TWI229246B - Brain cooling and regulation system for infants with perinatal asphyxia - Google Patents

Abstract

A brain cooling and regulation system for infants with perinatal asphyxia is considered and invented. The proposed system consists of eight subsidiary parts as modules, namely, a control module, a display module, a temperature-measuring module, an analog/digital converter module, a digital/analog converter module, a driver module, a DC water-pump module, and a head cooling helmet module. Functions of these modules are explained as follows: The control module plays an important role as a data-processor and as the main-controller of the overall system. The display module is connected to the control module and displays both set-point and current measured temperature. Two temperature-measuring modules are utilized to measure the infant's anal temperature and temperature inside the cooling cap respectively. Corresponding outputs are two analog signals in direct proportion to the measured temperatures. Two analog/digital (A/D) converter modules are used to convert the analog signal outputs by the temperature measuring modules into digital signals, and to bridge them into the control module for further processing and manipulating. A digital/analog (D/A) converter module is employed to convert the digital regulation command signal that is generated by the control module into an analog signal as an output control command. A driver module is used to receive the control command by the D/A converter module and generate a closed-loop feedback, variable power supply to drive an DC pump; and a DC water-pump system is used to regulate the infant's head core temperature via the iced-water flow through the head cooling helmet, the iced-water flow rate is linearly regulated by the variable power supply of the driver module. However, the infant's head core temperature cannot be directly measured, while among all of the measurable temperatures, the anal temperature is the closest to the head core temperature. Previously, temperature inside the infant's head cooling device is regulated, while the anal temperature is measured manually. The set-point of the cooling cap temperature is manually changed accordingly. The essential technology characterizes the presented invention is that the anal temperature is measured automatically by an electronics device and the same measured temperature is utilized as the feedback signal to regulate the head cooling system in the closed-loop fashion. Thus, human factors can be drastically avoided to reduce improper treatments.

Description

1229246 V. Description of the invention (1) [Technical Field] The present invention relates to the design of head cooling regulation therapy, especially for neonatal hypoxic asphyxia (Asphy X ia), which is damaged due to cerebral ischemia and hypoxia. (Ischemic-Hypoxic Encephalopathy, IHE), which causes neurological diseases of the brain. The use of hypothermia (hypothermia) allows the brain's nervous system to repair itself. The method used is called the head cooling regulation method. [Previously Press Change, Reason. Oxygen and stage treatment, Fang Qizi, then temperature steps, risk over technology] 'The production process has been a freshman research found that the damage, 6 to the onset and 1 to the production process method is divided into two one for the whole body to use Within the projection range, but there are various ways to cause the death of newborns in various brains in hypoxic 15 to 4 years of age. The method of lack of brain: the lack of heater due to the general condition of the child here, or the asphyxia of the back brain. After the onset of time, there will be oxygen suffocation in the nervous system of the second brain. The newborn is often covered, and the new germline is controlled to maintain the risk of neonatal insufficiency. It is important for blood hypoxia injury to continue through the systemic pathology. The onset of blood and deficiency stages, and the disease is closely related. The special blanket for cold water circulation is used to treat the cold water circulation. The anus temperature of the child is cooled by a predetermined amount of body temperature.

The second is the head cooling control of the head. "Γ" · The head cooling system is used to keep the interior of the newborn to a lower temperature setting than the previous two systems. This method can make the head cooler. The complex effect is better, that is, a lower temperature makes the protection better, which will not cause systemic loss of temperature, but the head cools down in the past

