1267392 九、發明說明： 【發明所屬之技術領域】 本發明係有關於-種用於光動力治 具有區域範圍内照度均句之優點，針對臉部t;膚二 射2ft利用充發光二極體排列的方 置均勻度提高。 而且“知之傳統光動力照射裝 【先前技術】 光動力療法（Photo-Dynamic Therapy，_又稱光照 射療法，其基本原理就是先用光感物質來標*腫瘤細胞， 再用強光或雷射光照射，強光或雷射光與腫瘤細胞或腫瘤 組織中的光感物質（光敏物質）發生光化學作用，在光感^ 質所在的位置造成細胞毒性，殺滅腫瘤細胞（如癌細胞）。 PDT診治人體腫瘤，必須具備三個因素··（1)在腫瘤組 織中含有一定濃度的光敏物質；（2)腫瘤組織中含有分子狀 怨的氧，（3)適當波長的光。臨床上選用的光敏劑必須具備 以下條件：1對人體基本上無毒性；2注入人體後能選擇性 地貯留在腫瘤組織中，而在短時期内從正常組織中被排泄 掉；3能被一定波長的光所啟動。所選用的激勵光源應該 和光敏劑相適應，即其波長能啟動該光敏劑，而且這種波 長的光應能穿透一定深度的人體組織。根據實驗研究，光 敏劑中的大聚合物是PDT #治癌症的主要成份。有人認爲 當光敏劑注入人體後，開始時光敏劑可以通過微血管系統 進入正常組織和腫瘤組織，但由於腫瘤組的淋巴回流系統 不像正常組織的淋巴系統健全，因此這些大聚合物在腫瘤 中貝τ留的時間要比正常組織長。光敏劑有一種非常強的、 1267392 甚至能在血清中和大聚合物進行自我結合的傾向（分子量 達6000 ’和白蛋白的大小相似）。這些聚合物有可能和其 他血清組分一起漏到腫瘤間質的液體中長期停留，並緊緊 地結合在腫瘤組織表面，然後逐漸分離而和腫瘤細胞成分 主要是和腫瘤細胞膜等結合。經過一定時間，腫瘤周圍的 光敏劑基本上被排泄掉，但腫瘤中仍貯留相當濃度的光敏 劑’在此時進行光照，就會使m織發射螢光或破壞腫 瘤。並且作爲一種選擇性治療的必要條件，它們在血清中 被清除後不能繼續貯留在腫瘤内。 、，在習知的光動力療法中，在皮膚表面治療裝置方面， 如美國專利US5660461當中列舉了一種平面二極體矩陣， 明參考第一圖所示之光動力療法裝置la，具有發光體固定 機架10a，其上具有複數個發光體12a(可為發光二極體） 以矩陣方式排列，且每一發光體12a皆有反光罩14a用以 ♦光，该習知技術雖然有光均勻分佈的矩陣構造配合每一 發光體12a都有的反光罩14a，但是其反光罩i4a構造過 於繁複眾多’造成該光動力療法裝置la組裝不便且成本增 咼’因為要製造構造精密的發光體固定機架l〇a必須考慮 製造程序或相關治具的成本，且反光罩的使用其實有過度 設計（over design)的狀況，因為在實際照射皮膚做治療 時，並無必要對每一點光源做區域聚光，因為多餘的射計 意味著製造成本的提高，因此上述習知技藝具有極大的改 善空間，如簡化反光罩14a及簡化發光體固定機架1〇a， 最好是能使用電子工業中最常見的發光二極體LED之封裝 方式，及用簡單的固定機架來固定發光二極體，如此一來 大量生產可使得光動力療法不再是少數病患的特權，而能 1267392 形成大眾化價格而廣泛利用於皮膚腫瘤相關疾病。 在習知的發光二極體放射裝置中，在平面能量放射萝 置方面，如美國專利US5278432當中列舉了一種平面二= 體矩陣，雖非指定專用於光動力療法，亦有一定之參考價 值，請參考第二圖所示之發光二極體放射裝置lb，具有一 極體固定機座i〇b，其上具有複數個發光二極體12b以矩 陣方式排列，且每一發光二極體12b皆有電路14b用以控 制發光，該習知技術雖然有光均勻分佈的矩陣構造配合^ 一發光二極體12b連接的電路i4b，且其二極體固定機座 10b可為具有一印刷電路板結合相關電子零件組合而成， 與第一圖的裝置相比，發光二極體放射裝置lb具有易於組 裝（發光二極體12b直接放在具印刷電路板之二極體固定 機座i〇b上）的優點，但二極體固定機座1〇b邊緣的光照射 亮度較低為其缺點，使得上述f知技藝亦具有極大的改善 空間’因此軸本習知技藝有應用職佳 裝方式#在用於光動力療法時亦需加以改構 造，但其易組装特性可用於光動力療法之照射裝置，使ί 用於新應用領域（專門針對皮膚照射的光動力療 t H 广市面上大部分對皮膚之光動力療法而 ;句的光置，需要大面積及照射 導致發明人經努力研發出上::：成本製造及使用方便’ 【發明内容】 χ本务月來達成上述之需求。 本發明之主要目的在 造而能維持均勻昭 叙^種構造簡單，具有易製 之先動力療法光源裝置之構造，及其 1267392 專業型構造構造需符合面部曲線以方便照射，可用於皮膚 腫瘤，可以提供高品質之醫療效果特性。並且其控制電^ 可為電流或電壓之調整以使光源裝置的亮度得以調整，方 便用於不同需求光動力療程。 為了達成上述目的，本發明提供一種以發光體固定基 座（可包含印刷電路板及該印刷電路板具一平面可黏著發 光二極體之能力）安排矩陣式分佈之紅光二極體與藍光二 極體，加上矩陣邊緣以反光罩反光（調整光均勻度）或發光 二極體以矩陣外侧窄間隔距離配合矩陣内侧間隔寬距離 (另一種調整光均勻度之方法）為主要構造，配合傳統電子 裝置製程及週邊設備，而發展出本發明。 本發明構造包含··一發光體固定基座；複數個紅光發 光體，以一矩陣分佈方式設於該發光體固定基座上；及複 數個監光發光體’以另一矩陣分佈方式設於該發光體固定 基座上；當該紅光發光體或該鼙光發光體之排列規則為以 一定間隔形成一單位面積具一特定範圍内之分佈數量時， 该發光體固定基座邊緣具光反射面；當該紅光發光體或該 監光發光體之排列規則為内側部排列以預定寬距離而邊緣 側以預定窄距離時，該發光體固定基座邊緣不具光反射面。 為了使貴審查委員能更進一步暸解本發明之特徵 及技術内容’請參閱以下有關本發明之詳細說明與附圖， 然而所附圖式僅提供參考與說明用，並非用來對本發明加 以限制者。 【實施方式】 本發明分為攜帶型（p〇rtable)及專業型 (Professional)設計，會影響光照度的能量分佈的因素有： 1267392 LED與照射面的距離、LED的輻射分佈、led的光功率大小 (操作電流及溫度）、LED的排列分佈、邊緣增加反射面的 設計以及使用diffuser等，這些都會影響照射面的光強度 分佈。 本發明採用紅藍光發光二極體（LED)同時以矩陣分佈 方式設計’其原理依據 British Journal of Dermatology 皮膚學2000:142:973-978所發表有關紅、藍光併用的醫療 應用顯示：藍光（415nm)與紅光（660nm)併用可治療輕微 至中度嚴重的青春痘（acne vulgaris)，療程三個月。藍 光LED光譜範圍内包括了 9%在紫外光範圍，具殺菌效果 (anti-bacterial action)，且不會殺傷皮膚。照射量：4. 23 mW/cm2 ，每天15分鐘，累計320 J/cm2。而紅光具抗發 炎效果（anti-inflammatory action)，照射量：2 67 mW/cm2 ，每天15分鐘，累計202 J/cm2。其每平方公 分的光功率分佈為2· 67 mW/cm2至4· 23 mW/cm2之間，光 動力療法中的每次療程的劑量（dose)是以累積的能量為基 準，故光功率分佈越強則照射時間越短。 本發明之研發標的是設計一個具有雙波長照射的光動 力療法的設備，具有雙波長紅、藍光。以下將針對不同需 求的系統雛型做設計及因應不同規格的L E D所排出的陣列 作一完整的模擬及設計。除了設計局部使用的光動力療法 的設備外，也設計專業使用的全罩式設備，可因應不同的 要求來更改參數以達到系統需求。 