, CH3, H, (Me)2NCOCH2CH2CH2CH2, CH3), (M-11947, CH3, CH3, H, (Me>2NCOCH2CH2CH2CH2CH2, Η), (M-11948, CH3, CH3, H, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-11949, CH3, CH3, H, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-11950, CH3, CH3, H, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-11951, CH3, CH3, H, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-11952, CH3, CH3, H, (Me)2NCOCH2CH2CH2CH2CH2, CHs), (M-11953, CHa, CHa, H, MeOCHa, H), (M-11954, CH3, CH3, H, MeOCH2, Cl), (M-11955, CH3, CH3, H, MeOCH2, F), (M-11956, CHa, CHs, H, MeOCH2, CFa), (M-11967, CHa, CHs, H, MeOCH2, Br), (M-11958, CH3, CH3, H, MeOCH2, CH3), (M-11959, CH3, CH3, H, EtOCH2, H)， (M-11960, CH3, CH3, H, EtOCH2, Cl), (M-11961, CH3, CH3, H, EtOCH2, F)， (M-11962, CH3, CH3, H, EtOCH2, CF3), (M-11963, CH3, CH3, H，EtOCH2, Br)， (M-11964, CH3, CH3, H, EtOCH2, CH3), (M-11965, CH3, CH3, H, EtOCH2CH2, Η), (M-11966, CH3, CH3, H, EtOCH2CH2, Cl), (M-11967, CH3, CH3, H， 298 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 請 先 閱 讀 背 之 注 項 箱 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 >^7 五 (ΜΛΐ968, CH3, CH3, H, EtOCH2CH2, CF3), (M-11969, CH3， 經濟部智慧財產局員工消費合作社印製 (請先閱讀背面之注意事項寫本頁) CH3, H, EtOCH2CH2, Br), (M-11970, CH3, CH3, H, EtOCH2CH2, CH3), (M· 11971, CH3, CH3, H, MeOCH2CH2〇CH2CH2, Η), (M-11972, CH3, CH3, H， MeOCH2CH2〇CH2CH2, Cl), (M-11973, CH3, CHa, H, MeOCH2CH2〇CH2CH2, F), (M-11974, CHa, CH3, H, MeOClhCmOCHaCIh, CFa)· (Μ·115)7β· CRn, CHa、U· MeOCH2CH2〇CH2CH2, Br), (M-11976, CH3, CHa, H, MeOCIhClhOClhClIz, CH3), (M-11977, CH3, CH3, H, MeOCH2CH2, Η), (M-11978, CH3, CH3, H, MeOCH2CH2, Cl), (M-11979, CH3, CH3, H, MeOCH2CH2, F)，（M-11980, CH3, CH3, H, MeOCH2CH2, CF3), (M-11981, CH3, CH3, H, MeOCH2CH2, Br)，（M· 11982, CHa, CHa, H, MeOCH2CH2, CH3), (M-11983, CHa, CHs, H, HOCH2, H), (M-11984, CH3, CH3, H, HOCH2, Cl), (M-11985, CH3, CH3, H, HOCH2, F)，（M-11986, CHa, CHs, H, HOCH2, CFs), (M-11987, CHa, CHa, H, HOCH2, Br), (M-11988, CHa, CHa, H, HOCH2, CHa), (M-11989, CHa, CHa, H, HOCH2CH2. H), (M-11990, CHs, CHa, H, HOCH2CH2, Cl), (M-11991, CHa, CHa, H, HOCH2CH2, F), (M-11992, CHs, CHa, H, HOCH2CH2, CFa), (M-11993, CHa, CHa, H, HOCH2CH2, Br), (M-11994, CHa, CHa, H, HOCH2CH2, CH3), (M-11995, CH3, CHs, H, HOCH2CH2CH2, Η), (M-11996, CHa, CHa, H, HOCH2CH2CH2, Cl), (M-11997, CHs, CHa, H, HOCH2CH2CH2, F), (M-11998, CHa, CHa, H, HOCH2CH2CH2, CFs), (M-11999, CHa, CH3, H, HOCH2CH2CH2, Br), (M-12000, CHa, CHs, H, HOCH2CH2CH2, CHs), (M-12001, CH3, CHa, H, HOCH2CH2CH2CH2, Η), (M-12002, CH3, CH3, H, HOCH2CH2CH2CH2, Cl)，（M· 12003, CHs, CH3, H, HOCH2CH2CH2CH2, F), (M-12004, CHa, CHa, H, HOCH2CH2CH2CH2, CFa), (M-12005, CHa, CHa, H, HOCH2CH2CH2CH2, Br), (M-12006, CHa, CHs, H, HOCH2CH2CH2CH2, CHa), (M-12007, CHa, CHs, H, HOCH2CH2CH2CH2CH2, Η), (M-12008, CHa, CHs, H, HOCH2CH2CH2CH2CH2, Cl), (M-12009, CH3, CHa, H, HOCH2CH2CH2CH2CH2, F), (M-12010, CH3, CH3, 299 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 2CH2, CF3), (M-12011, ch3, ch3, h, HOCH2CH2CH2CH2CH2, Br), (M-12012, CHa, CHa, H, HOCH2CH2CH2CH2CH2, CHa), (M-12013, CHs, CH3, H, HOCH2CH2OCH2CH2, Η), (M-12014, CH3, CH3, H, HOCH2CH2OCH2CH2, Cl), (M-12015, CHa, CHs, H, HOCH2CH2OCH2CH2, F), (M-12016, CHs, CHs, H, HOCIUCIUOCIUCU^ CPa), (M-12017, Clla, OUa, Π, HOCH2CH2OCH2CH2, Br), (M-12018, CHs, CHa, H, HOCH2CH2OCH2CH2, CHs), (M-12019, CH3, CH3, H, (Me)2N, Η), (M-12020, CHa, CH3, H，（Me)2N, Cl), (M· 12021, CH3, CH3, H, (Me)2N, F), (M-12022, CH3, CH3, H, (Me)2N, CF3)，（M· 12023, CH3, CH3, H, (Me)2N, Br), (M-12024, CH3, CH3, H, (Me)2N, CH3), (M-12025, CH3, CH3, H,哌啶·4·基甲基，Η), (M-12026, CH3, CH3, H, 哌啶-4-基甲基丨，Cl), (M-12027, CH3, CH3, H,哌啶-4_基甲棊，F), (M-12028, CH3, CH3, H,哌啶-4-基甲基，CF3), (M-12029, CH3, CH3, H， 哌啶-4-基甲基,Br),.(M-12030, CH3, CH3, H,哌啶-4-基甲基， CH3), (M-12031, CH3, CH3, H,環己基甲基t, Η), (M-12032, CH3, CH3, H， 環己基甲基，Cl), (M-12033, CH3, CH3, H,環己基甲基，F), (M-12034, CH3, CH3, H,環己基甲基,CF3), (M-12035, CH3, CH3, H, 環己基甲基，Br), (Μ·12〇36, CHS, CH3, H,環己基甲基，（：113),(]^-12037, CH3, CH3, F, Η, H)，（M-12038, CH3, CH3, F, H，Cl), (M-12039, CH3, CH3, F, H, F), (M-12040, CHa, CHa, F, H, CFa), (M-12041, CHa, CHa, F, H, Br), (M-12042, CH3, CH3, F, H，CH3), (M-12043, CH3, CH3, F, F, H)，（M-12044, CH3， CH3, F, F, Cl), (M-12045, CH3, CH3, F, F, F), (M-12046, CH3, CH3, F, F, CF3)， (M-12047, CH3, CH3, F, F, Br), (M-12048, CH3, CH3, F, F, CH3), (M-12049, CH3, CHa, F, Cl, Η), (M-12050, CH3, CH3, F, Cl, Cl), (M-12051，CH3, CH3, F，Cl，F), (M-12052, CH3, CH3, F, Cl, CF3), (M-12053, CH3, CH3, F, Cl, Br), (M-12054， CH3, CH3, F, Cl, CH3), (M-12055, CH3, CH3, F, CH3, Η), (M-12056, CH3, CH3, F， CHa, Cl), (M-12057, CHa, CHs, F, CHa, F), (M-12058, CH3, CHa, F, CH3, CFa), 300 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） (請先閱讀背面之注意事 本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五(k背2锻IMfi3,(CH3>, CH3, Br), (M-12060, CH3, CH3, F, CH3, CH3), (Μ·12061， CH3, CH3, F, Et, Η), (M-12062, CH3, CH3, F, Et, Cl), (M-12063, CH3, CH3, F, Et， F), (M-12064, CHa, CH3, F, Et, CFs), (M-12065, CHa, CHa, F, Et, Br), (M-12066, CH3, CH3, F, Et, CH3), (M-12067, CH3, CH3, F, n-Pr, Η), (M-12068, CH3, CH3, F, n-Pr, Ci), (M-12069, ClUt ClUt F, n-Pr, F), (M-12070, Glia, Clla, F, n-Pr, 01^), (M-12071, CH3, CHa, F, n-Pr, Br), (M-12072, CHs, CHa, F, n-Pr, CHa), (M-12073, CHa, CHs, F, c-Pr, Η), (M-12074, CHa, CHa, F, c-Pr, Cl), (M-12075, CH3, CH3, F, c-Pr, F), (M-12076, CH3, CH3, F, c-Pr, CF3), (M-12077, CH3, CH3, F, c-Pr, Br), (M-12078, CH3, CH3, F, c-Pr, CH3), (M-12079, CH3, CH3, F, i-Pr, H)，（M-12080, CH3, CH3, F, i-Pr, Cl), (M-12081, CH3, CH3, F, i-Pr, F), (M-12082, CH3, CH3, F， i-Pr, CFs), (M-12083, CHa, CHa, F, i-Pr, Br), (M-12084, CHa, CHa, F, i-Pr, CHs), (M-12085, CH3, CH3, F, n-Bu, Η), (M-12086, CH3, CH3, F, n-Bu, Cl), (Μ·12087, CH3, CH3, F, n-Bu, F), (M-12088, CH3, CH3, F, n-Bu，CF3), (M-12089, CH& CHa, F, n-Bu, Br), (M-12090, CH3, CH3, F, n-Bu, CH3), (M-12091, CH3, CH3, F，i-Bu， Η), (M-12092, CHs, CHa, F, i-Bu, Cl), (M-12093, CHa, CHa, F, i-Bu, F), (M-12094, CHa, CHa, F, i-Bu, CF3), (M-12095, CHa, CHa, F, i-Bu, Br), (M-12096, CHa, CHa, F, i-Bu, CHa), (M-12097, CH3, CHa, F, sec-Bu, Η), (M-12098, CHs, CH3, F, sec_Bu, Cl), (M-12099, CH3, CH3, F, sec-Bu，F), (M-12100, CH3, CH3, F， sec-Bu, CF3), (M-12101, CH3, CHa, F, sec-Bu, Br), (M-12102, CHa, CH3> F， sec-Bu, CH3), (M-12103, CH3, CH3, F, n-Pen, Η), (M-12104, CH3, CH3, F，n-Pen， Cl), (M-12105, CHa, CHs, F, n-Pen, F), (M-12106, CH3, CHa, F, n-Pen, CFs), (M-12107, CH3, CH3, F, n-Pen, Br), (M-12108, CH3, CH3, F, n-Pen, CH3), (M-12109, CH3, CH3, F, c-Pen, Η), (M-12110, CH3, CH3, F, c-Pen, Cl), (M-12111, CHa, CHs, F, c-Pen, F), (M-12112, CH3, CHa, F, c-Pen, CFa), (M-12113, CHa, CH3, F, c-Pen, Br), (M-12114, CH3, CH3, F, c-Pen, CHa), (M-12115, CH3, CH3, F, n-Hex, Η), (M-12116, CH3, CH3, F, n-Hex, Cl), (M-12117, CH3, CH3, F，n-Hex, 