1229246 V. Description of the invention (2) method, often in simple weeks; foreign research temperature control method 'in order to monitor this requires frequent intracranial temperature, but the temperature setting in the operator is inconvenient, so, today, sincere να% The early method is better than the neonatal control to maintain the goal of life-long change. It must be long, must be long, reach the opposite, and think _ "One pole execution, advanced, the head of the neonatal circulation in the helmet is stable due to the accumulation of anal phase. Waiting for efforts, such as using a lot of ice to use the temperature of cold water, but the anal temperature is the most prevalent in the setting of the thermostat temperature of the pre-helmet, only the anal temperature can be artificially negligent. The head must always be measured with a temperature range to achieve a reasonable intracranial ability near the head, so the risk is high. Seek ideal and realistic goals. 0 Four heads of the child to measure the temperature around the anus, because the head is stable The temperature of the ministry is adjusted; the operation and use of the helmet can be adjusted and improved. [Invented the general instrument of the hypoxia and hypoxia method. After measuring and setting the temperature in the control, enter the system. The content of the invention is the invention of the first main blood * asphyxiation of the head and the collapse of the head. It is also new and does not count the full set from the module. The head-cranial anus temperature is replaced by the anal temperature and the signal is adjusted to directly adjust the intervention. It is to provide a cooling regulation treatment design. At that time, the instrument designed for coordination is equipped with an automatic feedback control regulation. Its anal temperature cannot be measured because of the temperature in the anal temperature. Therefore, the actual anal temperature is compared with the instrument. Take out the error, and treat the possibility of improper treatment through the purpose of intracranial temperature on the head of Doosi Temple, which is circulated by ice water (or cold water). A new type of cooling adjustment device; After the formation of the helmet, the method of treating newborns is greatly reduced. After the head and skull are directly measurable, the calculation of the coagulation system is completed because the person is 1229246. V. Description of the invention (3) The first main object of the present invention is to provide a Neonatal hypoxia and asphyxia head cooling regulation treatment design, the cooling regulation system is closed loop automatic control system, and the helmet Temperature and anal temperature ^ The process and records of the two-vision, recording and control adjustment are completed by the computer. ^ The second record is complete and detailed, which is helpful for future research and analysis. Π The third main purpose of the present invention is to provide A kind of neonatal hypoxia and asphyxia apnea head cooling regulation treatment design. The cooling regulation system is a closed loop automatic control system. The control method is linear, continuous, and can be used; two control errors are small. The main purpose is to provide a neonatal hypoxic-ischemic head cooling regulation treatment design. The cooling regulation system is also added with the & = analogue standby control module. When the main digital control module is cpu ^ ^, ^ Power supply system: when it is normal, it can automatically switch to the analog line ': control is still closed-loop control' to achieve the purpose of tuning; therefore, the present invention can be regarded as a dual control material with backup: to improve the reliability of the system Sex. ] The diameter system is the system. The reason is that the present invention provides a kind of Jin production temperature adjustment therapy design, including: 'children with rolling ischemic asphyxia head reduction control module, what is it?' Display and operation module, ^, ,, and calculation and control of each core group; The previous measured temperature value and preset ^ are connected to the control module, which can display the eye-temperature measurement module, Department: 5 f 'degree value and output analog signal' · ”The temperature analog / digital conversion module of the internal and anal temperature of the child's helmet is the output of the temperature measurement module.

苐 Page 14 1229246 V. Description of the invention (4) An analog signal is converted into a digital signal, and the < — digital / analog conversion module is used to calculate ^; the bit signal is converted into an analog signal? Tiger, and the output _group ^ =, and a driver module, is to receive the digital / analog conversion " ^ ^ Λ 杌, after the signal processing operation, the output has the control of ^ = ^ 7 · output DC output. The variable adjustment degree is closest to the head cranial ΐ: ί group J :: the door temperature, which is changed to the measurable because of the temperature of the anus: the intracranial temperature cannot be measured. 'Dish and replace it; the actual anal temperature is calculated by the instrument control module': the second anal sigma door temperature is compared, and the error is brought out, and the head is directly adjusted by intracranial, w:: withering condensation system The amount of traffic that was achieved caused the treatment to be ineffective: ::, which is greatly reduced due to human factors. [Embodiment] Regarding the effects of the present invention a and other, hereby ^ ^ The above-mentioned purposes, the technology, means and methods used are as follows . + A detailed description of the preferred feasible embodiment and the drawings. First of all, please cooperate with Quan Yi__ A kind of newborn missing & steps 1 and 2 show, a control module (1, 1) The method for adjusting the head temperature from air ischemia to rest is mainly a temperature measurement module (2), a display and operation module (2 0), a 0), an analog / digital conversion module (4 0), 1229246 5. Description of the invention (5) The drive module (60), a digital / analog conversion module (5), and a condensation system (70). Among them, the control module 1 and (work 0) are used to control the system. And the calculation and control of each module, its function can be used as a system by the microprocessor: digital / analog output and analog / digital wheel 2: linear control for group control, data transmission control " 'manipulation, display and operation The connection is-LCD display (2); control = group 9 ("), where the LCD display (2 丄 key cover (2 2) is crying, the first shot &-丄) is one or two rows of 20 The word LED Xiangwu mouth brother shows that the current measured temperature value, the first and the second-box _ ", and the degree value; and the display The operation module (? Η 1 f is unpredictable and the temperature (9? W ^ The operation of the Yong Zuo branch group (2 0) is to change the operating mode, set parameters, etc. using the keyboard [2 2). The temperature measurement module Group (30), Department

