1281380 玖、發明說明 [發明所屬之技術領域] 本發明係有關於可降低香煙之主流煙中的駿類含量 香煙過濾器。 3里之 [先前技術] 抽煙者抽煙時吐出的主流煙中含有各種化學成分。此 等化學成分當中由甲醛所代表的醛類難以利用普通的香煙 過濾器吸收並移除。因此，欲自香煙的主流煙移除醛類。 過去企圖於香煙過濾器中使用各種添加物以吸收並移 除香煙的主流煙中所含㈣類。’然而，使用習知的添加: 將引起減弱菸草味道的問題。 [發明内容] 本發明之一目的在提供一種香煙過濾器，該香煙過濾 裔旎有效地降低香煙的主流煙中的醛類含量同時抑制如菸 草味道減弱的不利影響。 根據本發明的目的之香煙過濾器的特徵為包括含鹼性 月女基fee或驗性胺基酸鹽及保渥劑的過濾器介質。 用於本發明之鹼性胺基酸或鹼性胺基酸鹽係選自由精 胺酸、精胺酸鹽、離胺酸、離胺酸鹽、組胺酸、組胺酸鹽7 鳥胺I、鳥胺酸鹽、瓜胺酸、瓜胺酸鹽、羥嗪及羥嗪鹽所 構成的組群。用於本發明的保溼劑係選自由甘油、丙酸納 及乳酸納所構成之組群。 本發明的香煙過濾器中，所需的鹼性胺基酸或鹼性胺 基酸鹽之含I為3.5rng或更多。 5 3】5057 1281380 本發明的香煙過濾器中，所需的鹼性胺基酸或鹼性胺 基酸鹽對保渔劑之比例介於1 : 1及1 : 2之間。 [實施方式] 由各種觀點對添加物導入深入的研究以降低香煙的主 流煙中所含之醛類的結果，發明人發現鹼性胺基酸或驗性 胺基酸鹽為有效的添加物。本發明所用的鹼性胺基酸或鹼 性胺基酸鹽係選自由，例如，精胺酸、精胺酸鹽、離胺酸、 離胺酸鹽、組胺酸、組胺酸鹽、鳥胺酸、鳥胺酸鹽、瓜胺 酸、瓜胺酸鹽、經嗪及經嗪鹽所構成的組群。此等化合物 當中’精胺酸及其鹽類經認可為食物添加物。 %明人亦發現若驗性胺基酸或驗性胺基酸鹽與保渥劑 結合使用將可更有效地移除香煙的主流煙中所含的醛類。 用於本發明的保溼劑係選自甘油、丙酸鈉及乳酸鈉所構成 的組群。 可使用如醋酸麻纖、紙過濾材或黏漿不織布之普通過 滤益介質作為鹼性胺基酸或鹼性胺基酸鹽及保溼劑的 (過濾器原料）。 丑 咸相信，在本發明的香煙過濾器中，香煙的主流煙中1281380 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明 发明3 [Previous technology] The mainstream smoke emitted by smokers when they smoked contains various chemical components. The aldehydes represented by formaldehyde among these chemical components are difficult to absorb and remove using ordinary cigarette filters. Therefore, it is desirable to remove aldehydes from the mainstream smoke of cigarettes. Classes (4) contained in mainstream smoke that attempted to absorb and remove cigarettes in cigarette filters in the past. 'However, using conventional additions: will cause problems that weaken the taste of tobacco. SUMMARY OF THE INVENTION An object of the present invention is to provide a cigarette filter which effectively reduces the aldehyde content in the mainstream smoke of cigarettes while suppressing the adverse effects such as the weakening of the taste of tobacco. A cigarette filter according to the object of the present invention is characterized by comprising a filter medium comprising an alkaline moon-based fee or an amido acid salt and a sputum. The basic amino acid or basic amino acid salt used in the present invention is selected from the group consisting of arginine, arginine, lysine, lysine, histidine, histamine 7 avian amine I a group consisting of aguanine, citrulline, citrulline, hydroxyzine and hydroxyzine salts. The humectant used in the present invention is selected from the group consisting of glycerin, sodium propionate and sodium lactate. In the cigarette filter of the present invention, the desired basic amino acid or basic amino acid salt has an I content of 3.5 rng or more. 5 3] 5057 1281380 In the cigarette filter of the present invention, the ratio of the required basic amino acid or basic amino acid salt to the fishery agent is between 1:1 and 1:2. [Embodiment] From the viewpoint of introducing an additive into various studies to reduce the results of the aldehydes contained in the main stream of cigarettes, the inventors have found that a basic amino acid or an amphoteric acid salt is an effective additive. The basic