301 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事 本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、發明說明pw) F), (M-12118, CH3, CH3, F, n-Hex, CF3), (M-12119, CH3, CH3, F, n-Hex, Br), (M-12120, CHa, CHs, F, n-Hex, CHa), (M-12121, CHa, CHa, F, c-Hex, Η), (M-12122, CHa, CH3, F, c-Hex, Cl), (M-12123, CH3, CH3, F，c-Hex, F), (M-12124, CHa, CHa, F, c-Hex, CFa), (M-12125, CHs, CHa, F, c-Hex, Br), (M-12126, CHs, CHa, F, c-Hex, CHa), (M-12127, Clla, CHa, F, Oil, Η). (M-12128, Clla, C\ht K, OH, Cl), (M-12129, CHs, CH3, F, OH, F), (M-12130, CH3, CH3, F, OH, CF3)， (M-12131, CH3, CH3, F, OH, Br), (M-12132, CH3, CH3, F, OH, CHs)，（M-12133, CH3, CH3, F, EtO, H)，（M-12134, CH3, CH3, F, EtO, Cl), (M-12135, CH3, CH3, F, EtO, F), (M-12136, CHa, CH3, F, EtO, CFs), (M-12137, CHa, CHs, F, EtO, Br), (M-12138, CHs, CH3, F, EtO, CHa), (M-12139, CHa, CH3, F, n-PrO, Η), (M-12140, CH3, CH3, F, n-PrO, Cl), (M-12141, CH3, CH3, F, n-PrO, F), (Μ·12142· CH3, CH3, F, n-PrO, CF3), (M-12143, CH3, CH3, F, n-PrO, Br), (M-12144, CH3, CH3, F, n-PrO, CH3), (M-12145, CH3, CH3, F, PhO, H)，（M-12146, CH3, CH3、F、 PhO, Cl), (M-12147, CH3, CH3, F, PhO, F), (M-12148, CH3, CH3, F, PhO, CF3)， (M-12149, CHs, CHs, F, PhO, Br), (M-12150, CHa, CHs, F, PhO, CHs), (M-12151, CH3, CH3, F, BnO, Η), (M-12152, CH3, CH3, F, BnO, Cl), (M-12153, CH3, CH3, F， BnO, F), (M-12154, CH3, CH3, F, BnO, CF3), (M-12155, CH3, CH3, F，BnO, Br)， (M-12156, CH3, CH3, F, BnO, CH3), (M-12157, CH3, CH3, F, PhCH2CH2〇, H)， (M-12158, CH3, CH3, F, PhCH2CH2〇, Cl), (M-12159, CH3, CH3, F, PhCH2CH2〇, F), (M-12160, CH3, CH3, F, PI1CH2CH2O, CF3), (M-12161, CH3, CH3, F, PhCH2CH2〇, Br), (M-12162, CH3, CH3, F, PhCH2CH2〇, CH3), (M-12163, CH3, CH3, F, CF3〇, Η), (M-12164, CH3, CH3, F, CF3〇, Cl), (M-12165, CH3, CH3, F， CF3〇, F), (M-12166, CH3, CH3, F, CF3〇, CF3), (M-12167, CH3, CH3, F，CF3〇， Br), (M-12168, CHs, CHs, F, CFaO, CH3), (M-12169, CHa, CHa, F, Ph, Η), (M-12170, CH3, CH3, F, Ph, Cl), (M-12171, CH3, CH3, F, Ph, F), (M-12172, CH3， CH3, F, Ph, CF3), (M-12173, CH3, CH3, F, Ph, Br), (M-12174, CH3, CH3, F，Ph， 302 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 閱 讀 背 面 之 注 意 事 項 f 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五 ch3〉, CH3, F, 4-F-Ph, H), (M-12176, CH3, CH3, F, 4-F-Ph, Cl), (請先閱讀背面之注意事項本頁) (M-12177, CHs, CHs, F, 4-F-Ph, F), (M-12178, CHa, CHa, F, 4-F-Ph, CFa), (M-12179, CH3, CHs, F, 4-F-Ph, Br), (M-12180, CHa, CHa, F, 4-F-Ph, CH3), (M-12181,CH3,CH3,F,4-CF3-Ph,H),(M-12182,CH3,CH3,F,4-CF3-Ph,Cl),(M-12183, CHa, CH3, F, 4-CFVPh, F)· (Μ·12184, C!lh, F, 4.C!Fa.l、h· C!Ka>， 經濟部智慧財產局員工消費合作社印製 (M-12185, CH3, CH3, F, 4-CF3-P1i, Br), (M-12186, CH3, CH3, F, 4-CF3-Ph, CH3), (M-12187, CH3, CH3, F, 4-(Me)2N-Ph, Η), (M-12188, CH3, CH3, F, 4-(Me)2N-Ph, Cl),(M-12189,CH3,CH3,F,4-(Me)2N-Ph,F),(M-12190,CH3,CH3，F，4· (Me)2N-Ph, CF3), (M-12191, CH3, CH3, F, 4-(Me)2N-Ph, Br), (M-12192, CH3， CH3, F, 4-(Me)2N-Ph, CH3), (M-12193, CH3, CH3, F, 4-OH-Ph, H)，（M-12194， CHa, CHa, F, 4-OH-Ph, Cl), (M-12195, CHa, CHa, F, 4-OH-Ph, F), (M-12196, CH3, CH3, F, 4-OH-Ph, CF3), (M-12197, CH3, CH3, F, 4-OH-Ph, Br), (M-12198, CHs, CH3, F, 4-OH-Ph, CH3), (M-12199, CH3, CH3, F, 3,4-di-F-Ph, H)，（M-12200· CHa, CHs, F, 3,4-di-F-Ph, Cl), (M-12201, CH3, CHa, F, 3,4-di-F-Ph, F), (M-12202, CHa, CH3, F, 3,4-di-F-Ph, CF3), (M-12203, CH3, CH3, F, 3,4-di-F-Ph，Br)， (M-12204, CH3, CH3, F, 3,4-di-F-Ph, CH3), (M-12205, CH3, CH3, F, 4-COOH-Ph， H),(M-12206,CH3,CH3,F,4-COOH-Ph,Cl),(M-12207,CH3，CH3，F，4· COOH-Ph, F), (M-12208, CH3, CH3, F, 4-COOH-Ph, CFs), (M-12209, CH3, CH3, F, 4-COOH-Ph, Br), (M-12210, CH3, CH3, F, 4-COOH-Ph, CH3), (M-12211，CHs， CH3, F, Bn, Η), (M-12212, CH3, CH3, F, Bn, Cl), (M-12213, CH3, CH3, F, Bn，F)， (M-12214, CHa, GHa, F, Bn, CFs), (M-12215, CHa, CHs, F, Bn, Br), (M-12216, CH3, CH3, F, Bn, CH3), (M-12217, CH3, CH3, F, 4-F-Bn, Η), (M-12218· CH3, CH3, F, 4-F-Bn, Cl), (M-12219, CH3, CH3, F, 4-F-Bn, F), (M-12220, CH3, CH3, F，4· F-Bn, CFa), (M-12221, CH3, CHa, F, 4-F-Bn, Br), (M-12222, CHa, CHa, F, 4-F-Bn, CH3), (M-12223, CH3, CH3, F, 2-Py, Η), (M-12224, CH3, CH3, F, 2-Py, Cl), (M-12225, CH3, CH3, F, 2-Py, F), (M-12226, CH3, CH3, F, 2-Py, CF3)，（M-12227, 303 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 ^CHaf^Ha^^.Py^Br^ CHs, CHa, F, 2-Py, CHs), (M-12229, CH3, CH3, F, 3-Py, Η), (M-12230, CH3, CH3, F, 3-Py, Cl), (M-12231, CH3, CH3, F, 3-Py, F)， (M-12232, CH3, CH3, F, 3-Py, CF3>, (M-12233, CH3, CH3, F, 3-Py, Br)，（M-12234, CHa, CHa, F, 3-Py, CHs), (M-12235, CHa, CH3, F, 4-Py, Η), (M-12236, CH3, CHs, F, 4-Py, Cl>, (M-12237, CH·% Clla, F, 4.Py, (M-12238, Gila, C!lh· K· 4.l、y, CF3), (M-12239, CH3, CH3, F, 4-Py, Br), (M· 12240, CH3, CH3, F, 4-Py, CHa), (M-12241, CH3, CH3, F, 2-Th, Η), (M-12242, CH3, CH3, F, 2-Th, Cl)，（M-12243, CH3, CH3, F, 2-Th，F), (M-12244, CH3, CH3, F, 2-Th, CF3), (M-12245, CH3, CH3, F, 2-Th, Br), (M-12246, CH3, CHa, F, 2-Th, CHa), (M-12247, CHa, CHa, F, 3-Th, Η), (M-12248, CH3, CHa, F, 3-Th, Cl), (M-12249, CHa, CH3, F, 3-Th, F), (M-12250, CH3, CH3, F, 3-Th, CF3), (M-12251, CH3, CH3, F, 3-Th, Br), (Μ·12252， CH3, CH3, F, 3-Th, CH3), (M-12253, CH3, CH3, F,吡唑-2-基，Η), (M-12254, CH3, CH3, F,吡唑-2-基，Cl), (M-12255, CH3, CH3, F,吡唑-2-基，F)，（M-12256, CH3, CH3, F,吡唑-2-基:,CF3), (M-12257, CH3, CH3, F,吡唑-2-基， Br), (M-12258, CH3, CHa, F,败唑-2-基 t CHa), (M-12259, CH3, CH3, F, 壯唑-3-基，Η), (M-12260, CH3, CH3, F,吡唑-3-基，Cl), (M-12261, CH3， CHa, F, Pft ^ - 3 - * i, F), (M-12262, CHa, CHa, F,吡唑-3 -基，CF3), (M-12263, CH3, CH3, F,吡唑-3·棊，Br), (M-12264, CH3, CH3, F,吡唑-3-基，CH3), (M-12265, CH3, CH3, F,嘧啶-2-基，Η), (M-12266, CH3, CH3, F， 嘧啶-2-基，Cl), (M-12267, CH3, CH3, F,嘧啶-2-基，F), (M-12268, CH3, CH3, F,嘧啶-2-基，CF3), (M-12269, CH3, CH3, F,嘧啶-2-基。