請參考以下之名詞及單位： 幸画射流量（Radiant Flux): 1267392 〜流明 〜焦耳 / 秒/ sec) 幸畐射強度（Radiant intensity)1267392 IX. Description of the invention: [Technical field to which the invention pertains] The present invention relates to the advantage of having a region-wide illuminance uniform sentence for photodynamic therapy, for a face t; a skin two-shot 2 ft using a charge-emitting diode The squareness of the arrangement is increased. And "Knowledge of traditional light-powered radiation equipment [previous technology] Photodynamic therapy (Photo-Dynamic Therapy, _ also known as light irradiation therapy, the basic principle is to use the light-sensitive substance to mark * tumor cells, then use strong light or laser light Irradiation, glare or laser light photochemically interacts with light-sensitive substances (photosensitive substances) in tumor cells or tumor tissues, causing cytotoxicity at the location where the light is sensitive, killing tumor cells (such as cancer cells). To diagnose and treat human tumors, there must be three factors: (1) containing a certain concentration of photosensitizer in the tumor tissue; (2) oxygen containing molecular complaints in the tumor tissue, and (3) light of appropriate wavelength. Clinically selected The photosensitizer must have the following conditions: 1 is basically non-toxic to the human body; 2 can be selectively stored in the tumor tissue after being injected into the human body, and is excreted from the normal tissue in a short period of time; 3 can be lighted by a certain wavelength Start-up. The selected excitation source should be compatible with the photosensitizer, ie its wavelength can activate the photosensitizer, and this wavelength of light should penetrate a certain depth of human tissue. According to experimental research, the large polymer in the photosensitizer is the main component of PDT #therapy cancer. It is believed that when the photosensitizer is injected into the human body, the photosensitizer can enter the normal tissue and the tumor tissue through the microvascular system at the beginning, but due to the tumor group The lymphatic reflux system is not as robust as the normal tissue, so these large polymers stay in the tumor for longer than normal tissue. The photosensitizer has a very strong, 1267392 and can even be used in serum and large polymers. The tendency to self-binding (molecular weights up to 6000 ' and albumin are similar in size). These polymers may stay in the liquid of the tumor stroma together with other serum components for a long time and bind tightly to the surface of the tumor tissue, then Gradually separated and combined with tumor cell components mainly with tumor cell membranes. After a certain period of time, the photosensitizer around the tumor is basically excreted, but a considerable concentration of photosensitizer is still stored in the tumor. M-rays emit fluorescence or destroy tumors. And as a necessary condition for selective treatment, they After being cleared, the Qing can not continue to be stored in the tumor. In the conventional photodynamic therapy, a planar diode matrix is listed in the skin surface treatment device, such as US Pat. No. 5,664,461, which is referred to in