AD5 90 (3 1) 谌 # Gan eight. , 朵 ^ U (c, 0, 〇), 刀, through the corresponding temperature sensor ^ 3 3) to measure the value of the head and anus of the newborn (8 0), and turn out Analog signal; where the temperature sensor (32) is directly inserted into the baby's anus; the head temperature or anus temperature obtained by the temperature measurement module (30) is measured by the temperature sensor 590 (3).丄) After obtaining it, the signal of its degree is adjusted by the circuit calculation, and the steamer is at the voltage of 0 · iv〇lt / C = the output of the module, if the temperature is 37.2. 〇, the module output is 3 Volt. The analog / digital conversion module (4 〇) uses two ADC8804 (4 1) 8-bit analog / digital converters with the same resolution of 〇 · 〇196 VO 1 t / bi 1: The temperature measurement module (30) measured the newborn on page 16. 1229246 5. Description of the invention (6) ---- The temperature analog signal is converted into the corresponding digital signal and output to the control branch (丄 0). Save. The digital clock-to-ratio conversion module (50) uses two 8-bits

Voltb; ^ 1DAC〇8〇8 (51) ^^^^ 0.0196 Control signal ^ thorn drag Ϊ The corresponding digital motion module (\ 〇) output by the control module (10) 'Analog control signal' is enlarged and adjusted 2 f (6 °) for adjusting the drive input and then the digital / analog conversion module (50)

Method; The driving mode is a pressure source that controls the flow of the condensing system. (Voltage contl * Ql VQltage has a DC-powered electric power source with DC pump, circuit 6 and J Ertian fóurce, vcvs), and the driver 2SC1384. ^ Cheng Zhi uses a linear amplifier LF356 to control the output to the DC channel in a closed loop mode: a wide amplifier circuit to achieve the output flow of the pump to drive the condensation system (/ check; _ adjust the DC channel water with ^) to circulate in a special system Head cover. 'Circulated ice water (or cold basin traditional (70)) uses a cotton soft cap (7U, 〇) with different head shapes; nm and can adapt to newborns "Tin;; = wearing; in the cap body (7 3), as heat insulation and to improve the cold part 2 (7 2) and-foam layer (7 and stacked with condensation tube (74) inside the condensation layer (") Silicone tube) is a three-dimensional rotating coil. It takes s (7 4) (the time to keep the purity in the south, and the condensing tube (7 4), plus the contact area and the increasing contact with moving condenser (ice water or cold water).

1229246 V. Description of the invention (7)), and the temperature sensor (33) above the condensing tube (γ 4) to measure new: == (30 temperature value. The angle of the condensing tube (7 4)香 ^ 〇) The heat transfer medium between the head heat of the head and the condensing agent: m :, as = the feeling of skin frostbite or skin discomfort on the surface, and the condensing agent in the condensing tube) is driven by a variable speed DC pump , The cold;) is driven by the drive module (60) V / spin, and charge (705 (β η) Han Qiu ^, Zhoujie control signal to the new brother I 8 0) head The unit performs temperature adjustment. In this way, the temperature of the anus is closest to the head and measured directly in the control module, so the closest to the measurable temperature is automatically measured by the instrument (3 Q comparison, find the error, and adjust the condensation system by the control module ( The purpose of fluidity is to greatly reduce the possibility of human beings. In addition, the methods of the present invention are linear and continuous, and the monitoring records of internal temperature and anal temperature can be completed by computer, and the experimental data is researched and analyzed. (10 Temperature of the anus), (10 amount, which is due to the reduction of the closed-loop effect, the record is finished) set the anus 'the head and the internal temperature of the anus instead of the set anus) after the operation is completed into a direct adjustment intervention' The errors caused by automatic control and control are neat and detailed. There is a door temperature, so the temperature cannot be used. The actual anal door temperature is compared with the output signal. The system is controlled by the treatment of improper intracranial temperature of the head. It is worth mentioning that the present invention also adds a spare control module, which is a combination of hardware such as a car parent, a proportional amplifier, an integrator, and an adder.

Page 18 1229246 V. Description of the invention (8) Analog linear controller, when the CPU of the control module is down or faulty, and the power system is still normal, it can automatically switch to the analog linear controller, the temperature set point is delayed The settings sent by the previous digital / analog output module are used to drive and adjust the output flow of the DC pump after being calculated by the analog linear controller. The closed-loop control can also be completed to achieve the purpose of adjusting the intracranial temperature of the head. It is a dual-controller system with backup to improve the reliability of the system. Λ-Λ- In summary, the design of the hypothermia and ischemia asphyxia of the head of the newborn in accordance with the present invention can effectively solve the problems of the methods of adjusting the head in the past, so the practicability and progress of the present invention are indispensable. Doubt it, and check the relevant documents and materials, and found no similar creations were published first. Therefore, the "newness" and "progressiveness" of the present invention have been met, and an application for an invention patent has been filed according to law. I would like to ask for your review and grant a quasi-patent as early as possible.