Br), (M· 12270, CH3, CH3, F,嘧啶-2-基，CH3), (M-12271, CH3, CH3, F,嘧啶-4-基 1, Η), (M-12272, CH3, CH3, F,嘧啶-4-基，Cl), (M-12273, CH3, CH3, F, 嘧啶-4-基，F), (M-12274, CH3, CH3, F,嘧啶-4-基，CF3), (M-12275， CH3, CH3, F,嘧啶-4-基，Br), (M-12276, CH3, CH3, F,嘧啶-4_ 基，CH3), (M-12277, CH3, CH3, F，嘧啶-5_ 基,H)，（M-12278, CH3, CH3, F, 304 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項 阿本頁) 言·. 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、發明規用 嘧啶-5-基，bl), (ώ-12279, CH3, CH3, F,嘧啶-5-基，F)，（M-12280, CH3, CH3, F,嘧啶-5·基，CF3), (Μ·12281, CH3, CH3, F, p嘧啶-5-棊 1, Br)，（Μ· 12282, CH3, CH3, F,嘧啶-5-基，CH3), (M-l2283, CH3, CH3, F, HOOCCH2CH2CH2, Η), (M-12284, CHs, CHa, F, HOOCCH2CH2CH2, Cl), (M-12286, CH3, CIU, F, HOOCCIt2CnaClh, F)· (M· 1228(1, (Mta· CUla, K, HOOCCH2CH2CH2, CFa), (M-12287, CHs, CH3, F, HOOCCH2CH2CH2, Br), (M-12288, CHs, CHs, F, HOOCCH2CH2CH2, CHa), (M-12289, CHa, CHa, F, HOOCCH2CH2CH2CH2, Η), (M-12290, CHa, CHs, F, HOOCCH2CH2CH2CH2, Cl), (M-12291, CHa, CHs, F, HOOCCH2CH2CH2CH2, F), (M-12292, CH3, CH3, F, HOOCCH2CH2CH2CH2, CFa), (M-12293, CH3, CHa, F, HOOCCH2CH2CH2CH2, Br), (M-12294, CHs, CH3, F, HOOCCH2CH2CH2CH2, CHs), (M-12295, CHa, CH3. F, (Me)2NCOCH2CH2CH2CH2, Η), (M-12296, CH3, CHa, F, (Me)2NCOCH2CH2CH2CH2, Cl), (M-12297, CH3, CH3, F, (Me>2NCOCH2CH2CH2CH2, F), (M-12298, CH3, CH3, F, (Me)2NCOCH2CH2CH2CH2, CF3), (M-12299, CH3, CH3, F, (Me)2NCOCH2CH2CH2CH2, Br), (M-12300, CH3, CH3, F, (Me)2NCOCH2CH2CH2CH2, CH3), (M-12301, CH3, CH3, F, (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-12302, CH3, CH3, F, (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-12303, CH3, CH3, F, (Me)2NCOCH2CH2CH2CH2CH2, F), (M-12304, CH3, CH3, F, (Me)2NCOCH2CH2CH2CH2CH2, CF3), (M-12305, CH3, CH3, F, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-12306, CH3, CH3, F, (Me)2NCOCH2CH2CH2CH2CH2, CH3), (M-12307, CH3, CH3, F, MeOCH2, H)， (M-12308, CH3, CH3, F, MeOCH2, Cl), (M-12309, CH3, CH3, F, MeOCH2, F), (M-12310, CHa, CHa, F, MeOCH2, CFs), (M-12311, CHa, CHa, F, MeOCHs, Br), (M-12312, CH3, CH3, F, MeOCH2, CH3), (M-12313, CH3, CH3, F, EtOCH2, H)， 305 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ' ' (請先閱讀背面之注音？事項 本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五(沐日娜 3f CH3?F, EtOCH2, Cl), (M-12315, CHa, CHa, F, EtOCH2, F), (M-12316, CHs, CHs, F, EtOCH2, CFa), (M-12317, CH3, CHa, F, EtOCH2, Br), (M-12318, CH3, CH3, F, EtOCH2, CH3), (M-12319, CH3, CH3, F, EtOCH2CH2, H)， (M-12320, CH3, CH3, F, EtOCH2CH2, Cl), (M-12321, CH3, CH3, F, EtOCH2CH2, F), (M-12322, CHa, CIIs, F, EtOCUaCHa, GFa), (M-1232；}, 011^ Clh% F, EtOCH2CH2, Br), (M-12324, CHs, CHs, F, EtOCH2CH2, CHa), (M-12325, CH3, CH3, F, MeOCH2CH2〇CH2CH2, Η), (M-12326, CH3, CH3, F, MeOCH2CH2〇CH2CH2, Cl), (M-12327, CH3, CH3, F, MeOCH2CH2〇CH2CH2, F)， (M-12328, CH3, CH3, F, MeOCH2CH2〇CH2CH2, CF3), (M-12329, CH3, CH3, F， MeOCH2CH2OCH2CH2, Br), (M-12330, CH3, CH3, F, MeOCH2CH2〇CH2CH2， CH3), (M-12331, CH3, CH3, F, MeOCH2CH2, Η), (M-12332, CH3, CH3, F, MeOCH2CH2, Cl), (M-12333, CHs, CHa, F, MeOCH2CH2, F), (M-12334, CHa, CH3, F, MeOCH2CH2, CF3), (M-12335, CH3, CH3, F, MeOCH2CH2, Br), (M-12336, CHa, CHa, F, MeOCH2CH2, CHa), (M-12337, CHa, CHa, F, HOCH2, H), (M-12338, CH3, CHs, F, HOCH2, Cl), (M-12339, CHa, CHs, F, HOCH2, F), (M-12340, CH3, CHs, F, HOCH2, CFs), (M-12341, CHa, CHa, F, HOCH2, Br), (M-12342, CHa, CHa, F, HOCH2, CHa), (M-12343, CH3, CH3, F, HOCH2CH2, H), (M-12344, CHa, CHs, F, HOCH2CH2, Cl), (M-12345, CH3, CHs, F, HOCH2CH2, F), (M-12346, CH3, CHs, F, HOCH2CH2, CF3), (M-12347, CHa, CHs, F, HOCH2CH2, Br), (M-12348, CHa, CHs, F, HOCH2CH2, CHa), (M-12349, CHs, CHs, F, HOCH2CH2CH2, H), (M-12360, CHa, CH3, F, HOCH2CH2CH2, Cl), (M-12351, CH3, CH3, F, HOCH2CH2CH2, F), (M-12352, CH3, CH3, F, HOCH2CH2CH2, CFs), (M-12353, CHs, CHa, F, HOCH2CH2CH2, Br), (M-12354, CHa, CHs, F, HOCH2CH2CH2, CHa), (M-12355, CHa, CHa, F, HOCH2CH2CH2CH2, Η), (M-12356, CHs, CHa, F, HOCH2CH2CH2CH2, Cl), (M-12357, CH3, CHs, F, HOCH2CH2CH2CH2, F), (M-12358, CH3, CH3, F, 306 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項 本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、CF3), (Μ· 12359, CH3, CH3, F, HOCH2CH2CH2CH2, Br), (M-12360, CHs, CHs, F, HOCH2CH2CH2CH2, CHa), (M-12361, CHa, CH3, F, HOCH2CH2CH2CH2CH2, Η), (M-12362, CHa, CHS, F, HOCH2CH2CH2CH2CH2, Cl), (M-12363, CHs, CHs, F, HOCH2CH2CH2CH2CH2, F), (M-12364, CHs, CHa, F, HOCH2CH2CH2CH2CII2, CFa), (M-12365, CUa, Gila, F, nOClIaCUaCtbCIhOHs, Br), (M-12366, CHa, CHs, F, HOCH2CH2CH2CH2CH2, CHs), (M-12367, CH3, CHa, F, HOCH2CH2OCH2CH2, Η), (M-12368, CHa, CHa, F, HOCH2CH2OCH2CH2, Cl), (M-12369, CHa, CHs, F, HOCH2CH2OCH2CH2, F), (M-12370, CHs, CHa, F, HOCH2CH2OCH2CH2, CFs), (M-12371, CHs, CHs, F, HOCH2CH2OCH2CH2, Br), (M-12372, CHa, CH3, F, HOCH2CH2OCH2CH2, CH3)， (M-12373, CH3, CH3, F, (Me)2N, Η), (M-12374, CH3, CH3, F, (Me)2N，Cl)，（M· 12375, CHa, CHs, F, (Me)2N, F), (M-12376, CH3, CHa, F, (Me)2N, CF3), (M-12377, CH3, CHa, F, (Me)2N, Br), (M-12378, CH3, CH3, F, (Me)2N, CH3)，（M· 12379, CH3, CH3, F,哌啶-4-基甲基;Η), (M-12380, CH3, CH3, F, 哌啶-4 -基甲基丨，Cl), (Μ·12381, CH3, CH3, F,韻啶-4 ·基甲基，F)， (M-12382, CH3, CH3, F,哌啶-4-基甲棊> CF3), (Μ·12383, CH3, CH3, F， 哌啶-4-基甲基丨，Br), (Μ·12384, CH3, CH3, F,哌啶-4-基甲棊， CH3), (M-12385, CH3, CH3, F,環己基甲基，Η), (M-12386, CH3, CH3, F, 環己基甲基丨,Cl), (M-12387, CH3, CH3, F,環己基甲基，F), (M-12388, CH3, CH3,F,環己基甲棊，CF3), (M-12389, CH3,CH3,F,環己基甲基， Br), (M-12390, GH3, CH3, F,環己基甲基 I, CH3), (M-12391，CH3, Clh，Cl, Η, Η), (M-12392, CH3, CH3, Cl, H, Cl), (M-12393, CH3, CH3, Cl, H，F), (M-12394· CH3, CH3, Cl, H, CF3), (M-12395, CH3, CH3, Cl, H, Br), (M-12396, CH3, CH3, Cl， H, CHs), (M-12397, CHs, CH3, Cl, F, Η), (M-12398, CHa, CHa, Cl, F, Cl), (M-12399, CH3, CH3, Cl, F, F>, (M-12400, CH3, CH3, Cl, F, CF3), (M-12401, CH3， CH3, Cl, F, Br), (M-12402, CH3, CH3, Cl, F, CH3), (M-12403, CH3, CH3, Cl，Cl， 307 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） (請先閱讀背面之注意事項 