amino acid or basic amino acid salt used in the present invention is selected from, for example, arginine, arginine, lysine, lysate, histidine, histidine, bird a group consisting of aminic acid, aguanine, citrulline, citrulline, a azine, and a salt. Among these compounds, 'arginine and its salts are recognized as food supplements. % Ming also found that the combination of an a test amino acid or an a test amine salt with a herbicide would more effectively remove the aldehydes contained in the mainstream smoke of cigarettes. The humectant used in the present invention is selected from the group consisting of glycerin, sodium propionate and sodium lactate. A filter medium such as a cellulose acetate, a paper filter or a non-woven fabric can be used as a basic amino acid or a basic amino acid salt and a humectant (filter material). Ugly, I believe that in the cigarette filter of the present invention, the mainstream smoke of cigarettes
本發明的香煙過濾器中， 而降低。第一步驟，香煙 濾器承載之保溼劑所保持 I類與過:慮杰承載之驗性 而捕集於過濾器内。要注意 鹼性胺基酸或鹼性胺基酸鹽 315057 6 1281380 的含置應為3 · 5mg或更多，因為含量小於3 · 5 mg時將難以 獲得充分降低醛類的效果。 另外，本發明的香煙過濾器中，指定鹼性胺基酸或鹼 性胺基酸鹽對保溼劑的比例要落於1 : 1至1 : 2之間。若 上述比例並未落於上述範圍内，將難以獲得充分降低醛類 的效果。 為使過濾裔介質含有驗性胺基酸或驗性胺基酸鹽及保 渔劑，可使用如噴佈、浸潰及輥輪轉印的方法。 除了鹼性胺基酸或鹼性胺基酸鹽及保溼劑之外，過淚 器介質亦可包含活性碳。 香煙濾嘴的結構可為普通型、兩段型、含三或更多段 的多段型或填塞物-間隔-填塞物型。鹼性胺基酸或鹼性胺 基酸鹽及保溼劑可含於香煙濾嘴之部分或所有區段。 本發明的香煙過濾器可為連結至香煙的菸草段作為口 含末端組件或呈煙嘴形式的過濾器。 實施例·· 在以下實施例所用之香煙主流煙中所含的酸類之測量 方法中，以高速液相層析法（HPLC)測量2,4-二硝基苯讲 (DNPH)的衍生物、捕集物質。可以此方法同時測量的物質 為甲醛、乙醛、丙酮、丙烯醛、丙醛、丁烯醛、曱乙酮及 正丁嗣所構成之8種組成分。以下的實施例中，說明將指 向所要測量的醛類（羰基化合物）當中的甲醛。 第一步驟中，捕集溶液係藉由將9.5 1 g的2,4-二破基 苯肼（DNPH)溶於1 L的乙腈中，接著添加5.6niL的60%過 315057 7 1281380 氯酸然後利用超純水將得到的溶液稀釋至2乙。 測量裝置的構造參照第i圖加以說明。如第】圖所示， 將DNPH捕集溶液12置於Drechsel型捕集器“中。 Drechsel型捕集器11具有25〇mL的内部體積，捕集 溶液的量為lOOmL，無效體積為15〇mL。將型捕 集器11置於冰水浴13巾冷卻。將香煙！裝在其頂端的玻 璃管14下端浸入Drechsel型捕集器u内的捕集溶液12 中。再者’裝没玻璃管15及Cambridge墊16俾與Drechsel 型捕集器11的無效體積相連，並將自動抽煙機17連至 Cambridge 墊 1 6 〇 將香煙1裝到玻璃管14俾於ISO標準所指定的標準 抽煙條件下自動地吸取香煙i。更明確地說，一支香煙以 每口兩秒吸35mL的煙重複進行58秒的時間。當主流煙發 出氣泡時，8種羰基化合物的組成分將轉變成DNpH的衍 生物。該測量使用兩支香煙。 以HPLC測夏由此形成的衍生物。第一步驟中，過滅 捕集溶液’接著利用Trizma Base溶液（4mL的捕集、、容、夜· 6mL的Trizma Base溶液）稀釋濾出的捕集溶液。然後，以 HPLC測量稀釋溶液。HPLC的測量條件如下： 管柱：HP LiChrospher 100ΓΙΡ-18(5μ)250 X 4 mm ; 防護管柱·· HP LiChrospher 100ΙΙΡ-18(5μ)4 x 4 mm · 管柱溫度：30eC ; 偵測波長：DAD 356nm ; 注射量·· 20 μι ; 315057 8 1281380 移動相：含3個相的梯度 (溶液A :含3〇%乙腈、1〇%四氫呋喃及1%異丙醇（ipA)之 超純水溶液；溶液B ··含65%乙腈、1%四氫呋喃及1%異 丙醇之超純水溶液；溶液C : 1 〇0%乙膳）。 參照第2圖所示的剖面圖示說明用作樣品的香煙結 構。如第2圖所示，香煙含有利用捲煙紙22捲包切細的菸 草21的菸草段20，以及利用成形紙32捲包過濾器3丨的 過濾器段30。用水松紙40將過濾器段3〇連至菸草段2〇。 在使用添加驗性胺基酸或驗性胺基酸鹽及保溼劑的試 驗過濾器製備的香煙時，自市面上可購得的6111卜焦油香煙 切下醋酸醋過濾裔而取出煙草段，將該煙草段連到試驗過 濾器以提供樣品。使用噴霧器將鹼性胺基酸或鹼性胺基酸 鹽及保溼劑加至試驗過濾器。 試驗1 : 製備作為基礎過濾器之25mm-長的醋酸酯過濾器。另 外，使基礎過濾器包含6.5mg的水以製備對照用的試驗過 濾器。再者，使基礎過濾器包含6.5mg的水及35mg的添 加物以製備試驗過濾器。該添加物係選自由L_精胺酸、精 穀胺酸（arginine glutamate) > 曱酸醯肼（hydrazide formate)、氨、乙醯胺及尿素所構成的組群，歸類為含氮 的驗性物質。 各過濾器皆連到上述的菸草段以製備香煙樣品，由上 述測量方法測量每支香煙主流煙中的曱醛輸送量（咫/香 煙）。第3圖為嘁示結果的圖形。與基礎過濾器僅包含水份 315057 9 1281380 的情形相比’第3圖顯然能支持鹼性胺基酸中的精胺酸 及鹼性胺基酸鹽中的精穀胺酸對於降低甲醛的輸送量特別 有效的結果。 意外地發現到，為了降低曱醛的輸送量，過濾器中 精胺酸或精穀胺酸的量較佳為3 5mg或更多。 