Page 19 1229246 The diagram briefly explains the diagram part: the first diagram is the flowchart of the present invention and the second diagram is the block diagram of the present invention. (1) Control module (20) display and operation mode Group (22) Keyboard (3 0) Temperature measurement module (3 2) Temperature sensor (2 1) Display (31) Temperature sensor AD590 (3 3) Temperature sensor% (40) Analog / digital conversion mode Group (41) converter ADC08 04 (50) digital / analog conversion module (51) converter DAC0 8 0 8 (6 0) drive module (7 1) cap body (7 3) foam layer (7 0) Condensation system (72) Tin foil layer (74) Condensation tube (80) Newborn

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Claims (1)

1229246 VI. Scope of patent application 1 · A neonatal hypoxic-ischemic asphyxia head cooling regulation treatment design, including: "Control module" is the system and the calculation and control of each module; ^ a display and operation module It is connected with the control module to display the standard s-measured temperature value and the preset temperature value; / Dish degree measurement module is used to measure the temperature value of the interior and anus of the newborn helmet, and output the analog Signal; ^ / digital conversion module, which converts the analog = signal output by the temperature measurement module into a digital signal, and outputs it to the control module for calculation; > σ digital / analog conversion module, which controls the control The digital lambda number obtained by the module operation is replaced with an analog signal and a set of analog control signals is output; the driver module receives the control k__ output from the digital / analog conversion module and outputs Variable power supply for feedback control; Ji, ☆ = rupture system, which is the variable power supply output by the drive module, adjusts the flow, and circulates ice water (or cold water) to the specially-made helmet. Head-guney Adjust the temperature; the most used is to set the anal temperature on the control module. 'Because the anal temperature is changed to the internal temperature, the temperature inside the head cannot be measured, so it can be replaced by the "anal temperature; the actual anal temperature is determined by After measuring, compare the temperature with the set anus temperature to find the error. After the Du ^ calculations are performed, the output signal adjusts the flow of the condensation system. = ， The purpose of adjusting the intracranial temperature of the head, greatly reducing , Causing the possibility of improper treatment. " 1 Page 211229246 6. Scope of patent application ___: The hypoxic-ischemic asphyxia head of the newborn, the center of systematic operation and control, the function can be = micro-processing, digital / seat from "丨 *, and · Linear suppression if used as module and system, output and analog / digital input module control, display ^ #,, guard, data transmission control, backup control module control. '、 Still 3 · As described in item 1 of the scope of the patent application, the hypoxia of the newborn can be adjusted to reduce the temperature. 士 # 姑 _ t The right side of the first word of ischemia and asphyxia is treated again. And the operation module is a two-line 2D-bedding state. The first measured temperature value is displayed invisibly, and the first one is displayed with a preset temperature value. Brother Yi 仃 The hypoxic-ischemic asphyxia of the newborn as described in item 1 of the scope of patent application 邛 Cooling adjustment treatment design, in which the operation of the display and operation module ^ Use the keyboard to change the operation mode and set parameters. 5. The design of hypothermia and ischemia-asphyxia head cooling regulation treatment for newborns as described in item 1 of the scope of patent application, wherein the temperature measurement module is an Ic-type degree-sensing AD590. Huyou 6 · The design of head hypothermia adjustment treatment for neonatal hypoxic-ischemic asphyxia as described in item 1 of the scope of patent application, where the analog / digital conversion module is 8-bit analog / digital converter ADC0804, resolution 0. 0196 Volt / bit. 7 · Hypoxic-ischemic asphyxia head of newborn as described in item 1 of the scope of patent application Page 22 1229246 VI. Scope of patent application Ministry of temperature control treatment design, where the digital / analog conversion module is an 8-bit digital / analog converter DAC0 808 with a resolution of 0.0196 Volt / bit. 8. The hypothermic ischemic asphyxia head cooling regulation treatment design described in item 1 of the scope of the patent application, wherein a backup control module is also provided, which is a comparator, a proportional amplifier, an integrator, and An analog linear controller composed of hardware such as an adder to improve the reliability of the system. Page 23