本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 五、發明說明 Η), (M-12404, CHs, CHa, Cl, Cl, Cl), (M-12405, CHa, CHa, Cl, Cl, F), (M-12406, CHa, CHa, Cl, Cl, CFs), (M-12407, CHs, CH3, Cl, Cl, Br), (M-12408, CHs, CHs, Cl, Cl, CH3), (M-12409, CH3, CH3, Cl, CH3, Η), (M-12410, CH3, CH3, Cl, CH3, Cl)， (Μ·12411, CH3, CH3, Cl, CH3, F), (M-12412, CH3, CH3, Cl，CH3, CF3), (M-12413, CH3, CHs, Cl, CHs, Br), (M-12414, Gila, Clia, Cl, CUa, CHji), (M.12415, CAhu CH3, Cl, Et, Η), (M-12416, CH3, CH3, Cl, Et, Cl), (M-12417, CHa, CHa, Cl, Et, F), (M-12418, CH3, CH3, Cl, Et, CF3), (M-12419, CH3, CH3, Cl, Et, Br)，（M-12420, CH3, CH3, Cl, Et, CHa), (M-12421, CH3, CH3, Cl, n-Pr, Η), (M-12422, CH3, CH3, Cl, n-Pr, Cl), (M-12423, CH3, CH3, Cl, n-Pr, F), (M-12424, CH3, CH3, Cl，n-Pr， CF3), (M-12425, CH3, CH3, Cl, n-Pr, Br), (M-12426, CH3, CH3, Cl，n-Pr，CH3)， (M-12427, CH3, CH3, Cl, c-Pr, Η), (Μ·12428, CH3, CH3, Cl，c-Pr, Cl), (M-12429, CHa, CHa, Cl, c-Pr, F), (M-12430, CHa, CHa, Cl, c-Pr, CFa), (M-12431, CHa, CHa, Cl, c-Pr, Br), (M-12432, CH3, CH3, Cl, c-Pr, CHa), (Μ·12433, CH3, CH3, Cl· i· Pr, Η), (M-12434, CH3, CH3, Cl, i-Pr, Cl), (M-12435, CH3, CH3, Cl, i-Pr，F), (M-12436, CHa, CH3, Cl, i-Pr, CF3), (M-12437, CH3, CH3, Cl, i-Pr，Br)，（M-12438, CHa, CHa, Cl, i-Pr, CHs), (M-12439, CHa, CHs, Cl, n-Bu, Η), (M-12440, CHa, CH3, Cl, n-Bu, Cl), (M-12441, CHa, CH3, Cl, n-Bu, F), (M-12442, CHa, CH3, Cl， n-Bu, CFa), (M-12443, CHa, CH3, Cl, n-Bu, Br), (M-12444, CH3, CHa, Cl, n-Bu, CH3), (M-12445, CH3, CH3, Cl, i-Bu, H>，（M-12446, CH3, CH3, Cl, i-Bu，Cl), (M-12447, CH3, CH3, Cl, i-Bu, F), (M-12448, CH3, CH3, Cl, i-Bu, CF3), (M-12449, CHa, CHs, Cl, i-Bu, Br), (M-12450, CHa, CHa, Cl, i-Bu, CHa), (M-12451, CHa, CHa, Cl, sec-Bu, Η), (M-12452, CHa, CHa, Cl, sec-Bu, Cl), (M-12453, CHa, CHs, Cl, sec-Bu, F), (M-12454, CHs, CH3, Cl, sec-Bu, CFa), (M-12455, CHs, CHa, Cl, sec-Bu, Br), (M-12456, CH3, CH3, Cl, sec-Bu, CH3), (M-12457, CH3, CH3, Cl， n-Peii, Η), (M-12458, CH3, CH3, Cl, n-Pen, Cl), (M-12459, CH3, CH3, Cl，n-Pen， F), (M-12460, CH3, CH3, Cl, n-Pen, CF3), (M-12461, CH3, CH3, Cl, n-Pen, Br), 308 本€張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ； (請先閱讀势面之注意事項v Γ本頁) 經濟部智慧財產局員工消費合作杜印製 1284639 A7 B7 五、發明說明（>"7) (M-12462, CHs, CHa, Cl, n-Pen, CHa), (M-12463, CHa, CHa, Cl, c-Pen, Η), (M-12464, CHa, CHs, Cl, c-Pen, Cl), (M-12466, CHa, CHa, Cl, c-Pen, F), (M-12466, CHa, CHa, Cl, c-Pen, CFs), (M-12467, CHa, CHa, Cl, c-Pen, Br), (M-12468, CHa, CHa, Cl, c-Pen, CHa), (M-12469, CHa, CHs, Cl, n-Hex, Η), (M-12470, CH3, CH3>
Cl, n-Hex，Cl), (M-12471，Cll·% CHa, Cl, η·Ηοχ, F), (M-12472, C〕lh· Clh、ΓΛ n-Hex, CFa), (M-12473, CHs, CHs, Cl, n-Hex, Br), (M-12474, CHa, CHa, Cl, n· Hex, CHs), (M-12475, CHa, CHa, Cl, c-Hex, Η), (M-12476, CHa, CHa, Cl, c-Hex, Cl), (M-12477, CH3, CH3, Cl, c-Hex, F), (M-12478, CH3, CH3, Cl, c-Hex，CF3)， (M-12479, CHs, CHs, Cl, c-Hex, Br), (M-12480, CHs, CHa, Cl, c-Hex, CHa), (M-12481, CHa, CH3, Cl, OH, Η), (M-12482, CH3, CHa, Cl, OH, Cl), (M-12483, CHs, CHs, Cl, OH, F), (M-12484, CHa, CHa, Cl, OH, CFs), (M-12485, CHs, CHs, Cl, OH, Br), (M-12486, CH3, CH3, Cl, OH, CH3), (M-12487, CH3, CHa, Cl, EtO, Η), (M-12488, CH3, CH3, Cl, EtO, Cl), (M-12489,!CH3, CH3, Cl, EtO, F), (M-12490, CH3, CH3, Cl, EtO, CF3), (M-12491, CH3, CH3, Cl, EtO, Br), (M-12492, CH3, CH3, Cl, EtO, CH3), (M-12493, CH3, CH3, Cl, n-PrO, Η), (M-12494, CH3, CHs, Cl, n-PrO, Cl), (M-12495, CHs, CHa, Cl, n-PrO, F), (M-12496, CHa, CH3> Cl, n-PrO, CF3), (Μ·12497, CH3, CH3, Cl, n-PrO, Br), (M-12498, CH3, CH3, Cl, n-PrO, CHs), (M-12499, CHa, CHs, Cl, PhO, Η), (M-12500, CHa, CHa, Cl, PhO, Cl), (M-12501, CHa, CH3, Cl, PhO, F), (M-12602, CHa, CHa, Cl, PhO, CFa), (M-12503, CH3, CH3, Cl, PhO, Br), (M-12504, CH3, CH3, Cl, PhO, CH3), (M-12505, CH3， CH3, Cl, BnO, H); (M-12506, CHa, CHa, Cl, BnO, Cl), (M-12507, CHa, CHs, Cl, BnO, F), (M-12508, CHs, CH3, Cl, BnO, CF3), (M-12509, CH3, CHa, Cl, BnO, Br)， (M-12510, CH3, CH3, Cl, BnO, CH3), (M-12511, CH3, CH3, Cl, PhCH2CH2〇, H)， (M-12512, CH3, CH3, Cl, PhCH2CH2〇, Cl), (M-12513, CH3, CH3, Cl， PhCH2CH2〇, F), (M-12514, CH3, CH3, Cl, PhCH2CH2〇, CF3), (M-12515, CH3, ]H3, Cl, PhCH2CH2〇, Br), (M-12516, CH3, CH3, Cl, PhCH2CH2〇, CH3), (M- 309 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項 本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7
Cl, Jf3〇, Η), (M-12518, CH3, CH3, Cl, CF3〇, Cl), (M-12519, CH3, CH3, Cl, CF30, F), (M-12520, CH3, CH3, Cl, CF3〇, CF3), (M-12521，CHs， CHa, Cl, CFaO, Br), (M-12522, CHa, CHa, Cl, CFaO, CHa), (M-12523, CHa, CHs, Cl, Ph, Η), (M-12524, CHa, CH3, Cl, Ph, Cl), (M-12525, CH3, CHa, Cl, Ph, F), (M-12526, CHs, CHa, Cl, Ph, CFa), (M-12527, Clin, Clla, 01, Ph, Hr), (M^2528l CHs, CH3, Cl, Ph, CHa), (M-12529, CHs, CHs, Cl, 4-F-Ph, Η), (M-12530, CHa, CHa, Cl, 4-F-Ph, Cl), (M-12531, CHs, CH3, Cl, 4-F-Ph, F), (M-12532, CHa, CHa, Cl, 4-F-Ph, CF3), (M-12533, CH3, CH3, Cl, 4-F-Ph, Br), (M-12534, CH3, CH3, Cl， 4-F-Ph, CH3), (M-12535, CH3, CH3, Cl, 4-CF3-Ph, Η), (M-12536, CH3, CH3, Cl， 4-CF3-Ph, Cl), (M-12537, CH3, CH3, Cl, 4-CF3-Ph, F), (M-12538, CH3, CH3, Cl， 4-CF3-PI1, CF3), (M-12539, CH3, CH3, Cl, 4-CF3-Ph, Br), (M-12540, CHs，CH3, Cl， 4-CF3-Ph, CH3), (M-12541, CH3, CHa, Cl, 4-(Me)2N-Ph, Η), (M-12542, CH3, CH3, Cl, 4-(Me)2N-Ph, Cl), (M-12543, CH3, CH3, Cl, 4-(Me)2N-Ph，F)，（M-12544, CH3, CHa, Ci, 4-(Me)2N.Ph, CFa), (M-12545, CHa, CHa, Cl, 4-(Me)2N.Ph, Br), (M-12546, CHs, CHa, Cl, 4-(Me)2N-Ph, CHa), (M-12547, CHs, CHa, Cl, 4-OH-Ph, H), (M-12548, CH3, CH3, Cl, 4-OH-Ph, Cl), (M-12549, CH3, CH3, Cl, 4-OH-Ph, F>, (M-12550, CH3, CH3, Cl, 4-OH-Ph, CF3), (M-12551, CH3, CH3, Cl, 4-OH-Ph, Br)， (M-12552, CH3, CH3, Cl, 4-OH-Ph, CH3), (M-12553, CH3, CH3, Cl, 3,4-di-F-Ph, Η), (M-12554, CHa, CHs, Cl, 3,4-di-F.Ph, Cl), (M-12655, CHa, CH3, Cl, 3,4-di. F-Ph, F), (M-12556, CHs, CHa, Cl, 3,4-di-F-Ph, CFa), (M-12557, CH3, CHa, Cl, 3,4-di-F-Ph, Br), (M.12558, CH3, CH3, Cl, 3,4-di-F-Ph, CH3), (M-12559, CHs, CH3, Cl, 4-COOH-Ph, Η), (M-12560, CH3, CH3, Cl, 4-COOH-Ph，Cl), (M-12561， CH3, CHs, Cl, 4-COOH.Ph, F), (M-12562, CHa, CHa, Cl, 4-COOH-Ph, CFs), (M-12563, CH3, CH3, Cl, 4-COOH-Ph, Br), (M-12564, CH3, CH3, Cl, 4-COOH· Ph, CHa), (M-12565, CHs, CHa, Cl, Bn, Η), (M-12566, CHa, CH3, Cl, Bn, Cl), (M-12567, CH3, CHs, Cl, Bn, F), (M-12568, CH3, CHa, Cl, Bn, CFs), (M-12569, 310 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請·先閱讀I面之注意事項 本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7