試驗2 : 使基礎過濾器包含L-精胺酸及不同的水量。將水含量 各不相同的過濾态連至上述的於草段以製備香煙樣品，以 上述測量方法測量每支香煙主流煙中的甲醛輸送量（陴/香 煙）。第4圖為顯示結果的圖形。由第4圖顯然可見，在過 濾器含3.5mg L-精胺酸的情形中，若過濾器中的水份為 5mg或更多則可有效地降低主流煙中的甲醛。 試驗3 : 使基礎過濾器包含L-精胺酸及用作保溼劑之甘油以 檢查過濾為中增加的水量。將精胺酸含量設定於3 5 mg、7.0mg或l〇.5mg。將甘油含量設定於18吨或52叫。 乐5圖為顯示結果的圖形。帛5圖顯然能支持過濾器所保 持的水份含量會隨著保溼劑，亦，甘油，的用量增加而 増加的結果。 試驗4 : 使基礎過濾态僅含有3 5mg的L•精胺酸以製備不含保 漣劑之對照用的試驗過濾器。另外，使基礎過濾器包含 3.5mg的L-精胺酸及保溼劑以製備試驗過濾器。保溼劑係 逆自由甘油、木糖醇、泛酸鈉、吡咯烷酮羧酸鈉（pca ίο 3]5057 1281380 鈉）、乳酸鈉、丙酸鈉、DL_蘋果酸鈉' D_甘露糖及氯化鈣 :構成之組群。將各試驗過濾器連至上述菸草段以製備香 於樣品’以i述測量方法測量每支香煙主流煙中的曱醛輸 送量香煙）。第6圖為顯示結果的圖形。由第6圖顯然 可見，與使基礎過濾器僅包含L_精胺酸的情形相比，用作 ，溼劑的甘油、乳酸鈉及丙酸納能有效地降低甲駿的輸送 里。就過濾器的製造過程而·^ ’此等保溼劑皆係適宜的。 試驗5 : 製備不同的試驗過濾器，其中基礎過濾器包含3 的L-精胺酸及不同量之作為保澄劑的乳酸納。將乳酸鈉對 L-精胺酸的比例設定於1 ·· 1i ·· 2或} ·· 3。 使各试驗過濾裔連至上述的菸草段以製備香煙樣品， 以上述測量方法測量每支香、煙主流、煙中的曱醛％送量⑽ 香煙）。第7圖為顯示結果的圖形。由第7圖能支持使美礎 過滤器包含比例為1: 1或1:2之L-精胺酸與乳酸時^可 有效地降低主流煙中的曱醛輸送量的結果。 本發明的香煙過濾器可有效地降低香煙的主流煙中所 含的甲醛含量。 [圖式簡單說明] 第1圖概略地顯示用於測量本發明之實施例的香煙主 流煙中所含的甲酸之裝置的結構； 第2圖為顯示本發明之實施例中所用的香煙之結構的 剖面圖示； 弟3圖為顯不視添加至香煙過濾器的鹼性物質類型而 315057 1281380 定之甲醛運送圖形； 第4圖為顯示與L-精胺酸一起添加至香煙過濾器的水 量與甲醛運送之間的關係圖； 第5圖為顯示與L-精胺酸一起添加至香煙過渡器的甘 油用量與香煙過濾器中增加的水量之間的關係圖； 第6圖為顯示視與L-精胺酸一起添加至香煙過濾器的 保溼劑類型而定之曱醛運送圖；以及 弟7圖為頒不添加至香煙過渡為的L -精胺酸對甘油之 比例與甲醛運送之間的關係圖。 1 香煙 11 Drechsel型捕集器 12 捕集溶液 13 冰水浴 14 玻璃管 15 玻璃管 16 Cambridge 塾 17 自動抽煙機 20 菸草段 21 切細的於草 22 捲煙紙 30 過濾器段 3 1 過濾器 32 成形紙 40 水松紙 12 315057In the cigarette filter of the present invention, it is lowered. In the first step, the humectant carried by the cigarette filter is kept in the filter and kept in the filter. It is to be noted that the basic amino acid or basic amino acid salt 315057 6 1281380 has a content of 5.3 mg or more, since it is difficult to obtain an effect of sufficiently reducing the aldehyde when the content is less than 3.5 mg. Further, in the cigarette filter of the present invention, the ratio of the basic amino acid or the basic amino acid salt to the humectant is specified to be between 1:1 and 1:2. If the above ratio does not fall within the above range, it will be difficult to obtain an effect of sufficiently reducing the aldehyde. In order to allow the filter medium to contain an amino acid or an amine salt and a fishery agent, a method such as spraying, dipping, and roller transfer can be used. In addition to the basic amino acid or basic amino acid salt and humectant, the teardrop media may also contain activated carbon. The structure of the cigarette filter may be a normal type, a two-stage type, a multi-stage type containing three or more stages, or a stuffer-spacer-filler type. The basic amino acid or basic amine acid salt and humectant may be contained in some or all of the sections of the cigarette filter. The cigarette filter of the present invention may be a tobacco segment attached to a cigarette as a mouth-end assembly or a filter in the form of a mouthpiece. EXAMPLES · In the measurement method of the acid contained in the mainstream cigarette of the cigarette used in the following examples, the derivative of 2,4-dinitrobenzene (DNPH) was measured by high