the first figure. The photodynamic therapy device 1a has an illuminant fixing frame 10a, and a plurality of illuminants 12a (which may be illuminating diodes) are arranged in a matrix, and each illuminant 12a has a reflector 14a for ♦ Light, although the conventional technique has a light-uniformly distributed matrix structure to match the reflector 14a of each of the illuminants 12a, the structure of the reflector i4a is too complicated to make the photodynamic therapy device la inconvenient to assemble and costly.咼 'Because the construction of the precision illuminator fixing frame l〇a must consider the cost of the manufacturing process or related fixtures, and the use of the reflector actually has an over design condition, because the actual skin is treated When it is not necessary to concentrate each point source, because the extra shot means an increase in manufacturing cost, so the above-mentioned conventional techniques have extreme The improvement space, such as simplifying the reflector 14a and simplifying the illuminator fixing frame 1a, preferably using the most common LED package of the electronics industry, and fixing the illuminating with a simple fixed frame The diode, as a result of mass production, can make photodynamic therapy no longer a privilege for a small number of patients, but can be widely used in skin tumor-related diseases by forming a popular price of 1267942. In a conventional light-emitting diode radiation device, a planar two-body matrix is listed in the plane energy radiation, as shown in US Pat. No. 5,278,432. Although it is not specifically designed for photodynamic therapy, it has certain reference value. Please refer to the LED emitter lb shown in FIG. 2, which has a polar body fixed frame i〇b, and a plurality of light emitting diodes 12b are arranged in a matrix, and each of the light emitting diodes 12b The circuit 14b is used to control the light emission. The conventional technology has a light-uniformly distributed matrix structure and a circuit i4b connected to the light-emitting diode 12b, and the diode-fixed base 10b can have a printed circuit board. Combined with related electronic components, the LED emitter lb is easy to assemble compared to the device of the first figure (the LED 12b is directly placed on the diode holder with the printed circuit board) The advantage of the above, but the low brightness of the light illumination at the edge of the 1 〇b of the diode fixed frame is a disadvantage, so that the above-mentioned technique also has a great improvement in space. Therefore, the axis of the art has a suitable application. Type # also needs to be modified when used in photodynamic therapy, but its easy-to-assemble characteristics can be used in photodynamic therapy illumination devices, enabling ί to be used in new applications (photodynamic therapy specifically for skin irradiation) Most of the photosynthesis of the skin; the light of the sentence, the need for large areas and irradiation led to the inventors' efforts to develop::: cost manufacturing and ease of use [invention content] χ本务月 to achieve the above The main purpose of the present invention is to make it possible to maintain a uniform