Br)?(M-12570, CHa, CH3, Cl, Bn, CHa), (M-12571, CHa, CHa, Cl, 4-F.Bn, Η), (M-12572, CHa, CHa, Cl, 4-F-Bn, Cl), (M-12573, CHa, CH3, Cl, 4-F-Bn, F), (M-12574, CHa, CHa, Cl, 4-F.Bn, CFa), (M-12576, CHa, CHa, Cl, 4-F-Bn,Br),(M-12576,CH3,CH3,Cl,4-F-Bn,CH3),(M-12577,CH3,CH3,Cl,2· Py, Η), (M-12578, CHa, Clh, Cl, 2-Py, Cl), (M.12R79, Gila, Clla, Cl, 2-Py. F), (M-12580, CHs, CH3, Cl, 2-Py, CFs), (M-12581, CHa, CHs, Cl, 2-Py, Br), (M- 12582, CH3, CH3, Cl, 2-Py, CHa), (M-12583, CH3, CH3, Cl, 3-Py, Η), (M-12584, CH3, CH3, Cl, 3-Py, Cl), (M-12585, CH3, CH3, Cl, 3-Py, F), (M-12586, CH3, CH3, Cl, 3-Py, CFs), (M-12587, CHs, CHs, Cl, 3-Py, Br), (M-12588, CHa, CH3, Cl, 3-Py, CH3), (M-12589, CH3, CH3, Cl，4-Py, Η), (M-12590, CH3, CH3, Cl, 4-Py, Cl), (M-12591, CH3, CH3, Cl, 4-Py, F), (M-12592, CH3, CH3, Cl, 4-Py, CF3), (M· 12593, CH3, CH3, Cl, 4-Py，Br), (M-12594, CH3, CH3, Cl, 4-Py, CH3>, (M-12595, CH3, CHs, Cl, 2-Th, Η), (M-12596, CHa, CHa, Cl, 2-Th, Cl), (M-12597, CHa, CHa, Cl, 2-Th, F), (M-12598, CHa, CH3, Cl, 2-Th, CF3), (M-12599, CHa, CHa, Cl, 2-Th, Br), (M-12600, CH3, CHa, Cl, 2-Th, CHa), (M-12601, CHa, CHa, Cl, 3-Th, H), (M-12602, CHa, CH3, Cl, 3-Th, Cl), (M-12603, CH3, CH3, Cl, 3-Th, F)，（M-12604, CH3, CH3, Cl, 3-Th, CF3), (M-12605, CH3, CH3, Cl, 3-Th, Br), (M-12606, CH3, CH3, Cl, 3-Th, CH3), (M-12607, CH3, CH3, Cl,吡嗤-2-基，Η), (M-12608, CH3, CH3, Cl,吡唑-2-基，Cl), (M-12609, CH3, CH3, Cl,吡唑-2-基，F)，（M-12G10, CH3, CH3, Cl,吡唑-2-基，CF3), (M-12611, CH3, CH3, Cl，吡唑-2-基，Br)， (M-12612, CH3, CH3, Cl,社唑-2-基，CH3)，（M-12613, CH3, CH3, Cl, 吡唑·3-基，Η), (M-12614, CH3, CH3, Cl,吡唑-3-基，Cl), (M-12615, CH3, CH3, Cl,吡唑-3-基，F), (M-12616, CH3, CH3, Cl，吡唑-3-基，CF3), (M· 12617, CH3, CH3, Cl,吡唑-3-基，Br), (Μ·12618, CH3, CH3, Cl,吡唑-3-基， CH3), (M-12619, CH3, CH3, Cl,嘧啶-2·基，Η), (M-12620, CH3, CH3, Cl, 嘧啶-2·基，C1), (M-12621，CH3, CH3, Cl,嘧啶-2-基，F), (M-12622, CH3, 311 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） (請•先閱讀脊面之注意事項 本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 __B7_.__ ,(Μ-12623, CH3, CH3, Cl,喃 _ -2-基，Br), (M-12624, CH3, CH3, Cl,嘧啶-2-基，CH3), (M-12625, CH3, CH3, Cl， 嘧啶-4-基，H>, (M-12626, CH3, CH3, Cl,嘧啶-4-基，C1)，（M-12627, CH3, CH3, Cl,嘧啶-4-基，F), (M-12628, CH3, CH3, Cl,嘧啶-4-基，CF3), (M-12629, CH3, CH3, Cl,嘧啶-4-基，I3r), (M.12630, Cl卜，Clh· Cl, 1喃啶-4-基，CH3), (M-12631, CH3, CH3, Cl,嘧啶-5-基，Η), (M-12632, CH3, CH3, Cl,嘧啶-5-基，Cl>, (M-12633, CH3, CH3, Cl,嘧啶-5·基，F), (M-12634, CH3, CH3, Cl,嘧啶-5-基，CF3), (M-12635, CH3, CH3, Cl, 嘧啶-5-基 ” Br), (M-12636, CH3, CH3, Cl,嘧啶-5-基，CH3)，（Μ·12637, CHa, CHa, Cl, HOOCCH2CH2CH2, Η), (M-12638, CHa, CH3, Cl, HOOCCH2CH2CH2, Cl), (M-12639, CH3, CH3, Cl, HOOCCH2CH2CH2, F)，（M· 12640, CHa, CHs, Cl, HOOCCH2CH2CH2, CFa), (M-12641, CHa, CHa, Cl, HOOCCH2CH2CH2, Br), (M-12642, CHa, CHa, Cl, HOOCCH2CH2CH2, CHa), (M-12643, CHs, CH3, Cl, HOOCCH2CH2CH2CH2, Η), (M-12644, CHa, CHa, Cl, HOOCCH2CH2CH2CH2, Cl), (M-12645, CHa, CHa, Cl, HOOCCH2CH2CH2CH2, F), (M-12646, CHa, CH3, Cl, HOOCCH2CH2CH2CH2, CFa), (M-12647, CH3, CHs, Cl, HOOCCH2CH2CH2CH2, Br), (M-12648, CHa, CHa, Cl, HOOCCH2CH2CH2CH2, CHs), (M-12649, CHs, CHs, Cl, (Me)2NCOCH2CH2CH2CH2, Η), (M-12650, CH3, CH3, Cl, (Me)2NCOCH2CH2CH2CH2, Cl), (M-12651, CH3, CH3, Cl, (Me)2NCOCH2CH2CH2CH2, F), (M-12652, CH3, CH3, Cl, (Me)2NCOCH2CH2CH2CH2, CF3), (M-12653, CH3, CH3, Cl, (Me)2NCOCH2CH2CH2CH2, Br), (M-12654, CH3, CH3, Cl, (Me>2NCOCH2CH2CH2CH2, CH3), (M-12655, CH3, CH3, Cl， (Me)2NCOCH2CH2CH2CH2CH2, Η), (M-12656, CH3, CH3, Cl， (Me)2NCOCH2CH2CH2CH2CH2, Cl), (M-12657, CH3, CH3, Cl, 312 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項\一 『本頁) 經濟部智慧財產局員工消費合作社印製 1284639 Δ7 A7 B7 (M-12658, CHa, CHa, Cl, (Me)2NCOCH2CH2CH2CH2CH2, CFs), (M-12659, CHa, CHa, Cl, (Me)2NCOCH2CH2CH2CH2CH2, Br), (M-12660, CH3, CH3, Cl, (Me>2NCOCH2CH2CH2CH2CH2, CH3), (M-12661, CH3, CH3, Cl, MeOCH2, H), (M-12662, CH3, CHa, Cl, MeOCIh, Cl), (M-12663, CHn, Clin, Cl, MoOCUa, F), (M-12664, CHa, CHa, Cl, MeOCH2, CFa), (M-12665, CHa, CHa, Cl, MeOCH2, Br), (M-12666, CH3, CH3, Cl, MeOCH2, CH3), (M-12667, CH3, CH3, Cl, EtOCH2, H)， (M-12668, CH3, CH3, Cl, EtOCH2, Cl), (M-12669, CH3, CH3, Cl, EtOCH2, F)， (M-12670, CH3, CH3, Cl, EtOCH2, CF3), (M-12671, CH3, CH3, Cl, EtOCH2, Br>， (M-12672, CH3, CH3, Cl, EtOCH2, CH3), (M-12673, CH3, CH3, Cl, EtOCH2CH2, Η), (M-12674, CH3, CH3, Cl, EtOCH2CH2, Cl), (M-12675, CH3, CH3, Cl， EtOCH2CH2, F>, (M-12676, CH3, CH3, Cl, EtOCH2CH2, CF3), (M· 12677, CH3， CH3, Cl, EtOCH2CH2, Br), (M-12678, CH3, CH3, Cl, EtOCH2CH2, CH3)，（M· 12G79, CHa, CH3, Cl, MeOCH2CH2〇CH2CH2, Η), (M-12680, CH3, CH3, Cl， MeOCH2CH2〇CH2CH2, Cl), (M-12681, CH3, CH3, Cl, MeOCH2CH2〇CH2CH2, F)， (M-12682, CH3, CH3, Cl, MeOCH2CH2〇CH2CH2, CF3), (M-12683, CH3, CH3, Cl， MeOCH2CH2〇CH2CH2, Br), (M-12684, CH3, CH3, Cl, MeOCH2CH2〇CH2CH2, CHa), (M-12685, CHs, CH3, Cl, MeOCH2CH2, Η), (M-12686, CHa, CHa, Cl, MeOCH2CH2, Cl), (M-12687, CHs, CHa, Cl, MeOCH2CH2, F), (M-12688, CHs, CH3, Cl, MeOCH2CH2, CF3), (M-12689, CH3, CH3, Cl, MeOCH2CH2, Br), (M-12690, CH3, CH3, Cl, MeOCH2CH2, CH3), (M-12691, CH3, CH3, Cl, HOCH2, H)， (M-12692, CHs, CHs, Cl, HOCH2, Cl), (M-12693, CHs, CHa, Cl, HOCH2, F), (M-12694, CHs, CHs, Cl, HOCH2, CFa), (M-12695, CHs, CHs, Cl, HOCH2, Br), (M-12696, CH3, CH3, Cl, HOCH2, CHs), (M-12697, CHa, CH3, Cl, HOCH2CH2, Η), (M-12698, CHa, CH3, Cl, HOCH2CH2, Cl), (M-12699, CHa, CHa, Cl, HOCH2CH2, F), (M-12700, CH3, CHa, Cl, HOCH2CH2, CF3), (M-12701, CH3, 313 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項 本頁) 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 ^Hs, ,(M-12702, CHs, CHa, Cl, HOCH2CH2, CH3), (M-12703, (請•先閱讀铲面之注意事項本頁) 經濟部智慧財產局員工消費合作社印製 CHa, CHs, Cl, HOCH2CH2CH2, Η), (M-12704, CHa, CHa, Cl, HOCH2CH2CH2> Cl), (M-12705, CHa, CHs, Cl, HOCH2CH2CH2, F), (M-12706, CHa, CHa, Cl, HOCH2CH2CH2, CFs), (M-12707, CHa, CHs, Cl, HOCH2CH2CH2, Br), (M-12708, CHa, CHa, Cl, HOCH2CH2CII2, CIIs), (M-12709, CAht