performance liquid chromatography (HPLC). Capture material. The substances which can be simultaneously measured by this method are eight components consisting of formaldehyde, acetaldehyde, acetone, acrolein, propionaldehyde, crotonaldehyde, acetophenone and n-butyl fluorene. In the following examples, the description will be directed to formaldehyde in the aldehyde (carbonyl compound) to be measured. In the first step, the trapping solution was prepared by dissolving 9.5 1 g of 2,4-dihydrobenzoquinone (DNPH) in 1 L of acetonitrile followed by 5.6 niL of 60% of 315057 7 1281380 chloric acid. The resulting solution was diluted to 2 B with ultrapure water. The configuration of the measuring device will be described with reference to Fig. i. As shown in the figure, the DNPH trap solution 12 is placed in the Drechsel type trap. The Drechsel type trap 11 has an internal volume of 25 〇mL, the amount of the trapping solution is 100 mL, and the ineffective volume is 15 〇. The model trap 11 was placed in an ice water bath to cool the towel. The lower end of the glass tube 14 at the top of the cigarette was immersed in the trap solution 12 in the Drechsel type trap u. 15 and the Cambridge mat 16俾 are connected to the ineffective volume of the Drechsel type trap 11, and the automatic smoking machine 17 is connected to the Cambridge mat 1 6 〇 The cigarette 1 is attached to the glass tube 14 under the standard smoking conditions specified by the ISO standard. Automatically draw cigarettes i. More specifically, a cigarette is repeated for 35 seconds by taking 35 mL of smoke per second for two seconds. When mainstream smoke emits bubbles, the composition of the eight carbonyl compounds will be converted to DNpH. The measurement uses two cigarettes. The derivative thus formed is determined by HPLC. In the first step, the trapping solution is used, and then the Trizma Base solution is used (4 mL of trap, volume, night, 6 mL of Trizma). Base solution) Dilute the filtered capture solution. The diluted solution was measured by HPLC. The HPLC conditions were as follows: Column: HP LiChrospher 100ΓΙΡ-18 (5μ) 250 X 4 mm; Protective column · HP LiChrospher 100ΙΙΡ-18(5μ) 4 x 4 mm · Column temperature : 30eC ; Detection wavelength: DAD 356nm ; Injection volume · · 20 μι ; 315057 8 1281380 Mobile phase: gradient with 3 phases (solution A: containing 3〇% acetonitrile, 1〇% tetrahydrofuran and 1% isopropanol ( Ultra pure aqueous solution of ipA); solution B · ultra-pure aqueous solution containing 65% acetonitrile, 1% tetrahydrofuran and 1% isopropanol; solution C: 1 〇 0% ethyl). Refer to the sectional view shown in Fig. 2 The cigarette structure used as a sample is illustrated. As shown in Fig. 2, the cigarette contains a tobacco section 20 in which the shredded tobacco 21 is wrapped with a cigarette paper 22, and a filter section 30 in which the filter 3 is wrapped by the forming paper 32. The filter section 3 is connected to the tobacco section 2 by using a tipping