structure, to have a simple structure of the first dynamic therapy light source device, and its 1267392 professional structural structure needs to conform to the facial curve for easy illumination, and can be applied to the skin. The tumor can provide high-quality medical effect characteristics, and the control circuit can adjust the current or voltage to adjust the brightness of the light source device, which is convenient for different needs photodynamic treatment. To achieve the above object, the present invention provides a Fixing the pedestal with the illuminant (which may include a printed circuit board and the printed circuit board has a flat surface capable of bonding the LED) Red matrix diodes and blue LEDs arranged in a matrix, plus the edge of the matrix is reflected by the reflector (adjusting the light uniformity) or the light-emitting diodes are spaced apart by a narrow spacing on the outer side of the matrix. The method for adjusting the uniformity of light is developed as a main structure in combination with a conventional electronic device process and peripheral devices. The structure of the present invention comprises: an illuminant fixed pedestal; a plurality of red illuminants distributed in a matrix The method is disposed on the illuminant fixed base; and the plurality of illuminating illuminants are disposed on the illuminant fixing base in another matrix distribution manner; when the red illuminant or the illuminating body is arranged When the number of distributions in a specific range is formed at a certain interval, the illuminator fixed base has a light reflecting surface; when the red illuminant or the illuminating illuminator is arranged in an inner portion, When the wide distance is predetermined and the edge side is at a predetermined narrow distance, the illuminator fixing base edge does not have a light reflecting surface. The detailed description of the present invention and the accompanying drawings are to be understood by the appended claims . [Embodiment] The present invention is divided into a portable (p〇rtable) and a professional (Professional) design, and the factors that affect the energy distribution of the illuminance are: 1267392 The distance between the LED and the illuminated surface, the radiation distribution of the LED, and the optical power of the LED. The size (operating current and temperature), the arrangement of the LEDs, the design of the edge-increasing reflective surface, and the use of diffuser, etc., all affect the light intensity distribution of the illuminated surface. The invention adopts a red-blue light-emitting diode (LED) and is designed in a matrix distribution manner. The principle is based on the medical application published by the British Journal of Dermatology 2000: 142: 973-978 for red and blue light: blue light (415 nm) It can be used in combination with red light (660nm) to treat mild to moderately severe acne (acne vulgaris) for three months. The blue LED spectrum includes 9% in the ultraviolet range, with anti-bacterial action and does not kill the skin. Irradiation: 4. 