Clla, 01. HOCH2CH2CH2CH2, Η), (M-12710, CHa, CHs, Cl, HOCH2CH2CH2CH2, Cl), (M-12711, CHa, CHa, Cl, HOCH2CH2CH2CH2, F), (M-12712, CHa, CHa, Cl, HOCH2CH2CH2CH2, CFs), (M-12713, CHa, CHa, Cl, HOCH2CH2CH2CH2, Br), (M-12714, CH3, CHa, Cl, HOCH2CH2CH2CH2, CHa), (M-12715, CHa, CH3, Cl, HOCH2CH2CH2CH2CH2, Η), (M-12716, CHa, CHa, Cl, HOCH2CH2CH2CH2CH2, Cl), (M-12717, CH3, CHs, Cl, HOCH2CH2CH2CH2CH2, F), (M-12718, CHa, CH3, Cl, HOCH2CH2CH2CH2CH2, CFa), (M-12719, CHa, CHa, Cl, HOCH2CH2CH2CH2CH2, Br), (M-12720, CH3, CHa, Cl, HOCH2CH2CH2CH2CH2, CHs), (M-12721, CHs, CHa, Cl, HOCH2CH2OCH2CH2, Η), (M-12722, CH3, CHs, Cl, HOCH2CH2OCH2CH2, Cl), (M-12723, CHs, CHs^ Cl, HOCHaCHaOCHaCHa, F), (M-12724, CHs, CHa, Cl, HOCH2CH2OCH2CH2, CFa), (M-12725, CH3, CH3, Cl, HOCH2CH2OCH2CH2, Br), (M-12726, CHa, CH3, Cl, HOCH2CH2OCH2CH2, CH3), (M-12727, CH3, CH3, Cl, (Me)2N, Η), (M-12728, CH3, CH3, Cl, (Me)2N, Cl), (M-12729, CHa, CHa, Cl, (Me)2N, F), (M-12730, CHa, CHa, Cl, (Me)2N, CFs), (M-12731, CH3, CH3, Cl, (Me)2N, Br), (M-12732, CH3, CH3, Cl, (Me)2N, CH3)， (M-12733, CH3, CHa Cl,哌啶-4 -基甲基,Η), (M-12734, CH3, CH3, Cl， 哌啶 4 -基甲基，Cl), (M-l2735, CH3, CH3, Cl,哌啶-4 -基甲基，F)， (M-12736, CH3, CH3, Cl,哌啶-4-基甲基，CF3), (M-12737, CH3, CH3, Cl， 哌啶-4 -基甲基 _ B'r), (Μ·12738, CH3, CH3, Cl,哌啶-4 -基甲基， CH3), (M-12739, CH3, CH3, Cl,環己基甲基，Η), (M-12740, CH3, CH3, Cl， 環己基甲基，Cl), (M-l2741, CH3, CH3, Cl,環己基甲基，F)，（M- 314 未紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） ： 1284639 A7 B7 五、發明說明（#) (請·先閱讀f-面之注音？事項本頁) 12742, CH3, CH3, C1,環己基甲基，CFs), (M-12743, CHs，CH3, C1， 環己基甲基丨,Br), (M-12744, CH3, CH3, Cl,環己基甲基/出乂⑽-12745, Η, Η, H, CF3, Η), (Μ·12746, Η, Η, H, CF3, Cl), (M.12747, Η, Η, H, CF3, F), (Μ-12748, Η, Η, Η, CF3, CF3), (Μ-12749, Η, Η, Η, CF3, Br), (Μ-12750, Η, Η， Η, CFa, CHa), (Μ-12761, II, II, F, CFa, Η), (Μ-127Γ,2, Π, II, Κ, C\^t (Ί), (Μ027ΠΪ1, Η, Η, F, CFs, F), (Μ-12754, Η, Η, F, CFa, CFa), (Μ-12755, Η, Η, F, CFa, Br), (Μ-12756, Η, Η, F, CF3, CH3), (Μ·127δ7, Η, Η, Cl, CF3, Η), (Μ-12758, Η, Η, Cl, CFa, Cl), (Μ-12759, Η, Η, Cl, CFa, F), (Μ-12760, Η, Η, Cl, CFa, CFa), (Μ-12761, 經濟部智慧財產局員工消費合作社印製 Η, Η, Cl, CF3, Br), (Μ-12762, Η, Η, Cl, CF3, CH3), (Μ·12763, Η，F, Η, CF3, Η)， (Μ-12764, Η, F, Η, CF3, Cl), (Μ-12765, Η, F, Η, CF3, F), (Μ-12766, Η, F，Η, CF3, CF3), (Μ-12767, Η, F, Η, CF3, Br), (Μ-12768, Η, F, Η, CF3, CH3), (Μ-12769, Η， F, F, CFa, Η), (Μ-12770, Η, F, F, CF3, Cl), (Μ-12771, Η, F, F, CF3, F), (Μ-12772, Η, F, F, CFs, CFa), (Μ-12773, Η, F, F, CFa, Br), (Μ-12774, Η, F, F, CFa, CHa), (Μ-12775, Η, F, Cl, CF3, Η), (Μ-12776, Η, F, Cl, CF3, Cl), (Μ-12777, Η, F, Cl, CF3, F), (Μ-12778, Η, F, Cl, CF3, CF3), (Μ-12779, Η, F, Cl, CF3, Br), (Μ-12780, H, F, Cl, CF3, CH3), (M-12781, H, CH3, H, CF3, Η), (M-12782, H, CH3, H, CF3, Cl), (M-12783, H, CHs, H, CFa, F), (M-12784, H, CH3, H, CF3, CFa), (M-12785, H, CHs, H, CFa, Br), (M-12786, H, CHa, H, CFa, CHa), (M-12787, H, CHa, F, CFa, H), (M-12788, H, CHa, F, CFs, Cl), (M-12789, H, CHs, F, CFa, F), (M-12790, H, CHs, F, CFa, CFa), (M-12791, H, CHs, F, CFa, Br), (M-12792, H, CHa, F, CFa, CHa), (M-12793, H, CHa, Cl; CFa, Η), (M-12794, H, CHa, Cl, CFa, Cl), (M-12795, H, CH3, Cl, CFs, F), (M-12796, H, CH3, Cl, CFa, CFs), (M-12797, H, CHa, Cl, CF3, Br), (Μ·12798, H, CH3, Cl, CF3, CH3), (M-12799, F, Η, H, CF3, i-Pr), (M-12800, F, Η, H，CF3, Cl>, (M-12801, F, Η, H, CF3, F), (M-12802, F, H，H, CF3, CF3)， (M-12803, F, Η, H, CF3, Br), (M-12804, F, Η, H, CF3, CH3)，（M-12805, F, H, F, CF3, Η), (M-12806, F, H, F, CF3, Cl), (M-12807, F, H, F, CF3, F)，（M-12808, F，H， 315 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 五 經濟部智慧此產局員工消費合作社印製 (請先閱讀背面之注意事項再填寫本頁) 、麗 aw H, F, CF.i, Br), (M-12810, F, H, F, CF^ Cli：〇. (M-12811, F, H, Cl, CF,3, H), (M-12812, F, H, Cl, Cl), (M-1281；}. F, 11, Cl. CFr. F), (M-12814, F, H, Cl, CFn, CPa), (M-12815, F, II, Cl, CF.^ Br), (M-12816. F. H. Cl. CFa, CHs), (M-12817, F, F, H, CFa, Η), (M-12818, F, F, H, CF3, Cl), (M-12819. F, F, H, CF：i, F), (M-12820, K, F, II, 0\^λ, (ΊΛι), (M-I2K2I, l\ K, II, (ΊΛμ, HrV (M-12822, F, F, H, CFa, CH3), (M-12823, F, F, F, CF；i, IJ), (M-12824, F, F, F, CF3, Cl), (M-12825, F, F, F, CF,m, F), (M-1282(5, ΙΛ K, K, (ΜΛ·ι, CF；〇. (M-12827, K. F. F, CFa, Br), (M-12828, F, F, F, CFa, CHn), (M-12829, F, F, Cl, CF3, Η). (M-12830. F. F; Cl, CFs, Cl), (M-12831, F, F, Cl, CFs, F), (M-12832, F, F, Cl, CF3? CFs), (M-12833, F, F, Cl, CF3, Br), (M-12834, F, F, Cl, CFa, CII3), (M-12835, F, CH3, II. CF.3, Η), (M-12836, F, CII3, II, CF^f Cl), (M-12837. P, CIIm, II, CFm, F). (M-12838. F. CII3, H, CF.3, CFrj), (Μ-128：}ί), Γ, Clin, H, CFm, Hr), (M-12840, ΙΛ CHa. H, CFa, CII.O, (M-12841, F, CHn, P, H), (M-12842, P, CUn, ΙΛ CFm. (Ί). (M-1281；t. F. CH3, F, CFa, F), (M-12844, F, CII3, F, CF3, CFa), (M-12845, F, CII3, F, CFs, Br). (M-12846, F, CHs, F, CF3, CH3), (M-12847, F, CHa, Cl, CFa, Η), (M-12848, F. CH.3, Cl, CFa, Cl), (M-12849, F, CII3, Cl, CFn, F), (M-12850, F, CII3, Cl, CF3. CF3), (M-12851, F, CHs, Cl, CF3, Br), (M-12852, F, CH.% Cl. CF3, CHn), (M-12853, Cl, Η, H, CF3, i-Pr), (M-12854, Cl, Π, II, CF3, Cl), (M-12855, Cl. II, H, CF.3, F), (M-12856, Cl, II, Η, ΟΙΛμ, CFa), (M-12857, Cl, II, II, CKn, Br), (M-12858. Cl, Η, H, CFs, CH3), (M-12859, Cl, H, F, OF.% i-Pr), (M-12860, Cl, II, F, CF3. Cl). (M-12861, Cl, H, F, CF.% F), (M-12862, Cl, II, F, CF；j, CF.i), (M-128G3, Cl, II, F, CFe, Br), (M-12864, Cl, H, F, CFs, CII3), (M-12865, Cl, H, Cl, CF3, Η), (M-12866, Cl, H, Cl, CFs, Cl), (M-12867, Cl, H, Cl, CFa, F), (M-12868, Cl, H, Cl, CFa, CFs), (M-12869, Cl, H, Cl, CF3, Br)，（M-12870, Cl, II，Cl, CF3, Clh)，（M-12871, Cl, F\ H’ CF3, i-Pr), (M-12872, Cl, F，II, CF3, Cl)，（M-12873, Cl，F，H· CF& F), (M· 12874, Cl, F, H, CF3, CF3), (M-12875, Cl, F, H, CF3, Br), (M-12876, Cl. F, II. CF：3. 316 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） 1284639 A7