paper 40. When using a test filter prepared by adding an experimental amino acid or an experimental amine acid salt and a moisturizing agent, it is commercially available. Purchased 6111 tar cigar cigarettes, cut the acetic acid vinegar filter and removed the tobacco segment, and connected the tobacco segment to the test filter. To provide a sample, a basic amino acid or a basic amino acid salt and a humectant were added to the test filter using a sprayer. Test 1: A 25 mm-long acetate filter was prepared as a base filter. The base filter contained 6.5 mg of water to prepare a test filter for comparison. Further, the base filter was made to contain 6.5 mg of water and 35 mg of an additive to prepare a test filter. The additive is selected from the group consisting of L_arginine, arginine glutamate > hydrazide formate, ammonia, acetamide and urea, classified as nitrogen-containing Test substances. Each of the filters was attached to the above-mentioned tobacco section to prepare a cigarette sample, and the amount of furfural transport (咫/smoke) in the mainstream smoke of each cigarette was measured by the above measurement method. Figure 3 is a graph showing the results. Compared with the case where the base filter contains only water 315057 9 1281380, 'Fig. 3 clearly supports the arginine in the basic amino acid and the refined glutamic acid in the basic amino acid salt to reduce the transport of formaldehyde. A particularly effective result. It has been unexpectedly found that the amount of arginine or refined glutamic acid in the filter is preferably 35 mg or more in order to reduce the amount of furfural transported. Test 2: The base filter contains L-arginine and a different amount of water. A filtration state in which the water contents are different is connected to the above-mentioned grass segment to prepare a cigarette sample, and the amount of formaldehyde transport (陴/smoke) in the mainstream smoke of each cigarette is measured by the above measurement method. Figure 4 is a graph showing the results. As is apparent from Fig. 4, in the case where the filter contains 3.5 mg of L-arginine, if the water content in the filter is 5 mg or more, the formaldehyde in the mainstream smoke can be effectively reduced. Test 3: The base filter was made to contain L-arginine and glycerin used as a humectant to check the amount of water added to the filtration. The arginine content was set at 35 mg, 7.0 mg or 10 mg. Set the glycerin content to 18 tons or 52 calls. The music 5 picture is a graphic showing the result. The 帛5 diagram clearly supports the result that the moisture content of the filter increases with the amount of humectant, glycerin, and the like. Test 4: The base filtration state contained only 35 mg of L•arginine to prepare a test filter for the control without the herbicide. Further, the base filter was made to contain 3.5 mg of L-arginine and a humectant to prepare a test filter. The humectant is anti-free glycerol, xylitol, sodium