23 mW/cm2, 15 minutes per day, cumulative 320 J/cm2. The red light has an anti-inflammatory action, and the irradiation amount is 2 67 mW/cm 2 , 15 minutes per day, and the total is 202 J/cm 2 . The optical power distribution per square centimeter is between 2.67 mW/cm2 and 4·23 mW/cm2. The dose of each treatment in photodynamic therapy is based on the accumulated energy, so the optical power distribution The stronger the intensity, the shorter the exposure time. The development of the present invention is directed to a device for designing a photodynamic therapy with dual wavelength illumination having dual wavelength red and blue light. The following is a complete simulation and design for the system prototypes with different requirements and arrays discharged according to different specifications of L E D . In addition to the design of locally used photodynamic therapy equipment, professionally designed full-cover equipment is also available to adapt to different requirements to meet system requirements. Please refer to the following terms and units: Radiant Flux: 1267392 ~ Lumens ~ Joules / sec / sec) Radiant intensity
Ie^)=^(W/Sr) dll Ιυ(λ) =智(Lm/Sr) αΩ 照射度（Irradiance E(W/cm2))Ie^)=^(W/Sr) dll Ιυ(λ) = wisdom (Lm/Sr) αΩ Irradiance (Irradiance E(W/cm2))
Ee(X)(W/cm2) = ^^(W/cm2)Ee(X)(W/cm2) = ^^(W/cm2)
OjtLOjtL
Ev(X)(Lm/m^) = (Lm/m^) 輝光效率（Luminous efficiency) A "、〜輝光流量Θ (pv{Lm) Ό %⑺〜輻射流量(不） 請再參考以下之計算式（請參考第三圖所示）： άω dA ___ InRsinO -Rd9 ~¥~ Έ2 =2π sin0 άθ (弧度變量）Ev(X)(Lm/m^) = (Lm/m^) Luminous efficiency A ", glow flow Θ (pv{Lm) Ό %(7)~radiation flow (no) Please refer to the following Calculation formula (please refer to the third figure): άω dA ___ InRsinO -Rd9 ~¥~ Έ2 =2π sin0 άθ (radian variable)
···九=/0 J2;rsin0 .洲=V /,, (0) · 2π：sin0 · Α0 ο (一定弧度輻射強度） or — = Ir(9)-2nsme ·ΑΘ Ι〇 (單位弧度輻射強度） 1267392 由上述之推演公式再參考第四圖之發光二 一 =:圖及第五圖之電流對亮度分佈二由 LITE-ΟΝ料號LTST-C19〇KRKT之規格書摘錄下）可知=弧 ==度’即可用電腦模擬陣列狀排列之發光二極體的發 ㈣二：m 圖到第六c圖所示之表面黏著 型的發先二極體形式，即具有石夕基樹脂1G魏及陰極標示 12之長方形㈣二極體，其可以其底面之陰極接點及 陽極接點16黏著在印刷電路板上。 請參考第七圖所示之紅光二極體陣列20及获光二極 體陣列30配合圓形發光體固定基座50邊緣具有^環^反 射面40之設計（攜帶型），其中紅光632nm採用lite_⑽ LTST-C190KRKT-R(BIN Code)，操作電流 If =2〇roA 時，規 格如上所述。至於405nm藍光則採用其他相同包妒 (0603size)的LED(亦可使用不同尺寸包裝但須排列間隔 均勻）。經過電腦模擬得出632nm波長LED的陣列分佈（第 七圖）及光分佈（第八B圖X方向分佈及第八(^圖γ方向分 佈配合第八Α圖整面分佈狀況）由此可看光均勻地分部於 照射面上。 ' 再請參考第九圖所示專業型之七個子平面6〇形成一 U 形圓弧之大型光源裝置，其中每一子平面60具有紅光二極 體陣列20及藍光二極體陣列30，且具有一特定之排列方 式70，即排列規則為内側部排列以預定寬距離而邊緣侧以 預定窄距離（如第十圖所示），且其巾該專業型為—圓弧狀 設計共分七片長條型，如第九圖，每一片專業單片長條型 LED分佈如第十圖所示。由於未能在邊緣使用反射鏡面， 11 1267392 但可藉著調整中間的LED間距使邊緣的光分佈更均勻，LED 分佈如第十圖，光分佈如第十一圖，可做到在20cm長度内 的光分佈均勻，對大部份人的臉部長度是足夠的。 在此對本發明構造做一敘述；一發光體固定基座50 ; 複數個紅光發光體（即紅光二極體陣列2〇)，以一矩陣分佈 方式設於該發光體固定基座50上；及複數個藍光發光體 (藍光二極體陣列30)，以另一矩陣分佈方式設於該發光體 固定基座50上；當該紅光發光體或該藍光發光體之排列規 則為以一定間隔形成一單位面積具一特定範圍内之分佈數 量時（即均勻式分佈），該發光體固定基座50邊緣具光反射 面40 ;當該紅光發光體或該藍光發光體之排列規則為内侧 部排列以預定寬距離而邊緣侧以預定窄距離時（即前述之 專業型之分佈方式），該發光體固定基座50邊緣不具光反 射面40。 以下將詳述本發明之實施例細部變化；其中該矩陣分 佈方式可為每一橫向紅光發光體等距且每一縱向紅光發光 體等距；且其中該另一矩陣分佈方式可為每一橫向藍光發 光體等距且每一縱向藍光發光體等距；其中該複數個紅光 發光體與該複數個藍光發光體係可分佈於同一發光體固定 基座之一平面或數個平面上；其中該固定基座可形成一 U 形曲面或數個平面形成U形，以罩住使用者之面部進行治 療；進一步可包含一框架，以固定該發光體固定基座；其 中該發光體固定基座可具有一把手；進一步可包含一腳 架’以支撐该發光體固定基座於一平台上；進一步可包含 一外殼，為導熱材料所製成；進一步可包含一散熱片與一 散熱風扇，其中該散熱風扇吹送氣流用於具對該散熱片進 12 1267392 行散熱；進一步可包含一電流控製電路設於該發光體固定 基座，以對該紅光發光體或該藍光發光體進行亮度控制； 進/步可包含一光擴散罩設於該紅光發光體及該藍光發光 體之對面，以擴大H?