經濟部智慧財產局員工消費合作社印製 五、發明說明 CH3), (Μ·12877, Cl, F, F, CF3, H)，（M-12878, Cl, F, F, CF3, C1)，（Μ·12879, Cl, F， F, CF3, F), (M-12880, Cl, F, F, CFa, CF3), (M-12881, Cl, F, F, CF3, Br), (M-12882, Cl, F, F, CF3, CH3), (M-12883, Cl, F, Cl, CPa, Η), (M-12884, Cl, F, CK CF3. Cl). (M-12885, Cl，F，Cl, CF3, F), (M-12886, Cl, F, Cl, CF3, CF3)，（M-12887, Cl，F· Cl, Hr), (M-12888, Cl, Cl, CK；,, CII：,), (M-I2HH!), (Ί, (ΊΙ；,, II, (ΊΛ», (M-12890, Cl, CHs, H, CF3, Cl), (M-12891, Cl, CII3, II, CFe, F), (M-12892, Cl· CH3, H, CF3, CF3), (Μ-1289：5, Cl, CHa, II, Br), (M-12894, Cl, Clla, II. CH3), (M-12895, Cl, CH.3, F, CF3, i-Pr), (M-12896, Cl, CH3, F, CF3, Cl), (M-12897, Cl, CH3, F, CFs, F), (M-12898, Cl, CII3, F, CFa, CFa), (M-12899. Cl. CHs. F? CF3, Br), (M-12900, Cl, CHn, F, CF.3, CH3), (M-12901, Cl, CIb, Cl, CF3. II). (M-12902, Cl, CH3, Cl, CFa, Cl), (M-12903, Cl, CII3, Cl, CF3, F). (M-12904, Cl. CHa, Cl, CF,3, CF3), (M-12905, Cl, CII3, Cl, CF3, Br), (M-12006, Cl, CII3, Cl, CF3, CH3), (M-12907, CII3, II, II, CF3, i-Pr), (M-12908, CHa, II. H. CF3. Cl). (M-l 2909. CH3, Η, H, CFs, F), (M-12910, CII3, Η, H, CF3, CF3), (M-12911, CHa, Η, H. CF3, Br), (M-12912, CHs, Η, H, CF3, CII3), (M-12913, CII3, H, F, CF3, H), (M<12914, CH3, H, F, CF3, Cl), (M-12915, CH3, H, F, CF3, F), (M-12916, CII3. H. F. CFs. CFa), (M-12917, CH3, II, F, CF3, Br), (M-12918, CHa, II, F, CF3, CH：〇, (M-12919, CH.3, H, Cl, CF,3, H), (M-12920, CHs, H, Cl, CF3, Cl), (M-12921, CII3, H. CL CFs, F), (M-12922, CH3, H，Cl，CIW, (M-12i)2:U〕H:Ul，Cl, Ch, Br), CHs, H, Cl, CFs, CH3), (M-12925, CHa, F, H, CF3, Η), (M-12926, CHs, F, H, CFs. Cl), (M-12927, CH.3, F, H, CPa, F), (M-12928, Clht F, H, CFa, CFa), (M-12929. CH.3, F, H, CF,3, Br), (M-12930, CII3, F, H, ("Ηπ), (Μ-12ϊ)：Π, Cll^ F. F. C^. Η), (M-12932, CH3, F, F, CP3, Cl), (M-12933, Clin, F, F, CF.^ F), (M-12934. CH3, F, F, CF3, CF3), (M-12935, CII：i, F, CF3, Hr), (Μ-12ί)；^(；, C\\^ F, F, CFa, (M-12937, CH.3, F, Cl, CF.% Π), (M-12938, CH,, F, Cl, CF., Cl), (M-12939. CH3. F. Cl, CF3, F), (M-12940, CII3, F, Cl, CFn, CFn), (M-12941. CMa, F. Cl. CF3, Br). 317 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --------^--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（Vi) (M-12942, CHa, F, Cl, CFa, CHa), (M-12943, CHa, CHa, H, CFa, Η), (M-12944, CHa, CHa, H, CFa, Cl), (M-12945, CHs, CHa, H, CFs, F), (M-12946, CHa, CHa, H, CF3, CF3), (M-12947, CH3, CHa, H, CF3, Br), (M-12948, CH3, CH3, H, CF3, CH3), (M-12949, CHa, CHa, F, CFa, Η), (M-12950, CHa, CHa, F, CFa, Cl), (M-12951, CHst CHa, F, CFs, F), (M-12952, Clla, CM.% K, 〇Fa, CKm), (M.12J)5a, CAh, C\hu h\ CFa, Br), (M-12954, CHa, CHa, F, CFs, CHa), (M-12955, CHa, CHs, Cl, CFa, H), (M-12956, CHs, CHa, Cl, CFs, Cl), (M-12957, CH3, CHa, Cl, CFa, F), (M-12958, CHa, CHa, Cl, CFa, CF3), (M-12959, CHa, CHa, Cl, CFa, Br), (M-12960, CHa, CUs. Cl, CF3, CH3>· 試驗例1 血栓形成TPO)之單離及精製 人及小白鼠TPO購自R&D Systems公司。 試驗例2 由於化合物（B-1 )之試管內巨核血球集落增加作 用 本化合物對巨核血球系細胞增殖、分化、成熟之作用用人 骨髓細胞，在甲基纖維素之半固形培養依巨核血球集落形成 法調查。人骨髓細胞2.2 xlO5播種在3 cm之皿，添加溶在10% 乙醇之化合物1%，在37°C，5%二氧化碳之存在下培養7曰來 測定巨核血球集落數，結果如圖1。 試驗例3 化合物（B-1 )之TPO受體反應性 本化合物之TPO受體反應性仿Collins等J. Cell，Physiol·， 1 37:293-298 ( 1 988 )之方法，用將人TPO受體基因導入 BaF-B03細胞來作成之TPO依存性細胞株BaF/hTPOR測定。 編碼TPO受體之基因之鹼基序列記載於Bigon等Proc. Natl· Acad· Sci. 89:5640-5644 ( 1992 )。母株 BaF-B03 細胞則無反 -318· 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ---------I --------訂--------- (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 _B7__ 五、發明說明 應性。在添加l〇%WEHI-3培養液之RPMI培養基增殖之 BaF/hTPOR細胞以PBS洗1次後，懸浮在無添加10%WEHI-3 培養液之RPMI培養基，在96穴微板播種細胞爲5x1 04/穴而 添加本化合物或TPO。在371，5%二氧化碳之存在下培養20 小時後，添加細胞增殖判定試劑，即WST-1試劑（寶酒造公 司），4小時後，測定450nm之吸收，結果如圖2。又測定將同 樣作成之表現小白鼠TPO受體之BaF/hTPOR之反應性，結果 如圖3。以ED5G爲呈現人TPO之半最大反應性之化合物之濃 度，各化合物之ED5Q如表33。 -I ^------------- (請先閱讀背面之注意事項再填寫本頁) tr---------着- 經濟部智慧財產局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 B7 化合物 No. EDbo (μΜ) 化合物 No. EDbo (μΜ) 化合物 No. EDbo (μΜ) 化合物 No. ED50 (μΜ) Α·1 0.117 Α-54 0.065 Β-6 0.084 G-5 0.260 Α·2 0.066 Α-55 0.037 Β·7 0.059 G-6 0.370 Α·3 0.218 Α-56 0.066 Β-8 0.378 G-7 0.400 Λ·4 0.124 Λ-Γ,7 0.019 Π-9 0.082 (Ί·8 ο,ηοο Α·5 0.984 Λ-58 0.497 Β-11 0.23G II-7 ϋ.ϋ；38 Α·6 0.248 Α·59 0.164 Β·12 0.207 Η·8 0.250 Α-8 0.529 Α-60 0.023 Β-13 0.213 J-ll 0.311 Α-9 0.504 Α-61 0.207 Β-14 0.305 J-12 0.107 Α-10 0.365 Α-62 0.101 Β-15 0.197 J-13 0.116 Α-11 0.0335 Α·63 0.025 Β-16 0.182 J-14 0.036 Α-14 0.017 Α-64 0.204 Β-17 0.244 J-15 0.011 Α-17 0.864 Α-65 0.028 Β-18 0.15 Κ·1 0.189 Α-18 0.132 Α-66 0.211 Β-19 0.15 Κ·2 0.975 Α-19 0.170 Α-68 0.222 Β·20 0.425 Κ·3 0.693 Α-20 0.610 Α-69 0.071 Β·25 0.367 Κ·5 0.403 Α-23 0.337 Α-70 0.089 Β-26 0.346 Κ-6 0.077 Α-24 0.288 Α-72 0.119 Β-27 0.707 Κ·10 0.475 Α·25 0.150 Α-73 0.075 Β-28 0.565 Κ-11 0.373 Α-26 0.098 Α-74 0.472 Β-29 0.181 Κ-12 0.208 Α·27 0.193 Α-75 0.073 Β-30 0.177 Κ-13 0.260 Α-28 0.099 Α-76 0.205 Β·31 0.178 Κ-15 0.465 Α-29 0.289 Α-77 0.110 Β-32 0.123 L-1 0.208 Α-30 0.274 Α·78 0.408 Β·33 0.372 L-2 0.143 Α-31 0.056 Α·79 0.410 Β·34 0.398 L-3 0.321 Α·32 0.040 Α·80 0.066 Β-35 0.186 L-4 0.256 Α-35 0.096 Α-81 0.071 Β·36 0.163 Α·36 0.095 Α-82 0.199 Β-37 0.139 Α-37 0.096 Α-83 0.077 Β-38 0.239 Α-38 0.245 Α-84 0.023 Β-39 0.729 Α·39 0.044 Α-85 0.026 Β-40 0.201 Α·40 0.047 Α-86 0.243 Β-41 0.19 Α-41 0.039 Α-87 0.710 Β-42 0.236 Α-42 0.050 Λ-88 0.028 Β-43 0.303 Α-43 0.071 Α·89 0.072 Β-46 0.213 Α-44 0.227 Α-90 0.805 C-4 0.922 Α-45 0.203 Α·91 0.076 D-1 0.276 Α-46 0.263 Α-92 0.178 F-1 0.174 Α-47 0.512 Α·93 0.008 F-2 0.144 Α-48 0.473 Β·1 0.081 F-3 0.198 Α·49 0.116 Β-2 0.257 G-1 0.261 Α-50 0.113 Β·3 0.156 G-2 0.299 Α-51 0.568 Β-4 0.089 G-3 0.430 Α·52 0.425 Β-5 0.123 G-4 0.240 320 --------------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 1284639 A7 B7 五、發明說明（V?) 如第1圖所示，添加本化合物單獨形成巨核血球集落，集落 數隨濃度增加。以上結果顯示本化合物單獨促進巨核血球前 驅細胞之增殖、分化而產生具有血小板產生能力之巨核血球。 如第2圖所示，本化合物隨濃度增殖TPO依存性細胞株 BaF/hTPOR細胞。如圖3所示，本化合物對表現小白鼠TPO 受體之BaF/hTPOR無反應。以上結果顯示本化合物對人TPO 受體專一地作用，而呈TPO激動作用。 製劑例1 製造含下列成分之顆粒劑： II——〆------ (請先閱讀背面之注意事項再填寫本頁) 式（I )化合物 1 Omg 乳糖 700 玉米澱粉 274 HPC-L_16 共 lOOOmg 將式（I)化合物及乳糖篩經60號篩，玉米篩經12〇號篩， 這些在V型混合機混合，力HPC-L (低粘度羥丙基纖維素） 水溶液，予以捏合、造粒（擠壓造粒，孔徑〇·5〜1mm)。乾燥 後，所得顆粒篩經振動篩（12/60號篩），得顆粒劑。 製劑例2 訂---------^0 經濟部智慧財產局員工消費合作社印製 製造含下列成分之膠囊充塡用散劑： 式（I)化合物 1 Omg 乳糖 79 玉米澱粉 10 硬脂酴餻 1 -321- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 經濟部智慧財產局員工消費合作社印製 1284639 A7 ________ 五、發明說明 如第1圖所示，添加本化合物單獨形成巨核血球集落，集落 數隨濃度增加。以上結果顯示本化合物單獨促進巨核血球前 驅細胞之增殖、分化而產生具有血小板產生能力之巨核血球。 如第2圖所示，本化合物隨濃度增殖TPO依存性細胞株 BaF/hTPOR細胞。如圖3所示，本化合物對表現小白鼠TPO 受體之BaF/hTPOR無反應。以上結果顯示本化合物對人TPO 受體專一地作用，而呈TPO激動作用。 製劑例1 製造含下列成分之顆粒劑： 式（I )化合物 10mg 乳糖 700 玉米澱粉 274 HPC-L_16 共 lOOOmg 將式（I )化合物及乳糖篩經60號篩，玉米篩經1 20號篩， 這些在V型混合機混合，加HPC-L (低粘度羥丙基纖維素） 水溶液，予以捏合、造粒（擠壓造粒，孔徑0.5〜1mm)。乾燥 後，所得顆粒篩經振動篩（12/60號篩），得顆粒劑。 製劑例2 製造含下列成分之膠囊充塡用散劑： 式（I)化合物 10mg 乳糖 79 玉米澱粉 10 硬脂酸銻 1 共 100mg