pantothenate, sodium pyrrolidonecarboxylate (pca ίο 3]5057 1281380 sodium), sodium lactate, sodium propionate, DL_sodium malate 'D_mannose and calcium chloride: The group that constitutes. Each of the test filters was attached to the above-mentioned tobacco section to prepare a sample of the sample which was measured by the measurement method to measure the amount of furfural in each mainstream cigarette. Figure 6 is a graph showing the results. As is apparent from Fig. 6, the use of glycerin, sodium lactate and sodium propionate as a wet agent can effectively reduce the transport of the junta compared to the case where the base filter contains only L_arginine. These moisturizers are suitable for the manufacturing process of the filter. Test 5: Different test filters were prepared in which the base filter contained 3 L-arginine and varying amounts of sodium lactate as a preservative. The ratio of sodium lactate to L-arginine is set to 1 ·· 1i ·· 2 or}·· 3 . Each test filter was connected to the above tobacco segment to prepare a cigarette sample, and each of the fragrance, the smoke mainstream, and the furfural % (10) cigarette in the smoke were measured by the above measurement method. Figure 7 is a graph showing the results. The results of Figure 7 can support the use of L-arginine and lactic acid in a ratio of 1:1 or 1:2 to effectively reduce the amount of furfural transport in mainstream smoke. The cigarette filter of the present invention can effectively reduce the formaldehyde content contained in the mainstream smoke of cigarettes. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a view schematically showing the structure of an apparatus for measuring formic acid contained in cigarette mainstream smoke according to an embodiment of the present invention; and Fig. 2 is a view showing the structure of a cigarette used in an embodiment of the present invention. The cross-sectional illustration; Figure 3 shows the type of alkaline substance added to the cigarette filter and the formaldehyde delivery pattern of 315057 1281380; Figure 4 shows the amount of water added to the cigarette filter together with L-arginine Diagram of the relationship between formaldehyde delivery; Figure 5 is a graph showing the relationship between the amount of glycerol added to the cigarette transition device together with L-arginine and the amount of water added in the cigarette filter; Figure 6 is a view showing L and L - urinary acid is added to the type of humectant of the cigarette filter depending on the type of hydrazine transport; and Figure 7 is between the ratio of L-arginine to glycerol that is not added to the transition of cigarettes and the transport of formaldehyde relation chart. 1 Cigarette 11 Drechsel trap 12 Capture solution 13 Ice bath 14 Glass tube 15 Glass tube 16 Cambridge 塾17 Automatic smoking machine 20 Tobacco section 21 Shredded grass 22 Cigarette paper 30 Filter section 3 1 Filter 32 Forming Paper 40 tipping paper 12 315057