、射區域，進一步可包含一光集中罩設 於該紅光發光體及遠監光發光體之對面，以局部強化照射 區域；其中該發光體固定基座為可摺疊之構造；進一步可 包含一電池裝置，設於該發光體固定基座；其中該紅光發 光體或該藍光發光體可為發光二極體或有機發 構成；其中該紅光發光體可為632-660簡波^及^藍光發 光體為405-415nm波長等之範圍内。 風 义 須知本發日狀表轉著技術之發光二極之生產機械設 備亚非尚價或不易取得之設備，且反射面40亦為一般手電 筒常用之聚光裝置，因此本發明之設置容易；且本發明之 基材構造兼鋪造容易及發光均句；又本發明對傳統電子 裝置之加工程序影響不大，完全可以溶入舊有電子裝置生 產程序#巾’舊有電子裝置機台不需大幅紐，為符合製 造實際狀況而有用的發明。 本电明有以下優點：⑴生產容易，所需新添設備價格 及技術要求皆不大⑵光均勻度度佳⑶容易大量生產⑷ 針對皮膚疾病之特別設計。 紅、ϊΐ所述’本發明實為—不可多得之發明發明產品， =2_性、新穎性及進步性’完全符合發明專利 利1以#2依專利法提出申請’敬請詳查並賜準本案專 牙J以保卩羊發明者之權益。 【圖式簡單說明】 第一圖·為習知光動力治療之裝置示意圖； 13 1267392 第二圖：為習知發光二極體陣列光源示意圖； 第三圖··為發光二極體輪射角度計算參考示意圖； 第四圖：為發光二極體輻射角度對強度示意圖； 第五圖：為發光二極體輻射強度對電流強度示意圖； 第六A圖：為發光二極體上視示意圖； 第六B圖：為發光二極體底視示意圖； 第六C圖：為發光二極體侧視示意圖； 第七圖：為本發明第一實施例示意圖； 第八A圖：為本發明第一實施例平面輻射強度示意圖； 第八B圖：為本發明第一實施例X軸輻射強度示意圖； 第八C圖：為本發明第一實施例Y軸輻射強度示意圖； 第九圖：為本發明第二實施例示意圖； 第十圖：為本發明第二實施例子平面示意圖；及 第十一圖：為本發明第二實施例子平面X軸輻射強度示意 圖。 【主要元件符號說明】 光動力療法裝置 1 a 固定機架 10a 發光體 1 2 a 反光罩 14a 發光二極體放射裝置 1 b 二極體固定機座1 0 b 發光二極體 1 2 b 電路 14b 矽基樹脂 1 0 陰極標示 1 2 陰極接點 1 4 陽極接點 1 6 紅光二極體陣列 2 0 藍光二極體陣列3 0 反射面 4 0 發光體固定基座5 0 14 1267392 子平面···九=/0 J2;rsin0.洲=V /,, (0) · 2π:sin0 · Α0 ο (a certain radian radiance) or — = Ir(9)-2nsme ·ΑΘ Ι〇 (radians in radians Intensity) 1267392 From the above formula and then refer to the fourth figure of the light-emitting two = one: the current and the brightness distribution of the figure and the fifth figure are extracted from the specification of the LITE-ΟΝ material number LTST-C19〇KRKT) == degree' can be used to simulate the array of light-emitting diodes in the array (4) 2: m to the surface of the surface of the sixth-figure type of the first two-pole form, that is, with Shi Xiji resin 1G Wei And a rectangular (four) diode of the cathode designation 12, which can be adhered to the printed circuit board by the cathode contact of the bottom surface and the anode contact 16. Please refer to the design of the red light diode array 20 and the light-receiving diode array 30 shown in FIG. 7 with the circular light-emitting body fixing base 50 having a ring-shaped reflecting surface 40 (portable type), wherein red light 632 nm With lite_(10) LTST-C190KRKT-R (BIN Code), the operating current If = 2〇roA, the specifications are as described above. As for 405nm blue light, other LEDs of the same package (0603size) are used (can also be packaged in different sizes but evenly spaced). After computer simulation, the array distribution of the 632nm wavelength LED (seventh image) and the light distribution (the eighth B-shaped X-direction distribution and the eighth (^ γ-direction distribution and the eighth-order map distribution) can be seen. The light is evenly distributed on the illuminated surface. 'Please refer to the seven sub-planes 6 of the professional type shown in Figure 9 to form a U-shaped arc large-scale light source device, wherein each sub-plane 60 has a red LED. The array 20 and the blue LED array 30 have a specific arrangement 70, that is, the arrangement rule is that the inner portion is arranged at a predetermined wide distance and the edge side is at a predetermined narrow distance (as shown in the tenth figure), and The professional type—the arc-shaped design is divided into seven strips. As shown in the ninth figure, each professional single-piece strip LED is distributed as shown in the tenth figure. Since