-321-A 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --------訂---------. (請先閱讀背面之注意事項再填寫本頁) 1284639 A7 B7 五、發明說明（—w) 將式（I )化合物及乳糖篩經60號篩，玉米篩經1 20號篩， 這些與硬脂酸鎂在V型混合機混合。將10倍散lOOmg充塡 在5號硬膠囊。 製劑例3 製造含下列成分之膠囊充塡用顆粒劑： 式（I)化合物 15mg 乳糖 90 玉米澱粉 42 HPC-L _3 共 150mg 將式（I)化合物及乳糖篩經60號篩，玉米篩經120號篩，這 些混合而加HPC-L水溶液，予以捏合、造粒、乾燥後，所得顆 粒予以造粒，分150mg充塡在4號硬膠囊。 製劑例4 丨：---μ------ r清先閱璜背面之庄音？事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 製造含下列成分之錠劑： 式（I)化合物 1 Omg 乳糖 90 微結晶纖維素 30 CMC-Na 15 硬脂酸鏵 _ 5 共 1 5 Omg 將式（I)化合物、乳糖、微結晶纖維素、CMC-Na (羧甲 基纖維素鈉）篩經60號篩而混合硬脂酸鎂，。混合後，用打錠 機壓縮，得各重150mg之錠劑。 -322- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 訂---------着· 1284639 A7 B7 五、發明說明 製劑例5 製造含下列成分之靜脈注射劑： 式（I)化合物 lOOmg 飽和脂肪酸甘油酯 1000 所得溶液通常以每分1 m之速度靜脈注射。 產業上利用可能性 本發明化合物具有血栓形成素受體激動作用，有效當作血 小板減少症等伴隨血小板數異常之血症疾病之治療藥或預防 藥0 — 争____1----------------------- (請先閱讀背面之注意事項再填寫本頁) __ 經濟部智慧財產局員工消費合作社印製 -323- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐）

Claims (1)

1284639 月if日修Λ)正本 六、申請專利範圍 第90101355號「具有血栓形成素受體激動作用之化合 物」專利案 (2006年09月14日修正） 六申請專利範圍： 1· 一種具有血栓形成素受體激動作用之醫藥組成物，內 含有效成分爲如下式（I)化合物、其製藥容許鹽或其溶 劑化物 (I) [式中X1爲如下式基
(式中R1Q及R11各自獨立爲H、CV6院基、竣基、Ch 烷氧羰基、鹵素、呋喃基（可經i-3個鹵素、h 6院 基、C ! . 6丨兀氧基取代）、塵吩基（可經1 _ 3個鹵素、 Cm烷基、Cm環烷基、Ci 0烷氧基取代）、苯基 (可經1-4個鹵素、Ci·6烷基（可經Ci6院氧 基、苯基取代）、C!·6烷氧基（可經二Cu6烷基胺基 取代）、C!-6伸丨兀基胺基、苯基（可經_素取代）、歯 烷基、C3·6環k基、鹵c].6烷氧基、c] 6烷硫基、毗啶 1284639 六、申請專利範圍 基、- CH2CH2CH2 - 、或-〇CH2CH2 -取代）、或吲哚 基（可經Ci.6烷基取代）或共同形成伸乙基苯基（芳族環 可經<^.6烷基取代）；R12爲Η或cv6烷基）； Y1 爲一 NRAC〇一（CRcRd)0.2- 、一 NRAC〇一 CRc = C R D -、一（ c Η 2) 〇. 2 — N R a — S 〇 2 —（ C Η 2) 0.2 —、或一N R a — (CH2)G.2—(其中RA爲H; Rc及RD各自獨立爲Η、鹵 素、或CV6烷基）； Z1爲可經1-2個鹵素原子、Cle6烷基、或Cl 6烷 氧基取代之伸苯基、可經1-2個鹵素原子、Ci6烷基、 或Cl6烷氧基取代之噻吩二基； W1爲如下式基
1284639 六、申請專利範圍 R·1 R1
(式中，R、R2各自獨立爲氫原子、Ci6烷基、鹵 素、C!·6烷氧基、或苄氧基胺基；R3、R4各自獨立爲 氫原子、C!.6烷基（可經1個苯基、噻吩基、呋喃 基、Ci·6烷硫基、三氟甲基、Ci 6烷基矽烷基、Cn 院氧基、胺基（可經1個以上C !· 6烷基取代）、羧基、 C3_6環烷基取代，上述苯基、噻吩基、呋喃基可經 1個鹵素、Cu烷基、鹵Cl-6烷基取代）、c2 6 稀基、C2_6炔基、c3 6環烷基、cl6烷氧基、二 C^6院基胺基、乙醯基胺基、苯基胺基、苯基、 噻嗤基、吡啶基、或苯并噻唑基，或者共同形成 2,2-氧二伸乙基；R5、R7、r8、R9各自獨立爲氫 原子 '或烷基；R6爲嗎啉基； A1爲吡啶基（環上可經1個羧基、（:16烷氧基 羰基、或胺基取代）、苯基（環上可經1個（：1. 太兀氧基Ci-6院氧基、經基、或院基磺酿基 胺基取代）、或咪唑基； 虛線（一-)表示鍵之有或無存在）]。 2·如申請專利範圍第1項之具有血栓形成素受體激動 作用之醫藥組成物，其中X1爲如下式基
1284639 六、申請專利範圍 (式中111()及R11同申請專利範圍第1項之定義）。 3·如申請專利範圍第1項之具有血栓形成素受體激動 作用之醫藥組成物，其中Y1爲4：«(：〇-、-〇：(^11-、-NHCH2-、-NHC〇-CH = CH-、或-NHS〇2 -。 4·如申請專利範圍第1項之具有血栓形成素受體激動 作用之醫藥組成物，其中Y1爲-NHCO-。 5. 如申請專利範圍第1項之具有血栓形成素受體激動 作用之醫藥組成物，其中Z1爲可經鹵素或C i. 6烷基 取代之1，4-伸苯基。 6. 如申請專利範圍第1項之具有血栓形成素受體激動 作用之醫藥組成物，其中R1爲Η或C^.6烷基。 7. 如申請專利範圍第1項之具有血栓形成素受體激動 作用之醫藥組成物，其中R2爲Η、CV6烷基、鹵 素、〇V6烷氧基。 8·如申請專利範圍第1〜7項中任一項之具有血栓形成 素受體激動作用之醫藥組成物，其爲血小板生產調節 劑。 9· 一種如下式（II)化合物、其製藥容許鹽或其溶劑化 物， X2-Y、Z2-W2 ( Π ) [式中X2爲；如下式基
1284639 六、申請專利範圍 (式中R1。及R11各自獨立爲Η、C!.6烷基、竣基、 個_ 烷氧 烷氧羰基、鹵素、呋喃基（可經1-3個_繁 院基、C ! _ 6院氧基取代）、噻吩基（可經 素、j：兀基、C3_6環院基、（^·6院氧基取代） 苯基（可經卜4個鹵素、Cl 6烷基（可經c ' 基、苯基取代）、CV6烷氧基（可經二c 如基胺基 取代）、C^6伸烷基胺基、苯基（可經鹵素取 1〜、鹵 c丨-6烷基、c3.6環烷基、鹵Cl_6烷氧基、c 1 ·6 硫基、 吡啶基、-CH2CH2CH2_、或-〇 CH2CH2-取佧、 、J 、或吲 哚基（可經C6院基取代）或共同形成伸乙基苯基 (芳族環可經烷基取代）； Y2 爲一 NRAC〇一（CRCrd)〇 2一 、一 nrac〇〜crC = CRd-、一（CH2)〇_2 - NRA - S02 - （CH2)0.2 〜或一 nra — (CHA.r (其中RA爲H; RC及Rd各自獨立爲h、_ 素、或烷基）； Z2爲可經1-2個_素原子、C!·6院基、或ci6院氧 基取代之伸苯基、可經1-2個鹵素原子、院基、 或Cn院氧基取代之2,5-噻吩二基； W2爲如下式基 1284639 六、申請專利範圍 R1 Ο R1 Ο R1 0
R6
(式中 RhR2各自獨立爲氫原子、CV6烷基、鹵 素、Cr6烷氧基、或苄氧基胺基；R3、R4各自獨立爲 氫原子、C^6烷基（可經1個苯基、噻吩基、呋喃 基、CV6烷硫基、三氟甲基、CV6烷基矽烷基、CV6 烷氧基、胺基（可經1個以上（^_6烷基取代）、羧基、 C3_6環烷基取代，上述苯基、噻吩基、呋喃基可經 1個鹵素、Cm烷基、鹵烷基取代）、C2_6 烯基、C2_6炔基、C3.6環烷基、cv6烷氧基、二 C i _6烷基胺基、乙醯基胺基、苯基胺基、苯基、 噻唑基、吡啶基、或苯并噻唑基，或者共同形成 1284639 六、申請專利範圍 2,2-氧二伸乙基；R5、R7、R8、R9各自獨立爲氫 原子、或CV6烷基；R6爲嗎啉基； A2爲吡啶基（環上可經1個羧基、Ci 6烷氧基 簾基、或胺基取代）、苯基（環上可經1個c丨-6 文兀氧基Ci.6烷氧基、羥基、或（^.6烷基磺醯基 胺基取代）、或咪唑基； 虛線（一-)表示鍵之有或無存在）]。 10.如申請專利範圍第9項之化合物、其製藥容許鹽或 其溶劑化物，其中X2爲如下式基
(式中 R16爲Η、CV6烷基； R17、 R18、 R19、 R2。、 R21、 R22、及 R23 各 自獨立爲Η、可有一個以上選自下述取代基群B取 代之CV6烷基、C3.6環烷基、可有一個以上選自下 述取代基群B取代之烷氧基、Cle6烷硫基、或 鹵素； 取代基群B:CV6烷氧基、鹵素、可經cv6烷基取 代之胺基、或苯基； R16 及 R17 可共形成-CH2·、-CH2CH2-、或-CH2CH2CH2-。 1284639 六、申請專利範圍 11. 如申請專利範圍第9項之化合物、其製藥容許鹽或 其溶劑化物，其中Y1爲-NHCO-。 12. 如申請專利範圍第9項之化合物、其製藥容許鹽或 其溶劑化物，其中Z2爲可經鹵素或（^.6烷基取代之 1，4 -伸苯基。 13. 如申請專利範圍第9項之化合物、其製藥容許鹽或 其溶劑化物，其中R1爲Η或C i .6烷基。 14. 如申請專利範圍第9項之化合物、其製藥容許鹽或 其溶劑化物，其中R2爲Η、CV6烷基、鹵素、或（V 6院氧基。 15. 如申請專利範圍第9項之化合物、其製藥容許鹽或 其溶劑化物，其中W2爲如下式基
(式中 R1，R2, R3, R4, R5, R6，R7，R8 及 A2 同申請專利 範圍第9項之定義）。 16.如申請專利範圍第9項之化合物、其製藥容許鹽或 其溶劑化物，其爲式（III)化合物 1284639 六、申請專利範圍
18 R17、 R--、 is. ，/χχν TT 口 卿且㈣ n、*gj 有一個以上選自下述取代基群B取代之<^.6烷_、 (IH) R19、 R2Q、及R21各自獨立爲Η、 C3.8環烷基、可有一個以上選自下述取代基群B取代 之（^卜6院氧基、Cn院硫基、鹵素、或本基； 取代基BiCpe烷氧基、鹵素可經烷基取代之胺 基、及苯基； R16及 R17也可共形成-CH2-、-CH2CH2•、或 -CH2CH2CH2·; R31及R32各自獨立爲H、CV6烷基、鹵素、或Cy 烷氧基； W3爲如下式基
(式中R 爲Η、基、院氧基、或齒素； R14及R15各自獨立爲Η、或各爲選自下述取代基a 所取代之C!.6烷基、C3.6環烷基、苯基，苯基爲可 I284639
六、申請專利範圍 ，键幽素或鹵c1-6烷基取代之苯基- Cl_6烷基、吡 D定基、異噻唑基、呋喃基-C1.6烷基、或噻吩基-C 1 - 6烷基； 取代基群A:鹵素、可經Cl.6烷基取代之胺基、羧 基、C】·，烷硫基、Cl.6烷基矽烷基、或（^.6烷氧基； R24爲Η或CU6烷基； R25爲嗎啉基； A3爲吡啶基（環上可經1個羧基、c 1.6烷氧基 鑛基、或胺基取代）、苯基（環上可經1個CV6 院氧基CV6烷氧基、羥基、或Cl_6烷基磺醯基 胺基取代）、或咪唑基。 17·如申請專利範圍第9項之化合物、其製藥容許鹽或 其溶劑化物，其爲式（IV-A)化合物
[式中R27爲H、CV3烷基、三氟甲基、或鹵素； R28、R29、及R3G各自獨立爲Η、可有一個以上選 自下述取代基群Β取代之CV6烷基、C3_6環烷基、可 有一個以上選自下述取代基群B取代之C 烷氧基、 cu6烷硫基、鹵素、苯基、或吡啶基； 取代基群烷氧基、鹵素或苯基； R31及R32各自獨立爲H、CV6烷基、鹵素、或CV -10- 1284639 六、申請專利範圍 烷氧基； W4爲如下式基
(式中 R13爲Η、cv6烷基、CV6烷氧基、或鹵素； R14及R15各自獨立爲H、或各可有選自下述取代 基群A取代之（^.6烷基、C3.6環烷基、苯基，苯基爲 可經鹵素或鹵烷基取代之苯基-Cm烷基，吡啶 基、異噻唑基、呋喃基-Ch6烷基，或噻吩基-Cu6 烷基； 取代基群 A:鹵素、鹵院基、院硫基、 Cu烷基矽烷基、或Ci_6烷氧基； R24爲Cb6烷基。 18.如申請專利範圍第9項之化合物、其製藥容許鹽或 其溶劑化物，其爲式（IV-B)化合物
[式中R28、R29、及R3G各自獨立爲Η、或Cm烷基； R3]及R32各自獨立爲H、或Cm烷基； W4爲如下式基 -11- 1284639 六、申請專利範圍
(式中 R13爲Η、〇ν6烷基、Ci.6烷氧基、或鹵素； R14及R15各自獨立爲Η、或各可經選自下述取代基 群Α取代之Cm烷基、C3.6環烷基、苯基，苯基爲 可經鹵素或鹵烷基取代之苯基烷基，吡啶 基、異噻唑基、呋喃基-(^.6烷基，或噻吩基 院基； 取代基群A:鹵素、可經（^.6烷基取代之胺基、羧 基、C ! . 6院硫基、c i . 6院基砂院基、或C i _ 6院氧基； R24爲CV6烷基）； τ 爲-CH2-、-CH2CH2-、或-CH2CH2CH2-]。 19·〜種具有血栓形成素受體激動作用之醫藥組成物，內 含如申請專利範圍第9〜1 8項中任一項之化合物爲有 效成分。 2〇·〜種血小板生產調節用之醫藥組成物，內含如申請專 利範圍第9〜1 8項中任一項之化合物爲有效成分。 -12-
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