the mirror surface cannot be used at the edge, 11 1267392 By adjusting the middle LED spacing to make the light distribution of the edge more uniform, the LED distribution is as shown in the tenth figure, and the light distribution is as shown in the eleventh figure, so that the light distribution within the length of 20 cm can be evenly distributed to the face of most people. The length is sufficient. Here, the construction of the present invention is made one. a illuminant fixed pedestal 50; a plurality of red illuminants (ie, a red LED array 2 〇) disposed on the illuminant fixing base 50 in a matrix distribution manner; and a plurality of blue illuminants (Blu-ray diode array 30) is disposed on the illuminant fixing base 50 in another matrix distribution manner; when the red illuminant or the blue illuminant is arranged in a regular interval, a unit area is formed at a certain interval. When the number of distributions in a specific range (ie, uniform distribution), the edge of the illuminant fixing base 50 has a light reflecting surface 40; when the arrangement of the red illuminating body or the blue illuminating body is arranged at an inner side portion at a predetermined wide distance When the edge side is at a predetermined narrow distance (that is, the distribution pattern of the aforementioned professional type), the edge of the illuminant fixing base 50 does not have the light reflecting surface 40. Details of the embodiment of the present invention will be described in detail below; Each of the lateral red illuminants may be equidistant and each longitudinal red illuminator is equidistant; and wherein the other matrix distribution may be equidistant for each lateral blue illuminant and equidistant for each longitudinal blue illuminator The plurality of red light emitters and the plurality of blue light emitting systems may be distributed on one plane or a plurality of planes of the same light fixture fixing base; wherein the fixed base may form a U-shaped curved surface or a plurality of planes to form U Forming to cover the face of the user for treatment; further comprising a frame for fixing the illuminator fixing base; wherein the illuminant fixing base may have a handle; further comprising a tripod 'to support the illuminant The fixed base is mounted on a platform; further comprising a casing made of a heat conductive material; further comprising a heat sink and a heat dissipating fan, wherein the cooling fan blows the airflow for dissipating heat to the heat sink 12 1267392 Further, a current control circuit may be disposed on the illuminant fixed base to perform brightness control on the red illuminant or the blue illuminant; the step/step may include a light diffusion cover disposed on the red illuminant and The opposite side of the blue light emitting body is configured to expand the H?, the emitting region, and further includes a light collecting cover disposed opposite the red light emitting body and the remote monitoring light emitting body, The illuminant fixing base is a foldable structure; further comprising a battery device disposed on the illuminant fixing base; wherein the red illuminator or the blue illuminator can be a light emitting diode The body or organic hair composition; wherein the red light emitter may be in the range of 632-660 simple wave and the blue light emitting body is in the range of 405-415 nm wavelength or the like. The meaning of the wind is that the production of the mechanical device of the light-emitting diode of the technology is not expensive or difficult to obtain, and the reflecting surface 40 is also a concentrating device commonly used for general flashlights, so the setting of the present invention is easy; Moreover, the substrate structure of the present invention is easy to fabricate and illuminate; and the invention has little effect on the processing procedure of the conventional electronic device, and can be completely dissolved into the old electronic device production program #巾' old electronic device machine does not A large-scale new invention is required to meet the actual conditions of manufacture. This product has the following advantages: (1) easy production, low price and technical requirements for new equipment (2) good light uniformity (3) easy mass production (4) special design for skin diseases. Red, ϊΐ ϊΐ 'The present invention is actually - rare inventions of invention products, = 2 _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ The special case of this case is given to protect the rights of the inventor of the sheep. [Simple description of the diagram] The first picture is a schematic diagram of the device for the conventional photodynamic therapy; 13 1267392 The second picture is a schematic diagram of the light source of the conventional LED array; The third picture is the reference for the calculation of the emission angle of the LED Schematic diagram; fourth diagram: a schematic diagram of the radiation angle versus intensity of the light-emitting diode; fifth diagram: a schematic diagram of the radiation intensity versus current intensity of the light-emitting diode; Figure 6A: a schematic diagram of the upper side of the light-emitting diode; Figure: is a bottom view of the light-emitting diode; Figure 6 is a schematic side view of the light-emitting diode; Figure 7 is a schematic view of the first embodiment of the present invention; Figure 8A is a first embodiment of the present invention Schematic diagram of plane radiation intensity; FIG. 8B is a schematic diagram of X-axis radiation intensity of the first embodiment of the present invention; FIG. 8C is a schematic diagram of Y-axis radiation intensity of the first embodiment of the present invention; BRIEF DESCRIPTION OF THE DRAWINGS FIG. 10 is a plan view showing a second embodiment of the present invention; and FIG. 11 is a schematic view showing a plane X-axis radiation intensity according to a second embodiment of the present invention. [Main component symbol description] Photodynamic therapy device 1 a Fixing frame 10a Illuminant 1 2 a Reflector 14a Light emitting diode radiating device 1 b Diode fixed stand 1 0 b Light emitting diode 1 2 b Circuit 14b Mercapto Resin 1 0 Cathode Indication 1 2 Cathode Contact 1 4 Anode Contact 1 6 Red Light Diode Array 2 0 Blue Light Diode Array 3 0 Reflecting Surface 4 0 Luminaire Fixed Base 5 0 14 1267392 Sub Plane